ACOT9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a mitochondrial acyl-CoA thioesterase of unknown function. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neutrophil activation involved in immune response (GO:0002283)4.30367582
2regulation of cytokine secretion involved in immune response (GO:0002739)4.02289165
3negative regulation of interleukin-12 production (GO:0032695)3.94158125
4negative regulation of nitric oxide biosynthetic process (GO:0045019)3.57418084
5regulation of chronic inflammatory response (GO:0002676)3.51676526
6positive regulation of defense response to virus by host (GO:0002230)3.47708556
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.44538084
8positive regulation of NF-kappaB import into nucleus (GO:0042346)3.33957330
9natural killer cell mediated immunity (GO:0002228)3.30854365
10natural killer cell mediated cytotoxicity (GO:0042267)3.30854365
11antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.26943661
12ribosomal small subunit assembly (GO:0000028)3.24926037
13kynurenine metabolic process (GO:0070189)3.23596594
14type I interferon signaling pathway (GO:0060337)3.22438478
15cellular response to type I interferon (GO:0071357)3.22438478
16formation of translation preinitiation complex (GO:0001731)3.21647884
17antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.21465317
18regulation of vitamin D biosynthetic process (GO:0060556)3.21053886
19response to type I interferon (GO:0034340)3.18147288
20immunoglobulin mediated immune response (GO:0016064)3.15476297
21Arp2/3 complex-mediated actin nucleation (GO:0034314)3.14843923
22regulation of memory T cell differentiation (GO:0043380)3.11793400
23T-helper 1 type immune response (GO:0042088)3.04281580
24negative regulation of viral genome replication (GO:0045071)3.03945788
25positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.02856419
26B cell mediated immunity (GO:0019724)3.01586005
27regulation of mononuclear cell migration (GO:0071675)2.99655359
28negative regulation of nitric-oxide synthase activity (GO:0051001)2.98745413
29sequestering of actin monomers (GO:0042989)2.95271625
30lipopolysaccharide-mediated signaling pathway (GO:0031663)2.92284905
31positive regulation of interleukin-17 production (GO:0032740)2.90455751
32regulation of MHC class I biosynthetic process (GO:0045343)2.90360850
33ribosome assembly (GO:0042255)2.89720130
34negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.89713772
35positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.87919456
36tryptophan catabolic process (GO:0006569)2.86607664
37indole-containing compound catabolic process (GO:0042436)2.86607664
38indolalkylamine catabolic process (GO:0046218)2.86607664
39regulation of interleukin-1 beta secretion (GO:0050706)2.85887258
40positive regulation of chemokine biosynthetic process (GO:0045080)2.83992469
41response to peptidoglycan (GO:0032494)2.83290488
42positive regulation of interleukin-1 beta secretion (GO:0050718)2.83195809
43ribosomal large subunit biogenesis (GO:0042273)2.81583938
44DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.80098777
45intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.76938805
46signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.76938805
47positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.75904339
48positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.75660325
49neutrophil activation (GO:0042119)2.74982488
50antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.74542312
51signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.74471271
52signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.74471271
53signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.74471271
54maturation of SSU-rRNA (GO:0030490)2.73702001
55nucleobase-containing small molecule interconversion (GO:0015949)2.72659744
56regulation of metalloenzyme activity (GO:0048552)2.72242117
57regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.72095989
58positive regulation of interferon-alpha production (GO:0032727)2.70486413
59platelet dense granule organization (GO:0060155)2.66888471
60negative regulation of monooxygenase activity (GO:0032769)2.66816968
61signal transduction involved in DNA damage checkpoint (GO:0072422)2.64445040
62signal transduction involved in DNA integrity checkpoint (GO:0072401)2.64445040
63positive regulation of interleukin-1 secretion (GO:0050716)2.64345113
64granulocyte activation (GO:0036230)2.63743737
65respiratory burst (GO:0045730)2.61818796
66anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.61790172
67response to interferon-beta (GO:0035456)2.60997276
68negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.60497825
69regulation of interleukin-1 secretion (GO:0050704)2.60032621
70regulation of dendritic cell antigen processing and presentation (GO:0002604)2.59978521
71positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.59036855
72signal transduction involved in cell cycle checkpoint (GO:0072395)2.58833976
73regulation of NF-kappaB import into nucleus (GO:0042345)2.57951907
74regulation of chemokine biosynthetic process (GO:0045073)2.57777274
75negative regulation of ligase activity (GO:0051352)2.57163899
76negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.57163899
77positive regulation of natural killer cell activation (GO:0032816)2.56803495
78wound healing, spreading of epidermal cells (GO:0035313)2.56637426
79negative regulation of cytokine production involved in immune response (GO:0002719)2.56589734
80regulation of podosome assembly (GO:0071801)2.56086372
81regulation of membrane protein ectodomain proteolysis (GO:0051043)2.55255427
82cellular response to zinc ion (GO:0071294)2.54712655
83regulation of interleukin-12 production (GO:0032655)2.54142817
84telomere maintenance via recombination (GO:0000722)2.54081627
85regulation of interferon-alpha production (GO:0032647)2.53860775
86telomere maintenance via semi-conservative replication (GO:0032201)2.53327401
87positive regulation of heat generation (GO:0031652)2.53287218
88cellular response to interferon-beta (GO:0035458)2.53146091
89translational termination (GO:0006415)2.51659422
90regulation of defense response to virus by host (GO:0050691)2.50438481
91leukocyte mediated cytotoxicity (GO:0001909)2.49744126
92defense response to protozoan (GO:0042832)2.49469836
93response to interferon-alpha (GO:0035455)2.49068999
94positive regulation of T-helper 1 type immune response (GO:0002827)2.47870659
95DNA replication initiation (GO:0006270)2.47426334
96viral transcription (GO:0019083)2.47186935
97cellular response to interferon-alpha (GO:0035457)2.46917613
98ribosomal small subunit biogenesis (GO:0042274)2.46870062
99regulation of cellular amino acid metabolic process (GO:0006521)2.46559117
100regulation of protein heterodimerization activity (GO:0043497)2.46174049
101cytokine biosynthetic process (GO:0042089)2.45284284
102production of molecular mediator involved in inflammatory response (GO:0002532)2.44995015
103regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.44828646
104detection of molecule of bacterial origin (GO:0032490)2.44708595
105regulation of RIG-I signaling pathway (GO:0039535)2.44516280
106regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.44133465
107NIK/NF-kappaB signaling (GO:0038061)2.44026969
108defense response to virus (GO:0051607)2.43678611
109DNA strand elongation involved in DNA replication (GO:0006271)2.43594755
110regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.43550062
111cytidine metabolic process (GO:0046087)2.42612171
112cytidine catabolic process (GO:0006216)2.42612171
113cytidine deamination (GO:0009972)2.42612171
114proteasome assembly (GO:0043248)2.42413800
115G1/S transition of mitotic cell cycle (GO:0000082)2.42292336
116cell cycle G1/S phase transition (GO:0044843)2.42292336
117necroptotic process (GO:0070266)2.41809439
118response to protozoan (GO:0001562)2.41578166
119natural killer cell activation involved in immune response (GO:0002323)2.40616308
120monocyte chemotaxis (GO:0002548)2.40523480
121antigen processing and presentation of endogenous antigen (GO:0019883)2.40203451
122tryptophan metabolic process (GO:0006568)2.39397827
123ribonucleoprotein complex biogenesis (GO:0022613)2.38565641
124positive regulation of natural killer cell differentiation (GO:0032825)2.38199718
125lymphocyte mediated immunity (GO:0002449)2.38157565
126IMP biosynthetic process (GO:0006188)2.37997115
127positive regulation of monocyte chemotaxis (GO:0090026)2.37733292
128regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.35829948
129positive regulation by symbiont of host defense response (GO:0052509)2.35527131
130modulation by symbiont of host defense response (GO:0052031)2.35527131
131modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.35527131
132modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.35527131
133positive regulation by organism of defense response of other organism involved in symbiotic interact2.35527131
134modulation by symbiont of host immune response (GO:0052553)2.35527131
135positive regulation of interleukin-12 production (GO:0032735)2.34549041
136positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.34145869
137regulation of T-helper 1 cell differentiation (GO:0045625)2.33552759
138CENP-A containing nucleosome assembly (GO:0034080)2.33459145
139regulation of vitamin metabolic process (GO:0030656)2.32912757
140regulation of interleukin-1 beta production (GO:0032651)2.32784943
141positive regulation of cell cycle arrest (GO:0071158)2.32669816
142positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.32616386
143negative regulation of interleukin-1 production (GO:0032692)2.32583115
144negative regulation of mast cell activation (GO:0033004)2.30276106
145DNA strand elongation (GO:0022616)2.30066043
146regulation of interferon-beta biosynthetic process (GO:0045357)2.29616794
147positive regulation of interleukin-1 beta production (GO:0032731)2.29480769
148eosinophil chemotaxis (GO:0048245)2.29473851
149actin nucleation (GO:0045010)2.29191088
150regulation of immunoglobulin secretion (GO:0051023)2.29132783
151DNA replication checkpoint (GO:0000076)2.28141896
152mitotic recombination (GO:0006312)2.27452954
153interferon-gamma-mediated signaling pathway (GO:0060333)2.26783689
154chromatin remodeling at centromere (GO:0031055)2.26742931
155IMP metabolic process (GO:0046040)2.25975302
156translational initiation (GO:0006413)2.25544278
157positive regulation of isotype switching (GO:0045830)2.25272177
158positive regulation of alpha-beta T cell proliferation (GO:0046641)2.24905789
159antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.24836824
160antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.24836824
161positive regulation of ligase activity (GO:0051351)2.23208366
162membrane raft organization (GO:0031579)2.22760463
163ribosome biogenesis (GO:0042254)2.22292637
164regulation of interleukin-12 biosynthetic process (GO:0045075)2.20969358
165mitotic metaphase plate congression (GO:0007080)2.20483793
166translational elongation (GO:0006414)2.20408186
167positive regulation of interferon-beta production (GO:0032728)2.18971195
168DNA deamination (GO:0045006)2.18101673
169regulation of translation in response to stress (GO:0043555)2.18011429
170regulation of response to interferon-gamma (GO:0060330)2.17602084
171SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.17521455
172cullin deneddylation (GO:0010388)2.17497644

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.24273936
2IRF8_21731497_ChIP-ChIP_J774_Mouse3.68908793
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.54057800
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.29278313
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.25321427
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.90402291
7GABP_17652178_ChIP-ChIP_JURKAT_Human2.73754290
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.66936641
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.66157961
10EGR1_19374776_ChIP-ChIP_THP-1_Human2.45988101
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.37115148
12FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.31663137
13TP63_17297297_ChIP-ChIP_HaCaT_Human2.27276692
14E2F4_17652178_ChIP-ChIP_JURKAT_Human2.21935324
15* ELK1_19687146_ChIP-ChIP_HELA_Human2.17705834
16MYC_19079543_ChIP-ChIP_MESCs_Mouse2.16382714
17SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.11207766
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.10193376
19SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.06998007
20JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.02529863
21FOXM1_23109430_ChIP-Seq_U2OS_Human2.02295011
22MYC_19030024_ChIP-ChIP_MESCs_Mouse2.00196484
23MYB_21317192_ChIP-Seq_ERMYB_Mouse1.98652213
24NELFA_20434984_ChIP-Seq_ESCs_Mouse1.96158061
25ETS1_20019798_ChIP-Seq_JURKAT_Human1.95495931
26MYC_18358816_ChIP-ChIP_MESCs_Mouse1.92936886
27FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.88185863
28VDR_23849224_ChIP-Seq_CD4+_Human1.85694534
29NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.83171554
30CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.82827993
31JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.82338986
32STAT4_19710469_ChIP-ChIP_TH1__Mouse1.79298746
33MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.77331754
34IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.76935457
35SPI1_23547873_ChIP-Seq_NB4_Human1.76564216
36RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.74122696
37CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.74000724
38* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.73862015
39FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.73428218
40CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.72411442
41GATA2_21666600_ChIP-Seq_HMVEC_Human1.72387491
42ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.70247310
43DCP1A_22483619_ChIP-Seq_HELA_Human1.67896172
44* IRF8_27001747_Chip-Seq_BMDM_Mouse1.66792285
45CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.63551756
46SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.60550470
47NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.59474479
48CJUN_26792858_Chip-Seq_BT549_Human1.59249806
49HOXB4_20404135_ChIP-ChIP_EML_Mouse1.58347681
50JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.57579017
51XRN2_22483619_ChIP-Seq_HELA_Human1.55668821
52SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.53663224
53TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.53189985
54ELF1_17652178_ChIP-ChIP_JURKAT_Human1.51544865
55BRD4_25478319_ChIP-Seq_HGPS_Human1.50924468
56ELK1_22589737_ChIP-Seq_MCF10A_Human1.50125734
57STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.47763186
58TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.46277873
59TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.44310460
60* SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.43094004
61GATA3_26560356_Chip-Seq_TH2_Human1.40219910
62STAT3_1855785_ChIP-Seq_MESCs_Mouse1.39198094
63EGR1_23403033_ChIP-Seq_LIVER_Mouse1.38780547
64MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.38461369
65VDR_22108803_ChIP-Seq_LS180_Human1.38076946
66SRF_21415370_ChIP-Seq_HL-1_Mouse1.37912436
67FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.36877631
68HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.35450717
69AR_21909140_ChIP-Seq_LNCAP_Human1.35088002
70NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.34679145
71TRIM28_21343339_ChIP-Seq_HEK293_Human1.33933531
72SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.32321540
73TFEB_21752829_ChIP-Seq_HELA_Human1.31485318
74TTF2_22483619_ChIP-Seq_HELA_Human1.31008009
75CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.29856623
76E2F1_21310950_ChIP-Seq_MCF-7_Human1.29424691
77STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.29293211
78NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.26117884
79VDR_24787735_ChIP-Seq_THP-1_Human1.24779708
80Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.23838317
81PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.23444656
82FOXP3_21729870_ChIP-Seq_TREG_Human1.22707135
83HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.21894460
84RARG_19884340_ChIP-ChIP_MEFs_Mouse1.21804161
85GABP_19822575_ChIP-Seq_HepG2_Human1.21737629
86FLI1_27457419_Chip-Seq_LIVER_Mouse1.20749733
87PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.20001967
88ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.18803221
89STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.18313259
90* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.18284130
91NOTCH1_21737748_ChIP-Seq_TLL_Human1.17531461
92LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.17347765
93TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.16852985
94* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.15290359
95NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.15013082
96POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.14856092
97MYB_26560356_Chip-Seq_TH2_Human1.14100799
98HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.11597297
99NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.09447649
100SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.08231386
101SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.08231386
102CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.07749842
103CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.07578517
104POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.05684874
105* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.05049472
106BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.04738796
107BRD4_27068464_Chip-Seq_AML-cells_Mouse1.04643546
108ZNF274_21170338_ChIP-Seq_K562_Hela1.03804088
109CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01171313
110SMAD_19615063_ChIP-ChIP_OVARY_Human1.00805709
111ELF5_23300383_ChIP-Seq_T47D_Human1.00762455
112MYCN_18555785_ChIP-Seq_MESCs_Mouse1.00603432
113MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.00090982
114TCF3_18692474_ChIP-Seq_MEFs_Mouse0.98731996
115PCGF2_27294783_Chip-Seq_ESCs_Mouse0.97294607
116HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.96839081
117CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96620897
118PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93585753
119RUNX1_22412390_ChIP-Seq_EML_Mouse0.93076694
120ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.92991547
121RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.92909578
122MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.92763247
123FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.92671386
124TP53_16413492_ChIP-PET_HCT116_Human0.92372257
125STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.91782688
126YY1_21170310_ChIP-Seq_MESCs_Mouse0.91239808
127SALL4_18804426_ChIP-ChIP_XEN_Mouse0.90872636
128PPAR_26484153_Chip-Seq_NCI-H1993_Human0.90591397
129EZH2_27294783_Chip-Seq_NPCs_Mouse0.89863210
130PU_27001747_Chip-Seq_BMDM_Mouse0.89770363
131CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.88405995
132LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.87735676
133CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.84014611
134NRF2_20460467_ChIP-Seq_MEFs_Mouse0.81808945
135NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.81808945
136GATA1_22025678_ChIP-Seq_K562_Human0.79305189
137NFE2_27457419_Chip-Seq_LIVER_Mouse0.78706049
138CRX_20693478_ChIP-Seq_RETINA_Mouse0.78382383

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003950_abnormal_plasma_membrane3.82823345
2MP0003806_abnormal_nucleotide_metabolis3.58890268
3MP0001835_abnormal_antigen_presentation3.38451386
4MP0009785_altered_susceptibility_to2.94832741
5MP0002148_abnormal_hypersensitivity_rea2.88909316
6MP0008438_abnormal_cutaneous_collagen2.76213553
7MP0003436_decreased_susceptibility_to2.72511221
8MP0003693_abnormal_embryo_hatching2.47215672
9MP0000569_abnormal_digit_pigmentation2.41574999
10MP0005275_abnormal_skin_tensile2.41177781
11MP0003724_increased_susceptibility_to2.31246941
12MP0005000_abnormal_immune_tolerance2.25125348
13MP0009333_abnormal_splenocyte_physiolog2.22511619
14MP0000685_abnormal_immune_system2.11979575
15MP0005671_abnormal_response_to2.10150262
16MP0002419_abnormal_innate_immunity2.03749818
17MP0004957_abnormal_blastocyst_morpholog2.03589489
18MP0010352_gastrointestinal_tract_polyps2.02569206
19MP0003191_abnormal_cellular_cholesterol2.02170982
20MP0005025_abnormal_response_to2.00610000
21MP0002452_abnormal_antigen_presenting1.92720022
22MP0002254_reproductive_system_inflammat1.88436537
23MP0003448_altered_tumor_morphology1.88238193
24MP0010094_abnormal_chromosome_stability1.84211224
25MP0009840_abnormal_foam_cell1.83882927
26MP0003077_abnormal_cell_cycle1.80205110
27MP0002006_tumorigenesis1.80144824
28MP0003566_abnormal_cell_adhesion1.79365869
29MP0002723_abnormal_immune_serum1.79308046
30MP0000858_altered_metastatic_potential1.75636468
31MP0005503_abnormal_tendon_morphology1.74888747
32MP0001800_abnormal_humoral_immune1.74817779
33MP0003195_calcinosis1.74729637
34MP0000343_altered_response_to1.74586691
35MP0001542_abnormal_bone_strength1.72954924
36MP0001819_abnormal_immune_cell1.72029196
37MP0002420_abnormal_adaptive_immunity1.70652318
38MP0003646_muscle_fatigue1.67845873
39MP0005023_abnormal_wound_healing1.67668769
40MP0002405_respiratory_system_inflammati1.64609952
41MP0002396_abnormal_hematopoietic_system1.61912352
42MP0001790_abnormal_immune_system1.61300435
43MP0005387_immune_system_phenotype1.61300435
44MP0001853_heart_inflammation1.59283493
45MP0001533_abnormal_skeleton_physiology1.59217495
46MP0003186_abnormal_redox_activity1.59168509
47MP0003111_abnormal_nucleus_morphology1.58360200
48MP0002332_abnormal_exercise_endurance1.57983897
49MP0008007_abnormal_cellular_replicative1.57834535
50MP0005397_hematopoietic_system_phenotyp1.56421772
51MP0001545_abnormal_hematopoietic_system1.56421772
52MP0010307_abnormal_tumor_latency1.50503504
53MP0002837_dystrophic_cardiac_calcinosis1.49979877
54MP0006082_CNS_inflammation1.44433160
55MP0005058_abnormal_lysosome_morphology1.42735738
56MP0008058_abnormal_DNA_repair1.40837645
57MP0005165_increased_susceptibility_to1.40811591
58MP0002398_abnormal_bone_marrow1.38376857
59MP0002166_altered_tumor_susceptibility1.38285530
60MP0002138_abnormal_hepatobiliary_system1.38063919
61MP0003075_altered_response_to1.37094926
62MP0000749_muscle_degeneration1.32342679
63MP0004947_skin_inflammation1.32018415
64MP0003300_gastrointestinal_ulcer1.30894181
65MP0001845_abnormal_inflammatory_respons1.30810028
66MP0004084_abnormal_cardiac_muscle1.30491354
67MP0000716_abnormal_immune_system1.29601341
68MP0003091_abnormal_cell_migration1.28808144
69MP0010155_abnormal_intestine_physiology1.28401092
70MP0003786_premature_aging1.27646404
71MP0004808_abnormal_hematopoietic_stem1.27194439
72MP0008057_abnormal_DNA_replication1.26738247
73MP0003763_abnormal_thymus_physiology1.26416026
74MP0008932_abnormal_embryonic_tissue1.25619561
75MP0001958_emphysema1.21802430
76MP0003279_aneurysm1.19446821
77MP0000689_abnormal_spleen_morphology1.18737789
78MP0005390_skeleton_phenotype1.17071962
79MP0002429_abnormal_blood_cell1.16019098
80MP0000490_abnormal_crypts_of1.15560157
81MP0005464_abnormal_platelet_physiology1.14282244
82MP0002722_abnormal_immune_system1.14031706
83MP0008004_abnormal_stomach_pH1.12622654
84MP0003705_abnormal_hypodermis_morpholog1.10826815
85MP0001243_abnormal_dermal_layer1.10752837
86MP0009278_abnormal_bone_marrow1.09364333
87MP0003303_peritoneal_inflammation1.07425380
88MP0002019_abnormal_tumor_incidence1.06475704
89MP0008260_abnormal_autophagy1.06455180
90MP0005330_cardiomyopathy1.06270110
91MP0005164_abnormal_response_to1.05298844
92MP0006054_spinal_hemorrhage1.04217278
93MP0002277_abnormal_respiratory_mucosa1.04208394
94MP0005451_abnormal_body_composition1.03981705
95MP0001879_abnormal_lymphatic_vessel1.02104755
96MP0000350_abnormal_cell_proliferation1.02039148
97MP0009764_decreased_sensitivity_to0.99920876
98MP0002933_joint_inflammation0.99858211
99MP0002998_abnormal_bone_remodeling0.96649348
100MP0009763_increased_sensitivity_to0.94477241
101MP0000371_diluted_coat_color0.93935262
102MP0008469_abnormal_protein_level0.93474339
103MP0003828_pulmonary_edema0.93133195
104MP0005166_decreased_susceptibility_to0.92629568
105MP0005084_abnormal_gallbladder_morpholo0.91822491
106MP0003252_abnormal_bile_duct0.90787298
107MP0000750_abnormal_muscle_regeneration0.88492293
108MP0003941_abnormal_skin_development0.87896960
109MP0004272_abnormal_basement_membrane0.86939111
110MP0000627_abnormal_mammary_gland0.86850155
111MP0005076_abnormal_cell_differentiation0.82735897
112MP0004782_abnormal_surfactant_physiolog0.81937795
113MP0000372_irregular_coat_pigmentation0.81280939
114MP0000313_abnormal_cell_death0.81107441
115MP0005266_abnormal_metabolism0.79926794
116MP0002972_abnormal_cardiac_muscle0.79761221
117MP0005621_abnormal_cell_physiology0.79698088
118MP0003718_maternal_effect0.78774223
119MP0001873_stomach_inflammation0.77803012
120MP0000703_abnormal_thymus_morphology0.77745178
121MP0004510_myositis0.77574197
122MP0002877_abnormal_melanocyte_morpholog0.75678901
123MP0003795_abnormal_bone_structure0.74632470
124MP0000249_abnormal_blood_vessel0.74630675
125MP0004883_abnormal_blood_vessel0.74479911
126MP0002060_abnormal_skin_morphology0.74454571
127MP0003453_abnormal_keratinocyte_physiol0.73718582
128MP0001730_embryonic_growth_arrest0.73474790
129MP0002295_abnormal_pulmonary_circulatio0.73282788
130MP0005595_abnormal_vascular_smooth0.72756941
131MP0005623_abnormal_meninges_morphology0.72722199
132MP0002139_abnormal_hepatobiliary_system0.72199469
133MP0005167_abnormal_blood-brain_barrier0.72055951
134MP0004036_abnormal_muscle_relaxation0.72003097
135MP0010368_abnormal_lymphatic_system0.71380991
136MP0005376_homeostasis/metabolism_phenot0.70963869
137MP0006036_abnormal_mitochondrial_physio0.70946741
138MP0000767_abnormal_smooth_muscle0.70677807
139MP0008875_abnormal_xenobiotic_pharmacok0.69448919
140MP0009765_abnormal_xenobiotic_induced0.68487348

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glycolipid metabolism (HP:0010969)4.52243719
2Abnormality of liposaccharide metabolism (HP:0010968)4.52243719
3Abnormality of glycosphingolipid metabolism (HP:0004343)4.52243719
4Recurrent abscess formation (HP:0002722)4.46996929
5Eczematoid dermatitis (HP:0000976)4.24915643
6Recurrent bacterial skin infections (HP:0005406)3.66169605
7Elevated erythrocyte sedimentation rate (HP:0003565)3.46621091
8Vertebral compression fractures (HP:0002953)3.36678639
9Birth length less than 3rd percentile (HP:0003561)3.34294563
10Myositis (HP:0100614)3.23987878
11Increased IgM level (HP:0003496)3.17892111
12Premature rupture of membranes (HP:0001788)3.13554462
13Reticulocytopenia (HP:0001896)3.11573837
14Thrombocytosis (HP:0001894)3.07054275
15Osteolytic defects of the hand bones (HP:0009699)3.01855965
16Osteolytic defects of the phalanges of the hand (HP:0009771)3.01855965
17Mediastinal lymphadenopathy (HP:0100721)2.93279972
18Orchitis (HP:0100796)2.87465206
19Autoimmune thrombocytopenia (HP:0001973)2.82921615
20Abnormality of macrophages (HP:0004311)2.82757533
21Amniotic constriction ring (HP:0009775)2.78518469
22Abnormality of placental membranes (HP:0011409)2.78518469
23Cervical subluxation (HP:0003308)2.69836971
24Optic neuritis (HP:0100653)2.68403947
25Retrobulbar optic neuritis (HP:0100654)2.68403947
26Loss of speech (HP:0002371)2.66863891
27Protrusio acetabuli (HP:0003179)2.63997468
28Agnosia (HP:0010524)2.62310875
29Poor head control (HP:0002421)2.57109248
30Chromsome breakage (HP:0040012)2.51984147
31Prostate neoplasm (HP:0100787)2.51955754
32Autoimmune hemolytic anemia (HP:0001890)2.44136006
33Recurrent gram-negative bacterial infections (HP:0005420)2.43956253
343-Methylglutaconic aciduria (HP:0003535)2.43499939
35Amyloidosis (HP:0011034)2.42713349
36Nausea (HP:0002018)2.42404823
37T lymphocytopenia (HP:0005403)2.41469989
38Chromosomal breakage induced by crosslinking agents (HP:0003221)2.39975980
39Myocardial infarction (HP:0001658)2.39658528
40Biconcave vertebral bodies (HP:0004586)2.38052561
41Breast hypoplasia (HP:0003187)2.35736360
42Parakeratosis (HP:0001036)2.35486764
43Peritonitis (HP:0002586)2.32689697
44Obstructive lung disease (HP:0006536)2.30745887
45Chronic obstructive pulmonary disease (HP:0006510)2.30745887
46Type I transferrin isoform profile (HP:0003642)2.30399087
47Anorexia (HP:0002039)2.27331778
48Recurrent fungal infections (HP:0002841)2.24168600
49Generalized aminoaciduria (HP:0002909)2.23097644
50Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.22677411
51Stomatitis (HP:0010280)2.19010652
52Abnormal delayed hypersensitivity skin test (HP:0002963)2.15872502
53Aplastic anemia (HP:0001915)2.15451372
54Increased cerebral lipofuscin (HP:0011813)2.13844119
55Hypergammaglobulinemia (HP:0010702)2.13347712
56Polyneuropathy (HP:0001271)2.10629499
57Abnormal protein glycosylation (HP:0012346)2.10290150
58Abnormal glycosylation (HP:0012345)2.10290150
59Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.10290150
60Abnormal protein N-linked glycosylation (HP:0012347)2.10290150
61Vasculitis (HP:0002633)2.09277064
62Albinism (HP:0001022)2.08998187
63Keratoconjunctivitis (HP:0001096)2.08684149
64Rough bone trabeculation (HP:0100670)2.07167230
65Recurrent viral infections (HP:0004429)2.07032615
66Neoplasm of head and neck (HP:0012288)2.06220356
67Esophageal neoplasm (HP:0100751)2.06220356
68Dysostosis multiplex (HP:0000943)2.05861421
69Hemoptysis (HP:0002105)2.05062215
70Trismus (HP:0000211)2.04448712
71Cellulitis (HP:0100658)2.02949329
72Recurrent skin infections (HP:0001581)2.02261518
73Increased CSF lactate (HP:0002490)2.02198737
74Ankle contracture (HP:0006466)2.00008102
75Cortical dysplasia (HP:0002539)1.99116366
76Syringomyelia (HP:0003396)1.97074496
77Spinal cord lesions (HP:0100561)1.97074496
78Petechiae (HP:0000967)1.96789333
79Congenital, generalized hypertrichosis (HP:0004540)1.94588007
80Amaurosis fugax (HP:0100576)1.93709356
81Abnormality of the calcaneus (HP:0008364)1.92129554
82Abnormality of polysaccharide metabolism (HP:0011012)1.90965773
83Abnormality of glycosaminoglycan metabolism (HP:0004371)1.90965773
84Abnormality of mucopolysaccharide metabolism (HP:0011020)1.90965773
85Mitochondrial inheritance (HP:0001427)1.89156059
86Leukocytosis (HP:0001974)1.88962217
87Abnormality of the prostate (HP:0008775)1.88883739
88Osteomyelitis (HP:0002754)1.88877987
89Hepatocellular necrosis (HP:0001404)1.87826320
90Basal ganglia calcification (HP:0002135)1.87538484
91Gangrene (HP:0100758)1.87052352
92Gingivitis (HP:0000230)1.84656858
93Delayed gross motor development (HP:0002194)1.83864646
94Acute necrotizing encephalopathy (HP:0006965)1.83130633
95Distal lower limb muscle weakness (HP:0009053)1.83019033
96Disinhibition (HP:0000734)1.82808634
97Abnormality of the pons (HP:0007361)1.82622769
98Abnormality of T cells (HP:0002843)1.82618433
99Hepatosplenomegaly (HP:0001433)1.80804825
100Muscle fiber atrophy (HP:0100295)1.80614292
101Intrahepatic cholestasis (HP:0001406)1.80600281
102Degeneration of anterior horn cells (HP:0002398)1.80435660
103Abnormality of the anterior horn cell (HP:0006802)1.80435660
104Abnormal trabecular bone morphology (HP:0100671)1.79392400
105Interstitial pulmonary disease (HP:0006530)1.79391433
106Increased neuronal autofluorescent lipopigment (HP:0002074)1.78823224
107Pallor (HP:0000980)1.78782591
108Increased serum ferritin (HP:0003281)1.78742746
109Urticaria (HP:0001025)1.78494221
110Pulmonary infiltrates (HP:0002113)1.78319867
111Abnormality of T cell physiology (HP:0011840)1.78208873
112Meckel diverticulum (HP:0002245)1.77919234
113Pustule (HP:0200039)1.77733334
114Skin ulcer (HP:0200042)1.77290889
115Reduced subcutaneous adipose tissue (HP:0003758)1.77265336
116Abnormality of chromosome stability (HP:0003220)1.77007510
117IgA deficiency (HP:0002720)1.76707160
118Vacuolated lymphocytes (HP:0001922)1.75630073
119Gastrointestinal infarctions (HP:0005244)1.75603477
120Decreased subcutaneous fat (HP:0001002)1.75190381
121Myelodysplasia (HP:0002863)1.75138325
122Hepatic necrosis (HP:0002605)1.75019316
123Recurrent lower respiratory tract infections (HP:0002783)1.74080480
124Pulmonary fibrosis (HP:0002206)1.73971544
125Recurrent pneumonia (HP:0006532)1.73718654
126Nuclear cataract (HP:0100018)1.73414279
127Eosinophilia (HP:0001880)1.73384535
128IgG deficiency (HP:0004315)1.73106947
129Carpal bone hypoplasia (HP:0001498)1.72321323
130Abnormality of the preputium (HP:0100587)1.72049515
131Facial diplegia (HP:0001349)1.71501116
132Hematochezia (HP:0002573)1.70948723
133Type 2 muscle fiber atrophy (HP:0003554)1.70623139
13411 pairs of ribs (HP:0000878)1.69786270
135Increased connective tissue (HP:0009025)1.69684585
136Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.69486731
137Keratoconjunctivitis sicca (HP:0001097)1.68837308
138Wormian bones (HP:0002645)1.68328725
139Spondylolisthesis (HP:0003302)1.68018709
140Atrophic scars (HP:0001075)1.66811420
141Granulocytopenia (HP:0001913)1.66577944
142Absent thumb (HP:0009777)1.66298783
143Reduced antithrombin III activity (HP:0001976)1.66298220
144Entropion (HP:0000621)1.66071173
145Selective tooth agenesis (HP:0001592)1.64913535
146Tetraparesis (HP:0002273)1.64729819
147Palpitations (HP:0001962)1.64724821
148Abnormality of T cell number (HP:0011839)1.64431973
149Short nail (HP:0001799)1.64398892
150Abnormality of the pericardium (HP:0001697)1.64348135
151Wrist flexion contracture (HP:0001239)1.64336630
152Nemaline bodies (HP:0003798)1.64199317
153Fused cervical vertebrae (HP:0002949)1.64117438
154Urinary glycosaminoglycan excretion (HP:0003541)1.63926073
155Mucopolysacchariduria (HP:0008155)1.63926073
156Porencephaly (HP:0002132)1.63874104
157Follicular hyperkeratosis (HP:0007502)1.62740120
158Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.62708093
159Abnormality of alanine metabolism (HP:0010916)1.62708093
160Hyperalaninemia (HP:0003348)1.62708093
161Acute encephalopathy (HP:0006846)1.61758421

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME23.36580637
2MAP3K143.01025361
3PIM22.99267183
4ACVR1B2.72127265
5EIF2AK12.67956836
6EIF2AK32.56839312
7BUB12.41358789
8WEE12.26563775
9TESK12.23306065
10MST42.23113274
11PBK2.15946960
12MAPKAPK32.15532631
13TGFBR22.14992313
14GRK72.08488999
15ADRBK22.06162033
16TESK21.98645162
17TXK1.91329198
18BLK1.84596749
19JAK31.69246353
20ZAP701.65459103
21FRK1.64784992
22MUSK1.64090822
23TIE11.63001069
24IKBKB1.62514252
25MAP4K21.60160146
26TBK11.59934614
27IRAK41.59233373
28RPS6KA41.52951989
29ZAK1.47276747
30TYK21.46157257
31TRPM71.46051805
32PIM11.44622492
33TEC1.43540841
34LIMK11.35887535
35TGFBR11.35749939
36EPHA21.32719288
37EIF2AK21.31612454
38MATK1.30456370
39KDR1.25549781
40RIPK41.25479939
41KIT1.24385087
42MST1R1.23164283
43LRRK21.22935067
44NEK91.22318682
45VRK21.19876946
46OXSR11.19086096
47STK101.18872419
48CDK191.15259687
49MOS1.15081606
50MAP4K11.13782630
51CDC71.11550106
52ERBB31.09249225
53ARAF1.07087545
54ERBB41.04921379
55BRSK21.04499091
56IKBKE1.03455293
57STK161.02622503
58MAP3K31.02334740
59MAP3K121.02325500
60NUAK11.00414453
61TTN1.00152996
62PLK10.99763166
63PLK40.99563229
64IRAK30.98440226
65PDK20.97707098
66TAOK20.96897340
67NEK10.95594564
68AURKB0.91351170
69ADRBK10.90499601
70MAP2K30.90215123
71TSSK60.87020673
72MKNK10.84278790
73MYLK0.83898466
74PAK40.83793930
75FGR0.83589300
76ABL20.83441215
77RPS6KB20.82705839
78BMX0.80865591
79CHUK0.78146878
80PLK30.77917840
81GRK10.75091867
82CLK10.74613452
83TAOK30.73216267
84SYK0.72803546
85CSK0.71056167
86BTK0.70944746
87MAP3K80.68984425
88VRK10.66327736
89STK40.65659378
90LYN0.64872392
91ATR0.64850071
92FLT30.64098827
93JAK10.63650806
94TTK0.61442917
95MAP3K50.61070404
96MELK0.61069909
97LCK0.60795071
98TLK10.57502515
99CAMKK20.57135698
100TRIM280.56236953
101STK38L0.56156316
102PAK10.55267768
103BMPR1B0.54421655
104PTK2B0.53502985
105SIK30.52723213
106BMPR20.52680271
107CDK70.52605868
108NEK20.51764739
109MET0.51737148
110HCK0.51215167
111YES10.50688508
112MARK30.49655372
113AURKA0.47585660
114MAPKAPK20.47185063
115ITK0.46113989
116PDK40.46043490
117PDK30.46043490
118CDC42BPA0.45353941
119MAP3K110.45310230
120FER0.45303825
121STK240.45141395
122BRAF0.44828759
123ABL10.44622805
124SRPK10.44483243
125OBSCN0.43580737
126PLK20.41254014
127DAPK30.41156183
128PIK3CG0.41022295
129DDR20.40914979
130CSNK2A10.40837156
131PRKCD0.39722494
132CCNB10.38779438
133STK30.38488456
134ROCK10.36163751
135IRAK10.33558076

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.71792740
2DNA replication_Homo sapiens_hsa030302.69908054
3Ribosome_Homo sapiens_hsa030102.62549402
4Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.41920756
5Graft-versus-host disease_Homo sapiens_hsa053322.33909530
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.28761604
7Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.16065473
8Mismatch repair_Homo sapiens_hsa034302.15993555
9Allograft rejection_Homo sapiens_hsa053302.15759174
10Leishmaniasis_Homo sapiens_hsa051402.02318888
11Legionellosis_Homo sapiens_hsa051342.00392266
12RNA polymerase_Homo sapiens_hsa030201.97764905
13NF-kappa B signaling pathway_Homo sapiens_hsa040641.76879314
14Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.70324618
15Primary bile acid biosynthesis_Homo sapiens_hsa001201.69338568
16Malaria_Homo sapiens_hsa051441.67444281
17Nucleotide excision repair_Homo sapiens_hsa034201.60185969
18Sulfur metabolism_Homo sapiens_hsa009201.59023064
19Base excision repair_Homo sapiens_hsa034101.58157267
20Pyrimidine metabolism_Homo sapiens_hsa002401.57186072
21p53 signaling pathway_Homo sapiens_hsa041151.56586612
22Homologous recombination_Homo sapiens_hsa034401.54510244
23Measles_Homo sapiens_hsa051621.53494585
24Rheumatoid arthritis_Homo sapiens_hsa053231.53002555
25Antigen processing and presentation_Homo sapiens_hsa046121.52492001
26RNA transport_Homo sapiens_hsa030131.51997596
27NOD-like receptor signaling pathway_Homo sapiens_hsa046211.50983301
28Cell cycle_Homo sapiens_hsa041101.46873198
29Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.46589757
30Shigellosis_Homo sapiens_hsa051311.46053005
31RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.40763538
32Herpes simplex infection_Homo sapiens_hsa051681.40601313
33Toll-like receptor signaling pathway_Homo sapiens_hsa046201.35363728
34Glycosaminoglycan degradation_Homo sapiens_hsa005311.32334501
35Intestinal immune network for IgA production_Homo sapiens_hsa046721.31615304
36Salmonella infection_Homo sapiens_hsa051321.31420142
37Apoptosis_Homo sapiens_hsa042101.30778870
38Pertussis_Homo sapiens_hsa051331.29728421
39Epstein-Barr virus infection_Homo sapiens_hsa051691.29311992
40Hematopoietic cell lineage_Homo sapiens_hsa046401.26572952
41Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.24702007
42Phagosome_Homo sapiens_hsa041451.22012060
43Spliceosome_Homo sapiens_hsa030401.21792262
44TNF signaling pathway_Homo sapiens_hsa046681.20709738
45Influenza A_Homo sapiens_hsa051641.20441288
46Viral myocarditis_Homo sapiens_hsa054161.19018226
47Type I diabetes mellitus_Homo sapiens_hsa049401.18286324
48One carbon pool by folate_Homo sapiens_hsa006701.14519037
49Tuberculosis_Homo sapiens_hsa051521.13582840
50Autoimmune thyroid disease_Homo sapiens_hsa053201.10014824
51Osteoclast differentiation_Homo sapiens_hsa043801.09092105
52Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.08432878
53Asthma_Homo sapiens_hsa053101.06069138
54Toxoplasmosis_Homo sapiens_hsa051451.05288843
55Fanconi anemia pathway_Homo sapiens_hsa034601.02927928
56Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.02499255
57Basal transcription factors_Homo sapiens_hsa030221.02063681
58Primary immunodeficiency_Homo sapiens_hsa053401.01159292
59RNA degradation_Homo sapiens_hsa030181.00484068
60Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.99655399
61Non-homologous end-joining_Homo sapiens_hsa034500.98423627
62Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.95569783
63Jak-STAT signaling pathway_Homo sapiens_hsa046300.91701754
64Other glycan degradation_Homo sapiens_hsa005110.87044982
65African trypanosomiasis_Homo sapiens_hsa051430.83612999
66Viral carcinogenesis_Homo sapiens_hsa052030.83396554
67Leukocyte transendothelial migration_Homo sapiens_hsa046700.81444433
68Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.81086147
69Hepatitis B_Homo sapiens_hsa051610.81008606
70Tryptophan metabolism_Homo sapiens_hsa003800.79475553
71Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.77075872
72Small cell lung cancer_Homo sapiens_hsa052220.76582652
73Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.76580885
74Selenocompound metabolism_Homo sapiens_hsa004500.72611173
75AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.71384785
76Purine metabolism_Homo sapiens_hsa002300.70929569
77Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.70855119
78Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.70318517
79Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.69948880
80HTLV-I infection_Homo sapiens_hsa051660.69809049
81Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.68177768
82Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.66946299
83Complement and coagulation cascades_Homo sapiens_hsa046100.66307213
84HIF-1 signaling pathway_Homo sapiens_hsa040660.65362980
85Alzheimers disease_Homo sapiens_hsa050100.60325226
86Sphingolipid metabolism_Homo sapiens_hsa006000.59867915
87Protein export_Homo sapiens_hsa030600.57354580
88Lysosome_Homo sapiens_hsa041420.57048635
89Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.56964555
90Arachidonic acid metabolism_Homo sapiens_hsa005900.55462946
91ECM-receptor interaction_Homo sapiens_hsa045120.55181962
92Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.55170473
93Amoebiasis_Homo sapiens_hsa051460.54641641
94Systemic lupus erythematosus_Homo sapiens_hsa053220.53995913
95Staphylococcus aureus infection_Homo sapiens_hsa051500.52260424
96SNARE interactions in vesicular transport_Homo sapiens_hsa041300.51098196
97Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.50644524
98Chemokine signaling pathway_Homo sapiens_hsa040620.50382566
99Cysteine and methionine metabolism_Homo sapiens_hsa002700.48873790
100MicroRNAs in cancer_Homo sapiens_hsa052060.47189910
101Proteoglycans in cancer_Homo sapiens_hsa052050.46074546
102Caffeine metabolism_Homo sapiens_hsa002320.44282055
103Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.44269307
104Glutathione metabolism_Homo sapiens_hsa004800.44192003
105Focal adhesion_Homo sapiens_hsa045100.44177359
106Adherens junction_Homo sapiens_hsa045200.44136073
107Pyruvate metabolism_Homo sapiens_hsa006200.42383652
108Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.41990863
109Hepatitis C_Homo sapiens_hsa051600.41573176
110Galactose metabolism_Homo sapiens_hsa000520.41404335
111Oxidative phosphorylation_Homo sapiens_hsa001900.40958248
112Drug metabolism - other enzymes_Homo sapiens_hsa009830.40316141
113Renin-angiotensin system_Homo sapiens_hsa046140.39606356
114Propanoate metabolism_Homo sapiens_hsa006400.39133321
115Parkinsons disease_Homo sapiens_hsa050120.39083428
116TGF-beta signaling pathway_Homo sapiens_hsa043500.38877588
117Platelet activation_Homo sapiens_hsa046110.38332858
118Regulation of actin cytoskeleton_Homo sapiens_hsa048100.37880012
119alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.37359636
120Regulation of autophagy_Homo sapiens_hsa041400.37258105
121Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.36917795
122Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.36611306
123Huntingtons disease_Homo sapiens_hsa050160.35733966
124B cell receptor signaling pathway_Homo sapiens_hsa046620.34931846
125Mineral absorption_Homo sapiens_hsa049780.34097252
126Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.33921925
127Fatty acid elongation_Homo sapiens_hsa000620.33856087
128Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.31594606

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