ACOX1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is the first enzyme of the fatty acid beta-oxidation pathway, which catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs. It donates electrons directly to molecular oxygen, thereby producing hydrogen peroxide. Defects in this gene result in pseudoneonatal adrenoleukodystrophy, a disease that is characterized by accumulation of very long chain fatty acids. Alternatively spliced transcript variants encoding different isoforms have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)7.04886407
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.04886407
3L-phenylalanine metabolic process (GO:0006558)6.73663533
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.73663533
5aromatic amino acid family catabolic process (GO:0009074)6.28582217
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.86346508
7tryptophan catabolic process (GO:0006569)5.66726857
8indole-containing compound catabolic process (GO:0042436)5.66726857
9indolalkylamine catabolic process (GO:0046218)5.66726857
10kynurenine metabolic process (GO:0070189)5.58838808
11glyoxylate metabolic process (GO:0046487)5.54776050
12bile acid biosynthetic process (GO:0006699)5.49154377
13* alpha-linolenic acid metabolic process (GO:0036109)5.41780423
14tryptophan metabolic process (GO:0006568)5.33551180
15epoxygenase P450 pathway (GO:0019373)5.32991079
16cysteine metabolic process (GO:0006534)5.19692327
17urea metabolic process (GO:0019627)5.13698188
18urea cycle (GO:0000050)5.13698188
19sulfur amino acid catabolic process (GO:0000098)5.10435074
20lysine metabolic process (GO:0006553)4.94519604
21lysine catabolic process (GO:0006554)4.94519604
22high-density lipoprotein particle remodeling (GO:0034375)4.88846494
23negative regulation of fibrinolysis (GO:0051918)4.81902660
24complement activation, alternative pathway (GO:0006957)4.81226411
25serine family amino acid catabolic process (GO:0009071)4.74495594
26bile acid metabolic process (GO:0008206)4.73794300
27peptidyl-glutamic acid carboxylation (GO:0017187)4.73728946
28protein carboxylation (GO:0018214)4.73728946
29nitrogen cycle metabolic process (GO:0071941)4.73052659
30regulation of protein activation cascade (GO:2000257)4.71919362
31regulation of triglyceride catabolic process (GO:0010896)4.68465786
32* fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.65275081
33amino-acid betaine metabolic process (GO:0006577)4.63612382
34homocysteine metabolic process (GO:0050667)4.63057424
35regulation of fibrinolysis (GO:0051917)4.62718593
36aromatic amino acid family metabolic process (GO:0009072)4.54957812
37cellular ketone body metabolic process (GO:0046950)4.52132956
38alpha-amino acid catabolic process (GO:1901606)4.42930199
39tyrosine metabolic process (GO:0006570)4.40800993
40regulation of complement activation (GO:0030449)4.40492341
41triglyceride homeostasis (GO:0070328)4.38646156
42acylglycerol homeostasis (GO:0055090)4.38646156
43reverse cholesterol transport (GO:0043691)4.37566475
44regulation of cholesterol esterification (GO:0010872)4.34044714
45macromolecular complex remodeling (GO:0034367)4.30296891
46plasma lipoprotein particle remodeling (GO:0034369)4.30296891
47protein-lipid complex remodeling (GO:0034368)4.30296891
48glutamate metabolic process (GO:0006536)4.20153068
49negative regulation of sterol transport (GO:0032372)4.19709525
50negative regulation of cholesterol transport (GO:0032375)4.19709525
51coenzyme catabolic process (GO:0009109)4.16537693
52plasma lipoprotein particle clearance (GO:0034381)4.15148045
53cellular amino acid catabolic process (GO:0009063)4.14699995
54phospholipid efflux (GO:0033700)4.14312409
55drug catabolic process (GO:0042737)4.06108492
56ethanol oxidation (GO:0006069)4.04254329
57cellular modified amino acid catabolic process (GO:0042219)4.02895575
58acetyl-CoA metabolic process (GO:0006084)4.01062793
59intestinal absorption (GO:0050892)4.00738919
60bile acid and bile salt transport (GO:0015721)4.00695492
61short-chain fatty acid metabolic process (GO:0046459)4.00444953
62omega-hydroxylase P450 pathway (GO:0097267)4.00375063
63indolalkylamine metabolic process (GO:0006586)4.00145011
64cellular glucuronidation (GO:0052695)3.93525545
65dicarboxylic acid biosynthetic process (GO:0043650)3.93423043
66ketone body metabolic process (GO:1902224)3.91788225
67benzene-containing compound metabolic process (GO:0042537)3.86741578
68cellular biogenic amine catabolic process (GO:0042402)3.86064900
69amine catabolic process (GO:0009310)3.86064900
70serine family amino acid metabolic process (GO:0009069)3.85261024
71cholesterol efflux (GO:0033344)3.83558517
72positive regulation of lipid catabolic process (GO:0050996)3.82405628
73glycine metabolic process (GO:0006544)3.78843370
74positive regulation of fatty acid beta-oxidation (GO:0032000)3.77997385
75* fatty acid beta-oxidation (GO:0006635)3.77448361
76drug transmembrane transport (GO:0006855)3.77267543
77angiotensin maturation (GO:0002003)3.77049840
782-oxoglutarate metabolic process (GO:0006103)3.74560212
79* carboxylic acid catabolic process (GO:0046395)3.73984025
80* organic acid catabolic process (GO:0016054)3.73984025
81phospholipid homeostasis (GO:0055091)3.73533061
82* fatty acid oxidation (GO:0019395)3.72416674
83imidazole-containing compound metabolic process (GO:0052803)3.72108260
84lipoprotein transport (GO:0042953)3.71427147
85aspartate family amino acid catabolic process (GO:0009068)3.68400609
86drug metabolic process (GO:0017144)3.68088302
87plasma lipoprotein particle assembly (GO:0034377)3.67751998
88flavonoid metabolic process (GO:0009812)3.67557005
89* lipid oxidation (GO:0034440)3.65788390
90* monocarboxylic acid catabolic process (GO:0072329)3.64540311
91arginine metabolic process (GO:0006525)3.62450395
92regulation of bile acid biosynthetic process (GO:0070857)3.62003213
93* fatty acid catabolic process (GO:0009062)3.60172197
94urate metabolic process (GO:0046415)3.59801184
95negative regulation of protein activation cascade (GO:2000258)3.58366253
96fat-soluble vitamin biosynthetic process (GO:0042362)3.58082647
97diacylglycerol metabolic process (GO:0046339)3.58012999
98carnitine metabolic process (GO:0009437)3.57943804
99low-density lipoprotein particle remodeling (GO:0034374)3.54979940
100cholesterol homeostasis (GO:0042632)3.54644215
101serine family amino acid biosynthetic process (GO:0009070)3.54238966
102exogenous drug catabolic process (GO:0042738)3.52635067
103negative regulation of lipase activity (GO:0060192)3.52425621
104glucuronate metabolic process (GO:0019585)3.51208603
105uronic acid metabolic process (GO:0006063)3.51208603
106positive regulation of lipoprotein lipase activity (GO:0051006)3.50887116
107positive regulation of triglyceride lipase activity (GO:0061365)3.50887116
108sterol homeostasis (GO:0055092)3.50372909
109very-low-density lipoprotein particle assembly (GO:0034379)3.47882514
110fibrinolysis (GO:0042730)3.47756669
111ethanol metabolic process (GO:0006067)3.34605650
112low-density lipoprotein particle clearance (GO:0034383)3.34383164
113regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.32386825
114hormone catabolic process (GO:0042447)3.31372506
115intestinal cholesterol absorption (GO:0030299)3.22793875
116negative regulation of complement activation (GO:0045916)3.19993748
117protein-lipid complex assembly (GO:0065005)3.17267110
118lipoprotein metabolic process (GO:0042157)3.12614964
119fatty acid transmembrane transport (GO:1902001)3.10448554
120plasma lipoprotein particle organization (GO:0071827)3.09159373
121carnitine shuttle (GO:0006853)3.08919493
122NADH metabolic process (GO:0006734)3.05294402
123triglyceride catabolic process (GO:0019433)3.00609312
124alkaloid metabolic process (GO:0009820)2.97508544
125protein-lipid complex subunit organization (GO:0071825)2.93999323
126acute-phase response (GO:0006953)2.93894470
127regulation of sequestering of triglyceride (GO:0010889)2.92914698
128acylglycerol catabolic process (GO:0046464)2.89380411
129neutral lipid catabolic process (GO:0046461)2.89380411
130negative regulation of blood coagulation (GO:0030195)2.86763130
131negative regulation of hemostasis (GO:1900047)2.86763130
132protein activation cascade (GO:0072376)2.84563145
133maintenance of gastrointestinal epithelium (GO:0030277)2.83470237
134fatty acid homeostasis (GO:0055089)2.81529734
135complement activation, classical pathway (GO:0006958)2.78090569
136heme transport (GO:0015886)2.76245470
137positive regulation of hemostasis (GO:1900048)2.75853043
138positive regulation of blood coagulation (GO:0030194)2.75853043
139macroautophagy (GO:0016236)2.75371595
140complement activation (GO:0006956)2.74229489
141drug transport (GO:0015893)2.71898393
142regulation of humoral immune response (GO:0002920)2.69343175
143phenylpropanoid metabolic process (GO:0009698)2.69167550
144carnitine transport (GO:0015879)2.68804770
145amino-acid betaine transport (GO:0015838)2.68804770
146blood coagulation, intrinsic pathway (GO:0007597)2.67580381

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse7.68072500
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.58794435
3* LXR_22158963_ChIP-Seq_LIVER_Mouse6.07644864
4EGR1_23403033_ChIP-Seq_LIVER_Mouse5.87032312
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.63296940
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.89306142
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.18359179
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.90750722
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.24081928
10TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.46284969
11TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.00490711
12* ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.6802356
13CLOCK_20551151_ChIP-Seq_293T_Human1.89811215
14* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.77261162
15* FOXA2_19822575_ChIP-Seq_HepG2_Human1.68785777
16FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.67365503
17GATA1_22025678_ChIP-Seq_K562_Human1.40805843
18TP63_17297297_ChIP-ChIP_HaCaT_Human1.38436556
19* HNF4A_19822575_ChIP-Seq_HepG2_Human1.37929321
20CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.36727005
21SMAD_19615063_ChIP-ChIP_OVARY_Human1.35810171
22THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.35571698
23HTT_18923047_ChIP-ChIP_STHdh_Human1.31023439
24SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.29819733
25TCF4_18268006_ChIP-ChIP_LS174T_Human1.23621643
26NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.23512948
27AHR_22903824_ChIP-Seq_MCF-7_Human1.23338206
28IRF8_27001747_Chip-Seq_BMDM_Mouse1.20210402
29STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.17393031
30ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.14538353
31RARG_19884340_ChIP-ChIP_MEFs_Mouse1.14300127
32CTNNB1_20460455_ChIP-Seq_HCT116_Human1.11564937
33IRF8_21731497_ChIP-ChIP_J774_Mouse1.10234591
34STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.09963507
35* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.09308155
36VDR_24787735_ChIP-Seq_THP-1_Human1.08939431
37CJUN_26792858_Chip-Seq_BT549_Human1.05871661
38ESR2_21235772_ChIP-Seq_MCF-7_Human1.05370925
39TP63_23658742_ChIP-Seq_EP156T_Human1.04966644
40PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.04420751
41CDX2_22108803_ChIP-Seq_LS180_Human1.04078197
42ARNT_22903824_ChIP-Seq_MCF-7_Human1.02155368
43* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.00510281
44TP53_16413492_ChIP-PET_HCT116_Human0.98725196
45SOX9_24532713_ChIP-Seq_HFSC_Mouse0.98481148
46PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.97939756
47CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.97450012
48ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.97428487
49RXRA_24833708_ChIP-Seq_LIVER_Mouse0.97054058
50FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.96180532
51FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.93074849
52* EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.92071478
53ZNF263_19887448_ChIP-Seq_K562_Human0.91014995
54MYB_21317192_ChIP-Seq_ERMYB_Mouse0.90341646
55FOXM1_26456572_ChIP-Seq_MCF-7_Human0.89918185
56ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.89346390
57FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.89208305
58P63_26484246_Chip-Seq_KERATINOCYTES_Human0.89124374
59PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89086067
60STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.88663453
61GATA4_25053715_ChIP-Seq_YYC3_Human0.88245745
62GATA3_24758297_ChIP-Seq_MCF-7_Human0.87734500
63EP300_21415370_ChIP-Seq_HL-1_Mouse0.84976532
64NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.84856548
65NRF2_20460467_ChIP-Seq_MEFs_Mouse0.84856548
66AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.84671063
67SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.83601726
68ESR1_15608294_ChIP-ChIP_MCF-7_Human0.83310747
69SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.83257570
70IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.83113296
71TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.81373422
72ESR1_20079471_ChIP-ChIP_T-47D_Human0.80406010
73Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.79540941
74AUTS2_25519132_ChIP-Seq_293T-REX_Human0.79074689
75POU3F2_20337985_ChIP-ChIP_501MEL_Human0.79052413
76SMAD3_21741376_ChIP-Seq_HESCs_Human0.78969983
77NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.78206924
78OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.77412534
79CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.76724980
80ESR1_21235772_ChIP-Seq_MCF-7_Human0.75721291
81RXR_22108803_ChIP-Seq_LS180_Human0.74260732
82CDX2_20551321_ChIP-Seq_CACO-2_Human0.72733806
83SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.72320873
84PPAR_26484153_Chip-Seq_NCI-H1993_Human0.71889642
85ER_23166858_ChIP-Seq_MCF-7_Human0.71794423
86CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.71223731
87SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.71106506
88SALL4_18804426_ChIP-ChIP_XEN_Mouse0.70458501
89FOXO3_23340844_ChIP-Seq_DLD1_Human0.69501181
90ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.69008184
91LXR_22292898_ChIP-Seq_THP-1_Human0.68470459
92TP53_18474530_ChIP-ChIP_U2OS_Human0.68089811
93NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.66629299
94RAD21_21589869_ChIP-Seq_MESCs_Mouse0.63197824
95EGR1_19032775_ChIP-ChIP_M12_Human0.62028062
96MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.61331781
97NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.60705682
98ERG_21242973_ChIP-ChIP_JURKAT_Human0.60207951
99SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.59850397
100GATA1_19941826_ChIP-Seq_K562_Human0.59734447
101RARA_24833708_ChIP-Seq_LIVER_Mouse0.59678772
102BCAT_22108803_ChIP-Seq_LS180_Human0.59447588
103FOXA1_25552417_ChIP-Seq_VCAP_Human0.59034617
104PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.58370710
105PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.58342773
106FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.57703900
107RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.56699613
108GATA2_19941826_ChIP-Seq_K562_Human0.56291301
109CEBPB_22108803_ChIP-Seq_LS180_Human0.55688978
110BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.55596643
111* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.54940742
112TBX20_22080862_ChIP-Seq_HEART_Mouse0.54062167
113TBX20_22328084_ChIP-Seq_HEART_Mouse0.54062167
114CBP_21632823_ChIP-Seq_H3396_Human0.53586399
115SOX2_20726797_ChIP-Seq_SW620_Human0.53349561
116MYC_19915707_ChIP-ChIP_AK7_Human0.53336054
117KAP1_22055183_ChIP-Seq_ESCs_Mouse0.53092618
118ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.52634458
119TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.50799560
120PIAS1_25552417_ChIP-Seq_VCAP_Human0.49651078
121PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.49327640
122TRIM28_21343339_ChIP-Seq_HEK293_Human0.48832459
123RARB_24833708_ChIP-Seq_LIVER_Mouse0.47978948
124SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.47876680
125SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.47645890
126IRF8_22096565_ChIP-ChIP_GC-B_Human0.46813101
127GATA1_19941827_ChIP-Seq_MEL_Mouse0.46577796
128ESET_19884257_ChIP-Seq_ESCs_Mouse0.46568629
129TAF15_26573619_Chip-Seq_HEK293_Human0.46458468
130CDX2_19796622_ChIP-Seq_MESCs_Mouse0.46202517
131GATA6_25053715_ChIP-Seq_YYC3_Human0.45685443
132AR_20517297_ChIP-Seq_VCAP_Human0.45622935
133TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.45580834
134GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.44908834
135TAF2_19829295_ChIP-Seq_ESCs_Human0.43044221
136STAT1_17558387_ChIP-Seq_HELA_Human0.42745523
137GATA2_21666600_ChIP-Seq_HMVEC_Human0.42731369
138GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.42609385
139AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.42601545
140P53_21459846_ChIP-Seq_SAOS-2_Human0.42597011
141ZNF217_24962896_ChIP-Seq_MCF-7_Human0.42582033

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.99002733
2MP0005360_urolithiasis7.34694328
3MP0005085_abnormal_gallbladder_physiolo6.07162010
4MP0005365_abnormal_bile_salt5.94025727
5MP0008875_abnormal_xenobiotic_pharmacok4.91461559
6MP0003252_abnormal_bile_duct3.85706742
7MP0003806_abnormal_nucleotide_metabolis3.79700593
8MP0010329_abnormal_lipoprotein_level3.61730794
9MP0009840_abnormal_foam_cell3.00331684
10MP0003183_abnormal_peptide_metabolism2.98658769
11MP0005332_abnormal_amino_acid2.92791110
12MP0005083_abnormal_biliary_tract2.81460362
13MP0003195_calcinosis2.77117365
14MP0001666_abnormal_nutrient_absorption2.61805501
15MP0003191_abnormal_cellular_cholesterol2.33792270
16MP0004019_abnormal_vitamin_homeostasis2.28144564
17* MP0002118_abnormal_lipid_homeostasis2.22714169
18* MP0000609_abnormal_liver_physiology2.09227481
19MP0002138_abnormal_hepatobiliary_system1.90919296
20MP0005319_abnormal_enzyme/_coenzyme1.82366320
21MP0003868_abnormal_feces_composition1.72032286
22MP0005584_abnormal_enzyme/coenzyme_acti1.66420307
23MP0004264_abnormal_extraembryonic_tissu1.62154227
24MP0001764_abnormal_homeostasis1.53803066
25MP0005670_abnormal_white_adipose1.51273704
26MP0009643_abnormal_urine_homeostasis1.44911635
27MP0005451_abnormal_body_composition1.40880833
28MP0004130_abnormal_muscle_cell1.35210846
29MP0005409_darkened_coat_color1.35042966
30MP0003705_abnormal_hypodermis_morpholog1.25515963
31MP0003011_delayed_dark_adaptation1.23014351
32MP0003186_abnormal_redox_activity1.21642961
33MP0009697_abnormal_copulation1.20280120
34MP0000604_amyloidosis1.10583897
35MP0003656_abnormal_erythrocyte_physiolo1.07496041
36MP0010155_abnormal_intestine_physiology1.07133813
37MP0002254_reproductive_system_inflammat1.06663413
38* MP0000598_abnormal_liver_morphology1.05830613
39MP0002971_abnormal_brown_adipose1.04473980
40MP0005647_abnormal_sex_gland1.03873827
41MP0002876_abnormal_thyroid_physiology1.03143003
42MP0005636_abnormal_mineral_homeostasis1.02960039
43MP0002837_dystrophic_cardiac_calcinosis1.01547343
44MP0010352_gastrointestinal_tract_polyps0.99274275
45MP0005666_abnormal_adipose_tissue0.97966631
46MP0009764_decreased_sensitivity_to0.97854337
47MP0005535_abnormal_body_temperature0.97009311
48MP0006036_abnormal_mitochondrial_physio0.95824318
49MP0002078_abnormal_glucose_homeostasis0.94197583
50MP0005164_abnormal_response_to0.93255174
51MP0003690_abnormal_glial_cell0.92769256
52MP0005334_abnormal_fat_pad0.90694599
53MP0003879_abnormal_hair_cell0.90565443
54MP0009785_altered_susceptibility_to0.90046068
55MP0002909_abnormal_adrenal_gland0.89803525
56MP0009763_increased_sensitivity_to0.89345858
57MP0001756_abnormal_urination0.87013938
58MP0010368_abnormal_lymphatic_system0.86623003
59* MP0009642_abnormal_blood_homeostasis0.86228034
60MP0003866_abnormal_defecation0.85203846
61MP0005084_abnormal_gallbladder_morpholo0.85128149
62MP0004883_abnormal_blood_vessel0.84746884
63MP0003329_amyloid_beta_deposits0.83329594
64MP0002132_abnormal_respiratory_system0.79286267
65MP0001661_extended_life_span0.77562549
66MP0004043_abnormal_pH_regulation0.77199026
67MP0008469_abnormal_protein_level0.76720359
68MP0000569_abnormal_digit_pigmentation0.75652758
69MP0005376_homeostasis/metabolism_phenot0.75056730
70MP0003303_peritoneal_inflammation0.74659966
71MP0003436_decreased_susceptibility_to0.73677739
72MP0003828_pulmonary_edema0.73649622
73MP0006138_congestive_heart_failure0.73196226
74MP0005448_abnormal_energy_balance0.71743064
75MP0002166_altered_tumor_susceptibility0.70648899
76MP0009765_abnormal_xenobiotic_induced0.68948980
77MP0000465_gastrointestinal_hemorrhage0.68179327
78MP0003045_fibrosis0.68031757
79MP0001664_abnormal_digestion0.66595898
80MP0005266_abnormal_metabolism0.66145447
81MP0002822_catalepsy0.65975671
82MP0002136_abnormal_kidney_physiology0.62920564
83MP0004484_altered_response_of0.62855808
84MP0010678_abnormal_skin_adnexa0.62293565
85MP0005220_abnormal_exocrine_pancreas0.62215605
86MP0001845_abnormal_inflammatory_respons0.61612835
87MP0006035_abnormal_mitochondrial_morpho0.61280980
88MP0005408_hypopigmentation0.60872722
89MP0002419_abnormal_innate_immunity0.60318926
90MP0001533_abnormal_skeleton_physiology0.59245465
91MP0000003_abnormal_adipose_tissue0.57807974
92MP0000230_abnormal_systemic_arterial0.55546963
93MP0009115_abnormal_fat_cell0.54442552
94MP0005025_abnormal_response_to0.54299667
95MP0003453_abnormal_keratinocyte_physiol0.53479706
96MP0003953_abnormal_hormone_level0.53092309
97MP0000371_diluted_coat_color0.52695902
98MP0004147_increased_porphyrin_level0.51625771
99MP0005375_adipose_tissue_phenotype0.51063217
100MP0004185_abnormal_adipocyte_glucose0.50552438
101MP0008874_decreased_physiological_sensi0.50368370
102MP0003075_altered_response_to0.50219898
103MP0000639_abnormal_adrenal_gland0.49147839
104MP0001765_abnormal_ion_homeostasis0.47726024
105MP0003638_abnormal_response/metabolism_0.47486610
106MP0010234_abnormal_vibrissa_follicle0.47011930
107MP0002928_abnormal_bile_duct0.46324461
108MP0002796_impaired_skin_barrier0.45659662
109MP0002970_abnormal_white_adipose0.45306942
110MP0002168_other_aberrant_phenotype0.43561412
111MP0005167_abnormal_blood-brain_barrier0.43514274
112MP0005058_abnormal_lysosome_morphology0.43460065
113MP0003724_increased_susceptibility_to0.43406212
114MP0009384_cardiac_valve_regurgitation0.43325855
115MP0008872_abnormal_physiological_respon0.41312852
116MP0005395_other_phenotype0.40517143
117MP0005166_decreased_susceptibility_to0.40462654
118MP0009053_abnormal_anal_canal0.37704688
119MP0003959_abnormal_lean_body0.36306911
120MP0005464_abnormal_platelet_physiology0.35410411
121MP0002090_abnormal_vision0.35398997
122MP0009780_abnormal_chondrocyte_physiolo0.35247838
123MP0003300_gastrointestinal_ulcer0.35026044
124MP0008873_increased_physiological_sensi0.34932373
125MP0008961_abnormal_basal_metabolism0.34031604
126MP0005248_abnormal_Harderian_gland0.33356759
127MP0001881_abnormal_mammary_gland0.33155900
128MP0005330_cardiomyopathy0.32789504
129MP0004782_abnormal_surfactant_physiolog0.31997002
130MP0000249_abnormal_blood_vessel0.30933812
131MP0009672_abnormal_birth_weight0.29824906

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.69623489
2Intrahepatic cholestasis (HP:0001406)6.61524273
3Deep venous thrombosis (HP:0002625)6.54475375
4Xanthomatosis (HP:0000991)6.07086659
5Abnormality of monocarboxylic acid metabolism (HP:0010996)5.95575710
6Hypobetalipoproteinemia (HP:0003563)5.72722600
7Prolonged partial thromboplastin time (HP:0003645)5.57998387
8Hyperlipoproteinemia (HP:0010980)5.17819641
9Complement deficiency (HP:0004431)4.86319315
10Hyperammonemia (HP:0001987)4.67830132
11Ketosis (HP:0001946)4.54001086
12Hyperglycinuria (HP:0003108)4.53123163
13Epidermoid cyst (HP:0200040)4.47602696
14Hypolipoproteinemia (HP:0010981)4.47190742
15Hyperglycinemia (HP:0002154)4.44142572
16Abnormality of glutamine family amino acid metabolism (HP:0010902)4.39514724
17Abnormality of glycine metabolism (HP:0010895)4.35321488
18Abnormality of serine family amino acid metabolism (HP:0010894)4.35321488
19Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.12916781
20Hypoglycemic coma (HP:0001325)4.11456575
21Joint hemorrhage (HP:0005261)4.08969006
22Hypoalphalipoproteinemia (HP:0003233)4.07553816
23Abnormality of the common coagulation pathway (HP:0010990)3.99900988
24Abnormality of aspartate family amino acid metabolism (HP:0010899)3.96016304
25Abnormality of sulfur amino acid metabolism (HP:0004339)3.93417038
26Fat malabsorption (HP:0002630)3.76600699
27Abnormality of fatty-acid metabolism (HP:0004359)3.75228007
28Abnormality of methionine metabolism (HP:0010901)3.68522247
29Ketoacidosis (HP:0001993)3.62429489
30Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.56211901
31Conjugated hyperbilirubinemia (HP:0002908)3.48544152
32Abnormality of complement system (HP:0005339)3.46973103
33Hypercholesterolemia (HP:0003124)3.43851755
34Eczematoid dermatitis (HP:0000976)3.39413163
35Recurrent gram-negative bacterial infections (HP:0005420)3.36156751
36Abnormality of the intrinsic pathway (HP:0010989)3.33706725
37Hyperbilirubinemia (HP:0002904)3.11276680
38Abnormality of pyrimidine metabolism (HP:0004353)3.08724905
39Delayed CNS myelination (HP:0002188)3.08095797
40Abnormality of nucleobase metabolism (HP:0010932)3.04898339
41Abnormality of purine metabolism (HP:0004352)3.02985056
42Gout (HP:0001997)3.02697055
43Abnormality of serum amino acid levels (HP:0003112)2.98514484
44Metabolic acidosis (HP:0001942)2.90805411
45Skin nodule (HP:0200036)2.89667522
46Nephritis (HP:0000123)2.88589205
47Dicarboxylic aciduria (HP:0003215)2.85657969
48Abnormality of dicarboxylic acid metabolism (HP:0010995)2.85657969
49Myocardial infarction (HP:0001658)2.84278615
50Right ventricular cardiomyopathy (HP:0011663)2.83141518
51Hepatocellular carcinoma (HP:0001402)2.77382701
52Spontaneous abortion (HP:0005268)2.72009043
53Steatorrhea (HP:0002570)2.70129580
54Lethargy (HP:0001254)2.65567732
55Vascular calcification (HP:0004934)2.58802431
56Hypoglycemic seizures (HP:0002173)2.56452463
57Facial shape deformation (HP:0011334)2.54593523
58Potter facies (HP:0002009)2.54593523
59Orchitis (HP:0100796)2.48811798
60Systemic lupus erythematosus (HP:0002725)2.46336873
61Generalized aminoaciduria (HP:0002909)2.43401267
62Acanthocytosis (HP:0001927)2.42561200
63Abnormal gallbladder morphology (HP:0012437)2.41970583
64Malnutrition (HP:0004395)2.40731441
65Pigmentary retinal degeneration (HP:0001146)2.40465160
66Abnormality of proline metabolism (HP:0010907)2.40071241
67Hydroxyprolinuria (HP:0003080)2.40071241
68Spastic diplegia (HP:0001264)2.38943574
69Cholelithiasis (HP:0001081)2.38295601
70Sensorimotor neuropathy (HP:0007141)2.37413266
71Cerebral edema (HP:0002181)2.36603633
72Widely patent fontanelles and sutures (HP:0004492)2.35469612
73Cardiovascular calcification (HP:0011915)2.32303778
74Abnormality of vitamin metabolism (HP:0100508)2.31163254
75Neonatal onset (HP:0003623)2.31033756
76Mitral stenosis (HP:0001718)2.28954525
77Cholecystitis (HP:0001082)2.28088129
78Abnormal gallbladder physiology (HP:0012438)2.28088129
79Hypochromic microcytic anemia (HP:0004840)2.27667711
80Vomiting (HP:0002013)2.24669002
81Late onset (HP:0003584)2.23948878
82Amyloidosis (HP:0011034)2.22608082
83Pancreatitis (HP:0001733)2.20401049
84Proximal tubulopathy (HP:0000114)2.20036205
85Hyperuricemia (HP:0002149)2.17708715
86Increased purine levels (HP:0004368)2.17708715
87Flat acetabular roof (HP:0003180)2.17448041
88Optic neuritis (HP:0100653)2.16600501
89Retrobulbar optic neuritis (HP:0100654)2.16600501
90Hyperinsulinemic hypoglycemia (HP:0000825)2.15635834
91Brushfield spots (HP:0001088)2.14710032
92* Irritability (HP:0000737)2.14357058
93Alkalosis (HP:0001948)2.12546794
94Esophageal varix (HP:0002040)2.09939766
95Gingivitis (HP:0000230)2.08802246
96Glomerulonephritis (HP:0000099)2.07844298
97Hemorrhage of the eye (HP:0011885)2.07599508
98Enlarged kidneys (HP:0000105)2.06723930
99Rickets (HP:0002748)2.02224548
100Osteomalacia (HP:0002749)2.00001436
101Abnormal cartilage morphology (HP:0002763)1.99290810
102Glycosuria (HP:0003076)1.96154136
103Abnormality of urine glucose concentration (HP:0011016)1.96154136
104Abnormality of the gallbladder (HP:0005264)1.96022050
105Fair hair (HP:0002286)1.95079913
106Myositis (HP:0100614)1.93358959
107Hyperglycemia (HP:0003074)1.85943268
108Hypertriglyceridemia (HP:0002155)1.85514101
109Renal cortical cysts (HP:0000803)1.84276391
110Peritonitis (HP:0002586)1.84196410
111Thrombophlebitis (HP:0004418)1.83473919
112Myoglobinuria (HP:0002913)1.83248954
113Gingival bleeding (HP:0000225)1.83235651
114Opisthotonus (HP:0002179)1.83227185
115Pulmonary embolism (HP:0002204)1.83026929
116Papillary thyroid carcinoma (HP:0002895)1.82080698
117Poikilocytosis (HP:0004447)1.80600106
118Abnormal enzyme/coenzyme activity (HP:0012379)1.79558855
119Menorrhagia (HP:0000132)1.79474787
120Gastrointestinal infarctions (HP:0005244)1.78624234
121Status epilepticus (HP:0002133)1.78474777
122Hyperactive renin-angiotensin system (HP:0000841)1.78152740
123Mucopolysacchariduria (HP:0008155)1.76704652
124Urinary glycosaminoglycan excretion (HP:0003541)1.76704652
125Chronic diarrhea (HP:0002028)1.76242509
126Hypophosphatemia (HP:0002148)1.75704807
127Vacuolated lymphocytes (HP:0001922)1.70791149
128Abdominal distention (HP:0003270)1.70419247
129Abnormality of macrophages (HP:0004311)1.68880501
130Abnormality of polysaccharide metabolism (HP:0011012)1.68498212
131Abnormality of glycosaminoglycan metabolism (HP:0004371)1.68498212
132Abnormality of mucopolysaccharide metabolism (HP:0011020)1.68498212
133Renal tubular acidosis (HP:0001947)1.68364344
134Keratoconjunctivitis sicca (HP:0001097)1.65920465
135Decreased circulating renin level (HP:0003351)1.65844195
136Abnormal tarsal ossification (HP:0008369)1.65365379
137Nausea (HP:0002018)1.63879464
138Hypophosphatemic rickets (HP:0004912)1.63019397
139Purpura (HP:0000979)1.62057965
140Abnormality of glycosphingolipid metabolism (HP:0004343)1.60636910
141Abnormality of glycolipid metabolism (HP:0010969)1.60636910

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.30145043
2SIK14.22369659
3ERN13.75927842
4FGFR43.66459430
5ACVR1B3.10693013
6INSRR2.84021243
7TRIB32.63975406
8ERBB42.49865068
9MST1R2.24563125
10PKN22.22480269
11TAOK32.19310528
12MAP2K42.16514616
13STK392.07648428
14AKT31.80966267
15FRK1.72780086
16BLK1.70173014
17DAPK21.58594945
18MAPK111.57274657
19LATS11.50161725
20CAMKK21.47538949
21NLK1.47484119
22EPHA21.47070003
23PTK61.44756935
24CAMK1D1.44397431
25FGFR21.43817080
26PIK3CG1.41609482
27MAP3K71.37524216
28PINK11.37048901
29PRKAA21.36718764
30MAP3K121.35525617
31FLT31.33654005
32TAOK11.29790192
33PDK31.29524824
34PDK41.29524824
35RIPK11.23789228
36YES11.23771248
37WNK41.17865467
38ABL21.17776732
39JAK21.12357709
40NEK91.10381626
41MAP3K61.08719703
42PRKG21.03056865
43TYK21.02490544
44CAMK1G1.00788836
45EPHB10.99492757
46TIE10.99382582
47MAPKAPK30.98806478
48OBSCN0.97788216
49JAK10.96570780
50ZAP700.96170620
51SGK30.95625625
52EPHA40.94212374
53STK240.90335959
54PRKAA10.90066130
55ERBB20.89697812
56TRPM70.88252686
57MET0.87833646
58KDR0.85683780
59PDPK10.85596447
60LMTK20.85282882
61STK38L0.85087346
62PRKCZ0.84091964
63IRAK10.83420460
64MAP2K30.80680481
65OXSR10.80678451
66MAPK120.80195698
67PRKACG0.78888782
68MAP3K50.78167410
69SGK4940.78155669
70SGK2230.78155669
71WNK30.75788914
72RIPK40.73639562
73PDK20.73449098
74MAPK40.71919635
75GRK60.71665727
76GSK3A0.71203483
77WNK10.71147180
78SGK20.70861146
79RET0.69145243
80CAMK2G0.68365052
81SCYL20.67489398
82TBK10.67113414
83MAP3K30.66631249
84MAPK150.66004199
85FGFR30.65664849
86EEF2K0.63811355
87PTK20.63603231
88PIK3CA0.61114962
89MAP3K20.61082864
90TGFBR20.60885898
91EPHA30.60665933
92PDK10.60472778
93MAP2K10.60158708
94PDGFRB0.59825467
95PAK30.58777132
96HCK0.57263849
97CDK60.57062852
98MAP3K100.56876893
99PDGFRA0.55815302
100PHKG20.55362057
101PHKG10.55362057
102FGR0.55072190
103MYLK0.55009704
104KSR20.54986009
105DYRK1B0.54897005
106MAP2K60.54599869
107PRPF4B0.52840902
108RPS6KB10.52066386
109MARK20.50435364
110STK380.49480294
111CSK0.48795938
112IRAK40.48216402
113MATK0.47812565
114ICK0.47377593
115STK110.46734612
116MAP3K130.46432248
117NEK60.45749785
118FER0.44686170
119SGK10.43061828
120NTRK30.42938671
121IGF1R0.42493191
122DDR20.41603865
123PRKCH0.41207889
124NEK10.40737318
125MAP3K140.40706993
126PKN10.39746428
127MAPK70.39566987
128IRAK30.39109556
129PRKCQ0.38608405
130MAP3K10.37525529
131NTRK10.37283261
132LATS20.37237702
133CAMKK10.37057856
134MTOR0.35485101
135MAP3K110.34364081
136MAP3K40.33041271

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.12546001
2Nitrogen metabolism_Homo sapiens_hsa009103.60974273
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.21038083
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.19674918
5Arginine biosynthesis_Homo sapiens_hsa002202.90138514
6Tryptophan metabolism_Homo sapiens_hsa003802.68674327
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.68396603
8* Fatty acid degradation_Homo sapiens_hsa000712.67896214
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.66743578
10* Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.50944764
11Butanoate metabolism_Homo sapiens_hsa006502.42443425
12Complement and coagulation cascades_Homo sapiens_hsa046102.39548535
13Propanoate metabolism_Homo sapiens_hsa006402.35021472
14Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.33421312
15Pentose and glucuronate interconversions_Homo sapiens_hsa000402.18079626
16* Peroxisome_Homo sapiens_hsa041462.10877354
17* PPAR signaling pathway_Homo sapiens_hsa033202.07946019
18* Fatty acid metabolism_Homo sapiens_hsa012122.03289565
19Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.95859029
202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.83963684
21beta-Alanine metabolism_Homo sapiens_hsa004101.82957768
22Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.81134070
23Histidine metabolism_Homo sapiens_hsa003401.79525739
24Chemical carcinogenesis_Homo sapiens_hsa052041.74565979
25Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.71789123
26Steroid hormone biosynthesis_Homo sapiens_hsa001401.66154066
27Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.64950466
28Caffeine metabolism_Homo sapiens_hsa002321.62667068
29Pyruvate metabolism_Homo sapiens_hsa006201.60230394
30Bile secretion_Homo sapiens_hsa049761.58856015
31Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.55402825
32Retinol metabolism_Homo sapiens_hsa008301.51878778
33Phenylalanine metabolism_Homo sapiens_hsa003601.50076294
34Drug metabolism - other enzymes_Homo sapiens_hsa009831.49508424
35Staphylococcus aureus infection_Homo sapiens_hsa051501.47841127
36Fatty acid elongation_Homo sapiens_hsa000621.43680040
37Sulfur metabolism_Homo sapiens_hsa009201.41848784
38Selenocompound metabolism_Homo sapiens_hsa004501.37082299
39Starch and sucrose metabolism_Homo sapiens_hsa005001.34537282
40Tyrosine metabolism_Homo sapiens_hsa003501.33899672
41Carbon metabolism_Homo sapiens_hsa012001.29888966
42Fat digestion and absorption_Homo sapiens_hsa049751.26945899
43Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.25481652
44Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.22811274
45ABC transporters_Homo sapiens_hsa020101.20628201
46Biosynthesis of amino acids_Homo sapiens_hsa012301.16207429
47Cysteine and methionine metabolism_Homo sapiens_hsa002701.15069339
48Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.08952750
49Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.05428916
50Folate biosynthesis_Homo sapiens_hsa007901.03255180
51Steroid biosynthesis_Homo sapiens_hsa001001.01205594
52Cyanoamino acid metabolism_Homo sapiens_hsa004600.98482356
53Arginine and proline metabolism_Homo sapiens_hsa003300.93817562
54Maturity onset diabetes of the young_Homo sapiens_hsa049500.92608864
55Vitamin digestion and absorption_Homo sapiens_hsa049770.91879934
56Glycerolipid metabolism_Homo sapiens_hsa005610.90351072
57Fatty acid biosynthesis_Homo sapiens_hsa000610.88279112
58Lysine degradation_Homo sapiens_hsa003100.87362059
59Vitamin B6 metabolism_Homo sapiens_hsa007500.83904093
60Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.79051222
61Sulfur relay system_Homo sapiens_hsa041220.77564432
62Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.76892031
63Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.76084040
64Other glycan degradation_Homo sapiens_hsa005110.67146081
65Glutathione metabolism_Homo sapiens_hsa004800.63544729
66Pentose phosphate pathway_Homo sapiens_hsa000300.54615663
67Sphingolipid metabolism_Homo sapiens_hsa006000.50975916
68Pancreatic secretion_Homo sapiens_hsa049720.45258063
69Pertussis_Homo sapiens_hsa051330.44230573
70Ether lipid metabolism_Homo sapiens_hsa005650.44007537
71* Metabolic pathways_Homo sapiens_hsa011000.43008896
72Adipocytokine signaling pathway_Homo sapiens_hsa049200.42527372
73Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.41425829
74Insulin resistance_Homo sapiens_hsa049310.37602052
75One carbon pool by folate_Homo sapiens_hsa006700.34351226
76Fructose and mannose metabolism_Homo sapiens_hsa000510.33393305
77Galactose metabolism_Homo sapiens_hsa000520.31925571
78Renin secretion_Homo sapiens_hsa049240.29271929
79Prion diseases_Homo sapiens_hsa050200.28010352
80Glucagon signaling pathway_Homo sapiens_hsa049220.23943602
81Glycerophospholipid metabolism_Homo sapiens_hsa005640.23502302
82Prolactin signaling pathway_Homo sapiens_hsa049170.19826652
83AMPK signaling pathway_Homo sapiens_hsa041520.19507863
84Amoebiasis_Homo sapiens_hsa051460.19066935
85Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.18781976
86Leukocyte transendothelial migration_Homo sapiens_hsa046700.18414458
87Lysosome_Homo sapiens_hsa041420.18284927
88Osteoclast differentiation_Homo sapiens_hsa043800.17134142
89Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.15137730
90Tuberculosis_Homo sapiens_hsa051520.14203572
91Platelet activation_Homo sapiens_hsa046110.13341745
92Leishmaniasis_Homo sapiens_hsa051400.12920641
93Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.12806159
94FoxO signaling pathway_Homo sapiens_hsa040680.12410883
95Linoleic acid metabolism_Homo sapiens_hsa005910.11966307
96Circadian rhythm_Homo sapiens_hsa047100.11782596
97Insulin signaling pathway_Homo sapiens_hsa049100.03727260
98Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.01605801
99Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1792606
100Hepatitis C_Homo sapiens_hsa05160-0.1746506
101Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1729732
102Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.1685369
103Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960-0.1660562
104Regulation of autophagy_Homo sapiens_hsa04140-0.1580171
105Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.1345625
106Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1286487
107Protein digestion and absorption_Homo sapiens_hsa04974-0.1235085
108Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.1217479
109Type II diabetes mellitus_Homo sapiens_hsa04930-0.1090380
110Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923-0.1047676
111Mineral absorption_Homo sapiens_hsa04978-0.1017347
112Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0863052
113Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.0809785
114Renin-angiotensin system_Homo sapiens_hsa04614-0.0620250
115Thyroid hormone synthesis_Homo sapiens_hsa04918-0.0569473
116Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0308643
117Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0277984
118* alpha-Linolenic acid metabolism_Homo sapiens_hsa00592-0.0227455

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