ACOX2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The product of this gene belongs to the acyl-CoA oxidase family. It encodes the branched-chain acyl-CoA oxidase which is involved in the degradation of long branched fatty acids and bile acid intermediates in peroxisomes. Deficiency of this enzyme results in the accumulation of branched fatty acids and bile acid intermediates, and may lead to Zellweger syndrome, severe mental retardation, and death in children. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1exogenous drug catabolic process (GO:0042738)7.82228750
2epoxygenase P450 pathway (GO:0019373)7.78755583
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.54717971
4L-phenylalanine catabolic process (GO:0006559)7.54717971
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.23512874
6L-phenylalanine metabolic process (GO:0006558)7.23512874
7omega-hydroxylase P450 pathway (GO:0097267)7.20067161
8aromatic amino acid family catabolic process (GO:0009074)6.91786293
9indole-containing compound catabolic process (GO:0042436)6.36248557
10indolalkylamine catabolic process (GO:0046218)6.36248557
11tryptophan catabolic process (GO:0006569)6.36248557
12kynurenine metabolic process (GO:0070189)6.19145628
13triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.14950326
14tryptophan metabolic process (GO:0006568)5.97960339
15glyoxylate metabolic process (GO:0046487)5.96196977
16* bile acid biosynthetic process (GO:0006699)5.77004847
17urea cycle (GO:0000050)5.65179477
18urea metabolic process (GO:0019627)5.65179477
19cysteine metabolic process (GO:0006534)5.54134002
20negative regulation of fibrinolysis (GO:0051918)5.53337874
21alpha-linolenic acid metabolic process (GO:0036109)5.47353284
22drug metabolic process (GO:0017144)5.44390584
23high-density lipoprotein particle remodeling (GO:0034375)5.42627823
24sulfur amino acid catabolic process (GO:0000098)5.34844496
25regulation of fibrinolysis (GO:0051917)5.33614027
26regulation of protein activation cascade (GO:2000257)5.33508807
27complement activation, alternative pathway (GO:0006957)5.32239115
28peptidyl-glutamic acid carboxylation (GO:0017187)5.25450448
29protein carboxylation (GO:0018214)5.25450448
30nitrogen cycle metabolic process (GO:0071941)5.20077968
31serine family amino acid catabolic process (GO:0009071)5.18120561
32ethanol metabolic process (GO:0006067)5.17352919
33regulation of plasminogen activation (GO:0010755)5.04969740
34aromatic amino acid family metabolic process (GO:0009072)5.03078306
35regulation of complement activation (GO:0030449)4.99035418
36lysine catabolic process (GO:0006554)4.94410334
37lysine metabolic process (GO:0006553)4.94410334
38homocysteine metabolic process (GO:0050667)4.91448595
39* bile acid metabolic process (GO:0008206)4.89891131
40oxidative demethylation (GO:0070989)4.80333783
41reverse cholesterol transport (GO:0043691)4.79326650
42regulation of triglyceride catabolic process (GO:0010896)4.78130673
43tyrosine metabolic process (GO:0006570)4.75974573
44regulation of cholesterol esterification (GO:0010872)4.73145031
45amino-acid betaine metabolic process (GO:0006577)4.71857736
46alpha-amino acid catabolic process (GO:1901606)4.68998249
47protein-lipid complex remodeling (GO:0034368)4.68296226
48macromolecular complex remodeling (GO:0034367)4.68296226
49plasma lipoprotein particle remodeling (GO:0034369)4.68296226
50negative regulation of blood coagulation (GO:0030195)4.63558044
51negative regulation of hemostasis (GO:1900047)4.63558044
52positive regulation of heterotypic cell-cell adhesion (GO:0034116)4.54654953
53acylglycerol homeostasis (GO:0055090)4.54086977
54triglyceride homeostasis (GO:0070328)4.54086977
55* fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.53363965
56cellular ketone body metabolic process (GO:0046950)4.51434119
57indolalkylamine metabolic process (GO:0006586)4.50732375
58phospholipid efflux (GO:0033700)4.48065575
59negative regulation of sterol transport (GO:0032372)4.47508151
60negative regulation of cholesterol transport (GO:0032375)4.47508151
61cellular biogenic amine catabolic process (GO:0042402)4.40715320
62amine catabolic process (GO:0009310)4.40715320
63glycine metabolic process (GO:0006544)4.38529226
64phenylpropanoid metabolic process (GO:0009698)4.37328311
65coenzyme catabolic process (GO:0009109)4.35488112
66cellular amino acid catabolic process (GO:0009063)4.33438720
67glutamate metabolic process (GO:0006536)4.32538160
68bile acid and bile salt transport (GO:0015721)4.32125351
69plasma lipoprotein particle clearance (GO:0034381)4.30970809
70negative regulation of coagulation (GO:0050819)4.30549317
71negative regulation of protein activation cascade (GO:2000258)4.30042247
72serine family amino acid metabolic process (GO:0009069)4.29315713
73intestinal cholesterol absorption (GO:0030299)4.27404874
74imidazole-containing compound metabolic process (GO:0052803)4.23103453
75benzene-containing compound metabolic process (GO:0042537)4.19340279
76cellular glucuronidation (GO:0052695)4.19041322
77cellular modified amino acid catabolic process (GO:0042219)4.15699859
78cholesterol efflux (GO:0033344)4.13863995
79negative regulation of wound healing (GO:0061045)4.10609575
80ethanol oxidation (GO:0006069)4.10461443
81serine family amino acid biosynthetic process (GO:0009070)4.09116709
82dicarboxylic acid biosynthetic process (GO:0043650)4.06147578
83aldehyde catabolic process (GO:0046185)4.03835211
84arginine metabolic process (GO:0006525)4.00421383
85plasma lipoprotein particle organization (GO:0071827)3.99917728
86protein-lipid complex assembly (GO:0065005)3.99400234
87drug catabolic process (GO:0042737)3.99180079
88fibrinolysis (GO:0042730)3.96793669
89plasma lipoprotein particle assembly (GO:0034377)3.93624824
90regulation of humoral immune response (GO:0002920)3.91104159
91ketone body metabolic process (GO:1902224)3.90570087
92low-density lipoprotein particle remodeling (GO:0034374)3.88667874
93acute-phase response (GO:0006953)3.88132843
94fat-soluble vitamin biosynthetic process (GO:0042362)3.81468388
95acetyl-CoA metabolic process (GO:0006084)3.79301489
96protein-lipid complex subunit organization (GO:0071825)3.78926370
97blood coagulation, intrinsic pathway (GO:0007597)3.77089771
98positive regulation of triglyceride lipase activity (GO:0061365)3.76805003
99positive regulation of lipoprotein lipase activity (GO:0051006)3.76805003
100short-chain fatty acid metabolic process (GO:0046459)3.76679689
101* organic acid catabolic process (GO:0016054)3.76353934
102* carboxylic acid catabolic process (GO:0046395)3.76353934
103positive regulation of hemostasis (GO:1900048)3.75116677
104positive regulation of blood coagulation (GO:0030194)3.75116677
105glucuronate metabolic process (GO:0019585)3.74756967
106uronic acid metabolic process (GO:0006063)3.74756967
107phospholipid homeostasis (GO:0055091)3.74484334
108urate metabolic process (GO:0046415)3.72452711
109complement activation, classical pathway (GO:0006958)3.72334192
110cytolysis (GO:0019835)3.71637456
111cofactor catabolic process (GO:0051187)3.71577633
112cholesterol homeostasis (GO:0042632)3.69573240
113very-low-density lipoprotein particle assembly (GO:0034379)3.67737900
114complement activation (GO:0006956)3.67474239
115drug transmembrane transport (GO:0006855)3.67169438
116positive regulation of lipid catabolic process (GO:0050996)3.65963425
117protein activation cascade (GO:0072376)3.65672086
118sterol homeostasis (GO:0055092)3.64242151
119aspartate family amino acid catabolic process (GO:0009068)3.63817808
120negative regulation of lipase activity (GO:0060192)3.62656284
121regulation of cholesterol homeostasis (GO:2000188)3.62291823
122regulation of bile acid biosynthetic process (GO:0070857)3.62178848
123S-adenosylmethionine metabolic process (GO:0046500)3.61767238
124NAD biosynthetic process (GO:0009435)3.56603005
125alkaloid metabolic process (GO:0009820)3.56570382
126flavonoid metabolic process (GO:0009812)3.52923573
127positive regulation of coagulation (GO:0050820)3.49505350
128positive regulation of fatty acid biosynthetic process (GO:0045723)3.46603110
129lipoprotein metabolic process (GO:0042157)3.45748937
130response to mercury ion (GO:0046689)3.44142272
131heme transport (GO:0015886)3.42751264
132opsonization (GO:0008228)3.41381391
133negative regulation of complement activation (GO:0045916)3.40442261
134hormone catabolic process (GO:0042447)3.32933943
135regulation of apoptotic cell clearance (GO:2000425)3.28485115

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.34776874
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse7.16797960
3* EGR1_23403033_ChIP-Seq_LIVER_Mouse6.98790449
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.46950448
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.21055884
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.05961973
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.83214034
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.06824102
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.00414901
10HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.08364760
11TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.08017124
12TRIM28_21343339_ChIP-Seq_HEK293_Human2.03622200
13* ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.8685171
14* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.95191682
15FOXA2_19822575_ChIP-Seq_HepG2_Human1.62728675
16CLOCK_20551151_ChIP-Seq_293T_Human1.56748209
17HTT_18923047_ChIP-ChIP_STHdh_Human1.50219938
18* HNF4A_19822575_ChIP-Seq_HepG2_Human1.43335465
19GATA1_22025678_ChIP-Seq_K562_Human1.40281317
20MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.28809244
21STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.25294617
22THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.21599574
23RXRA_24833708_ChIP-Seq_LIVER_Mouse1.19315714
24STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.09509572
25CDX2_19796622_ChIP-Seq_MESCs_Mouse1.08562775
26TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.04727865
27IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.04477838
28ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.03648849
29ESR1_15608294_ChIP-ChIP_MCF-7_Human1.03080366
30* SOX2_27498859_Chip-Seq_STOMACH_Mouse0.95359667
31PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.93505245
32RARG_19884340_ChIP-ChIP_MEFs_Mouse0.92254832
33PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.91276165
34FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.90686230
35IRF8_22096565_ChIP-ChIP_GC-B_Human0.85428714
36* GATA4_25053715_ChIP-Seq_YYC3_Human0.84483280
37TCF4_18268006_ChIP-ChIP_LS174T_Human0.84340820
38ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.83489483
39AUTS2_25519132_ChIP-Seq_293T-REX_Human0.81872092
40TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.80064706
41KAP1_22055183_ChIP-Seq_ESCs_Mouse0.79345024
42CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.79293826
43EP300_21415370_ChIP-Seq_HL-1_Mouse0.77495510
44ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.76691710
45CJUN_26792858_Chip-Seq_BT549_Human0.76352504
46BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.75722559
47Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.75657024
48SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.75027151
49ESR2_21235772_ChIP-Seq_MCF-7_Human0.74504444
50CSB_26484114_Chip-Seq_FIBROBLAST_Human0.74295983
51SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.72918635
52RARA_24833708_ChIP-Seq_LIVER_Mouse0.72872201
53CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.72527599
54TP53_18474530_ChIP-ChIP_U2OS_Human0.72474632
55PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.71193239
56GATA2_21666600_ChIP-Seq_HMVEC_Human0.71145169
57AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.70370193
58NFIB_24661679_ChIP-Seq_LUNG_Mouse0.70366709
59SALL4_18804426_ChIP-ChIP_XEN_Mouse0.69739944
60SOX2_21211035_ChIP-Seq_LN229_Human0.68548770
61RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.68373257
62NRF2_20460467_ChIP-Seq_MEFs_Mouse0.68247476
63NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.68247476
64ZNF263_19887448_ChIP-Seq_K562_Human0.66062893
65SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.66032400
66NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.64494394
67GATA3_24758297_ChIP-Seq_MCF-7_Human0.63916560
68PIAS1_25552417_ChIP-Seq_VCAP_Human0.63867500
69ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.63826524
70ESR1_21235772_ChIP-Seq_MCF-7_Human0.63541016
71RAD21_21589869_ChIP-Seq_MESCs_Mouse0.63335843
72POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.63052306
73BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.62835837
74RARB_24833708_ChIP-Seq_LIVER_Mouse0.61550236
75EGR1_19032775_ChIP-ChIP_M12_Human0.60373180
76CEBPB_22108803_ChIP-Seq_LS180_Human0.58444704
77EOMES_21245162_ChIP-Seq_HESCs_Human0.57806429
78STAT3_1855785_ChIP-Seq_MESCs_Mouse0.56596010
79TBX20_22328084_ChIP-Seq_HEART_Mouse0.55573969
80TBX20_22080862_ChIP-Seq_HEART_Mouse0.55573969
81AR_20517297_ChIP-Seq_VCAP_Human0.55313010
82FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.54887166
83HIF1A_21447827_ChIP-Seq_MCF-7_Human0.54764369
84SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.54682608
85ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.54575842
86CDX2_20551321_ChIP-Seq_CACO-2_Human0.53809914
87TP53_16413492_ChIP-PET_HCT116_Human0.53401171
88* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.52664888
89LXR_22292898_ChIP-Seq_THP-1_Human0.52020101
90AR_21909140_ChIP-Seq_LNCAP_Human0.51797114
91* BCAT_22108803_ChIP-Seq_LS180_Human0.51785249
92* MYC_19915707_ChIP-ChIP_AK7_Human0.51642042
93* FOXA1_25552417_ChIP-Seq_VCAP_Human0.51433818
94HNFA_21074721_ChIP-Seq_CACO-2_Human0.51043466
95FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.50093355
96STAT1_17558387_ChIP-Seq_HELA_Human0.49574236
97* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.49255037
98ESET_19884257_ChIP-Seq_ESCs_Mouse0.49172824
99CBP_21632823_ChIP-Seq_H3396_Human0.48608003
100PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.47189222
101FOXO3_23340844_ChIP-Seq_DLD1_Human0.45100185
102P53_21459846_ChIP-Seq_SAOS-2_Human0.44945785
103ESR1_20079471_ChIP-ChIP_T-47D_Human0.44847514
104FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.44176981
105TAF2_19829295_ChIP-Seq_ESCs_Human0.43938000
106TAF15_26573619_Chip-Seq_HEK293_Human0.43793364
107PPAR_26484153_Chip-Seq_NCI-H1993_Human0.43711140
108PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.43676943
109GATA6_25053715_ChIP-Seq_YYC3_Human0.43604174
110PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.42471816
111FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.42332905
112GATA1_19941827_ChIP-Seq_MEL_Mouse0.41564438
113NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.41194195
114CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.41168210
115GATA2_19941826_ChIP-Seq_K562_Human0.41038468
116GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.40331548
117GATA1_19941826_ChIP-Seq_K562_Human0.40125390
118E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.38937768
119STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.38914560
120* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.38682846
121SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.37543962
122MYC_27129775_Chip-Seq_CORNEA_Mouse0.37114323
123FOXH1_21741376_ChIP-Seq_EPCs_Human0.36817229
124SOX2_20726797_ChIP-Seq_SW620_Human0.35990605
125CDX2_22108803_ChIP-Seq_LS180_Human0.35980528
126ERG_21242973_ChIP-ChIP_JURKAT_Human0.35879303
127CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.35090381
128ERG_20517297_ChIP-Seq_VCAP_Human0.35037625
129LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.34626821
130NCOR_22424771_ChIP-Seq_293T_Human0.34514107

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.24170944
2MP0005360_urolithiasis7.71448114
3MP0005085_abnormal_gallbladder_physiolo6.34621904
4MP0005365_abnormal_bile_salt6.14217913
5MP0008875_abnormal_xenobiotic_pharmacok5.01604557
6MP0003806_abnormal_nucleotide_metabolis4.24890126
7MP0003252_abnormal_bile_duct3.94350766
8MP0010329_abnormal_lipoprotein_level3.51959585
9MP0009840_abnormal_foam_cell3.13925744
10MP0005083_abnormal_biliary_tract2.94535945
11MP0003195_calcinosis2.94441892
12MP0005332_abnormal_amino_acid2.92987477
13MP0001666_abnormal_nutrient_absorption2.60445560
14MP0003191_abnormal_cellular_cholesterol2.36483444
15MP0004019_abnormal_vitamin_homeostasis2.33308390
16MP0002138_abnormal_hepatobiliary_system2.14510043
17MP0000609_abnormal_liver_physiology2.12564273
18MP0002118_abnormal_lipid_homeostasis2.06438239
19MP0003868_abnormal_feces_composition1.86763372
20MP0005319_abnormal_enzyme/_coenzyme1.83771368
21MP0001764_abnormal_homeostasis1.69777674
22MP0005584_abnormal_enzyme/coenzyme_acti1.58395346
23MP0009697_abnormal_copulation1.53715223
24MP0005451_abnormal_body_composition1.41006149
25MP0009643_abnormal_urine_homeostasis1.40342344
26MP0003011_delayed_dark_adaptation1.35630642
27MP0003186_abnormal_redox_activity1.33155715
28MP0003656_abnormal_erythrocyte_physiolo1.21051385
29MP0000598_abnormal_liver_morphology1.15652287
30MP0004272_abnormal_basement_membrane1.11796665
31MP0005647_abnormal_sex_gland1.11035659
32MP0003705_abnormal_hypodermis_morpholog1.10021391
33MP0005636_abnormal_mineral_homeostasis1.07409138
34MP0009764_decreased_sensitivity_to1.07267491
35MP0000604_amyloidosis1.03577683
36MP0002254_reproductive_system_inflammat0.99792591
37MP0009763_increased_sensitivity_to0.98185964
38MP0010368_abnormal_lymphatic_system0.93475790
39MP0008469_abnormal_protein_level0.89740358
40MP0009642_abnormal_blood_homeostasis0.87883056
41MP0005084_abnormal_gallbladder_morpholo0.86289415
42MP0005408_hypopigmentation0.86276111
43MP0008438_abnormal_cutaneous_collagen0.84109573
44MP0002876_abnormal_thyroid_physiology0.83879611
45MP0006036_abnormal_mitochondrial_physio0.83681230
46MP0001915_intracranial_hemorrhage0.81134445
47MP0005376_homeostasis/metabolism_phenot0.79292092
48MP0002282_abnormal_trachea_morphology0.78810668
49MP0005670_abnormal_white_adipose0.78650895
50MP0009765_abnormal_xenobiotic_induced0.76809669
51MP0002078_abnormal_glucose_homeostasis0.75985384
52MP0005023_abnormal_wound_healing0.75852376
53MP0005220_abnormal_exocrine_pancreas0.74345302
54MP0001756_abnormal_urination0.74152534
55MP0000751_myopathy0.70717652
56MP0005330_cardiomyopathy0.70200195
57MP0005164_abnormal_response_to0.70114912
58MP0005535_abnormal_body_temperature0.69781294
59MP0002971_abnormal_brown_adipose0.67310876
60MP0001661_extended_life_span0.67129961
61MP0005334_abnormal_fat_pad0.65632240
62MP0009053_abnormal_anal_canal0.64474018
63MP0004130_abnormal_muscle_cell0.63499115
64MP0003690_abnormal_glial_cell0.63282726
65MP0003879_abnormal_hair_cell0.62825174
66MP0005266_abnormal_metabolism0.62394939
67MP0003329_amyloid_beta_deposits0.59772464
68MP0002136_abnormal_kidney_physiology0.59575259
69MP0006035_abnormal_mitochondrial_morpho0.58219992
70MP0000639_abnormal_adrenal_gland0.54693289
71MP0009780_abnormal_chondrocyte_physiolo0.54623933
72MP0002928_abnormal_bile_duct0.51839995
73MP0005395_other_phenotype0.51329604
74MP0005448_abnormal_energy_balance0.50131197
75MP0002249_abnormal_larynx_morphology0.50070001
76MP0005464_abnormal_platelet_physiology0.49429471
77MP0003638_abnormal_response/metabolism_0.47600684
78MP0003718_maternal_effect0.47003964
79MP0003724_increased_susceptibility_to0.45872073
80MP0004043_abnormal_pH_regulation0.45257372
81MP0004782_abnormal_surfactant_physiolog0.45157195
82MP0004381_abnormal_hair_follicle0.44731063
83MP0008873_increased_physiological_sensi0.41714112
84MP0008874_decreased_physiological_sensi0.41146177
85MP0003953_abnormal_hormone_level0.40451521
86MP0005166_decreased_susceptibility_to0.39947730
87MP0005257_abnormal_intraocular_pressure0.39925532
88MP0003075_altered_response_to0.39785675
89MP0002822_catalepsy0.39251830
90MP0002796_impaired_skin_barrier0.39052376
91MP0002295_abnormal_pulmonary_circulatio0.38472749
92MP0003436_decreased_susceptibility_to0.38431171
93MP0005666_abnormal_adipose_tissue0.38062354
94MP0005248_abnormal_Harderian_gland0.37942529
95MP0002128_abnormal_blood_circulation0.36787994
96MP0000579_abnormal_nail_morphology0.36463350
97MP0002269_muscular_atrophy0.36369670
98MP0000230_abnormal_systemic_arterial0.35859155
99MP0009384_cardiac_valve_regurgitation0.35381957
100MP0002168_other_aberrant_phenotype0.35021209
101MP0008775_abnormal_heart_ventricle0.34769873
102MP0008872_abnormal_physiological_respon0.34053579
103MP0002837_dystrophic_cardiac_calcinosis0.33875858
104MP0009672_abnormal_birth_weight0.33485816
105MP0001765_abnormal_ion_homeostasis0.32922355
106MP0003941_abnormal_skin_development0.31740135
107MP0005058_abnormal_lysosome_morphology0.31238158
108MP0009115_abnormal_fat_cell0.30825142
109MP0002332_abnormal_exercise_endurance0.30613817
110MP0006082_CNS_inflammation0.30557200
111MP0005197_abnormal_uvea_morphology0.29623202
112MP0000249_abnormal_blood_vessel0.29147028
113MP0005375_adipose_tissue_phenotype0.29044904
114MP0001845_abnormal_inflammatory_respons0.28914741
115MP0005165_increased_susceptibility_to0.28727363
116MP0004883_abnormal_blood_vessel0.28521513
117MP0001243_abnormal_dermal_layer0.27997824
118MP0005187_abnormal_penis_morphology0.27986039
119MP0002135_abnormal_kidney_morphology0.27785644
120MP0002132_abnormal_respiratory_system0.27683344
121MP0004264_abnormal_extraembryonic_tissu0.27265312
122MP0001881_abnormal_mammary_gland0.27055353
123MP0003878_abnormal_ear_physiology0.26630018
124MP0005377_hearing/vestibular/ear_phenot0.26630018
125MP0002089_abnormal_postnatal_growth/wei0.26564725

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.24366985
2Intrahepatic cholestasis (HP:0001406)7.22983748
3Deep venous thrombosis (HP:0002625)7.18640576
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.54639825
5Prolonged partial thromboplastin time (HP:0003645)6.39765949
6Xanthomatosis (HP:0000991)6.21541952
7Hypobetalipoproteinemia (HP:0003563)6.19077674
8Complement deficiency (HP:0004431)5.42292222
9Hyperlipoproteinemia (HP:0010980)5.31210708
10Joint hemorrhage (HP:0005261)4.76281742
11Hypolipoproteinemia (HP:0010981)4.65647505
12Hyperammonemia (HP:0001987)4.64488794
13Hyperglycinemia (HP:0002154)4.53074463
14Abnormality of glutamine family amino acid metabolism (HP:0010902)4.42628014
15Epidermoid cyst (HP:0200040)4.40755980
16Abnormality of the common coagulation pathway (HP:0010990)4.38061195
17Ketosis (HP:0001946)4.34114497
18Abnormality of sulfur amino acid metabolism (HP:0004339)4.28353231
19Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.25984257
20Hyperglycinuria (HP:0003108)4.23115331
21Abnormality of aspartate family amino acid metabolism (HP:0010899)4.21865320
22Abnormality of methionine metabolism (HP:0010901)4.14912763
23Fat malabsorption (HP:0002630)4.14046070
24Abnormality of glycine metabolism (HP:0010895)4.13705289
25Abnormality of serine family amino acid metabolism (HP:0010894)4.13705289
26Hypoalphalipoproteinemia (HP:0003233)4.06378060
27Abnormality of complement system (HP:0005339)3.94148416
28Hypoglycemic coma (HP:0001325)3.83948798
29Abnormality of pyrimidine metabolism (HP:0004353)3.79937369
30Abnormality of the intrinsic pathway (HP:0010989)3.69267948
31Conjugated hyperbilirubinemia (HP:0002908)3.67299608
32Nephritis (HP:0000123)3.53919224
33Abnormality of fatty-acid metabolism (HP:0004359)3.49390697
34Hypercholesterolemia (HP:0003124)3.46747289
35Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.31066685
36Hyperbilirubinemia (HP:0002904)3.27072412
37Abnormality of nucleobase metabolism (HP:0010932)3.22589451
38Ketoacidosis (HP:0001993)3.21629775
39Delayed CNS myelination (HP:0002188)3.19562947
40Abnormality of serum amino acid levels (HP:0003112)3.13112825
41Steatorrhea (HP:0002570)3.11495777
42Hepatocellular carcinoma (HP:0001402)3.01570041
43Spontaneous abortion (HP:0005268)2.98654672
44Abnormality of purine metabolism (HP:0004352)2.93915493
45Gout (HP:0001997)2.92364367
46Hypochromic microcytic anemia (HP:0004840)2.89160326
47Myocardial infarction (HP:0001658)2.85806307
48Metabolic acidosis (HP:0001942)2.85798525
49Systemic lupus erythematosus (HP:0002725)2.77426384
50Skin nodule (HP:0200036)2.70305622
51Vascular calcification (HP:0004934)2.68256420
52Lethargy (HP:0001254)2.67196917
53Dicarboxylic aciduria (HP:0003215)2.67039125
54Abnormality of dicarboxylic acid metabolism (HP:0010995)2.67039125
55Acanthocytosis (HP:0001927)2.50269393
56Spastic diplegia (HP:0001264)2.47840097
57Hypoglycemic seizures (HP:0002173)2.44058988
58Cerebral edema (HP:0002181)2.43750422
59Recurrent gram-negative bacterial infections (HP:0005420)2.41140373
60Neonatal onset (HP:0003623)2.41125677
61Glomerulonephritis (HP:0000099)2.38995350
62Irritability (HP:0000737)2.38083237
63Cardiovascular calcification (HP:0011915)2.37854732
64Mitral stenosis (HP:0001718)2.37826378
65Malnutrition (HP:0004395)2.36519571
66Abnormal gallbladder morphology (HP:0012437)2.36209742
67Cholelithiasis (HP:0001081)2.31312414
68Osteomalacia (HP:0002749)2.31214318
69Cholecystitis (HP:0001082)2.27246924
70Abnormal gallbladder physiology (HP:0012438)2.27246924
71Purpura (HP:0000979)2.24994131
72Increased serum pyruvate (HP:0003542)2.24881721
73Generalized aminoaciduria (HP:0002909)2.23842589
74Amyloidosis (HP:0011034)2.23311890
75Enlarged kidneys (HP:0000105)2.23239610
76Sensorimotor neuropathy (HP:0007141)2.19519801
77Pancreatitis (HP:0001733)2.17456286
78Vomiting (HP:0002013)2.17389155
79Esophageal varix (HP:0002040)2.17309245
80Reduced antithrombin III activity (HP:0001976)2.16179368
81Alkalosis (HP:0001948)2.14800688
82Gingival bleeding (HP:0000225)2.14796656
83Late onset (HP:0003584)2.11855242
84Abnormality of vitamin metabolism (HP:0100508)2.11791405
85Menorrhagia (HP:0000132)2.08996163
86Rickets (HP:0002748)2.06898630
87Thrombophlebitis (HP:0004418)2.06081540
88Brushfield spots (HP:0001088)2.05604343
89Proximal tubulopathy (HP:0000114)2.04349898
90Increased purine levels (HP:0004368)2.03651979
91Hyperuricemia (HP:0002149)2.03651979
92Abnormal delivery (HP:0001787)2.02658014
93Hydroxyprolinuria (HP:0003080)2.02289178
94Abnormality of proline metabolism (HP:0010907)2.02289178
95Opisthotonus (HP:0002179)2.01573608
96Abnormality of the Achilles tendon (HP:0005109)1.98279366
97Hyperphosphaturia (HP:0003109)1.98062846
98Abnormality of glycolysis (HP:0004366)1.94921239
99Hemorrhage of the eye (HP:0011885)1.94717555
100Hyperinsulinemic hypoglycemia (HP:0000825)1.94436019
101Abnormality of the gallbladder (HP:0005264)1.94116423
102Poikilocytosis (HP:0004447)1.93848732
103Abnormal enzyme/coenzyme activity (HP:0012379)1.91112537
104Renal cortical cysts (HP:0000803)1.89925812
105Hypophosphatemic rickets (HP:0004912)1.88415117
106Abnormal cartilage morphology (HP:0002763)1.87451563
107Abnormality of transition element cation homeostasis (HP:0011030)1.86837940
108Fair hair (HP:0002286)1.86250902
109Abnormality of iron homeostasis (HP:0011031)1.86071449
110Elevated alkaline phosphatase (HP:0003155)1.85685750
111Abnormality of urine glucose concentration (HP:0011016)1.83648868
112Glycosuria (HP:0003076)1.83648868
113Abnormality of alkaline phosphatase activity (HP:0004379)1.81529485
114Joint swelling (HP:0001386)1.81364511
115Arthropathy (HP:0003040)1.69004196
116Abnormal urine phosphate concentration (HP:0012599)1.64180504
117Retinal atrophy (HP:0001105)1.63128654
118Cerebral palsy (HP:0100021)1.58781514
119Nausea (HP:0002018)1.58718203
120Epistaxis (HP:0000421)1.57049142
121Pulmonary embolism (HP:0002204)1.56630052
122Abnormal tarsal ossification (HP:0008369)1.55346522
123Back pain (HP:0003418)1.53991897

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.21763839
2PDK25.33359276
3FGFR44.58209150
4SIK14.36157969
5ERN14.30395730
6ERBB43.05941522
7TAOK33.00942201
8INSRR2.93823712
9MYLK2.91592140
10MST1R2.31806188
11MAP2K42.18162594
12PIK3CA2.18009328
13MAPK111.96984085
14LMTK21.89631920
15EPHA21.85596070
16PKN21.83222837
17LATS11.83082469
18PIK3CG1.80684071
19PDGFRA1.77489578
20AKT31.76911378
21FLT31.67077827
22TYK21.61832621
23MAPKAPK31.55695861
24TRIB31.53199408
25DAPK21.49626163
26NEK91.48935763
27ABL21.48013273
28PTK61.47706831
29FRK1.41061647
30TESK21.40470984
31OBSCN1.30959429
32STK38L1.30239384
33FGFR21.29867032
34ACVR1B1.28169706
35MAP3K71.25159050
36PINK11.23370798
37JAK21.20962897
38KDR1.20577824
39TESK11.18312157
40PRKAA21.13547878
41GRK61.10354676
42ERBB21.08029731
43EIF2AK11.02522796
44DDR21.02457098
45EIF2AK31.02448076
46MAP3K141.00760340
47TBK11.00392299
48MAP2K30.99107653
49JAK10.97248832
50LIMK10.94714265
51FER0.94150317
52WNK30.93926818
53MAPK40.92955800
54MAP3K100.92404783
55MAP3K30.92309204
56PRKCZ0.92003008
57PIM20.91942348
58MAPK150.91738898
59EPHB10.89857770
60EPHA30.89532892
61MET0.87124343
62TIE10.84619045
63IRAK30.82080035
64SGK30.77990523
65PRKACG0.75370133
66CDK60.73598549
67MAP3K110.73023803
68MAPK120.72574538
69GSK3A0.71963413
70CAMK2G0.71472331
71PRKAA10.71161843
72NEK10.70895879
73DYRK1B0.70891046
74STK160.69868145
75MST40.68544331
76MAP3K120.66164706
77PRKG10.65944977
78TGFBR20.65825703
79SGK20.63619969
80PRKG20.63286834
81RIPK10.63255424
82CSK0.62251777
83MAP2K60.61622238
84PTK20.59631409
85FGFR10.56710312
86SGK2230.56465812
87SGK4940.56465812
88PRKACA0.56091238
89CAMK1D0.55012096
90PHKG20.54966014
91PHKG10.54966014
92MAPK70.54202524
93FGFR30.53669850
94IKBKE0.53648714
95PDPK10.52745101
96WNK40.52392327
97SCYL20.51750634
98SRC0.50946485
99AKT20.49924341
100TTN0.49019582
101CAMK2D0.48845439
102CSF1R0.48339436
103PRKD10.48038394
104GRK10.47563022
105MAP3K20.47506359
106PRKCQ0.47278083
107PRKACB0.47054536
108PAK20.45725034
109TRPM70.45253753
110OXSR10.44882551
111PRKCE0.44631985
112CSNK1G10.44587810
113CDK80.43434336
114TAOK20.43430143
115MAP2K10.43199405
116IGF1R0.43128128
117PKN10.43032218
118DAPK30.40878341
119MAP3K50.40615557
120PDK40.40383386
121PDK30.40383386
122BMX0.40287813
123CDC42BPA0.38983657
124PRKCG0.37015495
125GRK70.35218539
126STK380.34271471
127CDK40.34161368
128IRAK10.33482567
129EPHA40.33432171
130CCNB10.33400670
131EGFR0.32811631
132CSNK2A20.32735663
133ICK0.32668382
134PBK0.32583570
135ROCK10.32039903
136PAK40.31640375
137CAMK40.31629283
138MTOR0.31590329
139MAP3K130.30491731
140IRAK20.29735292
141PDK10.29621089
142MAP3K60.29178215
143RET0.28915168
144PAK30.27146179
145PRKCA0.26305027
146MAP3K10.23599406
147MAP2K20.22844105
148LATS20.22101293
149ABL10.21160377

Predicted pathways (KEGG)

RankGene SetZ-score
1* Primary bile acid biosynthesis_Homo sapiens_hsa001204.32519985
2Nitrogen metabolism_Homo sapiens_hsa009103.55902640
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.35127686
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.31876154
5Arginine biosynthesis_Homo sapiens_hsa002203.05164942
6Tryptophan metabolism_Homo sapiens_hsa003802.74486545
7Complement and coagulation cascades_Homo sapiens_hsa046102.73437771
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.70744813
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.61764145
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.57507261
11Fatty acid degradation_Homo sapiens_hsa000712.53134096
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.47729460
13Butanoate metabolism_Homo sapiens_hsa006502.24989525
14Pentose and glucuronate interconversions_Homo sapiens_hsa000402.24746565
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.10699869
16* Peroxisome_Homo sapiens_hsa041462.09008489
17Propanoate metabolism_Homo sapiens_hsa006402.01371378
18Chemical carcinogenesis_Homo sapiens_hsa052041.90884269
19Histidine metabolism_Homo sapiens_hsa003401.89723853
20Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.88735210
21Steroid hormone biosynthesis_Homo sapiens_hsa001401.86521432
22Fatty acid metabolism_Homo sapiens_hsa012121.81977367
23* PPAR signaling pathway_Homo sapiens_hsa033201.78649082
24beta-Alanine metabolism_Homo sapiens_hsa004101.76855610
25Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.72222603
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.71989352
27Staphylococcus aureus infection_Homo sapiens_hsa051501.69333011
28Drug metabolism - other enzymes_Homo sapiens_hsa009831.69254629
29Caffeine metabolism_Homo sapiens_hsa002321.68412865
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.66592463
31Retinol metabolism_Homo sapiens_hsa008301.66060463
322-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.63567206
33Selenocompound metabolism_Homo sapiens_hsa004501.58126824
34Phenylalanine metabolism_Homo sapiens_hsa003601.56514218
35Bile secretion_Homo sapiens_hsa049761.50281883
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.45630749
37Tyrosine metabolism_Homo sapiens_hsa003501.43384206
38Pyruvate metabolism_Homo sapiens_hsa006201.40629185
39Sulfur metabolism_Homo sapiens_hsa009201.38810325
40Fatty acid elongation_Homo sapiens_hsa000621.33548476
41Cysteine and methionine metabolism_Homo sapiens_hsa002701.32528034
42Starch and sucrose metabolism_Homo sapiens_hsa005001.27473504
43Biosynthesis of amino acids_Homo sapiens_hsa012301.21996858
44Folate biosynthesis_Homo sapiens_hsa007901.21983694
45Carbon metabolism_Homo sapiens_hsa012001.17023454
46ABC transporters_Homo sapiens_hsa020101.16601457
47Fat digestion and absorption_Homo sapiens_hsa049751.14877565
48Steroid biosynthesis_Homo sapiens_hsa001001.14379474
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.12040307
50Cyanoamino acid metabolism_Homo sapiens_hsa004601.11525562
51Maturity onset diabetes of the young_Homo sapiens_hsa049501.01387895
52Vitamin B6 metabolism_Homo sapiens_hsa007501.00270226
53Arginine and proline metabolism_Homo sapiens_hsa003300.99548390
54Vitamin digestion and absorption_Homo sapiens_hsa049770.96574776
55Sulfur relay system_Homo sapiens_hsa041220.94704610
56Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.93993131
57Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.92592107
58Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.90192565
59Lysine degradation_Homo sapiens_hsa003100.85615920
60Glutathione metabolism_Homo sapiens_hsa004800.74464229
61One carbon pool by folate_Homo sapiens_hsa006700.74317643
62Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.72479903
63Glycerolipid metabolism_Homo sapiens_hsa005610.68226485
64Pentose phosphate pathway_Homo sapiens_hsa000300.57833967
65Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.55476073
66Fatty acid biosynthesis_Homo sapiens_hsa000610.49072135
67* Metabolic pathways_Homo sapiens_hsa011000.46716350
68Other glycan degradation_Homo sapiens_hsa005110.46118852
69Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.39659358
70Prion diseases_Homo sapiens_hsa050200.37747286
71Fructose and mannose metabolism_Homo sapiens_hsa000510.27380483
72Galactose metabolism_Homo sapiens_hsa000520.27129165
73Pertussis_Homo sapiens_hsa051330.25716045
74alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.24713434
75Insulin resistance_Homo sapiens_hsa049310.21341559
76Adipocytokine signaling pathway_Homo sapiens_hsa049200.19872789
77Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.19075381
78Linoleic acid metabolism_Homo sapiens_hsa005910.18688451
79Glycerophospholipid metabolism_Homo sapiens_hsa005640.13957830
80Glucagon signaling pathway_Homo sapiens_hsa049220.07662395
81Sphingolipid metabolism_Homo sapiens_hsa006000.00780537
82AMPK signaling pathway_Homo sapiens_hsa041520.00502544
83Protein digestion and absorption_Homo sapiens_hsa04974-0.2350428
84Mineral absorption_Homo sapiens_hsa04978-0.2320683
85Amoebiasis_Homo sapiens_hsa05146-0.2288480
86Bladder cancer_Homo sapiens_hsa05219-0.2203854
87Lysosome_Homo sapiens_hsa04142-0.1967504
88Vascular smooth muscle contraction_Homo sapiens_hsa04270-0.1966532
89Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1961807
90Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1960723
91Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1949817
92Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1705364
93Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1704636
94Hepatitis C_Homo sapiens_hsa05160-0.1630722
95African trypanosomiasis_Homo sapiens_hsa05143-0.1612199
96Circadian rhythm_Homo sapiens_hsa04710-0.1556458
97Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1402356
98Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1268458
99Renin-angiotensin system_Homo sapiens_hsa04614-0.1232320
100Insulin signaling pathway_Homo sapiens_hsa04910-0.1231889
101Regulation of autophagy_Homo sapiens_hsa04140-0.1225820
102Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1224493
103Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1032928
104Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0837593
105ECM-receptor interaction_Homo sapiens_hsa04512-0.0794908
106Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0622909
107Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0462613
108N-Glycan biosynthesis_Homo sapiens_hsa00510-0.0409541

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