ACOXL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pattern specification involved in kidney development (GO:0061004)7.91627529
2cellular response to nitric oxide (GO:0071732)6.49447018
3response to xenobiotic stimulus (GO:0009410)5.66933956
4positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003605.56252147
5regulation of phospholipid biosynthetic process (GO:0071071)5.51023122
6response to nitric oxide (GO:0071731)5.48045810
7sodium-independent organic anion transport (GO:0043252)5.08107589
8lung lobe morphogenesis (GO:0060463)5.02928377
9cellular response to reactive nitrogen species (GO:1902170)5.01623197
10trivalent inorganic anion homeostasis (GO:0072506)4.98454291
11phosphate ion homeostasis (GO:0055062)4.98454291
12fatty acid elongation (GO:0030497)4.87982867
13dichotomous subdivision of an epithelial terminal unit (GO:0060600)4.86330531
14respiratory gaseous exchange (GO:0007585)4.69984322
15cellular anion homeostasis (GO:0030002)4.56669463
16positive regulation of endothelial cell differentiation (GO:0045603)4.48921038
17macrophage chemotaxis (GO:0048246)4.46766267
18negative regulation of interleukin-2 production (GO:0032703)4.45868350
19DNA deamination (GO:0045006)4.44266157
20adhesion of symbiont to host cell (GO:0044650)4.43718605
21virion attachment to host cell (GO:0019062)4.43718605
22morphogenesis of an endothelium (GO:0003159)4.41235132
23endothelial tube morphogenesis (GO:0061154)4.41235132
24protein localization to endosome (GO:0036010)4.36538256
25response to pheromone (GO:0019236)4.34433351
26phosphate ion transmembrane transport (GO:0035435)4.31337596
27sphingosine metabolic process (GO:0006670)4.27195848
28long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)4.27123312
29epithelial cell differentiation involved in prostate gland development (GO:0060742)4.22721137
30epithelial tube branching involved in lung morphogenesis (GO:0060441)4.16343102
31negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 4.14377632
32negative regulation of alcohol biosynthetic process (GO:1902931)4.07613322
33behavioral response to nicotine (GO:0035095)4.06950952
34regulation of endothelial cell differentiation (GO:0045601)4.05815487
35respiratory chain complex IV assembly (GO:0008535)4.04025558
36segment specification (GO:0007379)3.93020700
37piRNA metabolic process (GO:0034587)3.89822364
38water-soluble vitamin biosynthetic process (GO:0042364)3.89555410
39L-fucose catabolic process (GO:0042355)3.80910626
40fucose catabolic process (GO:0019317)3.80910626
41L-fucose metabolic process (GO:0042354)3.80910626
42fatty-acyl-CoA biosynthetic process (GO:0046949)3.78311295
43regulation of interleukin-2 biosynthetic process (GO:0045076)3.77788512
44diol metabolic process (GO:0034311)3.69785425
45regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 3.69728858
46cytochrome complex assembly (GO:0017004)3.66160887
47adhesion of symbiont to host (GO:0044406)3.56576177
48triglyceride biosynthetic process (GO:0019432)3.55341740
49negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)3.53892142
50regulation of vasculogenesis (GO:2001212)3.53671728
51platelet dense granule organization (GO:0060155)3.53012216
52Leydig cell differentiation (GO:0033327)3.48897415
53DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.45988002
54synapsis (GO:0007129)3.45527534
55phosphate ion transport (GO:0006817)3.41017726
56regulation of hippo signaling (GO:0035330)3.40772787
57branch elongation of an epithelium (GO:0060602)3.39560794
58neutral lipid biosynthetic process (GO:0046460)3.38604947
59acylglycerol biosynthetic process (GO:0046463)3.38604947
60somatic diversification of immune receptors via somatic mutation (GO:0002566)3.37413545
61somatic hypermutation of immunoglobulin genes (GO:0016446)3.37413545
62DNA double-strand break processing (GO:0000729)3.37201250
63negative regulation of fatty acid transport (GO:2000192)3.34745694
64kynurenine metabolic process (GO:0070189)3.33930935
65indole-containing compound catabolic process (GO:0042436)3.32778654
66indolalkylamine catabolic process (GO:0046218)3.32778654
67tryptophan catabolic process (GO:0006569)3.32778654
68detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.29897667
69protein complex biogenesis (GO:0070271)3.27948161
70epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.26106312
71antigen processing and presentation of endogenous antigen (GO:0019883)3.25829739
72indolalkylamine metabolic process (GO:0006586)3.23951566
73mesodermal cell differentiation (GO:0048333)3.22851967
74protein-cofactor linkage (GO:0018065)3.19821603
75regulation of hexokinase activity (GO:1903299)3.19278535
76regulation of glucokinase activity (GO:0033131)3.19278535
77signal peptide processing (GO:0006465)3.18996948
78phosphatidylglycerol acyl-chain remodeling (GO:0036148)3.17271490
79peptide catabolic process (GO:0043171)3.14136900
80DNA methylation involved in gamete generation (GO:0043046)3.13944672
81hemidesmosome assembly (GO:0031581)3.13782882
82negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)3.13100064
83mitochondrial respiratory chain complex assembly (GO:0033108)3.11257006
84antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.10953186
85antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.10953186
86DNA damage response, signal transduction resulting in transcription (GO:0042772)3.10866449
87axis elongation (GO:0003401)3.09401444
88long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.08903647
89kidney morphogenesis (GO:0060993)3.08185119
90negative regulation of transcription by competitive promoter binding (GO:0010944)3.07770956
91lung alveolus development (GO:0048286)3.04197146
92tryptophan metabolic process (GO:0006568)3.03865853
93sphingoid metabolic process (GO:0046519)3.03789690
94response to interleukin-6 (GO:0070741)3.01797172
95surfactant homeostasis (GO:0043129)21.0037586
96acyl-CoA biosynthetic process (GO:0071616)2.99679839
97thioester biosynthetic process (GO:0035384)2.99679839
98establishment of endothelial barrier (GO:0061028)2.96031099
99regulation of posttranscriptional gene silencing (GO:0060147)2.95241389
100regulation of gene silencing by miRNA (GO:0060964)2.95241389
101regulation of gene silencing by RNA (GO:0060966)2.95241389
102negative regulation of response to reactive oxygen species (GO:1901032)2.95155644
103branching involved in labyrinthine layer morphogenesis (GO:0060670)2.94849221
104reflex (GO:0060004)2.93801634
105negative regulation of telomere maintenance (GO:0032205)2.93695818
106receptor catabolic process (GO:0032801)2.92859921
107pseudouridine synthesis (GO:0001522)2.92143227
108regulation of meiosis I (GO:0060631)2.91335722
109cellular ketone body metabolic process (GO:0046950)2.89442097
110peptidyl-histidine modification (GO:0018202)2.88181486
111recombinational repair (GO:0000725)2.87589841
112establishment of protein localization to mitochondrial membrane (GO:0090151)2.87405968
113regulation of interleukin-13 production (GO:0032656)2.87046159
114double-strand break repair via homologous recombination (GO:0000724)2.86311564
115multicellular organismal water homeostasis (GO:0050891)2.85202198
116axoneme assembly (GO:0035082)2.85146832
117mannosylation (GO:0097502)2.83818017
118establishment of apical/basal cell polarity (GO:0035089)2.83814813
119positive regulation of glycoprotein biosynthetic process (GO:0010560)2.83553401
120lung secretory cell differentiation (GO:0061140)2.82778517
121photoreceptor cell maintenance (GO:0045494)2.81050567
122RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.80719513
123male meiosis I (GO:0007141)2.80663284
124regulation of glomerular filtration (GO:0003093)2.80380896
125detection of light stimulus involved in sensory perception (GO:0050962)2.80012352
126detection of light stimulus involved in visual perception (GO:0050908)2.80012352
127endothelial cell chemotaxis (GO:0035767)2.79167491
128male meiosis (GO:0007140)2.78905301
129sodium ion homeostasis (GO:0055078)2.78202880
130regulation of nuclear cell cycle DNA replication (GO:0033262)2.77824911
131mitochondrial respiratory chain complex I assembly (GO:0032981)2.76926584
132NADH dehydrogenase complex assembly (GO:0010257)2.76926584
133mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.76926584
134epithelial cilium movement (GO:0003351)2.76668638
135regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.74900913
136preassembly of GPI anchor in ER membrane (GO:0016254)2.71428896
137response to increased oxygen levels (GO:0036296)2.70888314
138response to hyperoxia (GO:0055093)2.70888314
139lung vasculature development (GO:0060426)2.70609902
140replication fork processing (GO:0031297)2.70196854
141striated muscle atrophy (GO:0014891)2.69122889
142negative regulation of DNA-dependent DNA replication (GO:2000104)2.67069060
143reciprocal meiotic recombination (GO:0007131)2.65934539
144reciprocal DNA recombination (GO:0035825)2.65934539
145response to vitamin A (GO:0033189)2.65410951
146inositol phosphate catabolic process (GO:0071545)2.64712032
147isotype switching (GO:0045190)2.64656390
148somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.64656390
149somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.64656390
150positive regulation of glycoprotein metabolic process (GO:1903020)2.63298359
151negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.62973940
152fatty-acyl-CoA metabolic process (GO:0035337)2.62754449
153embryonic foregut morphogenesis (GO:0048617)2.60925558
154ketone body metabolic process (GO:1902224)2.59806569
155glomerular epithelial cell development (GO:0072310)2.58448629
156water homeostasis (GO:0030104)2.58215061
157regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902253)2.58200727
158lung-associated mesenchyme development (GO:0060484)2.58142395
159negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.57458958
160cellular biogenic amine catabolic process (GO:0042402)2.57431629
161amine catabolic process (GO:0009310)2.57431629
162positive regulation of vasculogenesis (GO:2001214)2.57117412
163respiratory tube development (GO:0030323)2.57003451
164nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.56999689
165transcription elongation from RNA polymerase III promoter (GO:0006385)2.56767242
166termination of RNA polymerase III transcription (GO:0006386)2.56767242
167regulation of neurotransmitter uptake (GO:0051580)2.55801889
168branching involved in salivary gland morphogenesis (GO:0060445)2.54195539
169exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.54053550
170gas transport (GO:0015669)2.53876709
171protein K11-linked deubiquitination (GO:0035871)2.53416355
172negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.52892942
173negative regulation of translation, ncRNA-mediated (GO:0040033)2.52892942
174regulation of translation, ncRNA-mediated (GO:0045974)2.52892942
175skeletal muscle adaptation (GO:0043501)2.51345256
176protein localization to cilium (GO:0061512)2.50861832
177negative regulation of T cell proliferation (GO:0042130)2.50846005
178multicellular organism reproduction (GO:0032504)2.50795143
179protein neddylation (GO:0045116)2.50715457
180L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.50452295
181rhodopsin mediated signaling pathway (GO:0016056)2.50274609
182cornea development in camera-type eye (GO:0061303)2.48554236
183ubiquinone biosynthetic process (GO:0006744)2.48416780
184intracellular protein transmembrane import (GO:0044743)2.47264752
185regulation of mesoderm development (GO:2000380)2.46028893
186prenylation (GO:0097354)2.45465311
187protein prenylation (GO:0018342)2.45465311
188single strand break repair (GO:0000012)2.45391649
189regulation of cilium movement (GO:0003352)2.44394082
190behavioral response to ethanol (GO:0048149)2.43631023
191indole-containing compound metabolic process (GO:0042430)2.43432592
192DNA demethylation (GO:0080111)2.42946189
193regulation of rhodopsin mediated signaling pathway (GO:0022400)2.42504307
194neural tube formation (GO:0001841)2.42213440
195dopamine transport (GO:0015872)2.41363210
196polyol catabolic process (GO:0046174)2.39217558
197cilium organization (GO:0044782)2.39215647
198protein K6-linked ubiquitination (GO:0085020)2.38465201
199chemical homeostasis within a tissue (GO:0048875)16.6593030

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.44987837
2ZNF274_21170338_ChIP-Seq_K562_Hela3.93934228
3GATA1_22025678_ChIP-Seq_K562_Human3.77156668
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.38069093
5VDR_22108803_ChIP-Seq_LS180_Human3.35928241
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.26553573
7EGR1_19374776_ChIP-ChIP_THP-1_Human3.14905121
8TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.01914880
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.77883926
10GBX2_23144817_ChIP-Seq_PC3_Human2.67994350
11CLOCK_20551151_ChIP-Seq_293T_Human2.67198317
12SALL1_21062744_ChIP-ChIP_HESCs_Human2.57018190
13ESR1_20079471_ChIP-ChIP_T-47D_Human2.51448063
14FLI1_27457419_Chip-Seq_LIVER_Mouse2.49384871
15TRIM28_21343339_ChIP-Seq_HEK293_Human2.46324080
16E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.42140540
17* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.41953246
18IGF1R_20145208_ChIP-Seq_DFB_Human2.41233595
19POU3F2_20337985_ChIP-ChIP_501MEL_Human2.41120292
20HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.33727183
21KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.31017484
22NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.27456084
23ESR2_21235772_ChIP-Seq_MCF-7_Human2.26782456
24GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.21478492
25MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.20537751
26EWS_26573619_Chip-Seq_HEK293_Human2.20481753
27FUS_26573619_Chip-Seq_HEK293_Human2.19343131
28ESR1_21235772_ChIP-Seq_MCF-7_Human2.15002575
29GABP_17652178_ChIP-ChIP_JURKAT_Human2.10364726
30PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.10146206
31* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.09213491
32CTBP2_25329375_ChIP-Seq_LNCAP_Human2.07651400
33P300_19829295_ChIP-Seq_ESCs_Human2.04215248
34TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.02077251
35NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.00782937
36SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.00648429
37RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.00112317
38GATA2_21666600_ChIP-Seq_HMVEC_Human1.97779421
39PCGF2_27294783_Chip-Seq_ESCs_Mouse1.96131377
40PPAR_26484153_Chip-Seq_NCI-H1993_Human1.95546902
41EST1_17652178_ChIP-ChIP_JURKAT_Human1.92321161
42NOTCH1_21737748_ChIP-Seq_TLL_Human1.91470636
43FOXO3_23340844_ChIP-Seq_DLD1_Human1.89269199
44STAT6_21828071_ChIP-Seq_BEAS2B_Human1.88773756
45ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.87596770
46FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.87037867
47STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.86909221
48RACK7_27058665_Chip-Seq_MCF-7_Human1.85933577
49RUNX1_27514584_Chip-Seq_MCF-7_Human1.84790449
50STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.84719584
51RARG_19884340_ChIP-ChIP_MEFs_Mouse1.84125477
52KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.82941363
53CTBP1_25329375_ChIP-Seq_LNCAP_Human1.80524604
54SOX2_27498859_Chip-Seq_STOMACH_Mouse1.79667912
55* SOX2_20726797_ChIP-Seq_SW620_Human1.78300103
56THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.77560259
57ER_23166858_ChIP-Seq_MCF-7_Human1.77382860
58KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.76341986
59HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.73987290
60EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.72270326
61SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.71843416
62ZNF263_19887448_ChIP-Seq_K562_Human1.70460770
63TAF15_26573619_Chip-Seq_HEK293_Human1.68874116
64IRF8_21731497_ChIP-ChIP_J774_Mouse1.65866281
65AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.65159652
66IRF1_19129219_ChIP-ChIP_H3396_Human1.64596720
67GATA4_25053715_ChIP-Seq_YYC3_Human1.64333977
68CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.60869948
69MYC_18940864_ChIP-ChIP_HL60_Human1.58902814
70SALL4_18804426_ChIP-ChIP_XEN_Mouse1.58856229
71BCAT_22108803_ChIP-Seq_LS180_Human1.56790772
72TP63_17297297_ChIP-ChIP_HaCaT_Human1.54001469
73TBX20_22328084_ChIP-Seq_HEART_Mouse1.53960902
74TBX20_22080862_ChIP-Seq_HEART_Mouse1.53960902
75ELK3_25401928_ChIP-Seq_HUVEC_Human1.53651287
76KDM2B_26808549_Chip-Seq_SUP-B15_Human1.53129323
77TP53_22573176_ChIP-Seq_HFKS_Human1.52065865
78ELK1_19687146_ChIP-ChIP_HELA_Human1.48264936
79UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.47551055
80MYB_21317192_ChIP-Seq_ERMYB_Mouse1.46679488
81STAT3_23295773_ChIP-Seq_U87_Human1.46212842
82IRF8_22096565_ChIP-ChIP_GC-B_Human1.45127496
83CBP_20019798_ChIP-Seq_JUKART_Human1.45120726
84IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.45120726
85P63_26484246_Chip-Seq_KERATINOCYTES_Human1.44868826
86NANOG_19829295_ChIP-Seq_ESCs_Human1.44746190
87SOX2_19829295_ChIP-Seq_ESCs_Human1.44746190
88HIF1A_21447827_ChIP-Seq_MCF-7_Human1.44617583
89PIAS1_25552417_ChIP-Seq_VCAP_Human1.43588497
90VDR_23849224_ChIP-Seq_CD4+_Human1.43085687
91MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.41454295
92* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.41387653
93GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.40626158
94PCGF2_27294783_Chip-Seq_NPCs_Mouse1.39402252
95LXR_22158963_ChIP-Seq_LIVER_Mouse1.39174783
96SUZ12_27294783_Chip-Seq_NPCs_Mouse1.38717139
97TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.37437986
98NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.37319372
99FOXA1_27270436_Chip-Seq_PROSTATE_Human1.36311555
100FOXA1_25329375_ChIP-Seq_VCAP_Human1.36311555
101* TCF4_22108803_ChIP-Seq_LS180_Human1.35203028
102* SMAD4_21799915_ChIP-Seq_A2780_Human1.35052163
103* TCF4_23295773_ChIP-Seq_U87_Human1.34583463
104* AR_25329375_ChIP-Seq_VCAP_Human1.33689585
105NFE2_27457419_Chip-Seq_LIVER_Mouse1.33462265
106NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.33141428
107SOX9_24532713_ChIP-Seq_HFSC_Mouse1.32318419
108* SPI1_23127762_ChIP-Seq_K562_Human1.31700223
109EZH2_27294783_Chip-Seq_NPCs_Mouse1.31664191
110SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.31629484
111JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.31118481
112ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.30588004
113GATA6_25053715_ChIP-Seq_YYC3_Human1.30550825
114MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.30285582
115* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.29372481
116* AHR_22903824_ChIP-Seq_MCF-7_Human1.25893192
117KLF5_20875108_ChIP-Seq_MESCs_Mouse1.25592832
118NR3C1_21868756_ChIP-Seq_MCF10A_Human1.23909905
119TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.23563426
120TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23153645
121POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.23153645
122ETS1_20019798_ChIP-Seq_JURKAT_Human1.22509226
123SMAD3_21741376_ChIP-Seq_EPCs_Human1.22226474
124ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.22097325
125* VDR_24763502_ChIP-Seq_THP-1_Human1.20899865
126AR_20517297_ChIP-Seq_VCAP_Human1.19084683
127FOXA1_21572438_ChIP-Seq_LNCaP_Human1.19048175
128SRF_21415370_ChIP-Seq_HL-1_Mouse1.19038628
129* CDX2_22108803_ChIP-Seq_LS180_Human1.18500098
130VDR_21846776_ChIP-Seq_THP-1_Human1.18067757
131IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.17515267
132TOP2B_26459242_ChIP-Seq_MCF-7_Human1.17402073
133NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.17310685
134CJUN_26792858_Chip-Seq_BT549_Human1.17230521
135SMAD4_21741376_ChIP-Seq_EPCs_Human1.16754232
136GATA3_21878914_ChIP-Seq_MCF-7_Human1.16658480
137KDM2B_26808549_Chip-Seq_DND41_Human1.15998392
138* RUNX2_22187159_ChIP-Seq_PCA_Human1.15620867
139TCF7_22412390_ChIP-Seq_EML_Mouse1.14619290
140SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.14322963
141SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.14322963
142HOXB7_26014856_ChIP-Seq_BT474_Human1.14300182
143PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.13916170
144TCF3_18692474_ChIP-Seq_MEFs_Mouse1.13707049
145CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.13647558
146P300_27058665_Chip-Seq_ZR-75-30cells_Human1.13309480
147SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.13012117
148EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.12451477
149CRX_20693478_ChIP-Seq_RETINA_Mouse1.12316368
150PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.11712934
151* KDM2B_26808549_Chip-Seq_K562_Human1.11643370
152NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.11344400
153* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.10345614
154BMI1_23680149_ChIP-Seq_NPCS_Mouse1.09865818
155IRF8_27001747_Chip-Seq_BMDM_Mouse1.09658631
156POU5F1_16153702_ChIP-ChIP_HESCs_Human1.09617283
157JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.09151068
158FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.09127722
159GATA1_19941826_ChIP-Seq_K562_Human1.08897098
160* CDX2_20551321_ChIP-Seq_CACO-2_Human1.08344717
161MAF_26560356_Chip-Seq_TH1_Human1.08096483
162UBF1/2_26484160_Chip-Seq_HMECs_Human1.07915842
163* NANOG_18555785_Chip-Seq_ESCs_Mouse1.07748899
164NCOR_22424771_ChIP-Seq_293T_Human1.07697775
165GATA3_27048872_Chip-Seq_THYMUS_Human1.07650377
166SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07620932
167GATA3_24758297_ChIP-Seq_MCF-7_Human1.07163291
168CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.07124479
169ATF3_27146783_Chip-Seq_COLON_Human1.07055545
170KLF5_25053715_ChIP-Seq_YYC3_Human1.06995069
171FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.05633682
172GATA2_19941826_ChIP-Seq_K562_Human1.04928863
173BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.04759183
174AUTS2_25519132_ChIP-Seq_293T-REX_Human1.04312466
175* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.04273634
176KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.04227396
177UTX_26944678_Chip-Seq_JUKART_Human1.04096344
178* P53_22387025_ChIP-Seq_ESCs_Mouse1.03693985
179NFIB_24661679_ChIP-Seq_LUNG_Mouse1.02848989
180OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02687219
181MYB_26560356_Chip-Seq_TH2_Human1.02087167
182FOXP3_21729870_ChIP-Seq_TREG_Human1.01489985
183PADI4_21655091_ChIP-ChIP_MCF-7_Human1.01226463
184* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.01161240
185CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.01123882
186* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.01012954
187* STAT3_18555785_Chip-Seq_ESCs_Mouse0.99711602
188ETV2_25802403_ChIP-Seq_MESCs_Mouse0.99173738
189SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.98351112
190FLI1_21867929_ChIP-Seq_TH2_Mouse0.97906302
191PRDM14_20953172_ChIP-Seq_ESCs_Human0.96635641
192FOXM1_26456572_ChIP-Seq_MCF-7_Human0.96122974
193TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.95736635
194* P300_18555785_Chip-Seq_ESCs_Mouse0.95684388
195UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.94879260
196CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.94636191
197NCOR1_26117541_ChIP-Seq_K562_Human0.93907913
198* SUZ12_18555785_Chip-Seq_ESCs_Mouse0.93655670

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001958_emphysema5.40042664
2MP0008995_early_reproductive_senescence4.82881288
3MP0008004_abnormal_stomach_pH4.48360379
4MP0008877_abnormal_DNA_methylation4.09258345
5MP0005083_abnormal_biliary_tract3.76203439
6MP0003724_increased_susceptibility_to3.39349155
7MP0001177_atelectasis2.79624532
8MP0002133_abnormal_respiratory_system2.68222319
9MP0005388_respiratory_system_phenotype2.68222319
10MP0003195_calcinosis2.66494273
11MP0002295_abnormal_pulmonary_circulatio2.61718967
12MP0005551_abnormal_eye_electrophysiolog2.46724690
13MP0010368_abnormal_lymphatic_system2.42780294
14MP0002837_dystrophic_cardiac_calcinosis2.41840820
15MP0005645_abnormal_hypothalamus_physiol2.39850208
16MP0006292_abnormal_olfactory_placode2.28376850
17MP0002254_reproductive_system_inflammat2.27687326
18MP0010234_abnormal_vibrissa_follicle2.22469065
19MP0003787_abnormal_imprinting2.21804649
20MP0002138_abnormal_hepatobiliary_system2.20970747
21MP0006072_abnormal_retinal_apoptosis2.19467275
22MP0008058_abnormal_DNA_repair2.16535359
23MP0000372_irregular_coat_pigmentation2.15090792
24MP0002876_abnormal_thyroid_physiology2.12678713
25MP0003191_abnormal_cellular_cholesterol2.05801056
26MP0002102_abnormal_ear_morphology2.04391771
27MP0005379_endocrine/exocrine_gland_phen2.01299527
28MP0008872_abnormal_physiological_respon2.00054218
29MP0004782_abnormal_surfactant_physiolog10.7594534
30MP0002163_abnormal_gland_morphology1.98368275
31MP0009046_muscle_twitch1.97431012
32MP0001968_abnormal_touch/_nociception1.96949131
33MP0000569_abnormal_digit_pigmentation1.95254349
34MP0004133_heterotaxia1.89594032
35MP0002736_abnormal_nociception_after1.87462779
36MP0005253_abnormal_eye_physiology1.84514198
37MP0000427_abnormal_hair_cycle1.84121573
38MP0003646_muscle_fatigue1.77193567
39MP0001501_abnormal_sleep_pattern1.66449982
40MP0000566_synostosis1.61224086
41MP0009745_abnormal_behavioral_response1.60889252
42MP0002938_white_spotting1.60452697
43MP0003786_premature_aging1.57237432
44MP0005058_abnormal_lysosome_morphology1.56934731
45MP0005167_abnormal_blood-brain_barrier1.55610902
46MP0002796_impaired_skin_barrier1.54822658
47MP0000631_abnormal_neuroendocrine_gland1.53691697
48MP0004147_increased_porphyrin_level1.52144158
49MP0009840_abnormal_foam_cell1.51753500
50MP0001485_abnormal_pinna_reflex1.49771859
51MP0005646_abnormal_pituitary_gland1.49115786
52MP0003011_delayed_dark_adaptation1.46654494
53MP0005174_abnormal_tail_pigmentation1.46226113
54MP0002638_abnormal_pupillary_reflex1.45396473
55MP0000537_abnormal_urethra_morphology1.45122806
56MP0004185_abnormal_adipocyte_glucose1.44461842
57MP0004043_abnormal_pH_regulation1.44389542
58MP0005084_abnormal_gallbladder_morpholo1.41698903
59MP0002132_abnormal_respiratory_system1.40880682
60MP0003136_yellow_coat_color1.40834452
61MP0002160_abnormal_reproductive_system1.39184588
62MP0005075_abnormal_melanosome_morpholog1.35509012
63MP0010678_abnormal_skin_adnexa1.33999825
64MP0001984_abnormal_olfaction1.33226926
65MP0001175_abnormal_lung_morphology1.33134938
66MP0002272_abnormal_nervous_system1.31831723
67MP0003453_abnormal_keratinocyte_physiol1.31214768
68MP0002405_respiratory_system_inflammati1.29459050
69MP0001986_abnormal_taste_sensitivity1.28721618
70MP0004142_abnormal_muscle_tone1.28028123
71MP0001879_abnormal_lymphatic_vessel1.27873249
72MP0000685_abnormal_immune_system1.25070491
73MP0008057_abnormal_DNA_replication1.24934385
74MP0001851_eye_inflammation1.24119274
75MP0005389_reproductive_system_phenotype1.22498276
76MP0001486_abnormal_startle_reflex1.21191497
77MP0003693_abnormal_embryo_hatching1.18973494
78MP0004947_skin_inflammation1.18015252
79MP0005410_abnormal_fertilization1.16679294
80MP0000383_abnormal_hair_follicle1.15610243
81MP0001529_abnormal_vocalization1.15294472
82MP0005023_abnormal_wound_healing1.14968281
83MP0003303_peritoneal_inflammation1.13698418
84MP0003880_abnormal_central_pattern1.13519574
85MP0003436_decreased_susceptibility_to1.12357042
86MP0003698_abnormal_male_reproductive1.11477392
87MP0003950_abnormal_plasma_membrane1.11332933
88MP0005275_abnormal_skin_tensile1.11219786
89MP0001929_abnormal_gametogenesis1.11201532
90MP0004885_abnormal_endolymph1.10749327
91MP0010386_abnormal_urinary_bladder1.10006934
92MP0002693_abnormal_pancreas_physiology1.09794676
93MP0002735_abnormal_chemical_nociception1.09250990
94MP0002210_abnormal_sex_determination1.08382262
95MP0002928_abnormal_bile_duct1.06907587
96MP0005332_abnormal_amino_acid1.03300988
97MP0010094_abnormal_chromosome_stability1.02141013
98MP0002557_abnormal_social/conspecific_i1.01180503
99MP0003115_abnormal_respiratory_system0.99590729
100MP0003448_altered_tumor_morphology0.99131510
101MP0006276_abnormal_autonomic_nervous0.99093717
102MP0004215_abnormal_myocardial_fiber0.99017749
103MP0002098_abnormal_vibrissa_morphology0.98957634
104MP0000653_abnormal_sex_gland0.98939160
105MP0003878_abnormal_ear_physiology0.98637473
106MP0005377_hearing/vestibular/ear_phenot0.98637473
107MP0008260_abnormal_autophagy0.98462467
108MP0001145_abnormal_male_reproductive0.97752960
109MP0003252_abnormal_bile_duct0.97305287
110MP0003566_abnormal_cell_adhesion0.96008837
111MP0003890_abnormal_embryonic-extraembry0.94410514
112MP0002277_abnormal_respiratory_mucosa0.93295269
113MP0009697_abnormal_copulation0.93197258
114MP0003937_abnormal_limbs/digits/tail_de0.92157480
115MP0003121_genomic_imprinting0.92068771
116MP0005408_hypopigmentation0.92033777
117MP0002572_abnormal_emotion/affect_behav0.90929783
118MP0002751_abnormal_autonomic_nervous0.90383089
119MP0001944_abnormal_pancreas_morphology0.90370469
120MP0005076_abnormal_cell_differentiation0.90019367
121MP0004924_abnormal_behavior0.89531542
122MP0005386_behavior/neurological_phenoty0.89531542
123MP0005166_decreased_susceptibility_to0.88664102
124MP0001764_abnormal_homeostasis0.88462012
125MP0002733_abnormal_thermal_nociception0.88066919
126MP0006035_abnormal_mitochondrial_morpho0.87604379
127MP0006054_spinal_hemorrhage0.87280157
128MP0001919_abnormal_reproductive_system0.87028558
129MP0004145_abnormal_muscle_electrophysio0.86914237
130MP0003122_maternal_imprinting0.86912181
131MP0005367_renal/urinary_system_phenotyp0.85429270
132MP0000516_abnormal_urinary_system0.85429270
133MP0001970_abnormal_pain_threshold0.85382222
134MP0005025_abnormal_response_to0.85195287
135MP0002064_seizures0.85164570
136MP0003137_abnormal_impulse_conducting0.83892333
137MP0003283_abnormal_digestive_organ0.83879255
138MP0001324_abnormal_eye_pigmentation0.83744908
139MP0001293_anophthalmia0.82942645
140MP0009780_abnormal_chondrocyte_physiolo0.82923429
141MP0005647_abnormal_sex_gland0.82861490
142MP0010352_gastrointestinal_tract_polyps0.82803588
143MP0000579_abnormal_nail_morphology0.82355317
144MP0005164_abnormal_response_to0.79587061
145MP0000343_altered_response_to0.77793239
146MP0000534_abnormal_ureter_morphology0.77783502
147MP0001790_abnormal_immune_system0.75172958
148MP0005387_immune_system_phenotype0.75172958
149MP0002118_abnormal_lipid_homeostasis0.74741031
150MP0004510_myositis0.73176733
151MP0004272_abnormal_basement_membrane0.73172393
152MP0009785_altered_susceptibility_to0.72592205
153MP0000465_gastrointestinal_hemorrhage0.71725139
154MP0000627_abnormal_mammary_gland0.71271702
155MP0004883_abnormal_blood_vessel0.69095399
156MP0010155_abnormal_intestine_physiology0.69024862
157MP0001835_abnormal_antigen_presentation0.68655641
158MP0003300_gastrointestinal_ulcer0.68588982
159MP0000249_abnormal_blood_vessel0.67212313
160MP0003705_abnormal_hypodermis_morpholog0.66642456
161MP0001943_abnormal_respiration0.66448911
162MP0005501_abnormal_skin_physiology0.66290884
163MP0003718_maternal_effect0.64016297
164MP0005464_abnormal_platelet_physiology0.63864411
165MP0000462_abnormal_digestive_system0.63311711
166MP0006082_CNS_inflammation0.62523678
167MP0001346_abnormal_lacrimal_gland0.62349919
168MP0001533_abnormal_skeleton_physiology0.60756530
169MP0001545_abnormal_hematopoietic_system0.60318614
170MP0005397_hematopoietic_system_phenotyp0.60318614
171MP0000639_abnormal_adrenal_gland0.60097780
172MP0002877_abnormal_melanocyte_morpholog0.59819028
173MP0000647_abnormal_sebaceous_gland0.59053776
174MP0001849_ear_inflammation0.58146794
175MP0001216_abnormal_epidermal_layer0.57805247
176MP0001664_abnormal_digestion0.56761319
177MP0003075_altered_response_to0.56420923
178MP0004264_abnormal_extraembryonic_tissu0.56383720
179MP0002234_abnormal_pharynx_morphology0.53038346
180MP0003763_abnormal_thymus_physiology0.51966844
181MP0000767_abnormal_smooth_muscle0.51781652
182MP0001666_abnormal_nutrient_absorption0.51749513
183MP0005085_abnormal_gallbladder_physiolo0.50725199
184MP0006138_congestive_heart_failure0.50583954
185MP0002419_abnormal_innate_immunity0.49129613
186MP0008875_abnormal_xenobiotic_pharmacok0.48675205
187MP0002723_abnormal_immune_serum0.48325108
188MP0002136_abnormal_kidney_physiology0.48205378
189MP0005395_other_phenotype0.45955900
190MP0003091_abnormal_cell_migration0.45243277
191MP0003828_pulmonary_edema0.45190942
192MP0002925_abnormal_cardiovascular_devel0.45168299

Predicted human phenotypes

RankGene SetZ-score
1Tubulointerstitial fibrosis (HP:0005576)6.87035628
2Tachypnea (HP:0002789)6.71093545
3Respiratory distress (HP:0002098)6.29981477
4Gout (HP:0001997)5.84331681
5Onycholysis (HP:0001806)5.00780734
6Renal salt wasting (HP:0000127)4.94086801
7Hyperactive renin-angiotensin system (HP:0000841)4.78936669
8Chronic bronchitis (HP:0004469)4.48154803
9Pancreatic cysts (HP:0001737)4.28386837
10Ulnar bowing (HP:0003031)4.23982876
11Neurofibrillary tangles (HP:0002185)4.21077587
12Pancreatic fibrosis (HP:0100732)4.14034111
13Tubulointerstitial abnormality (HP:0001969)3.77907586
14Polycythemia (HP:0001901)3.75904650
15Chronic otitis media (HP:0000389)3.69705198
16True hermaphroditism (HP:0010459)3.62766761
17Tubulointerstitial nephritis (HP:0001970)3.61498685
18Abnormality of midbrain morphology (HP:0002418)3.58047365
19Molar tooth sign on MRI (HP:0002419)3.58047365
20Congenital stationary night blindness (HP:0007642)3.47909097
21Cerebral inclusion bodies (HP:0100314)3.28636697
22Nephronophthisis (HP:0000090)3.24208615
23Abnormality of the nasal mucosa (HP:0000433)3.23698458
24Hematochezia (HP:0002573)3.18229472
25Stenosis of the external auditory canal (HP:0000402)3.15948952
26Thyroid-stimulating hormone excess (HP:0002925)3.14874729
27Pustule (HP:0200039)2.95296276
28Hyperkalemia (HP:0002153)2.91907124
29Abnormality of the renal medulla (HP:0100957)2.91101068
30Medial flaring of the eyebrow (HP:0010747)2.90178093
31Tubular atrophy (HP:0000092)2.84247157
32Long toe (HP:0010511)2.84178097
33Bowed forearm bones (HP:0003956)2.82905566
34Bowing of the arm (HP:0006488)2.82905566
35Abnormal rod and cone electroretinograms (HP:0008323)2.77566042
36Eczematoid dermatitis (HP:0000976)2.77518016
37Stomach cancer (HP:0012126)2.76185835
38Attenuation of retinal blood vessels (HP:0007843)2.73459222
39Spontaneous hematomas (HP:0007420)2.72522811
40Bronchitis (HP:0012387)2.71390300
41Type II lissencephaly (HP:0007260)2.70053523
42Neonatal respiratory distress (HP:0002643)2.68745919
43Bile duct proliferation (HP:0001408)2.66920555
44Abnormal biliary tract physiology (HP:0012439)2.66920555
45Gaze-evoked nystagmus (HP:0000640)2.66487084
46Broad metatarsal (HP:0001783)2.65072539
47Cystic liver disease (HP:0006706)2.63217882
48Visceral angiomatosis (HP:0100761)2.59950051
49Abolished electroretinogram (ERG) (HP:0000550)2.59063316
50Loss of speech (HP:0002371)2.57721312
51Milia (HP:0001056)2.57576445
52Polydipsia (HP:0001959)2.56179785
53Abnormal drinking behavior (HP:0030082)2.56179785
54Fragile nails (HP:0001808)2.55653388
55Hyperuricemia (HP:0002149)2.55396031
56Increased purine levels (HP:0004368)2.55396031
57Pendular nystagmus (HP:0012043)2.55047920
58Abnormality of the fetal cardiovascular system (HP:0010948)2.51978631
59Abnormal umbilical cord blood vessels (HP:0011403)2.51978631
60Single umbilical artery (HP:0001195)2.51978631
61Abnormality of macrophages (HP:0004311)2.51231449
62Supranuclear gaze palsy (HP:0000605)2.50647334
63Hemangiomatosis (HP:0007461)2.48381988
64Acute necrotizing encephalopathy (HP:0006965)2.47933985
65Sclerocornea (HP:0000647)2.43271250
66Chronic hepatic failure (HP:0100626)2.39656401
67Colon cancer (HP:0003003)2.39480123
68Hypothermia (HP:0002045)2.38588544
69Progressive macrocephaly (HP:0004481)2.32771065
70Large for gestational age (HP:0001520)2.32153477
71Hypotension (HP:0002615)2.31773443
72Plantar hyperkeratosis (HP:0007556)2.30329469
73Methylmalonic acidemia (HP:0002912)2.30115979
74Osteolytic defects of the phalanges of the hand (HP:0009771)2.28589848
75Osteolytic defects of the hand bones (HP:0009699)2.28589848
76Aplasia/Hypoplasia of the tongue (HP:0010295)2.25863366
77Increased CSF lactate (HP:0002490)2.25411712
78Acute encephalopathy (HP:0006846)2.22559125
79Abnormality of the pons (HP:0007361)2.21989561
80Prolonged neonatal jaundice (HP:0006579)2.21927090
81Abnormality of chloride homeostasis (HP:0011422)2.21689522
82Intestinal atresia (HP:0011100)2.20403883
83Methylmalonic aciduria (HP:0012120)2.20196444
84Progressive inability to walk (HP:0002505)2.20074400
85Cerebral aneurysm (HP:0004944)2.19464919
86Subacute progressive viral hepatitis (HP:0006572)2.18951826
87Inability to walk (HP:0002540)2.17254824
88Congenital primary aphakia (HP:0007707)2.16070070
89Hypomagnesemia (HP:0002917)2.15379160
90Hyperventilation (HP:0002883)2.14779898
91Mitochondrial inheritance (HP:0001427)2.14542053
92Gait imbalance (HP:0002141)2.14092835
93Hypoplasia of the pons (HP:0012110)2.12871182
94Increased IgE level (HP:0003212)2.11363607
95Ketoacidosis (HP:0001993)2.10838472
96Esophageal varix (HP:0002040)2.09674659
97Polyuria (HP:0000103)2.06989803
98Anencephaly (HP:0002323)2.06815668
99Absent rod-and cone-mediated responses on ERG (HP:0007688)2.06050625
100Furrowed tongue (HP:0000221)2.05457237
101Aplasia involving bones of the upper limbs (HP:0009823)2.05405408
102Aplasia of the phalanges of the hand (HP:0009802)2.05405408
103Aplasia involving bones of the extremities (HP:0009825)2.05405408
104Hyperglycinuria (HP:0003108)2.03669084
105Genital tract atresia (HP:0001827)2.02380170
106Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.01937969
107Abnormality of alanine metabolism (HP:0010916)2.01937969
108Hyperalaninemia (HP:0003348)2.01937969
109Abnormal mitochondria in muscle tissue (HP:0008316)2.01815433
110Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.01781565
111Interstitial pulmonary disease (HP:0006530)15.8591856
112Optic nerve hypoplasia (HP:0000609)1.99979707
113Glomerulosclerosis (HP:0000096)1.98321927
1143-Methylglutaconic aciduria (HP:0003535)1.98317786
115Nephrogenic diabetes insipidus (HP:0009806)1.98120719
116Keratoconus (HP:0000563)1.97513296
117Increased corneal curvature (HP:0100692)1.97513296
118Hyperaldosteronism (HP:0000859)1.96643506
119Renal cortical cysts (HP:0000803)1.95542281
120Rapidly progressive (HP:0003678)1.94556183
121Aplasia/Hypoplasia of the spleen (HP:0010451)1.94439722
122Broad-based gait (HP:0002136)1.93677081
123Optic disc pallor (HP:0000543)1.92616283
124Nasal polyposis (HP:0100582)1.90131105
125Male pseudohermaphroditism (HP:0000037)1.90042133
126Supernumerary spleens (HP:0009799)1.89695216
127Vaginal atresia (HP:0000148)1.87909947
128Megalencephaly (HP:0001355)1.87363339
129Bronchomalacia (HP:0002780)1.87169433
130Decreased electroretinogram (ERG) amplitude (HP:0000654)1.86972872
131Abnormality of the umbilical cord (HP:0010881)1.86664549
132Hemiparesis (HP:0001269)1.86318904
133Turricephaly (HP:0000262)1.86086420
134Progressive cerebellar ataxia (HP:0002073)1.85960096
135Congenital hepatic fibrosis (HP:0002612)1.85664832
136Abnormal albumin level (HP:0012116)1.84872983
137Hypoalbuminemia (HP:0003073)1.84872983
138Aplasia/Hypoplasia of the tibia (HP:0005772)1.84690114
139Abnormality of purine metabolism (HP:0004352)1.84569254
140Male infertility (HP:0003251)1.84485476
141Pulmonary hypertension (HP:0002092)1.84336290
142Abnormality of macular pigmentation (HP:0008002)1.83211281
143Microcytic anemia (HP:0001935)1.82920489
144Broad distal phalanx of finger (HP:0009836)1.82169077
145Bronchiectasis (HP:0002110)1.80120624
146Constricted visual fields (HP:0001133)1.79046715
147Hyperinsulinemic hypoglycemia (HP:0000825)1.78924631
148Increased serum lactate (HP:0002151)1.78861278
149Lissencephaly (HP:0001339)1.78688749
150Dandy-Walker malformation (HP:0001305)1.78399669
151Recurrent gram-negative bacterial infections (HP:0005420)1.78146310
152Decreased circulating renin level (HP:0003351)1.78065490
153Asplenia (HP:0001746)1.77144135
154Abnormality of serine family amino acid metabolism (HP:0010894)1.75158951
155Abnormality of glycine metabolism (HP:0010895)1.75158951
156Abnormality of vitamin B metabolism (HP:0004340)1.74908783
157Atrophic scars (HP:0001075)1.74779333
158Shallow orbits (HP:0000586)1.74135007
159Abnormality of the ileum (HP:0001549)1.74094755
160Genetic anticipation (HP:0003743)1.73945464
161Cerebellar dysplasia (HP:0007033)1.73897276
162Congenital, generalized hypertrichosis (HP:0004540)1.73758975
163Aplasia/Hypoplasia of the fovea (HP:0008060)1.73585134
164Hypoplasia of the fovea (HP:0007750)1.73585134
165Fair hair (HP:0002286)1.73497788
166Restrictive lung disease (HP:0002091)1.73102625
167Postaxial foot polydactyly (HP:0001830)1.72426384
168Hepatic necrosis (HP:0002605)1.71977771
169Sloping forehead (HP:0000340)1.71864225
170Thick nail (HP:0001805)1.71816805
171Severe visual impairment (HP:0001141)1.71723642
172Meckel diverticulum (HP:0002245)1.71659389
173Lipid accumulation in hepatocytes (HP:0006561)1.71275233
174Recurrent abscess formation (HP:0002722)1.69530406
175Abnormality of the 2nd finger (HP:0004100)1.69399492
176Growth hormone excess (HP:0000845)1.67878973
177Cortical dysplasia (HP:0002539)1.66069704
178Abnormality of renin-angiotensin system (HP:0000847)1.65565818
179Humeroradial synostosis (HP:0003041)1.65070744
180Synostosis involving the elbow (HP:0003938)1.65070744
181Partial duplication of thumb phalanx (HP:0009944)1.64243164
182Abnormality of the labia minora (HP:0012880)1.59306354
183Abnormality of the renal cortex (HP:0011035)1.59050806
184Conjunctival telangiectasia (HP:0000524)1.58705018
185Ankle contracture (HP:0006466)1.58602437
186Fused cervical vertebrae (HP:0002949)1.57562751
187Hyponatremia (HP:0002902)1.57144738
188Split foot (HP:0001839)1.56879420
189Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.56190796
190Osteomyelitis (HP:0002754)1.55968521
191Abnormality of the gastric mucosa (HP:0004295)1.54637741
192Recurrent bronchitis (HP:0002837)1.53547298
193Dehydration (HP:0001944)1.51322389
194Shawl scrotum (HP:0000049)1.49779835
195Tetany (HP:0001281)1.49670349
196Hypoplasia of dental enamel (HP:0006297)1.48370672
197Arterial tortuosity (HP:0005116)1.47570285

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.89619725
2STK245.66847029
3FGFR24.74861014
4ZAP703.62605339
5LRRK23.58355525
6TIE12.89800267
7STK102.85492591
8WNK32.80312611
9BMPR1B2.76176119
10EPHB12.65528318
11TRIB32.60110333
12ZAK2.57105656
13NUAK12.54338661
14ADRBK22.47754066
15ACVR1B2.46439089
16MAP4K22.39520040
17INSRR2.37716027
18TGFBR22.35365159
19MST42.33398793
20TAOK32.26645305
21MKNK22.23383292
22ILK2.09311540
23ERN12.06970847
24PDGFRB2.02110722
25TRIM282.00524361
26PAK41.95182574
27FGFR41.90993679
28EPHA21.80988431
29KSR21.80608538
30MAPK151.75688113
31TNIK1.74452275
32MAP3K91.67545293
33WNK41.63131454
34OXSR11.60446484
35EIF2AK31.59636664
36BRSK21.59329180
37PINK11.56132580
38MAP3K41.52316678
39LMTK21.48417808
40CDK61.47898964
41EPHA31.46770468
42CASK1.41241508
43TAF11.39595541
44MAP4K11.39582729
45RIPK11.39083341
46MAPK131.34374934
47PLK31.34277164
48STK38L1.30182442
49MKNK11.29214549
50DAPK21.27786474
51STK391.27063521
52LATS11.23167973
53VRK11.22998141
54FER1.22988248
55VRK21.20644934
56MAP3K31.20279736
57PAK31.19527018
58MST1R1.17285532
59PTK61.16901717
60TLK11.16155644
61FGFR31.11920548
62PLK21.11316549
63GSK3A1.06035422
64STK161.05265995
65CSK1.02365495
66PHKG10.99935062
67PHKG20.99935062
68NME10.99471073
69PRKCE0.98103287
70PRKCG0.94856529
71DYRK20.93651208
72CAMKK20.91449019
73GRK10.90548977
74MOS0.89763492
75EPHB20.89359863
76NLK0.88989566
77CAMK1D0.88950641
78PNCK0.86603133
79MAP3K20.86223998
80BCR0.82427994
81RPS6KA40.82234011
82TSSK60.81581757
83EEF2K0.81507058
84CSNK1G20.81331714
85FGR0.79773891
86PRKCI0.79182179
87CSNK1G30.79024354
88CDK190.78420136
89MAP3K80.78250247
90BCKDK0.77875940
91EGFR0.77476548
92SIK10.77431433
93PDGFRA0.76893976
94NTRK30.71703620
95MARK20.71306451
96ERBB30.71261721
97MAP2K70.71150861
98TBK10.71029220
99TEC0.68944826
100MAP2K60.68543906
101PTK2B0.67654743
102STK30.67514431
103CDC70.67482621
104PRKD10.67160812
105TYK20.66916914
106PASK0.65500514
107ADRBK10.65092140
108PRKCQ0.64506550
109PLK40.63691280
110MAP2K30.63562344
111ITK0.63023430
112MET0.62016506
113CHUK0.60925342
114PLK10.60789975
115TRPM70.60707381
116FGFR10.60559618
117TYRO30.60271826
118CSNK1A1L0.59473201
119BLK0.58529064
120PKN20.58477885
121EIF2AK10.57110185
122IRAK10.57040767
123AKT30.56338146
124TAOK10.55827072
125KDR0.55560535
126IKBKE0.55054901
127PRKD20.54330027
128MELK0.53324325
129IRAK30.53237678
130NEK90.52548645
131CHEK20.51418566
132BMX0.51294528
133HIPK20.51231361
134MAP3K10.51075879
135LATS20.51030540
136ABL10.48886790
137TNK20.48805419
138MAP2K20.48756035
139WEE10.48239245
140JAK30.47977789
141MAP3K60.47456477
142CSNK1A10.47270145
143CAMK2A0.47104946
144MUSK0.46211871
145ATM0.45889190
146JAK10.45814071
147PRKAA10.44489004
148PRKCH0.44049230
149TTK0.43857694
150EIF2AK20.42714145
151DYRK1B0.42499925
152RET0.42452748
153FLT30.41946435
154RPS6KA50.41706954
155STK110.41579377
156JAK20.41471695
157PTK20.40415421
158ATR0.39623736
159MAPKAPK50.38130185
160IKBKB0.37159899
161TGFBR10.36182803
162PIM10.34897951
163PRKACA0.33766631
164CSNK1D0.33638964
165SRPK10.32576237
166DAPK30.31887533
167CSNK1G10.30667034
168PRKAA20.30220245
169PRKCA0.29380431
170CSF1R0.28933857
171NEK10.28922131
172MAP3K70.28820031
173MAPKAPK30.28604180
174PDPK10.28571377
175TXK0.27855022
176STK40.26714397
177GRK60.26384238
178MATK0.25674234
179TESK10.24933533
180MAP2K10.24887693
181ERBB20.23428487
182PRKCD0.23199218
183MAP3K130.22245853
184BUB10.22155308

Predicted pathways (KEGG)

RankGene SetZ-score
1Mineral absorption_Homo sapiens_hsa049783.44764345
2Fatty acid biosynthesis_Homo sapiens_hsa000612.98547727
3Protein export_Homo sapiens_hsa030602.69299912
4Maturity onset diabetes of the young_Homo sapiens_hsa049502.64312975
5Phototransduction_Homo sapiens_hsa047442.62285895
6Fatty acid elongation_Homo sapiens_hsa000622.61222614
7RNA polymerase_Homo sapiens_hsa030202.57007005
8Lysosome_Homo sapiens_hsa041422.54340682
9Selenocompound metabolism_Homo sapiens_hsa004502.48914172
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.42505400
11Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049602.38834406
12Homologous recombination_Homo sapiens_hsa034402.34997890
13Butanoate metabolism_Homo sapiens_hsa006502.33808284
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.19769395
15Oxidative phosphorylation_Homo sapiens_hsa001902.07427214
16Adherens junction_Homo sapiens_hsa045202.05805945
17Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.03431124
18Ether lipid metabolism_Homo sapiens_hsa005652.00111820
19Nitrogen metabolism_Homo sapiens_hsa009101.99666505
20Leukocyte transendothelial migration_Homo sapiens_hsa046701.99334017
21Linoleic acid metabolism_Homo sapiens_hsa005911.94534539
22alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.88618368
23Caffeine metabolism_Homo sapiens_hsa002321.87426456
24One carbon pool by folate_Homo sapiens_hsa006701.85317821
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.84546691
26Basal transcription factors_Homo sapiens_hsa030221.84525983
27Proteasome_Homo sapiens_hsa030501.83582898
28Malaria_Homo sapiens_hsa051441.82254832
29Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.82180557
30Phagosome_Homo sapiens_hsa041451.80300912
31ECM-receptor interaction_Homo sapiens_hsa045121.80002614
32Propanoate metabolism_Homo sapiens_hsa006401.79263347
33Fanconi anemia pathway_Homo sapiens_hsa034601.75579421
34AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.74412870
35Pertussis_Homo sapiens_hsa051331.72835558
36Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.63582701
37Tryptophan metabolism_Homo sapiens_hsa003801.63081751
38Non-homologous end-joining_Homo sapiens_hsa034501.61830935
39VEGF signaling pathway_Homo sapiens_hsa043701.60957709
40Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.60633728
41Rheumatoid arthritis_Homo sapiens_hsa053231.57488443
42Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.57319433
43Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.55182586
44Histidine metabolism_Homo sapiens_hsa003401.51850476
45Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.50338873
46RNA degradation_Homo sapiens_hsa030181.48588214
47Glycerophospholipid metabolism_Homo sapiens_hsa005641.45589786
48Parkinsons disease_Homo sapiens_hsa050121.45475539
49Small cell lung cancer_Homo sapiens_hsa052221.38500516
50Tight junction_Homo sapiens_hsa045301.37126582
51Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.32758124
52Renin-angiotensin system_Homo sapiens_hsa046141.31506007
53Nicotine addiction_Homo sapiens_hsa050331.30271931
54Renal cell carcinoma_Homo sapiens_hsa052111.29583286
55Bladder cancer_Homo sapiens_hsa052191.29037882
56Toxoplasmosis_Homo sapiens_hsa051451.28316813
57NF-kappa B signaling pathway_Homo sapiens_hsa040641.25946029
58Regulation of autophagy_Homo sapiens_hsa041401.24751940
59Peroxisome_Homo sapiens_hsa041461.23287965
60Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.22800832
61Pancreatic cancer_Homo sapiens_hsa052121.22537878
62Hippo signaling pathway_Homo sapiens_hsa043901.20800858
63Leishmaniasis_Homo sapiens_hsa051401.20196219
64Focal adhesion_Homo sapiens_hsa045101.16441785
65Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.15401050
66Thyroid cancer_Homo sapiens_hsa052161.14809177
67Sphingolipid metabolism_Homo sapiens_hsa006001.11790091
68Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.11312870
69TNF signaling pathway_Homo sapiens_hsa046681.11044586
70Amoebiasis_Homo sapiens_hsa051461.10977784
71Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.10555337
72Antigen processing and presentation_Homo sapiens_hsa046121.09985038
73ABC transporters_Homo sapiens_hsa020101.07900340
74Salmonella infection_Homo sapiens_hsa051321.07260791
75Osteoclast differentiation_Homo sapiens_hsa043801.06441651
76Purine metabolism_Homo sapiens_hsa002301.06110075
77Cysteine and methionine metabolism_Homo sapiens_hsa002701.05725232
78Taste transduction_Homo sapiens_hsa047421.04514507
79Huntingtons disease_Homo sapiens_hsa050161.03988377
80Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.00981300
81Fatty acid metabolism_Homo sapiens_hsa012120.99345746
82Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.98812937
83beta-Alanine metabolism_Homo sapiens_hsa004100.98571318
84Pyrimidine metabolism_Homo sapiens_hsa002400.97868476
85Primary bile acid biosynthesis_Homo sapiens_hsa001200.97755456
86Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.97081936
87Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.97063400
88Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.95912645
89Sulfur metabolism_Homo sapiens_hsa009200.95645178
90Apoptosis_Homo sapiens_hsa042100.95628468
91Mismatch repair_Homo sapiens_hsa034300.95477475
92Dorso-ventral axis formation_Homo sapiens_hsa043200.95003227
93Regulation of actin cytoskeleton_Homo sapiens_hsa048100.94952865
94Endocytosis_Homo sapiens_hsa041440.92830403
95Insulin secretion_Homo sapiens_hsa049110.92304708
96Tuberculosis_Homo sapiens_hsa051520.92300357
97Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.92101413
98Collecting duct acid secretion_Homo sapiens_hsa049660.89157065
99Endometrial cancer_Homo sapiens_hsa052130.88771287
100Olfactory transduction_Homo sapiens_hsa047400.88301330
101Steroid biosynthesis_Homo sapiens_hsa001000.87008349
102Acute myeloid leukemia_Homo sapiens_hsa052210.86062650
103Adipocytokine signaling pathway_Homo sapiens_hsa049200.85446051
104T cell receptor signaling pathway_Homo sapiens_hsa046600.84718081
105Retinol metabolism_Homo sapiens_hsa008300.84617127
106Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.84153663
107Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.84123913
108Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.82910466
109Intestinal immune network for IgA production_Homo sapiens_hsa046720.81376129
110Chemical carcinogenesis_Homo sapiens_hsa052040.81293394
111Platelet activation_Homo sapiens_hsa046110.80683461
112Rap1 signaling pathway_Homo sapiens_hsa040150.80566055
113Steroid hormone biosynthesis_Homo sapiens_hsa001400.80033925
114TGF-beta signaling pathway_Homo sapiens_hsa043500.79826836
115Chronic myeloid leukemia_Homo sapiens_hsa052200.79728659
116Hepatitis C_Homo sapiens_hsa051600.79124760
117Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.78634702
118Sphingolipid signaling pathway_Homo sapiens_hsa040710.78502346
119B cell receptor signaling pathway_Homo sapiens_hsa046620.78392275
120Ovarian steroidogenesis_Homo sapiens_hsa049130.77712821
121Alzheimers disease_Homo sapiens_hsa050100.77634433
122RNA transport_Homo sapiens_hsa030130.76815092
123Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.76725954
124Hematopoietic cell lineage_Homo sapiens_hsa046400.76634070
125Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.76267530
126Metabolic pathways_Homo sapiens_hsa011000.75603743
127Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.75327163
128Colorectal cancer_Homo sapiens_hsa052100.74984501
129Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.74974537
130Arachidonic acid metabolism_Homo sapiens_hsa005900.74703384
131Proteoglycans in cancer_Homo sapiens_hsa052050.74626672
132Pentose and glucuronate interconversions_Homo sapiens_hsa000400.74290081
133Inositol phosphate metabolism_Homo sapiens_hsa005620.74046228
134Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.72063234
135Graft-versus-host disease_Homo sapiens_hsa053320.71340004
136MicroRNAs in cancer_Homo sapiens_hsa052060.71334342
137Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.70874703
138Shigellosis_Homo sapiens_hsa051310.70683567
139Viral myocarditis_Homo sapiens_hsa054160.70172954
140Serotonergic synapse_Homo sapiens_hsa047260.69182515
141Prolactin signaling pathway_Homo sapiens_hsa049170.68559598
142Primary immunodeficiency_Homo sapiens_hsa053400.68546489
143Morphine addiction_Homo sapiens_hsa050320.67502436
144Fatty acid degradation_Homo sapiens_hsa000710.67090990
145Influenza A_Homo sapiens_hsa051640.66371975
146Staphylococcus aureus infection_Homo sapiens_hsa051500.65558757
147Cardiac muscle contraction_Homo sapiens_hsa042600.64781510
148Circadian rhythm_Homo sapiens_hsa047100.63723682
149Type I diabetes mellitus_Homo sapiens_hsa049400.63722275
150Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.62979725
151Pathways in cancer_Homo sapiens_hsa052000.62729457
152Vibrio cholerae infection_Homo sapiens_hsa051100.61483847
153Prion diseases_Homo sapiens_hsa050200.61302460
154Chemokine signaling pathway_Homo sapiens_hsa040620.60646916
155Jak-STAT signaling pathway_Homo sapiens_hsa046300.58251748
156Legionellosis_Homo sapiens_hsa051340.57837385
157Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.56621485
158Notch signaling pathway_Homo sapiens_hsa043300.54733807
159Toll-like receptor signaling pathway_Homo sapiens_hsa046200.54244603
160NOD-like receptor signaling pathway_Homo sapiens_hsa046210.53826990
161Salivary secretion_Homo sapiens_hsa049700.52872170
162Vitamin B6 metabolism_Homo sapiens_hsa007500.52286304
163Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.52284899
164Prostate cancer_Homo sapiens_hsa052150.51659972
165GABAergic synapse_Homo sapiens_hsa047270.51161225
166Insulin resistance_Homo sapiens_hsa049310.50528723
167Fat digestion and absorption_Homo sapiens_hsa049750.50490518
168Transcriptional misregulation in cancer_Homo sapiens_hsa052020.48137150
169HTLV-I infection_Homo sapiens_hsa051660.47579052
170Gastric acid secretion_Homo sapiens_hsa049710.47525689
171Arginine and proline metabolism_Homo sapiens_hsa003300.47080377
172Measles_Homo sapiens_hsa051620.46638682
173Circadian entrainment_Homo sapiens_hsa047130.46011390
174Nucleotide excision repair_Homo sapiens_hsa034200.45501500
175Viral carcinogenesis_Homo sapiens_hsa052030.45190646
176Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.45064160
177Glutamatergic synapse_Homo sapiens_hsa047240.45055351
178Choline metabolism in cancer_Homo sapiens_hsa052310.44062805
179Folate biosynthesis_Homo sapiens_hsa007900.42490130
180Base excision repair_Homo sapiens_hsa034100.42460581
181Glutathione metabolism_Homo sapiens_hsa004800.42445102
182FoxO signaling pathway_Homo sapiens_hsa040680.41716696
183SNARE interactions in vesicular transport_Homo sapiens_hsa041300.39787475
184Glycerolipid metabolism_Homo sapiens_hsa005610.39697592
185Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.38620550
186Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.38136633
187Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.37062069

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