

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 6.89733248 |
| 2 | ATP synthesis coupled proton transport (GO:0015986) | 6.37407012 |
| 3 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 6.37407012 |
| 4 | proteasome assembly (GO:0043248) | 5.03012185 |
| 5 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 4.95640358 |
| 6 | cullin deneddylation (GO:0010388) | 4.92434421 |
| 7 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 4.82357111 |
| 8 | respiratory electron transport chain (GO:0022904) | 4.73857068 |
| 9 | electron transport chain (GO:0022900) | 4.62368557 |
| 10 | protein deneddylation (GO:0000338) | 4.53400978 |
| 11 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 4.34963507 |
| 12 | NADH dehydrogenase complex assembly (GO:0010257) | 4.34470405 |
| 13 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 4.34470405 |
| 14 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 4.34470405 |
| 15 | protein neddylation (GO:0045116) | 4.23297738 |
| 16 | GTP biosynthetic process (GO:0006183) | 4.19697450 |
| 17 | regulation of cellular amino acid metabolic process (GO:0006521) | 4.13380105 |
| 18 | protein complex biogenesis (GO:0070271) | 4.07858429 |
| 19 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 4.07322047 |
| 20 | chaperone-mediated protein transport (GO:0072321) | 4.05815264 |
| 21 | ribosomal small subunit assembly (GO:0000028) | 3.98634609 |
| 22 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.96634842 |
| 23 | negative regulation of ligase activity (GO:0051352) | 3.95019326 |
| 24 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.95019326 |
| 25 | ribosomal large subunit biogenesis (GO:0042273) | 3.93275348 |
| 26 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.93015065 |
| 27 | maturation of SSU-rRNA (GO:0030490) | 3.92216937 |
| 28 | ribosomal small subunit biogenesis (GO:0042274) | 3.92143646 |
| 29 | rRNA modification (GO:0000154) | 3.91091434 |
| 30 | protoporphyrinogen IX biosynthetic process (GO:0006782) | 3.86264178 |
| 31 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.85611883 |
| 32 | viral transcription (GO:0019083) | 3.85295880 |
| 33 | translational termination (GO:0006415) | 3.82688409 |
| 34 | UTP biosynthetic process (GO:0006228) | 3.80948691 |
| 35 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.77685454 |
| 36 | establishment of integrated proviral latency (GO:0075713) | 3.77586587 |
| 37 | regulation of mitochondrial translation (GO:0070129) | 3.74144549 |
| 38 | protoporphyrinogen IX metabolic process (GO:0046501) | 3.73553515 |
| 39 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.69295825 |
| 40 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.69295825 |
| 41 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 3.67000522 |
| 42 | respiratory chain complex IV assembly (GO:0008535) | 3.64351389 |
| 43 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.63747157 |
| 44 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.63747157 |
| 45 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.63747157 |
| 46 | oxidative phosphorylation (GO:0006119) | 3.63732620 |
| 47 | guanosine-containing compound biosynthetic process (GO:1901070) | 3.62334571 |
| 48 | protein-cofactor linkage (GO:0018065) | 3.59910255 |
| 49 | purine ribonucleoside triphosphate biosynthetic process (GO:0009206) | 3.59844629 |
| 50 | 7-methylguanosine mRNA capping (GO:0006370) | 3.59820705 |
| 51 | purine nucleoside triphosphate biosynthetic process (GO:0009145) | 3.59028819 |
| 52 | DNA damage response, detection of DNA damage (GO:0042769) | 3.55336036 |
| 53 | establishment of protein localization to mitochondrion (GO:0072655) | 3.55246956 |
| 54 | 7-methylguanosine RNA capping (GO:0009452) | 3.54325909 |
| 55 | RNA capping (GO:0036260) | 3.54325909 |
| 56 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.53980637 |
| 57 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.53980637 |
| 58 | protein targeting to mitochondrion (GO:0006626) | 3.52031419 |
| 59 | purine nucleobase biosynthetic process (GO:0009113) | 3.51562711 |
| 60 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.51228870 |
| 61 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.50444283 |
| 62 | translation (GO:0006412) | 3.50257496 |
| 63 | cotranslational protein targeting to membrane (GO:0006613) | 3.50074360 |
| 64 | DNA double-strand break processing (GO:0000729) | 3.48712696 |
| 65 | termination of RNA polymerase III transcription (GO:0006386) | 3.46440689 |
| 66 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.46440689 |
| 67 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.45077642 |
| 68 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 3.45047496 |
| 69 | formation of translation preinitiation complex (GO:0001731) | 3.44704229 |
| 70 | cytochrome complex assembly (GO:0017004) | 3.44556372 |
| 71 | ATP biosynthetic process (GO:0006754) | 3.42743823 |
| 72 | translational elongation (GO:0006414) | 3.41295822 |
| 73 | protein targeting to ER (GO:0045047) | 3.40428244 |
| 74 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.39626505 |
| 75 | CENP-A containing nucleosome assembly (GO:0034080) | 3.38930234 |
| 76 | water-soluble vitamin biosynthetic process (GO:0042364) | 3.37702676 |
| 77 | positive regulation of ligase activity (GO:0051351) | 3.37682316 |
| 78 | UTP metabolic process (GO:0046051) | 3.37366087 |
| 79 | protein localization to mitochondrion (GO:0070585) | 3.36478419 |
| 80 | nucleobase biosynthetic process (GO:0046112) | 3.32968681 |
| 81 | translational initiation (GO:0006413) | 3.32331102 |
| 82 | protein localization to endoplasmic reticulum (GO:0070972) | 3.27969701 |
| 83 | deoxyribonucleotide biosynthetic process (GO:0009263) | 3.27599176 |
| 84 | regulation of cellular amine metabolic process (GO:0033238) | 3.27146069 |
| 85 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 3.26708500 |
| 86 | chromatin remodeling at centromere (GO:0031055) | 3.26234673 |
| 87 | ribonucleoside triphosphate biosynthetic process (GO:0009201) | 3.24963377 |
| 88 | non-recombinational repair (GO:0000726) | 3.23154223 |
| 89 | double-strand break repair via nonhomologous end joining (GO:0006303) | 3.23154223 |
| 90 | establishment of viral latency (GO:0019043) | 3.23082443 |
| 91 | spliceosomal snRNP assembly (GO:0000387) | 3.22674439 |
| 92 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 3.21610999 |
| 93 | cellular protein complex disassembly (GO:0043624) | 3.20817203 |
| 94 | 2-deoxyribonucleotide biosynthetic process (GO:0009265) | 3.20805445 |
| 95 | deoxyribose phosphate biosynthetic process (GO:0046385) | 3.20805445 |
| 96 | cellular component biogenesis (GO:0044085) | 3.20331466 |
| 97 | histone exchange (GO:0043486) | 3.20187993 |
| 98 | DNA replication initiation (GO:0006270) | 3.19772466 |
| 99 | DNA strand elongation involved in DNA replication (GO:0006271) | 3.19376013 |
| 100 | telomere maintenance via semi-conservative replication (GO:0032201) | 3.19346241 |
| 101 | inner mitochondrial membrane organization (GO:0007007) | 3.17959382 |
| 102 | DNA replication checkpoint (GO:0000076) | 3.17576624 |
| 103 | DNA strand elongation (GO:0022616) | 3.17317885 |
| 104 | ribonucleoprotein complex biogenesis (GO:0022613) | 3.15421402 |
| 105 | transcription elongation from RNA polymerase I promoter (GO:0006362) | 3.14671813 |
| 106 | L-methionine salvage (GO:0071267) | 3.14045097 |
| 107 | L-methionine biosynthetic process (GO:0071265) | 3.14045097 |
| 108 | amino acid salvage (GO:0043102) | 3.14045097 |
| 109 | dopamine transport (GO:0015872) | 3.08081237 |
| 110 | rRNA methylation (GO:0031167) | 3.07632439 |
| 111 | viral life cycle (GO:0019058) | 3.07414310 |
| 112 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 3.06983187 |
| 113 | mitotic metaphase plate congression (GO:0007080) | 3.06821046 |
| 114 | nucleobase-containing small molecule interconversion (GO:0015949) | 3.06812406 |
| 115 | pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148) | 3.06751454 |
| 116 | DNA ligation (GO:0006266) | 3.03760350 |
| 117 | maturation of 5.8S rRNA (GO:0000460) | 3.03160064 |
| 118 | pseudouridine synthesis (GO:0001522) | 3.03109917 |
| 119 | DNA catabolic process, exonucleolytic (GO:0000738) | 3.01344719 |
| 120 | regulation of mitotic spindle checkpoint (GO:1903504) | 3.00856772 |
| 121 | regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266) | 3.00856772 |
| 122 | transcription from mitochondrial promoter (GO:0006390) | 2.94903488 |
| 123 | DNA replication-independent nucleosome organization (GO:0034724) | 2.91086268 |
| 124 | DNA replication-independent nucleosome assembly (GO:0006336) | 2.91086268 |
| 125 | regulation of ligase activity (GO:0051340) | 2.88806120 |
| 126 | ribosome assembly (GO:0042255) | 2.88608395 |
| 127 | IMP biosynthetic process (GO:0006188) | 2.86431127 |
| 128 | rRNA processing (GO:0006364) | 2.83264786 |
| 129 | telomere maintenance via recombination (GO:0000722) | 2.82095892 |
| 130 | histone mRNA metabolic process (GO:0008334) | 2.79035009 |
| 131 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 2.78590582 |
| 132 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 2.78590582 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 5.03174916 |
| 2 | E2F7_22180533_ChIP-Seq_HELA_Human | 4.52761042 |
| 3 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 4.26779825 |
| 4 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.12286073 |
| 5 | * EST1_17652178_ChIP-ChIP_JURKAT_Human | 4.11406954 |
| 6 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.71282327 |
| 7 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 3.68656434 |
| 8 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.54639935 |
| 9 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 3.44420709 |
| 10 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 3.43033604 |
| 11 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 3.20549895 |
| 12 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 3.17169268 |
| 13 | * CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 3.16815847 |
| 14 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 3.15243170 |
| 15 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 3.04902735 |
| 16 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.95000798 |
| 17 | * E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.92038093 |
| 18 | * MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.78440006 |
| 19 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.67279953 |
| 20 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 2.50701050 |
| 21 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.47525134 |
| 22 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.41206120 |
| 23 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 2.34558493 |
| 24 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 2.30795649 |
| 25 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.29918405 |
| 26 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 2.28473434 |
| 27 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.27557257 |
| 28 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.22390950 |
| 29 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.18750717 |
| 30 | XRN2_22483619_ChIP-Seq_HELA_Human | 2.16594439 |
| 31 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.14422406 |
| 32 | TTF2_22483619_ChIP-Seq_HELA_Human | 2.08867910 |
| 33 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 2.06099665 |
| 34 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.05932151 |
| 35 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 2.03717150 |
| 36 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 2.02581778 |
| 37 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.99825506 |
| 38 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.89743422 |
| 39 | * PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.84301363 |
| 40 | * GABP_19822575_ChIP-Seq_HepG2_Human | 1.83913819 |
| 41 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 1.80865094 |
| 42 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.79602158 |
| 43 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.73096391 |
| 44 | * FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.69701169 |
| 45 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.63595659 |
| 46 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.61051660 |
| 47 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.59806131 |
| 48 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.56686049 |
| 49 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.55237945 |
| 50 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.53826381 |
| 51 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.42971988 |
| 52 | * MYC_18940864_ChIP-ChIP_HL60_Human | 1.40742117 |
| 53 | FUS_26573619_Chip-Seq_HEK293_Human | 1.40181071 |
| 54 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.39067277 |
| 55 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.37533842 |
| 56 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.37207524 |
| 57 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.34261615 |
| 58 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.33347498 |
| 59 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.27088738 |
| 60 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 1.21061933 |
| 61 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.19229676 |
| 62 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.18713604 |
| 63 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.18045487 |
| 64 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.17010187 |
| 65 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.16717322 |
| 66 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.16698580 |
| 67 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.16510097 |
| 68 | EWS_26573619_Chip-Seq_HEK293_Human | 1.13860478 |
| 69 | * SOX17_20123909_ChIP-Seq_XEN_Mouse | 1.09981144 |
| 70 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 1.05828538 |
| 71 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.05683910 |
| 72 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.03386060 |
| 73 | PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 1.03053838 |
| 74 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 1.03002574 |
| 75 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 1.00827804 |
| 76 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 0.99840631 |
| 77 | VDR_22108803_ChIP-Seq_LS180_Human | 0.98719664 |
| 78 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 0.98541486 |
| 79 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 0.98339667 |
| 80 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 0.98091505 |
| 81 | * CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 0.95593452 |
| 82 | KDM5A_27292631_Chip-Seq_BREAST_Human | 0.94538677 |
| 83 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 0.93892991 |
| 84 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 0.90245680 |
| 85 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 0.88011370 |
| 86 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 0.84766190 |
| 87 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 0.84431313 |
| 88 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 0.84310523 |
| 89 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 0.83225244 |
| 90 | FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse | 0.82830124 |
| 91 | HTT_18923047_ChIP-ChIP_STHdh_Human | 0.82700044 |
| 92 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 0.82632443 |
| 93 | SOX2_19030024_ChIP-ChIP_MESCs_Mouse | 0.81571527 |
| 94 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 0.80217235 |
| 95 | TP53_22573176_ChIP-Seq_HFKS_Human | 0.79476953 |
| 96 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.79416668 |
| 97 | RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse | 0.78782330 |
| 98 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 0.77518466 |
| 99 | CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse | 0.76070961 |
| 100 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 0.74295439 |
| 101 | P300_19829295_ChIP-Seq_ESCs_Human | 0.73455185 |
| 102 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 0.72855624 |
| 103 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 0.72360797 |
| 104 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.71975410 |
| 105 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 0.71171929 |
| 106 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 0.69812690 |
| 107 | CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.68995447 |
| 108 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 0.66334180 |
| 109 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 0.66151538 |
| 110 | NANOG_18358816_ChIP-ChIP_MESCs_Mouse | 0.65623090 |
| 111 | REST_19997604_ChIP-ChIP_NEURONS_Mouse | 0.63877786 |
| 112 | CIITA_25753668_ChIP-Seq_RAJI_Human | 0.62898986 |
| 113 | * BMI1_23680149_ChIP-Seq_NPCS_Mouse | 0.62665522 |
| 114 | SOX2_18692474_ChIP-Seq_MEFs_Mouse | 0.62520016 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0001529_abnormal_vocalization | 3.68288716 |
| 2 | MP0009379_abnormal_foot_pigmentation | 3.62638439 |
| 3 | MP0003693_abnormal_embryo_hatching | 3.48332194 |
| 4 | MP0004957_abnormal_blastocyst_morpholog | 3.46045441 |
| 5 | MP0003806_abnormal_nucleotide_metabolis | 3.25477325 |
| 6 | MP0004147_increased_porphyrin_level | 3.23687695 |
| 7 | MP0003880_abnormal_central_pattern | 3.21857896 |
| 8 | MP0003123_paternal_imprinting | 2.69940821 |
| 9 | MP0010094_abnormal_chromosome_stability | 2.67417055 |
| 10 | MP0003656_abnormal_erythrocyte_physiolo | 2.60986232 |
| 11 | MP0008932_abnormal_embryonic_tissue | 2.56500341 |
| 12 | MP0006276_abnormal_autonomic_nervous | 2.55066993 |
| 13 | MP0008057_abnormal_DNA_replication | 2.53388251 |
| 14 | MP0001905_abnormal_dopamine_level | 2.40928937 |
| 15 | MP0003111_abnormal_nucleus_morphology | 2.33338089 |
| 16 | MP0006036_abnormal_mitochondrial_physio | 2.31193468 |
| 17 | MP0003077_abnormal_cell_cycle | 2.29123335 |
| 18 | MP0002736_abnormal_nociception_after | 2.19256082 |
| 19 | MP0006072_abnormal_retinal_apoptosis | 2.15920250 |
| 20 | MP0003718_maternal_effect | 2.13983944 |
| 21 | MP0006035_abnormal_mitochondrial_morpho | 2.12433759 |
| 22 | MP0009697_abnormal_copulation | 2.08869799 |
| 23 | MP0008058_abnormal_DNA_repair | 2.08409060 |
| 24 | MP0003186_abnormal_redox_activity | 2.04136215 |
| 25 | MP0003122_maternal_imprinting | 1.99340967 |
| 26 | MP0001293_anophthalmia | 1.87588771 |
| 27 | MP0001968_abnormal_touch/_nociception | 1.76716258 |
| 28 | MP0008877_abnormal_DNA_methylation | 1.65525966 |
| 29 | MP0002102_abnormal_ear_morphology | 1.59010295 |
| 30 | MP0005084_abnormal_gallbladder_morpholo | 1.58618106 |
| 31 | MP0003121_genomic_imprinting | 1.56921648 |
| 32 | MP0003315_abnormal_perineum_morphology | 1.47298712 |
| 33 | MP0002735_abnormal_chemical_nociception | 1.46528406 |
| 34 | MP0002234_abnormal_pharynx_morphology | 1.43687771 |
| 35 | MP0002938_white_spotting | 1.42446215 |
| 36 | MP0003136_yellow_coat_color | 1.38946716 |
| 37 | MP0003011_delayed_dark_adaptation | 1.34499250 |
| 38 | MP0002139_abnormal_hepatobiliary_system | 1.34310095 |
| 39 | MP0001764_abnormal_homeostasis | 1.31759239 |
| 40 | MP0005253_abnormal_eye_physiology | 1.31586979 |
| 41 | MP0001188_hyperpigmentation | 1.30942983 |
| 42 | MP0000566_synostosis | 1.28346435 |
| 43 | MP0003567_abnormal_fetal_cardiomyocyte | 1.28256473 |
| 44 | MP0000537_abnormal_urethra_morphology | 1.28218667 |
| 45 | MP0004142_abnormal_muscle_tone | 1.26097110 |
| 46 | MP0008872_abnormal_physiological_respon | 1.23972645 |
| 47 | MP0008995_early_reproductive_senescence | 1.22877520 |
| 48 | MP0008789_abnormal_olfactory_epithelium | 1.21602247 |
| 49 | MP0001440_abnormal_grooming_behavior | 1.17679182 |
| 50 | MP0006292_abnormal_olfactory_placode | 1.15605011 |
| 51 | MP0003786_premature_aging | 1.14831682 |
| 52 | MP0005551_abnormal_eye_electrophysiolog | 1.14584202 |
| 53 | MP0004133_heterotaxia | 1.13591259 |
| 54 | MP0002160_abnormal_reproductive_system | 1.10966146 |
| 55 | MP0001727_abnormal_embryo_implantation | 1.10841609 |
| 56 | MP0001730_embryonic_growth_arrest | 1.10275132 |
| 57 | MP0001286_abnormal_eye_development | 1.09072227 |
| 58 | MP0000631_abnormal_neuroendocrine_gland | 1.08728833 |
| 59 | MP0005266_abnormal_metabolism | 1.06877915 |
| 60 | MP0005075_abnormal_melanosome_morpholog | 1.04822372 |
| 61 | MP0009745_abnormal_behavioral_response | 1.03683255 |
| 62 | MP0002233_abnormal_nose_morphology | 1.02337996 |
| 63 | MP0001929_abnormal_gametogenesis | 1.02332763 |
| 64 | MP0002638_abnormal_pupillary_reflex | 1.02109032 |
| 65 | MP0008007_abnormal_cellular_replicative | 1.01160436 |
| 66 | MP0003890_abnormal_embryonic-extraembry | 0.99039986 |
| 67 | MP0005646_abnormal_pituitary_gland | 0.98456851 |
| 68 | MP0005636_abnormal_mineral_homeostasis | 0.98329427 |
| 69 | MP0010030_abnormal_orbit_morphology | 0.98295783 |
| 70 | MP0002090_abnormal_vision | 0.97971111 |
| 71 | MP0005408_hypopigmentation | 0.97533706 |
| 72 | MP0008875_abnormal_xenobiotic_pharmacok | 0.97485194 |
| 73 | MP0000350_abnormal_cell_proliferation | 0.96096734 |
| 74 | MP0002876_abnormal_thyroid_physiology | 0.93987677 |
| 75 | MP0003787_abnormal_imprinting | 0.93336205 |
| 76 | MP0000653_abnormal_sex_gland | 0.91854934 |
| 77 | MP0002822_catalepsy | 0.91768967 |
| 78 | MP0004924_abnormal_behavior | 0.90906479 |
| 79 | MP0005386_behavior/neurological_phenoty | 0.90906479 |
| 80 | MP0002751_abnormal_autonomic_nervous | 0.89014961 |
| 81 | MP0005391_vision/eye_phenotype | 0.88693261 |
| 82 | MP0005394_taste/olfaction_phenotype | 0.88320352 |
| 83 | MP0005499_abnormal_olfactory_system | 0.88320352 |
| 84 | MP0002734_abnormal_mechanical_nocicepti | 0.87939095 |
| 85 | MP0002132_abnormal_respiratory_system | 0.87914499 |
| 86 | MP0000647_abnormal_sebaceous_gland | 0.87113899 |
| 87 | MP0000372_irregular_coat_pigmentation | 0.86647378 |
| 88 | MP0005171_absent_coat_pigmentation | 0.86166364 |
| 89 | MP0002572_abnormal_emotion/affect_behav | 0.85812735 |
| 90 | MP0001697_abnormal_embryo_size | 0.85313238 |
| 91 | MP0002064_seizures | 0.84767228 |
| 92 | MP0002084_abnormal_developmental_patter | 0.84708549 |
| 93 | MP0005379_endocrine/exocrine_gland_phen | 0.84512332 |
| 94 | MP0002272_abnormal_nervous_system | 0.84378176 |
| 95 | MP0002085_abnormal_embryonic_tissue | 0.84112269 |
| 96 | MP0005376_homeostasis/metabolism_phenot | 0.84085889 |
| 97 | MP0005389_reproductive_system_phenotype | 0.82928487 |
| 98 | MP0001324_abnormal_eye_pigmentation | 0.82706447 |
| 99 | MP0000358_abnormal_cell_content/ | 0.82516299 |
| 100 | MP0009053_abnormal_anal_canal | 0.82372693 |
| 101 | MP0002697_abnormal_eye_size | 0.82236312 |
| 102 | MP0005645_abnormal_hypothalamus_physiol | 0.81963716 |
| 103 | MP0005085_abnormal_gallbladder_physiolo | 0.81750683 |
| 104 | MP0009046_muscle_twitch | 0.80597866 |
| 105 | MP0002837_dystrophic_cardiac_calcinosis | 0.78569210 |
| 106 | MP0001672_abnormal_embryogenesis/_devel | 0.78124772 |
| 107 | MP0005380_embryogenesis_phenotype | 0.78124772 |
| 108 | MP0005187_abnormal_penis_morphology | 0.78087135 |
| 109 | MP0003698_abnormal_male_reproductive | 0.77826377 |
| 110 | MP0001984_abnormal_olfaction | 0.77722367 |
| 111 | MP0004215_abnormal_myocardial_fiber | 0.76366417 |
| 112 | MP0002067_abnormal_sensory_capabilities | 0.74217259 |
| 113 | MP0002163_abnormal_gland_morphology | 0.73616596 |
| 114 | MP0000749_muscle_degeneration | 0.73226200 |
| 115 | MP0002095_abnormal_skin_pigmentation | 0.72454904 |
| 116 | MP0000313_abnormal_cell_death | 0.70669112 |
| 117 | MP0005195_abnormal_posterior_eye | 0.69872810 |
| 118 | MP0002080_prenatal_lethality | 0.69792318 |
| 119 | MP0001485_abnormal_pinna_reflex | 0.69204274 |
| 120 | MP0001542_abnormal_bone_strength | 0.67333565 |
| 121 | MP0000049_abnormal_middle_ear | 0.65949242 |
| 122 | MP0002210_abnormal_sex_determination | 0.62670636 |
| 123 | MP0005332_abnormal_amino_acid | 0.61104129 |
| 124 | MP0002063_abnormal_learning/memory/cond | 0.59281472 |
| 125 | MP0002282_abnormal_trachea_morphology | 0.59096044 |
| 126 | MP0008260_abnormal_autophagy | 0.58372362 |
| 127 | MP0003937_abnormal_limbs/digits/tail_de | 0.57971969 |
| 128 | MP0001919_abnormal_reproductive_system | 0.57709588 |
| 129 | MP0003195_calcinosis | 0.56820149 |
| 130 | MP0003119_abnormal_digestive_system | 0.56164870 |
| 131 | MP0003941_abnormal_skin_development | 0.55640792 |
| 132 | MP0001145_abnormal_male_reproductive | 0.54714821 |
| 133 | MP0000026_abnormal_inner_ear | 0.54636553 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Acute necrotizing encephalopathy (HP:0006965) | 6.34426445 |
| 2 | Abnormal mitochondria in muscle tissue (HP:0008316) | 5.73659046 |
| 3 | Mitochondrial inheritance (HP:0001427) | 5.47154847 |
| 4 | Acute encephalopathy (HP:0006846) | 5.29286679 |
| 5 | Progressive macrocephaly (HP:0004481) | 5.28168408 |
| 6 | Increased serum pyruvate (HP:0003542) | 5.13038427 |
| 7 | Abnormality of glycolysis (HP:0004366) | 5.13038427 |
| 8 | Increased CSF lactate (HP:0002490) | 5.00723973 |
| 9 | Hepatocellular necrosis (HP:0001404) | 4.67351697 |
| 10 | Abnormality of the heme biosynthetic pathway (HP:0010472) | 4.33280169 |
| 11 | Increased hepatocellular lipid droplets (HP:0006565) | 4.16743362 |
| 12 | Hepatic necrosis (HP:0002605) | 4.02097711 |
| 13 | Cerebral edema (HP:0002181) | 3.99924141 |
| 14 | Lipid accumulation in hepatocytes (HP:0006561) | 3.74673076 |
| 15 | Abnormality of cells of the erythroid lineage (HP:0012130) | 3.74007368 |
| 16 | Increased serum lactate (HP:0002151) | 3.64890883 |
| 17 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 3.51700249 |
| 18 | Abnormal number of erythroid precursors (HP:0012131) | 3.50534418 |
| 19 | 3-Methylglutaconic aciduria (HP:0003535) | 3.46018603 |
| 20 | Birth length less than 3rd percentile (HP:0003561) | 3.40280732 |
| 21 | Renal Fanconi syndrome (HP:0001994) | 3.36559370 |
| 22 | Respiratory failure (HP:0002878) | 3.35349315 |
| 23 | Leukodystrophy (HP:0002415) | 3.30523916 |
| 24 | Exercise intolerance (HP:0003546) | 3.28962843 |
| 25 | Lactic acidosis (HP:0003128) | 3.28022342 |
| 26 | Macrocytic anemia (HP:0001972) | 3.18340810 |
| 27 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 3.12569841 |
| 28 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 3.12569841 |
| 29 | Optic disc pallor (HP:0000543) | 3.10410889 |
| 30 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 3.06618711 |
| 31 | Reticulocytopenia (HP:0001896) | 2.90945068 |
| 32 | Breast hypoplasia (HP:0003187) | 2.86441065 |
| 33 | Cerebral hypomyelination (HP:0006808) | 2.76954992 |
| 34 | Increased intramyocellular lipid droplets (HP:0012240) | 2.76200219 |
| 35 | Methylmalonic acidemia (HP:0002912) | 2.67416716 |
| 36 | Type I transferrin isoform profile (HP:0003642) | 2.66547851 |
| 37 | CNS demyelination (HP:0007305) | 2.59955808 |
| 38 | Abnormality of methionine metabolism (HP:0010901) | 2.57179864 |
| 39 | Hyperglycinemia (HP:0002154) | 2.55983042 |
| 40 | Microvesicular hepatic steatosis (HP:0001414) | 2.52080477 |
| 41 | Exertional dyspnea (HP:0002875) | 2.50783443 |
| 42 | Emotional lability (HP:0000712) | 2.47471120 |
| 43 | Delusions (HP:0000746) | 2.44834496 |
| 44 | Congenital nonbullous ichthyosiform erythroderma (HP:0007479) | 2.38449585 |
| 45 | Respiratory difficulties (HP:0002880) | 2.34712414 |
| 46 | Meckel diverticulum (HP:0002245) | 2.34266145 |
| 47 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 2.34078533 |
| 48 | Oral leukoplakia (HP:0002745) | 2.32662228 |
| 49 | Pallor (HP:0000980) | 2.32448947 |
| 50 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 2.30176330 |
| 51 | Lethargy (HP:0001254) | 2.27724451 |
| 52 | Abnormality of serum amino acid levels (HP:0003112) | 2.23162027 |
| 53 | Methylmalonic aciduria (HP:0012120) | 2.23130230 |
| 54 | Abnormality of the labia minora (HP:0012880) | 2.22435617 |
| 55 | Abnormality of the ileum (HP:0001549) | 2.22268402 |
| 56 | Increased muscle lipid content (HP:0009058) | 2.21689367 |
| 57 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.20501593 |
| 58 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.20501593 |
| 59 | Abnormal protein glycosylation (HP:0012346) | 2.20501593 |
| 60 | Abnormal glycosylation (HP:0012345) | 2.20501593 |
| 61 | Neuroendocrine neoplasm (HP:0100634) | 2.19338637 |
| 62 | Hypobetalipoproteinemia (HP:0003563) | 2.18611346 |
| 63 | Degeneration of anterior horn cells (HP:0002398) | 2.17186321 |
| 64 | Abnormality of the anterior horn cell (HP:0006802) | 2.17186321 |
| 65 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 2.16912183 |
| 66 | X-linked dominant inheritance (HP:0001423) | 2.16123098 |
| 67 | Pancreatic cysts (HP:0001737) | 2.15957267 |
| 68 | Hyperalaninemia (HP:0003348) | 2.14234039 |
| 69 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.14234039 |
| 70 | Abnormality of alanine metabolism (HP:0010916) | 2.14234039 |
| 71 | Abnormality of renal resorption (HP:0011038) | 2.11715024 |
| 72 | Chromsome breakage (HP:0040012) | 2.07797276 |
| 73 | Abnormality of placental membranes (HP:0011409) | 2.06789187 |
| 74 | Amniotic constriction ring (HP:0009775) | 2.06789187 |
| 75 | Parakeratosis (HP:0001036) | 2.04546353 |
| 76 | Molar tooth sign on MRI (HP:0002419) | 2.04538924 |
| 77 | Abnormality of midbrain morphology (HP:0002418) | 2.04538924 |
| 78 | Hypoglycemic coma (HP:0001325) | 2.04121413 |
| 79 | True hermaphroditism (HP:0010459) | 1.99397710 |
| 80 | Generalized aminoaciduria (HP:0002909) | 1.99395745 |
| 81 | Rough bone trabeculation (HP:0100670) | 1.98004497 |
| 82 | Ileus (HP:0002595) | 1.95911722 |
| 83 | Abnormal gallbladder physiology (HP:0012438) | 1.95867001 |
| 84 | Cholecystitis (HP:0001082) | 1.95867001 |
| 85 | Glycosuria (HP:0003076) | 1.95752697 |
| 86 | Abnormality of urine glucose concentration (HP:0011016) | 1.95752697 |
| 87 | Reduced antithrombin III activity (HP:0001976) | 1.95235117 |
| 88 | Congenital ichthyosiform erythroderma (HP:0007431) | 1.93700658 |
| 89 | Type 2 muscle fiber atrophy (HP:0003554) | 1.92849017 |
| 90 | Nephronophthisis (HP:0000090) | 1.92094057 |
| 91 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 1.91071715 |
| 92 | Congenital, generalized hypertrichosis (HP:0004540) | 1.89999676 |
| 93 | Supernumerary spleens (HP:0009799) | 1.89353739 |
| 94 | Paralysis (HP:0003470) | 1.88856505 |
| 95 | Abnormality of glycine metabolism (HP:0010895) | 1.88033479 |
| 96 | Abnormality of serine family amino acid metabolism (HP:0010894) | 1.88033479 |
| 97 | Abnormality of chromosome stability (HP:0003220) | 1.87292577 |
| 98 | Stenosis of the external auditory canal (HP:0000402) | 1.86065345 |
| 99 | Autoamputation (HP:0001218) | 1.83478600 |
| 100 | Pheochromocytoma (HP:0002666) | 1.82168626 |
| 101 | Pancreatic islet-cell hyperplasia (HP:0004510) | 1.81409110 |
| 102 | Hyperphosphaturia (HP:0003109) | 1.80505902 |
| 103 | Neoplasm of the adrenal gland (HP:0100631) | 1.80146560 |
| 104 | Abnormality of the preputium (HP:0100587) | 1.79648003 |
| 105 | Hyperglycinuria (HP:0003108) | 1.79476366 |
| 106 | Horseshoe kidney (HP:0000085) | 1.79037464 |
| 107 | CNS hypomyelination (HP:0003429) | 1.78641314 |
| 108 | Abnormality of reticulocytes (HP:0004312) | 1.77639971 |
| 109 | Abnormal lung lobation (HP:0002101) | 1.77127253 |
| 110 | Megaloblastic anemia (HP:0001889) | 1.76874932 |
| 111 | Abnormal pupillary function (HP:0007686) | 1.74918942 |
| 112 | Aplastic anemia (HP:0001915) | 1.73752027 |
| 113 | Nephrogenic diabetes insipidus (HP:0009806) | 1.71831979 |
| 114 | Gait imbalance (HP:0002141) | 1.71815969 |
| 115 | Gliosis (HP:0002171) | 1.70444695 |
| 116 | Postnatal microcephaly (HP:0005484) | 1.70378240 |
| 117 | Ependymoma (HP:0002888) | 1.68822526 |
| 118 | Unsteady gait (HP:0002317) | 1.68698434 |
| 119 | Hypoplastic pelvis (HP:0008839) | 1.68289816 |
| 120 | Medial flaring of the eyebrow (HP:0010747) | 1.67678784 |
| 121 | Cholelithiasis (HP:0001081) | 1.67640211 |
| 122 | Multiple enchondromatosis (HP:0005701) | 1.66982514 |
| 123 | Abnormality of aromatic amino acid family metabolism (HP:0004338) | 1.66124559 |
| 124 | Blindness (HP:0000618) | 1.65199968 |
| 125 | Progressive external ophthalmoplegia (HP:0000590) | 1.64186740 |
| 126 | Abnormal gallbladder morphology (HP:0012437) | 1.60529882 |
| 127 | Secondary amenorrhea (HP:0000869) | 1.59452401 |
| 128 | Spastic paraparesis (HP:0002313) | 1.59402256 |
| 129 | Abnormal trabecular bone morphology (HP:0100671) | 1.58361343 |
| 130 | Poikilocytosis (HP:0004447) | 1.57374272 |
| 131 | Hypothermia (HP:0002045) | 1.53804342 |
| 132 | Colon cancer (HP:0003003) | 1.53023712 |
| 133 | Hypoplasia of the capital femoral epiphysis (HP:0003090) | 1.51401752 |
| 134 | Patellar aplasia (HP:0006443) | 1.51083435 |
| 135 | Female pseudohermaphroditism (HP:0010458) | 1.50732265 |
| 136 | Nausea (HP:0002018) | 1.50186565 |
| 137 | Vomiting (HP:0002013) | 1.49831439 |
| 138 | Poor suck (HP:0002033) | 1.49073645 |
| 139 | Congenital primary aphakia (HP:0007707) | 1.46866344 |
| 140 | Diaphragmatic weakness (HP:0009113) | 1.46560405 |
| 141 | Abnormal hemoglobin (HP:0011902) | 1.46227319 |
| 142 | Pancreatic fibrosis (HP:0100732) | 1.46070153 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | BUB1 | 4.56952897 |
| 2 | EIF2AK1 | 4.31132877 |
| 3 | STK16 | 3.31236136 |
| 4 | WEE1 | 3.00825086 |
| 5 | VRK2 | 2.89580229 |
| 6 | CASK | 2.71538975 |
| 7 | NME1 | 2.69240347 |
| 8 | MST4 | 2.59411194 |
| 9 | PBK | 2.57741446 |
| 10 | NME2 | 2.31111169 |
| 11 | MAP4K2 | 2.25831218 |
| 12 | CDC7 | 2.20781019 |
| 13 | TRIM28 | 2.17360350 |
| 14 | VRK1 | 2.17187019 |
| 15 | SRPK1 | 2.16820161 |
| 16 | TSSK6 | 2.15623909 |
| 17 | WNK3 | 2.13551216 |
| 18 | EIF2AK3 | 2.02825441 |
| 19 | BRSK2 | 1.99394615 |
| 20 | PNCK | 1.97842405 |
| 21 | TLK1 | 1.90649188 |
| 22 | NUAK1 | 1.86286206 |
| 23 | MAP3K12 | 1.85348562 |
| 24 | PLK3 | 1.72880843 |
| 25 | BRSK1 | 1.52623685 |
| 26 | ARAF | 1.46467900 |
| 27 | PLK2 | 1.44094769 |
| 28 | MKNK1 | 1.43900795 |
| 29 | BRAF | 1.42834992 |
| 30 | CCNB1 | 1.42322526 |
| 31 | BCR | 1.40509407 |
| 32 | AURKA | 1.40101824 |
| 33 | PLK4 | 1.38857303 |
| 34 | TNIK | 1.37278031 |
| 35 | PLK1 | 1.32578241 |
| 36 | NEK1 | 1.30622930 |
| 37 | TTK | 1.26653917 |
| 38 | MAP2K7 | 1.21639180 |
| 39 | LIMK1 | 1.15112429 |
| 40 | PDK2 | 1.11851273 |
| 41 | AURKB | 1.05035901 |
| 42 | ERBB3 | 1.04416749 |
| 43 | CSNK1G1 | 1.03779244 |
| 44 | ZAK | 0.99394415 |
| 45 | AKT3 | 0.99293300 |
| 46 | MAP3K4 | 0.91909375 |
| 47 | CSNK1G2 | 0.90736776 |
| 48 | TAF1 | 0.89023530 |
| 49 | PIM2 | 0.88250479 |
| 50 | CDK8 | 0.85925832 |
| 51 | CDK19 | 0.84772178 |
| 52 | CSNK1A1L | 0.83381269 |
| 53 | TESK2 | 0.82954858 |
| 54 | ABL2 | 0.81243677 |
| 55 | FRK | 0.81160108 |
| 56 | DYRK2 | 0.81149848 |
| 57 | GRK1 | 0.80251725 |
| 58 | OXSR1 | 0.79383058 |
| 59 | MYLK | 0.76368088 |
| 60 | MKNK2 | 0.75568947 |
| 61 | CSNK2A1 | 0.74685781 |
| 62 | CSNK2A2 | 0.74374558 |
| 63 | EIF2AK2 | 0.72606336 |
| 64 | FGFR2 | 0.71968145 |
| 65 | STK38L | 0.71131255 |
| 66 | MINK1 | 0.71050549 |
| 67 | STK39 | 0.70419736 |
| 68 | BCKDK | 0.70077472 |
| 69 | ACVR1B | 0.70058689 |
| 70 | GRK5 | 0.69514548 |
| 71 | ADRBK2 | 0.69329258 |
| 72 | GRK7 | 0.67534817 |
| 73 | CHEK2 | 0.66760337 |
| 74 | ADRBK1 | 0.65657775 |
| 75 | OBSCN | 0.63283474 |
| 76 | BMPR2 | 0.62498198 |
| 77 | MAP2K4 | 0.61695317 |
| 78 | EPHA2 | 0.61554732 |
| 79 | WNK4 | 0.61056189 |
| 80 | PDK3 | 0.59324030 |
| 81 | PDK4 | 0.59324030 |
| 82 | DAPK1 | 0.58932245 |
| 83 | CSNK1G3 | 0.57949135 |
| 84 | SIK3 | 0.57650281 |
| 85 | CAMK2B | 0.57166525 |
| 86 | BMPR1B | 0.56690481 |
| 87 | TESK1 | 0.55035165 |
| 88 | RPS6KA4 | 0.54620345 |
| 89 | ATR | 0.53764437 |
| 90 | CDK14 | 0.53211415 |
| 91 | NTRK3 | 0.52133158 |
| 92 | CDK18 | 0.50467375 |
| 93 | STK24 | 0.49956466 |
| 94 | FGFR1 | 0.49887719 |
| 95 | CAMKK2 | 0.49819268 |
| 96 | PASK | 0.49662638 |
| 97 | DYRK3 | 0.48996557 |
| 98 | RPS6KA5 | 0.48615778 |
| 99 | STK4 | 0.48550824 |
| 100 | PINK1 | 0.47269246 |
| 101 | PAK4 | 0.47190812 |
| 102 | INSRR | 0.47020192 |
| 103 | MAPKAPK5 | 0.46923515 |
| 104 | CDK7 | 0.46147917 |
| 105 | CHEK1 | 0.46006941 |
| 106 | PRKCG | 0.45756418 |
| 107 | PIK3CA | 0.45520242 |
| 108 | YES1 | 0.44996337 |
| 109 | MAPK13 | 0.44523127 |
| 110 | STK3 | 0.44154603 |
| 111 | NEK2 | 0.44006714 |
| 112 | MUSK | 0.43774349 |
| 113 | PAK1 | 0.43245994 |
| 114 | CDK15 | 0.42568174 |
| 115 | CAMK2A | 0.42295523 |
| 116 | CDK11A | 0.39714824 |
| 117 | ATM | 0.39484146 |
| 118 | MAP3K11 | 0.38295618 |
| 119 | RPS6KB2 | 0.37641816 |
| 120 | ALK | 0.36077516 |
| 121 | PRKCI | 0.35865483 |
| 122 | MAP3K8 | 0.35111019 |
| 123 | CSNK1E | 0.34977411 |
| 124 | ERBB4 | 0.34405134 |
| 125 | EPHA4 | 0.34109064 |
| 126 | MET | 0.33295370 |
| 127 | CSNK1A1 | 0.32827976 |
| 128 | CDK3 | 0.32758031 |
| 129 | CDK1 | 0.31976101 |
| 130 | ILK | 0.31578632 |
| 131 | PAK3 | 0.28822110 |
| 132 | TGFBR1 | 0.28632094 |
| 133 | PRKCE | 0.27724707 |
| 134 | PRKDC | 0.27014617 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 4.72262831 |
| 2 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 4.36958938 |
| 3 | Ribosome_Homo sapiens_hsa03010 | 3.92725176 |
| 4 | Parkinsons disease_Homo sapiens_hsa05012 | 3.82036237 |
| 5 | RNA polymerase_Homo sapiens_hsa03020 | 3.12715430 |
| 6 | Huntingtons disease_Homo sapiens_hsa05016 | 2.86583592 |
| 7 | DNA replication_Homo sapiens_hsa03030 | 2.81370469 |
| 8 | Alzheimers disease_Homo sapiens_hsa05010 | 2.63978923 |
| 9 | Mismatch repair_Homo sapiens_hsa03430 | 2.55730612 |
| 10 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.32954628 |
| 11 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.15889899 |
| 12 | Protein export_Homo sapiens_hsa03060 | 2.12344847 |
| 13 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 2.08823484 |
| 14 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.05547618 |
| 15 | Spliceosome_Homo sapiens_hsa03040 | 1.99153985 |
| 16 | Caffeine metabolism_Homo sapiens_hsa00232 | 1.94389518 |
| 17 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 1.92814347 |
| 18 | RNA transport_Homo sapiens_hsa03013 | 1.89579863 |
| 19 | Homologous recombination_Homo sapiens_hsa03440 | 1.84284931 |
| 20 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.78547852 |
| 21 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.74965202 |
| 22 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.62561056 |
| 23 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.59474899 |
| 24 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.56057865 |
| 25 | Basal transcription factors_Homo sapiens_hsa03022 | 1.47651095 |
| 26 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.39352848 |
| 27 | Base excision repair_Homo sapiens_hsa03410 | 1.38866257 |
| 28 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.32872058 |
| 29 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.30262043 |
| 30 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.29147444 |
| 31 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.26915007 |
| 32 | Cell cycle_Homo sapiens_hsa04110 | 1.24157506 |
| 33 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.24139800 |
| 34 | Purine metabolism_Homo sapiens_hsa00230 | 1.21591248 |
| 35 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.18425283 |
| 36 | RNA degradation_Homo sapiens_hsa03018 | 1.16479130 |
| 37 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 1.10759458 |
| 38 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.09153534 |
| 39 | Glutathione metabolism_Homo sapiens_hsa00480 | 1.03450440 |
| 40 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.02076379 |
| 41 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.99478368 |
| 42 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.96198298 |
| 43 | Carbon metabolism_Homo sapiens_hsa01200 | 0.96018729 |
| 44 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.93957609 |
| 45 | Metabolic pathways_Homo sapiens_hsa01100 | 0.88404810 |
| 46 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.85763761 |
| 47 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.84179051 |
| 48 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.83131794 |
| 49 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.83100570 |
| 50 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.81489595 |
| 51 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.81055908 |
| 52 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.80673039 |
| 53 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.80661979 |
| 54 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.80395311 |
| 55 | Nicotine addiction_Homo sapiens_hsa05033 | 0.80045669 |
| 56 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.78824206 |
| 57 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.75355572 |
| 58 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.75089775 |
| 59 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.71551104 |
| 60 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.69821382 |
| 61 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.69682258 |
| 62 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.69517964 |
| 63 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.68779432 |
| 64 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.67795769 |
| 65 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.63695899 |
| 66 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.61232557 |
| 67 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.58069628 |
| 68 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.57638433 |
| 69 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.55077413 |
| 70 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.55047916 |
| 71 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.54225983 |
| 72 | Sulfur relay system_Homo sapiens_hsa04122 | 0.52807437 |
| 73 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.50487525 |
| 74 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.50098664 |
| 75 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.49244780 |
| 76 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.48339759 |
| 77 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.48294276 |
| 78 | Peroxisome_Homo sapiens_hsa04146 | 0.48262481 |
| 79 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.47566221 |
| 80 | Histidine metabolism_Homo sapiens_hsa00340 | 0.45685324 |
| 81 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.45549358 |
| 82 | Alcoholism_Homo sapiens_hsa05034 | 0.45242012 |
| 83 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.44666841 |
| 84 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.42664950 |
| 85 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.42369128 |
| 86 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 0.41269507 |
| 87 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.40699743 |
| 88 | Retinol metabolism_Homo sapiens_hsa00830 | 0.35874834 |
| 89 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.35258296 |
| 90 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.34471047 |
| 91 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.34435183 |
| 92 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.34394782 |
| 93 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.32608004 |
| 94 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.32511558 |
| 95 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.32027938 |
| 96 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.31049096 |
| 97 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 0.30968036 |
| 98 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.30655389 |
| 99 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.30255826 |
| 100 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.29650686 |
| 101 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.29069592 |
| 102 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.26697512 |
| 103 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.25264774 |
| 104 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.24512411 |
| 105 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.24404061 |
| 106 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.24308648 |
| 107 | Phototransduction_Homo sapiens_hsa04744 | 0.24001436 |
| 108 | Serotonergic synapse_Homo sapiens_hsa04726 | 0.23339272 |
| 109 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.22719943 |
| 110 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.22405998 |
| 111 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.22191396 |
| 112 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.20935253 |
| 113 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.18387664 |
| 114 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.18158479 |
| 115 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.15397090 |
| 116 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.12850705 |

