ACP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the beta subunit of lysosomal acid phosphatase (LAP). LAP is chemically and genetically distinct from red cell acid phosphatase. The encoded protein belongs to a family of distinct isoenzymes which hydrolyze orthophosphoric monoesters to alcohol and phosphate. LAP-deficiencies in mice cause multiple defects including bone structure alterations, lysosomal storage defects in the kidneys and central nervous system, and an increased tendency towards seizures. An enzymatically-inactive allele of LAP in mice exhibited a more severe phenotype than the null allele, and defects included cerebellum abnormalities, growth retardation, hair-follicle abnormalities, and an ataxia-like phenotype. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by symbiont of host defense response (GO:0052031)4.82494105
2modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.82494105
3modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.82494105
4positive regulation by organism of defense response of other organism involved in symbiotic interact4.82494105
5modulation by symbiont of host immune response (GO:0052553)4.82494105
6positive regulation by symbiont of host defense response (GO:0052509)4.82494105
7glycolipid catabolic process (GO:0019377)4.78851841
8oligosaccharide catabolic process (GO:0009313)4.51601069
9microglial cell activation (GO:0001774)4.49886154
10regulation of mononuclear cell migration (GO:0071675)4.25602787
11barbed-end actin filament capping (GO:0051016)4.14999673
12ceramide catabolic process (GO:0046514)4.14434303
13macrophage activation involved in immune response (GO:0002281)4.08477712
14amino sugar catabolic process (GO:0046348)4.01047232
15membrane lipid catabolic process (GO:0046466)3.74688256
16fat-soluble vitamin biosynthetic process (GO:0042362)3.74221493
17sphingolipid catabolic process (GO:0030149)3.69146071
18apoptotic cell clearance (GO:0043277)3.51372023
19regulation of macrophage chemotaxis (GO:0010758)3.50065547
20negative regulation of interleukin-12 production (GO:0032695)3.45117561
21response to thyroid hormone (GO:0097066)3.43686423
22adhesion of symbiont to host cell (GO:0044650)3.41923189
23virion attachment to host cell (GO:0019062)3.41923189
24response to peptidoglycan (GO:0032494)3.38916150
25positive regulation of lipoprotein lipase activity (GO:0051006)3.38236593
26positive regulation of triglyceride lipase activity (GO:0061365)3.38236593
27protein localization to endosome (GO:0036010)3.28664499
28adhesion of symbiont to host (GO:0044406)3.25753962
29response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.21532864
30response to host immune response (GO:0052572)3.21532864
31positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.18220951
32complement activation, alternative pathway (GO:0006957)3.14348761
33regulation of interferon-beta biosynthetic process (GO:0045357)3.12232293
34N-acetylneuraminate metabolic process (GO:0006054)3.10104050
35triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.08315830
36lipopolysaccharide-mediated signaling pathway (GO:0031663)3.01390688
37response to host (GO:0075136)2.95945374
38response to host defenses (GO:0052200)2.95945374
39response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.95945374
40low-density lipoprotein particle clearance (GO:0034383)2.94313284
41pinocytosis (GO:0006907)2.93039230
42regulation of vitamin D biosynthetic process (GO:0060556)2.91653950
43positive regulation of cholesterol efflux (GO:0010875)2.91016092
44NIK/NF-kappaB signaling (GO:0038061)2.89980759
45macrophage activation (GO:0042116)2.89786425
46angiotensin maturation (GO:0002003)2.89108693
47amyloid precursor protein catabolic process (GO:0042987)2.87735424
48mannose metabolic process (GO:0006013)2.86300353
49negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.84577775
50positive regulation of cellular amide metabolic process (GO:0034250)2.83777409
51peptidyl-glutamic acid carboxylation (GO:0017187)2.82088053
52protein carboxylation (GO:0018214)2.82088053
53regulation of membrane protein ectodomain proteolysis (GO:0051043)2.81587984
54peptide catabolic process (GO:0043171)2.80721746
55erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.78929840
56L-phenylalanine catabolic process (GO:0006559)2.78929840
57positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.76666357
58regulation of vitamin metabolic process (GO:0030656)2.76568474
59myeloid dendritic cell differentiation (GO:0043011)2.75508404
60negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.73958384
61regulation of podosome assembly (GO:0071801)2.73698141
62negative regulation of myeloid cell apoptotic process (GO:0033033)2.72449256
63eosinophil chemotaxis (GO:0048245)2.71833252
64immunoglobulin mediated immune response (GO:0016064)2.68639380
65keratan sulfate catabolic process (GO:0042340)2.63605397
66G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.63472430
67decidualization (GO:0046697)2.63007793
68alpha-linolenic acid metabolic process (GO:0036109)2.62826413
69hyaluronan catabolic process (GO:0030214)2.62732929
70negative regulation of nitric oxide biosynthetic process (GO:0045019)2.62163780
71plasma lipoprotein particle clearance (GO:0034381)2.61839877
72regulation of superoxide anion generation (GO:0032928)2.61366181
73cholesterol efflux (GO:0033344)2.60955013
74cellular response to cadmium ion (GO:0071276)2.57683513
75low-density lipoprotein particle remodeling (GO:0034374)2.56601664
76positive regulation of monocyte chemotaxis (GO:0090026)2.56479422
77positive regulation of extracellular matrix organization (GO:1903055)2.55871959
78monocyte chemotaxis (GO:0002548)2.55795695
79reverse cholesterol transport (GO:0043691)2.55460709
80COPI coating of Golgi vesicle (GO:0048205)2.54436640
81Golgi transport vesicle coating (GO:0048200)2.54436640
82glial cell migration (GO:0008347)2.54072798
83phosphatidylglycerol biosynthetic process (GO:0006655)2.52179748
84regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.51837675
85positive regulation of chemokine biosynthetic process (GO:0045080)2.51039356
86regulation of protein activation cascade (GO:2000257)2.50366440
87positive regulation of leukocyte degranulation (GO:0043302)2.50197125
88regulation of cholesterol homeostasis (GO:2000188)2.47085611
89high-density lipoprotein particle remodeling (GO:0034375)2.46992984
90regulation of cholesterol esterification (GO:0010872)2.46865252
91L-phenylalanine metabolic process (GO:0006558)2.46774232
92erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.46774232
93gamma-aminobutyric acid transport (GO:0015812)2.46668286
94positive regulation of sterol transport (GO:0032373)2.46359234
95positive regulation of cholesterol transport (GO:0032376)2.46359234
96phospholipid efflux (GO:0033700)2.46192467
97positive regulation of fatty acid biosynthetic process (GO:0045723)2.46014281
98protein retention in ER lumen (GO:0006621)2.45629459
99regulation of cytokine secretion involved in immune response (GO:0002739)2.44304098
100regulation of apoptotic cell clearance (GO:2000425)2.44141297
101protein-lipid complex remodeling (GO:0034368)2.41906659
102macromolecular complex remodeling (GO:0034367)2.41906659
103plasma lipoprotein particle remodeling (GO:0034369)2.41906659
104detection of molecule of bacterial origin (GO:0032490)2.41143912
105aromatic amino acid family catabolic process (GO:0009074)2.41001706
106regulation of complement activation (GO:0030449)2.40925001
107negative regulation of cholesterol transport (GO:0032375)2.40037735
108negative regulation of sterol transport (GO:0032372)2.40037735
109vitamin D metabolic process (GO:0042359)2.39568101
110positive regulation of antigen processing and presentation (GO:0002579)2.38550365
111endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.38205854
112eosinophil migration (GO:0072677)2.38015599
113negative regulation of erythrocyte differentiation (GO:0045647)2.37988123
114antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.37761834
115lipoprotein transport (GO:0042953)2.36787220
116regulation of monocyte chemotaxis (GO:0090025)2.35588012
117cellular response to arsenic-containing substance (GO:0071243)2.35546619
118urea cycle (GO:0000050)2.35417061
119urea metabolic process (GO:0019627)2.35417061
120macrophage differentiation (GO:0030225)2.35378430
121glucose 6-phosphate metabolic process (GO:0051156)2.34354957
122bile acid biosynthetic process (GO:0006699)2.33346989
123phospholipid homeostasis (GO:0055091)2.33024064
124L-amino acid import (GO:0043092)2.32756924
125positive regulation of interferon-alpha production (GO:0032727)2.32717753
126regulation of dendritic cell antigen processing and presentation (GO:0002604)2.31710969
127epithelial cell differentiation involved in prostate gland development (GO:0060742)2.30574079
128I-kappaB phosphorylation (GO:0007252)2.28636934
129macroautophagy (GO:0016236)2.28438166
130regulation of early endosome to late endosome transport (GO:2000641)2.27443079
131alanine transport (GO:0032328)2.24927106
132regulation of cholesterol storage (GO:0010885)2.23937966
133G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.22185071
134adenosine receptor signaling pathway (GO:0001973)2.21314081
135positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.21028137
136positive regulation of lipid catabolic process (GO:0050996)2.20425939
137regulation of interferon-alpha production (GO:0032647)2.18453644
138bile acid metabolic process (GO:0008206)2.13133126
139hydrogen peroxide biosynthetic process (GO:0050665)2.12259731
140nitrogen cycle metabolic process (GO:0071941)2.11127279
141tryptophan metabolic process (GO:0006568)2.10764271
142indole-containing compound catabolic process (GO:0042436)2.10429424
143indolalkylamine catabolic process (GO:0046218)2.10429424
144tryptophan catabolic process (GO:0006569)2.10429424
145phagosome maturation (GO:0090382)2.08724857
146positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.07716501
147regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.06326063
148cofactor catabolic process (GO:0051187)2.06276329
149myeloid cell activation involved in immune response (GO:0002275)2.05440363
150dicarboxylic acid biosynthetic process (GO:0043650)2.04917324
151ionotropic glutamate receptor signaling pathway (GO:0035235)2.04515872
152neutrophil activation involved in immune response (GO:0002283)2.04489879
153positive regulation of toll-like receptor signaling pathway (GO:0034123)2.03930534
154plasma lipoprotein particle organization (GO:0071827)2.03779949
155synaptic vesicle maturation (GO:0016188)2.03764950
156negative regulation of fibrinolysis (GO:0051918)2.03688601
157T-helper 1 type immune response (GO:0042088)2.03468452
158regulation of beta-amyloid formation (GO:1902003)2.03293320
159tyrosine metabolic process (GO:0006570)2.02558453
160complement activation (GO:0006956)2.01836293
161respiratory burst (GO:0045730)2.01429001
162homocysteine metabolic process (GO:0050667)2.00616103
163regulation of fibrinolysis (GO:0051917)2.00515942
164regulation of cellular amide metabolic process (GO:0034248)1.99389348
165fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)1.97886626
166kynurenine metabolic process (GO:0070189)1.97504996
167glutamate metabolic process (GO:0006536)1.97394422
168regulation of triglyceride catabolic process (GO:0010896)1.97331812
169nucleobase catabolic process (GO:0046113)1.96578307
170basic amino acid transport (GO:0015802)1.95890034
171protein-lipid complex subunit organization (GO:0071825)1.95378398
172regulation of short-term neuronal synaptic plasticity (GO:0048172)1.95124141
173cellular response to thyroid hormone stimulus (GO:0097067)1.94656387
174glycosphingolipid catabolic process (GO:0046479)1.94374820
175plasma lipoprotein particle assembly (GO:0034377)1.93567253
176amino acid import (GO:0043090)1.93350066
177cellular modified amino acid catabolic process (GO:0042219)1.92220026

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human3.81724402
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.86107911
3RARG_19884340_ChIP-ChIP_MEFs_Mouse2.77405322
4EZH2_22144423_ChIP-Seq_EOC_Human2.77199362
5LXR_22292898_ChIP-Seq_THP-1_Human2.69913175
6GBX2_23144817_ChIP-Seq_PC3_Human2.46909712
7RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.42496275
8IRF8_21731497_ChIP-ChIP_J774_Mouse2.37755753
9TP63_17297297_ChIP-ChIP_HaCaT_Human2.28015927
10ELK3_25401928_ChIP-Seq_HUVEC_Human2.24446037
11VDR_21846776_ChIP-Seq_THP-1_Human2.24114654
12RXR_22158963_ChIP-Seq_LIVER_Mouse2.19609470
13LXR_22158963_ChIP-Seq_LIVER_Mouse2.10113881
14Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.98421918
15FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.92415048
16NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.89020680
17TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.88589643
18TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.87611654
19SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.86435217
20SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.84855067
21IRF8_27001747_Chip-Seq_BMDM_Mouse1.83039620
22KDM2B_26808549_Chip-Seq_SUP-B15_Human1.79740183
23SRY_22984422_ChIP-ChIP_TESTIS_Rat1.79256900
24RACK7_27058665_Chip-Seq_MCF-7_Human1.77528792
25* IRF8_22096565_ChIP-ChIP_GC-B_Human1.76946758
26VDR_24763502_ChIP-Seq_THP-1_Human1.76592017
27SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.72727712
28TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.71275110
29GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.70239233
30PPARA_22158963_ChIP-Seq_LIVER_Mouse1.67066272
31DROSHA_22980978_ChIP-Seq_HELA_Human1.66658564
32SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.66493672
33CLOCK_20551151_ChIP-Seq_293T_Human1.66011325
34CDX2_19796622_ChIP-Seq_MESCs_Mouse1.65814017
35* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.63939253
36SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.63340430
37MTF2_20144788_ChIP-Seq_MESCs_Mouse1.61175859
38MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.60789235
39BRD4_27068464_Chip-Seq_AML-cells_Mouse1.58152342
40RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.58055354
41MYB_21317192_ChIP-Seq_ERMYB_Mouse1.57170764
42EZH2_18974828_ChIP-Seq_MESCs_Mouse1.56536580
43RNF2_18974828_ChIP-Seq_MESCs_Mouse1.56536580
44STAT6_21828071_ChIP-Seq_BEAS2B_Human1.56337175
45SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.56319636
46TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.53965923
47IKZF1_21737484_ChIP-ChIP_HCT116_Human1.53857166
48SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.48253730
49VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.47283601
50JARID2_20064375_ChIP-Seq_MESCs_Mouse1.47174015
51CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.46774797
52KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.46311977
53THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.46100053
54PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.45145948
55EGR1_23403033_ChIP-Seq_LIVER_Mouse1.42351648
56* IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.41937618
57CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.41567275
58STAT4_19710469_ChIP-ChIP_TH1__Mouse1.40966108
59SPI1_23127762_ChIP-Seq_K562_Human1.40883226
60NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.40647522
61JARID2_20075857_ChIP-Seq_MESCs_Mouse1.39582877
62TAF15_26573619_Chip-Seq_HEK293_Human1.39545213
63PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.38674579
64KDM2B_26808549_Chip-Seq_DND41_Human1.37107568
65PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.37037354
66ZNF263_19887448_ChIP-Seq_K562_Human1.36619031
67BP1_19119308_ChIP-ChIP_Hs578T_Human1.35852134
68EED_16625203_ChIP-ChIP_MESCs_Mouse1.35717262
69TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.35469028
70GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.34107379
71NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.33168564
72NRF2_20460467_ChIP-Seq_MEFs_Mouse1.33168564
73KDM2B_26808549_Chip-Seq_K562_Human1.32231584
74NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.31824656
75RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.31491157
76UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.28199897
77REST_21632747_ChIP-Seq_MESCs_Mouse1.26451404
78CTCF_27219007_Chip-Seq_ERYTHROID_Human1.26128065
79PIAS1_25552417_ChIP-Seq_VCAP_Human1.25782929
80TET1_21451524_ChIP-Seq_MESCs_Mouse1.24282173
81RUNX1_22412390_ChIP-Seq_EML_Mouse1.24181561
82BCOR_27268052_Chip-Seq_Bcells_Human1.24132121
83BCL6_27268052_Chip-Seq_Bcells_Human1.24049357
84CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.23201985
85GATA1_19941827_ChIP-Seq_MEL_Mouse1.21831004
86ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.21818163
87SUZ12_27294783_Chip-Seq_ESCs_Mouse1.21516363
88ZFP57_27257070_Chip-Seq_ESCs_Mouse1.21283533
89SMAD4_21799915_ChIP-Seq_A2780_Human1.21257213
90NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.20135088
91EZH2_27294783_Chip-Seq_ESCs_Mouse1.19952465
92P300_19829295_ChIP-Seq_ESCs_Human1.19936687
93TCF7_22412390_ChIP-Seq_EML_Mouse1.19475731
94P68_20966046_ChIP-Seq_HELA_Human1.19043519
95BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.18672366
96MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.18547095
97ZNF217_24962896_ChIP-Seq_MCF-7_Human1.18293650
98SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.18239457
99SA1_27219007_Chip-Seq_ERYTHROID_Human1.18222036
100E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.18154640
101SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.17157473
102PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.17146413
103RNF2_27304074_Chip-Seq_ESCs_Mouse1.17092316
104KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.16198574
105MAF_26560356_Chip-Seq_TH1_Human1.14111600
106ELF1_20517297_ChIP-Seq_JURKAT_Human1.13244352
107KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.12673990
108SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.12458992
109TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.11771947
110VDR_24787735_ChIP-Seq_THP-1_Human1.11225745
111EGR1_19374776_ChIP-ChIP_THP-1_Human1.10762006
112NR3C1_23031785_ChIP-Seq_PC12_Mouse1.09761697
113* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.09560225
114ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.09516190
115ARNT_22903824_ChIP-Seq_MCF-7_Human1.09384996
116* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.09130384
117SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.08912531
118MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.08269279
119EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.08060724
120* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.07946378
121SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.07653749
122GATA1_22383799_ChIP-Seq_G1ME_Mouse1.06820055
123* SMC4_20622854_ChIP-Seq_HELA_Human1.06554389
124ESR1_21235772_ChIP-Seq_MCF-7_Human1.06308521
125P300_27058665_Chip-Seq_ZR-75-30cells_Human1.05962930
126CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.05076570
127AHR_22903824_ChIP-Seq_MCF-7_Human1.04795491
128EZH2_27304074_Chip-Seq_ESCs_Mouse1.04552187
129TFEB_21752829_ChIP-Seq_HELA_Human1.04020540
130PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.03535035
131AR_21572438_ChIP-Seq_LNCaP_Human1.02349538
132SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01860706
133* SMAD3_21741376_ChIP-Seq_EPCs_Human1.01734139
134NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.01319990
135BCAT_22108803_ChIP-Seq_LS180_Human1.00836135
136AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.00579635
137KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.00544160
138SMAD_19615063_ChIP-ChIP_OVARY_Human1.00213812
139SPI1_23547873_ChIP-Seq_NB4_Human0.99082909
140AR_25329375_ChIP-Seq_VCAP_Human0.98940862
141CTBP2_25329375_ChIP-Seq_LNCAP_Human0.98422386
142* FOXA2_19822575_ChIP-Seq_HepG2_Human0.97052006
143TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.95991539
144* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.95917340
145GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.95415545
146SA1_27219007_Chip-Seq_Bcells_Human0.95383962
147TP53_18474530_ChIP-ChIP_U2OS_Human0.95336730
148* CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.95194292
149CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95101914
150TP53_22127205_ChIP-Seq_IMR90_Human0.95064137
151LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.94940969
152CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.94354361
153SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94059008
154RXR_22108803_ChIP-Seq_LS180_Human0.93890525
155SOX2_21211035_ChIP-Seq_LN229_Gbm0.93624753
156PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.92823057
157CTBP1_25329375_ChIP-Seq_LNCAP_Human0.92787026
158NR3C1_21868756_ChIP-Seq_MCF10A_Human0.91875863
159IGF1R_20145208_ChIP-Seq_DFB_Human0.91618715
160REST_18959480_ChIP-ChIP_MESCs_Mouse0.91560734
161TOP2B_26459242_ChIP-Seq_MCF-7_Human0.91245656
162STAT3_23295773_ChIP-Seq_U87_Human0.89578211
163RARB_27405468_Chip-Seq_BRAIN_Mouse0.88311671
164TRIM28_21343339_ChIP-Seq_HEK293_Human0.87896393
165WT1_25993318_ChIP-Seq_PODOCYTE_Human0.87839966
166TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.87751295
167POU3F2_20337985_ChIP-ChIP_501MEL_Human0.86129313
168OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.85863124
169ESR1_20079471_ChIP-ChIP_T-47D_Human0.85786067
170ERG_21242973_ChIP-ChIP_JURKAT_Human0.85684947
171GATA1_22025678_ChIP-Seq_K562_Human0.83201253
172TCF4_22108803_ChIP-Seq_LS180_Human0.82900059
173RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.82723649
174RUNX2_22187159_ChIP-Seq_PCA_Human0.81763257
175GATA2_21666600_ChIP-Seq_HMVEC_Human0.80229655
176ESR2_21235772_ChIP-Seq_MCF-7_Human0.80180692
177TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.79871158
178SMAD4_21741376_ChIP-Seq_HESCs_Human0.79760667
179PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.78401357

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system3.86538584
2MP0003191_abnormal_cellular_cholesterol3.13056578
3* MP0005058_abnormal_lysosome_morphology3.02142876
4MP0005360_urolithiasis3.01141504
5MP0003172_abnormal_lysosome_physiology2.91840050
6MP0009840_abnormal_foam_cell2.80989147
7MP0003690_abnormal_glial_cell2.73424500
8MP0005085_abnormal_gallbladder_physiolo2.65086278
9MP0004859_abnormal_synaptic_plasticity2.55963068
10MP0005365_abnormal_bile_salt2.51307545
11MP0006082_CNS_inflammation2.40584854
12MP0000604_amyloidosis2.35272631
13MP0003252_abnormal_bile_duct2.19162004
14MP0005451_abnormal_body_composition2.18085236
15MP0003300_gastrointestinal_ulcer2.12805885
16MP0008875_abnormal_xenobiotic_pharmacok2.09003611
17MP0004858_abnormal_nervous_system2.05150343
18MP0003195_calcinosis2.03404640
19MP0003075_altered_response_to1.92264282
20MP0003806_abnormal_nucleotide_metabolis1.87260529
21MP0010329_abnormal_lipoprotein_level1.87080463
22MP0001984_abnormal_olfaction1.86933252
23MP0003303_peritoneal_inflammation1.85431304
24MP0003183_abnormal_peptide_metabolism1.83303745
25MP0000569_abnormal_digit_pigmentation1.69229059
26MP0003635_abnormal_synaptic_transmissio1.68212817
27* MP0002064_seizures1.67687508
28MP0003453_abnormal_keratinocyte_physiol1.65170809
29MP0003705_abnormal_hypodermis_morpholog1.64696351
30MP0001501_abnormal_sleep_pattern1.63620967
31MP0009278_abnormal_bone_marrow1.60508627
32MP0005083_abnormal_biliary_tract1.59979648
33MP0002419_abnormal_innate_immunity1.58428737
34MP0003329_amyloid_beta_deposits1.55699392
35MP0005167_abnormal_blood-brain_barrier1.53146519
36MP0000858_altered_metastatic_potential1.48974784
37MP0001853_heart_inflammation1.48366886
38MP0009780_abnormal_chondrocyte_physiolo1.47440028
39MP0003724_increased_susceptibility_to1.46495857
40MP0009745_abnormal_behavioral_response1.45159261
41MP0003436_decreased_susceptibility_to1.44054182
42MP0001968_abnormal_touch/_nociception1.43629625
43MP0009046_muscle_twitch1.42920929
44MP0000685_abnormal_immune_system1.38675466
45MP0003448_altered_tumor_morphology1.37426468
46MP0002063_abnormal_learning/memory/cond1.36952377
47MP0008260_abnormal_autophagy1.36222840
48MP0004510_myositis1.36141207
49MP0003880_abnormal_central_pattern1.34991448
50MP0002736_abnormal_nociception_after1.34582518
51MP0009764_decreased_sensitivity_to1.33880938
52MP0002090_abnormal_vision1.33310706
53MP0004947_skin_inflammation1.32923945
54MP0001845_abnormal_inflammatory_respons1.32451788
55MP0001849_ear_inflammation1.32085495
56MP0002452_abnormal_antigen_presenting1.29500427
57MP0005166_decreased_susceptibility_to1.29267431
58MP0003279_aneurysm1.29124584
59MP0001835_abnormal_antigen_presentation1.28897432
60MP0003633_abnormal_nervous_system1.28041065
61MP0002118_abnormal_lipid_homeostasis1.26457140
62MP0004270_analgesia1.25006894
63MP0005535_abnormal_body_temperature1.24326454
64MP0005464_abnormal_platelet_physiology1.24247241
65MP0005671_abnormal_response_to1.23676547
66MP0002572_abnormal_emotion/affect_behav1.23124384
67MP0006054_spinal_hemorrhage1.22922856
68MP0010155_abnormal_intestine_physiology1.22683012
69MP0005332_abnormal_amino_acid1.21971068
70MP0003091_abnormal_cell_migration1.20976068
71MP0001533_abnormal_skeleton_physiology1.20166592
72MP0010386_abnormal_urinary_bladder1.16912706
73MP0002909_abnormal_adrenal_gland1.16032093
74MP0000920_abnormal_myelination1.14742578
75MP0002723_abnormal_immune_serum1.14705890
76MP0005023_abnormal_wound_healing1.14425045
77MP0008469_abnormal_protein_level1.06555059
78MP0005165_increased_susceptibility_to1.04592095
79MP0004130_abnormal_muscle_cell1.04297644
80MP0005397_hematopoietic_system_phenotyp1.03924216
81MP0001545_abnormal_hematopoietic_system1.03924216
82MP0001486_abnormal_startle_reflex1.03751125
83MP0000609_abnormal_liver_physiology1.03630530
84MP0005164_abnormal_response_to1.02977757
85MP0002877_abnormal_melanocyte_morpholog1.02289810
86* MP0003634_abnormal_glial_cell1.01361880
87MP0003828_pulmonary_edema1.00997765
88MP0005584_abnormal_enzyme/coenzyme_acti1.00930738
89MP0002735_abnormal_chemical_nociception1.00820228
90MP0002998_abnormal_bone_remodeling0.99749221
91MP0001440_abnormal_grooming_behavior0.99045167
92MP0005646_abnormal_pituitary_gland0.98852355
93MP0001666_abnormal_nutrient_absorption0.98303445
94MP0002733_abnormal_thermal_nociception0.96988333
95MP0002734_abnormal_mechanical_nocicepti0.96553642
96MP0001542_abnormal_bone_strength0.96056654
97MP0002148_abnormal_hypersensitivity_rea0.95954196
98MP0009333_abnormal_splenocyte_physiolog0.95054255
99MP0003566_abnormal_cell_adhesion0.94918875
100MP0004883_abnormal_blood_vessel0.94913287
101MP0005310_abnormal_salivary_gland0.94820896
102MP0003656_abnormal_erythrocyte_physiolo0.94535188
103MP0003631_nervous_system_phenotype0.94115922
104MP0009785_altered_susceptibility_to0.94102288
105MP0002067_abnormal_sensory_capabilities0.93805009
106MP0002405_respiratory_system_inflammati0.93515745
107MP0005257_abnormal_intraocular_pressure0.92011785
108MP0005319_abnormal_enzyme/_coenzyme0.91451388
109MP0003879_abnormal_hair_cell0.90627998
110MP0001819_abnormal_immune_cell0.90404494
111MP0005000_abnormal_immune_tolerance0.89001579
112MP0002420_abnormal_adaptive_immunity0.88916613
113MP0001800_abnormal_humoral_immune0.88558900
114MP0002272_abnormal_nervous_system0.87056303
115MP0002876_abnormal_thyroid_physiology0.86849224
116MP0008874_decreased_physiological_sensi0.86322700
117MP0005025_abnormal_response_to0.86037939
118MP0005390_skeleton_phenotype0.85458028
119MP0004782_abnormal_surfactant_physiolog0.85156502
120MP0008004_abnormal_stomach_pH0.83684091
121MP0000343_altered_response_to0.82136229
122MP0004019_abnormal_vitamin_homeostasis0.81316522
123MP0001970_abnormal_pain_threshold0.81282657
124MP0000249_abnormal_blood_vessel0.79203134
125* MP0002896_abnormal_bone_mineralization0.78821183
126MP0003045_fibrosis0.78558618
127* MP0003795_abnormal_bone_structure0.77975520
128MP0002254_reproductive_system_inflammat0.77907397
129MP0001958_emphysema0.75790557
130MP0002138_abnormal_hepatobiliary_system0.75774055
131MP0006276_abnormal_autonomic_nervous0.74567764
132MP0001502_abnormal_circadian_rhythm0.74396386
133MP0005595_abnormal_vascular_smooth0.73372818
134MP0002557_abnormal_social/conspecific_i0.72909104
135MP0009763_increased_sensitivity_to0.72656801
136MP0002229_neurodegeneration0.72552786
137MP0003632_abnormal_nervous_system0.71261466
138MP0008438_abnormal_cutaneous_collagen0.70005346
139MP0001790_abnormal_immune_system0.68561179
140MP0005387_immune_system_phenotype0.68561179
141MP0002078_abnormal_glucose_homeostasis0.68355255
142MP0002277_abnormal_respiratory_mucosa0.68185843
143MP0004924_abnormal_behavior0.66584437
144MP0002933_joint_inflammation0.65307291
145MP0004185_abnormal_adipocyte_glucose0.63005580

Predicted human phenotypes

RankGene SetZ-score
1Systemic lupus erythematosus (HP:0002725)5.85327779
2Complement deficiency (HP:0004431)5.24681304
3Glomerulonephritis (HP:0000099)4.85307038
4Increased cerebral lipofuscin (HP:0011813)4.55541242
5Recurrent gram-negative bacterial infections (HP:0005420)4.47334938
6Abnormality of complement system (HP:0005339)4.07337962
7Increased neuronal autofluorescent lipopigment (HP:0002074)4.05961671
8Abnormality of glycolipid metabolism (HP:0010969)3.86338282
9Abnormality of liposaccharide metabolism (HP:0010968)3.86338282
10Abnormality of glycosphingolipid metabolism (HP:0004343)3.86338282
11Recurrent abscess formation (HP:0002722)3.55250515
12Recurrent bacterial skin infections (HP:0005406)3.54552946
13Vacuolated lymphocytes (HP:0001922)3.50050577
14Deep venous thrombosis (HP:0002625)3.32672331
15Nuclear cataract (HP:0100018)3.27254704
16Dysostosis multiplex (HP:0000943)3.21770068
17Neurofibrillary tangles (HP:0002185)3.16406805
18Joint hemorrhage (HP:0005261)3.10505609
19Xanthomatosis (HP:0000991)3.07798190
20Vertebral compression fractures (HP:0002953)3.06703623
21Amyloidosis (HP:0011034)2.99783217
22Prolonged partial thromboplastin time (HP:0003645)2.94361706
23Purpura (HP:0000979)2.93822377
24Abnormality of mucopolysaccharide metabolism (HP:0011020)2.93225354
25Abnormality of polysaccharide metabolism (HP:0011012)2.93225354
26Abnormality of glycosaminoglycan metabolism (HP:0004371)2.93225354
27Eczematoid dermatitis (HP:0000976)2.92854203
28Supranuclear gaze palsy (HP:0000605)2.92329918
29Abnormality of aromatic amino acid family metabolism (HP:0004338)2.87573167
30Axonal loss (HP:0003447)2.87307807
31Mucopolysacchariduria (HP:0008155)2.85419489
32Urinary glycosaminoglycan excretion (HP:0003541)2.85419489
33Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.84186841
34Hyperlipoproteinemia (HP:0010980)2.83920186
35Focal motor seizures (HP:0011153)2.80551903
36Nephritis (HP:0000123)2.77243587
37Apathy (HP:0000741)2.69987214
38Retinal atrophy (HP:0001105)2.68350102
39Diminished motivation (HP:0000745)2.68216457
40Myocardial infarction (HP:0001658)2.67364740
41Abnormality of macrophages (HP:0004311)2.56476448
42Abnormality of the common coagulation pathway (HP:0010990)2.53887075
43Epidermoid cyst (HP:0200040)2.50589171
44Progressive neurologic deterioration (HP:0002344)2.48782980
45Cerebral inclusion bodies (HP:0100314)2.48341692
46Intrahepatic cholestasis (HP:0001406)2.43242726
47Thin bony cortex (HP:0002753)2.42420361
48Prolonged neonatal jaundice (HP:0006579)2.39883332
49Mitral stenosis (HP:0001718)2.37958900
50Increased serum ferritin (HP:0003281)2.37852096
51Skin nodule (HP:0200036)2.36228930
52Upper motor neuron abnormality (HP:0002127)2.32631099
53Focal seizures (HP:0007359)2.32355147
54Asymmetric septal hypertrophy (HP:0001670)2.31518807
55Malnutrition (HP:0004395)2.30771021
56Bone pain (HP:0002653)2.30029057
57Neuronal loss in central nervous system (HP:0002529)2.28070015
58Mutism (HP:0002300)2.27705783
59Atonic seizures (HP:0010819)2.26630888
60Metaphyseal irregularity (HP:0003025)2.25343887
61Conjugated hyperbilirubinemia (HP:0002908)2.25048163
62Hypercholesterolemia (HP:0003124)2.24120221
63Status epilepticus (HP:0002133)2.22255371
64Generalized tonic-clonic seizures (HP:0002069)2.18480708
65Hypoalphalipoproteinemia (HP:0003233)2.17453701
66Abnormality of the vasculature of the conjunctiva (HP:0008054)2.15287012
67Absence seizures (HP:0002121)2.11191807
68Abnormality of monocarboxylic acid metabolism (HP:0010996)2.10667461
69Hemorrhage of the eye (HP:0011885)2.09384867
70Gingivitis (HP:0000230)2.09085002
71Blue irides (HP:0000635)2.08499982
72Febrile seizures (HP:0002373)2.08093137
73Protuberant abdomen (HP:0001538)2.07950267
74Turricephaly (HP:0000262)2.07292292
75Interstitial pulmonary disease (HP:0006530)2.05929111
76Abnormality of glutamine family amino acid metabolism (HP:0010902)2.05001884
77Loss of speech (HP:0002371)2.04229393
78Hepatosplenomegaly (HP:0001433)2.03318734
79Ketosis (HP:0001946)2.02879302
80Recurrent skin infections (HP:0001581)2.02777686
81Thoracic kyphosis (HP:0002942)2.02394177
82Joint stiffness (HP:0001387)2.00049184
83Clumsiness (HP:0002312)1.98885963
84Hyperventilation (HP:0002883)1.98787443
85Premature rupture of membranes (HP:0001788)1.98473206
86Dialeptic seizures (HP:0011146)1.96510984
87J-shaped sella turcica (HP:0002680)1.95782315
88Achilles tendon contracture (HP:0001771)1.95249539
89Thick nail (HP:0001805)1.95147718
90Epileptic encephalopathy (HP:0200134)1.94383051
91Abnormality of the Achilles tendon (HP:0005109)1.93498714
92Personality changes (HP:0000751)1.92764793
93Cardiomegaly (HP:0001640)1.92589617
94Action tremor (HP:0002345)1.91377596
95Hypophosphatemia (HP:0002148)1.86898901
96Visual hallucinations (HP:0002367)1.86747882
97Progressive visual loss (HP:0000529)1.86331450
98Cervical subluxation (HP:0003308)1.86044365
99Diplopia (HP:0000651)1.85656053
100Abnormality of binocular vision (HP:0011514)1.85656053
101Arterial tortuosity (HP:0005116)1.85599959
102Hypolipoproteinemia (HP:0010981)1.83545980
103Autoimmune thrombocytopenia (HP:0001973)1.82505444
104Upper limb amyotrophy (HP:0009129)1.82453447
105Distal upper limb amyotrophy (HP:0007149)1.82453447
106Mesangial abnormality (HP:0001966)1.81386118
107Hypobetalipoproteinemia (HP:0003563)1.80676499
108Elevated alkaline phosphatase (HP:0003155)1.80363533
109Peripheral demyelination (HP:0011096)1.79844545
110Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.79435737
111Sensorimotor neuropathy (HP:0007141)1.79127185
112Petechiae (HP:0000967)1.77525872
113Global brain atrophy (HP:0002283)1.77410737
114Abnormality of iron homeostasis (HP:0011031)1.77244794
115Agitation (HP:0000713)1.74043017
116Excessive salivation (HP:0003781)1.73602960
117Drooling (HP:0002307)1.73602960
118Myokymia (HP:0002411)1.71796154
119Polyphagia (HP:0002591)1.71421744
120Gingival bleeding (HP:0000225)1.70844350
121Distal lower limb muscle weakness (HP:0009053)1.70809913
122Chronic obstructive pulmonary disease (HP:0006510)1.70358101
123Obstructive lung disease (HP:0006536)1.70358101
124Ovoid vertebral bodies (HP:0003300)1.69994977
125Orchitis (HP:0100796)1.69102627
126Hyperparathyroidism (HP:0000843)1.68741739
127Fair hair (HP:0002286)1.68443500
128Disinhibition (HP:0000734)1.68068720
129Ketoacidosis (HP:0001993)1.67586491
130Cerebral aneurysm (HP:0004944)1.66434331
131Nausea (HP:0002018)1.65448270
132Zonular cataract (HP:0010920)1.65316870
133Pathologic fracture (HP:0002756)1.64656805
134Abnormality of the nasal mucosa (HP:0000433)1.64414434
135Torticollis (HP:0000473)1.61998017
136Vascular tortuosity (HP:0004948)1.61675242
137Abnormality of the thoracic spine (HP:0100711)1.60494702
138Mediastinal lymphadenopathy (HP:0100721)1.60409678
139Abnormality of the periventricular white matter (HP:0002518)1.60363163
140Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.59594820
141Myositis (HP:0100614)1.59306247
142Abnormality of alkaline phosphatase activity (HP:0004379)1.58895087
143Dementia (HP:0000726)1.58716063
144Abnormal eating behavior (HP:0100738)1.58555778
145Abnormality of sulfur amino acid metabolism (HP:0004339)1.58499186
146Spontaneous abortion (HP:0005268)1.58405026
147Hand muscle atrophy (HP:0009130)1.58060617
148Progressive cerebellar ataxia (HP:0002073)1.57905602
149Abnormal enzyme/coenzyme activity (HP:0012379)1.57224293

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME23.69351848
2RIPK43.12534424
3TESK12.90964005
4DDR22.62206370
5TESK22.54414048
6MAP3K112.38726540
7TAOK22.32722433
8NTRK32.19834579
9MAP2K42.13913845
10CAMK1G2.06178386
11MAP3K92.05249146
12EPHA41.99376536
13PIM21.90217095
14BLK1.89370841
15INSRR1.82220955
16IRAK41.75660511
17LIMK11.73385237
18ERN11.72831169
19TAOK31.72098834
20MAP3K141.67097383
21MAP3K31.66613457
22TYK21.63681509
23DAPK21.62062372
24MAP3K41.60072378
25TAOK11.59962810
26JAK11.54932013
27CDC42BPA1.54175049
28CAMK1D1.51751266
29MAP2K71.50803728
30FES1.49622243
31EPHB21.48438609
32TGFBR21.47117092
33FGR1.45065034
34PRPF4B1.43278294
35CASK1.42843904
36PAK41.42251089
37MINK11.41348120
38RIPK11.35080282
39PDGFRA1.30953598
40GRK71.29946482
41MAP3K131.27646254
42NTRK11.26501952
43BMPR21.26354127
44ICK1.24186992
45TBK11.23641466
46MAP2K31.23604414
47EPHB11.22432120
48MARK11.20638378
49IRAK21.16172472
50MOS1.15606665
51IRAK31.12052388
52NEK91.11654784
53KIT1.10648181
54SIK21.10423698
55PAK61.09268702
56TXK1.06547023
57TTN1.06371568
58CAMKK11.06312711
59KSR20.97913760
60PLK20.97398654
61IKBKE0.96911322
62MAP3K60.96235920
63EPHA20.96234478
64SIK10.94814953
65CAMKK20.94349882
66SGK30.92588639
67MAP3K10.91909556
68SGK20.91241878
69PDPK10.91161383
70CSK0.85561488
71MAP4K10.81778753
72HCK0.81750287
73PRKCH0.81395265
74SGK2230.80770844
75SGK4940.80770844
76CSF1R0.80767074
77NTRK20.80411346
78JAK20.80089310
79SMG10.79586351
80IKBKB0.79255063
81JAK30.78801830
82FGFR40.78592344
83MATK0.78295090
84MAPK120.77133132
85SIK30.76018514
86PRKCE0.74928733
87BMX0.74217815
88IRAK10.72193492
89CDK50.72118101
90PHKG20.71443909
91PHKG10.71443909
92TRIB30.71245553
93PDK10.70818814
94FYN0.70048151
95MAP3K120.69944027
96PRKCG0.69287574
97PRKG20.68698822
98MAP3K20.67219383
99PRKAA20.67106226
100MST1R0.66888145
101RET0.66210812
102MAPK150.65937742
103PKN10.65368195
104EPHA30.63690502
105TYRO30.62585506
106EGFR0.62073557
107ZAP700.61975213
108ERBB30.61874465
109SGK10.61848789
110MAP3K50.61657330
111LATS20.60123771
112PRKCZ0.59857167
113PKN20.59266137
114ARAF0.59214896
115DAPK30.58898266
116MAPK70.58582760
117PNCK0.56449893
118STK380.54967747
119ERBB40.54879633
120BCKDK0.54599917
121CAMK2A0.53765670
122LYN0.52967147
123PAK30.52755059
124PDK20.52686941
125KSR10.51617010
126PTK60.51165068
127MAPKAPK30.50955351
128ACVR1B0.50797770
129RPS6KC10.50312233
130RPS6KL10.50312233
131MARK20.49986446
132ABL20.49628753
133FGFR30.49413457
134IGF1R0.48203183
135ADRBK20.48107877
136KDR0.47917426
137PRKG10.47712356
138MAP2K60.47572206
139SYK0.47565074
140RPS6KA20.47230267
141CDK60.47059356
142CHUK0.46916028
143PRKD20.46170809
144GRK50.45847918
145NEK60.44499250
146CAMK40.44216435
147LMTK20.43745754
148PTK20.42974426
149CAMK2G0.41557853
150DYRK1B0.40715674
151MAP3K80.39890822
152MAPK40.38668537
153MAPK110.36389656
154PDGFRB0.33920251
155CDK150.33796753
156CDK140.32407647
157SRC0.31782306
158RPS6KA60.30588942
159PAK10.30587187

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051503.39092742
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.84454922
3Nitrogen metabolism_Homo sapiens_hsa009102.64439984
4Primary bile acid biosynthesis_Homo sapiens_hsa001202.32354619
5Complement and coagulation cascades_Homo sapiens_hsa046102.19350991
6* Lysosome_Homo sapiens_hsa041421.78633156
7Arginine biosynthesis_Homo sapiens_hsa002201.74776202
8Glycosaminoglycan degradation_Homo sapiens_hsa005311.69356354
9Galactose metabolism_Homo sapiens_hsa000521.52263741
10Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.48788764
11Fructose and mannose metabolism_Homo sapiens_hsa000511.44862719
12Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.42493332
13Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.37659088
14Olfactory transduction_Homo sapiens_hsa047401.36400417
15Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.36230134
16Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.35689326
17Prion diseases_Homo sapiens_hsa050201.35336662
18Synaptic vesicle cycle_Homo sapiens_hsa047211.32833975
19Asthma_Homo sapiens_hsa053101.26860510
20Other glycan degradation_Homo sapiens_hsa005111.24677083
21Nicotine addiction_Homo sapiens_hsa050331.22259837
22Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.22246031
23Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.20965625
24Bile secretion_Homo sapiens_hsa049761.19027831
25Allograft rejection_Homo sapiens_hsa053301.17295840
26NF-kappa B signaling pathway_Homo sapiens_hsa040641.16430887
27GABAergic synapse_Homo sapiens_hsa047271.16167334
28Sphingolipid metabolism_Homo sapiens_hsa006001.15868887
29Tryptophan metabolism_Homo sapiens_hsa003801.14398966
30PPAR signaling pathway_Homo sapiens_hsa033201.13091474
31Toll-like receptor signaling pathway_Homo sapiens_hsa046201.12313887
32Mineral absorption_Homo sapiens_hsa049781.11066968
33Peroxisome_Homo sapiens_hsa041461.09960641
34ABC transporters_Homo sapiens_hsa020101.08364557
35Pertussis_Homo sapiens_hsa051331.07565513
36Toxoplasmosis_Homo sapiens_hsa051451.07422978
37Fatty acid degradation_Homo sapiens_hsa000711.07242218
38Pentose and glucuronate interconversions_Homo sapiens_hsa000401.06822881
39Leishmaniasis_Homo sapiens_hsa051401.06696094
40Butanoate metabolism_Homo sapiens_hsa006501.05827800
41Antigen processing and presentation_Homo sapiens_hsa046121.05436617
42Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.04566932
43Bladder cancer_Homo sapiens_hsa052191.04411547
44Phagosome_Homo sapiens_hsa041451.04340160
45Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.04288152
46Legionellosis_Homo sapiens_hsa051341.02134683
47Steroid biosynthesis_Homo sapiens_hsa001000.99414567
48Osteoclast differentiation_Homo sapiens_hsa043800.97744093
49Collecting duct acid secretion_Homo sapiens_hsa049660.95248876
50Tuberculosis_Homo sapiens_hsa051520.95132749
51Rheumatoid arthritis_Homo sapiens_hsa053230.94544613
52Glutamatergic synapse_Homo sapiens_hsa047240.93983013
53Amoebiasis_Homo sapiens_hsa051460.92912915
54Fatty acid metabolism_Homo sapiens_hsa012120.88203328
55Circadian entrainment_Homo sapiens_hsa047130.86387297
56Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.86292792
57Autoimmune thyroid disease_Homo sapiens_hsa053200.85771763
58Intestinal immune network for IgA production_Homo sapiens_hsa046720.85235292
59Morphine addiction_Homo sapiens_hsa050320.84917862
60Insulin secretion_Homo sapiens_hsa049110.84853989
61Graft-versus-host disease_Homo sapiens_hsa053320.84829979
62Type II diabetes mellitus_Homo sapiens_hsa049300.84715936
63Hepatitis C_Homo sapiens_hsa051600.83756687
64Influenza A_Homo sapiens_hsa051640.83472902
65Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.82953969
66Histidine metabolism_Homo sapiens_hsa003400.82578524
67Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.82357236
68Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.81210878
69Cyanoamino acid metabolism_Homo sapiens_hsa004600.80447378
70Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.80238485
71Pentose phosphate pathway_Homo sapiens_hsa000300.80105665
72African trypanosomiasis_Homo sapiens_hsa051430.78730485
73Steroid hormone biosynthesis_Homo sapiens_hsa001400.78402459
74Renin-angiotensin system_Homo sapiens_hsa046140.78230046
752-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.77646730
76Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.77505524
77RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.76853350
78Salivary secretion_Homo sapiens_hsa049700.75162822
79Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.74967157
80NOD-like receptor signaling pathway_Homo sapiens_hsa046210.73515967
81Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.71879243
82beta-Alanine metabolism_Homo sapiens_hsa004100.71484977
83Shigellosis_Homo sapiens_hsa051310.69881200
84Viral myocarditis_Homo sapiens_hsa054160.69327462
85Renin secretion_Homo sapiens_hsa049240.67869676
86Starch and sucrose metabolism_Homo sapiens_hsa005000.67557262
87Drug metabolism - other enzymes_Homo sapiens_hsa009830.66269546
88Aldosterone synthesis and secretion_Homo sapiens_hsa049250.65788282
89Glutathione metabolism_Homo sapiens_hsa004800.64819208
90Malaria_Homo sapiens_hsa051440.63947973
91Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.62961615
92Cholinergic synapse_Homo sapiens_hsa047250.62510099
93Dopaminergic synapse_Homo sapiens_hsa047280.62462889
94Carbohydrate digestion and absorption_Homo sapiens_hsa049730.61956752
95Chemical carcinogenesis_Homo sapiens_hsa052040.61511889
96Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.60620476
97Apoptosis_Homo sapiens_hsa042100.60124070
98Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.60119994
99Hematopoietic cell lineage_Homo sapiens_hsa046400.58452844
100Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.57902184
101AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.57266041
102Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.56935258
103Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.55865978
104Vitamin B6 metabolism_Homo sapiens_hsa007500.55833833
105Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.54364693
106Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.54258979
107Chemokine signaling pathway_Homo sapiens_hsa040620.54157477
108Amphetamine addiction_Homo sapiens_hsa050310.53298543
109Caffeine metabolism_Homo sapiens_hsa002320.53092917
110Carbon metabolism_Homo sapiens_hsa012000.52537099
111Type I diabetes mellitus_Homo sapiens_hsa049400.51764129
112Maturity onset diabetes of the young_Homo sapiens_hsa049500.51707805
113B cell receptor signaling pathway_Homo sapiens_hsa046620.51613083
114Sulfur relay system_Homo sapiens_hsa041220.50928871
115Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.50747620
116GnRH signaling pathway_Homo sapiens_hsa049120.50728415
117Long-term potentiation_Homo sapiens_hsa047200.50677026
118Notch signaling pathway_Homo sapiens_hsa043300.50356652
119Cocaine addiction_Homo sapiens_hsa050300.50316687
120Leukocyte transendothelial migration_Homo sapiens_hsa046700.50104253
121Propanoate metabolism_Homo sapiens_hsa006400.50002950
122Phenylalanine metabolism_Homo sapiens_hsa003600.49985527
123Gastric acid secretion_Homo sapiens_hsa049710.48704531
124Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.48156339
125Long-term depression_Homo sapiens_hsa047300.47519473
126Fatty acid biosynthesis_Homo sapiens_hsa000610.47271020
127Serotonergic synapse_Homo sapiens_hsa047260.46983279
128Retinol metabolism_Homo sapiens_hsa008300.45977205
129Biosynthesis of amino acids_Homo sapiens_hsa012300.45781726
130Acute myeloid leukemia_Homo sapiens_hsa052210.45473420
131Dorso-ventral axis formation_Homo sapiens_hsa043200.45196032
132Vibrio cholerae infection_Homo sapiens_hsa051100.45085145
133cAMP signaling pathway_Homo sapiens_hsa040240.44200811
134Vitamin digestion and absorption_Homo sapiens_hsa049770.44168172
135Endocytosis_Homo sapiens_hsa041440.43974772
136Salmonella infection_Homo sapiens_hsa051320.43864574
137Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.43682151
138Adipocytokine signaling pathway_Homo sapiens_hsa049200.43518276
139Calcium signaling pathway_Homo sapiens_hsa040200.43451312
140Taste transduction_Homo sapiens_hsa047420.42809054
141Sulfur metabolism_Homo sapiens_hsa009200.42600193
142Hepatitis B_Homo sapiens_hsa051610.42272353
143VEGF signaling pathway_Homo sapiens_hsa043700.41579930
144Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.41562231
145TNF signaling pathway_Homo sapiens_hsa046680.41061198
146Tyrosine metabolism_Homo sapiens_hsa003500.40526809
147Glycerolipid metabolism_Homo sapiens_hsa005610.40248103
148Sphingolipid signaling pathway_Homo sapiens_hsa040710.39531254
149Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.38881273
150Ether lipid metabolism_Homo sapiens_hsa005650.38613332
151Glycerophospholipid metabolism_Homo sapiens_hsa005640.37744061
152Herpes simplex infection_Homo sapiens_hsa051680.36338387
153Fatty acid elongation_Homo sapiens_hsa000620.32926562
154Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.32606350
155Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.32155053

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