ACP6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the histidine acid phosphatase protein family. The encoded protein hydrolyzes lysophosphatidic acid, which is involved in G protein-coupled receptor signaling, lipid raft modulation, and in balancing lipid composition within the cell. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit biogenesis (GO:0042274)4.59417245
2ribosomal small subunit assembly (GO:0000028)4.55550965
3maturation of SSU-rRNA (GO:0030490)4.27408157
4response to pheromone (GO:0019236)4.16198652
5telomere maintenance via semi-conservative replication (GO:0032201)4.12100680
6viral transcription (GO:0019083)4.11870279
7DNA replication initiation (GO:0006270)4.10849034
8DNA deamination (GO:0045006)4.08899949
9DNA strand elongation involved in DNA replication (GO:0006271)4.08322415
10translational termination (GO:0006415)3.99533530
11proteasome assembly (GO:0043248)3.94023298
12ribosomal large subunit biogenesis (GO:0042273)3.93625719
13DNA strand elongation (GO:0022616)3.92006102
14L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.77221172
15branched-chain amino acid catabolic process (GO:0009083)3.74634081
16respiratory chain complex IV assembly (GO:0008535)3.72668545
17rRNA modification (GO:0000154)3.69631167
18nucleobase biosynthetic process (GO:0046112)3.68591344
19preassembly of GPI anchor in ER membrane (GO:0016254)3.66941691
20cytochrome complex assembly (GO:0017004)3.66530111
21protein complex biogenesis (GO:0070271)3.64084577
22ribonucleoprotein complex biogenesis (GO:0022613)3.62151408
23peptidyl-histidine modification (GO:0018202)3.58734679
24mannosylation (GO:0097502)3.55954131
25purine nucleobase biosynthetic process (GO:0009113)3.52363794
26telomere maintenance via telomere lengthening (GO:0010833)3.50188121
27mitochondrial respiratory chain complex assembly (GO:0033108)3.49871598
28telomere maintenance via recombination (GO:0000722)3.49317126
29detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.47853296
30cellular ketone body metabolic process (GO:0046950)3.46815771
31SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.45772595
32translational elongation (GO:0006414)3.44912778
33regulation of mitochondrial translation (GO:0070129)3.43955392
34cotranslational protein targeting to membrane (GO:0006613)3.43202260
35DNA replication checkpoint (GO:0000076)3.43125950
36xenobiotic catabolic process (GO:0042178)3.38991437
37amino acid salvage (GO:0043102)3.38931002
38L-methionine salvage (GO:0071267)3.38931002
39L-methionine biosynthetic process (GO:0071265)3.38931002
40protein targeting to ER (GO:0045047)3.38300556
41regulation of nuclear cell cycle DNA replication (GO:0033262)3.38094305
42ribosome assembly (GO:0042255)3.33675040
43regulation of helicase activity (GO:0051095)3.31245558
44indole-containing compound catabolic process (GO:0042436)3.30721521
45indolalkylamine catabolic process (GO:0046218)3.30721521
46tryptophan catabolic process (GO:0006569)3.30721521
47folic acid-containing compound biosynthetic process (GO:0009396)3.30561905
48GPI anchor metabolic process (GO:0006505)3.29035785
49water-soluble vitamin biosynthetic process (GO:0042364)3.26955411
50chromatin remodeling at centromere (GO:0031055)3.24461158
51regulation of glucokinase activity (GO:0033131)3.23854279
52regulation of hexokinase activity (GO:1903299)3.23854279
53protein localization to endoplasmic reticulum (GO:0070972)3.22554394
54GPI anchor biosynthetic process (GO:0006506)3.21919053
55mitotic recombination (GO:0006312)3.21027831
56rRNA methylation (GO:0031167)3.20544460
57rRNA processing (GO:0006364)3.20098934
58translational initiation (GO:0006413)3.19965067
59serine family amino acid biosynthetic process (GO:0009070)3.18303507
60establishment of protein localization to endoplasmic reticulum (GO:0072599)3.18150208
61indolalkylamine metabolic process (GO:0006586)3.17815926
62CENP-A containing nucleosome assembly (GO:0034080)3.17508421
63transcription-coupled nucleotide-excision repair (GO:0006283)3.17361161
64ribosome biogenesis (GO:0042254)3.16685685
65pteridine-containing compound biosynthetic process (GO:0042559)3.16011685
66DNA unwinding involved in DNA replication (GO:0006268)3.15121396
67glycine metabolic process (GO:0006544)3.15027087
68protein K11-linked deubiquitination (GO:0035871)3.13815575
69protein K6-linked ubiquitination (GO:0085020)3.12603891
70mitotic metaphase plate congression (GO:0007080)3.12038338
71pseudouridine synthesis (GO:0001522)3.10246542
72mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.10239959
73mitochondrial respiratory chain complex I assembly (GO:0032981)3.10239959
74NADH dehydrogenase complex assembly (GO:0010257)3.10239959
75cellular protein complex disassembly (GO:0043624)3.10048586
76rRNA metabolic process (GO:0016072)3.07149767
77nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.06397724
78viral life cycle (GO:0019058)3.05794139
79somatic diversification of immune receptors via somatic mutation (GO:0002566)3.04992340
80somatic hypermutation of immunoglobulin genes (GO:0016446)3.04992340
81cellular component biogenesis (GO:0044085)3.04493638
82transcription from RNA polymerase I promoter (GO:0006360)3.04289106
83tryptophan metabolic process (GO:0006568)3.03681574
84nucleotide-excision repair, DNA gap filling (GO:0006297)3.03465233
85ketone body metabolic process (GO:1902224)3.02884283
86response to nitrosative stress (GO:0051409)3.02647168
87S-adenosylmethionine metabolic process (GO:0046500)3.02642589
88ubiquinone biosynthetic process (GO:0006744)3.01665643
89establishment of integrated proviral latency (GO:0075713)3.01607390
90termination of RNA polymerase III transcription (GO:0006386)3.01400480
91transcription elongation from RNA polymerase III promoter (GO:0006385)3.01400480
92translation (GO:0006412)3.00887370
93L-serine metabolic process (GO:0006563)3.00773717
94formation of translation preinitiation complex (GO:0001731)2.99187347
95regulation of cilium movement (GO:0003352)2.96353762
96regulation of double-strand break repair via homologous recombination (GO:0010569)2.96212217
97rRNA catabolic process (GO:0016075)2.95411961
98C-terminal protein lipidation (GO:0006501)2.94302529
99termination of RNA polymerase I transcription (GO:0006363)2.93944520
100oxidative demethylation (GO:0070989)2.93792543
101aromatic amino acid family catabolic process (GO:0009074)2.93733446
102IMP biosynthetic process (GO:0006188)2.93531192
103adenosine metabolic process (GO:0046085)2.92869070
104detection of light stimulus involved in sensory perception (GO:0050962)2.91460463
105detection of light stimulus involved in visual perception (GO:0050908)2.91460463
106adaptation of signaling pathway (GO:0023058)2.90773789
107benzene-containing compound metabolic process (GO:0042537)2.90743959
108C-terminal protein amino acid modification (GO:0018410)2.90696227
109kynurenine metabolic process (GO:0070189)2.89879507
110mitochondrial DNA replication (GO:0006264)2.89300026
111transcription elongation from RNA polymerase I promoter (GO:0006362)2.88712770
1127-methylguanosine mRNA capping (GO:0006370)2.88590159
113exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.88030338
114kinetochore assembly (GO:0051382)2.87838914
115spliceosomal snRNP assembly (GO:0000387)2.87811943
116branched-chain amino acid metabolic process (GO:0009081)2.87533108
117metaphase plate congression (GO:0051310)2.87051798
118RNA capping (GO:0036260)2.85374294
1197-methylguanosine RNA capping (GO:0009452)2.85374294
120kinetochore organization (GO:0051383)2.85155277
121replication fork processing (GO:0031297)2.84369144
122tetrahydrofolate metabolic process (GO:0046653)2.82999284
123nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.81080379
124regulation of hippo signaling (GO:0035330)2.80045673
125mitochondrial RNA metabolic process (GO:0000959)2.79170426
126epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.76777142
127regulation of gene silencing by miRNA (GO:0060964)2.76576418
128regulation of gene silencing by RNA (GO:0060966)2.76576418
129regulation of posttranscriptional gene silencing (GO:0060147)2.76576418
130tRNA methylation (GO:0030488)2.76431884
131folic acid metabolic process (GO:0046655)2.75934279
132DNA damage response, detection of DNA damage (GO:0042769)2.75362611
133protein-cofactor linkage (GO:0018065)2.75150522
134photoreceptor cell maintenance (GO:0045494)2.73710979
135RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.73638366
136sulfation (GO:0051923)2.72368668
137platelet dense granule organization (GO:0060155)2.71480680
138transcription initiation from RNA polymerase I promoter (GO:0006361)2.70454994
139axoneme assembly (GO:0035082)2.69753866
140fucose catabolic process (GO:0019317)2.69681183
141L-fucose metabolic process (GO:0042354)2.69681183
142L-fucose catabolic process (GO:0042355)2.69681183
143neural tube formation (GO:0001841)2.68780110
144DNA replication-dependent nucleosome assembly (GO:0006335)2.68181038
145DNA replication-dependent nucleosome organization (GO:0034723)2.68181038
146seminiferous tubule development (GO:0072520)2.66395544
147proline metabolic process (GO:0006560)2.66318693
148protein complex disassembly (GO:0043241)2.66254608
149aromatic amino acid family metabolic process (GO:0009072)2.65498194
150flavonoid metabolic process (GO:0009812)2.65268687
151pteridine-containing compound metabolic process (GO:0042558)2.64114008
152pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.63341439
153DNA-dependent DNA replication (GO:0006261)2.62341852
154serine family amino acid metabolic process (GO:0009069)2.62209509
155meiotic chromosome segregation (GO:0045132)2.61409387
156RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.61370250
157tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.61370250
158dopamine transport (GO:0015872)2.60933354
159DNA demethylation (GO:0080111)2.60821853
160epithelial cilium movement (GO:0003351)2.60397626
161maturation of 5.8S rRNA (GO:0000460)2.60210765
162metallo-sulfur cluster assembly (GO:0031163)2.59479964
163iron-sulfur cluster assembly (GO:0016226)2.59479964
164behavioral response to nicotine (GO:0035095)2.59420503
165DNA replication-independent nucleosome assembly (GO:0006336)2.59277498
166DNA replication-independent nucleosome organization (GO:0034724)2.59277498
167telomere organization (GO:0032200)2.59232039
168folic acid-containing compound metabolic process (GO:0006760)2.59214909
169methionine biosynthetic process (GO:0009086)2.58863572
170anterograde synaptic vesicle transport (GO:0048490)2.58576276
171cilium morphogenesis (GO:0060271)2.58318821
172DNA dealkylation (GO:0035510)2.58220353
173telomere maintenance (GO:0000723)2.58009017
174ubiquinone metabolic process (GO:0006743)2.57475185
175mismatch repair (GO:0006298)2.57169936
176IMP metabolic process (GO:0046040)2.56925475
177quinone biosynthetic process (GO:1901663)2.56311278
178lactate metabolic process (GO:0006089)2.54968646
179base-excision repair, AP site formation (GO:0006285)2.52574102
180reflex (GO:0060004)2.52180979
181L-phenylalanine catabolic process (GO:0006559)2.52121863
182erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.52121863
183cilium or flagellum-dependent cell motility (GO:0001539)2.50323933
184aggressive behavior (GO:0002118)2.49990959
185thyroid hormone metabolic process (GO:0042403)2.48539064
186recombinational repair (GO:0000725)2.48044079
187aspartate family amino acid catabolic process (GO:0009068)2.47209959
188double-strand break repair via homologous recombination (GO:0000724)2.46922018
189cilium organization (GO:0044782)2.45984042
190GMP metabolic process (GO:0046037)2.41287694
191regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.40320190
192tRNA processing (GO:0008033)2.39464776
193cilium assembly (GO:0042384)2.39462132
194piRNA metabolic process (GO:0034587)2.38410024
195artery smooth muscle contraction (GO:0014824)2.35784839

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.16496954
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.26507792
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.73856776
4ZNF274_21170338_ChIP-Seq_K562_Hela3.54563359
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.13856235
6VDR_22108803_ChIP-Seq_LS180_Human3.07393178
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.01662216
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.99068314
9MYC_19079543_ChIP-ChIP_MESCs_Mouse2.95940851
10GBX2_23144817_ChIP-Seq_PC3_Human2.95539480
11E2F4_17652178_ChIP-ChIP_JURKAT_Human2.92850876
12MYC_18358816_ChIP-ChIP_MESCs_Mouse2.82433809
13* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.81404293
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.80126615
15EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.72825317
16* NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.70495185
17* ETS1_20019798_ChIP-Seq_JURKAT_Human2.70013401
18FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.69399757
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.64547240
20FOXM1_23109430_ChIP-Seq_U2OS_Human2.50073083
21* HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.48103551
22CREB1_15753290_ChIP-ChIP_HEK293T_Human2.46858169
23IGF1R_20145208_ChIP-Seq_DFB_Human2.43862786
24GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.42727002
25NANOG_18555785_ChIP-Seq_MESCs_Mouse2.37947565
26KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.24510373
27KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.24510373
28KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.24510373
29* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.21252079
30* FUS_26573619_Chip-Seq_HEK293_Human2.18996545
31HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.15487108
32NELFA_20434984_ChIP-Seq_ESCs_Mouse2.12108900
33TAF15_26573619_Chip-Seq_HEK293_Human2.11548629
34* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.10628275
35ELF1_17652178_ChIP-ChIP_JURKAT_Human2.10215613
36SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.10134292
37EWS_26573619_Chip-Seq_HEK293_Human2.09885660
38POU3F2_20337985_ChIP-ChIP_501MEL_Human2.08833616
39FLI1_27457419_Chip-Seq_LIVER_Mouse2.08264647
40XRN2_22483619_ChIP-Seq_HELA_Human2.07904361
41HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.06306016
42VDR_23849224_ChIP-Seq_CD4+_Human2.04770929
43FOXP3_21729870_ChIP-Seq_TREG_Human1.94825711
44* SRF_21415370_ChIP-Seq_HL-1_Mouse1.94237552
45ZFP57_27257070_Chip-Seq_ESCs_Mouse1.92319717
46YY1_21170310_ChIP-Seq_MESCs_Mouse1.89777435
47EGR1_23403033_ChIP-Seq_LIVER_Mouse1.88239819
48CTBP2_25329375_ChIP-Seq_LNCAP_Human1.87199827
49* SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.85636479
50* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.85551319
51* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.85351269
52* ER_23166858_ChIP-Seq_MCF-7_Human1.83764230
53CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.79544354
54PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.77936815
55EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.77528629
56POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.76613947
57DCP1A_22483619_ChIP-Seq_HELA_Human1.75887531
58PCGF2_27294783_Chip-Seq_ESCs_Mouse1.75759278
59STAT3_1855785_ChIP-Seq_MESCs_Mouse1.74095823
60* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.71998967
61CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.70993278
62ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.70313862
63THAP11_20581084_ChIP-Seq_MESCs_Mouse1.69702985
64MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.69382599
65* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.68450848
66CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.63100320
67AR_20517297_ChIP-Seq_VCAP_Human1.62644907
68FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.61570659
69FOXA1_27270436_Chip-Seq_PROSTATE_Human1.61200135
70FOXA1_25329375_ChIP-Seq_VCAP_Human1.61200135
71TTF2_22483619_ChIP-Seq_HELA_Human1.60914842
72P300_19829295_ChIP-Seq_ESCs_Human1.60784994
73MYCN_18555785_ChIP-Seq_MESCs_Mouse1.54760026
74PIAS1_25552417_ChIP-Seq_VCAP_Human1.53355677
75NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.52270719
76TP53_22573176_ChIP-Seq_HFKS_Human1.51984874
77* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.51443075
78* TCF3_18692474_ChIP-Seq_MEFs_Mouse1.51042687
79IRF1_19129219_ChIP-ChIP_H3396_Human1.48880400
80ELK1_19687146_ChIP-ChIP_HELA_Human1.47486717
81GABP_19822575_ChIP-Seq_HepG2_Human1.46726197
82* SOX2_18555785_ChIP-Seq_MESCs_Mouse1.45696005
83GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.45558468
84PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.45240518
85CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.45208892
86MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.43816717
87AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.40646661
88IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.40571559
89CBP_20019798_ChIP-Seq_JUKART_Human1.40571559
90AR_21909140_ChIP-Seq_LNCAP_Human1.39314745
91SALL1_21062744_ChIP-ChIP_HESCs_Human1.38651182
92FOXA1_21572438_ChIP-Seq_LNCaP_Human1.35119381
93* NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.34390531
94FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.33111221
95* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.31634776
96YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.30072546
97ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.28679907
98STAT3_23295773_ChIP-Seq_U87_Human1.28296031
99E2F1_21310950_ChIP-Seq_MCF-7_Human1.27922684
100TCF4_22108803_ChIP-Seq_LS180_Human1.27516379
101TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.27397838
102* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.23639844
103AR_25329375_ChIP-Seq_VCAP_Human1.22360426
104EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.21240994
105FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.21167866
106* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.21118044
107UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.20908404
108KLF5_20875108_ChIP-Seq_MESCs_Mouse1.20486469
109ERG_20887958_ChIP-Seq_HPC-7_Mouse1.19764594
110NR3C1_21868756_ChIP-Seq_MCF10A_Human1.19059096
111CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.18303923
112PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18203991
113BCAT_22108803_ChIP-Seq_LS180_Human1.17673750
114* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.17516949
115GATA3_21878914_ChIP-Seq_MCF-7_Human1.16901441
116NCOR_22424771_ChIP-Seq_293T_Human1.16796227
117TCF4_23295773_ChIP-Seq_U87_Human1.16743944
118NANOG_19829295_ChIP-Seq_ESCs_Human1.16577675
119SOX2_19829295_ChIP-Seq_ESCs_Human1.16577675
120* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.16010130
121* NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.15183788
122MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.13283315
123PCGF2_27294783_Chip-Seq_NPCs_Mouse1.12592099
124* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.12184792
125NFE2_27457419_Chip-Seq_LIVER_Mouse1.11055831
126HOXB7_26014856_ChIP-Seq_BT474_Human1.10971396
127KDM5A_27292631_Chip-Seq_BREAST_Human1.10731404
128SUZ12_27294783_Chip-Seq_NPCs_Mouse1.09984427
129* SMAD4_21799915_ChIP-Seq_A2780_Human1.08785598
130CDX2_22108803_ChIP-Seq_LS180_Human1.07935713
131KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.07746757
132EZH2_27294783_Chip-Seq_NPCs_Mouse1.07389446
133ETV2_25802403_ChIP-Seq_MESCs_Mouse1.07204923
134ERG_20517297_ChIP-Seq_VCAP_Human1.05677475
135PADI4_21655091_ChIP-ChIP_MCF-7_Human1.04944684
136MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.04834981
137GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.04274357
138* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.03035888
139* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.02925262
140SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.02634896
141CIITA_25753668_ChIP-Seq_RAJI_Human1.01658092
142* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.01190687
143MYC_18940864_ChIP-ChIP_HL60_Human1.00813248
144CRX_20693478_ChIP-Seq_RETINA_Mouse0.99666829
145NOTCH1_21737748_ChIP-Seq_TLL_Human0.98684129
146* NANOG_18692474_ChIP-Seq_MEFs_Mouse0.96764561
147KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.96618137
148AUTS2_25519132_ChIP-Seq_293T-REX_Human0.96323166
149SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.94829644
150ERA_21632823_ChIP-Seq_H3396_Human0.94724362
151BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.94201154
152SMAD3_21741376_ChIP-Seq_EPCs_Human0.92505350
153* SOX2_18692474_ChIP-Seq_MESCs_Mouse0.92431777
154* RUNX2_22187159_ChIP-Seq_PCA_Human0.92055479
155RBPJ_22232070_ChIP-Seq_NCS_Mouse0.91720803
156* MYC_19829295_ChIP-Seq_ESCs_Human0.91541744
157* SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.91208272
158* KAP1_22055183_ChIP-Seq_ESCs_Mouse0.90153387
159AR_21572438_ChIP-Seq_LNCaP_Human0.89768875
160CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.89653878
161PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.88894534
162SMAD4_21741376_ChIP-Seq_EPCs_Human0.88612617
163* CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.88380598
164KAP1_27257070_Chip-Seq_ESCs_Mouse0.87116168
165SOX17_20123909_ChIP-Seq_XEN_Mouse0.86996371
166* POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.85576555
167PPARA_22158963_ChIP-Seq_LIVER_Mouse0.85511586
168RXR_22158963_ChIP-Seq_LIVER_Mouse0.84764423
169SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.82928696
170* POU5F1_16518401_ChIP-PET_MESCs_Mouse0.78922220
171E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.78760049

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis4.79705587
2MP0008057_abnormal_DNA_replication4.38084987
3MP0003693_abnormal_embryo_hatching3.87853731
4MP0010094_abnormal_chromosome_stability3.55656817
5MP0003111_abnormal_nucleus_morphology3.35808464
6MP0004957_abnormal_blastocyst_morpholog3.35282892
7MP0008058_abnormal_DNA_repair3.16023777
8MP0005360_urolithiasis2.96603759
9MP0003077_abnormal_cell_cycle2.90323458
10MP0002102_abnormal_ear_morphology2.73671840
11MP0003136_yellow_coat_color2.70973254
12MP0002139_abnormal_hepatobiliary_system2.69464686
13MP0003718_maternal_effect2.64393812
14MP0005085_abnormal_gallbladder_physiolo2.47146046
15MP0002138_abnormal_hepatobiliary_system2.42344899
16MP0003186_abnormal_redox_activity2.33708465
17MP0004043_abnormal_pH_regulation2.18856033
18MP0005551_abnormal_eye_electrophysiolog2.15202317
19MP0008932_abnormal_embryonic_tissue2.12687032
20MP0009379_abnormal_foot_pigmentation2.09447911
21MP0003786_premature_aging2.07757590
22MP0008007_abnormal_cellular_replicative2.05548092
23MP0002837_dystrophic_cardiac_calcinosis1.99965051
24MP0003878_abnormal_ear_physiology1.99199676
25MP0005377_hearing/vestibular/ear_phenot1.99199676
26MP0003941_abnormal_skin_development1.98184938
27MP0005365_abnormal_bile_salt1.97047479
28MP0002876_abnormal_thyroid_physiology1.88643459
29MP0002938_white_spotting1.83621715
30MP0004133_heterotaxia1.80138418
31MP0004147_increased_porphyrin_level1.79159171
32MP0001984_abnormal_olfaction1.77724683
33MP0006292_abnormal_olfactory_placode1.73154115
34MP0006072_abnormal_retinal_apoptosis1.66634457
35MP0000569_abnormal_digit_pigmentation1.63965866
36MP0009697_abnormal_copulation1.59728305
37MP0005451_abnormal_body_composition1.58585859
38MP0005075_abnormal_melanosome_morpholog1.56946384
39MP0008875_abnormal_xenobiotic_pharmacok1.53389402
40MP0008877_abnormal_DNA_methylation1.53318288
41MP0001764_abnormal_homeostasis1.51333786
42MP0003950_abnormal_plasma_membrane1.51112527
43MP0005332_abnormal_amino_acid1.50896084
44MP0006036_abnormal_mitochondrial_physio1.48239178
45MP0005084_abnormal_gallbladder_morpholo1.47115971
46MP0005266_abnormal_metabolism1.44917584
47MP0002928_abnormal_bile_duct1.42609476
48MP0000383_abnormal_hair_follicle1.40173145
49MP0010386_abnormal_urinary_bladder1.38391862
50MP0002638_abnormal_pupillary_reflex1.36215196
51MP0005253_abnormal_eye_physiology1.32476828
52MP0009840_abnormal_foam_cell1.32304736
53MP0002234_abnormal_pharynx_morphology1.31978930
54MP0005645_abnormal_hypothalamus_physiol1.29026036
55MP0005646_abnormal_pituitary_gland1.28655442
56MP0001485_abnormal_pinna_reflex1.26960554
57MP0001986_abnormal_taste_sensitivity1.26585300
58MP0003787_abnormal_imprinting1.25933750
59MP0002736_abnormal_nociception_after1.25844934
60MP0005367_renal/urinary_system_phenotyp1.25035699
61MP0000516_abnormal_urinary_system1.25035699
62MP0002132_abnormal_respiratory_system1.24595362
63MP0004019_abnormal_vitamin_homeostasis1.24220685
64MP0001968_abnormal_touch/_nociception1.23284317
65MP0000350_abnormal_cell_proliferation1.22351558
66MP0004381_abnormal_hair_follicle1.20855324
67MP0000490_abnormal_crypts_of1.20562883
68MP0002396_abnormal_hematopoietic_system1.20101301
69MP0006035_abnormal_mitochondrial_morpho1.19465228
70MP0005501_abnormal_skin_physiology1.19313147
71MP0005410_abnormal_fertilization1.18614422
72MP0000372_irregular_coat_pigmentation1.18218837
73MP0002210_abnormal_sex_determination1.17918670
74MP0001730_embryonic_growth_arrest1.17064232
75MP0002796_impaired_skin_barrier1.15532199
76MP0005408_hypopigmentation1.14959768
77MP0002693_abnormal_pancreas_physiology1.12081587
78MP0002160_abnormal_reproductive_system1.11002324
79MP0009046_muscle_twitch1.07503003
80MP0005636_abnormal_mineral_homeostasis1.05704954
81MP0003121_genomic_imprinting1.05325993
82MP0000427_abnormal_hair_cycle1.05221792
83MP0001501_abnormal_sleep_pattern1.05156646
84MP0002277_abnormal_respiratory_mucosa1.04703335
85MP0000566_synostosis1.03718442
86MP0001853_heart_inflammation1.03502011
87MP0000647_abnormal_sebaceous_gland1.03296677
88MP0001145_abnormal_male_reproductive1.01522238
89MP0004215_abnormal_myocardial_fiber1.00166614
90MP0000313_abnormal_cell_death0.97858205
91MP0005395_other_phenotype0.96771136
92MP0002019_abnormal_tumor_incidence0.95707562
93MP0005220_abnormal_exocrine_pancreas0.94992258
94MP0003195_calcinosis0.91467612
95MP0005376_homeostasis/metabolism_phenot0.90909780
96MP0001929_abnormal_gametogenesis0.90313642
97MP0001666_abnormal_nutrient_absorption0.89954965
98MP0000653_abnormal_sex_gland0.89827129
99MP0003183_abnormal_peptide_metabolism0.89317952
100MP0001905_abnormal_dopamine_level0.89137260
101MP0005647_abnormal_sex_gland0.88849055
102MP0003698_abnormal_male_reproductive0.87870817
103MP0010352_gastrointestinal_tract_polyps0.86666995
104MP0000230_abnormal_systemic_arterial0.86108246
105MP0001756_abnormal_urination0.85758707
106MP0008995_early_reproductive_senescence0.85429537
107MP0003191_abnormal_cellular_cholesterol0.84395992
108MP0006276_abnormal_autonomic_nervous0.83426726
109MP0003252_abnormal_bile_duct0.83180617
110MP0005174_abnormal_tail_pigmentation0.82738089
111MP0009765_abnormal_xenobiotic_induced0.82726210
112MP0001672_abnormal_embryogenesis/_devel0.82265268
113MP0005380_embryogenesis_phenotype0.82265268
114MP0003122_maternal_imprinting0.82154328
115MP0003646_muscle_fatigue0.82149973
116MP0003137_abnormal_impulse_conducting0.81945007
117MP0009643_abnormal_urine_homeostasis0.81538328
118MP0002282_abnormal_trachea_morphology0.80216908
119MP0001661_extended_life_span0.80199526
120MP0002909_abnormal_adrenal_gland0.80195080
121MP0001529_abnormal_vocalization0.79841005
122MP0001486_abnormal_startle_reflex0.79299777
123MP0002168_other_aberrant_phenotype0.79043322
124MP0005319_abnormal_enzyme/_coenzyme0.79039716
125MP0003943_abnormal_hepatobiliary_system0.78617464
126MP0000631_abnormal_neuroendocrine_gland0.78576855
127MP0009763_increased_sensitivity_to0.77723536
128MP0002085_abnormal_embryonic_tissue0.76616254
129MP0010329_abnormal_lipoprotein_level0.76593772
130MP0001324_abnormal_eye_pigmentation0.76569853
131MP0008789_abnormal_olfactory_epithelium0.75714857
132MP0004142_abnormal_muscle_tone0.74998048
133MP0005670_abnormal_white_adipose0.73947399
134MP0001697_abnormal_embryo_size0.73664567
135MP0001119_abnormal_female_reproductive0.73467494
136MP0002080_prenatal_lethality0.73031007
137MP0003763_abnormal_thymus_physiology0.70143462
138MP0003011_delayed_dark_adaptation0.68072303
139MP0010307_abnormal_tumor_latency0.67968622
140MP0000689_abnormal_spleen_morphology0.67143808
141MP0000609_abnormal_liver_physiology0.67006433
142MP0001186_pigmentation_phenotype0.66344604
143MP0008872_abnormal_physiological_respon0.65656447
144MP0005409_darkened_coat_color0.65551625
145MP0005389_reproductive_system_phenotype0.64178274
146MP0001293_anophthalmia0.63141905
147MP0000613_abnormal_salivary_gland0.62467288
148MP0005083_abnormal_biliary_tract0.62043977
149MP0003724_increased_susceptibility_to0.62037124
150MP0003936_abnormal_reproductive_system0.60059262
151MP0008873_increased_physiological_sensi0.59673677
152MP0002722_abnormal_immune_system0.58743990
153MP0003123_paternal_imprinting0.58672109
154MP0002653_abnormal_ependyma_morphology0.58185599
155MP0005171_absent_coat_pigmentation0.57568362
156MP0003984_embryonic_growth_retardation0.56655272
157MP0002075_abnormal_coat/hair_pigmentati0.55516872
158MP0000598_abnormal_liver_morphology0.55287841
159MP0002086_abnormal_extraembryonic_tissu0.54753475

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)4.28874917
2Pancreatic cysts (HP:0001737)4.23433642
3True hermaphroditism (HP:0010459)4.03929880
4Birth length less than 3rd percentile (HP:0003561)4.02433708
5Duplicated collecting system (HP:0000081)3.94280544
6Breast hypoplasia (HP:0003187)3.91629643
7Chromosomal breakage induced by crosslinking agents (HP:0003221)3.73561969
8Pancreatic fibrosis (HP:0100732)3.73352429
9Chromsome breakage (HP:0040012)3.71910565
10Abnormality of cells of the erythroid lineage (HP:0012130)3.53734548
11Abnormality of the renal collecting system (HP:0004742)3.43443350
12Abnormality of midbrain morphology (HP:0002418)3.37656602
13Molar tooth sign on MRI (HP:0002419)3.37656602
14Abnormality of pyrimidine metabolism (HP:0004353)3.31815942
15Oral leukoplakia (HP:0002745)3.26546966
16Abnormal number of erythroid precursors (HP:0012131)3.20474566
17Abnormality of the renal cortex (HP:0011035)3.19926430
18Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.19498196
19Congenital stationary night blindness (HP:0007642)3.19208619
20Macrocytic anemia (HP:0001972)3.15753535
21Attenuation of retinal blood vessels (HP:0007843)3.06940925
22Abolished electroretinogram (ERG) (HP:0000550)3.04223924
23Nephronophthisis (HP:0000090)3.01389984
24Bile duct proliferation (HP:0001408)3.00007880
25Abnormal biliary tract physiology (HP:0012439)3.00007880
263-Methylglutaconic aciduria (HP:0003535)2.93735150
27Aplasia/Hypoplasia of the sacrum (HP:0008517)2.90997167
28Progressive external ophthalmoplegia (HP:0000590)2.90714650
29Intrahepatic cholestasis (HP:0001406)2.88995623
30Medial flaring of the eyebrow (HP:0010747)2.88736785
31Abnormality of monocarboxylic acid metabolism (HP:0010996)2.84826897
32Aplastic anemia (HP:0001915)2.83231259
33Large for gestational age (HP:0001520)2.81654673
34Cystic liver disease (HP:0006706)2.81304607
35Chronic hepatic failure (HP:0100626)2.79641486
36Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.79169598
37Type II lissencephaly (HP:0007260)2.76671005
38Decreased activity of mitochondrial respiratory chain (HP:0008972)2.76035999
39Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.76035999
40Abnormality of the renal medulla (HP:0100957)2.71176093
41Ketoacidosis (HP:0001993)2.67977281
42Renal cortical cysts (HP:0000803)2.63794524
43Hepatic necrosis (HP:0002605)2.60447755
44Abnormality of the preputium (HP:0100587)2.60271043
45Ketosis (HP:0001946)2.58547115
46Decreased electroretinogram (ERG) amplitude (HP:0000654)2.57559714
47Increased serum lactate (HP:0002151)2.56859969
48Hepatocellular necrosis (HP:0001404)2.56416887
49Rough bone trabeculation (HP:0100670)2.50683094
50Abnormality of aromatic amino acid family metabolism (HP:0004338)2.50463839
51Acute encephalopathy (HP:0006846)2.47778517
52Cerebral hypomyelination (HP:0006808)2.47511443
53Abnormal rod and cone electroretinograms (HP:0008323)2.47319987
54Acute necrotizing encephalopathy (HP:0006965)2.45189169
55Mitochondrial inheritance (HP:0001427)2.43037364
56Cerebral edema (HP:0002181)2.42996853
57Abnormality of chromosome stability (HP:0003220)2.42596232
58Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.38911045
59Abnormal protein N-linked glycosylation (HP:0012347)2.38911045
60Abnormal protein glycosylation (HP:0012346)2.38911045
61Abnormal glycosylation (HP:0012345)2.38911045
62Methylmalonic acidemia (HP:0002912)2.38399133
63Absent radius (HP:0003974)2.38044629
64Microvesicular hepatic steatosis (HP:0001414)2.37379054
65Sclerocornea (HP:0000647)2.36949604
66Increased hepatocellular lipid droplets (HP:0006565)2.36729749
67Absent thumb (HP:0009777)2.36562778
68Increased CSF lactate (HP:0002490)2.35329807
69Hyperglycinuria (HP:0003108)2.35023954
70Tubulointerstitial nephritis (HP:0001970)2.34617193
71Supernumerary spleens (HP:0009799)2.33210526
72Asplenia (HP:0001746)2.32707522
73Pancytopenia (HP:0001876)2.31633272
74Hyperventilation (HP:0002883)2.31212576
75Pallor (HP:0000980)2.31092211
76Agnosia (HP:0010524)2.30066317
77Hypobetalipoproteinemia (HP:0003563)2.29866755
78Methylmalonic aciduria (HP:0012120)2.29421716
79Meckel diverticulum (HP:0002245)2.29287074
80Polydipsia (HP:0001959)2.29264944
81Abnormal drinking behavior (HP:0030082)2.29264944
82Gaze-evoked nystagmus (HP:0000640)2.28302597
83Postaxial foot polydactyly (HP:0001830)2.27793203
84Lipid accumulation in hepatocytes (HP:0006561)2.27167552
85Stenosis of the external auditory canal (HP:0000402)2.26035039
86Renal Fanconi syndrome (HP:0001994)2.25953030
87Type I transferrin isoform profile (HP:0003642)2.24240807
88Proximal tubulopathy (HP:0000114)2.22973051
89Abnormality of the ileum (HP:0001549)2.22891749
90Aplasia/hypoplasia of the uterus (HP:0008684)2.22273315
91Absent forearm bone (HP:0003953)2.22158740
92Aplasia involving forearm bones (HP:0009822)2.22158740
93Tubular atrophy (HP:0000092)2.19100764
94Medulloblastoma (HP:0002885)2.18874538
95Rhabdomyosarcoma (HP:0002859)2.18473110
96Long foot (HP:0001833)2.18453404
97Congenital hepatic fibrosis (HP:0002612)2.18239435
98Congenital primary aphakia (HP:0007707)2.17084884
99Abnormal mitochondria in muscle tissue (HP:0008316)2.13905991
100Male pseudohermaphroditism (HP:0000037)2.11987553
101Lethargy (HP:0001254)2.11430319
102Colon cancer (HP:0003003)2.09873735
103Ependymoma (HP:0002888)2.09131982
104Abnormality of methionine metabolism (HP:0010901)2.09068081
105Premature graying of hair (HP:0002216)2.08466063
106Progressive macrocephaly (HP:0004481)2.07596950
107Aplasia/Hypoplasia of the uvula (HP:0010293)2.07397122
108Abnormal trabecular bone morphology (HP:0100671)2.07148993
109Nephrogenic diabetes insipidus (HP:0009806)2.06323433
110Furrowed tongue (HP:0000221)2.06292776
111Bone marrow hypocellularity (HP:0005528)2.05235674
112Increased intramyocellular lipid droplets (HP:0012240)2.03667955
113Exercise intolerance (HP:0003546)2.02926457
114Hyperglycinemia (HP:0002154)2.02040849
115Aplasia/Hypoplasia of the tongue (HP:0010295)2.01793209
116Aplasia/Hypoplasia of the spleen (HP:0010451)2.01519050
117Opisthotonus (HP:0002179)2.01169041
118Abnormality of glycine metabolism (HP:0010895)2.00200572
119Abnormality of serine family amino acid metabolism (HP:0010894)2.00200572
120Lactic acidosis (HP:0003128)2.00024868
121Bony spicule pigmentary retinopathy (HP:0007737)2.00011974
122Impulsivity (HP:0100710)1.99575724
123Hypoplasia of the uterus (HP:0000013)1.99029816
124Gait imbalance (HP:0002141)1.98907609
125Retinal dysplasia (HP:0007973)1.98814475
126Progressive muscle weakness (HP:0003323)1.97374140
127Hyperammonemia (HP:0001987)1.96961664
128Abnormality of aspartate family amino acid metabolism (HP:0010899)1.96690600
129Generalized aminoaciduria (HP:0002909)1.96342091
130Cerebellar dysplasia (HP:0007033)1.94491571
131Absent rod-and cone-mediated responses on ERG (HP:0007688)1.93498771
132Clubbing of toes (HP:0100760)1.92504182
133Occipital encephalocele (HP:0002085)1.92376806
134Abnormality of B cell number (HP:0010975)1.91522390
135Absent/shortened dynein arms (HP:0200106)1.90922643
136Dynein arm defect of respiratory motile cilia (HP:0012255)1.90922643
137Exertional dyspnea (HP:0002875)1.90495116
138Megaloblastic anemia (HP:0001889)1.89722555
139Ureteral duplication (HP:0000073)1.89379254
140Decreased central vision (HP:0007663)1.89188337
141Genital tract atresia (HP:0001827)1.87192979
142Acute lymphatic leukemia (HP:0006721)1.86940834
143CNS demyelination (HP:0007305)1.86874520
144Enlarged kidneys (HP:0000105)1.85876961
145Premature ovarian failure (HP:0008209)1.85529166
146Vaginal atresia (HP:0000148)1.84459839
147Hypothermia (HP:0002045)1.83832796
148Increased muscle lipid content (HP:0009058)1.83817083
149Constricted visual fields (HP:0001133)1.83619514
150Patellar aplasia (HP:0006443)1.82980738
151Dicarboxylic aciduria (HP:0003215)1.82357529
152Abnormality of dicarboxylic acid metabolism (HP:0010995)1.82357529
153Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.82291771
154Abnormality of alanine metabolism (HP:0010916)1.82291771
155Hyperalaninemia (HP:0003348)1.82291771
156Reduced antithrombin III activity (HP:0001976)1.81940275
157Abnormality of the labia minora (HP:0012880)1.81398659
158External ophthalmoplegia (HP:0000544)1.81283707
159Small intestinal stenosis (HP:0012848)1.80847422
160Duodenal stenosis (HP:0100867)1.80847422
161Leukodystrophy (HP:0002415)1.80283628
162Myelodysplasia (HP:0002863)1.80132014
163Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.80092674
164Abnormality of the axillary hair (HP:0100134)1.78194588
165Abnormality of secondary sexual hair (HP:0009888)1.78194588
166Triphalangeal thumb (HP:0001199)1.78094177
167Abnormality of serum amino acid levels (HP:0003112)1.77775581
168Abnormal respiratory motile cilium morphology (HP:0005938)1.76983738
169Abnormal respiratory epithelium morphology (HP:0012253)1.76983738
170Sex reversal (HP:0012245)1.76181642
171Abnormal sex determination (HP:0012244)1.76181642
172CNS hypomyelination (HP:0003429)1.76039272
173Inability to walk (HP:0002540)1.75630314
174Stage 5 chronic kidney disease (HP:0003774)1.75423628
175Anencephaly (HP:0002323)1.73881844
176Polyuria (HP:0000103)1.73855370
177Abnormality of macular pigmentation (HP:0008002)1.72915337
178Glycosuria (HP:0003076)1.72464585
179Abnormality of urine glucose concentration (HP:0011016)1.72464585

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.66044847
2BUB14.01485974
3WEE13.68056671
4BMPR1B3.43876636
5STK163.09437555
6VRK22.88105269
7IRAK32.87292938
8MAP4K22.71064295
9WNK32.67876618
10TTK2.63547935
11BCKDK2.60136389
12EIF2AK12.57965227
13EPHA22.48975075
14ZAK2.47853821
15NUAK12.35790258
16VRK12.33814675
17NME22.33768862
18CDC72.32796763
19WNK42.32583629
20PBK2.12411225
21RPS6KB22.04361665
22PLK42.03345326
23EIF2AK32.03103816
24SRPK11.93753695
25TSSK61.85074266
26STK391.82331402
27CDK71.80768700
28TLK11.77637736
29AKT31.73492736
30PLK11.73401889
31INSRR1.60772826
32TAOK31.56384605
33CDK81.55175086
34ACVR1B1.51985975
35MST1R1.47733726
36ATR1.46597727
37IRAK41.41329505
38AURKB1.39507250
39PNCK1.35315443
40PINK11.34691810
41BRSK21.30654133
42FGFR21.30503751
43TESK21.28799460
44PHKG21.28101438
45PHKG11.28101438
46STK41.27821942
47AURKA1.27050203
48NEK21.25276376
49CSNK1G11.21874497
50DYRK31.20548502
51FLT31.19299320
52MST41.17004575
53CHEK21.16463530
54PASK1.04268861
55PLK31.04199110
56BRD41.01660812
57EIF2AK21.01658837
58ADRBK21.01496004
59CDK121.00424591
60MKNK10.99925972
61MAPKAPK30.99713750
62IRAK10.99674712
63LMTK20.97855241
64NLK0.95351285
65CSNK1G30.92797528
66NME10.90630217
67PIM20.90581241
68MAPK130.89918792
69PRKCE0.89838881
70MAPKAPK50.88921327
71BRAF0.88673163
72IRAK20.86709425
73PTK2B0.84701125
74MET0.83867317
75CSNK1A1L0.81549659
76RPS6KA50.80821895
77LATS10.80591139
78CHEK10.79217804
79MAP3K70.78489762
80PIM10.77169327
81MAP3K80.75615116
82CDK40.74590554
83NEK10.74526214
84ITK0.73256207
85CSNK2A20.71981733
86ATM0.70755196
87DAPK20.70416522
88CSNK2A10.70237580
89FER0.70194323
90MAP2K60.70136240
91DYRK20.67984232
92DAPK10.67324792
93TNK20.66988791
94YES10.66925026
95TNIK0.66358192
96PRKCG0.66328063
97ERBB40.65988915
98GRK70.65881784
99MKNK20.63730198
100STK100.62792096
101MAPK150.62433500
102ERBB30.62205412
103IKBKB0.61466869
104PAK30.61382105
105MAP3K40.61172899
106KDR0.61137124
107CDK30.60768142
108TXK0.60283079
109TEC0.60276847
110PIK3CA0.59837361
111PRKCI0.59757109
112CSNK1G20.58692677
113GRK10.58219031
114MAP3K110.58029611
115CDK20.56345100
116TRIM280.55254496
117NEK60.53232034
118ADRBK10.52000754
119STK38L0.51609321
120CDK90.50936928
121EPHA40.50923181
122CSNK1A10.50441096
123BTK0.48013167
124BLK0.46760304
125PIK3CG0.45962081
126BCR0.45399197
127OXSR10.44601973
128CDK190.40947925
129CDK10.40767360
130PRKAA10.40212874
131MUSK0.40075152
132PRKAA20.39511625
133PRPF4B0.39351541
134AKT20.39197918
135MAP4K10.37791088
136PAK40.36400070
137OBSCN0.36077102
138TGFBR10.35635028
139MAPK110.34984766
140TAF10.34825672
141BRSK10.34723498
142IGF1R0.32787350
143ABL20.32419035
144PKN10.31248849
145PRKCQ0.30661428
146PAK10.30466814
147BMPR20.29724343
148MAP2K20.29089731
149CSNK1E0.28918352
150MAPK70.28086007
151MAP3K60.27539994
152MAPK40.25976484
153TIE10.24926117

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.60773282
2DNA replication_Homo sapiens_hsa030303.55830417
3Mismatch repair_Homo sapiens_hsa034303.31996542
4RNA polymerase_Homo sapiens_hsa030202.87113550
5One carbon pool by folate_Homo sapiens_hsa006702.63492208
6Homologous recombination_Homo sapiens_hsa034402.56158645
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.54148619
8Proteasome_Homo sapiens_hsa030502.34908135
9Pyrimidine metabolism_Homo sapiens_hsa002402.20591158
10Nucleotide excision repair_Homo sapiens_hsa034202.13973530
11Base excision repair_Homo sapiens_hsa034102.08666695
12Fanconi anemia pathway_Homo sapiens_hsa034602.04670150
13Spliceosome_Homo sapiens_hsa030402.00103226
14Folate biosynthesis_Homo sapiens_hsa007901.91897801
15Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.88222303
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.85505268
17Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.83427630
18Phototransduction_Homo sapiens_hsa047441.78523682
19Non-homologous end-joining_Homo sapiens_hsa034501.76390522
20Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.69976684
21Oxidative phosphorylation_Homo sapiens_hsa001901.62027014
22RNA transport_Homo sapiens_hsa030131.61545709
23Nitrogen metabolism_Homo sapiens_hsa009101.56749551
24Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.48720666
25Basal transcription factors_Homo sapiens_hsa030221.47640336
26Parkinsons disease_Homo sapiens_hsa050121.40872526
27Cyanoamino acid metabolism_Homo sapiens_hsa004601.37997763
28Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.32613452
29Glutathione metabolism_Homo sapiens_hsa004801.30200513
30RNA degradation_Homo sapiens_hsa030181.29630140
31Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.29077486
32Drug metabolism - other enzymes_Homo sapiens_hsa009831.26648022
33Caffeine metabolism_Homo sapiens_hsa002321.26325633
34Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.26090337
35Peroxisome_Homo sapiens_hsa041461.24904606
36Histidine metabolism_Homo sapiens_hsa003401.24808785
37Cell cycle_Homo sapiens_hsa041101.24575814
38Primary bile acid biosynthesis_Homo sapiens_hsa001201.22134096
39Cysteine and methionine metabolism_Homo sapiens_hsa002701.17203223
40Purine metabolism_Homo sapiens_hsa002301.17141683
41Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.15539859
42Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.14672641
43Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.14424862
44Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.13666151
45Huntingtons disease_Homo sapiens_hsa050161.12211581
46Arginine and proline metabolism_Homo sapiens_hsa003301.11410783
47Fatty acid elongation_Homo sapiens_hsa000621.08324105
48Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.08236124
49Biosynthesis of amino acids_Homo sapiens_hsa012301.05094810
502-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.04413459
51Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.03092702
52Protein export_Homo sapiens_hsa030601.02845922
53Linoleic acid metabolism_Homo sapiens_hsa005911.02641388
54beta-Alanine metabolism_Homo sapiens_hsa004101.01864125
55Selenocompound metabolism_Homo sapiens_hsa004501.01467802
56Sulfur relay system_Homo sapiens_hsa041220.98615491
57Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.97663970
58Chemical carcinogenesis_Homo sapiens_hsa052040.97334538
59Pentose and glucuronate interconversions_Homo sapiens_hsa000400.96958079
60Vitamin digestion and absorption_Homo sapiens_hsa049770.95406153
61alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.94526171
62Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.93557244
63Propanoate metabolism_Homo sapiens_hsa006400.93454440
64Tryptophan metabolism_Homo sapiens_hsa003800.92710220
65Arachidonic acid metabolism_Homo sapiens_hsa005900.90982953
66Retinol metabolism_Homo sapiens_hsa008300.90982272
67Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.90739741
68SNARE interactions in vesicular transport_Homo sapiens_hsa041300.90281777
69Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.88052492
70p53 signaling pathway_Homo sapiens_hsa041150.87816737
71Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.87705956
72Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.86165761
73N-Glycan biosynthesis_Homo sapiens_hsa005100.84930532
74Glycerolipid metabolism_Homo sapiens_hsa005610.84220380
75Tyrosine metabolism_Homo sapiens_hsa003500.82284854
76Fatty acid degradation_Homo sapiens_hsa000710.81549676
77Carbon metabolism_Homo sapiens_hsa012000.81055286
78Pentose phosphate pathway_Homo sapiens_hsa000300.80871014
79Metabolic pathways_Homo sapiens_hsa011000.80741759
80Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.78900562
81Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.77334723
82Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.76325402
83Phenylalanine metabolism_Homo sapiens_hsa003600.73597021
84Pyruvate metabolism_Homo sapiens_hsa006200.72438609
85Steroid hormone biosynthesis_Homo sapiens_hsa001400.71858943
86Alzheimers disease_Homo sapiens_hsa050100.71534767
87Steroid biosynthesis_Homo sapiens_hsa001000.70489506
88Arginine biosynthesis_Homo sapiens_hsa002200.69542315
89Vitamin B6 metabolism_Homo sapiens_hsa007500.69522582
90Olfactory transduction_Homo sapiens_hsa047400.69261095
91Fatty acid biosynthesis_Homo sapiens_hsa000610.69223303
92Systemic lupus erythematosus_Homo sapiens_hsa053220.68388603
93Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.65086611
94Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.61539404
95Complement and coagulation cascades_Homo sapiens_hsa046100.56715293
96Butanoate metabolism_Homo sapiens_hsa006500.51815271
97Other glycan degradation_Homo sapiens_hsa005110.51408189
98Sulfur metabolism_Homo sapiens_hsa009200.49059090
99mRNA surveillance pathway_Homo sapiens_hsa030150.48785673
100ABC transporters_Homo sapiens_hsa020100.47451730
101Epstein-Barr virus infection_Homo sapiens_hsa051690.45787232
102Glycerophospholipid metabolism_Homo sapiens_hsa005640.45611248
103Salivary secretion_Homo sapiens_hsa049700.44865638
104Taste transduction_Homo sapiens_hsa047420.44260617
105Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.44183584
106Ether lipid metabolism_Homo sapiens_hsa005650.42599119
107Fat digestion and absorption_Homo sapiens_hsa049750.42441150
108Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.42370651
109Regulation of autophagy_Homo sapiens_hsa041400.40849873
110Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.38906970
111Maturity onset diabetes of the young_Homo sapiens_hsa049500.37547171
112Starch and sucrose metabolism_Homo sapiens_hsa005000.37241300
113Fatty acid metabolism_Homo sapiens_hsa012120.35976819
114Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.35454006
115Fructose and mannose metabolism_Homo sapiens_hsa000510.33311651
116Primary immunodeficiency_Homo sapiens_hsa053400.33236465
117Herpes simplex infection_Homo sapiens_hsa051680.31297540
118Lysine degradation_Homo sapiens_hsa003100.29727515

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