ACP7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Purple acid phosphatases (PAPs), including PAPL, are a family of binuclear metallohydrolases that have been identified in plants, animals, and fungi (Flanagan et al., 2006 [PubMed 16793224]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of skin barrier (GO:0061436)9.58315435
2desmosome organization (GO:0002934)9.20902208
3intermediate filament organization (GO:0045109)8.50517792
4regulation of water loss via skin (GO:0033561)8.47598575
5peptide cross-linking (GO:0018149)7.51039711
6adhesion of symbiont to host cell (GO:0044650)7.28131415
7virion attachment to host cell (GO:0019062)7.28131415
8keratinocyte differentiation (GO:0030216)6.58575430
9adhesion of symbiont to host (GO:0044406)6.45841755
10hemidesmosome assembly (GO:0031581)6.04437789
11epidermal cell differentiation (GO:0009913)5.38904775
12multicellular organismal water homeostasis (GO:0050891)5.38191116
13skin morphogenesis (GO:0043589)5.35053845
14epidermis development (GO:0008544)5.17693466
15intermediate filament cytoskeleton organization (GO:0045104)5.08364443
16citrulline biosynthetic process (GO:0019240)4.93622428
17intermediate filament-based process (GO:0045103)4.91347030
18hair follicle morphogenesis (GO:0031069)4.80730981
19bundle of His cell to Purkinje myocyte communication (GO:0086069)4.70047079
20positive regulation of interleukin-8 secretion (GO:2000484)4.66798786
21positive regulation of meiotic cell cycle (GO:0051446)4.60604882
22water homeostasis (GO:0030104)4.33879853
23ectoderm development (GO:0007398)4.32141878
24regulation of meiosis I (GO:0060631)4.29519452
25DNA deamination (GO:0045006)4.15356947
26behavioral response to nicotine (GO:0035095)4.12467656
27L-fucose catabolic process (GO:0042355)4.06438767
28fucose catabolic process (GO:0019317)4.06438767
29L-fucose metabolic process (GO:0042354)4.06438767
30response to pheromone (GO:0019236)4.02794500
31negative regulation of telomere maintenance (GO:0032205)3.96413669
32regulation of interleukin-8 secretion (GO:2000482)3.91256879
33positive regulation of glomerulus development (GO:0090193)3.87797318
34fatty acid elongation (GO:0030497)3.83025543
35protein K11-linked deubiquitination (GO:0035871)3.80401755
36positive regulation of T-helper 1 type immune response (GO:0002827)3.78457010
37negative regulation of mast cell activation (GO:0033004)3.77705225
38long-chain fatty acid biosynthetic process (GO:0042759)3.63454576
39platelet dense granule organization (GO:0060155)3.62189265
40phosphatidylcholine acyl-chain remodeling (GO:0036151)3.61564026
41regulation of hair cycle (GO:0042634)3.52824437
42cytoskeletal anchoring at plasma membrane (GO:0007016)3.49810554
43defense response to fungus (GO:0050832)3.49273645
44positive regulation of T cell chemotaxis (GO:0010820)3.47047548
45regulation of T cell chemotaxis (GO:0010819)3.47047548
46positive regulation of meiosis (GO:0045836)3.45421225
47detection of light stimulus involved in visual perception (GO:0050908)3.45300268
48detection of light stimulus involved in sensory perception (GO:0050962)3.45300268
49hair cycle process (GO:0022405)3.40107763
50molting cycle process (GO:0022404)3.40107763
51piRNA metabolic process (GO:0034587)3.39781176
52cytidine deamination (GO:0009972)3.37491771
53cytidine metabolic process (GO:0046087)3.37491771
54cytidine catabolic process (GO:0006216)3.37491771
55adaptation of signaling pathway (GO:0023058)3.22897259
56regulation of cell proliferation involved in kidney development (GO:1901722)3.21851356
57regulation of natural killer cell differentiation (GO:0032823)3.20673860
58axoneme assembly (GO:0035082)3.18711779
59oocyte development (GO:0048599)3.13272414
60bone trabecula formation (GO:0060346)3.12684318
61regulation of keratinocyte differentiation (GO:0045616)3.12386474
62sex differentiation (GO:0007548)3.11790721
63sex determination (GO:0007530)3.10752676
64peptidyl-arginine modification (GO:0018195)3.08586216
65cellular ketone body metabolic process (GO:0046950)3.08088028
66citrulline metabolic process (GO:0000052)3.06760562
67tooth mineralization (GO:0034505)3.05507598
68phosphatidylinositol acyl-chain remodeling (GO:0036149)3.02343415
69hair cycle (GO:0042633)21.3090436
70molting cycle (GO:0042303)21.3090436
71pyrimidine ribonucleoside catabolic process (GO:0046133)2.99593795
72negative regulation of neurological system process (GO:0031645)2.99035829
73cell wall macromolecule metabolic process (GO:0044036)2.96865917
74cell wall macromolecule catabolic process (GO:0016998)2.96865917
75glycerophospholipid catabolic process (GO:0046475)2.95974352
76indolalkylamine catabolic process (GO:0046218)2.95852190
77tryptophan catabolic process (GO:0006569)2.95852190
78indole-containing compound catabolic process (GO:0042436)2.95852190
79synaptonemal complex organization (GO:0070193)2.90843005
80preassembly of GPI anchor in ER membrane (GO:0016254)2.90161314
81regulation of cardioblast differentiation (GO:0051890)2.89845856
82indolalkylamine metabolic process (GO:0006586)2.89670871
83detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.87648831
84regulation of glomerulus development (GO:0090192)2.87453268
85rRNA catabolic process (GO:0016075)2.85662904
86regulation of T-helper 1 type immune response (GO:0002825)2.85611909
87regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.83465845
88vitamin transmembrane transport (GO:0035461)2.82977041
89parturition (GO:0007567)2.82179350
90phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.81128129
91cell-substrate junction assembly (GO:0007044)2.81052003
92ketone body metabolic process (GO:1902224)2.79778002
93phosphatidylserine acyl-chain remodeling (GO:0036150)2.79701667
94tryptophan metabolic process (GO:0006568)2.79210027
95positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)2.73219812
96regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)2.73219812
97GPI anchor metabolic process (GO:0006505)2.72650582
98water-soluble vitamin biosynthetic process (GO:0042364)2.72387184
99lipoxygenase pathway (GO:0019372)2.67984767
100keratinocyte development (GO:0003334)2.67874026
101atrioventricular valve morphogenesis (GO:0003181)2.67650438
102ephrin receptor signaling pathway (GO:0048013)2.66635820
103positive regulation of male gonad development (GO:2000020)2.65768884
104anterior/posterior axis specification, embryo (GO:0008595)2.63688450
105cornea development in camera-type eye (GO:0061303)2.63631672
106defense response to Gram-negative bacterium (GO:0050829)2.63372925
107synaptonemal complex assembly (GO:0007130)2.61079300
108positive regulation of cellular amide metabolic process (GO:0034250)2.59037757
109positive regulation of humoral immune response (GO:0002922)2.58656111
110negative regulation of cell fate specification (GO:0009996)2.58530780
111male meiosis (GO:0007140)2.58417116
112photoreceptor cell maintenance (GO:0045494)2.55621563
113mitotic G1/S transition checkpoint (GO:0044819)2.55126492
114response to fungus (GO:0009620)2.54399745
115ceramide biosynthetic process (GO:0046513)2.52159741
116negative regulation of catenin import into nucleus (GO:0035414)2.50712777
117regulation of transforming growth factor beta1 production (GO:0032908)2.49550049
118regulation of glucokinase activity (GO:0033131)2.48884310
119regulation of hexokinase activity (GO:1903299)2.48884310
120gonadal mesoderm development (GO:0007506)2.47759275
121ventricular cardiac muscle cell action potential (GO:0086005)2.47734290
122regulation of telomere maintenance (GO:0032204)2.46309410
123regulation of MHC class I biosynthetic process (GO:0045343)2.45111664
124axon ensheathment (GO:0008366)2.44895175
125ensheathment of neurons (GO:0007272)2.44895175
126magnesium ion transport (GO:0015693)2.44105713
127astrocyte development (GO:0014002)2.43777886
128keratinocyte proliferation (GO:0043616)2.43762449
129natural killer cell activation involved in immune response (GO:0002323)2.43600113
130glial cell proliferation (GO:0014009)2.43105035
131phosphatidylserine metabolic process (GO:0006658)2.42978911
132positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.42265323
133skin development (GO:0043588)2.40895096
134epithelial cell-cell adhesion (GO:0090136)2.39515529
135mannosylation (GO:0097502)2.38812973
136G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.38133297
137GPI anchor biosynthetic process (GO:0006506)2.37660620
138adenosine metabolic process (GO:0046085)2.36942865
139DNA methylation involved in gamete generation (GO:0043046)2.36855994
140epithelium development (GO:0060429)2.36457339
141positive regulation of oligodendrocyte differentiation (GO:0048714)2.36270154
142epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.35082949
143amine catabolic process (GO:0009310)2.35069677
144cellular biogenic amine catabolic process (GO:0042402)2.35069677
145fusion of sperm to egg plasma membrane (GO:0007342)2.34688889
146branching involved in labyrinthine layer morphogenesis (GO:0060670)2.34245689
147epithelial cilium movement (GO:0003351)2.33959001
148regulation of male gonad development (GO:2000018)2.32371140
149negative regulation of JUN kinase activity (GO:0043508)2.30957144
150hair follicle development (GO:0001942)2.30709798
151myelination (GO:0042552)2.30000129
152regulation of ruffle assembly (GO:1900027)2.28972090
153phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.28179788
154anatomical structure regression (GO:0060033)2.27218784
155regulation of translational termination (GO:0006449)2.27073784
156negative regulation of inclusion body assembly (GO:0090084)2.26364891
157long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.26311819
158long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.26122736
159embryonic camera-type eye development (GO:0031076)2.24980655
160negative regulation of epidermis development (GO:0045683)2.24428378
161cellular response to arsenic-containing substance (GO:0071243)2.23543336
162establishment of planar polarity (GO:0001736)2.23463766
163establishment of tissue polarity (GO:0007164)2.23463766
164dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.20851565
165regulation of epidermal cell differentiation (GO:0045604)2.20523664
166negative regulation of neurotransmitter secretion (GO:0046929)2.19946502
167planar cell polarity pathway involved in neural tube closure (GO:0090179)2.19459577
168male meiosis I (GO:0007141)2.19133924
169ovulation cycle (GO:0042698)2.17671328
170cellular component disassembly involved in execution phase of apoptosis (GO:0006921)2.17487975
171keratinization (GO:0031424)14.4794818

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.64313573
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.45386997
3VDR_22108803_ChIP-Seq_LS180_Human3.24388531
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.21933006
5P63_26484246_Chip-Seq_KERATINOCYTES_Human3.07046497
6CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.82558043
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.81988323
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.61119990
9IGF1R_20145208_ChIP-Seq_DFB_Human2.60897171
10ZNF263_19887448_ChIP-Seq_K562_Human2.57921108
11ZFP57_27257070_Chip-Seq_ESCs_Mouse2.42082957
12GBX2_23144817_ChIP-Seq_PC3_Human2.37787471
13ESR2_21235772_ChIP-Seq_MCF-7_Human2.26741351
14STAT6_21828071_ChIP-Seq_BEAS2B_Human2.23628352
15ESR1_21235772_ChIP-Seq_MCF-7_Human2.06305008
16NOTCH1_21737748_ChIP-Seq_TLL_Human2.00697852
17TP63_17297297_ChIP-ChIP_HaCaT_Human10.9198462
18POU3F2_20337985_ChIP-ChIP_501MEL_Human1.97301272
19CTBP2_25329375_ChIP-Seq_LNCAP_Human1.90874815
20FOXO3_23340844_ChIP-Seq_DLD1_Human1.89464041
21EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.87548562
22SOX9_24532713_ChIP-Seq_HFSC_Mouse1.81441240
23NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.80550672
24FLI1_27457419_Chip-Seq_LIVER_Mouse1.79518072
25SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.78062346
26TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.77057972
27ER_23166858_ChIP-Seq_MCF-7_Human1.75218782
28CTCF_27219007_Chip-Seq_Bcells_Human1.74707025
29BCAT_22108803_ChIP-Seq_LS180_Human1.74089226
30GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.72963130
31HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.71137294
32TAF15_26573619_Chip-Seq_HEK293_Human1.70776068
33CTBP1_25329375_ChIP-Seq_LNCAP_Human1.70063892
34ATF3_27146783_Chip-Seq_COLON_Human1.66943485
35RACK7_27058665_Chip-Seq_MCF-7_Human1.66216191
36CTCF_20526341_ChIP-Seq_ESCs_Human1.64342272
37GATA3_21878914_ChIP-Seq_MCF-7_Human1.62047774
38FOXA1_25329375_ChIP-Seq_VCAP_Human1.60212563
39FOXA1_27270436_Chip-Seq_PROSTATE_Human1.60212563
40PCGF2_27294783_Chip-Seq_NPCs_Mouse1.59995911
41CBP_20019798_ChIP-Seq_JUKART_Human1.58763012
42IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.58763012
43P300_19829295_ChIP-Seq_ESCs_Human1.58541111
44SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.57302065
45SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.57302065
46ERG_21242973_ChIP-ChIP_JURKAT_Human1.57120950
47DNAJC2_21179169_ChIP-ChIP_NT2_Human1.57045039
48AR_20517297_ChIP-Seq_VCAP_Human1.56417042
49PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.56078083
50KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.54868173
51PCGF2_27294783_Chip-Seq_ESCs_Mouse1.51266801
52RUNX1_27514584_Chip-Seq_MCF-7_Human1.48154857
53AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.47473580
54TP53_22573176_ChIP-Seq_HFKS_Human1.46445859
55TCF4_22108803_ChIP-Seq_LS180_Human1.46028835
56AR_25329375_ChIP-Seq_VCAP_Human1.45028852
57FUS_26573619_Chip-Seq_HEK293_Human1.43372664
58EWS_26573619_Chip-Seq_HEK293_Human1.43167277
59NCOR_22424771_ChIP-Seq_293T_Human1.42989051
60TP63_22573176_ChIP-Seq_HFKS_Human1.42606513
61CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.41091026
62NR3C1_21868756_ChIP-Seq_MCF10A_Human1.40827112
63NANOG_19829295_ChIP-Seq_ESCs_Human1.40256961
64SOX2_19829295_ChIP-Seq_ESCs_Human1.40256961
65KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.39885055
66KDM2B_26808549_Chip-Seq_K562_Human1.39693823
67AUTS2_25519132_ChIP-Seq_293T-REX_Human1.39309492
68GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.39053112
69STAT3_23295773_ChIP-Seq_U87_Human1.39026797
70GATA3_26560356_Chip-Seq_TH2_Human1.38071113
71ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.37476702
72SMAD4_21799915_ChIP-Seq_A2780_Human1.37434065
73EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.36376856
74KLF5_25053715_ChIP-Seq_YYC3_Human1.35671200
75EGR1_23403033_ChIP-Seq_LIVER_Mouse1.35131045
76FOXA1_21572438_ChIP-Seq_LNCaP_Human1.35023265
77P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.34338381
78SUZ12_27294783_Chip-Seq_NPCs_Mouse1.33732113
79KLF5_20875108_ChIP-Seq_MESCs_Mouse1.33680798
80UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.33614724
81P300_27058665_Chip-Seq_ZR-75-30cells_Human1.33542091
82EGR1_19032775_ChIP-ChIP_M12_Human1.33214398
83NFE2_27457419_Chip-Seq_LIVER_Mouse1.33186591
84UBF1/2_26484160_Chip-Seq_HMECs_Human1.32336830
85UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.31958878
86AHR_22903824_ChIP-Seq_MCF-7_Human1.31583884
87GABP_17652178_ChIP-ChIP_JURKAT_Human1.31338002
88EZH2_27294783_Chip-Seq_NPCs_Mouse1.29487782
89CDX2_22108803_ChIP-Seq_LS180_Human1.28489561
90GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.27888289
91TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27685837
92POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.27685837
93TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.25907453
94TCF4_23295773_ChIP-Seq_U87_Human1.25449240
95ZNF217_24962896_ChIP-Seq_MCF-7_Human1.25365555
96KDM2B_26808549_Chip-Seq_DND41_Human1.24588486
97IRF1_19129219_ChIP-ChIP_H3396_Human1.24442267
98HIF1A_21447827_ChIP-Seq_MCF-7_Human1.23682821
99ARNT_22903824_ChIP-Seq_MCF-7_Human1.23286208
100CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.23193094
101ZFP281_18757296_ChIP-ChIP_E14_Mouse1.22941615
102ETV2_25802403_ChIP-Seq_MESCs_Mouse1.22770445
103KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.21857715
104HOXB7_26014856_ChIP-Seq_BT474_Human1.21557956
105RXR_22108803_ChIP-Seq_LS180_Human1.21462078
106IRF8_22096565_ChIP-ChIP_GC-B_Human1.20627056
107E2F1_20622854_ChIP-Seq_HELA_Human1.20421145
108MYC_18940864_ChIP-ChIP_HL60_Human1.20251041
109PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.19945785
110MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.19538484
111CDX2_19796622_ChIP-Seq_MESCs_Mouse1.19493590
112GATA3_24758297_ChIP-Seq_MCF-7_Human1.19162631
113WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.19021818
114SALL1_21062744_ChIP-ChIP_HESCs_Human1.18981500
115RBPJ_21746931_ChIP-Seq_IB4_Human1.18928084
116SMAD4_21741376_ChIP-Seq_EPCs_Human1.18909759
117LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.16990881
118EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.16695310
119LXR_22292898_ChIP-Seq_THP-1_Human1.16576089
120CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.16330756
121PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.16270361
122TP63_23658742_ChIP-Seq_EP156T_Human1.15994685
123GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.15746936
124PIAS1_25552417_ChIP-Seq_VCAP_Human1.15197404
125FOXH1_21741376_ChIP-Seq_EPCs_Human1.15127533
126MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.14809508
127TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.13427413
128ERG_20517297_ChIP-Seq_VCAP_Human1.12525854
129SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.11763986
130TRIM28_21343339_ChIP-Seq_HEK293_Human1.10678539
131TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.10590764
132IKZF1_21737484_ChIP-ChIP_HCT116_Human1.10538079
133GATA6_21074721_ChIP-Seq_CACO-2_Human1.10085063
134CLOCK_20551151_ChIP-Seq_293T_Human1.10072517
135SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.10011113
136SA1_27219007_Chip-Seq_ERYTHROID_Human1.09657695
137SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.09601682
138SMAD3_21741376_ChIP-Seq_EPCs_Human1.09481836
139CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.09404747
140RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.08672239
141ERA_21632823_ChIP-Seq_H3396_Human1.06877047
142CSB_26484114_Chip-Seq_FIBROBLAST_Human1.06671532
143TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.06339977
144SUZ12_27294783_Chip-Seq_ESCs_Mouse1.06179708
145CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.06120061
146TCF4_18268006_ChIP-ChIP_LS174T_Human1.06093142
147VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.05709374
148EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.04907917
149RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04734464
150NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.04282447
151CRX_20693478_ChIP-Seq_RETINA_Mouse1.03765462
152PRDM14_20953172_ChIP-Seq_ESCs_Human1.03422792
153RARG_19884340_ChIP-ChIP_MEFs_Mouse1.02874897
154OCT4_20526341_ChIP-Seq_ESCs_Human1.02727950
155NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.02629244
156NANOG_20526341_ChIP-Seq_ESCs_Human1.02373165
157YY1_22570637_ChIP-Seq_MALME-3M_Human1.02208316
158JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02003400
159KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.01688178
160KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.01688178
161KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.01688178
162P53_21459846_ChIP-Seq_SAOS-2_Human1.01335149
163BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.00786609
164JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.00525946
165TP53_20018659_ChIP-ChIP_R1E_Mouse0.99165401
166SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.97593421
167BCOR_27268052_Chip-Seq_Bcells_Human0.97481749
168KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.96148700
169SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.95904691
170SMC4_20622854_ChIP-Seq_HELA_Human0.94749263
171KDM2B_26808549_Chip-Seq_JURKAT_Human0.93863781
172SOX2_21211035_ChIP-Seq_LN229_Human0.91524249
173TAF2_19829295_ChIP-Seq_ESCs_Human0.88430566
174CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.87854227
175FOXH1_21741376_ChIP-Seq_ESCs_Human0.87409759
176KDM2B_26808549_Chip-Seq_SUP-B15_Human0.86625774
177P68_20966046_ChIP-Seq_HELA_Human0.85870408
178EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.85559454
179TP53_16413492_ChIP-PET_HCT116_Human0.85411651
180ELK3_25401928_ChIP-Seq_HUVEC_Human0.85335753
181GATA4_25053715_ChIP-Seq_YYC3_Human0.85215158
182RNF2_27304074_Chip-Seq_ESCs_Mouse0.85193190
183TCF7_22412390_ChIP-Seq_EML_Mouse0.85149740
184SOX2_20726797_ChIP-Seq_SW620_Human0.84654733
185CJUN_26792858_Chip-Seq_BT549_Human0.84385806
186ZFP281_27345836_Chip-Seq_ESCs_Mouse0.83260254
187MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse0.83068746
188SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.81470981
189GATA6_25053715_ChIP-Seq_YYC3_Human0.80013288

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier6.66202530
2MP0000579_abnormal_nail_morphology5.94495453
3MP0010234_abnormal_vibrissa_follicle5.84230033
4MP0005275_abnormal_skin_tensile5.40479587
5MP0002098_abnormal_vibrissa_morphology4.75141732
6MP0000647_abnormal_sebaceous_gland4.41953650
7MP0010678_abnormal_skin_adnexa4.38920898
8MP0000383_abnormal_hair_follicle4.33172518
9MP0005501_abnormal_skin_physiology4.09606781
10MP0003705_abnormal_hypodermis_morpholog3.21202381
11MP0000377_abnormal_hair_follicle2.79689949
12MP0004381_abnormal_hair_follicle2.68736207
13MP0001216_abnormal_epidermal_layer2.68284154
14MP0004947_skin_inflammation2.67211239
15MP0000427_abnormal_hair_cycle2.48934711
16MP0010771_integument_phenotype2.46434248
17MP0003453_abnormal_keratinocyte_physiol2.36350175
18MP0002060_abnormal_skin_morphology2.32980874
19MP0002102_abnormal_ear_morphology2.32010208
20MP0003941_abnormal_skin_development2.26923514
21MP0003011_delayed_dark_adaptation2.22209253
22MP0003195_calcinosis2.20510285
23MP0006072_abnormal_retinal_apoptosis2.12278441
24MP0005551_abnormal_eye_electrophysiolog2.11471180
25MP0002254_reproductive_system_inflammat2.06441185
26MP0004043_abnormal_pH_regulation2.02275355
27MP0000372_irregular_coat_pigmentation1.92029087
28MP0000569_abnormal_digit_pigmentation1.85322033
29MP0005377_hearing/vestibular/ear_phenot1.83975256
30MP0003878_abnormal_ear_physiology1.83975256
31MP0002877_abnormal_melanocyte_morpholog1.80247914
32MP0005646_abnormal_pituitary_gland1.79528511
33MP0008872_abnormal_physiological_respon1.77666638
34MP0008995_early_reproductive_senescence1.77168931
35MP0005451_abnormal_body_composition1.74326673
36MP0000467_abnormal_esophagus_morphology1.72087714
37MP0002876_abnormal_thyroid_physiology1.71727052
38MP0008875_abnormal_xenobiotic_pharmacok1.68402210
39MP0001851_eye_inflammation1.63191021
40MP0001968_abnormal_touch/_nociception1.63105580
41MP0002095_abnormal_skin_pigmentation1.62796728
42MP0003787_abnormal_imprinting1.57110903
43MP0003646_muscle_fatigue1.57081489
44MP0000367_abnormal_coat/_hair1.55039111
45MP0004885_abnormal_endolymph1.54336372
46MP0004742_abnormal_vestibular_system1.54026504
47MP0001501_abnormal_sleep_pattern1.53860761
48MP0005253_abnormal_eye_physiology1.53009779
49MP0005075_abnormal_melanosome_morpholog1.52888409
50MP0005174_abnormal_tail_pigmentation1.48751357
51MP0001243_abnormal_dermal_layer1.47739655
52MP0009745_abnormal_behavioral_response1.45281328
53MP0009931_abnormal_skin_appearance1.44023312
54MP0003566_abnormal_cell_adhesion1.42702419
55MP0000762_abnormal_tongue_morphology1.42680173
56MP0008877_abnormal_DNA_methylation1.40594161
57MP0004185_abnormal_adipocyte_glucose1.38497227
58MP0002736_abnormal_nociception_after1.36198209
59MP0002234_abnormal_pharynx_morphology1.35468992
60MP0002163_abnormal_gland_morphology1.35286277
61MP0000015_abnormal_ear_pigmentation1.30762419
62MP0010386_abnormal_urinary_bladder1.26589247
63MP0009046_muscle_twitch1.24643268
64MP0001849_ear_inflammation1.21397246
65MP0002638_abnormal_pupillary_reflex1.18951914
66MP0005645_abnormal_hypothalamus_physiol1.15767551
67MP0004133_heterotaxia1.14696553
68MP0002138_abnormal_hepatobiliary_system1.11304508
69MP0006276_abnormal_autonomic_nervous1.09210018
70MP0001984_abnormal_olfaction1.07541243
71MP0006292_abnormal_olfactory_placode1.07421715
72MP0005671_abnormal_response_to1.05665276
73MP0009053_abnormal_anal_canal1.05631694
74MP0000537_abnormal_urethra_morphology1.05410824
75MP0002653_abnormal_ependyma_morphology1.04273348
76MP0003136_yellow_coat_color1.03524611
77MP0003315_abnormal_perineum_morphology1.01785697
78MP0005389_reproductive_system_phenotype1.01416371
79MP0001919_abnormal_reproductive_system1.01152078
80MP0002909_abnormal_adrenal_gland0.99363720
81MP0002837_dystrophic_cardiac_calcinosis0.96647597
82MP0009780_abnormal_chondrocyte_physiolo0.96460427
83MP0001191_abnormal_skin_condition0.95871152
84MP0002272_abnormal_nervous_system0.95801460
85MP0008058_abnormal_DNA_repair0.95323910
86MP0004264_abnormal_extraembryonic_tissu0.92314872
87MP0005379_endocrine/exocrine_gland_phen0.91216211
88MP0003880_abnormal_central_pattern0.90765265
89MP0001346_abnormal_lacrimal_gland0.89707246
90MP0005410_abnormal_fertilization0.88435519
91MP0001340_abnormal_eyelid_morphology0.87717465
92MP0009384_cardiac_valve_regurgitation0.85896627
93MP0002572_abnormal_emotion/affect_behav0.84886916
94MP0001986_abnormal_taste_sensitivity0.83864110
95MP0005248_abnormal_Harderian_gland0.82372154
96MP0002733_abnormal_thermal_nociception0.81945846
97MP0008438_abnormal_cutaneous_collagen0.81529232
98MP0001727_abnormal_embryo_implantation0.78223472
99MP0001502_abnormal_circadian_rhythm0.78210617
100MP0002064_seizures0.75231225
101MP0003329_amyloid_beta_deposits0.73926716
102MP0001970_abnormal_pain_threshold0.73106552
103MP0002009_preneoplasia0.72697555
104MP0004272_abnormal_basement_membrane0.71720307
105MP0005310_abnormal_salivary_gland0.71609970
106MP0002693_abnormal_pancreas_physiology0.70591854
107MP0005409_darkened_coat_color0.69862770
108MP0005076_abnormal_cell_differentiation0.69611028
109MP0001764_abnormal_homeostasis0.69531711
110MP0002160_abnormal_reproductive_system0.69487195
111MP0001661_extended_life_span0.69247410
112MP0003191_abnormal_cellular_cholesterol0.69221636
113MP0000230_abnormal_systemic_arterial0.68090474
114MP0001486_abnormal_startle_reflex0.67979738
115MP0005332_abnormal_amino_acid0.67218443
116MP0005666_abnormal_adipose_tissue0.67051075
117MP0001784_abnormal_fluid_regulation0.65877246
118MP0001905_abnormal_dopamine_level0.65522105
119MP0002938_white_spotting0.64034654
120MP0004924_abnormal_behavior0.62735823
121MP0005386_behavior/neurological_phenoty0.62735823
122MP0003045_fibrosis0.62283818
123MP0003879_abnormal_hair_cell0.61592426
124MP0000613_abnormal_salivary_gland0.61546833
125MP0000631_abnormal_neuroendocrine_gland0.60209527
126MP0005623_abnormal_meninges_morphology0.60132160
127MP0002557_abnormal_social/conspecific_i0.59336502
128MP0004782_abnormal_surfactant_physiolog0.59133520
129MP0005375_adipose_tissue_phenotype0.57527532
130MP0005171_absent_coat_pigmentation0.56241932
131MP0001485_abnormal_pinna_reflex0.53268890
132MP0000627_abnormal_mammary_gland0.53247469
133MP0005023_abnormal_wound_healing0.52966302
134MP0008961_abnormal_basal_metabolism0.51195174
135MP0002210_abnormal_sex_determination0.48582757
136MP0003300_gastrointestinal_ulcer0.47616142
137MP0003755_abnormal_palate_morphology0.44606214
138MP0002111_abnormal_tail_morphology0.38540579
139MP0003786_premature_aging0.37840494
140MP0004147_increased_porphyrin_level0.37171361
141MP0000003_abnormal_adipose_tissue0.35752061
142MP0003950_abnormal_plasma_membrane0.35145802
143MP0003936_abnormal_reproductive_system0.35125188
144MP0001188_hyperpigmentation0.34735216
145MP0001145_abnormal_male_reproductive0.33036135
146MP0001958_emphysema0.32862618
147MP0002177_abnormal_outer_ear0.31344176
148MP0004197_abnormal_fetal_growth/weight/0.31160454
149MP0001929_abnormal_gametogenesis0.29600637
150MP0002282_abnormal_trachea_morphology0.29384570
151MP0003632_abnormal_nervous_system0.29246824
152MP0000747_muscle_weakness0.28883929
153MP0000751_myopathy0.28707285
154MP0003890_abnormal_embryonic-extraembry0.28681853
155MP0004270_analgesia0.28218974
156MP0010352_gastrointestinal_tract_polyps0.27462434
157MP0001348_abnormal_lacrimal_gland0.27207428
158MP0004859_abnormal_synaptic_plasticity0.26438714
159MP0001299_abnormal_eye_distance/0.26030875
160MP0000733_abnormal_muscle_development0.24620465
161MP0003698_abnormal_male_reproductive0.24603283
162MP0000653_abnormal_sex_gland0.24566170
163MP0002697_abnormal_eye_size0.24310727
164MP0002090_abnormal_vision0.23202594
165MP0006138_congestive_heart_failure0.22483345
166MP0000432_abnormal_head_morphology0.21170173

Predicted human phenotypes

RankGene SetZ-score
1Woolly hair (HP:0002224)7.47054595
2Pili torti (HP:0003777)7.05138547
3Abnormality of nail color (HP:0100643)6.94251652
4Parakeratosis (HP:0001036)6.75152602
5Increased IgE level (HP:0003212)6.01493773
6Abnormality of hair growth rate (HP:0011363)5.97494328
7Slow-growing hair (HP:0002217)5.97494328
8Brittle hair (HP:0002299)5.86933877
9Nail dystrophy (HP:0008404)5.57684900
10Palmoplantar hyperkeratosis (HP:0000972)5.13187590
11Congenital ichthyosiform erythroderma (HP:0007431)4.99969538
12Onycholysis (HP:0001806)4.87029436
13Palmar hyperkeratosis (HP:0010765)4.86501328
14Plantar hyperkeratosis (HP:0007556)4.80918493
15Congenital nonbullous ichthyosiform erythroderma (HP:0007479)4.63904050
16Thick nail (HP:0001805)4.62729292
17Erythroderma (HP:0001019)4.61185496
18Fragile nails (HP:0001808)4.44671751
19Abnormal hair laboratory examination (HP:0003328)4.24356138
20Right ventricular cardiomyopathy (HP:0011663)4.20909033
21Alopecia of scalp (HP:0002293)4.15995936
22Milia (HP:0001056)3.59912063
23Erythema (HP:0010783)3.53666413
24Congenital stationary night blindness (HP:0007642)3.49124920
25Follicular hyperkeratosis (HP:0007502)3.46170913
26Corneal erosion (HP:0200020)3.43683133
27Pancreatic cysts (HP:0001737)3.37751388
28Furrowed tongue (HP:0000221)3.37004518
29Ectropion (HP:0000656)3.18126622
30Hypohidrosis (HP:0000966)3.10086682
31Abnormality of midbrain morphology (HP:0002418)3.04282649
32Molar tooth sign on MRI (HP:0002419)3.04282649
33Hyporeflexia of lower limbs (HP:0002600)2.98363201
34Pustule (HP:0200039)2.95890260
35Abnormal blistering of the skin (HP:0008066)2.95552973
36Oral leukoplakia (HP:0002745)2.95271249
37Fine hair (HP:0002213)2.94540250
38Gangrene (HP:0100758)2.94185239
39Male infertility (HP:0003251)2.92247215
40True hermaphroditism (HP:0010459)2.90298121
41Pancreatic fibrosis (HP:0100732)2.83151935
42Sparse eyelashes (HP:0000653)2.76323938
43Nephronophthisis (HP:0000090)2.68198130
44Attenuation of retinal blood vessels (HP:0007843)2.64325779
45Abnormality of the renal cortex (HP:0011035)2.63198164
46Palmoplantar keratoderma (HP:0000982)2.62274748
47Curly hair (HP:0002212)2.48307845
48Ridged nail (HP:0001807)2.44631065
49Pruritus (HP:0000989)2.43934271
50Abnormal drinking behavior (HP:0030082)2.42756754
51Polydipsia (HP:0001959)2.42756754
52Back pain (HP:0003418)2.42510418
53Abnormality of the renal medulla (HP:0100957)2.39843758
54Decreased central vision (HP:0007663)2.36818738
55Tubular atrophy (HP:0000092)2.35286937
56Neck muscle weakness (HP:0000467)2.34499861
57Decreased electroretinogram (ERG) amplitude (HP:0000654)2.29398518
58Ketoacidosis (HP:0001993)2.28049221
59Abnormal rod and cone electroretinograms (HP:0008323)2.25220098
60Abolished electroretinogram (ERG) (HP:0000550)2.23254843
61Degeneration of the lateral corticospinal tracts (HP:0002314)2.22470696
62Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.22470696
63Hamartoma of the eye (HP:0010568)2.19933683
64Concave nail (HP:0001598)2.16852030
65Large for gestational age (HP:0001520)2.15211166
66Lack of skin elasticity (HP:0100679)2.15155410
67Conjunctival hamartoma (HP:0100780)2.13983490
68Distal upper limb amyotrophy (HP:0007149)2.12369672
69Upper limb amyotrophy (HP:0009129)2.12369672
70Ventricular fibrillation (HP:0001663)2.05696356
71Pendular nystagmus (HP:0012043)2.04451781
72Aplasia/hypoplasia of the uterus (HP:0008684)2.04447297
73Keratoconus (HP:0000563)2.03745401
74Increased corneal curvature (HP:0100692)2.03745401
75Insidious onset (HP:0003587)2.03311353
76Termporal pattern (HP:0011008)2.03311353
77Stomach cancer (HP:0012126)2.03267821
78Natal tooth (HP:0000695)2.03149523
79Hand muscle atrophy (HP:0009130)2.01365432
80Hypotrichosis (HP:0001006)10.3715722
81Polyuria (HP:0000103)1.98492923
82Hemiparesis (HP:0001269)1.97744018
83Hypoplasia of the uterus (HP:0000013)1.97090830
84Chronic hepatic failure (HP:0100626)1.97043297
85Cystic liver disease (HP:0006706)1.93367033
86Type II lissencephaly (HP:0007260)1.93057065
87Ankle clonus (HP:0011448)1.92301536
88Exercise-induced myalgia (HP:0003738)1.90454950
89Aplasia/Hypoplasia of the spleen (HP:0010451)1.88224347
90Absent rod-and cone-mediated responses on ERG (HP:0007688)1.87899800
91Neoplasm of the adrenal cortex (HP:0100641)1.87693895
92Advanced eruption of teeth (HP:0006288)1.85584100
93Hypergammaglobulinemia (HP:0010702)1.85473855
94Hypoproteinemia (HP:0003075)1.84855569
95Abnormality of secondary sexual hair (HP:0009888)1.84733152
96Abnormality of the axillary hair (HP:0100134)1.84733152
97Gaze-evoked nystagmus (HP:0000640)1.83379616
98Thyroiditis (HP:0100646)1.83320263
99Ketosis (HP:0001946)1.82305218
100Medial flaring of the eyebrow (HP:0010747)1.80000675
101Hypothermia (HP:0002045)1.79986421
102Severe visual impairment (HP:0001141)1.77738895
103Hypoplasia of the iris (HP:0007676)1.77539580
104Abnormality of the corticospinal tract (HP:0002492)1.76439034
105Atrophic scars (HP:0001075)1.75004361
106Asplenia (HP:0001746)1.74579469
107Ulnar claw (HP:0001178)1.74495058
108Colon cancer (HP:0003003)1.74128303
109Abnormality of the prostate (HP:0008775)1.73314972
110Methylmalonic acidemia (HP:0002912)1.72894240
111Conical tooth (HP:0000698)1.72721782
112Hyperventilation (HP:0002883)1.72131602
113Myopathic facies (HP:0002058)1.72121822
114Epidermoid cyst (HP:0200040)1.71193182
115Renal cortical cysts (HP:0000803)1.70793572
116Dehydration (HP:0001944)1.70173393
117Ventricular tachycardia (HP:0004756)1.70164986
118Amelogenesis imperfecta (HP:0000705)1.68924249
119Recurrent corneal erosions (HP:0000495)1.68587978
120Acanthosis nigricans (HP:0000956)1.67757267
121Increased CSF lactate (HP:0002490)1.67746974
122Abnormality of the frontal sinuses (HP:0002687)1.65704760
123Stomatitis (HP:0010280)1.65424194
124Gonadotropin excess (HP:0000837)1.64836332
125Prostate neoplasm (HP:0100787)1.64610448
126Autoimmune hemolytic anemia (HP:0001890)1.64163784
127Aplasia cutis congenita (HP:0001057)1.63658835
128Muscle fiber splitting (HP:0003555)1.63059334
129Sclerocornea (HP:0000647)1.63006166
130Abnormality of the renal collecting system (HP:0004742)1.62923917
131Peripheral hypomyelination (HP:0007182)1.62137954
132Intention tremor (HP:0002080)1.61296975
133Keratoconjunctivitis (HP:0001096)1.61131651
134Bony spicule pigmentary retinopathy (HP:0007737)1.60868882
135Round ear (HP:0100830)1.60703229
136Hypomagnesemia (HP:0002917)1.60366962
137Areflexia of lower limbs (HP:0002522)1.60272624
138Photophobia (HP:0000613)1.59906826
139Gonadal dysgenesis (HP:0000133)1.59164445
140Macular degeneration (HP:0000608)1.58773366
141Decreased circulating renin level (HP:0003351)1.58395881
142Autoamputation (HP:0001218)1.58112480
143Abnormality of the labia minora (HP:0012880)1.57689022
144Facial diplegia (HP:0001349)1.57540574
145Lip pit (HP:0100267)1.57056527
146Duplicated collecting system (HP:0000081)1.54726773
147Aplasia/Hypoplasia of the fovea (HP:0008060)1.54597485
148Hypoplasia of the fovea (HP:0007750)1.54597485
149Mitochondrial inheritance (HP:0001427)1.54556382
150Torticollis (HP:0000473)1.51530165
151Cerebral inclusion bodies (HP:0100314)1.50662962
152Oligodontia (HP:0000677)1.50603290
153Premature rupture of membranes (HP:0001788)1.50294459
154Increased connective tissue (HP:0009025)1.50233868
155Sparse scalp hair (HP:0002209)1.48070306
156Abnormality of molar morphology (HP:0011070)1.47403278
157Abnormality of molar (HP:0011077)1.47403278
158Achilles tendon contracture (HP:0001771)1.46763610
159Laryngomalacia (HP:0001601)1.44489619
160Abnormality of permanent molar morphology (HP:0011071)1.44167955
161Abnormality of the dental root (HP:0006486)1.44167955
162Taurodontia (HP:0000679)1.44167955
163Diaphragmatic weakness (HP:0009113)1.43016784
164Difficulty running (HP:0009046)1.42331504
165Hyperhidrosis (HP:0000975)1.42115429
166Congenital, generalized hypertrichosis (HP:0004540)1.41757149
167Blepharitis (HP:0000498)1.41039135
168Bronchomalacia (HP:0002780)1.40252153
169Carious teeth (HP:0000670)1.39344362
170Anonychia (HP:0001798)1.37543484

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.86738719
2MAP4K23.76300983
3LATS13.63109164
4MAP3K93.30001523
5TESK23.19441958
6LATS22.95546186
7ADRBK22.71545673
8FER2.70738722
9GRK12.70277205
10ICK2.65571542
11TAOK32.49569900
12TYRO32.48727629
13PKN22.42093773
14TXK2.36702927
15KSR22.34508265
16NUAK12.32666257
17CDK192.30623530
18EPHA22.27844310
19ZAK2.17679686
20EPHB12.16173670
21TAOK12.12228281
22TLK12.10736815
23CDK122.04765686
24PAK62.02685452
25BRD42.01853372
26BMPR1B1.99235064
27PAK31.95585512
28MAPKAPK31.87875575
29MST41.86968776
30TRIB31.86613987
31MAP3K131.74733144
32RPS6KB21.71493959
33OXSR11.70994743
34BCR1.69668857
35TRIM281.66496854
36VRK21.65765560
37MAP2K61.65357038
38RIPK11.61247632
39STK38L1.58572356
40INSRR1.56702423
41NME11.56261882
42PINK11.52455740
43DDR21.49811842
44MAP3K21.39519207
45WNK41.35745675
46BCKDK1.34005021
47FGFR11.27121334
48TAF11.24214052
49ADRBK11.21113542
50EEF2K1.20315174
51MAP3K31.18037218
52MAP3K61.15031080
53IKBKB1.13891682
54MARK31.13849906
55CAMKK21.12931845
56STK381.10438655
57CASK1.08825115
58PTK61.04551039
59TTN1.03720408
60STK31.03697245
61MUSK0.99219097
62MAPK130.98240914
63STK390.97413869
64LIMK10.96754087
65MAPKAPK50.95799821
66BRSK20.95489266
67PRKCE0.95294293
68PAK40.94786136
69PDGFRA0.94056451
70ERBB40.92455037
71MAP2K20.92295358
72CSNK1G10.92005375
73IRAK10.90154416
74MAP3K70.90055297
75RET0.89765968
76PRKD30.89117426
77IRAK40.84709869
78GRK60.83680632
79PKN10.83371469
80ERBB30.82761240
81CCNB10.82738004
82MST1R0.82451763
83MAP3K110.82112738
84CSNK1G20.81576967
85NTRK10.81105407
86TESK10.80882604
87AKT30.80671690
88MAP3K120.80162206
89GRK50.79443046
90PLK20.78785433
91MTOR0.78525840
92MAPK150.78061480
93CDK70.77504135
94ACVR1B0.77257717
95EPHA40.76252391
96VRK10.76063636
97ALK0.75503851
98KSR10.74862914
99ARAF0.74725772
100IKBKE0.71024995
101SCYL20.70666485
102DMPK0.69034663
103EIF2AK30.68805848
104BMX0.68666445
105CDK60.67374086
106RAF10.67082711
107MAP2K10.66598574
108FGFR20.66421630
109TAOK20.66215887
110MAP2K40.64009829
111MARK20.62797237
112PAK20.62521746
113MAP3K10.62387364
114ITK0.62274320
115FLT30.61572173
116TNK20.59759244
117CAMK10.59182021
118MAP2K70.59066149
119MARK10.59013245
120ERN10.58528949
121CSNK1A1L0.57154542
122PRKCG0.56908899
123WNK10.56052972
124GRK70.55380375
125PRKD20.55352849
126PTK2B0.55264895
127PTK20.52995792
128PIK3CG0.52269015
129MAP3K50.51813697
130DAPK20.51636951
131PHKG20.51551349
132PHKG10.51551349
133EPHB20.51301211
134PRKCI0.51040892
135ABL20.50029215
136NEK20.49836987
137PDGFRB0.49589097
138PRKAA20.49554284
139EIF2AK20.49511153
140STK110.49359393
141CDK40.48478615
142CDK90.47661169
143PDK30.44537872
144PDK40.44537872
145TEC0.44521619
146GSK3A0.43806701
147PRKCQ0.43329685
148PRPF4B0.42238480
149DYRK20.42216056
150NTRK20.41538971
151CAMK2A0.41490414
152DYRK1B0.41489389
153DAPK10.40839061
154ABL10.40764870
155CHUK0.40711959
156MAP3K100.40699900
157EIF2AK10.40081622
158WNK30.39288854
159CDK30.38891724
160MET0.38750642
161PBK0.35711495
162CSNK1D0.34947430
163PLK30.34061694
164MAP3K40.33287058
165TGFBR10.33115624
166CSNK1G30.33103740
167PDPK10.32344597
168CSNK1A10.32335044
169PIM20.32215754
170PRKACA0.31566217
171PRKCA0.28967931
172CAMK2D0.26986928
173PNCK0.26538644
174SYK0.26341365

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047443.15952149
2alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.91116435
3Linoleic acid metabolism_Homo sapiens_hsa005912.80878229
4Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.70396979
5Fatty acid elongation_Homo sapiens_hsa000622.50430757
6Butanoate metabolism_Homo sapiens_hsa006502.25657540
7Dorso-ventral axis formation_Homo sapiens_hsa043202.22770299
8Axon guidance_Homo sapiens_hsa043602.21320389
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.19222818
10Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.01605763
11Tight junction_Homo sapiens_hsa045301.89002961
12ECM-receptor interaction_Homo sapiens_hsa045121.83087022
13Basal cell carcinoma_Homo sapiens_hsa052171.78424243
14Nitrogen metabolism_Homo sapiens_hsa009101.77280331
15Maturity onset diabetes of the young_Homo sapiens_hsa049501.76541219
16Hippo signaling pathway_Homo sapiens_hsa043901.73433750
17VEGF signaling pathway_Homo sapiens_hsa043701.71503780
18Fatty acid biosynthesis_Homo sapiens_hsa000611.71296408
19Protein export_Homo sapiens_hsa030601.69499545
20Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.68242586
21Bladder cancer_Homo sapiens_hsa052191.66903250
22Homologous recombination_Homo sapiens_hsa034401.59500079
23Ether lipid metabolism_Homo sapiens_hsa005651.59246301
24Caffeine metabolism_Homo sapiens_hsa002321.57485023
25Hedgehog signaling pathway_Homo sapiens_hsa043401.56361221
26Oxidative phosphorylation_Homo sapiens_hsa001901.47953949
27Vascular smooth muscle contraction_Homo sapiens_hsa042701.47715178
28Primary immunodeficiency_Homo sapiens_hsa053401.47239359
29Renal cell carcinoma_Homo sapiens_hsa052111.46786633
30Basal transcription factors_Homo sapiens_hsa030221.45994101
31Fat digestion and absorption_Homo sapiens_hsa049751.45639733
32Proteoglycans in cancer_Homo sapiens_hsa052051.41808732
33Vitamin digestion and absorption_Homo sapiens_hsa049771.41634334
34RNA polymerase_Homo sapiens_hsa030201.41629893
35Non-small cell lung cancer_Homo sapiens_hsa052231.40952382
36Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.40088674
37Glioma_Homo sapiens_hsa052141.39026326
38Tryptophan metabolism_Homo sapiens_hsa003801.35760836
39Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.34337375
40Amoebiasis_Homo sapiens_hsa051461.33460278
41Sphingolipid metabolism_Homo sapiens_hsa006001.30525127
42Intestinal immune network for IgA production_Homo sapiens_hsa046721.29360549
43Focal adhesion_Homo sapiens_hsa045101.29259580
44Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.29033932
45Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.28470094
46Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.27364294
47Steroid hormone biosynthesis_Homo sapiens_hsa001401.25903669
48Melanogenesis_Homo sapiens_hsa049161.23612439
49ABC transporters_Homo sapiens_hsa020101.21042469
50Long-term potentiation_Homo sapiens_hsa047201.19835486
51Retinol metabolism_Homo sapiens_hsa008301.19395391
52Collecting duct acid secretion_Homo sapiens_hsa049661.19086371
53Propanoate metabolism_Homo sapiens_hsa006401.18885888
54Circadian rhythm_Homo sapiens_hsa047101.18232624
55ErbB signaling pathway_Homo sapiens_hsa040121.17878076
56Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.17388871
57Fanconi anemia pathway_Homo sapiens_hsa034601.15742465
58Wnt signaling pathway_Homo sapiens_hsa043101.13614478
59Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.12579443
60Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.11977969
61Oocyte meiosis_Homo sapiens_hsa041141.10461038
62Nicotine addiction_Homo sapiens_hsa050331.09871763
63Adherens junction_Homo sapiens_hsa045201.09776822
64Chemical carcinogenesis_Homo sapiens_hsa052041.09005492
65Glycerophospholipid metabolism_Homo sapiens_hsa005641.06531834
66Primary bile acid biosynthesis_Homo sapiens_hsa001201.06217451
67Sphingolipid signaling pathway_Homo sapiens_hsa040711.05490480
68Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.03995950
69Endometrial cancer_Homo sapiens_hsa052131.02116105
70Proteasome_Homo sapiens_hsa030501.01235898
71Renin secretion_Homo sapiens_hsa049241.00419375
72Type I diabetes mellitus_Homo sapiens_hsa049401.00280474
73Ras signaling pathway_Homo sapiens_hsa040141.00175884
74GnRH signaling pathway_Homo sapiens_hsa049121.00096344
75Small cell lung cancer_Homo sapiens_hsa052220.99780557
76Leukocyte transendothelial migration_Homo sapiens_hsa046700.98710234
77Cyanoamino acid metabolism_Homo sapiens_hsa004600.97076282
78Thyroid cancer_Homo sapiens_hsa052160.96494233
79Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.95950547
80Estrogen signaling pathway_Homo sapiens_hsa049150.94552390
81NOD-like receptor signaling pathway_Homo sapiens_hsa046210.94333944
82TGF-beta signaling pathway_Homo sapiens_hsa043500.94269279
83SNARE interactions in vesicular transport_Homo sapiens_hsa041300.93950900
84Peroxisome_Homo sapiens_hsa041460.93810976
85Arachidonic acid metabolism_Homo sapiens_hsa005900.93243614
86MicroRNAs in cancer_Homo sapiens_hsa052060.91652459
87Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.91650398
88Oxytocin signaling pathway_Homo sapiens_hsa049210.91115990
89Phospholipase D signaling pathway_Homo sapiens_hsa040720.90250664
90Regulation of actin cytoskeleton_Homo sapiens_hsa048100.90246655
91beta-Alanine metabolism_Homo sapiens_hsa004100.88325584
92Serotonergic synapse_Homo sapiens_hsa047260.85835431
93Long-term depression_Homo sapiens_hsa047300.85658972
94Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.85560685
95Selenocompound metabolism_Homo sapiens_hsa004500.83966642
96RNA degradation_Homo sapiens_hsa030180.83796522
97Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.82535905
98Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.82512801
99Fatty acid metabolism_Homo sapiens_hsa012120.81274823
100Regulation of autophagy_Homo sapiens_hsa041400.81152344
101mTOR signaling pathway_Homo sapiens_hsa041500.81062396
102Asthma_Homo sapiens_hsa053100.80419031
103Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.80252372
104Parkinsons disease_Homo sapiens_hsa050120.80247598
105Mineral absorption_Homo sapiens_hsa049780.79930669
106Protein digestion and absorption_Homo sapiens_hsa049740.79293526
107Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.79005568
108Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.77939353
109Choline metabolism in cancer_Homo sapiens_hsa052310.75289299
110Salmonella infection_Homo sapiens_hsa051320.74609613
111Taste transduction_Homo sapiens_hsa047420.74424386
112Lysine degradation_Homo sapiens_hsa003100.74002110
113Endocytosis_Homo sapiens_hsa041440.73235239
114Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.72986142
115Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.72435212
116Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.72212963
117Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.72130638
118PPAR signaling pathway_Homo sapiens_hsa033200.70631951
119Autoimmune thyroid disease_Homo sapiens_hsa053200.70454079
120Insulin secretion_Homo sapiens_hsa049110.70218429
121Sulfur metabolism_Homo sapiens_hsa009200.68242998
122Amphetamine addiction_Homo sapiens_hsa050310.67984284
123Central carbon metabolism in cancer_Homo sapiens_hsa052300.67767089
124Rap1 signaling pathway_Homo sapiens_hsa040150.66211337
125Morphine addiction_Homo sapiens_hsa050320.65786902
126Phenylalanine metabolism_Homo sapiens_hsa003600.65413793
127Glycerolipid metabolism_Homo sapiens_hsa005610.65391675
128Gastric acid secretion_Homo sapiens_hsa049710.65352371
129Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.65339394
130Allograft rejection_Homo sapiens_hsa053300.64809813
131Steroid biosynthesis_Homo sapiens_hsa001000.64579300
132Ovarian steroidogenesis_Homo sapiens_hsa049130.64396841
133cGMP-PKG signaling pathway_Homo sapiens_hsa040220.63909043
134cAMP signaling pathway_Homo sapiens_hsa040240.63331682
135Prostate cancer_Homo sapiens_hsa052150.63067208
136Pathways in cancer_Homo sapiens_hsa052000.62002501
137Glutamatergic synapse_Homo sapiens_hsa047240.61871896
138Graft-versus-host disease_Homo sapiens_hsa053320.61812867
139Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.59999133
140Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.59986595
141Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.59928912
142Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.58648184
143Metabolic pathways_Homo sapiens_hsa011000.57951797
144Olfactory transduction_Homo sapiens_hsa047400.57916366
145Melanoma_Homo sapiens_hsa052180.57690197
146Rheumatoid arthritis_Homo sapiens_hsa053230.56744986
147Toxoplasmosis_Homo sapiens_hsa051450.56502309
148mRNA surveillance pathway_Homo sapiens_hsa030150.56356898
149Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.56135323
150Calcium signaling pathway_Homo sapiens_hsa040200.56100809
151Pancreatic cancer_Homo sapiens_hsa052120.56091629
152Adipocytokine signaling pathway_Homo sapiens_hsa049200.55743829
153Hematopoietic cell lineage_Homo sapiens_hsa046400.55623883
154Histidine metabolism_Homo sapiens_hsa003400.55541330
155Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.55534083
156Gap junction_Homo sapiens_hsa045400.55390849
157One carbon pool by folate_Homo sapiens_hsa006700.55237755
158Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.54840548
159T cell receptor signaling pathway_Homo sapiens_hsa046600.54220635
160Insulin resistance_Homo sapiens_hsa049310.53946001
161MAPK signaling pathway_Homo sapiens_hsa040100.53772312
162Thyroid hormone signaling pathway_Homo sapiens_hsa049190.52444517
163Circadian entrainment_Homo sapiens_hsa047130.52241687
164RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.51955630
165Purine metabolism_Homo sapiens_hsa002300.50741329
166p53 signaling pathway_Homo sapiens_hsa041150.49784236
167Salivary secretion_Homo sapiens_hsa049700.49776662
168Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.48890571
169Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.48703246
170Synaptic vesicle cycle_Homo sapiens_hsa047210.48058912
171Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.46934565
172Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.43408647
173Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.42994613
174Huntingtons disease_Homo sapiens_hsa050160.42479106
175Jak-STAT signaling pathway_Homo sapiens_hsa046300.38221140
176Pyrimidine metabolism_Homo sapiens_hsa002400.37273239
177GABAergic synapse_Homo sapiens_hsa047270.35839819
178Alzheimers disease_Homo sapiens_hsa050100.33990033

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