ACPP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an enzyme that catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. It is synthesized under androgen regulation and is secreted by the epithelial cells of the prostate gland. An alternatively spliced transcript variant encoding a longer isoform has been found for this gene. This isoform contains a transmembrane domain and is localized in the plasma membrane-endosomal-lysosomal pathway. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1iron ion import (GO:0097286)8.20126225
2artery development (GO:0060840)7.46948146
3biotin metabolic process (GO:0006768)7.44802064
4protein autoprocessing (GO:0016540)7.30494909
5prostate gland epithelium morphogenesis (GO:0060740)6.78405272
6positive regulation of macrophage cytokine production (GO:0060907)6.75373192
7prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060526.65085094
8regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)6.58158366
9opsonization (GO:0008228)6.39830934
10neurofilament cytoskeleton organization (GO:0060052)6.38421866
11epithelial cell maturation (GO:0002070)6.36800744
12regulation of receptor binding (GO:1900120)6.28547589
13positive regulation of steroid hormone secretion (GO:2000833)6.05892709
14import into cell (GO:0098657)5.87651405
15long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)5.85551478
16endothelial cell chemotaxis (GO:0035767)5.80802735
17peptidyl-tyrosine autophosphorylation (GO:0038083)5.59687204
18mitotic cell cycle arrest (GO:0071850)5.34309361
19intestinal epithelial cell development (GO:0060576)5.33324244
20adaptation of signaling pathway (GO:0023058)5.24646764
21fatty-acyl-CoA biosynthetic process (GO:0046949)5.16772375
22antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.15076344
23carnitine shuttle (GO:0006853)5.13983093
24neutrophil activation involved in immune response (GO:0002283)5.10493269
25positive regulation of transcription from RNA polymerase III promoter (GO:0045945)5.08219058
26positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)5.04582137
27pharyngeal system development (GO:0060037)4.84663284
28detection of temperature stimulus (GO:0016048)4.83653811
29response to peptidoglycan (GO:0032494)4.75186758
30response to testosterone (GO:0033574)4.61277036
31lung epithelial cell differentiation (GO:0060487)4.58929130
32positive regulation of cellular amine metabolic process (GO:0033240)4.56280724
33positive regulation of cellular amide metabolic process (GO:0034250)4.55761256
34regulation of macrophage cytokine production (GO:0010935)4.54444325
35thioester biosynthetic process (GO:0035384)4.49264111
36acyl-CoA biosynthetic process (GO:0071616)4.49264111
37positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610814.48866196
38granulocyte activation (GO:0036230)4.47943829
39acetyl-CoA metabolic process (GO:0006084)4.47334047
40hydrogen peroxide biosynthetic process (GO:0050665)4.45682993
41lung cell differentiation (GO:0060479)4.45384907
42epithelial cell differentiation involved in prostate gland development (GO:0060742)4.38198488
43neutrophil activation (GO:0042119)4.33497366
44negative regulation of homotypic cell-cell adhesion (GO:0034111)4.33029785
45respiratory burst (GO:0045730)4.28576252
46linoleic acid metabolic process (GO:0043651)4.27809074
47bundle of His cell to Purkinje myocyte communication (GO:0086069)4.27459347
48superoxide anion generation (GO:0042554)4.26963727
49carnitine transmembrane transport (GO:1902603)4.24266469
50regulation of protein polyubiquitination (GO:1902914)4.19897926
51regulation of viral entry into host cell (GO:0046596)4.19326286
52regulation of insulin-like growth factor receptor signaling pathway (GO:0043567)4.08369984
53fatty acid transmembrane transport (GO:1902001)4.04889879
54regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)4.03834831
55desmosome organization (GO:0002934)4.00384694
56long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.99748352
57very-low-density lipoprotein particle assembly (GO:0034379)3.90736577
58reactive oxygen species biosynthetic process (GO:1903409)3.89360152
59regulation of platelet aggregation (GO:0090330)3.86894355
60regulation of steroid hormone secretion (GO:2000831)3.86253941
61positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.84096012
62carnitine transport (GO:0015879)3.81559579
63amino-acid betaine transport (GO:0015838)3.81559579
64protein homotrimerization (GO:0070207)3.79371393
65toxin transport (GO:1901998)3.78356233
66cellular response to interferon-alpha (GO:0035457)3.73495786
67lung lobe morphogenesis (GO:0060463)3.67673052
68glucocorticoid receptor signaling pathway (GO:0042921)3.67095237
69immunoglobulin mediated immune response (GO:0016064)3.66867321
70modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.66197127
71positive regulation by organism of defense response of other organism involved in symbiotic interact3.66197127
72modulation by symbiont of host immune response (GO:0052553)3.66197127
73positive regulation by symbiont of host defense response (GO:0052509)3.66197127
74modulation by symbiont of host defense response (GO:0052031)3.66197127
75modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.66197127
76regulation of cell-cell adhesion mediated by cadherin (GO:2000047)3.65872795
77coenzyme A biosynthetic process (GO:0015937)3.64904048
78regulation of microtubule-based movement (GO:0060632)3.61765557
79fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.59192352
80positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.57535646
81lipopolysaccharide-mediated signaling pathway (GO:0031663)3.57319046
82positive regulation of heat generation (GO:0031652)3.56082135
83retinal metabolic process (GO:0042574)3.55058520
84regulation of fever generation (GO:0031620)3.54142175
85glandular epithelial cell differentiation (GO:0002067)3.52760507
86Golgi to endosome transport (GO:0006895)3.49797584
87leukocyte aggregation (GO:0070486)3.49297690
88production of molecular mediator involved in inflammatory response (GO:0002532)3.47761886
89positive regulation of monocyte chemotaxis (GO:0090026)3.41585115
90positive regulation of chemokine secretion (GO:0090197)3.41515413
91androgen receptor signaling pathway (GO:0030521)3.40877386
92hemidesmosome assembly (GO:0031581)3.40721337
93regulation of activation of Janus kinase activity (GO:0010533)3.39465342
94apical protein localization (GO:0045176)3.38348212
95quaternary ammonium group transport (GO:0015697)3.36748897
96phospholipid scrambling (GO:0017121)3.35370120
97positive regulation of chemokine biosynthetic process (GO:0045080)3.34853518
98regulation of monocyte chemotaxis (GO:0090025)3.34503762
99monocyte chemotaxis (GO:0002548)3.33832556
100myeloid leukocyte mediated immunity (GO:0002444)3.33048851
101regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.32054406
102fatty-acyl-CoA metabolic process (GO:0035337)3.30257629
103lung secretory cell differentiation (GO:0061140)3.29763469
104regulation of homotypic cell-cell adhesion (GO:0034110)3.29200269
105regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)3.27710119
106positive regulation of type 2 immune response (GO:0002830)3.24257488
107positive regulation of mast cell degranulation (GO:0043306)3.22556882
108positive regulation of mast cell activation involved in immune response (GO:0033008)3.22556882
109regulation of ARF protein signal transduction (GO:0032012)3.22271194
110coenzyme A metabolic process (GO:0015936)3.21372814
111establishment of skin barrier (GO:0061436)3.21131054
112regulation of chemokine biosynthetic process (GO:0045073)3.20491725
113COPII vesicle coating (GO:0048208)3.20378114
114negative regulation of DNA repair (GO:0045738)3.17882320
115mitochondrion degradation (GO:0000422)3.15799258
116regulation of chemokine secretion (GO:0090196)3.13396064
117regulation of hypersensitivity (GO:0002883)3.09930027
118type I interferon signaling pathway (GO:0060337)3.09904420
119cellular response to type I interferon (GO:0071357)3.09904420
120cellular response to nicotine (GO:0071316)3.08331999
121interferon-gamma-mediated signaling pathway (GO:0060333)3.07842404
122response to type I interferon (GO:0034340)3.07148815
123positive regulation of keratinocyte differentiation (GO:0045618)3.05577664
124macrophage activation involved in immune response (GO:0002281)3.03956142
125cytoskeletal anchoring at plasma membrane (GO:0007016)3.03008159
126copper ion transport (GO:0006825)3.00030744
127pantothenate metabolic process (GO:0015939)2.99055100
128regulation of actin nucleation (GO:0051125)2.98559747
129response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.97627330
130response to host immune response (GO:0052572)2.97627330
131corticosteroid receptor signaling pathway (GO:0031958)2.97065569
132Golgi transport vesicle coating (GO:0048200)2.96134185
133COPI coating of Golgi vesicle (GO:0048205)2.96134185
134natural killer cell mediated immunity (GO:0002228)2.94174913
135natural killer cell mediated cytotoxicity (GO:0042267)2.94174913
136glomerular visceral epithelial cell development (GO:0072015)2.93751662
137purine nucleoside bisphosphate biosynthetic process (GO:0034033)2.92471456
138ribonucleoside bisphosphate biosynthetic process (GO:0034030)2.92471456
139nucleoside bisphosphate biosynthetic process (GO:0033866)2.92471456
140leukocyte mediated cytotoxicity (GO:0001909)2.92249524
141positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.92143810
142negative regulation of dendrite morphogenesis (GO:0050774)2.91873824
143regulation of heterotypic cell-cell adhesion (GO:0034114)2.91767525
144positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.91364934
145regulation of fatty acid beta-oxidation (GO:0031998)2.90865146
146detection of other organism (GO:0098543)2.90663139
147regulation of water loss via skin (GO:0033561)2.89797822
148positive regulation of natural killer cell differentiation (GO:0032825)2.88708192
149establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.87504413
150detection of bacterium (GO:0016045)2.86876317
151negative regulation of stress fiber assembly (GO:0051497)2.85716288
152dorsal/ventral neural tube patterning (GO:0021904)2.85679183
153positive regulation of response to extracellular stimulus (GO:0032106)2.84974473
154positive regulation of response to nutrient levels (GO:0032109)2.84974473
155positive regulation of interferon-alpha production (GO:0032727)2.83989847
156piRNA metabolic process (GO:0034587)2.82578288
157regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.82345953
158fructose metabolic process (GO:0006000)2.81858171
159axon development (GO:0061564)2.79479169
160positive regulation of alpha-beta T cell proliferation (GO:0046641)2.79063037
161positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.78758416
162regulation of RIG-I signaling pathway (GO:0039535)2.77553084
163myelin maintenance (GO:0043217)2.76410554
164neuronal action potential (GO:0019228)2.76148633
165peripheral nervous system neuron development (GO:0048935)2.76147416
166insulin-like growth factor receptor signaling pathway (GO:0048009)2.76015998
167positive regulation of mast cell activation (GO:0033005)2.75848630
168negative regulation of fatty acid transport (GO:2000192)2.75799536
169behavioral response to pain (GO:0048266)2.75610435
170myeloid cell activation involved in immune response (GO:0002275)2.73483628
171regulation of platelet activation (GO:0010543)2.73186930
172T-helper 1 type immune response (GO:0042088)2.73121155
173positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.73052575
174purinergic nucleotide receptor signaling pathway (GO:0035590)2.68258057
175regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.67442702
176regulation of heat generation (GO:0031650)2.67342756
177regulation of interferon-alpha production (GO:0032647)2.66389636
178positive regulation of cAMP-mediated signaling (GO:0043950)2.64764233
179molting cycle (GO:0042303)2.64737878
180hair cycle (GO:0042633)2.64737878
181regulation of vitamin D biosynthetic process (GO:0060556)2.63901667
182intermediate filament organization (GO:0045109)2.63892589
183response to interferon-alpha (GO:0035455)2.63541658
184neutrophil mediated immunity (GO:0002446)2.63416444
185positive regulation of acute inflammatory response (GO:0002675)2.62746387
186regulation of histone phosphorylation (GO:0033127)2.60590548
187negative regulation of myeloid cell apoptotic process (GO:0033033)2.60514218
188response to ATP (GO:0033198)2.58667049
189eosinophil chemotaxis (GO:0048245)2.56148158
190lymphocyte mediated immunity (GO:0002449)2.55053138
191superoxide metabolic process (GO:0006801)2.54787850
192positive regulation of interleukin-6 production (GO:0032755)2.54714768
193phagosome maturation (GO:0090382)2.53427412
194response to muramyl dipeptide (GO:0032495)2.52912803
195B cell mediated immunity (GO:0019724)2.51736236
196cellular response to zinc ion (GO:0071294)2.51346696
197positive regulation of nitric oxide biosynthetic process (GO:0045429)2.51150688
198positive regulation of interleukin-17 production (GO:0032740)2.51109368
199branching involved in prostate gland morphogenesis (GO:0060442)10.7967942

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse6.58356316
2BP1_19119308_ChIP-ChIP_Hs578T_Human6.54396805
3TP63_17297297_ChIP-ChIP_HaCaT_Human6.17767171
4AR_21909140_ChIP-Seq_LNCAP_Human5.78975051
5* PIAS1_25552417_ChIP-Seq_VCAP_Human5.62656598
6IRF8_21731497_ChIP-ChIP_J774_Mouse4.57306471
7IRF8_22096565_ChIP-ChIP_GC-B_Human4.48168848
8AR_21915096_ChIP-Seq_LNCaP-1F5_Human4.31804608
9* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human3.80039620
10IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.58814460
11* FOXA1_25552417_ChIP-Seq_VCAP_Human3.14774679
12FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.99512816
13Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.74556519
14* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.66585682
15TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.64120460
16* IRF8_27001747_Chip-Seq_BMDM_Mouse2.62543556
17AR_21572438_ChIP-Seq_LNCaP_Human2.58525182
18CHD1_26751641_Chip-Seq_LNCaP_Human2.55205514
19* TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.54512519
20IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.43322369
21RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.42738328
22NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.40537535
23SMAD_19615063_ChIP-ChIP_OVARY_Human2.37432471
24SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.24647074
25STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.15869681
26NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.14896506
27ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.13889098
28FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.97894819
29EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.96057551
30IGF1R_20145208_ChIP-Seq_DFB_Human1.92438513
31NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.85203337
32RACK7_27058665_Chip-Seq_MCF-7_Human1.85148306
33CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.84686686
34CDX2_19796622_ChIP-Seq_MESCs_Mouse1.84281021
35CREB1_26743006_Chip-Seq_LNCaP_Human1.82408468
36SOX2_27498859_Chip-Seq_STOMACH_Mouse1.78016842
37SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.76873043
38* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.76497742
39MYB_21317192_ChIP-Seq_ERMYB_Mouse1.69542431
40TCF7_22412390_ChIP-Seq_EML_Mouse1.64828372
41MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.64685840
42VDR_22108803_ChIP-Seq_LS180_Human1.63047878
43DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.60281647
44STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.59982180
45ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.59436409
46TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.57627659
47ESR2_21235772_ChIP-Seq_MCF-7_Human1.55622981
48SOX2_20726797_ChIP-Seq_SW620_Human1.54751223
49KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.54135996
50KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.54135996
51KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.54135996
52GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.53450376
53P63_26484246_Chip-Seq_KERATINOCYTES_Human1.51612521
54EZH2_22144423_ChIP-Seq_EOC_Human1.51492010
55LXR_22158963_ChIP-Seq_LIVER_Mouse1.50474992
56EGR1_19032775_ChIP-ChIP_M12_Human1.49353506
57MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.47818765
58STAT4_19710469_ChIP-ChIP_TH1__Mouse1.47626631
59ZNF263_19887448_ChIP-Seq_K562_Human1.44684948
60PKCTHETA_26484144_Chip-Seq_BREAST_Human1.44546703
61ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.40609933
62CJUN_26792858_Chip-Seq_BT549_Human1.40235412
63RUNX1_27514584_Chip-Seq_MCF-7_Human1.37909579
64FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.37906670
65STAT6_21828071_ChIP-Seq_BEAS2B_Human1.37272056
66ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.37179605
67DROSHA_22980978_ChIP-Seq_HELA_Human1.36711789
68* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.36505206
69HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.35198422
70ESR1_21235772_ChIP-Seq_MCF-7_Human1.32194931
71ERG_20517297_ChIP-Seq_VCAP_Human1.31338474
72CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.28727591
73* GATA3_24758297_ChIP-Seq_MCF-7_Human1.26385535
74CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.25834964
75FOXA2_19822575_ChIP-Seq_HepG2_Human1.24292868
76NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.23493917
77NRF2_20460467_ChIP-Seq_MEFs_Mouse1.23493917
78PPARA_22158963_ChIP-Seq_LIVER_Mouse1.21885822
79OCT1_27270436_Chip-Seq_PROSTATE_Human1.21876044
80VDR_24763502_ChIP-Seq_THP-1_Human1.20863176
81CLOCK_20551151_ChIP-Seq_293T_Human1.19135220
82PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.18849421
83TP53_18474530_ChIP-ChIP_U2OS_Human1.18261418
84* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.17896296
85* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.16134532
86* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.16134532
87LXR_22292898_ChIP-Seq_THP-1_Human1.15280873
88ERG_21242973_ChIP-ChIP_JURKAT_Human1.14971816
89RUNX_20019798_ChIP-Seq_JUKART_Human1.11720606
90HIF1A_21447827_ChIP-Seq_MCF-7_Human1.11664905
91CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10556717
92* VDR_24787735_ChIP-Seq_THP-1_Human1.10432373
93VDR_21846776_ChIP-Seq_THP-1_Human1.09120531
94FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.08418227
95ESR1_20079471_ChIP-ChIP_T-47D_Human1.06933486
96BMI1_23680149_ChIP-Seq_NPCS_Mouse1.06569051
97WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.06143219
98ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.06047311
99GATA1_19941826_ChIP-Seq_K562_Human1.05201460
100CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.04571278
101KDM5A_27292631_Chip-Seq_BREAST_Human1.04318988
102TP63_23658742_ChIP-Seq_EP156T_Human1.04102296
103SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.03863607
104SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.03324600
105IKZF1_21737484_ChIP-ChIP_HCT116_Human1.02500060
106BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.02467802
107NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.01877426
108PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01551665
109* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.01532342
110GATA6_25053715_ChIP-Seq_YYC3_Human1.01272448
111CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99497114
112GATA2_21666600_ChIP-Seq_HMVEC_Human0.97838586
113STAT1_20625510_ChIP-Seq_HELA_Human0.97725589
114KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.97317242
115KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.96914262
116* ZNF217_24962896_ChIP-Seq_MCF-7_Human0.96862834
117TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.96443314
118SMC4_20622854_ChIP-Seq_HELA_Human0.94729044
119DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.93441284
120THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.92533962
121AHR_22903824_ChIP-Seq_MCF-7_Human0.92274763
122JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90879642
123* AR_25329375_ChIP-Seq_VCAP_Human0.90681976
124JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90599884
125ELF5_23300383_ChIP-Seq_T47D_Human0.90149598
126HTT_18923047_ChIP-ChIP_STHdh_Human0.89636964
127RXR_22158963_ChIP-Seq_LIVER_Mouse0.89241579
128ZFP57_27257070_Chip-Seq_ESCs_Mouse0.88999035
129CDX2_20551321_ChIP-Seq_CACO-2_Human0.88915529
130PU_27001747_Chip-Seq_BMDM_Mouse0.88887841
131TCF4_18268006_ChIP-ChIP_LS174T_Human0.88665127
132CTNNB1_20460455_ChIP-Seq_HCT116_Human0.86194127
133VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.84873003
134LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.84398230
135CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.84298105
136KDM2B_26808549_Chip-Seq_K562_Human0.83431417
137SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.83191318
138JARID2_20075857_ChIP-Seq_MESCs_Mouse0.83125264
139EED_16625203_ChIP-ChIP_MESCs_Mouse0.82727499
140ELK3_25401928_ChIP-Seq_HUVEC_Human0.82413664
141RARG_19884340_ChIP-ChIP_MEFs_Mouse0.82039399
142SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.81391090
143* GATA4_25053715_ChIP-Seq_YYC3_Human0.80371532
144TET1_21490601_ChIP-Seq_MESCs_Mouse0.80189959
145AR_20517297_ChIP-Seq_VCAP_Human0.80076566
146EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.78722981
147PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.78714117
148CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.78710800
149ARNT_22903824_ChIP-Seq_MCF-7_Human0.78668459
150TRIM28_21343339_ChIP-Seq_HEK293_Human0.78209231
151ISL1_27105846_Chip-Seq_CPCs_Mouse0.78019330
152GATA1_22025678_ChIP-Seq_K562_Human0.77837264
153* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.77394845
154KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.76755959
155CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.76601682
156YAP1_20516196_ChIP-Seq_MESCs_Mouse0.76432496
157SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.75758562
158PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.75120416
159TBX20_22328084_ChIP-Seq_HEART_Mouse0.75028888
160KLF5_25053715_ChIP-Seq_YYC3_Human0.74942450
161SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.73679829
162CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.73579599
163TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.73394323
164SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.72832616
165MTF2_20144788_ChIP-Seq_MESCs_Mouse0.72459662
166FOXO3_23340844_ChIP-Seq_DLD1_Human0.72296183
167TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.72005589
168PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.71658986
169CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.71632017
170RXR_22108803_ChIP-Seq_LS180_Human0.71328904
171SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.71097365
172GATA3_21867929_ChIP-Seq_TH1_Mouse0.68835560
173KDM2B_26808549_Chip-Seq_REH_Human0.68099027
174NANOG_18555785_Chip-Seq_ESCs_Mouse0.67973036
175P300_19829295_ChIP-Seq_ESCs_Human0.67734138
176* SMAD4_21799915_ChIP-Seq_A2780_Human0.66874352
177TCF4_22108803_ChIP-Seq_LS180_Human0.66515579
178JARID2_20064375_ChIP-Seq_MESCs_Mouse0.66340076
179CMYC_18555785_Chip-Seq_ESCs_Mouse0.66120552
180* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.65675283
181BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.65459853
182KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.65387588
183NMYC_18555785_Chip-Seq_ESCs_Mouse0.65049723

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002009_preneoplasia5.54361202
2MP0000537_abnormal_urethra_morphology4.63896051
3MP0005645_abnormal_hypothalamus_physiol4.07192421
4MP0004145_abnormal_muscle_electrophysio3.93115525
5MP0002735_abnormal_chemical_nociception3.84761603
6MP0001968_abnormal_touch/_nociception3.75797307
7MP0002736_abnormal_nociception_after3.63408994
8MP0002822_catalepsy3.62816573
9MP0003011_delayed_dark_adaptation3.55280727
10MP0009785_altered_susceptibility_to3.40006403
11MP0002148_abnormal_hypersensitivity_rea3.36437608
12MP0001835_abnormal_antigen_presentation3.32880600
13MP0003315_abnormal_perineum_morphology3.32455075
14MP0003436_decreased_susceptibility_to3.21392076
15MP0003724_increased_susceptibility_to3.19832515
16MP0008961_abnormal_basal_metabolism2.93989093
17MP0005647_abnormal_sex_gland2.74819875
18MP0002234_abnormal_pharynx_morphology2.72532340
19MP0001986_abnormal_taste_sensitivity2.72079603
20MP0005000_abnormal_immune_tolerance2.67158084
21MP0004947_skin_inflammation2.55209829
22MP0002419_abnormal_innate_immunity2.50836038
23MP0001873_stomach_inflammation2.50000001
24MP0005025_abnormal_response_to2.39552629
25MP0000579_abnormal_nail_morphology2.38874997
26MP0004185_abnormal_adipocyte_glucose2.37812694
27MP0006082_CNS_inflammation2.32187325
28MP0002796_impaired_skin_barrier2.17729045
29MP0002254_reproductive_system_inflammat2.13124742
30MP0004858_abnormal_nervous_system2.10878060
31MP0005367_renal/urinary_system_phenotyp2.07533242
32MP0000516_abnormal_urinary_system2.07533242
33MP0009764_decreased_sensitivity_to2.02468104
34MP0005671_abnormal_response_to1.96267874
35MP0005387_immune_system_phenotype1.95620902
36MP0001790_abnormal_immune_system1.95620902
37MP0002733_abnormal_thermal_nociception1.93474206
38MP0003303_peritoneal_inflammation1.93333360
39MP0008260_abnormal_autophagy1.87060630
40MP0000383_abnormal_hair_follicle1.86184287
41MP0002723_abnormal_immune_serum1.81166059
42MP0002452_abnormal_antigen_presenting1.79970419
43MP0005076_abnormal_cell_differentiation1.76222446
44MP0001800_abnormal_humoral_immune1.74367613
45MP0004381_abnormal_hair_follicle1.74131282
46MP0003453_abnormal_keratinocyte_physiol1.73756536
47MP0004036_abnormal_muscle_relaxation1.71919499
48MP0002277_abnormal_respiratory_mucosa1.70059111
49MP0001346_abnormal_lacrimal_gland1.69857126
50MP0001533_abnormal_skeleton_physiology1.69701479
51MP0000685_abnormal_immune_system1.68712064
52MP0005670_abnormal_white_adipose1.68040025
53MP0002909_abnormal_adrenal_gland1.67180644
54MP0010771_integument_phenotype1.66881157
55MP0000613_abnormal_salivary_gland1.65704982
56MP0003283_abnormal_digestive_organ1.65523756
57MP0002006_tumorigenesis1.60970290
58MP0010234_abnormal_vibrissa_follicle1.60640702
59MP0003075_altered_response_to1.58300088
60MP0005666_abnormal_adipose_tissue1.56509878
61MP0005464_abnormal_platelet_physiology1.55799950
62MP0001845_abnormal_inflammatory_respons1.54285476
63MP0001216_abnormal_epidermal_layer1.54040101
64MP0005451_abnormal_body_composition1.50752994
65MP0000858_altered_metastatic_potential1.49053064
66MP0001819_abnormal_immune_cell1.48550999
67MP0010678_abnormal_skin_adnexa1.48183106
68MP0001970_abnormal_pain_threshold1.46208793
69MP0001664_abnormal_digestion1.46193048
70MP0005220_abnormal_exocrine_pancreas1.44871318
71MP0001756_abnormal_urination1.44866642
72MP0002098_abnormal_vibrissa_morphology1.44440102
73MP0003941_abnormal_skin_development1.44407381
74MP0002420_abnormal_adaptive_immunity1.43892179
75MP0004510_myositis1.43665211
76MP0004782_abnormal_surfactant_physiolog1.42658427
77MP0000427_abnormal_hair_cycle1.38557635
78MP0005275_abnormal_skin_tensile1.35416426
79MP0009278_abnormal_bone_marrow1.35185733
80MP0002734_abnormal_mechanical_nocicepti1.29403510
81MP0002998_abnormal_bone_remodeling1.28812243
82MP0010155_abnormal_intestine_physiology1.27388114
83MP0004043_abnormal_pH_regulation1.25988124
84MP0002060_abnormal_skin_morphology1.25235350
85MP0002405_respiratory_system_inflammati1.24959429
86MP0001853_heart_inflammation1.22876244
87MP0005166_decreased_susceptibility_to1.22326209
88MP0001765_abnormal_ion_homeostasis1.21025699
89MP0000647_abnormal_sebaceous_gland1.20982848
90MP0003195_calcinosis1.20444332
91MP0003448_altered_tumor_morphology1.19892049
92MP0003879_abnormal_hair_cell1.18132845
93MP0001919_abnormal_reproductive_system1.13644336
94MP0008469_abnormal_protein_level1.13079803
95MP0000343_altered_response_to1.12581683
96MP0001851_eye_inflammation1.12466348
97MP0003566_abnormal_cell_adhesion1.12340172
98MP0000538_abnormal_urinary_bladder1.12203416
99MP0002693_abnormal_pancreas_physiology1.10951500
100MP0003183_abnormal_peptide_metabolism1.10695617
101MP0005501_abnormal_skin_physiology1.07311600
102MP0000462_abnormal_digestive_system1.06344471
103MP0001764_abnormal_homeostasis1.05703225
104MP0005167_abnormal_blood-brain_barrier1.05552146
105MP0005310_abnormal_salivary_gland1.04670272
106MP0000372_irregular_coat_pigmentation1.03102318
107MP0005187_abnormal_penis_morphology1.01960432
108MP0000534_abnormal_ureter_morphology0.99823166
109MP0000377_abnormal_hair_follicle0.98664835
110MP0000604_amyloidosis0.97182072
111MP0003705_abnormal_hypodermis_morpholog0.96621940
112MP0003186_abnormal_redox_activity0.95826049
113MP0010386_abnormal_urinary_bladder0.94027751
114MP0005390_skeleton_phenotype0.93542595
115MP0001191_abnormal_skin_condition0.92624314
116MP0001501_abnormal_sleep_pattern0.91235108
117MP0005164_abnormal_response_to0.89511671
118MP0000230_abnormal_systemic_arterial0.89479655
119MP0006276_abnormal_autonomic_nervous0.88566081
120MP0005058_abnormal_lysosome_morphology0.88109610
121MP0002108_abnormal_muscle_morphology0.86872406
122MP0000716_abnormal_immune_system0.83800328
123MP0005646_abnormal_pituitary_gland0.82661230
124MP0002090_abnormal_vision0.81050723
125MP0005397_hematopoietic_system_phenotyp0.80737160
126MP0001545_abnormal_hematopoietic_system0.80737160
127MP0005448_abnormal_energy_balance0.79829068
128MP0005375_adipose_tissue_phenotype0.79377937
129MP0003045_fibrosis0.78145164
130MP0002078_abnormal_glucose_homeostasis0.76609388
131MP0009333_abnormal_splenocyte_physiolog0.75029028
132MP0004264_abnormal_extraembryonic_tissu0.74102361
133MP0003656_abnormal_erythrocyte_physiolo0.73199081
134MP0004233_abnormal_muscle_weight0.72645047
135MP0002136_abnormal_kidney_physiology0.72477664
136MP0000367_abnormal_coat/_hair0.72427718
137MP0003136_yellow_coat_color0.70587900
138MP0009931_abnormal_skin_appearance0.70314297
139MP0001944_abnormal_pancreas_morphology0.70232165
140MP0000627_abnormal_mammary_gland0.69798866
141MP0005085_abnormal_gallbladder_physiolo0.68468648
142MP0002332_abnormal_exercise_endurance0.68073532
143MP0008004_abnormal_stomach_pH0.66723680
144MP0002166_altered_tumor_susceptibility0.65875005
145MP0003633_abnormal_nervous_system0.65460207
146MP0002557_abnormal_social/conspecific_i0.65302666
147MP0002163_abnormal_gland_morphology0.64413180
148MP0002653_abnormal_ependyma_morphology0.63847169
149MP0002876_abnormal_thyroid_physiology0.63248341
150MP0000678_abnormal_parathyroid_gland0.62713712
151MP0003866_abnormal_defecation0.61714175
152MP0003172_abnormal_lysosome_physiology0.61147937
153MP0003953_abnormal_hormone_level0.61004626
154MP0002398_abnormal_bone_marrow0.59682289
155MP0005636_abnormal_mineral_homeostasis0.59259901
156MP0005381_digestive/alimentary_phenotyp0.57855785
157MP0000631_abnormal_neuroendocrine_gland0.56522235
158MP0005319_abnormal_enzyme/_coenzyme0.56274456
159MP0000955_abnormal_spinal_cord0.55970176
160MP0003942_abnormal_urinary_system0.52915572
161MP0002089_abnormal_postnatal_growth/wei0.49589340
162MP0000432_abnormal_head_morphology0.48832943
163MP0000477_abnormal_intestine_morphology0.48397798
164MP0002115_abnormal_skeleton_extremities0.48357193
165MP0003868_abnormal_feces_composition0.46886461
166MP0002118_abnormal_lipid_homeostasis0.46490262
167MP0001348_abnormal_lacrimal_gland0.46016062
168MP0000920_abnormal_myelination0.45643609
169MP0000733_abnormal_muscle_development0.45318954
170MP0002111_abnormal_tail_morphology0.43378329
171MP0003631_nervous_system_phenotype0.41566543
172MP0000470_abnormal_stomach_morphology0.39667893
173MP0003936_abnormal_reproductive_system0.39595773
174MP0005623_abnormal_meninges_morphology0.38571427
175MP0000747_muscle_weakness0.37912730
176MP0001731_abnormal_postnatal_growth0.37494295
177MP0002088_abnormal_embryonic_growth/wei0.36181419
178MP0003984_embryonic_growth_retardation0.34570941
179MP0001145_abnormal_male_reproductive0.32534304
180MP0001661_extended_life_span0.32530016

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)7.18339023
2Recurrent abscess formation (HP:0002722)5.87798047
3Recurrent bacterial skin infections (HP:0005406)5.44746953
4Abnormality of secondary sexual hair (HP:0009888)5.40430713
5Abnormality of the axillary hair (HP:0100134)5.40430713
6Abnormality of the 1st metacarpal (HP:0010009)5.39951131
7Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)5.34897392
8Short 1st metacarpal (HP:0010034)5.34897392
9Flat acetabular roof (HP:0003180)5.22951160
10Testicular atrophy (HP:0000029)5.20244712
11Abnormal tarsal ossification (HP:0008369)5.16991006
12Recurrent gram-negative bacterial infections (HP:0005420)4.96649553
13Mediastinal lymphadenopathy (HP:0100721)4.78382942
14Thick nail (HP:0001805)4.73237201
15Aortic aneurysm (HP:0004942)4.65198066
16Abnormality of the distal phalanx of the thumb (HP:0009617)4.62600462
17Ulnar claw (HP:0001178)4.60251548
18Broad face (HP:0000283)4.57262532
19Amelogenesis imperfecta (HP:0000705)4.55432794
20Gonadotropin excess (HP:0000837)4.32305464
21Short phalanx of the thumb (HP:0009660)4.30168785
22Neoplasm of the heart (HP:0100544)4.22877265
23Abnormality of the phalanges of the hallux (HP:0010057)4.22007491
24Calf muscle hypertrophy (HP:0008981)4.17950547
25Abnormality of carpal bone ossification (HP:0006257)4.13975254
26Abnormal foot bone ossification (HP:0010675)4.08107746
27Gingivitis (HP:0000230)4.03977447
28Abnormality of macrophages (HP:0004311)3.96735952
29Abnormality of the proximal phalanges of the hand (HP:0009834)3.96517325
30Parakeratosis (HP:0001036)3.90242109
31Segmental peripheral demyelination/remyelination (HP:0003481)3.87851141
32Stomatitis (HP:0010280)3.83288070
33Septate vagina (HP:0001153)3.81804589
34Autoimmune thrombocytopenia (HP:0001973)3.76739031
35Plantar hyperkeratosis (HP:0007556)3.72109360
36Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.65529154
37Muscle hypertrophy of the lower extremities (HP:0008968)3.62449007
38Increased IgM level (HP:0003496)3.56743990
39Abnormal ossification of hand bones (HP:0005921)3.54963317
40Abnormal hand bone ossification (HP:0010660)3.53504303
41Obstructive lung disease (HP:0006536)3.51500539
42Chronic obstructive pulmonary disease (HP:0006510)3.51500539
43Abnormality of the distal phalanges of the toes (HP:0010182)3.51258704
44Malnutrition (HP:0004395)3.51159141
45Glomerulonephritis (HP:0000099)3.44418042
46Myokymia (HP:0002411)3.42222319
47Hypotrichosis (HP:0001006)3.41675351
48Increased IgE level (HP:0003212)3.38468530
49Prostate neoplasm (HP:0100787)3.37004848
50Flattened epiphyses (HP:0003071)3.34990138
51Palmoplantar hyperkeratosis (HP:0000972)3.32134505
52Sparse lateral eyebrow (HP:0005338)3.30031994
53Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)3.24931469
54Premature loss of primary teeth (HP:0006323)3.23510941
55Vasculitis (HP:0002633)3.23306559
56Lip pit (HP:0100267)3.20445295
57Recurrent skin infections (HP:0001581)3.19410578
58Palmar hyperkeratosis (HP:0010765)3.14336302
59Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.07073840
60Nephritis (HP:0000123)3.04497324
61Submucous cleft hard palate (HP:0000176)3.04204852
62Bronchomalacia (HP:0002780)3.02076316
63Elevated erythrocyte sedimentation rate (HP:0003565)2.99238665
64Fragile nails (HP:0001808)2.99023873
65Anal stenosis (HP:0002025)2.92414443
66Interstitial pulmonary disease (HP:0006530)2.92122473
67Periodontitis (HP:0000704)2.89316240
68Aortic dissection (HP:0002647)2.85597340
69Onycholysis (HP:0001806)2.85555436
70Axonal loss (HP:0003447)2.84932200
71Recurrent fungal infections (HP:0002841)2.81472885
72Abnormality of the parathyroid morphology (HP:0011766)2.79668647
73Partial duplication of thumb phalanx (HP:0009944)2.77088973
74Broad metatarsal (HP:0001783)2.75362539
75Hypergammaglobulinemia (HP:0010702)2.73674491
76Tetraparesis (HP:0002273)2.72105365
77Milia (HP:0001056)2.71260120
78Azoospermia (HP:0000027)2.71185900
79Optic neuritis (HP:0100653)2.70637400
80Retrobulbar optic neuritis (HP:0100654)2.70637400
81Bifid scrotum (HP:0000048)2.69153650
82Abnormality of the fingertips (HP:0001211)2.69013783
83Pustule (HP:0200039)2.67735193
84Orchitis (HP:0100796)2.63624594
85Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.62581850
86Urticaria (HP:0001025)2.62442010
87Fibular aplasia (HP:0002990)2.60029365
88Woolly hair (HP:0002224)2.51545816
89Congenital ichthyosiform erythroderma (HP:0007431)2.50521003
90Aplasia/hypoplasia of the femur (HP:0005613)2.47221733
91Xerostomia (HP:0000217)2.47038642
92Short nail (HP:0001799)2.46713140
93Nail dystrophy (HP:0008404)2.46700650
94Intrahepatic cholestasis (HP:0001406)2.44417667
95Testicular neoplasm (HP:0010788)2.42201557
96Abnormality of liposaccharide metabolism (HP:0010968)2.40750371
97Abnormality of glycosphingolipid metabolism (HP:0004343)2.40750371
98Abnormality of glycolipid metabolism (HP:0010969)2.40750371
99Microretrognathia (HP:0000308)2.40454159
100Aortic regurgitation (HP:0001659)2.39744400
101Dysautonomia (HP:0002459)2.38700932
10211 pairs of ribs (HP:0000878)2.35485330
103Gastrointestinal infarctions (HP:0005244)2.35358919
104Erythema (HP:0010783)2.34126067
105Abnormal hemoglobin (HP:0011902)2.32443060
106Myositis (HP:0100614)2.30683331
107Ureteral stenosis (HP:0000071)2.30524517
108Sepsis (HP:0100806)2.30446657
109Cervical subluxation (HP:0003308)2.29309415
110Partial duplication of the phalanx of hand (HP:0009999)2.28415557
111Autoimmune hemolytic anemia (HP:0001890)2.27694736
112Gangrene (HP:0100758)2.25999592
113Ureteral obstruction (HP:0006000)2.25737055
114Corneal erosion (HP:0200020)2.23314313
115Gaze-evoked nystagmus (HP:0000640)2.23111961
116Laryngomalacia (HP:0001601)2.21745452
117Abnormality of abdominal situs (HP:0011620)2.18769582
118Abdominal situs inversus (HP:0003363)2.18769582
119Basal ganglia calcification (HP:0002135)2.18544046
120Dysdiadochokinesis (HP:0002075)2.18086996
121Popliteal pterygium (HP:0009756)2.17943677
122Vacuolated lymphocytes (HP:0001922)2.16972625
123Anhidrosis (HP:0000970)2.16971204
124Osteomyelitis (HP:0002754)2.15724252
125Recurrent pneumonia (HP:0006532)2.13571523
126Congenital glaucoma (HP:0001087)2.12906339
127Bulbar palsy (HP:0001283)2.10603088
128Impaired smooth pursuit (HP:0007772)2.10581858
129Abnormality of nail color (HP:0100643)2.10316159
130Persistence of primary teeth (HP:0006335)2.09889534
131Cellulitis (HP:0100658)2.09675596
132Skin ulcer (HP:0200042)2.09086272
133Thoracolumbar scoliosis (HP:0002944)2.09077696
134Distal arthrogryposis (HP:0005684)2.08503233
135Systemic lupus erythematosus (HP:0002725)2.07459754
136Severe short stature (HP:0003510)2.06955432
137Tracheomalacia (HP:0002779)2.06743023
138Pruritus (HP:0000989)2.05822575
139Lower limb hyperreflexia (HP:0002395)2.05651554
140Aplasia cutis congenita (HP:0001057)2.04970509
141Hyperparathyroidism (HP:0000843)2.04821116
142Dysmetric saccades (HP:0000641)2.04411279
143Urethral obstruction (HP:0000796)2.01975739
144Pili torti (HP:0003777)2.01784223
145Erythroderma (HP:0001019)2.01350674
146Short humerus (HP:0005792)1.98721100
147Recurrent cutaneous fungal infections (HP:0011370)1.98299926
148Chronic mucocutaneous candidiasis (HP:0002728)1.98299926
149Alopecia of scalp (HP:0002293)1.96481505
150Intention tremor (HP:0002080)1.96274536
151Genetic anticipation (HP:0003743)1.93695396
152Pulmonary infiltrates (HP:0002113)1.93574365
153Gastrointestinal dysmotility (HP:0002579)1.92925968
154Germ cell neoplasia (HP:0100728)1.92279548
155Osteolytic defects of the hand bones (HP:0009699)1.91879201
156Osteolytic defects of the phalanges of the hand (HP:0009771)1.91879201
157Distal lower limb muscle weakness (HP:0009053)1.91866888
158Bone pain (HP:0002653)1.90274172
159Neonatal hypoglycemia (HP:0001998)1.89126357
160Hypothermia (HP:0002045)1.88805229
161Obstructive sleep apnea (HP:0002870)1.88801006
162Meningitis (HP:0001287)1.88678015
163Recurrent viral infections (HP:0004429)1.86921102
164Shallow orbits (HP:0000586)1.84109432
165Cheilitis (HP:0100825)1.84001747
166Abnormality of the prostate (HP:0008775)1.83869874
167Joint swelling (HP:0001386)1.83504687
168Advanced eruption of teeth (HP:0006288)1.83178555
169Hyperpituitarism (HP:0010514)1.82458092
170Abnormal spermatogenesis (HP:0008669)1.82302523
171Aplastic anemia (HP:0001915)1.81299690
172Abnormal blistering of the skin (HP:0008066)1.81220807
173Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.80677003
174Atrophic scars (HP:0001075)1.79971213
175Short femoral neck (HP:0100864)1.78792538
176Skin nodule (HP:0200036)1.78539459
177Absent phalangeal crease (HP:0006109)1.77429209
178Upper limb muscle weakness (HP:0003484)1.77295284
179Overgrowth (HP:0001548)1.77223566
180Abnormality of the nasal septum (HP:0000419)1.76383772
181Down-sloping shoulders (HP:0200021)1.75888248
182Abnormality of the calf musculature (HP:0001430)1.75482684
183Recurrent lower respiratory tract infections (HP:0002783)1.75171438
184Disinhibition (HP:0000734)1.74594310
185Chin dimple (HP:0010751)1.74108943
186Narrow palate (HP:0000189)1.74056603
187Growth hormone excess (HP:0000845)1.73854333
188Short metatarsal (HP:0010743)1.72399364
189Stroke (HP:0001297)1.70928305
190Right ventricular cardiomyopathy (HP:0011663)1.70875392
191Macroorchidism (HP:0000053)1.70365982
192Abnormality of the fibula (HP:0002991)1.69661513
193Absent hair (HP:0002298)1.68170421
194Hypoplastic nipples (HP:0002557)1.66886893
195Limb ataxia (HP:0002070)1.66399986

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CAMK1D8.37510855
2RIPK47.53997967
3CAMK1G6.47819312
4TAOK15.42671780
5AKT34.41641376
6PBK4.09895848
7MST1R3.92381874
8MAP3K143.69588887
9BLK3.15584460
10EEF2K2.86501558
11TRIB32.65810722
12MARK22.42479103
13PRKD22.39056702
14MYLK2.38161794
15TBK12.27026085
16MST42.19106430
17IRAK42.03322947
18IRAK32.02082400
19TYK21.94939519
20EPHA31.89090703
21JAK31.86828735
22YES11.80760222
23MARK31.79423124
24IKBKE1.76999413
25TXK1.75250157
26JAK11.69716667
27IKBKB1.67734329
28MATK1.59483725
29MAP3K21.51499077
30SIK31.50082181
31NTRK11.42356435
32PRKD31.38324147
33PIM21.37834569
34PAK21.36387135
35BMPR21.36215752
36MAP3K131.35534994
37TESK21.33972857
38TRPM71.31729468
39KSR21.30930988
40CDK121.30904054
41SGK4941.29229826
42SGK2231.29229826
43SMG11.28692643
44PRKCI1.27724693
45FGFR31.27437313
46BMPR1B1.20602142
47MET1.18886059
48CAMK11.15500878
49EPHB11.15369523
50FGFR41.09466032
51MTOR1.07555550
52ARAF1.02802255
53BMX1.00504582
54MAP3K121.00244491
55CDC42BPA1.00075845
56MAP3K90.99300939
57IRAK10.97467918
58PRKAA20.96779840
59IRAK20.96722057
60MAPKAPK30.91734916
61MAP3K10.91616492
62ADRBK20.89068469
63GRK50.88517463
64JAK20.87151780
65EPHB20.86423946
66NEK90.84998912
67ERBB30.84790079
68PKN20.84515870
69RET0.83493430
70SIK10.83206941
71CHUK0.80950261
72PRKAA10.80156288
73ACVR1B0.78850852
74SGK20.78143808
75RAF10.77883958
76SYK0.75521421
77LIMK10.74965402
78FER0.74952705
79LCK0.74925129
80PRKCD0.72525268
81RPS6KA20.71262760
82SGK30.70923984
83CSK0.70843050
84LYN0.70704078
85HCK0.69788926
86DAPK20.69405421
87DMPK0.69205108
88ZAP700.67096927
89PRKCE0.66895466
90STK390.65589319
91EIF2AK20.63477610
92GSK3A0.60324013
93ABL20.59823980
94LMTK20.59650409
95NLK0.59517710
96WNK10.59123155
97ERBB40.59021366
98ICK0.58159654
99MAP4K10.57692665
100MAPKAPK50.56673655
101MAP2K10.56449253
102BRAF0.53653842
103ADRBK10.51992910
104MAP3K110.51704856
105PIM10.50507348
106STK240.49858925
107PDPK10.49620755
108MAP2K20.49564574
109WNK40.47916569
110CAMKK20.47736859
111ABL10.47107825
112STK110.46840269
113BCR0.46128641
114MAP3K50.45809401
115MAP3K30.43684537
116TAOK30.43624211
117CAMKK10.43568694
118FGR0.43268494
119MAPKAPK20.43029514
120ERN10.42865423
121PRKCZ0.42021084
122BTK0.41998092
123LATS10.41967970
124FRK0.40834845
125KIT0.40070721
126PDK10.39999404
127SCYL20.39935448
128NME20.37845248
129TEC0.37023074
130PRKD10.36466160
131PIK3CG0.35627764
132TESK10.35380165
133PRKCQ0.34423024
134PDGFRB0.33760547
135IGF1R0.33558664
136SGK10.33130913
137RPS6KA40.32509142
138PRKG20.32330751
139STK40.31410657
140BRD40.27794129
141PAK30.27025347
142STK380.26853832
143ERBB20.25354518
144CAMK40.25276579
145FYN0.24099345
146GSK3B0.23137334
147LRRK20.22183574
148MAPK80.21821142
149TNK20.21755123
150MINK10.20764204
151MAPK100.18700748
152ILK0.17943161
153MAP3K70.16216171
154MAPK10.15322629
155AKT10.15246563
156DAPK30.14962650
157CDK70.13206806
158MAPK140.12257452
159DDR20.11992828
160TGFBR20.11115666
161STK38L0.10314347
162EPHA20.09877997
163HIPK20.09223017
164TTN0.08703581
165GRK70.08356456
166RPS6KA30.06897014
167CAMK2G0.04351592
168CDK10.04095572

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000618.95786269
2Graft-versus-host disease_Homo sapiens_hsa053323.82642825
3Prostate cancer_Homo sapiens_hsa052153.18703945
4Leishmaniasis_Homo sapiens_hsa051402.90124780
5Fatty acid metabolism_Homo sapiens_hsa012122.76775265
6Staphylococcus aureus infection_Homo sapiens_hsa051502.74644129
7Toll-like receptor signaling pathway_Homo sapiens_hsa046202.48601724
8NOD-like receptor signaling pathway_Homo sapiens_hsa046212.43120285
9Rheumatoid arthritis_Homo sapiens_hsa053232.39899854
10Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.37578486
11Allograft rejection_Homo sapiens_hsa053302.37375769
12Legionellosis_Homo sapiens_hsa051342.34486005
13Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.20946967
14Pertussis_Homo sapiens_hsa051332.20361848
15Salmonella infection_Homo sapiens_hsa051322.16583274
16NF-kappa B signaling pathway_Homo sapiens_hsa040642.02098151
17RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.98958257
18TNF signaling pathway_Homo sapiens_hsa046681.93652898
19Malaria_Homo sapiens_hsa051441.92445042
20Tuberculosis_Homo sapiens_hsa051521.88372700
21Asthma_Homo sapiens_hsa053101.88248814
22Vascular smooth muscle contraction_Homo sapiens_hsa042701.86693047
23African trypanosomiasis_Homo sapiens_hsa051431.85021183
24Type I diabetes mellitus_Homo sapiens_hsa049401.84486908
25Osteoclast differentiation_Homo sapiens_hsa043801.72518639
26Hematopoietic cell lineage_Homo sapiens_hsa046401.66047755
27Phagosome_Homo sapiens_hsa041451.66022114
28Measles_Homo sapiens_hsa051621.64833045
29Intestinal immune network for IgA production_Homo sapiens_hsa046721.61746067
30Influenza A_Homo sapiens_hsa051641.60632505
31Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.53882917
32Lysine degradation_Homo sapiens_hsa003101.50579331
33Transcriptional misregulation in cancer_Homo sapiens_hsa052021.42569716
34Toxoplasmosis_Homo sapiens_hsa051451.41590675
35Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.40390633
36Autoimmune thyroid disease_Homo sapiens_hsa053201.38391041
37Thyroid hormone synthesis_Homo sapiens_hsa049181.36484603
38AMPK signaling pathway_Homo sapiens_hsa041521.32987633
39Propanoate metabolism_Homo sapiens_hsa006401.32636625
40Aldosterone synthesis and secretion_Homo sapiens_hsa049251.31122630
41Primary bile acid biosynthesis_Homo sapiens_hsa001201.30473283
42Vitamin digestion and absorption_Homo sapiens_hsa049771.29409516
43Amoebiasis_Homo sapiens_hsa051461.26861637
44Notch signaling pathway_Homo sapiens_hsa043301.25524318
45Chemokine signaling pathway_Homo sapiens_hsa040621.23683460
46Renin secretion_Homo sapiens_hsa049241.22841747
47AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.20642440
48Glucagon signaling pathway_Homo sapiens_hsa049221.20204208
49Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.19964465
50Mineral absorption_Homo sapiens_hsa049781.19183486
51Longevity regulating pathway - mammal_Homo sapiens_hsa042111.18359680
52Lysosome_Homo sapiens_hsa041421.16334584
53Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.15779663
54Apoptosis_Homo sapiens_hsa042101.14488608
55Jak-STAT signaling pathway_Homo sapiens_hsa046301.11820788
56Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.10993399
57Fructose and mannose metabolism_Homo sapiens_hsa000511.09551306
58Arginine and proline metabolism_Homo sapiens_hsa003301.09492268
59Insulin signaling pathway_Homo sapiens_hsa049101.01244343
60Cholinergic synapse_Homo sapiens_hsa047251.00564460
61Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.00510619
62alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.99566660
63Estrogen signaling pathway_Homo sapiens_hsa049150.99204391
64Pentose and glucuronate interconversions_Homo sapiens_hsa000400.97717748
65Insulin resistance_Homo sapiens_hsa049310.96302520
66Long-term depression_Homo sapiens_hsa047300.96024155
67Pyruvate metabolism_Homo sapiens_hsa006200.95710527
68Herpes simplex infection_Homo sapiens_hsa051680.94119500
69Hepatitis C_Homo sapiens_hsa051600.94095872
70Steroid biosynthesis_Homo sapiens_hsa001000.93938732
71Insulin secretion_Homo sapiens_hsa049110.93678981
72Renin-angiotensin system_Homo sapiens_hsa046140.92710680
73Serotonergic synapse_Homo sapiens_hsa047260.91833248
74Shigellosis_Homo sapiens_hsa051310.91287270
75Tight junction_Homo sapiens_hsa045300.90230680
76Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.89923509
77beta-Alanine metabolism_Homo sapiens_hsa004100.88798486
78mTOR signaling pathway_Homo sapiens_hsa041500.88731553
79ABC transporters_Homo sapiens_hsa020100.88017268
80Ovarian steroidogenesis_Homo sapiens_hsa049130.87618372
81Salivary secretion_Homo sapiens_hsa049700.86825739
82Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.86706559
83Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.86670275
84Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.86648756
85Collecting duct acid secretion_Homo sapiens_hsa049660.85325209
86Prion diseases_Homo sapiens_hsa050200.83465698
87Sphingolipid metabolism_Homo sapiens_hsa006000.83288840
88Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.81474901
89cGMP-PKG signaling pathway_Homo sapiens_hsa040220.79783789
90Prolactin signaling pathway_Homo sapiens_hsa049170.79260627
91SNARE interactions in vesicular transport_Homo sapiens_hsa041300.77874516
92Dorso-ventral axis formation_Homo sapiens_hsa043200.77335784
93Adherens junction_Homo sapiens_hsa045200.76494275
94Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.75880344
95Peroxisome_Homo sapiens_hsa041460.75436712
96Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.75387909
97Viral myocarditis_Homo sapiens_hsa054160.74539863
98GnRH signaling pathway_Homo sapiens_hsa049120.73797994
99Fatty acid degradation_Homo sapiens_hsa000710.73718222
100Bile secretion_Homo sapiens_hsa049760.72533578
101Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.71626871
102cAMP signaling pathway_Homo sapiens_hsa040240.71608634
103Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.71295945
104Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.69834683
105Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.68932001
106Sphingolipid signaling pathway_Homo sapiens_hsa040710.68377055
107B cell receptor signaling pathway_Homo sapiens_hsa046620.66687052
108Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.66248998
109Dopaminergic synapse_Homo sapiens_hsa047280.65410890
110Thyroid hormone signaling pathway_Homo sapiens_hsa049190.62094843
111Neurotrophin signaling pathway_Homo sapiens_hsa047220.60632514
112Long-term potentiation_Homo sapiens_hsa047200.60319400
113Primary immunodeficiency_Homo sapiens_hsa053400.60121507
114Endometrial cancer_Homo sapiens_hsa052130.58584805
115Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.58396378
116Hepatitis B_Homo sapiens_hsa051610.57803027
117T cell receptor signaling pathway_Homo sapiens_hsa046600.57159473
118MicroRNAs in cancer_Homo sapiens_hsa052060.56887396
119Choline metabolism in cancer_Homo sapiens_hsa052310.56399691
120Oxytocin signaling pathway_Homo sapiens_hsa049210.54830064
121Complement and coagulation cascades_Homo sapiens_hsa046100.54152209
122Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.53755096
123Antigen processing and presentation_Homo sapiens_hsa046120.53517066
124Leukocyte transendothelial migration_Homo sapiens_hsa046700.51841765
125Ether lipid metabolism_Homo sapiens_hsa005650.49664834
126Regulation of autophagy_Homo sapiens_hsa041400.49077362
127Arachidonic acid metabolism_Homo sapiens_hsa005900.48091372
128Acute myeloid leukemia_Homo sapiens_hsa052210.48040426
129Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.47958563
130PPAR signaling pathway_Homo sapiens_hsa033200.45869397
131Carbohydrate digestion and absorption_Homo sapiens_hsa049730.44701379
132Glycosaminoglycan degradation_Homo sapiens_hsa005310.42795756
133Type II diabetes mellitus_Homo sapiens_hsa049300.42304267
134Gastric acid secretion_Homo sapiens_hsa049710.41420406
135Circadian rhythm_Homo sapiens_hsa047100.41121987
136Cocaine addiction_Homo sapiens_hsa050300.39559961
137Pathways in cancer_Homo sapiens_hsa052000.38463961
138Gap junction_Homo sapiens_hsa045400.38283182
139Melanogenesis_Homo sapiens_hsa049160.38166665
140Platelet activation_Homo sapiens_hsa046110.38029663
141Amphetamine addiction_Homo sapiens_hsa050310.36633437
142Phosphatidylinositol signaling system_Homo sapiens_hsa040700.36118842
143Synaptic vesicle cycle_Homo sapiens_hsa047210.36026909
144ErbB signaling pathway_Homo sapiens_hsa040120.35943740
145Melanoma_Homo sapiens_hsa052180.35832436
146Circadian entrainment_Homo sapiens_hsa047130.35384750
147VEGF signaling pathway_Homo sapiens_hsa043700.35011235
148Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.34389807
149Phenylalanine metabolism_Homo sapiens_hsa003600.33972650
150Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.32983785
151Other glycan degradation_Homo sapiens_hsa005110.32302653
152Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.31459913
153Arginine biosynthesis_Homo sapiens_hsa002200.29639203
154Calcium signaling pathway_Homo sapiens_hsa040200.29195650
155Inositol phosphate metabolism_Homo sapiens_hsa005620.28956225
156Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.28943991
157Proteoglycans in cancer_Homo sapiens_hsa052050.28767227
158Focal adhesion_Homo sapiens_hsa045100.28281223
159Glutamatergic synapse_Homo sapiens_hsa047240.28136091
160Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.27782168
161ECM-receptor interaction_Homo sapiens_hsa045120.26898796
162Linoleic acid metabolism_Homo sapiens_hsa005910.25564226
163Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.24624263
164Bladder cancer_Homo sapiens_hsa052190.24315490
165Adipocytokine signaling pathway_Homo sapiens_hsa049200.23976566
166Pancreatic cancer_Homo sapiens_hsa052120.23711889
167Vibrio cholerae infection_Homo sapiens_hsa051100.22575687
168N-Glycan biosynthesis_Homo sapiens_hsa005100.21800587
169Endocytosis_Homo sapiens_hsa041440.21770394
170Epstein-Barr virus infection_Homo sapiens_hsa051690.21301281
171Histidine metabolism_Homo sapiens_hsa003400.20857062
172Rap1 signaling pathway_Homo sapiens_hsa040150.20805489
173Pancreatic secretion_Homo sapiens_hsa049720.20377572
174FoxO signaling pathway_Homo sapiens_hsa040680.20031376

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