ACPT

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Acid phosphatases are enzymes capable of hydrolyzing orthophosphoric acid esters in an acid medium. This gene is up-regulated by androgens and is down-regulated by estrogens in the prostate cancer cell line. This gene exhibits a lower level of expression in testicular cancer tissues than in normal tissues. The protein encoded by this gene has structural similarity to prostatic and lysosomal acid phosphatases. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cell aging (GO:0090344)9.86727786
2cellular response to ATP (GO:0071318)9.83907181
3DNA strand renaturation (GO:0000733)9.60223729
4regulation of skeletal muscle contraction (GO:0014819)9.53151535
5GDP-mannose metabolic process (GO:0019673)8.80655292
6meiotic chromosome segregation (GO:0045132)8.39991222
7regulation of synapse structural plasticity (GO:0051823)7.76731950
8protein carboxylation (GO:0018214)7.63740600
9peptidyl-glutamic acid carboxylation (GO:0017187)7.63740600
10adenosine receptor signaling pathway (GO:0001973)7.61586820
11mitotic cell cycle arrest (GO:0071850)7.58856744
12lens fiber cell differentiation (GO:0070306)6.93042962
13G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)6.84575318
14purinergic nucleotide receptor signaling pathway (GO:0035590)6.65588078
15regulation of cytokine production involved in inflammatory response (GO:1900015)6.39572261
16rRNA methylation (GO:0031167)6.17956268
17transepithelial transport (GO:0070633)6.06766971
18viral transcription (GO:0019083)6.02775975
19ribosomal small subunit biogenesis (GO:0042274)6.00642645
20negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)5.79471834
21translational termination (GO:0006415)5.77765117
22detection of light stimulus involved in sensory perception (GO:0050962)5.77058861
23detection of light stimulus involved in visual perception (GO:0050908)5.77058861
24rRNA modification (GO:0000154)5.43847141
25purine ribonucleotide transport (GO:0015868)5.27224677
26response to ATP (GO:0033198)5.23263789
27positive regulation of protein kinase C signaling (GO:0090037)5.21227281
28adenine nucleotide transport (GO:0051503)5.17762185
29estrogen biosynthetic process (GO:0006703)5.16424007
30short-term memory (GO:0007614)5.09267201
31sensory perception of taste (GO:0050909)5.03970306
32cotranslational protein targeting to membrane (GO:0006613)5.00374048
33SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.98243713
34protein targeting to ER (GO:0045047)4.95366647
35axon ensheathment in central nervous system (GO:0032291)4.92766508
36central nervous system myelination (GO:0022010)4.92766508
37nucleotide-sugar biosynthetic process (GO:0009226)4.87237922
38positive regulation of heat generation (GO:0031652)4.84493747
39presynaptic membrane assembly (GO:0097105)4.81198361
40purinergic receptor signaling pathway (GO:0035587)4.74878771
41establishment of protein localization to endoplasmic reticulum (GO:0072599)4.72336747
42behavioral response to nicotine (GO:0035095)4.70331653
43protein localization to endoplasmic reticulum (GO:0070972)4.61643130
44ribosomal large subunit biogenesis (GO:0042273)4.61130403
45granulocyte differentiation (GO:0030851)4.60153574
46cellular protein complex disassembly (GO:0043624)4.59286928
47neuron cell-cell adhesion (GO:0007158)4.57122927
48nucleoside transmembrane transport (GO:1901642)4.46148135
49regulation of phospholipid biosynthetic process (GO:0071071)4.45781797
50regulation of cell aging (GO:0090342)4.43669759
51translational elongation (GO:0006414)4.42612145
52viral life cycle (GO:0019058)4.40470058
53urinary tract smooth muscle contraction (GO:0014848)4.36774173
54nucleotide transmembrane transport (GO:1901679)4.35272204
55UV protection (GO:0009650)4.34058267
56DNA replication checkpoint (GO:0000076)4.33606765
57mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.32969081
58maturation of SSU-rRNA (GO:0030490)4.23302168
59phosphatidylglycerol biosynthetic process (GO:0006655)4.22256514
60presynaptic membrane organization (GO:0097090)4.20629243
61mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.20241329
62purine nucleotide transport (GO:0015865)4.13001743
63nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.10821069
64sphingomyelin metabolic process (GO:0006684)4.04745146
65peristalsis (GO:0030432)4.03460156
66melanin biosynthetic process (GO:0042438)4.03013637
67protein complex disassembly (GO:0043241)3.97863811
68GTP biosynthetic process (GO:0006183)3.97753794
69sulfur amino acid catabolic process (GO:0000098)3.97660380
70postsynaptic membrane organization (GO:0001941)3.96375445
71cilium or flagellum-dependent cell motility (GO:0001539)3.92497034
72G-protein coupled purinergic receptor signaling pathway (GO:0035588)3.91391142
73sphingosine metabolic process (GO:0006670)3.90544678
74ribosomal small subunit assembly (GO:0000028)3.87104407
75translational initiation (GO:0006413)3.84875685
76macromolecular complex disassembly (GO:0032984)3.83280470
77negative regulation of interleukin-8 production (GO:0032717)3.80091795
78regulation of protein kinase A signaling (GO:0010738)3.78721779
79ATP synthesis coupled proton transport (GO:0015986)3.77611324
80energy coupled proton transport, down electrochemical gradient (GO:0015985)3.77611324
81folic acid metabolic process (GO:0046655)3.76519294
82cellular anion homeostasis (GO:0030002)3.71979579
83melanin metabolic process (GO:0006582)3.69065848
84regulation of heat generation (GO:0031650)3.67445909
85grooming behavior (GO:0007625)3.67445458
86phosphate ion homeostasis (GO:0055062)3.67219158
87trivalent inorganic anion homeostasis (GO:0072506)3.67219158
88diol metabolic process (GO:0034311)3.65900398
89sex determination (GO:0007530)3.62901632
90peptidyl-glutamic acid modification (GO:0018200)3.61789285
91mannose metabolic process (GO:0006013)3.60756227
92chaperone-mediated protein transport (GO:0072321)3.59787775
93regulation of nuclear cell cycle DNA replication (GO:0033262)3.59384835
94histone phosphorylation (GO:0016572)3.54656402
95semaphorin-plexin signaling pathway (GO:0071526)3.52649622
96dolichol-linked oligosaccharide biosynthetic process (GO:0006488)3.52633087
97DNA damage response, detection of DNA damage (GO:0042769)3.46156888
98cardiolipin metabolic process (GO:0032048)3.45812200
99respiratory electron transport chain (GO:0022904)3.45733771
100neuromuscular synaptic transmission (GO:0007274)3.44254750
101ribonucleoside bisphosphate biosynthetic process (GO:0034030)3.43222568
102nucleoside bisphosphate biosynthetic process (GO:0033866)3.43222568
103purine nucleoside bisphosphate biosynthetic process (GO:0034033)3.43222568
104purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.42169969
1053-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.42169969
106protein neddylation (GO:0045116)3.40317416
107electron transport chain (GO:0022900)3.35889542
108transcription elongation from RNA polymerase III promoter (GO:0006385)3.34455616
109termination of RNA polymerase III transcription (GO:0006386)3.34455616
110secondary metabolite biosynthetic process (GO:0044550)3.33496298
111DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.33024001
112tooth mineralization (GO:0034505)3.32200277
113mitochondrion distribution (GO:0048311)3.31920609
114cranial nerve morphogenesis (GO:0021602)3.31537524
115nucleoside transport (GO:0015858)3.28582981
116proline biosynthetic process (GO:0006561)3.26578187
117tRNA modification (GO:0006400)3.25416393
118sialylation (GO:0097503)3.23596746
119phosphate ion transmembrane transport (GO:0035435)3.23087060
120type B pancreatic cell proliferation (GO:0044342)3.22403418
121UTP biosynthetic process (GO:0006228)3.22106833
122phosphatidylethanolamine biosynthetic process (GO:0006646)3.21334733
123heme transport (GO:0015886)3.20520104
124protein targeting to membrane (GO:0006612)3.20351989
125positive regulation of synapse assembly (GO:0051965)3.19866097
126translation (GO:0006412)3.12254987
127limb bud formation (GO:0060174)3.11101960
128reciprocal meiotic recombination (GO:0007131)3.10567442
129reciprocal DNA recombination (GO:0035825)3.10567442
130iron coordination entity transport (GO:1901678)3.10052251
131folic acid transport (GO:0015884)3.08847746
132activation of adenylate cyclase activity (GO:0007190)3.08072223
133DNA damage response, signal transduction resulting in transcription (GO:0042772)3.04008633
134positive regulation of gastrulation (GO:2000543)3.03721146
135protein complex biogenesis (GO:0070271)3.03078674
136protein insertion into membrane (GO:0051205)3.02787597
137regulation of meiosis (GO:0040020)3.02595003
138negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)3.02366188
139purine deoxyribonucleotide catabolic process (GO:0009155)3.01420938
140negative regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0045736)3.00925905
141protein import into peroxisome matrix (GO:0016558)2.99227993
142sphingoid metabolic process (GO:0046519)2.97751604
143positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.94412986
144neuron recognition (GO:0008038)2.92459856
145endocytic recycling (GO:0032456)2.91978796
146respiratory chain complex IV assembly (GO:0008535)2.91711589
147base-excision repair, AP site formation (GO:0006285)2.90234006
148odontogenesis of dentin-containing tooth (GO:0042475)2.90210079
149phosphatidylethanolamine metabolic process (GO:0046337)2.89333126
150spliceosomal complex assembly (GO:0000245)2.88258570
151pattern specification involved in kidney development (GO:0061004)2.84881147
152protein localization to synapse (GO:0035418)2.84693402
153mitochondrial respiratory chain complex assembly (GO:0033108)2.82368756
154long-chain fatty acid biosynthetic process (GO:0042759)2.80077178
155regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.79194715
156neuronal action potential propagation (GO:0019227)2.77983286
157spinal cord association neuron differentiation (GO:0021527)2.77979631
158thalamus development (GO:0021794)2.76291499
159positive regulation of meiosis (GO:0045836)2.75810543
160proteasome assembly (GO:0043248)2.74934761
161positive regulation of odontogenesis (GO:0042482)2.74836946
162regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.74823287
163epithelial cilium movement (GO:0003351)2.74491957
164positive regulation of meiotic cell cycle (GO:0051446)2.72579373
165spliceosomal snRNP assembly (GO:0000387)2.69942321
166lymphoid progenitor cell differentiation (GO:0002320)2.69800229
167forebrain neuron development (GO:0021884)2.69290722
168nuclear-transcribed mRNA catabolic process (GO:0000956)2.66018073
169mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.65597974
170mitochondrial respiratory chain complex I assembly (GO:0032981)2.65597974
171NADH dehydrogenase complex assembly (GO:0010257)2.65597974
172positive regulation of protein homodimerization activity (GO:0090073)2.62709316
173negative regulation of execution phase of apoptosis (GO:1900118)2.62657790
174vocalization behavior (GO:0071625)2.61864046
175regulation of odontogenesis (GO:0042481)2.61560152
176regulation of pigment cell differentiation (GO:0050932)2.59953081
177UTP metabolic process (GO:0046051)2.58730768
178mRNA catabolic process (GO:0006402)2.57869920
179intra-S DNA damage checkpoint (GO:0031573)2.57714741
180regulation of respiratory system process (GO:0044065)2.56448829
181mesenchymal cell differentiation involved in renal system development (GO:2001012)2.53769605
182mesenchymal cell differentiation involved in kidney development (GO:0072161)2.53769605
183regulation of synapse assembly (GO:0051963)2.52861857
184CTP biosynthetic process (GO:0006241)2.52533628
185CTP metabolic process (GO:0046036)2.52533628
186axonal fasciculation (GO:0007413)2.51418823
187guanosine-containing compound biosynthetic process (GO:1901070)2.51322303
188sympathetic nervous system development (GO:0048485)2.50907580
189transmission of nerve impulse (GO:0019226)2.50361397
190regulation of catecholamine metabolic process (GO:0042069)2.49769439
191regulation of dopamine metabolic process (GO:0042053)2.49769439
192regulation of mesenchymal cell apoptotic process (GO:2001053)2.49562969
193lateral sprouting from an epithelium (GO:0060601)2.48034884
194nonmotile primary cilium assembly (GO:0035058)2.44658829
195cilium movement (GO:0003341)2.44607372
196epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.43942158
197DNA ligation (GO:0006266)2.42298028
198forebrain neuron differentiation (GO:0021879)2.41902974
199ribonucleoprotein complex biogenesis (GO:0022613)2.41281763
200developmental pigmentation (GO:0048066)2.41157989

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.41666922
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.61914013
3VDR_21846776_ChIP-Seq_THP-1_Human4.44275194
4TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse3.23498782
5CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.16320809
6P68_20966046_ChIP-Seq_HELA_Human3.14513476
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.10838230
8XRN2_22483619_ChIP-Seq_HELA_Human3.06234530
9JARID2_20064375_ChIP-Seq_MESCs_Mouse3.04894819
10EZH2_27304074_Chip-Seq_ESCs_Mouse2.87139765
11CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.87075044
12BMI1_23680149_ChIP-Seq_NPCS_Mouse2.85489182
13E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.82169038
14LXR_22292898_ChIP-Seq_THP-1_Human2.82076140
15CBX2_27304074_Chip-Seq_ESCs_Mouse2.74839550
16GBX2_23144817_ChIP-Seq_PC3_Human2.70825587
17MAF_26560356_Chip-Seq_TH2_Human2.60900509
18E2F1_20622854_ChIP-Seq_HELA_Human2.46198345
19EED_16625203_ChIP-ChIP_MESCs_Mouse2.44520438
20JARID2_20075857_ChIP-Seq_MESCs_Mouse2.43894740
21SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.43714530
22DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.39544869
23SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.39520016
24BCOR_27268052_Chip-Seq_Bcells_Human2.35295648
25EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.31662081
26BCL6_27268052_Chip-Seq_Bcells_Human2.29381038
27DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.24962396
28PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.22338249
29SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.22178191
30RNF2_18974828_ChIP-Seq_MESCs_Mouse2.20493412
31EZH2_18974828_ChIP-Seq_MESCs_Mouse2.20493412
32MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human2.18732080
33PHF8_20622854_ChIP-Seq_HELA_Human2.18219239
34SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.17481724
35CTCF_27219007_Chip-Seq_Bcells_Human2.16567365
36EZH2_27294783_Chip-Seq_ESCs_Mouse2.11774587
37VDR_24763502_ChIP-Seq_THP-1_Human2.10805882
38SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.09670555
39TAF15_26573619_Chip-Seq_HEK293_Human2.07868011
40RACK7_27058665_Chip-Seq_MCF-7_Human2.07036183
41RARB_24833708_ChIP-Seq_LIVER_Mouse2.05878694
42RARG_19884340_ChIP-ChIP_MEFs_Mouse2.05314335
43GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.04584485
44SUZ12_27294783_Chip-Seq_ESCs_Mouse2.04258669
45TET1_21451524_ChIP-Seq_MESCs_Mouse2.03512893
46CTCF_27219007_Chip-Seq_ERYTHROID_Human2.02998572
47MAF_26560356_Chip-Seq_TH1_Human2.01558822
48RNF2_27304074_Chip-Seq_NSC_Mouse1.95451406
49RARA_24833708_ChIP-Seq_LIVER_Mouse1.95178222
50RXRA_24833708_ChIP-Seq_LIVER_Mouse1.94094463
51TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.92116270
52FOXP1_21924763_ChIP-Seq_HESCs_Human1.90443052
53SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.89917214
54ZFP57_27257070_Chip-Seq_ESCs_Mouse1.89093421
55CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.88577033
56KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.85973236
57RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.85706440
58CTBP1_25329375_ChIP-Seq_LNCAP_Human1.82118922
59CTCF_21964334_Chip-Seq_Bcells_Human1.81813555
60SMC4_20622854_ChIP-Seq_HELA_Human1.80781933
61* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.79783264
62CTBP2_25329375_ChIP-Seq_LNCAP_Human1.78528976
63RNF2_27304074_Chip-Seq_ESCs_Mouse1.75322505
64FOXM1_23109430_ChIP-Seq_U2OS_Human1.74054716
65ELF1_20517297_ChIP-Seq_JURKAT_Human1.70761093
66IGF1R_20145208_ChIP-Seq_DFB_Human1.69843968
67MYC_22102868_ChIP-Seq_BL_Human1.69546054
68TP63_19390658_ChIP-ChIP_HaCaT_Human1.69059877
69KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.66695515
70SA1_27219007_Chip-Seq_ERYTHROID_Human1.66574582
71SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.65634876
72VDR_22108803_ChIP-Seq_LS180_Human1.65037531
73CTCF_20526341_ChIP-Seq_ESCs_Human1.63330596
74YY1_22570637_ChIP-Seq_MALME-3M_Human1.61795711
75SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.60344887
76FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.59205316
77SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.58563065
78SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.58388312
79MTF2_20144788_ChIP-Seq_MESCs_Mouse1.57732265
80HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.57017728
81CTCF_21964334_ChIP-Seq_BJAB-B_Human1.56867946
82* FUS_26573619_Chip-Seq_HEK293_Human1.56817326
83ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.55851998
84TP53_22127205_ChIP-Seq_IMR90_Human1.54148209
85GABP_17652178_ChIP-ChIP_JURKAT_Human1.53304615
86CREB1_26743006_Chip-Seq_LNCaP_Human1.52477061
87RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.52317963
88POU5F1_16153702_ChIP-ChIP_HESCs_Human1.51441980
89IRF1_19129219_ChIP-ChIP_H3396_Human1.51337737
90CIITA_25753668_ChIP-Seq_RAJI_Human1.51139208
91HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.50819889
92KDM2B_26808549_Chip-Seq_SUP-B15_Human1.49899710
93* UTX_26944678_Chip-Seq_JUKART_Human1.49312785
94BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.47351315
95KDM2B_26808549_Chip-Seq_DND41_Human1.47342472
96ETS1_20019798_ChIP-Seq_JURKAT_Human1.44921432
97AR_21572438_ChIP-Seq_LNCaP_Human1.44695975
98EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.42519120
99REST_21632747_ChIP-Seq_MESCs_Mouse1.41484515
100FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.41316267
101* ERA_21632823_ChIP-Seq_H3396_Human1.39387730
102GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.39092542
103ETS1_21867929_ChIP-Seq_TH2_Mouse1.35567866
104GABP_19822575_ChIP-Seq_HepG2_Human1.34961357
105E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.34647320
106DCP1A_22483619_ChIP-Seq_HELA_Human1.34466937
107SRY_22984422_ChIP-ChIP_TESTIS_Rat1.34047726
108SA1_27219007_Chip-Seq_Bcells_Human1.31921261
109NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.30828174
110E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.30517589
111JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.30468996
112EST1_17652178_ChIP-ChIP_JURKAT_Human1.30293600
113MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.27085819
114NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.26596429
115EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.25737399
116PU.1_20513432_ChIP-Seq_Bcells_Mouse1.25551798
117TP53_20018659_ChIP-ChIP_R1E_Mouse1.23057447
118CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.22935308
119TCF7_22412390_ChIP-Seq_EML_Mouse1.21309680
120IKZF1_21737484_ChIP-ChIP_HCT116_Human1.19613886
121PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.18828487
122PCGF2_27294783_Chip-Seq_ESCs_Mouse1.18221077
123P300_27268052_Chip-Seq_Bcells_Human1.17559710
124RING1B_27294783_Chip-Seq_ESCs_Mouse1.16978114
125NANOG_20526341_ChIP-Seq_ESCs_Human1.16211935
126ATF3_27146783_Chip-Seq_COLON_Human1.15765100
127POU3F2_20337985_ChIP-ChIP_501MEL_Human1.15006583
128CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.14268318
129STAT6_21828071_ChIP-Seq_BEAS2B_Human1.14109266
130DNAJC2_21179169_ChIP-ChIP_NT2_Human1.13639979
131P53_21459846_ChIP-Seq_SAOS-2_Human1.13607111
132ER_23166858_ChIP-Seq_MCF-7_Human1.13587542
133ELK3_25401928_ChIP-Seq_HUVEC_Human1.13424554
134RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.12628436
135P300_19829295_ChIP-Seq_ESCs_Human1.11931951
136SMAD3_21741376_ChIP-Seq_EPCs_Human1.11873475
137NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.11825058
138ELF1_17652178_ChIP-ChIP_JURKAT_Human1.11557589
139JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.10625503
140TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.10487737
141RING1B_27294783_Chip-Seq_NPCs_Mouse1.09907399
142REST_18959480_ChIP-ChIP_MESCs_Mouse1.09103515
143KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.07857723
144CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07754372
145PKCTHETA_26484144_Chip-Seq_BREAST_Human1.07518338
146CTCF_26484167_Chip-Seq_Bcells_Mouse1.07249830
147EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.06993824
148SALL1_21062744_ChIP-ChIP_HESCs_Human1.06694105
149ZNF274_21170338_ChIP-Seq_K562_Hela1.05813209
150OCT4_20526341_ChIP-Seq_ESCs_Human1.05406281
151CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.05343533
152UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.04374056
153SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.04028226
154UBF1/2_26484160_Chip-Seq_HMECs_Human1.03831111
155TTF2_22483619_ChIP-Seq_HELA_Human1.03571538
156NANOG_18555785_Chip-Seq_ESCs_Mouse1.02512109
157ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.02334547
158SMC3_22415368_ChIP-Seq_MEFs_Mouse1.02238901
159PPARA_22158963_ChIP-Seq_LIVER_Mouse1.01722983
160ERG_21242973_ChIP-ChIP_JURKAT_Human1.01623236
161MYC_18940864_ChIP-ChIP_HL60_Human1.01374135
162FLI1_27457419_Chip-Seq_LIVER_Mouse1.00443427
163TAF2_19829295_ChIP-Seq_ESCs_Human1.00139418
164PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.00107859
165NOTCH1_21737748_ChIP-Seq_TLL_Human0.99831359
166POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.99594000
167CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.99320232
168YY1_21170310_ChIP-Seq_MESCs_Mouse0.99246327
169NCOR1_26117541_ChIP-Seq_K562_Human0.98613398
170MYC_18555785_ChIP-Seq_MESCs_Mouse0.98511679
171SUZ12_27294783_Chip-Seq_NPCs_Mouse0.98357363
172TOP2B_26459242_ChIP-Seq_MCF-7_Human0.98103873
173CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.97879170
174MYC_19079543_ChIP-ChIP_MESCs_Mouse0.96050319
175P53_22387025_ChIP-Seq_ESCs_Mouse0.93619342
176P300_18555785_Chip-Seq_ESCs_Mouse0.92971638
177ELK1_22589737_ChIP-Seq_MCF10A_Human0.92580881
178SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.92409951
179HTT_18923047_ChIP-ChIP_STHdh_Human0.92156117
180EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.91568110
181TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.91385929
182NFE2_27457419_Chip-Seq_LIVER_Mouse0.90851239
183SUZ12_18555785_Chip-Seq_ESCs_Mouse0.90159941
184* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.89862572
185* EWS_26573619_Chip-Seq_HEK293_Human0.89497097
186RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.89297948
187TAL1_26923725_Chip-Seq_HPCs_Mouse0.88881905
188OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.86632202
189MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.85283911
190FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.83770126
191UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.83583841
192JUN_21703547_ChIP-Seq_K562_Human0.83479525
193E2F1_18555785_Chip-Seq_ESCs_Mouse0.83205196

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005171_absent_coat_pigmentation8.09669575
2MP0003880_abnormal_central_pattern5.29831675
3MP0009379_abnormal_foot_pigmentation4.63312039
4MP0002102_abnormal_ear_morphology3.19134524
5MP0008875_abnormal_xenobiotic_pharmacok2.95684625
6MP0001188_hyperpigmentation2.91369511
7MP0005083_abnormal_biliary_tract2.91296354
8MP0005423_abnormal_somatic_nervous2.85008710
9MP0003136_yellow_coat_color2.84363908
10MP0000566_synostosis2.79798323
11MP0006276_abnormal_autonomic_nervous2.75200469
12MP0004381_abnormal_hair_follicle2.74295519
13MP0006292_abnormal_olfactory_placode2.67064185
14MP0000751_myopathy2.54228011
15MP0001756_abnormal_urination2.39069350
16MP0001661_extended_life_span2.39059830
17MP0005409_darkened_coat_color2.36506759
18MP0000778_abnormal_nervous_system2.18453573
19MP0001502_abnormal_circadian_rhythm2.13553686
20MP0001529_abnormal_vocalization2.11375558
21MP0003938_abnormal_ear_development2.04412876
22MP0002160_abnormal_reproductive_system2.02304775
23MP0003315_abnormal_perineum_morphology2.02031920
24MP0004742_abnormal_vestibular_system1.96183152
25MP0000049_abnormal_middle_ear1.90187651
26MP0005257_abnormal_intraocular_pressure1.84136633
27MP0003111_abnormal_nucleus_morphology1.82359906
28MP0005330_cardiomyopathy1.75039888
29MP0000750_abnormal_muscle_regeneration1.71645957
30MP0002638_abnormal_pupillary_reflex1.68967934
31MP0010030_abnormal_orbit_morphology1.66565796
32MP0003453_abnormal_keratinocyte_physiol1.65288946
33MP0001346_abnormal_lacrimal_gland1.61382738
34MP0000462_abnormal_digestive_system1.58995939
35MP0001968_abnormal_touch/_nociception1.58758307
36MP0009250_abnormal_appendicular_skeleto1.58452691
37MP0002751_abnormal_autonomic_nervous1.57674087
38MP0003635_abnormal_synaptic_transmissio1.53662320
39MP0000631_abnormal_neuroendocrine_gland1.52882100
40MP0004130_abnormal_muscle_cell1.51003343
41MP0003011_delayed_dark_adaptation1.50965246
42MP0000026_abnormal_inner_ear1.50417411
43MP0005174_abnormal_tail_pigmentation1.45080792
44MP0002184_abnormal_innervation1.44758157
45MP0004270_analgesia1.44227766
46MP0002938_white_spotting1.44133157
47MP0002272_abnormal_nervous_system1.43705562
48MP0001905_abnormal_dopamine_level1.43313146
49MP0002163_abnormal_gland_morphology1.41507678
50MP0003385_abnormal_body_wall1.36289426
51MP0002734_abnormal_mechanical_nocicepti1.35978130
52MP0004142_abnormal_muscle_tone1.34868620
53MP0005332_abnormal_amino_acid1.33493382
54MP0001486_abnormal_startle_reflex1.31153659
55MP0002572_abnormal_emotion/affect_behav1.31120723
56MP0000013_abnormal_adipose_tissue1.30987360
57MP0009745_abnormal_behavioral_response1.30984850
58MP0006072_abnormal_retinal_apoptosis1.30644246
59MP0002249_abnormal_larynx_morphology1.30059284
60MP0002067_abnormal_sensory_capabilities1.29434376
61MP0002557_abnormal_social/conspecific_i1.28018537
62MP0002064_seizures1.25290967
63MP0005501_abnormal_skin_physiology1.23967406
64MP0002177_abnormal_outer_ear1.23309387
65MP0001919_abnormal_reproductive_system1.22894511
66MP0005645_abnormal_hypothalamus_physiol1.21823688
67MP0000762_abnormal_tongue_morphology1.19869867
68MP0008995_early_reproductive_senescence1.19849190
69MP0002063_abnormal_learning/memory/cond1.19277873
70MP0004043_abnormal_pH_regulation1.18656669
71MP0002752_abnormal_somatic_nervous1.18269551
72MP0004859_abnormal_synaptic_plasticity1.17891374
73MP0005379_endocrine/exocrine_gland_phen1.16358508
74MP0003077_abnormal_cell_cycle1.15924533
75MP0002736_abnormal_nociception_after1.14749148
76MP0000613_abnormal_salivary_gland1.13078434
77MP0003937_abnormal_limbs/digits/tail_de1.12202723
78MP0003122_maternal_imprinting1.11543330
79MP0000015_abnormal_ear_pigmentation1.10371918
80MP0001986_abnormal_taste_sensitivity1.09107309
81MP0010094_abnormal_chromosome_stability1.09053126
82MP0002254_reproductive_system_inflammat1.07402273
83MP0010386_abnormal_urinary_bladder1.07226576
84MP0001765_abnormal_ion_homeostasis1.06458968
85MP0002882_abnormal_neuron_morphology1.06177901
86MP0008789_abnormal_olfactory_epithelium1.06103561
87MP0005646_abnormal_pituitary_gland1.06007792
88MP0005365_abnormal_bile_salt1.05047282
89MP0005551_abnormal_eye_electrophysiolog1.04242272
90MP0001440_abnormal_grooming_behavior1.03574177
91MP0002277_abnormal_respiratory_mucosa1.03549070
92MP0005410_abnormal_fertilization1.02870486
93MP0003693_abnormal_embryo_hatching1.02773054
94MP0004957_abnormal_blastocyst_morpholog1.00414495
95MP0003935_abnormal_craniofacial_develop1.00215622
96MP0002735_abnormal_chemical_nociception0.99397570
97MP0003755_abnormal_palate_morphology0.98734439
98MP0005084_abnormal_gallbladder_morpholo0.98082418
99MP0000467_abnormal_esophagus_morphology0.96523800
100MP0000747_muscle_weakness0.95801619
101MP0000003_abnormal_adipose_tissue0.94509797
102MP0003806_abnormal_nucleotide_metabolis0.93744336
103MP0001963_abnormal_hearing_physiology0.93101819
104MP0003861_abnormal_nervous_system0.92863536
105MP0004145_abnormal_muscle_electrophysio0.91996705
106MP0003705_abnormal_hypodermis_morpholog0.91777313
107MP0009046_muscle_twitch0.91496564
108MP0002116_abnormal_craniofacial_bone0.91018143
109MP0008932_abnormal_embryonic_tissue0.90952196
110MP0004133_heterotaxia0.90688401
111MP0005584_abnormal_enzyme/coenzyme_acti0.90652287
112MP0005076_abnormal_cell_differentiation0.89902438
113MP0000955_abnormal_spinal_cord0.88045427
114MP0004019_abnormal_vitamin_homeostasis0.88023677
115MP0002152_abnormal_brain_morphology0.87940311
116MP0003941_abnormal_skin_development0.87193263
117MP0000470_abnormal_stomach_morphology0.87061267
118MP0001970_abnormal_pain_threshold0.85888025
119MP0001324_abnormal_eye_pigmentation0.85603081
120MP0008569_lethality_at_weaning0.84664678
121MP0005499_abnormal_olfactory_system0.84540816
122MP0005394_taste/olfaction_phenotype0.84540816
123MP0005389_reproductive_system_phenotype0.84054100
124MP0002282_abnormal_trachea_morphology0.83884341
125MP0005253_abnormal_eye_physiology0.81206221
126MP0003878_abnormal_ear_physiology0.80827187
127MP0005377_hearing/vestibular/ear_phenot0.80827187
128MP0002653_abnormal_ependyma_morphology0.80629305
129MP0001286_abnormal_eye_development0.79791741
130MP0001873_stomach_inflammation0.78856710
131MP0001664_abnormal_digestion0.78767380
132MP0002233_abnormal_nose_morphology0.78655698
133MP0002066_abnormal_motor_capabilities/c0.78646763
134MP0000432_abnormal_head_morphology0.78630175
135MP0001958_emphysema0.78221038
136MP0000647_abnormal_sebaceous_gland0.78191700
137MP0001485_abnormal_pinna_reflex0.78009353
138MP0000367_abnormal_coat/_hair0.77695354
139MP0002909_abnormal_adrenal_gland0.77690406
140MP0000538_abnormal_urinary_bladder0.77506681
141MP0001501_abnormal_sleep_pattern0.76936917
142MP0002733_abnormal_thermal_nociception0.75537587
143MP0000358_abnormal_cell_content/0.73720682
144MP0003137_abnormal_impulse_conducting0.71107344
145MP0004185_abnormal_adipocyte_glucose0.70778272
146MP0005220_abnormal_exocrine_pancreas0.70582304
147MP0004215_abnormal_myocardial_fiber0.66738935
148MP0009643_abnormal_urine_homeostasis0.65678985
149MP0001348_abnormal_lacrimal_gland0.65601660
150MP0003448_altered_tumor_morphology0.65276910
151MP0002019_abnormal_tumor_incidence0.62895274
152MP0010771_integument_phenotype0.62273005
153MP0002210_abnormal_sex_determination0.60888044
154MP0009931_abnormal_skin_appearance0.58789427
155MP0004197_abnormal_fetal_growth/weight/0.58233376
156MP0002075_abnormal_coat/hair_pigmentati0.56421572
157MP0001191_abnormal_skin_condition0.51251165
158MP0008770_decreased_survivor_rate0.47883866
159MP0002136_abnormal_kidney_physiology0.47300371
160MP0003091_abnormal_cell_migration0.44542903
161MP0009278_abnormal_bone_marrow0.41586581
162MP0003698_abnormal_male_reproductive0.41563797
163MP0001929_abnormal_gametogenesis0.41090074
164MP0002928_abnormal_bile_duct0.40581539
165MP0002118_abnormal_lipid_homeostasis0.40222306
166MP0005375_adipose_tissue_phenotype0.38422137
167MP0005058_abnormal_lysosome_morphology0.38237976
168MP0003718_maternal_effect0.38169361
169MP0001145_abnormal_male_reproductive0.37510730
170MP0003632_abnormal_nervous_system0.33478141
171MP0002933_joint_inflammation0.32376857
172MP0009840_abnormal_foam_cell0.31966544
173MP0001764_abnormal_homeostasis0.31177453
174MP0010769_abnormal_survival0.31103890
175MP0003303_peritoneal_inflammation0.30876362
176MP0005666_abnormal_adipose_tissue0.30754569
177MP0005448_abnormal_energy_balance0.30752639

Predicted human phenotypes

RankGene SetZ-score
1Amelogenesis imperfecta (HP:0000705)7.57925704
2Testicular atrophy (HP:0000029)6.84808016
3Rib fusion (HP:0000902)6.72846576
4Dyschromatopsia (HP:0007641)5.92169670
5Attenuation of retinal blood vessels (HP:0007843)5.47355232
6Rectovaginal fistula (HP:0000143)5.42272962
7Rectal fistula (HP:0100590)5.42272962
8Poikiloderma (HP:0001029)5.16771463
9Intestinal fistula (HP:0100819)5.07743227
10Vaginal fistula (HP:0004320)4.92116331
11Mesangial abnormality (HP:0001966)4.79638323
12Abnormality of the intrinsic pathway (HP:0010989)4.69042432
13Facial hemangioma (HP:0000329)4.66484375
14Popliteal pterygium (HP:0009756)4.61693425
15Thin bony cortex (HP:0002753)4.60512704
16Annular pancreas (HP:0001734)4.59954658
17Reticulocytopenia (HP:0001896)4.53710231
18Concave nail (HP:0001598)4.52933156
19Ulnar bowing (HP:0003031)4.50555023
20Facial diplegia (HP:0001349)4.31112326
21Congenital stationary night blindness (HP:0007642)4.30859274
22Aplasia/Hypoplasia involving the carpal bones (HP:0006502)4.27768160
23Akinesia (HP:0002304)4.23661344
24Prolonged partial thromboplastin time (HP:0003645)4.20924136
25Turricephaly (HP:0000262)4.18118627
26Joint hemorrhage (HP:0005261)4.02307355
27Aplasia of the musculature (HP:0100854)3.88552868
28Hemorrhage of the eye (HP:0011885)3.86418098
29Increased hepatocellular lipid droplets (HP:0006565)3.83332047
30Acute necrotizing encephalopathy (HP:0006965)3.81323445
31Mitochondrial inheritance (HP:0001427)3.79422851
32Fetal akinesia sequence (HP:0001989)3.77960381
33Choroideremia (HP:0001139)3.73924250
34Squamous cell carcinoma (HP:0002860)3.65563892
35Bony spicule pigmentary retinopathy (HP:0007737)3.60864676
36Patellar aplasia (HP:0006443)3.48864753
37Delayed epiphyseal ossification (HP:0002663)3.47786328
38Chorioretinal atrophy (HP:0000533)3.45914726
39Aplasia/Hypoplasia of the sacrum (HP:0008517)3.36904526
40Anteriorly placed anus (HP:0001545)3.34950107
41Fragile nails (HP:0001808)3.34299196
42Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.32617664
43Decreased central vision (HP:0007663)3.32229012
44Abnormal albumin level (HP:0012116)3.32004370
45Hypoalbuminemia (HP:0003073)3.32004370
46Abnormal mitochondria in muscle tissue (HP:0008316)3.28207003
47Decreased electroretinogram (ERG) amplitude (HP:0000654)3.24021527
48Macrocytic anemia (HP:0001972)3.21657170
49Aplasia/Hypoplasia of the patella (HP:0006498)3.20935953
50Hepatocellular necrosis (HP:0001404)3.20381589
51Short chin (HP:0000331)3.20221134
52Renal Fanconi syndrome (HP:0001994)3.19974510
53Atrioventricular block (HP:0001678)3.14455646
54Lipid accumulation in hepatocytes (HP:0006561)3.13595653
55Progressive macrocephaly (HP:0004481)3.10957755
56Pallor (HP:0000980)3.03091150
57Abnormality of the costochondral junction (HP:0000919)3.02936750
58Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.00858393
59Dynein arm defect of respiratory motile cilia (HP:0012255)2.97324463
60Absent/shortened dynein arms (HP:0200106)2.97324463
61Increased CSF lactate (HP:0002490)2.95029863
62Myotonia (HP:0002486)2.94841012
63Onycholysis (HP:0001806)2.92741581
64Capillary hemangiomas (HP:0005306)2.86572365
65Hypophosphatemic rickets (HP:0004912)2.82872122
66Enlarged epiphyses (HP:0010580)2.81352815
67Parakeratosis (HP:0001036)2.80768091
68Absent thumb (HP:0009777)2.79556675
69Broad-based gait (HP:0002136)2.76514611
70Abnormality of cells of the erythroid lineage (HP:0012130)2.75762274
71Optic disc pallor (HP:0000543)2.73775969
72Acute encephalopathy (HP:0006846)2.67848995
73Zonular cataract (HP:0010920)2.66027883
743-Methylglutaconic aciduria (HP:0003535)2.63784679
75Birth length less than 3rd percentile (HP:0003561)2.57687901
76Abnormality of dental color (HP:0011073)2.55784230
77Increased muscle lipid content (HP:0009058)2.54575814
78Widely patent fontanelles and sutures (HP:0004492)2.53516558
79Aplasia/Hypoplasia involving the musculature (HP:0001460)2.53084598
80Abnormal ciliary motility (HP:0012262)2.51640221
81Aplasia/hypoplasia of the uterus (HP:0008684)2.50507729
82Neonatal respiratory distress (HP:0002643)2.49993726
83Neonatal onset (HP:0003623)2.48777197
84Exertional dyspnea (HP:0002875)2.47341354
85Choanal stenosis (HP:0000452)2.46095351
86Abnormal respiratory motile cilium morphology (HP:0005938)2.45253116
87Abnormal respiratory epithelium morphology (HP:0012253)2.45253116
88Abnormal number of erythroid precursors (HP:0012131)2.45211920
89Horseshoe kidney (HP:0000085)2.43421324
90Premature graying of hair (HP:0002216)2.43307870
91Bowing of the arm (HP:0006488)2.38818828
92Bowed forearm bones (HP:0003956)2.38818828
93Duplication of thumb phalanx (HP:0009942)2.38735387
94Triphalangeal thumb (HP:0001199)2.33717789
95Flat occiput (HP:0005469)2.33199665
96Aplasia cutis congenita (HP:0001057)2.32154127
97Nephronophthisis (HP:0000090)2.32019102
98Joint stiffness (HP:0001387)2.30453583
99Abnormal epiphyseal ossification (HP:0010656)2.30255460
100Short humerus (HP:0005792)2.29246250
101Sensory axonal neuropathy (HP:0003390)2.28249800
102Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.27713098
103Abnormality of the common coagulation pathway (HP:0010990)2.27068855
104Increased number of teeth (HP:0011069)2.26634787
105Narrow nasal bridge (HP:0000446)2.25094293
106Absent rod-and cone-mediated responses on ERG (HP:0007688)2.24378403
107Respiratory difficulties (HP:0002880)2.23993238
108Septo-optic dysplasia (HP:0100842)2.22193949
109Absent radius (HP:0003974)2.21275582
110Increased intramyocellular lipid droplets (HP:0012240)2.21082457
111Hyperthyroidism (HP:0000836)2.20440059
112Hepatic necrosis (HP:0002605)2.20364913
113Secondary amenorrhea (HP:0000869)2.20110736
114Basal cell carcinoma (HP:0002671)2.19042146
115Abnormal respiratory motile cilium physiology (HP:0012261)2.18786409
116Malignant hyperthermia (HP:0002047)2.18459947
117Abnormality of renal resorption (HP:0011038)2.18281629
118Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.16940928
119Focal motor seizures (HP:0011153)2.15056358
120Cerebral hypomyelination (HP:0006808)2.11123949
121Long clavicles (HP:0000890)2.09331460
122Thin ribs (HP:0000883)2.09273044
123Aplasia/hypoplasia of the humerus (HP:0006507)2.08776865
124Thickened helices (HP:0000391)2.07871345
125Aplasia involving forearm bones (HP:0009822)2.07456554
126Absent forearm bone (HP:0003953)2.07456554
127Ridged nail (HP:0001807)2.06305729
128Partial duplication of the phalanx of hand (HP:0009999)2.06175886
129Abnormal drinking behavior (HP:0030082)2.05508542
130Polydipsia (HP:0001959)2.05508542
131Hypoplastic pelvis (HP:0008839)2.04325797
132Partial duplication of thumb phalanx (HP:0009944)2.04250303
133Sex reversal (HP:0012245)2.04222380
134Abnormal sex determination (HP:0012244)2.04222380
135Atelectasis (HP:0100750)2.03894600
136Diminished movement (HP:0002374)2.03061936
137Abnormal pupillary function (HP:0007686)2.01537240
138Fibular aplasia (HP:0002990)2.01530269
139Pterygium (HP:0001059)2.00682117
140Leukodystrophy (HP:0002415)2.00458980
141Seborrheic dermatitis (HP:0001051)1.99855266
142Abnormality of the septum pellucidum (HP:0007375)1.98821574
143Epiphyseal stippling (HP:0010655)1.98008998
144Hypoplasia of the pons (HP:0012110)1.97551916
145Cystic hygroma (HP:0000476)1.96759310
146Alacrima (HP:0000522)1.95989069
147Medial flaring of the eyebrow (HP:0010747)1.95171956
148Reduced antithrombin III activity (HP:0001976)1.94781187
149Amniotic constriction ring (HP:0009775)1.94173717
150Abnormality of placental membranes (HP:0011409)1.94173717
151Short thumb (HP:0009778)1.93962259
152Abnormality of the hepatic vasculature (HP:0006707)1.93587192
153Decreased lacrimation (HP:0000633)1.92871498
154Increased serum lactate (HP:0002151)1.92870520
155Hyperphosphaturia (HP:0003109)1.91682118
156Heart block (HP:0012722)1.91504777
157Agitation (HP:0000713)1.89050776
158Progressive external ophthalmoplegia (HP:0000590)1.88653109
159Myopathic facies (HP:0002058)1.88450673
160Pendular nystagmus (HP:0012043)1.88029497
161Sleep apnea (HP:0010535)1.87804066
162Split foot (HP:0001839)1.87702222
163Nasolacrimal duct obstruction (HP:0000579)1.87427548
164Male infertility (HP:0003251)1.86815012
165Hypoparathyroidism (HP:0000829)1.86581408
166Exercise intolerance (HP:0003546)1.86272473
167Macular degeneration (HP:0000608)1.86236399
168Absent septum pellucidum (HP:0001331)1.84064814
169Abnormal hemoglobin (HP:0011902)1.83744927
170Respiratory failure (HP:0002878)1.83076224
171Abnormal urine phosphate concentration (HP:0012599)1.82872334
172Esotropia (HP:0000565)1.82784277
173Thyroid-stimulating hormone excess (HP:0002925)1.80882858
174Overfolded helix (HP:0000396)1.77956863
175Polyphagia (HP:0002591)1.76726238
176Congenital sensorineural hearing impairment (HP:0008527)1.76454895
177Retinal dysplasia (HP:0007973)1.74557647
178Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.72759312
179Decreased activity of mitochondrial respiratory chain (HP:0008972)1.72759312
180X-linked dominant inheritance (HP:0001423)1.70489701
181Coronal craniosynostosis (HP:0004440)1.70352986
182Delusions (HP:0000746)1.67185552
183Humeroradial synostosis (HP:0003041)1.66077122
184Synostosis involving the elbow (HP:0003938)1.66077122
185Chin dimple (HP:0010751)1.65208484
186Atrophic scars (HP:0001075)1.63591425
187Optic nerve hypoplasia (HP:0000609)1.61858841
188Meningocele (HP:0002435)1.61228705

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK17.15127860
2CASK4.54471711
3STK162.91284311
4MKNK22.49740898
5CDK192.48363983
6EIF2AK12.47196072
7TNIK2.44383236
8STK392.38993392
9ZAK2.24814375
10NME12.09009382
11PNCK1.98011111
12MAP2K71.97606286
13BUB11.96378761
14SRPK11.80770015
15SIK21.76024128
16NME21.76021630
17GRK61.70564370
18CCNB11.68880433
19ACVR1B1.62337772
20NTRK31.62014219
21OXSR11.57054069
22MARK11.56169108
23IRAK11.54997192
24DYRK21.54102994
25WNK11.50793564
26IRAK21.45684541
27MKNK11.44339345
28MAPK131.44058792
29BMPR1B1.43565530
30FES1.36666531
31UHMK11.31628871
32CDK81.31420641
33TRIB31.28411549
34BCR1.26802650
35EPHA41.26139295
36ERN11.23121124
37PKN11.21979143
38WNK31.20217949
39VRK11.16249411
40PDPK11.15611668
41GRK71.15155313
42WNK41.13516837
43IRAK41.13452444
44CDK41.11026723
45MAP3K41.10916105
46PIM21.08453800
47NEK21.06907795
48MAP2K31.04863405
49MAP3K121.04234724
50PRKD21.01974702
51EPHB20.99694738
52ARAF0.98388723
53DYRK30.98257877
54TRIM280.96529293
55CDK60.96480838
56INSRR0.96314897
57CAMK2B0.93701277
58CSNK1G30.93354798
59CDK30.92887916
60DYRK1A0.91222693
61CSNK1G10.90859232
62CDK90.90633296
63ZAP700.90475984
64DAPK30.90331348
65MAP2K60.88531077
66TESK20.86808360
67SIK10.86440810
68PBK0.85889266
69MUSK0.84371180
70PDK20.83340069
71CAMK1D0.83329624
72BMX0.81342224
73MAPK150.77872423
74MAPK110.74450430
75CAMK2A0.73993284
76PRKD10.73301018
77CHEK20.72911806
78ADRBK10.71908950
79EEF2K0.70689302
80ATR0.68815462
81PRPF4B0.68461829
82CLK10.67535666
83CSK0.67151692
84NTRK20.65786967
85PAK10.65470347
86PLK10.63156720
87MARK20.63144925
88TBK10.62679797
89CDK140.61498169
90YES10.60770756
91LIMK10.60176557
92MELK0.58975099
93CSNK1G20.58264957
94CDK11A0.58047284
95CSNK1A1L0.57435528
96FGR0.55751286
97BRAF0.55020338
98ROCK20.54986664
99RPS6KA20.54290157
100PRKAA10.53276686
101CSNK1D0.52558963
102PRKD30.51409138
103CDK150.51187195
104DAPK20.51137191
105CDK180.51115832
106RPS6KA60.50959192
107MAPKAPK50.50714823
108CDK50.50462328
109MINK10.48863238
110PRKCE0.48136124
111CAMK10.47564036
112RPS6KA50.47035650
113MAPK80.46476911
114MAP3K60.46334024
115MAPK120.46090776
116CAMK2D0.45511641
117CSNK1A10.44733002
118CSNK1E0.44161665
119DYRK1B0.42044409
120AURKA0.40417516
121MAP2K40.39141588
122TGFBR10.38988295
123RAF10.38859003
124CSNK2A20.38793618
125PRKCI0.38729323
126RPS6KL10.38593128
127RPS6KC10.38593128
128CAMK1G0.38126279
129IRAK30.37873137
130BLK0.36574958
131MTOR0.36403416
132MAPK40.35718909
133NEK60.35381565
134PRKACA0.35176671
135CAMK2G0.34353910
136GRK50.34115136
137PRKCG0.33976523
138ADRBK20.33750168
139SGK2230.33387579
140SGK4940.33387579
141CSNK2A10.32981965
142NLK0.32883653
143ICK0.32326684
144CDK10.32127426
145IKBKB0.31585700
146STK110.29551694
147GRK10.28376708
148MST40.27420370
149BMPR20.25054784
150MST1R0.23895138
151AKT20.23547647
152MAP4K10.23086678
153IKBKE0.22990569
154MAPK90.22331521
155CDK20.22177699
156PRKG10.21683092
157NUAK10.21398092
158GSK3B0.16437412
159PRKCQ0.16329196
160TNK20.15309317
161CDK120.13215986
162PKN20.13134153
163PIM10.12744344
164LYN0.12590589
165MAPK140.12557927
166RPS6KA10.10762244
167PRKCA0.09785465
168BRSK20.09701328

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006047.26250430
2Ribosome_Homo sapiens_hsa030105.58529576
3Oxidative phosphorylation_Homo sapiens_hsa001904.23978064
4Parkinsons disease_Homo sapiens_hsa050123.29848323
5RNA polymerase_Homo sapiens_hsa030202.90693539
6Protein export_Homo sapiens_hsa030602.82647281
7Alzheimers disease_Homo sapiens_hsa050102.75492824
8Fructose and mannose metabolism_Homo sapiens_hsa000512.63821378
9Glycosaminoglycan degradation_Homo sapiens_hsa005312.61990285
10Huntingtons disease_Homo sapiens_hsa050162.56200871
11Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.50026987
12Nicotine addiction_Homo sapiens_hsa050332.42613572
13Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.94341874
14Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.86724629
15Cardiac muscle contraction_Homo sapiens_hsa042601.85159324
16Spliceosome_Homo sapiens_hsa030401.77115165
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.75828984
18Circadian rhythm_Homo sapiens_hsa047101.72473974
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.68937300
20Proteasome_Homo sapiens_hsa030501.65789484
21Homologous recombination_Homo sapiens_hsa034401.60124167
22Sulfur relay system_Homo sapiens_hsa041221.53780337
23Axon guidance_Homo sapiens_hsa043601.51697461
24Phototransduction_Homo sapiens_hsa047441.51359629
25Taste transduction_Homo sapiens_hsa047421.44603098
26Sphingolipid metabolism_Homo sapiens_hsa006001.44101152
27Fanconi anemia pathway_Homo sapiens_hsa034601.42037982
28Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.41082918
29Collecting duct acid secretion_Homo sapiens_hsa049661.40544367
30Basal transcription factors_Homo sapiens_hsa030221.37884031
31Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.32394239
32Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.32262820
33Serotonergic synapse_Homo sapiens_hsa047261.30024148
34Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.29218486
35Vitamin digestion and absorption_Homo sapiens_hsa049771.26265666
36Ether lipid metabolism_Homo sapiens_hsa005651.23563949
37Long-term depression_Homo sapiens_hsa047301.23357435
38Glutamatergic synapse_Homo sapiens_hsa047241.23218285
39Pyrimidine metabolism_Homo sapiens_hsa002401.20153786
40Hedgehog signaling pathway_Homo sapiens_hsa043401.15822080
41Basal cell carcinoma_Homo sapiens_hsa052171.11939624
42Morphine addiction_Homo sapiens_hsa050321.11358737
43Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.06857223
44Vibrio cholerae infection_Homo sapiens_hsa051101.03415319
45Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.03261063
46Nucleotide excision repair_Homo sapiens_hsa034201.01919741
47Mismatch repair_Homo sapiens_hsa034300.96080945
48GABAergic synapse_Homo sapiens_hsa047270.91112527
49Purine metabolism_Homo sapiens_hsa002300.89720594
50Wnt signaling pathway_Homo sapiens_hsa043100.89342090
51Melanogenesis_Homo sapiens_hsa049160.87241735
52Amphetamine addiction_Homo sapiens_hsa050310.85569038
53Ovarian steroidogenesis_Homo sapiens_hsa049130.85242180
54DNA replication_Homo sapiens_hsa030300.84516576
55Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.84045369
56Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.83244424
57Fatty acid elongation_Homo sapiens_hsa000620.82473496
58Linoleic acid metabolism_Homo sapiens_hsa005910.81267130
59Arachidonic acid metabolism_Homo sapiens_hsa005900.80701702
602-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.80682179
61Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.80463224
62Lysine degradation_Homo sapiens_hsa003100.79501208
63Dopaminergic synapse_Homo sapiens_hsa047280.78589135
64Pyruvate metabolism_Homo sapiens_hsa006200.77620084
65Steroid biosynthesis_Homo sapiens_hsa001000.76107951
66Inositol phosphate metabolism_Homo sapiens_hsa005620.75949098
67Alcoholism_Homo sapiens_hsa050340.75167583
68Cocaine addiction_Homo sapiens_hsa050300.74665844
69Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.73753190
70Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.71313764
71Circadian entrainment_Homo sapiens_hsa047130.70536027
72Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.70294653
73mRNA surveillance pathway_Homo sapiens_hsa030150.69935246
74Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.69829182
75Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.69360145
76Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.68616594
77Synaptic vesicle cycle_Homo sapiens_hsa047210.68527759
78mTOR signaling pathway_Homo sapiens_hsa041500.66887943
79Long-term potentiation_Homo sapiens_hsa047200.65177428
80Base excision repair_Homo sapiens_hsa034100.65089688
81Carbohydrate digestion and absorption_Homo sapiens_hsa049730.63365726
82Salivary secretion_Homo sapiens_hsa049700.63167298
83Gap junction_Homo sapiens_hsa045400.59785142
84Renin secretion_Homo sapiens_hsa049240.58422629
85Autoimmune thyroid disease_Homo sapiens_hsa053200.57982297
86Lysosome_Homo sapiens_hsa041420.57822524
87Insulin secretion_Homo sapiens_hsa049110.56119828
88Primary bile acid biosynthesis_Homo sapiens_hsa001200.55973652
89Cholinergic synapse_Homo sapiens_hsa047250.55921077
90Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.55106187
91Calcium signaling pathway_Homo sapiens_hsa040200.54793039
92N-Glycan biosynthesis_Homo sapiens_hsa005100.54476126
93Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.54373500
94Hippo signaling pathway_Homo sapiens_hsa043900.53863920
95Systemic lupus erythematosus_Homo sapiens_hsa053220.53792232
96alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.53374134
97SNARE interactions in vesicular transport_Homo sapiens_hsa041300.53120913
98Chemical carcinogenesis_Homo sapiens_hsa052040.52821436
99RNA transport_Homo sapiens_hsa030130.51777775
100Steroid hormone biosynthesis_Homo sapiens_hsa001400.50180438
101Cell cycle_Homo sapiens_hsa041100.47236636
102Oocyte meiosis_Homo sapiens_hsa041140.46764231
103GnRH signaling pathway_Homo sapiens_hsa049120.46729175
104Non-homologous end-joining_Homo sapiens_hsa034500.46183159
105Maturity onset diabetes of the young_Homo sapiens_hsa049500.45876776
106Glycerophospholipid metabolism_Homo sapiens_hsa005640.44451634
107Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.40464141
108Metabolic pathways_Homo sapiens_hsa011000.40416116
109Bladder cancer_Homo sapiens_hsa052190.38509368
110Oxytocin signaling pathway_Homo sapiens_hsa049210.37563430
111Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.37261339
112Nitrogen metabolism_Homo sapiens_hsa009100.37151701
113RNA degradation_Homo sapiens_hsa030180.36767347
114ECM-receptor interaction_Homo sapiens_hsa045120.36499387
115Ras signaling pathway_Homo sapiens_hsa040140.35564019
116Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.34885481
117Vascular smooth muscle contraction_Homo sapiens_hsa042700.34849085
118Fatty acid biosynthesis_Homo sapiens_hsa000610.34623321
119Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.34456690
120Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.34198384
121Sphingolipid signaling pathway_Homo sapiens_hsa040710.33409841
122Olfactory transduction_Homo sapiens_hsa047400.33091696
123Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.32732355
124Asthma_Homo sapiens_hsa053100.32397381
125Rheumatoid arthritis_Homo sapiens_hsa053230.32036990
126One carbon pool by folate_Homo sapiens_hsa006700.31337934
127Glutathione metabolism_Homo sapiens_hsa004800.31086503
128Other glycan degradation_Homo sapiens_hsa005110.31006403
129Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.29019087
130Arginine biosynthesis_Homo sapiens_hsa002200.28832123
131Melanoma_Homo sapiens_hsa052180.28797432
132Insulin resistance_Homo sapiens_hsa049310.27848488
133ABC transporters_Homo sapiens_hsa020100.27250467
134Gastric acid secretion_Homo sapiens_hsa049710.26769797
135Fat digestion and absorption_Homo sapiens_hsa049750.26027950
136Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.25973379
137Biosynthesis of amino acids_Homo sapiens_hsa012300.25933505
138Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.25802771
139Allograft rejection_Homo sapiens_hsa053300.25428706
140Endocytosis_Homo sapiens_hsa041440.23667917
141PPAR signaling pathway_Homo sapiens_hsa033200.20457959
142Glycerolipid metabolism_Homo sapiens_hsa005610.18542925
143Fatty acid degradation_Homo sapiens_hsa000710.18481068
144Longevity regulating pathway - mammal_Homo sapiens_hsa042110.16323310
145VEGF signaling pathway_Homo sapiens_hsa043700.13157097
146Primary immunodeficiency_Homo sapiens_hsa053400.11614208
147Selenocompound metabolism_Homo sapiens_hsa004500.10652944
148Notch signaling pathway_Homo sapiens_hsa043300.09246718
149Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.08277334
150RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.07625411
151Peroxisome_Homo sapiens_hsa041460.07341975
152Sulfur metabolism_Homo sapiens_hsa009200.07322748
153Drug metabolism - other enzymes_Homo sapiens_hsa009830.06859336
154Adipocytokine signaling pathway_Homo sapiens_hsa049200.06528533
155Bile secretion_Homo sapiens_hsa049760.06500669
156Mineral absorption_Homo sapiens_hsa049780.05897253
157Aldosterone synthesis and secretion_Homo sapiens_hsa049250.05183894
158Hematopoietic cell lineage_Homo sapiens_hsa046400.04713313

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