ACRBP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is similar to proacrosin binding protein sp32 precursor found in mouse, guinea pig, and pig. This protein is located in the sperm acrosome and is thought to function as a binding protein to proacrosin for packaging and condensation of the acrosin zymogen in the acrosomal matrix. This protein is a member of the cancer/testis family of antigens and it is found to be immunogenic. In normal tissues, this mRNA is expressed only in testis, whereas it is detected in a range of different tumor types such as bladder, breast, lung, liver, and colon. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm motility (GO:0030317)9.25237204
2regulation of cilium movement (GO:0003352)9.17223224
3cilium or flagellum-dependent cell motility (GO:0001539)8.84717142
4acrosome assembly (GO:0001675)7.92752985
5sperm-egg recognition (GO:0035036)7.88437907
6multicellular organism reproduction (GO:0032504)7.82050095
7acrosome reaction (GO:0007340)7.76476003
8axonemal dynein complex assembly (GO:0070286)7.66602143
9plasma membrane fusion (GO:0045026)7.58951284
10neutrophil activation involved in immune response (GO:0002283)7.48215337
11motile cilium assembly (GO:0044458)7.25234588
12binding of sperm to zona pellucida (GO:0007339)7.19574291
13cell wall macromolecule catabolic process (GO:0016998)7.19043638
14cell wall macromolecule metabolic process (GO:0044036)7.19043638
15piRNA metabolic process (GO:0034587)7.15282196
16spermatid development (GO:0007286)7.06635922
17cell-cell recognition (GO:0009988)7.02831923
18epithelial cilium movement (GO:0003351)6.90932447
19thrombin receptor signaling pathway (GO:0070493)6.64046966
20male meiosis (GO:0007140)6.40496794
21polyketide metabolic process (GO:0030638)6.37415729
22doxorubicin metabolic process (GO:0044598)6.37415729
23daunorubicin metabolic process (GO:0044597)6.37415729
24reproduction (GO:0000003)6.37379193
25protein neddylation (GO:0045116)6.15588850
26cilium movement (GO:0003341)6.02925956
27single fertilization (GO:0007338)6.02691258
28synaptonemal complex organization (GO:0070193)5.91787343
29ventricular system development (GO:0021591)5.75526911
30synaptonemal complex assembly (GO:0007130)5.73605762
31epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.71583599
32regulation of platelet aggregation (GO:0090330)5.61499878
33regulation of response to osmotic stress (GO:0047484)5.46171224
34microtubule severing (GO:0051013)5.40917067
35regulation of microtubule-based movement (GO:0060632)5.35798753
36organic cation transport (GO:0015695)5.29398484
37regulation of platelet activation (GO:0010543)5.26594463
38leukocyte migration involved in inflammatory response (GO:0002523)5.17539982
39fertilization (GO:0009566)5.13890358
40adenosine receptor signaling pathway (GO:0001973)5.10452848
41antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.01597290
42positive regulation of endothelial cell differentiation (GO:0045603)4.87186345
43sperm capacitation (GO:0048240)4.84521876
44positive regulation of mast cell activation (GO:0033005)4.79204731
45spermatogenesis (GO:0007283)4.76499033
46male gamete generation (GO:0048232)4.75058605
47blood coagulation, intrinsic pathway (GO:0007597)4.73910780
48platelet aggregation (GO:0070527)4.65628131
49neutrophil activation (GO:0042119)4.62840865
50protein polyglutamylation (GO:0018095)4.58890151
51negative regulation of thymocyte apoptotic process (GO:0070244)4.57756164
52DNA methylation involved in gamete generation (GO:0043046)4.55674772
53lipoxygenase pathway (GO:0019372)4.54209473
54male meiosis I (GO:0007141)4.53316357
55negative regulation of homotypic cell-cell adhesion (GO:0034111)4.47637018
56seminiferous tubule development (GO:0072520)4.42072983
57polyamine biosynthetic process (GO:0006596)4.41826902
58negative regulation of inclusion body assembly (GO:0090084)4.38613191
59gamete generation (GO:0007276)4.36010644
60chromosome condensation (GO:0030261)4.35619664
61heterochromatin organization (GO:0070828)4.32877948
62triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.27611178
63negative regulation of platelet activation (GO:0010544)4.25980769
64G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)4.19769607
65maintenance of protein location in nucleus (GO:0051457)4.17944373
66germ cell development (GO:0007281)4.13695365
67DNA packaging (GO:0006323)4.12536978
68purinergic nucleotide receptor signaling pathway (GO:0035590)4.11766992
69granulocyte activation (GO:0036230)4.09699091
70meiotic nuclear division (GO:0007126)4.09565890
71cellular process involved in reproduction in multicellular organism (GO:0022412)4.05074976
72protein localization to cilium (GO:0061512)4.03671539
73negative regulation of norepinephrine secretion (GO:0010700)4.00772820
74microtubule depolymerization (GO:0007019)3.98427253
75nuclear pore complex assembly (GO:0051292)3.98288904
76negative regulation of heart rate (GO:0010459)3.98287798
77chromosome organization involved in meiosis (GO:0070192)3.97962773
78aminoglycoside antibiotic metabolic process (GO:0030647)3.96226935
79negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)3.91893357
80regulation of integrin-mediated signaling pathway (GO:2001044)3.86295067
81protein localization to chromosome, centromeric region (GO:0071459)3.77518495
82angiogenesis involved in wound healing (GO:0060055)3.75007749
83meiotic cell cycle (GO:0051321)3.74623597
84meiosis I (GO:0007127)3.72847508
85regulation of inclusion body assembly (GO:0090083)3.72698710
86regulation of T-helper 2 cell differentiation (GO:0045628)3.71368712
87histone H4-K12 acetylation (GO:0043983)3.68338020
88DNA replication-dependent nucleosome assembly (GO:0006335)3.66721418
89DNA replication-dependent nucleosome organization (GO:0034723)3.66721418
90negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.66091780
91leukocyte degranulation (GO:0043299)3.65115206
92megakaryocyte development (GO:0035855)3.64433644
93genitalia morphogenesis (GO:0035112)3.64155727
94regulation of integrin activation (GO:0033623)3.63970737
95purinergic receptor signaling pathway (GO:0035587)3.62937427
96regulation of MHC class II biosynthetic process (GO:0045346)3.60805874
97regulation of telomere maintenance via telomerase (GO:0032210)3.59888487
98histone H4-K5 acetylation (GO:0043981)3.59070119
99histone H4-K8 acetylation (GO:0043982)3.59070119
100somite rostral/caudal axis specification (GO:0032525)3.57540719
101negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.50479063
102negative regulation of cell cycle G2/M phase transition (GO:1902750)3.48330750
103regulation of mast cell degranulation (GO:0043304)3.48319405
104platelet degranulation (GO:0002576)3.47756634
105positive regulation of macrophage differentiation (GO:0045651)3.46960571
106low-density lipoprotein particle remodeling (GO:0034374)3.44418124
107G-protein coupled purinergic receptor signaling pathway (GO:0035588)3.43524279
108positive regulation of mast cell activation involved in immune response (GO:0033008)3.43143989
109positive regulation of mast cell degranulation (GO:0043306)3.43143989
110multicellular organismal reproductive process (GO:0048609)3.42950109
111positive regulation of cAMP-mediated signaling (GO:0043950)3.42383519
112regulation of mast cell activation (GO:0033003)3.40124399
113mitotic sister chromatid segregation (GO:0000070)3.39594460
114platelet formation (GO:0030220)3.36871167
115negative regulation of epidermis development (GO:0045683)3.35985856
116termination of G-protein coupled receptor signaling pathway (GO:0038032)3.35843763
117RNA localization (GO:0006403)3.35670791
118regulation of mast cell activation involved in immune response (GO:0033006)3.35097643
119termination of signal transduction (GO:0023021)3.33702125
120homotypic cell-cell adhesion (GO:0034109)3.32215443
121nuclear pore organization (GO:0006999)3.30475158
122platelet activation (GO:0030168)3.30469477
123peptide catabolic process (GO:0043171)3.30005577
124interferon-gamma secretion (GO:0072643)3.29678805
125regulation of homotypic cell-cell adhesion (GO:0034110)3.29364330
126regulation of endothelial cell differentiation (GO:0045601)3.25651558
127glycolytic process (GO:0006096)3.24356217
128cell recognition (GO:0008037)3.24331855
129nucleus organization (GO:0006997)3.21514713
130myeloid cell activation involved in immune response (GO:0002275)3.20272216
131chromatin assembly (GO:0031497)3.19831957
132hormone catabolic process (GO:0042447)3.19345193
133negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.11546946
134negative regulation of T-helper cell differentiation (GO:0045623)3.11546946
135positive regulation of systemic arterial blood pressure (GO:0003084)3.10122585
136cellular biogenic amine biosynthetic process (GO:0042401)3.10076630
137negative regulation of response to food (GO:0032096)3.10056374
138negative regulation of appetite (GO:0032099)3.10056374
139regulation of lipoprotein metabolic process (GO:0050746)3.09452338
140regulation of mammary gland epithelial cell proliferation (GO:0033599)3.08318667
141negative regulation of T cell apoptotic process (GO:0070233)3.08090933
142negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.07956013
143protein-DNA complex disassembly (GO:0032986)3.07596764
144nucleosome disassembly (GO:0006337)3.07596764
145positive regulation of receptor recycling (GO:0001921)3.06943401
146pore complex assembly (GO:0046931)3.05690155
147gene silencing by RNA (GO:0031047)3.03857627
148negative regulation of telomerase activity (GO:0051974)3.03838641
149calcium ion-dependent exocytosis (GO:0017156)3.02043223
150protein localization to kinetochore (GO:0034501)2.99825641
151muscle organ morphogenesis (GO:0048644)2.99740732
152negative regulation of heart contraction (GO:0045822)2.98380886
153positive regulation of type 2 immune response (GO:0002830)2.98118820
154multicellular organismal development (GO:0007275)2.97910694
155regulation of Golgi to plasma membrane protein transport (GO:0042996)2.97151761
156rRNA transcription (GO:0009303)2.95245141
157regulation of nuclear cell cycle DNA replication (GO:0033262)2.95041015
158negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.94991255
159autophagic vacuole fusion (GO:0000046)2.93774582
160single strand break repair (GO:0000012)2.93682098
161rRNA methylation (GO:0031167)2.92760670
162amine biosynthetic process (GO:0009309)2.92436021
163negative regulation of neural precursor cell proliferation (GO:2000178)2.91924736
164beta-amyloid metabolic process (GO:0050435)2.89581704
165positive regulation of blood coagulation (GO:0030194)2.88988454
166positive regulation of hemostasis (GO:1900048)2.88988454
167left/right pattern formation (GO:0060972)2.88597639
168regulation of macrophage derived foam cell differentiation (GO:0010743)2.86666317
169positive regulation of granulocyte differentiation (GO:0030854)2.85429442
170histone H4-K16 acetylation (GO:0043984)2.82941050
171regulation of cytokine production involved in inflammatory response (GO:1900015)2.80951696
172mitochondrial calcium ion transport (GO:0006851)2.80286992
173sister chromatid segregation (GO:0000819)2.78510551
174regulation of regulatory T cell differentiation (GO:0045589)2.78404530
175regulation of norepinephrine secretion (GO:0014061)2.78167652
176positive regulation of Rho protein signal transduction (GO:0035025)2.77182569
177mast cell activation (GO:0045576)2.76001988
178microglial cell activation (GO:0001774)2.75464208
179regulation of myeloid leukocyte mediated immunity (GO:0002886)2.73659873
180regulation of histone H3-K9 methylation (GO:0051570)2.72555543
181negative regulation of protein localization to cell surface (GO:2000009)2.71541790
182regulated secretory pathway (GO:0045055)2.71298751
183Arp2/3 complex-mediated actin nucleation (GO:0034314)2.70769830
184extracellular fibril organization (GO:0043206)2.70747552
185superoxide anion generation (GO:0042554)2.68871985
186pyrimidine nucleoside catabolic process (GO:0046135)2.67812069
187positive regulation of B cell mediated immunity (GO:0002714)2.67113571
188positive regulation of immunoglobulin mediated immune response (GO:0002891)2.67113571
189monoamine transport (GO:0015844)2.67092902
190spermatid nucleus differentiation (GO:0007289)2.66742948
191vesicle targeting (GO:0006903)2.65820176
192phagocytosis, engulfment (GO:0006911)2.62930841
193fusion of sperm to egg plasma membrane (GO:0007342)10.1520434

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.72934081
2* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human4.43499336
3KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.21912740
4KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.21912740
5KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.21912740
6SCL_19346495_ChIP-Seq_HPC-7_Human3.83690102
7LYL1_20887958_ChIP-Seq_HPC-7_Mouse3.81500981
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.27852386
9RUNX1_20887958_ChIP-Seq_HPC-7_Mouse3.17638806
10* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.96044393
11GATA1_19941826_ChIP-Seq_K562_Human2.94377314
12BP1_19119308_ChIP-ChIP_Hs578T_Human2.84896532
13IRF8_21731497_ChIP-ChIP_J774_Mouse2.83420615
14NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.79013015
15LMO2_20887958_ChIP-Seq_HPC-7_Mouse2.68543517
16NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.57303274
17* SPI1_23127762_ChIP-Seq_K562_Human2.52442970
18TP63_19390658_ChIP-ChIP_HaCaT_Human2.49253431
19GATA1_19941827_ChIP-Seq_MEL_Mouse2.38952792
20GATA2_19941826_ChIP-Seq_K562_Human2.38711632
21SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.28956551
22FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.21539083
23IKZF1_21737484_ChIP-ChIP_HCT116_Human2.11064012
24GATA2_20887958_ChIP-Seq_HPC-7_Mouse2.10528100
25Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.09295847
26STAT6_21828071_ChIP-Seq_BEAS2B_Human2.05667523
27TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse2.05495362
28MYB_21317192_ChIP-Seq_ERMYB_Mouse2.00364753
29STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.99218736
30GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.98499053
31RUNX_20019798_ChIP-Seq_JUKART_Human1.98437777
32GATA2_21666600_ChIP-Seq_HMVEC_Human1.97026847
33IRF8_27001747_Chip-Seq_BMDM_Mouse1.96879632
34GATA1_26923725_Chip-Seq_HPCs_Mouse1.96204817
35EZH2_22144423_ChIP-Seq_EOC_Human1.95752947
36IRF1_19129219_ChIP-ChIP_H3396_Human1.94245429
37MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.92876966
38GATA1_22383799_ChIP-Seq_G1ME_Mouse1.92385452
39IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.86524231
40TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.83888011
41RUNX1_22412390_ChIP-Seq_EML_Mouse1.81511799
42* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.81066290
43NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.78707346
44PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.75175867
45TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.74155143
46SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.73122420
47IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.72743047
48RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.70107222
49SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.69969111
50IRF8_22096565_ChIP-ChIP_GC-B_Human1.69105087
51* ELK4_26923725_Chip-Seq_MESODERM_Mouse1.60568570
52GATA1_19941827_ChIP-Seq_MEL86_Mouse1.55312548
53E2F1_17053090_ChIP-ChIP_MCF-7_Human1.53346814
54* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.50492085
55GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.47720162
56* YY1_22570637_ChIP-Seq_MALME-3M_Human1.47500381
57PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.47320670
58ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.46716958
59ELF1_20517297_ChIP-Seq_JURKAT_Human1.45257259
60E2F7_22180533_ChIP-Seq_HELA_Human1.44486143
61SRY_22984422_ChIP-ChIP_TESTIS_Rat1.44115199
62KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.42975755
63* FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.42424184
64* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.37994798
65RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.36884993
66TCF3_18692474_ChIP-Seq_MESCs_Mouse1.35540139
67FOXM1_23109430_ChIP-Seq_U2OS_Human1.35472279
68* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.34503854
69SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.32991277
70E2F4_17652178_ChIP-ChIP_JURKAT_Human1.32825834
71* SPI1_20517297_ChIP-Seq_HL60_Human1.32463791
72SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.31817581
73VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.31051586
74TET1_21451524_ChIP-Seq_MESCs_Mouse1.30537226
75* SPI1_26923725_Chip-Seq_HPCs_Mouse1.29877733
76HTT_18923047_ChIP-ChIP_STHdh_Human1.28136243
77UTX_26944678_Chip-Seq_JUKART_Human1.27871357
78POU5F1_16518401_ChIP-PET_MESCs_Mouse1.27510974
79PHF8_20622854_ChIP-Seq_HELA_Human1.27359606
80SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.27138219
81SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.26457599
82MYB_26560356_Chip-Seq_TH2_Human1.25870972
83SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.25581009
84FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.25429396
85NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.24725484
86GATA3_21867929_ChIP-Seq_CD8_Mouse1.23943901
87SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.23785778
88SPI1_23547873_ChIP-Seq_NB4_Human1.22967274
89GATA2_22383799_ChIP-Seq_G1ME_Mouse1.22798394
90YY1_21170310_ChIP-Seq_MESCs_Mouse1.22302542
91STAT4_19710469_ChIP-ChIP_TH1__Mouse1.22257876
92EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.21550921
93SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.20193680
94CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.20048365
95GATA1_22025678_ChIP-Seq_K562_Human1.19862470
96BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.19793092
97FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.18790428
98RXRA_24833708_ChIP-Seq_LIVER_Mouse1.18350103
99STAT3_18555785_ChIP-Seq_MESCs_Mouse1.17512383
100POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.17234042
101PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.16634807
102TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15994429
103VDR_24763502_ChIP-Seq_THP-1_Human1.15356555
104CDX2_19796622_ChIP-Seq_MESCs_Mouse1.15186960
105GATA3_27048872_Chip-Seq_THYMUS_Human1.15152387
106FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.14979445
107* ESET_19884257_ChIP-Seq_ESCs_Mouse1.14742602
108SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.14645185
109NCOR1_26117541_ChIP-Seq_K562_Human1.14144860
110RARA_24833708_ChIP-Seq_LIVER_Mouse1.13926821
111MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.13902752
112SMC4_20622854_ChIP-Seq_HELA_Human1.12798100
113TP53_22127205_ChIP-Seq_IMR90_Human1.12242409
114STAT3_1855785_ChIP-Seq_MESCs_Mouse1.12093599
115SALL4_22934838_ChIP-ChIP_CD34+_Human1.11768825
116KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.10953956
117EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.10587964
118NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.10349877
119BCOR_27268052_Chip-Seq_Bcells_Human1.10297485
120RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.09960586
121ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.09059471
122GBX2_23144817_ChIP-Seq_PC3_Human1.08841468
123BRD4_27068464_Chip-Seq_AML-cells_Mouse1.08585335
124POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.08323047
125SMRT_27268052_Chip-Seq_Bcells_Human1.08197889
126NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.08044778
127WDR5_24793694_ChIP-Seq_LNCAP_Human1.05674421
128VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.05391056
129TAF15_26573619_Chip-Seq_HEK293_Human1.05056926
130VDR_24787735_ChIP-Seq_THP-1_Human1.03593242
131RNF2_27304074_Chip-Seq_NSC_Mouse1.03453042
132TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.03051578
133SOX2_18555785_ChIP-Seq_MESCs_Mouse1.02691752
134* GATA3_21878914_ChIP-Seq_MCF-7_Human1.02569622
135NANOG_18692474_ChIP-Seq_MESCs_Mouse1.01974455
136P68_20966046_ChIP-Seq_HELA_Human1.01318833
137KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.00470880
138CEBPB_22108803_ChIP-Seq_LS180_Human1.00184750
139GATA3_26560356_Chip-Seq_TH2_Human0.99927766
140TDRD3_21172665_ChIP-Seq_MCF-7_Human0.99199914
141MYC_27129775_Chip-Seq_CORNEA_Mouse0.99034694
142GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98064268
143ERG_20517297_ChIP-Seq_VCAP_Human0.97611757
144STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.97280960
145* P300_27268052_Chip-Seq_Bcells_Human0.96843427
146* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.96212543
147* SOX2_22085726_ChIP-Seq_NPCs_Mouse0.95774659
148UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.94493115
149POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.94420107
150PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94046610
151TCF7_22412390_ChIP-Seq_EML_Mouse0.93851211
152PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.93455221
153FLI1_27457419_Chip-Seq_LIVER_Mouse0.93224088
154NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.93070676
155BCL6_27268052_Chip-Seq_Bcells_Human0.92979518
156ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.92742802
157TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.92674359
158* CTCF_20526341_ChIP-Seq_ESCs_Human0.92045708
159VDR_22108803_ChIP-Seq_LS180_Human0.91019127
160MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.90926639
161SOX2_18692474_ChIP-Seq_MESCs_Mouse0.90154312
162MYB_26560356_Chip-Seq_TH1_Human0.88395126
163CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.88089158
164* OCT1_27270436_Chip-Seq_PROSTATE_Human0.88064136
165NANOG_20526341_ChIP-Seq_ESCs_Human0.87503400
166CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.87471111
167RUNX1_26923725_Chip-Seq_HPCs_Mouse0.87430429
168MAF_26560356_Chip-Seq_TH1_Human0.87249842
169* E2F1_20622854_ChIP-Seq_HELA_Human0.86708758
170STAT1_20625510_ChIP-Seq_HELA_Human0.86627087
171JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.85632862
172RARB_24833708_ChIP-Seq_LIVER_Mouse0.85619433
173ETS1_22383799_ChIP-Seq_G1ME_Mouse0.85449248
174* EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.84563434
175PCGF2_27294783_Chip-Seq_NPCs_Mouse0.84349935
176TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.84131282
177JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.84078885
178CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.84004793
179ETS1_21867929_ChIP-Seq_TH2_Mouse0.83728010
180NANOG_21062744_ChIP-ChIP_HESCs_Human0.83088323
181TAF2_19829295_ChIP-Seq_ESCs_Human0.82091571
182TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.78533983

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005464_abnormal_platelet_physiology8.61567627
2MP0008004_abnormal_stomach_pH4.71953323
3MP0003698_abnormal_male_reproductive4.29557005
4MP0003724_increased_susceptibility_to4.04509968
5MP0001929_abnormal_gametogenesis3.92755984
6MP0003011_delayed_dark_adaptation3.52525166
7MP0008877_abnormal_DNA_methylation3.49730569
8MP0002653_abnormal_ependyma_morphology3.38418791
9MP0000465_gastrointestinal_hemorrhage3.14947673
10MP0006292_abnormal_olfactory_placode3.08416802
11MP0004510_myositis2.93939149
12MP0001835_abnormal_antigen_presentation2.89496620
13MP0003303_peritoneal_inflammation2.87865066
14MP0004264_abnormal_extraembryonic_tissu2.79756863
15MP0008057_abnormal_DNA_replication2.71426544
16MP0002210_abnormal_sex_determination2.70437149
17MP0001145_abnormal_male_reproductive2.58534814
18MP0002161_abnormal_fertility/fecundity2.32148856
19MP0005075_abnormal_melanosome_morpholog2.32008967
20MP0003890_abnormal_embryonic-extraembry2.28592888
21MP0002254_reproductive_system_inflammat2.24239786
22MP0005083_abnormal_biliary_tract2.23315741
23MP0005499_abnormal_olfactory_system2.22911996
24MP0005394_taste/olfaction_phenotype2.22911996
25MP0003436_decreased_susceptibility_to2.17764123
26MP0005671_abnormal_response_to2.04438403
27MP0000343_altered_response_to2.03303200
28MP0000653_abnormal_sex_gland2.02762666
29* MP0005410_abnormal_fertilization10.1747735
30MP0005670_abnormal_white_adipose1.97953274
31MP0005000_abnormal_immune_tolerance1.93221607
32MP0003183_abnormal_peptide_metabolism1.92673040
33MP0002148_abnormal_hypersensitivity_rea1.87088814
34MP0002160_abnormal_reproductive_system1.82173971
35MP0001545_abnormal_hematopoietic_system1.78816994
36MP0005397_hematopoietic_system_phenotyp1.78816994
37MP0000230_abnormal_systemic_arterial1.77986570
38MP0003828_pulmonary_edema1.76097083
39MP0005167_abnormal_blood-brain_barrier1.74087751
40MP0010155_abnormal_intestine_physiology1.67777556
41MP0005058_abnormal_lysosome_morphology1.66444545
42MP0005084_abnormal_gallbladder_morpholo1.63446638
43MP0001293_anophthalmia1.62735257
44MP0002723_abnormal_immune_serum1.61565921
45MP0001800_abnormal_humoral_immune1.61385523
46MP0003315_abnormal_perineum_morphology1.60221141
47MP0002398_abnormal_bone_marrow1.59920846
48MP0004957_abnormal_blastocyst_morpholog1.59491100
49MP0004084_abnormal_cardiac_muscle1.57839406
50MP0002419_abnormal_innate_immunity1.54135313
51MP0008961_abnormal_basal_metabolism1.53713785
52MP0001533_abnormal_skeleton_physiology1.52831421
53MP0003879_abnormal_hair_cell1.52337704
54MP0003638_abnormal_response/metabolism_1.51916515
55MP0002736_abnormal_nociception_after1.50831268
56MP0004858_abnormal_nervous_system1.50309723
57MP0002452_abnormal_antigen_presenting1.49663402
58MP0004947_skin_inflammation1.46703414
59MP0009764_decreased_sensitivity_to1.46261634
60MP0003566_abnormal_cell_adhesion1.44858248
61MP0003122_maternal_imprinting1.43264221
62MP0003121_genomic_imprinting1.43182158
63MP0010094_abnormal_chromosome_stability1.42447911
64MP0005025_abnormal_response_to1.41407936
65MP0002332_abnormal_exercise_endurance1.41256130
66MP0001851_eye_inflammation1.38236662
67MP0006035_abnormal_mitochondrial_morpho1.37545473
68MP0008058_abnormal_DNA_repair1.36943951
69MP0002420_abnormal_adaptive_immunity1.35074807
70MP0003111_abnormal_nucleus_morphology1.33307969
71MP0001819_abnormal_immune_cell1.33169278
72MP0000249_abnormal_blood_vessel1.32636237
73MP0005387_immune_system_phenotype1.31731149
74MP0001790_abnormal_immune_system1.31731149
75MP0001672_abnormal_embryogenesis/_devel1.31408429
76MP0005380_embryogenesis_phenotype1.31408429
77MP0000685_abnormal_immune_system1.28243886
78MP0001879_abnormal_lymphatic_vessel1.25903321
79MP0003787_abnormal_imprinting1.24459562
80MP0004036_abnormal_muscle_relaxation1.23319887
81MP0001968_abnormal_touch/_nociception1.23298034
82MP0001663_abnormal_digestive_system1.22745267
83MP0009785_altered_susceptibility_to1.20553578
84MP0006072_abnormal_retinal_apoptosis1.20493963
85MP0008775_abnormal_heart_ventricle1.19871636
86MP0008872_abnormal_physiological_respon1.19720131
87MP0003300_gastrointestinal_ulcer1.18162437
88MP0002429_abnormal_blood_cell1.17417106
89MP0000689_abnormal_spleen_morphology1.17364861
90MP0002088_abnormal_embryonic_growth/wei1.15919038
91MP0003984_embryonic_growth_retardation1.15201947
92MP0004043_abnormal_pH_regulation1.14745324
93MP0009278_abnormal_bone_marrow1.14312240
94MP0002733_abnormal_thermal_nociception1.13386404
95MP0000678_abnormal_parathyroid_gland1.13320735
96MP0002722_abnormal_immune_system1.13109136
97MP0005257_abnormal_intraocular_pressure1.12787187
98MP0000716_abnormal_immune_system1.12247602
99MP0001845_abnormal_inflammatory_respons1.11736207
100MP0009763_increased_sensitivity_to1.11057906
101MP0003077_abnormal_cell_cycle1.09783837
102MP0003866_abnormal_defecation1.09077429
103MP0005253_abnormal_eye_physiology1.08504127
104MP0004130_abnormal_muscle_cell1.07977280
105MP0005391_vision/eye_phenotype1.07074092
106MP0002092_abnormal_eye_morphology1.03699881
107MP0008874_decreased_physiological_sensi1.02990544
108MP0009765_abnormal_xenobiotic_induced0.99329508
109MP0010329_abnormal_lipoprotein_level0.99214814
110MP0002998_abnormal_bone_remodeling0.95341796
111MP0003786_premature_aging0.94208111
112MP0000858_altered_metastatic_potential0.94196019
113MP0002132_abnormal_respiratory_system0.93123074
114MP0001324_abnormal_eye_pigmentation0.92305334
115MP0005389_reproductive_system_phenotype0.91663244
116MP0006082_CNS_inflammation0.91330341
117MP0002932_abnormal_joint_morphology0.89474867
118MP0008007_abnormal_cellular_replicative0.88721398
119MP0000350_abnormal_cell_proliferation0.88420704
120MP0005535_abnormal_body_temperature0.88389419
121MP0003172_abnormal_lysosome_physiology0.88150821
122MP0010030_abnormal_orbit_morphology0.87804962
123MP0005551_abnormal_eye_electrophysiolog0.86974715
124MP0000313_abnormal_cell_death0.86887072
125MP0002085_abnormal_embryonic_tissue0.86772217
126MP0010352_gastrointestinal_tract_polyps0.86377770
127MP0008789_abnormal_olfactory_epithelium0.86201549
128MP0000015_abnormal_ear_pigmentation0.86071481
129MP0009642_abnormal_blood_homeostasis0.85781264
130MP0002277_abnormal_respiratory_mucosa0.85088750
131MP0003075_altered_response_to0.85032547
132MP0005666_abnormal_adipose_tissue0.84138551
133MP0002114_abnormal_axial_skeleton0.84096453
134MP0004133_heterotaxia0.83712188
135MP0005647_abnormal_sex_gland0.83555658
136MP0002084_abnormal_developmental_patter0.83445324
137MP0009333_abnormal_splenocyte_physiolog0.83085008
138MP0002405_respiratory_system_inflammati0.80975181
139MP0000703_abnormal_thymus_morphology0.79523979
140MP0002127_abnormal_cardiovascular_syste0.78880671
141MP0003718_maternal_effect0.78760370
142MP0003656_abnormal_erythrocyte_physiolo0.78552544
143MP0001970_abnormal_pain_threshold0.76741035
144MP0001849_ear_inflammation0.76717135
145MP0005646_abnormal_pituitary_gland0.76609077
146MP0000049_abnormal_middle_ear0.75325211
147MP0003938_abnormal_ear_development0.74958576
148MP0003119_abnormal_digestive_system0.73694971
149MP0003693_abnormal_embryo_hatching0.73474255
150MP0002735_abnormal_chemical_nociception0.73253644
151MP0004233_abnormal_muscle_weight0.71118677
152MP0004197_abnormal_fetal_growth/weight/0.70857311
153MP0002970_abnormal_white_adipose0.70758286
154MP0000358_abnormal_cell_content/0.69599165
155MP0004484_altered_response_of0.69490091
156MP0001984_abnormal_olfaction0.69460457
157MP0005381_digestive/alimentary_phenotyp0.68835512
158MP0001730_embryonic_growth_arrest0.68401708
159MP0005623_abnormal_meninges_morphology0.68085846
160MP0002086_abnormal_extraembryonic_tissu0.67609672
161MP0000432_abnormal_head_morphology0.67545359
162MP0003123_paternal_imprinting0.66944342
163MP0005266_abnormal_metabolism0.66860029
164MP0004883_abnormal_blood_vessel0.65867560
165MP0001348_abnormal_lacrimal_gland0.64886483
166MP0008770_decreased_survivor_rate0.64042705
167MP0002396_abnormal_hematopoietic_system0.63429915
168MP0005165_increased_susceptibility_to0.61654856
169MP0003861_abnormal_nervous_system0.61592699
170MP0009697_abnormal_copulation0.60985341
171MP0002118_abnormal_lipid_homeostasis0.60931503
172MP0000490_abnormal_crypts_of0.60869659
173MP0003935_abnormal_craniofacial_develop0.60802656
174MP0002233_abnormal_nose_morphology0.60736875
175MP0001697_abnormal_embryo_size0.60450976
176MP0005166_decreased_susceptibility_to0.60390794
177MP0002269_muscular_atrophy0.60243627
178MP0008469_abnormal_protein_level0.59926853
179MP0002080_prenatal_lethality0.59850188
180MP0002282_abnormal_trachea_morphology0.59311494
181MP0003763_abnormal_thymus_physiology0.58926175
182MP0001664_abnormal_digestion0.58456907
183MP0009703_decreased_birth_body0.54004487
184MP0003878_abnormal_ear_physiology0.53979990
185MP0005377_hearing/vestibular/ear_phenot0.53979990
186MP0001727_abnormal_embryo_implantation0.52161031
187MP0001765_abnormal_ion_homeostasis0.52016060
188MP0005310_abnormal_salivary_gland0.51606339
189MP0005195_abnormal_posterior_eye0.51536768

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)9.86981000
2Menorrhagia (HP:0000132)9.67595478
3Increased mean platelet volume (HP:0011877)9.45247949
4Petechiae (HP:0000967)9.15715483
5Abnormal platelet volume (HP:0011876)9.08621574
6Absent/shortened dynein arms (HP:0200106)8.76949838
7Dynein arm defect of respiratory motile cilia (HP:0012255)8.76949838
8Purpura (HP:0000979)8.38302482
9Epistaxis (HP:0000421)7.38890579
10Abnormal respiratory motile cilium physiology (HP:0012261)6.63818403
11Gingival bleeding (HP:0000225)6.33465792
12Abnormal respiratory motile cilium morphology (HP:0005938)6.01496242
13Abnormal respiratory epithelium morphology (HP:0012253)6.01496242
14Nasal polyposis (HP:0100582)5.73294963
15Chronic bronchitis (HP:0004469)5.71013608
16Rhinitis (HP:0012384)5.57536206
17Abnormality of the lower motor neuron (HP:0002366)5.28006595
18Abnormal ciliary motility (HP:0012262)5.22854665
19Hyperlipoproteinemia (HP:0010980)5.17078517
20Abnormal platelet function (HP:0011869)5.09495178
21Impaired platelet aggregation (HP:0003540)5.09495178
22Abnormality of the nasal mucosa (HP:0000433)4.57941606
23Infertility (HP:0000789)4.51673861
24Spontaneous hematomas (HP:0007420)4.35776014
25Bilateral microphthalmos (HP:0007633)4.13809381
26Poikilocytosis (HP:0004447)3.70685172
27Impulsivity (HP:0100710)3.65497463
28Acanthocytosis (HP:0001927)3.55689920
29Bronchitis (HP:0012387)3.52337387
30Bronchiectasis (HP:0002110)3.34038382
31Abnormality of macrophages (HP:0004311)3.30308261
32Amyotrophic lateral sclerosis (HP:0007354)3.25714639
33Bruising susceptibility (HP:0000978)3.20483013
34Nephronophthisis (HP:0000090)3.17122412
35Abnormality of lateral ventricle (HP:0030047)3.12538820
36Conjunctival telangiectasia (HP:0000524)3.08507851
37Abnormal pupillary function (HP:0007686)3.03809675
38Abnormality of the common coagulation pathway (HP:0010990)3.03250430
39Stomatitis (HP:0010280)3.00761655
40Hypochromic microcytic anemia (HP:0004840)3.00643723
41Abnormality of the heme biosynthetic pathway (HP:0010472)2.94887508
42Abnormality of the vasculature of the conjunctiva (HP:0008054)2.83403897
43Rib fusion (HP:0000902)2.83299353
44Chronic obstructive pulmonary disease (HP:0006510)2.82953649
45Obstructive lung disease (HP:0006536)2.82953649
46Ependymoma (HP:0002888)2.81941130
47Increased density of long bones (HP:0006392)2.81805023
48Bifid tongue (HP:0010297)2.81804091
49Paralysis (HP:0003470)2.81524120
50Supernumerary spleens (HP:0009799)2.79132394
51Recurrent otitis media (HP:0000403)2.68955717
52Nephroblastoma (Wilms tumor) (HP:0002667)2.66366784
53Hepatosplenomegaly (HP:0001433)2.66313897
54Male infertility (HP:0003251)2.65845994
55Testicular atrophy (HP:0000029)2.62455664
56Severe visual impairment (HP:0001141)2.61197575
57Dyschromatopsia (HP:0007641)2.59603075
58Molar tooth sign on MRI (HP:0002419)2.59291769
59Abnormality of midbrain morphology (HP:0002418)2.59291769
60Decreased central vision (HP:0007663)2.58763163
61Hepatoblastoma (HP:0002884)2.56971704
62Generalized aminoaciduria (HP:0002909)2.53195958
63Eczematoid dermatitis (HP:0000976)2.45741162
64Short humerus (HP:0005792)2.44201055
65Heterotopia (HP:0002282)2.42299425
66Embryonal renal neoplasm (HP:0011794)2.41817675
67Recurrent sinusitis (HP:0011108)2.39962949
68Aplasia/hypoplasia of the humerus (HP:0006507)2.39891544
69Increased IgM level (HP:0003496)2.39291824
70Abnormality of the phalanges of the hallux (HP:0010057)2.35516466
71Joint swelling (HP:0001386)2.34318632
72Encephalitis (HP:0002383)2.34252551
73Facial cleft (HP:0002006)2.32179625
74Hyperthyroidism (HP:0000836)2.30244345
75Upper motor neuron abnormality (HP:0002127)2.29222958
76Neoplasm of striated muscle (HP:0009728)2.27019576
77Recurrent abscess formation (HP:0002722)2.25733535
78Abnormality of iron homeostasis (HP:0011031)2.25101438
79Abnormality of the renal medulla (HP:0100957)2.24617165
80Chromosomal breakage induced by crosslinking agents (HP:0003221)2.22534766
81Joint hemorrhage (HP:0005261)2.20793540
82Tongue fasciculations (HP:0001308)2.17879159
83Arterial thrombosis (HP:0004420)2.16657935
84Recurrent bacterial skin infections (HP:0005406)2.16560847
85Episodic fever (HP:0001954)2.15615343
86Neoplasm of the heart (HP:0100544)2.15424146
87Abnormal lung lobation (HP:0002101)2.14859004
88Bile duct proliferation (HP:0001408)2.14304579
89Abnormal biliary tract physiology (HP:0012439)2.14304579
90Spastic tetraparesis (HP:0001285)2.13023731
91Rectal fistula (HP:0100590)2.10649150
92Rectovaginal fistula (HP:0000143)2.10649150
93Partial duplication of thumb phalanx (HP:0009944)2.10467185
94Abnormality of transition element cation homeostasis (HP:0011030)2.09351745
95Aplasia/Hypoplasia of the fovea (HP:0008060)2.08324412
96Hypoplasia of the fovea (HP:0007750)2.08324412
97Recurrent bronchitis (HP:0002837)2.06553239
98Intestinal fistula (HP:0100819)2.04183831
99Impaired proprioception (HP:0010831)2.03779657
100Pendular nystagmus (HP:0012043)2.03576878
101Abnormal spermatogenesis (HP:0008669)2.03442124
102Abnormal auditory evoked potentials (HP:0006958)2.01138357
103Multiple enchondromatosis (HP:0005701)2.00848467
104Xanthomatosis (HP:0000991)2.00426920
105Prolonged bleeding time (HP:0003010)11.0517572
106Aplasia/Hypoplasia affecting the retina (HP:0008061)1.99166742
107Polycythemia (HP:0001901)1.98138400
108Tinnitus (HP:0000360)1.97589043
109Postaxial foot polydactyly (HP:0001830)1.96958013
110Chest pain (HP:0100749)1.95760079
111Increased serum ferritin (HP:0003281)1.95556742
112Aplasia/Hypoplasia of the uvula (HP:0010293)1.95168957
113Aplasia/Hypoplasia of the macula (HP:0008059)1.94112460
114Elevated erythrocyte sedimentation rate (HP:0003565)1.93042557
115Abnormality of the astrocytes (HP:0100707)1.92846247
116Astrocytoma (HP:0009592)1.92846247
117Meckel diverticulum (HP:0002245)1.91580264
118Spontaneous abortion (HP:0005268)1.89325428
119Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.89242525
120Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.87652898
121Medial flaring of the eyebrow (HP:0010747)1.85545817
122Abnormality of the ileum (HP:0001549)1.84323982
123Muscle fibrillation (HP:0010546)1.83769502
124Vertigo (HP:0002321)1.83746101
125Ventricular fibrillation (HP:0001663)1.82650856
126Hypophosphatemic rickets (HP:0004912)1.82138674
127Hemiparesis (HP:0001269)1.80613016
128Hypopigmentation of the fundus (HP:0007894)1.80056325
129Sensory axonal neuropathy (HP:0003390)1.79669730
130Leukocytosis (HP:0001974)1.79164222
131Nausea (HP:0002018)1.78643422
132Abnormality of the prostate (HP:0008775)1.77534632
133Chromsome breakage (HP:0040012)1.76861289
134Villous atrophy (HP:0011473)1.76312507
135Abnormality of small intestinal villus morphology (HP:0011472)1.76312507
136Postaxial hand polydactyly (HP:0001162)1.75769561
137Vaginal fistula (HP:0004320)1.75746179
138Myocardial infarction (HP:0001658)1.75740155
139Abnormality of the distal phalanx of the thumb (HP:0009617)1.75454042
140Autoimmune hemolytic anemia (HP:0001890)1.74204676
141Sloping forehead (HP:0000340)1.74155026
142Thrombocytosis (HP:0001894)1.73562887
143Partial duplication of the phalanx of hand (HP:0009999)1.73519374
144Tubular atrophy (HP:0000092)1.73383007
1453-Methylglutaconic aciduria (HP:0003535)1.71790748
146Absent frontal sinuses (HP:0002688)1.71181744
147Hand muscle atrophy (HP:0009130)1.68742297
148Inflammation of the large intestine (HP:0002037)1.68304951
149Anomalous pulmonary venous return (HP:0010772)1.67811339
150Granulocytopenia (HP:0001913)1.65816696
151Congenital hepatic fibrosis (HP:0002612)1.64062730
152Gonadotropin excess (HP:0000837)1.63962113
153Attenuation of retinal blood vessels (HP:0007843)1.62049707
154Rhabdomyosarcoma (HP:0002859)1.61512919
155Basal ganglia calcification (HP:0002135)1.60903650
156Generalized hypotonia (HP:0001290)1.59703560
157Meningitis (HP:0001287)1.59556060
158Myositis (HP:0100614)1.57354642
159Retrobulbar optic neuritis (HP:0100654)1.56710674
160Optic neuritis (HP:0100653)1.56710674
161Abnormality of the fovea (HP:0000493)1.56647910
162Panhypogammaglobulinemia (HP:0003139)1.56164329
163Dysautonomia (HP:0002459)1.55030685
164Eosinophilia (HP:0001880)1.54668858
165Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.53642950
166Oculomotor apraxia (HP:0000657)1.53380489
167Gastrointestinal inflammation (HP:0004386)1.53263105
168Abnormality of the salivary glands (HP:0010286)1.52830316
169Hypertriglyceridemia (HP:0002155)1.52748726
170Thyroid-stimulating hormone excess (HP:0002925)1.51651915
171Hypoplasia of the capital femoral epiphysis (HP:0003090)1.50961725
172Upper limb muscle weakness (HP:0003484)1.49555777
173Short ribs (HP:0000773)1.49177159
174Acute hepatic failure (HP:0006554)1.48769789
175Short thorax (HP:0010306)1.48696135
176Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.48592970
177Abnormality of binocular vision (HP:0011514)1.48138884
178Diplopia (HP:0000651)1.48138884
179Hyperinsulinemic hypoglycemia (HP:0000825)1.47754900
180Small intestinal stenosis (HP:0012848)1.47518244
181Duodenal stenosis (HP:0100867)1.47518244
182Thrombophlebitis (HP:0004418)1.47378461
183Dysostosis multiplex (HP:0000943)1.45035800
184Orchitis (HP:0100796)1.44598437
185Vasculitis (HP:0002633)1.44109301
186Polyphagia (HP:0002591)1.41546554
187Gastrointestinal infarctions (HP:0005244)1.40949453

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK45.99352850
2PDK45.81160854
3PDK35.81160854
4CDK125.61362666
5PDK24.07396384
6MST43.87656927
7BMX3.74562545
8ICK3.61567388
9TESK13.23442926
10ERN13.12999578
11PRKD33.11862787
12GRK63.05100389
13TEC3.04637951
14BTK2.97827478
15GRK52.93428347
16MYLK2.88590789
17PIK3CG2.45750231
18SYK2.41646283
19GRK12.39745861
20TYRO32.33202522
21EIF2AK12.32186266
22TAOK32.14627859
23CSF1R2.13518755
24ZAP702.11531116
25BLK2.00127496
26ADRBK21.95295414
27TTK1.95161732
28BMPR21.95059541
29WNK11.85626978
30NEK21.74505969
31FGR1.71922319
32FES1.66708901
33HCK1.60419222
34PLK21.59763480
35TGFBR21.51777873
36STK101.48498080
37MAP2K31.46965426
38STK391.46458193
39STK381.43504977
40DDR21.40034798
41MAPK71.39372406
42MAP3K101.34200597
43LYN1.33437154
44ILK1.32661357
45PTK2B1.30454081
46GRK71.19947053
47AKT31.19299221
48MARK21.18513984
49CHEK21.17477069
50MATK1.14604668
51CDK71.13269854
52DYRK1B1.11658572
53TXK1.08966780
54MAP4K21.08585461
55MAP2K61.00829970
56ACVR1B1.00743686
57WNK41.00626223
58MAP3K110.98587090
59CDC70.98478513
60ITK0.93798426
61PNCK0.92925675
62PIM20.92818390
63CHEK10.91621128
64MAPKAPK30.90734806
65MARK30.89925841
66ARAF0.89374195
67TESK20.87604537
68SIK30.86290627
69JAK30.85329469
70MAP3K30.84559080
71PDK10.84095153
72PRKG20.82912557
73PLK10.79605151
74DYRK30.78029650
75PAK40.75853817
76CAMK40.73654779
77DAPK30.73621465
78IRAK40.70919235
79MTOR0.69192626
80DAPK20.67486650
81JAK20.65949882
82LCK0.64732514
83CSK0.63461503
84MAP3K50.61936082
85RET0.61689599
86MAPK150.59751337
87MOS0.59021625
88INSRR0.57123443
89MAP3K10.54626513
90PKN10.54567789
91PRKD10.52258089
92FER0.51496127
93EPHA30.49846304
94ATM0.49821221
95ATR0.49518428
96TAOK20.49321192
97PRKG10.48904748
98FYN0.48352165
99TRIM280.47848500
100ADRBK10.47422229
101CAMK1G0.47105837
102ERBB20.46494658
103STK30.45673713
104TNIK0.44218011
105STK240.43168541
106KIT0.42045245
107PRKACG0.41363539
108PRKAA10.41162951
109EPHA20.40446850
110WEE10.40073459
111BRD40.40008932
112TNK20.39977379
113EEF2K0.39898574
114TLK10.39761784
115PRKCQ0.39501310
116CDK20.37345904
117JAK10.36095368
118IRAK30.35817675
119BMPR1B0.35707954
120MAP3K70.34609744
121MAP2K10.34553897
122EPHB10.34460175
123PRKD20.34240502
124HIPK20.33898847
125TBK10.33752931
126CDK40.32553138
127PAK10.32315035
128PDPK10.31595279
129PRKCB0.30962138
130TAOK10.30706235
131PRKCD0.30324246
132NTRK10.30186880
133MAPK120.29514299
134STK38L0.27942542
135NTRK20.27452115
136MAP2K40.27450087
137NUAK10.26514869
138PDGFRB0.26214431
139ROCK10.25572172
140AKT20.24384964
141KSR20.24109246
142IRAK20.23293955
143MINK10.23169409
144GSK3B0.23068407
145PRKCA0.22572979
146SIK20.22561090
147CAMK10.22274936
148PIM10.22080519
149CCNB10.21567904
150CDK10.21531479
151YES10.21323941
152PASK0.20804244
153PRKCI0.19476762
154PLK40.16816931
155LMTK20.14469562
156MAPK100.14305056
157PAK20.14050416
158DYRK1A0.14035104
159EIF2AK20.13783140
160MAPK140.12374190
161PRKCG0.12185817
162SRPK10.12169207
163PRPF4B0.12165516
164AURKB0.12062885
165FGFR30.11980314
166IGF1R0.11795540
167CSNK1E0.11750324
168PRKACB0.11749743
169MAPK10.11622542
170MAP4K10.11040841
171IRAK10.10315200
172PINK10.09775958
173IKBKB0.09753006

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007505.83782252
2Platelet activation_Homo sapiens_hsa046114.87733145
3Fructose and mannose metabolism_Homo sapiens_hsa000514.10922105
4Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006033.91583861
5Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.38674078
6alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.88099747
7Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.85831890
8Linoleic acid metabolism_Homo sapiens_hsa005912.80446210
9SNARE interactions in vesicular transport_Homo sapiens_hsa041302.63981024
10Fanconi anemia pathway_Homo sapiens_hsa034602.58279817
11Hematopoietic cell lineage_Homo sapiens_hsa046402.50666429
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.30783575
13Fatty acid biosynthesis_Homo sapiens_hsa000612.19194013
14mRNA surveillance pathway_Homo sapiens_hsa030152.12296703
15Basal transcription factors_Homo sapiens_hsa030222.10571917
16RNA transport_Homo sapiens_hsa030131.97408167
17Chemokine signaling pathway_Homo sapiens_hsa040621.96338687
18Arachidonic acid metabolism_Homo sapiens_hsa005901.87574069
19Pyruvate metabolism_Homo sapiens_hsa006201.83405627
20Graft-versus-host disease_Homo sapiens_hsa053321.81420518
21Selenocompound metabolism_Homo sapiens_hsa004501.79087038
22Allograft rejection_Homo sapiens_hsa053301.77838681
23Galactose metabolism_Homo sapiens_hsa000521.67228175
24Autoimmune thyroid disease_Homo sapiens_hsa053201.65832564
25Pentose phosphate pathway_Homo sapiens_hsa000301.59412993
26ECM-receptor interaction_Homo sapiens_hsa045121.56675514
27Glycerophospholipid metabolism_Homo sapiens_hsa005641.56203294
28Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.56029362
29Olfactory transduction_Homo sapiens_hsa047401.54575118
30Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.51802007
31Staphylococcus aureus infection_Homo sapiens_hsa051501.51113368
32Nitrogen metabolism_Homo sapiens_hsa009101.50080825
33Endocytosis_Homo sapiens_hsa041441.46363158
34Glycerolipid metabolism_Homo sapiens_hsa005611.45944826
35Osteoclast differentiation_Homo sapiens_hsa043801.45930175
36Pentose and glucuronate interconversions_Homo sapiens_hsa000401.45572298
37Glucagon signaling pathway_Homo sapiens_hsa049221.39306000
38Gap junction_Homo sapiens_hsa045401.38102624
39Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.37763929
40Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.36487245
41Other glycan degradation_Homo sapiens_hsa005111.32639628
42Serotonergic synapse_Homo sapiens_hsa047261.31792933
43Systemic lupus erythematosus_Homo sapiens_hsa053221.29659043
44Glycosaminoglycan degradation_Homo sapiens_hsa005311.29624277
45Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.26015326
46Asthma_Homo sapiens_hsa053101.25513318
47Collecting duct acid secretion_Homo sapiens_hsa049661.24393062
48Type I diabetes mellitus_Homo sapiens_hsa049401.24181859
49Leishmaniasis_Homo sapiens_hsa051401.22199940
50Phagosome_Homo sapiens_hsa041451.21830800
51Malaria_Homo sapiens_hsa051441.21118053
52Cysteine and methionine metabolism_Homo sapiens_hsa002701.16951383
53T cell receptor signaling pathway_Homo sapiens_hsa046601.15590328
54Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.12900660
55Shigellosis_Homo sapiens_hsa051311.12649854
56Propanoate metabolism_Homo sapiens_hsa006401.12152049
57mTOR signaling pathway_Homo sapiens_hsa041501.11403577
58Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.10976715
59Hedgehog signaling pathway_Homo sapiens_hsa043401.10373542
60Alcoholism_Homo sapiens_hsa050341.09643224
61Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.08262930
62Inositol phosphate metabolism_Homo sapiens_hsa005621.05885230
63Viral myocarditis_Homo sapiens_hsa054161.02827284
64Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.02631911
65Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.01639963
66Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.00914360
67Leukocyte transendothelial migration_Homo sapiens_hsa046701.00561255
68RNA degradation_Homo sapiens_hsa030181.00383929
69Toll-like receptor signaling pathway_Homo sapiens_hsa046201.00004041
70Spliceosome_Homo sapiens_hsa030400.99636910
71Intestinal immune network for IgA production_Homo sapiens_hsa046720.98778089
72Pancreatic secretion_Homo sapiens_hsa049720.97862102
73Ether lipid metabolism_Homo sapiens_hsa005650.97482216
74Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.96352511
75Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.95947410
76Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.95778248
77Base excision repair_Homo sapiens_hsa034100.94861918
78Oocyte meiosis_Homo sapiens_hsa041140.94337714
79DNA replication_Homo sapiens_hsa030300.92999959
80Regulation of actin cytoskeleton_Homo sapiens_hsa048100.92290264
81Biosynthesis of amino acids_Homo sapiens_hsa012300.92265938
82Dorso-ventral axis formation_Homo sapiens_hsa043200.91397266
83ABC transporters_Homo sapiens_hsa020100.90404431
84Central carbon metabolism in cancer_Homo sapiens_hsa052300.88463925
85Basal cell carcinoma_Homo sapiens_hsa052170.86312621
86Carbon metabolism_Homo sapiens_hsa012000.83407843
87Homologous recombination_Homo sapiens_hsa034400.82651583
88PPAR signaling pathway_Homo sapiens_hsa033200.82355798
89Tuberculosis_Homo sapiens_hsa051520.81918371
90Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.80950772
91Morphine addiction_Homo sapiens_hsa050320.79232995
92Chemical carcinogenesis_Homo sapiens_hsa052040.78354366
93Transcriptional misregulation in cancer_Homo sapiens_hsa052020.76954086
94Carbohydrate digestion and absorption_Homo sapiens_hsa049730.76549477
95Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.76240437
96Phosphatidylinositol signaling system_Homo sapiens_hsa040700.74106813
97Non-homologous end-joining_Homo sapiens_hsa034500.73779852
98NOD-like receptor signaling pathway_Homo sapiens_hsa046210.73660432
99Long-term depression_Homo sapiens_hsa047300.72770537
100Cell cycle_Homo sapiens_hsa041100.72767375
101Toxoplasmosis_Homo sapiens_hsa051450.70982594
102Circadian entrainment_Homo sapiens_hsa047130.70138104
103Legionellosis_Homo sapiens_hsa051340.68344408
104Sulfur relay system_Homo sapiens_hsa041220.66802199
105Mismatch repair_Homo sapiens_hsa034300.64996737
106Thyroid hormone signaling pathway_Homo sapiens_hsa049190.64867774
107Rheumatoid arthritis_Homo sapiens_hsa053230.64687747
108AMPK signaling pathway_Homo sapiens_hsa041520.63453760
109Mineral absorption_Homo sapiens_hsa049780.62632401
110Jak-STAT signaling pathway_Homo sapiens_hsa046300.62557140
111Taste transduction_Homo sapiens_hsa047420.62168802
112Non-small cell lung cancer_Homo sapiens_hsa052230.61717544
113Pancreatic cancer_Homo sapiens_hsa052120.60240770
114Rap1 signaling pathway_Homo sapiens_hsa040150.59445208
115Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.58032033
116NF-kappa B signaling pathway_Homo sapiens_hsa040640.57830317
117Herpes simplex infection_Homo sapiens_hsa051680.56607155
118Fat digestion and absorption_Homo sapiens_hsa049750.55627464
119Purine metabolism_Homo sapiens_hsa002300.54487089
120Antigen processing and presentation_Homo sapiens_hsa046120.52909670
121Renin secretion_Homo sapiens_hsa049240.51448789
122Focal adhesion_Homo sapiens_hsa045100.51212295
123Measles_Homo sapiens_hsa051620.49608354
124Phospholipase D signaling pathway_Homo sapiens_hsa040720.49064421
125Wnt signaling pathway_Homo sapiens_hsa043100.48073396
126Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.47727539
127Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.47689620
128Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.46335561
129VEGF signaling pathway_Homo sapiens_hsa043700.45475593
130Type II diabetes mellitus_Homo sapiens_hsa049300.44582462
131Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.44569491
132Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.43619957
133Glutathione metabolism_Homo sapiens_hsa004800.43575695
134Cardiac muscle contraction_Homo sapiens_hsa042600.43495110
135Acute myeloid leukemia_Homo sapiens_hsa052210.43168240
136Salmonella infection_Homo sapiens_hsa051320.43136435
137Apoptosis_Homo sapiens_hsa042100.43076899
138Choline metabolism in cancer_Homo sapiens_hsa052310.42957162
139Calcium signaling pathway_Homo sapiens_hsa040200.42344811
140Phototransduction_Homo sapiens_hsa047440.40083357
141B cell receptor signaling pathway_Homo sapiens_hsa046620.39812921
142Ras signaling pathway_Homo sapiens_hsa040140.39793135
143Cholinergic synapse_Homo sapiens_hsa047250.39567157
144Renin-angiotensin system_Homo sapiens_hsa046140.39416205
145Gastric acid secretion_Homo sapiens_hsa049710.38746909
146Amphetamine addiction_Homo sapiens_hsa050310.36931159
147Amoebiasis_Homo sapiens_hsa051460.36123902
148RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.35473987
149Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.35293006
150Endometrial cancer_Homo sapiens_hsa052130.35019163
151Starch and sucrose metabolism_Homo sapiens_hsa005000.34725986
152Longevity regulating pathway - mammal_Homo sapiens_hsa042110.34655698
153Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.34433563
154Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.33380349
155Synaptic vesicle cycle_Homo sapiens_hsa047210.32434855
156Lysine degradation_Homo sapiens_hsa003100.31968703
157Adipocytokine signaling pathway_Homo sapiens_hsa049200.31538633
158Pyrimidine metabolism_Homo sapiens_hsa002400.31513470
159Influenza A_Homo sapiens_hsa051640.31471517
160Primary immunodeficiency_Homo sapiens_hsa053400.31211283
161Metabolic pathways_Homo sapiens_hsa011000.31020876
162Protein digestion and absorption_Homo sapiens_hsa049740.30635855
163One carbon pool by folate_Homo sapiens_hsa006700.30476375
164Thyroid cancer_Homo sapiens_hsa052160.29140457
165Notch signaling pathway_Homo sapiens_hsa043300.27807628
166Vascular smooth muscle contraction_Homo sapiens_hsa042700.25720949
167cGMP-PKG signaling pathway_Homo sapiens_hsa040220.24482663
168Pathways in cancer_Homo sapiens_hsa052000.23347376
169Viral carcinogenesis_Homo sapiens_hsa052030.22291081
170Long-term potentiation_Homo sapiens_hsa047200.20678145

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »