ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	piRNA metabolic process (GO:0034587)	6.72897654
2	synapsis (GO:0007129)	5.93214463
3	male meiosis I (GO:0007141)	5.64721097
4	cell wall macromolecule catabolic process (GO:0016998)	5.23294246
5	male meiosis (GO:0007140)	4.86536887
6	DNA methylation involved in gamete generation (GO:0043046)	4.72074074
7	meiosis I (GO:0007127)	4.68704878
8	cell wall macromolecule metabolic process (GO:0044036)	4.51915428
9	regulation of MHC class II biosynthetic process (GO:0045346)	4.17581817
10	chromosome organization involved in meiosis (GO:0070192)	3.92928340
11	behavioral response to nicotine (GO:0035095)	3.91988097
12	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.78952949
13	reciprocal DNA recombination (GO:0035825)	3.76442674
14	reciprocal meiotic recombination (GO:0007131)	3.76442674
15	organelle membrane fusion (GO:0090174)	3.67403002
16	myelin assembly (GO:0032288)	3.64891854
17	resolution of meiotic recombination intermediates (GO:0000712)	3.63009904
18	regulation of cilium movement (GO:0003352)	3.61157267
19	meiotic nuclear division (GO:0007126)	3.59665959
20	negative regulation of response to food (GO:0032096)	3.57059930
21	negative regulation of appetite (GO:0032099)	3.57059930
22	protein K11-linked deubiquitination (GO:0035871)	3.56745164
23	interkinetic nuclear migration (GO:0022027)	3.50084959
24	negative regulation of telomere maintenance (GO:0032205)	3.48955788
25	DNA deamination (GO:0045006)	3.44426210
26	indolalkylamine metabolic process (GO:0006586)	3.40566127
27	autophagic vacuole fusion (GO:0000046)	3.33386725
28	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.24949016
29	retinal rod cell development (GO:0046548)	3.24654736
30	detection of light stimulus involved in sensory perception (GO:0050962)	3.17040198
31	detection of light stimulus involved in visual perception (GO:0050908)	3.17040198
32	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.14983812
33	nonmotile primary cilium assembly (GO:0035058)	3.14187948
34	regulation of meiosis I (GO:0060631)	3.14082747
35	response to pheromone (GO:0019236)	3.10758718
36	neuron fate determination (GO:0048664)	3.08187181
37	brain morphogenesis (GO:0048854)	3.03569072
38	photoreceptor cell maintenance (GO:0045494)	3.03028038
39	meiotic cell cycle process (GO:1903046)	3.01386929
40	negative regulation of systemic arterial blood pressure (GO:0003085)	2.98572943
41	synaptonemal complex organization (GO:0070193)	2.97853607
42	negative regulation of alpha-beta T cell differentiation (GO:0046639)	2.96335016
43	negative regulation of execution phase of apoptosis (GO:1900118)	2.94073874
44	synaptonemal complex assembly (GO:0007130)	2.93012996
45	cilium morphogenesis (GO:0060271)	2.88517024
46	epithelial cilium movement (GO:0003351)	2.87231439
47	axoneme assembly (GO:0035082)	2.80022939
48	protein prenylation (GO:0018342)	2.78137903
49	prenylation (GO:0097354)	2.78137903
50	regulation of microtubule-based movement (GO:0060632)	2.77716056
51	neural tube formation (GO:0001841)	2.77113916
52	kidney morphogenesis (GO:0060993)	2.75453981
53	auditory receptor cell differentiation (GO:0042491)	2.75448486
54	meiotic chromosome segregation (GO:0045132)	2.73750373
55	rRNA catabolic process (GO:0016075)	2.70070823
56	L-fucose catabolic process (GO:0042355)	2.69912313
57	fucose catabolic process (GO:0019317)	2.69912313
58	L-fucose metabolic process (GO:0042354)	2.69912313
59	recombinational repair (GO:0000725)	2.68666705
60	negative regulation by host of viral transcription (GO:0043922)	2.67810900
61	negative regulation of alpha-beta T cell activation (GO:0046636)	2.66923439
62	auditory receptor cell stereocilium organization (GO:0060088)	2.65833255
63	multicellular organism reproduction (GO:0032504)	2.65788026
64	double-strand break repair via homologous recombination (GO:0000724)	2.65254915
65	retinal cone cell development (GO:0046549)	2.64667974
66	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.63069833
67	microtubule anchoring (GO:0034453)	2.61190634
68	negative regulation of T-helper cell differentiation (GO:0045623)	2.61122677
69	negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)	2.61122677
70	photoreceptor cell development (GO:0042461)	2.57518661
71	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.56438368
72	somite rostral/caudal axis specification (GO:0032525)	2.53919901
73	negative T cell selection (GO:0043383)	2.53200283
74	adenosine metabolic process (GO:0046085)	2.50135158
75	indole-containing compound metabolic process (GO:0042430)	2.48638943
76	positive regulation of defense response to virus by host (GO:0002230)	2.48219108
77	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.47612236
78	sister chromatid cohesion (GO:0007062)	2.47545740
79	centriole replication (GO:0007099)	2.47180792
80	adaptation of signaling pathway (GO:0023058)	2.46841646
81	DNA synthesis involved in DNA repair (GO:0000731)	2.45825661
82	establishment of protein localization to Golgi (GO:0072600)	2.44431751
83	indole-containing compound catabolic process (GO:0042436)	2.44327066
84	indolalkylamine catabolic process (GO:0046218)	2.44327066
85	tryptophan catabolic process (GO:0006569)	2.44327066
86	cellular ketone body metabolic process (GO:0046950)	2.43500608
87	positive regulation of cAMP-mediated signaling (GO:0043950)	2.42086091
88	eye photoreceptor cell development (GO:0042462)	2.41393723
89	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	2.41324723
90	regulation of collateral sprouting (GO:0048670)	2.40348762
91	regulation of memory T cell differentiation (GO:0043380)	2.40242913
92	regulation of telomere maintenance (GO:0032204)	2.37299232
93	detection of chemical stimulus involved in sensory perception of taste (GO:0050912)	2.37294069
94	leukocyte aggregation (GO:0070486)	2.34812773
95	ketone body metabolic process (GO:1902224)	2.33555737
96	positive regulation of granulocyte differentiation (GO:0030854)	2.32664976
97	positive regulation of cellular response to oxidative stress (GO:1900409)	2.30970327
98	positive regulation of response to oxidative stress (GO:1902884)	2.30970327
99	cilium movement (GO:0003341)	2.30311868
100	water-soluble vitamin biosynthetic process (GO:0042364)	2.30269321

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	VDR_22108803_ChIP-Seq_LS180_Human	3.26915154
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.26005975
3	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.85672208
4	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.74734171
5	GBX2_23144817_ChIP-Seq_PC3_Human	2.58558867
6	FUS_26573619_Chip-Seq_HEK293_Human	2.47386793
7	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.39026215
8	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.37910858
9	EWS_26573619_Chip-Seq_HEK293_Human	2.33382049
10	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.29154041
11	ER_23166858_ChIP-Seq_MCF-7_Human	2.20472031
12	TAF15_26573619_Chip-Seq_HEK293_Human	2.17867319
13	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.15688650
14	IGF1R_20145208_ChIP-Seq_DFB_Human	2.14321199
15	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.08740118
16	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.07539040
17	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.98284695
18	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.95285222
19	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.93510130
20	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.88959758
21	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.87686821
22	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.82423344
23	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.81562352
24	P300_19829295_ChIP-Seq_ESCs_Human	1.80156112
25	TP53_22573176_ChIP-Seq_HFKS_Human	1.77677971
26	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.75014826
27	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.68980448
28	ELK1_19687146_ChIP-ChIP_HELA_Human	1.66702948
29	BCAT_22108803_ChIP-Seq_LS180_Human	1.62090364
30	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.61681107
31	VDR_23849224_ChIP-Seq_CD4+_Human	1.59772210
32	EZH2_22144423_ChIP-Seq_EOC_Human	1.56172315
33	GATA3_26560356_Chip-Seq_TH2_Human	1.54532075
34	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.50248332
35	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.48212454
36	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.46845353
37	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.46321730
38	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.45656358
39	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.44879361
40	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.43706398
41	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.43467038
42	CBP_20019798_ChIP-Seq_JUKART_Human	1.43467038
43	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.42623652
44	CDX2_22108803_ChIP-Seq_LS180_Human	1.40393376
45	AR_25329375_ChIP-Seq_VCAP_Human	1.40222821
46	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.40080251
47	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.38047618
48	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.37983071
49	TCF4_23295773_ChIP-Seq_U87_Human	1.37686899
50	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.37414904
51	STAT3_23295773_ChIP-Seq_U87_Human	1.36256886
52	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.35869464
53	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.35869464
54	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.35250976
55	RUNX_20019798_ChIP-Seq_JUKART_Human	1.34338313
56	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.31425185
57	TCF4_22108803_ChIP-Seq_LS180_Human	1.27764579
58	SOX2_19829295_ChIP-Seq_ESCs_Human	1.27740581
59	NANOG_19829295_ChIP-Seq_ESCs_Human	1.27740581
60	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.26956612
61	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.26890651
62	MYC_18940864_ChIP-ChIP_HL60_Human	1.26839317
63	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.26250399
64	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.25467701
65	SMAD4_21799915_ChIP-Seq_A2780_Human	1.23566017
66	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.23516143
67	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.23067991
68	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.23067991
69	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.21770585
70	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.21380498
71	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.19832537
72	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.19610782
73	AR_20517297_ChIP-Seq_VCAP_Human	1.18337829
74	NCOR_22424771_ChIP-Seq_293T_Human	1.17888984
75	RUNX2_22187159_ChIP-Seq_PCA_Human	1.16608757
76	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.16048304
77	SMRT_27268052_Chip-Seq_Bcells_Human	1.15750730
78	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.15160735
79	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.14834453
80	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.14672549
81	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.14353927
82	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.14240965
83	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.14163823
84	HOXB7_26014856_ChIP-Seq_BT474_Human	1.13875928
85	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.13517463
86	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.13387541
87	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.12772728
88	GATA3_26560356_Chip-Seq_TH1_Human	1.10933061
89	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.09741036
90	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.09571790
91	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.09526158
92	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.09497239
93	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.05779218
94	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.04342067
95	TP53_16413492_ChIP-PET_HCT116_Human	1.02441606
96	TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human	1.02224757
97	P53_22387025_ChIP-Seq_ESCs_Mouse	1.02100928
98	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.01796888
99	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.01654608
100	RNF2_27304074_Chip-Seq_NSC_Mouse	1.00430065

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	5.49677330
2	MP0000569_abnormal_digit_pigmentation	2.97898479
3	MP0003787_abnormal_imprinting	2.63704772
4	MP0003011_delayed_dark_adaptation	2.52100508
5	MP0004147_increased_porphyrin_level	2.47491224
6	MP0003880_abnormal_central_pattern	2.43962921
7	MP0003136_yellow_coat_color	2.33954303
8	MP0005551_abnormal_eye_electrophysiolog	2.31040340
9	MP0004885_abnormal_endolymph	2.30152812
10	MP0006292_abnormal_olfactory_placode	2.21932141
11	MP0005671_abnormal_response_to	1.95450994
12	MP0005310_abnormal_salivary_gland	1.94562909
13	MP0002277_abnormal_respiratory_mucosa	1.89767253
14	MP0000372_irregular_coat_pigmentation	1.88696628
15	MP0005174_abnormal_tail_pigmentation	1.88592925
16	MP0000427_abnormal_hair_cycle	1.87085909
17	MP0003195_calcinosis	1.85657308
18	MP0001984_abnormal_olfaction	1.83856280
19	MP0003724_increased_susceptibility_to	1.81499851
20	MP0008789_abnormal_olfactory_epithelium	1.78519427
21	MP0002837_dystrophic_cardiac_calcinosis	1.77850633
22	MP0001986_abnormal_taste_sensitivity	1.73544012
23	MP0004142_abnormal_muscle_tone	1.71366860
24	MP0002210_abnormal_sex_determination	1.68890606
25	MP0002876_abnormal_thyroid_physiology	1.68653330
26	MP0003646_muscle_fatigue	1.65920648
27	MP0001485_abnormal_pinna_reflex	1.62730177
28	MP0001800_abnormal_humoral_immune	1.56817703
29	MP0001929_abnormal_gametogenesis	1.54521672
30	MP0008058_abnormal_DNA_repair	1.52483692
31	MP0008872_abnormal_physiological_respon	1.47549300
32	MP0001968_abnormal_touch/_nociception	1.44707412
33	MP0005646_abnormal_pituitary_gland	1.43419194
34	MP0002638_abnormal_pupillary_reflex	1.41052553
35	MP0004742_abnormal_vestibular_system	1.39928689
36	MP0002102_abnormal_ear_morphology	1.39790044
37	MP0002653_abnormal_ependyma_morphology	1.36945462
38	MP0001502_abnormal_circadian_rhythm	1.35404389
39	MP0003698_abnormal_male_reproductive	1.32762669
40	MP0010030_abnormal_orbit_morphology	1.32600834
41	MP0002938_white_spotting	1.28609514
42	MP0001835_abnormal_antigen_presentation	1.28117396
43	MP0001324_abnormal_eye_pigmentation	1.26268788
44	MP0005389_reproductive_system_phenotype	1.22756831
45	MP0000015_abnormal_ear_pigmentation	1.22641492
46	MP0001145_abnormal_male_reproductive	1.20067274
47	MP0002095_abnormal_skin_pigmentation	1.19806649
48	MP0000653_abnormal_sex_gland	1.18981903
49	MP0005410_abnormal_fertilization	1.17892255
50	MP0002693_abnormal_pancreas_physiology	1.17182800
51	MP0004381_abnormal_hair_follicle	1.14795927
52	MP0001919_abnormal_reproductive_system	1.13224993
53	MP0009745_abnormal_behavioral_response	1.12789157
54	MP0002736_abnormal_nociception_after	1.12613659
55	MP0009785_altered_susceptibility_to	1.12224757
56	MP0008875_abnormal_xenobiotic_pharmacok	1.11869106
57	MP0000631_abnormal_neuroendocrine_gland	1.08807969
58	MP0002723_abnormal_immune_serum	1.06842390
59	MP0005253_abnormal_eye_physiology	1.05985498
60	MP0005075_abnormal_melanosome_morpholog	1.05660336
61	MP0006082_CNS_inflammation	1.04822623
62	MP0001873_stomach_inflammation	1.04126029
63	MP0001119_abnormal_female_reproductive	1.02205046
64	MP0002148_abnormal_hypersensitivity_rea	1.00808896
65	MP0009764_decreased_sensitivity_to	1.00744424
66	MP0002254_reproductive_system_inflammat	1.00316001
67	MP0000230_abnormal_systemic_arterial	0.98019014
68	MP0003763_abnormal_thymus_physiology	0.95273782
69	MP0006072_abnormal_retinal_apoptosis	0.94639321
70	MP0005394_taste/olfaction_phenotype	0.94280315
71	MP0005499_abnormal_olfactory_system	0.94280315
72	MP0001790_abnormal_immune_system	0.94176482
73	MP0005387_immune_system_phenotype	0.94176482
74	MP0002160_abnormal_reproductive_system	0.93898245
75	MP0000685_abnormal_immune_system	0.92788480
76	MP0000383_abnormal_hair_follicle	0.92679222
77	MP0001501_abnormal_sleep_pattern	0.91869930
78	MP0005084_abnormal_gallbladder_morpholo	0.89305683
79	MP0005000_abnormal_immune_tolerance	0.87437979
80	MP0001970_abnormal_pain_threshold	0.86627641
81	MP0002452_abnormal_antigen_presenting	0.86120142
82	MP0003786_premature_aging	0.84670091
83	MP0002067_abnormal_sensory_capabilities	0.84645486
84	MP0005195_abnormal_posterior_eye	0.84480974
85	MP0001188_hyperpigmentation	0.84285956
86	MP0002420_abnormal_adaptive_immunity	0.83676390
87	MP0000566_synostosis	0.83068804
88	MP0002272_abnormal_nervous_system	0.82773671
89	MP0005448_abnormal_energy_balance	0.82327843
90	MP0001819_abnormal_immune_cell	0.80387238
91	MP0000026_abnormal_inner_ear	0.77169009
92	MP0004484_altered_response_of	0.75482298
93	MP0000689_abnormal_spleen_morphology	0.73743553
94	MP0002138_abnormal_hepatobiliary_system	0.73479621
95	MP0004215_abnormal_myocardial_fiber	0.73387469
96	MP0004133_heterotaxia	0.71289704
97	MP0002163_abnormal_gland_morphology	0.70256688
98	MP0008995_early_reproductive_senescence	0.70058462
99	MP0004924_abnormal_behavior	0.68617009
100	MP0005386_behavior/neurological_phenoty	0.68617009

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Congenital stationary night blindness (HP:0007642)	4.71842345
2	Abnormality of midbrain morphology (HP:0002418)	4.40926014
3	Molar tooth sign on MRI (HP:0002419)	4.40926014
4	Pancreatic cysts (HP:0001737)	4.22259031
5	Type II lissencephaly (HP:0007260)	4.18400080
6	Pancreatic fibrosis (HP:0100732)	3.91924366
7	Stomatitis (HP:0010280)	3.85672158
8	Abnormality of the renal cortex (HP:0011035)	3.62882576
9	True hermaphroditism (HP:0010459)	3.56763945
10	Cerebellar dysplasia (HP:0007033)	3.26794933
11	Nephronophthisis (HP:0000090)	3.26224719
12	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	3.15300082
13	Abnormality of alanine metabolism (HP:0010916)	3.15300082
14	Hyperalaninemia (HP:0003348)	3.15300082
15	Medial flaring of the eyebrow (HP:0010747)	2.99794088
16	Tubular atrophy (HP:0000092)	2.89678463
17	Abnormality of the renal medulla (HP:0100957)	2.88750335
18	Azoospermia (HP:0000027)	2.86595836
19	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.71258190
20	Chronic hepatic failure (HP:0100626)	2.57968771
21	Oligodactyly (hands) (HP:0001180)	2.55503109
22	Attenuation of retinal blood vessels (HP:0007843)	2.51142830
23	Absent/shortened dynein arms (HP:0200106)	2.47259894
24	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.47259894
25	Short tibia (HP:0005736)	2.42811137
26	Renal cortical cysts (HP:0000803)	2.42019807
27	Abnormality of DNA repair (HP:0003254)	2.41614841
28	Decreased central vision (HP:0007663)	2.38440809
29	Retinal dysplasia (HP:0007973)	2.35287809
30	Congenital primary aphakia (HP:0007707)	2.30395892
31	Abnormal respiratory motile cilium morphology (HP:0005938)	2.29488450
32	Abnormal respiratory epithelium morphology (HP:0012253)	2.29488450
33	Abnormal ciliary motility (HP:0012262)	2.28309087
34	Cystic liver disease (HP:0006706)	2.28232824
35	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	2.26079433
36	Degeneration of the lateral corticospinal tracts (HP:0002314)	2.26079433
37	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.25678137
38	Gait imbalance (HP:0002141)	2.25349710
39	Abnormal rod and cone electroretinograms (HP:0008323)	2.24635255
40	Abnormal spermatogenesis (HP:0008669)	2.24418331
41	Meckel diverticulum (HP:0002245)	2.17958802
42	Nephrogenic diabetes insipidus (HP:0009806)	2.13394904
43	Hyperventilation (HP:0002883)	2.12185688
44	Large for gestational age (HP:0001520)	2.11187770
45	Poor coordination (HP:0002370)	2.11051614
46	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.10634543
47	Abnormality of the ileum (HP:0001549)	2.09435374
48	Abnormality of chromosome stability (HP:0003220)	2.08284911
49	Male pseudohermaphroditism (HP:0000037)	2.05949202
50	Postaxial foot polydactyly (HP:0001830)	2.05680621
51	Abnormality of T cell number (HP:0011839)	2.02803132
52	Gaze-evoked nystagmus (HP:0000640)	2.02160111
53	Methylmalonic acidemia (HP:0002912)	2.02028505
54	Abnormal drinking behavior (HP:0030082)	2.01842957
55	Polydipsia (HP:0001959)	2.01842957
56	Retrobulbar optic neuritis (HP:0100654)	2.01478591
57	Optic neuritis (HP:0100653)	2.01478591
58	Chronic sinusitis (HP:0011109)	2.01204950
59	Optic nerve hypoplasia (HP:0000609)	2.00751921
60	T lymphocytopenia (HP:0005403)	2.00005054
61	3-Methylglutaconic aciduria (HP:0003535)	1.97224899
62	Congenital hepatic fibrosis (HP:0002612)	1.95554692
63	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.92883040
64	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.91799602
65	Hypoplasia of the fovea (HP:0007750)	1.91799602
66	Septo-optic dysplasia (HP:0100842)	1.89528702
67	Congenital, generalized hypertrichosis (HP:0004540)	1.87596636
68	Genital tract atresia (HP:0001827)	1.86518728
69	Widely spaced teeth (HP:0000687)	1.86371104
70	Abolished electroretinogram (ERG) (HP:0000550)	1.83548759
71	IgG deficiency (HP:0004315)	1.82624071
72	Clubbing of toes (HP:0100760)	1.82427376
73	Oligodactyly (HP:0012165)	1.82199495
74	Abnormal respiratory motile cilium physiology (HP:0012261)	1.81889686
75	Postaxial hand polydactyly (HP:0001162)	1.80509139
76	Furrowed tongue (HP:0000221)	1.80015328
77	Abnormality of vitamin B metabolism (HP:0004340)	1.79138551
78	Gonadotropin excess (HP:0000837)	1.75908498
79	Hypoplastic iliac wings (HP:0002866)	1.74356604
80	Fair hair (HP:0002286)	1.72743040
81	Colon cancer (HP:0003003)	1.69767462
82	Ectopic kidney (HP:0000086)	1.69617071
83	Vaginal atresia (HP:0000148)	1.69189848
84	Increased CSF lactate (HP:0002490)	1.69164370
85	Progressive inability to walk (HP:0002505)	1.68510576
86	Astigmatism (HP:0000483)	1.67756684
87	Abnormality of the preputium (HP:0100587)	1.65471888
88	Acute necrotizing encephalopathy (HP:0006965)	1.65396611
89	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.64577652
90	Absent thumb (HP:0009777)	1.64024414
91	Scotoma (HP:0000575)	1.63092226
92	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.61030797
93	Rib fusion (HP:0000902)	1.59395007
94	Sclerocornea (HP:0000647)	1.59038122
95	Abnormality of the fovea (HP:0000493)	1.58991275
96	Mitochondrial inheritance (HP:0001427)	1.58348472
97	Lissencephaly (HP:0001339)	1.58293520
98	Decreased circulating renin level (HP:0003351)	1.58281189
99	Lipid accumulation in hepatocytes (HP:0006561)	1.57890279
100	Broad-based gait (HP:0002136)	1.57496835

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	3.83161212
2	TAOK3	3.68029983
3	MAP4K2	3.44318421
4	ADRBK2	2.37628935
5	TXK	2.32211693
6	WNK3	2.26183709
7	BRSK2	2.21198509
8	AKT3	2.18906857
9	ACVR1B	2.14804780
10	ZAK	2.13930688
11	IRAK1	2.13277654
12	PNCK	2.01862684
13	MST4	2.01765162
14	EIF2AK3	1.92809336
15	NUAK1	1.92750306
16	BMPR1B	1.86059037
17	WEE1	1.76046167
18	PINK1	1.67954905
19	WNK4	1.67525212
20	TNK2	1.63997817
21	TEC	1.57863025
22	GRK1	1.56141068
23	MAP3K13	1.51813340
24	CAMKK2	1.45645730
25	MAPK13	1.39301890
26	MAP3K9	1.39202354
27	TRIM28	1.38442549
28	PLK2	1.28592182
29	STK39	1.27063235
30	PAK3	1.19777026
31	MAP4K1	1.17908220
32	TAF1	1.10384432
33	PRKCE	1.09316003
34	PTK2B	1.04886150
35	TLK1	1.04115413
36	ITK	1.00678118
37	ADRBK1	0.93425170
38	NLK	0.93295369
39	DYRK3	0.93038304
40	KIT	0.92207184
41	IKBKB	0.92016874
42	MARK3	0.90803414
43	STK38L	0.89665489
44	OXSR1	0.89249460
45	STK3	0.88823531
46	EPHA4	0.87882620
47	INSRR	0.83187646
48	CSF1R	0.82681684
49	VRK1	0.80933190
50	BRD4	0.80838235
51	PRKCQ	0.80076485
52	GRK5	0.78554633
53	DAPK2	0.74224754
54	PIK3CG	0.70560214
55	TGFBR1	0.70225685
56	TSSK6	0.69432337
57	IRAK4	0.66576201
58	KSR1	0.66468098
59	PDK2	0.65571239
60	PASK	0.65220392
61	TNIK	0.65031599
62	BTK	0.64455724
63	SYK	0.62797744
64	BRAF	0.62030607
65	DYRK2	0.59472677
66	GRK7	0.58819433
67	SGK1	0.56235276
68	LYN	0.55813072
69	MKNK2	0.55466982
70	MAP2K6	0.54602360
71	EIF2AK1	0.54222958
72	RPS6KA5	0.53116859
73	CSNK1G2	0.51945031
74	PIK3CA	0.51839301
75	STK11	0.50636243
76	MOS	0.49630777
77	MELK	0.49051092
78	CDK3	0.48859007
79	SGK2	0.48410170
80	PLK3	0.47542030
81	MAP3K12	0.46625746
82	CAMK1	0.45504021
83	WNK1	0.44475067
84	DYRK1A	0.43345714
85	IKBKE	0.39723902
86	FLT3	0.39702259
87	PIM1	0.39274883
88	EIF2AK2	0.39263581
89	CASK	0.36403914
90	CHUK	0.36101617
91	MAP3K4	0.35014433
92	LCK	0.34885985
93	CSNK1G1	0.34671071
94	TRPM7	0.34090525
95	PRKCG	0.33859961
96	IRAK2	0.31296429
97	PRKCI	0.30212675
98	PRKG1	0.30149491
99	ZAP70	0.28430782
100	FES	0.28422999

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Selenocompound metabolism_Homo sapiens_hsa00450	3.30846706
2	Basal transcription factors_Homo sapiens_hsa03022	2.94886000
3	Regulation of autophagy_Homo sapiens_hsa04140	2.65580563
4	Homologous recombination_Homo sapiens_hsa03440	2.63783973
5	Nitrogen metabolism_Homo sapiens_hsa00910	2.41892055
6	Phototransduction_Homo sapiens_hsa04744	2.25303656
7	Primary immunodeficiency_Homo sapiens_hsa05340	2.24832632
8	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.04066801
9	Linoleic acid metabolism_Homo sapiens_hsa00591	1.99024804
10	Fanconi anemia pathway_Homo sapiens_hsa03460	1.97654444
11	Protein export_Homo sapiens_hsa03060	1.91437053
12	Oxidative phosphorylation_Homo sapiens_hsa00190	1.84291595
13	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.78558934
14	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.74386497
15	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.67393943
16	Circadian rhythm_Homo sapiens_hsa04710	1.57399301
17	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.52271811
18	Parkinsons disease_Homo sapiens_hsa05012	1.48866891
19	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.46100824
20	Tryptophan metabolism_Homo sapiens_hsa00380	1.40917742
21	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.36338451
22	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.35809241
23	RNA degradation_Homo sapiens_hsa03018	1.35224402
24	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.35216590
25	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.34230954
26	Ether lipid metabolism_Homo sapiens_hsa00565	1.22882561
27	Sulfur metabolism_Homo sapiens_hsa00920	1.21214450
28	Caffeine metabolism_Homo sapiens_hsa00232	1.19654218
29	Chemical carcinogenesis_Homo sapiens_hsa05204	1.18800282
30	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.18155327
31	RNA polymerase_Homo sapiens_hsa03020	1.15385673
32	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.15063867
33	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.14958697
34	Taste transduction_Homo sapiens_hsa04742	1.13151368
35	Propanoate metabolism_Homo sapiens_hsa00640	1.12558298
36	T cell receptor signaling pathway_Homo sapiens_hsa04660	1.11469264
37	Nucleotide excision repair_Homo sapiens_hsa03420	1.11149260
38	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.10342149
39	Butanoate metabolism_Homo sapiens_hsa00650	1.09797538
40	Huntingtons disease_Homo sapiens_hsa05016	1.06978259
41	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	1.06550698
42	Olfactory transduction_Homo sapiens_hsa04740	1.06002465
43	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.04962609
44	Peroxisome_Homo sapiens_hsa04146	1.04503016
45	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.04377454
46	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	1.03898897
47	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.00042622
48	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.97764049
49	One carbon pool by folate_Homo sapiens_hsa00670	0.96348401
50	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.94602782
51	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.94357301
52	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.93384794
53	Serotonergic synapse_Homo sapiens_hsa04726	0.91385759
54	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.90153591
55	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.88997961
56	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.88519462
57	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.83755652
58	Allograft rejection_Homo sapiens_hsa05330	0.83119188
59	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.82487140
60	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.81829392
61	Nicotine addiction_Homo sapiens_hsa05033	0.81104491
62	Alzheimers disease_Homo sapiens_hsa05010	0.78380068
63	Type I diabetes mellitus_Homo sapiens_hsa04940	0.78291672
64	Morphine addiction_Homo sapiens_hsa05032	0.75847251
65	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.75642210
66	Non-homologous end-joining_Homo sapiens_hsa03450	0.75356623
67	Measles_Homo sapiens_hsa05162	0.74273566
68	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.74087897
69	Mineral absorption_Homo sapiens_hsa04978	0.73660383
70	Proteasome_Homo sapiens_hsa03050	0.72457121
71	Cardiac muscle contraction_Homo sapiens_hsa04260	0.72351597
72	Retinol metabolism_Homo sapiens_hsa00830	0.69664221
73	Insulin secretion_Homo sapiens_hsa04911	0.68100615
74	Graft-versus-host disease_Homo sapiens_hsa05332	0.67986310
75	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.66871089
76	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.64575709
77	Antigen processing and presentation_Homo sapiens_hsa04612	0.61530922
78	ABC transporters_Homo sapiens_hsa02010	0.58278624
79	RNA transport_Homo sapiens_hsa03013	0.56176652
80	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.55840028
81	Mismatch repair_Homo sapiens_hsa03430	0.54091726
82	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.51398316
83	p53 signaling pathway_Homo sapiens_hsa04115	0.50723047
84	Asthma_Homo sapiens_hsa05310	0.50269221
85	Amphetamine addiction_Homo sapiens_hsa05031	0.50201497
86	Calcium signaling pathway_Homo sapiens_hsa04020	0.48752647
87	Cocaine addiction_Homo sapiens_hsa05030	0.46749134
88	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.46428018
89	Purine metabolism_Homo sapiens_hsa00230	0.46028938
90	Glutamatergic synapse_Homo sapiens_hsa04724	0.45819534
91	Legionellosis_Homo sapiens_hsa05134	0.45434968
92	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.42618622
93	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.42108792
94	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.41456077
95	FoxO signaling pathway_Homo sapiens_hsa04068	0.40307930
96	Collecting duct acid secretion_Homo sapiens_hsa04966	0.38314570
97	Circadian entrainment_Homo sapiens_hsa04713	0.37816977
98	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.37013091
99	Ribosome_Homo sapiens_hsa03010	0.35866611
100	cAMP signaling pathway_Homo sapiens_hsa04024	0.34469186

ACRC

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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