ACRV1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a testis-specific, differentiation antigen, acrosomal vesicle protein 1, that arises within the acrosomal vesicle during spermatogenesis, and is associated with the acrosomal membranes and matrix of mature sperm. The acrosomal vesicle protein 1 may be involved in sperm-zona binding or penetration. Alternatively spliced transcript variants have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fusion of sperm to egg plasma membrane (GO:0007342)9.84253496
2cell wall macromolecule catabolic process (GO:0016998)9.40055678
3cell wall macromolecule metabolic process (GO:0044036)9.40055678
4multicellular organism reproduction (GO:0032504)9.18928259
5sperm motility (GO:0030317)9.12943870
6cilium or flagellum-dependent cell motility (GO:0001539)8.73137218
7acrosome reaction (GO:0007340)8.62607958
8sperm-egg recognition (GO:0035036)8.37318923
9acrosome assembly (GO:0001675)8.36104153
10cell-cell recognition (GO:0009988)7.50958257
11axonemal dynein complex assembly (GO:0070286)7.47496028
12plasma membrane fusion (GO:0045026)7.45076683
13motile cilium assembly (GO:0044458)7.43829830
14epithelial cilium movement (GO:0003351)7.33112611
15reproduction (GO:0000003)7.29436980
16binding of sperm to zona pellucida (GO:0007339)7.24690354
17spermatid development (GO:0007286)6.39684216
18cilium movement (GO:0003341)6.03194605
19single fertilization (GO:0007338)6.02145605
20epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.87699428
21regulation of cilium movement (GO:0003352)5.76410508
22piRNA metabolic process (GO:0034587)5.68020052
23microtubule depolymerization (GO:0007019)5.64867029
24male meiosis (GO:0007140)5.59002190
25chromatin remodeling at centromere (GO:0031055)5.37102797
26CENP-A containing nucleosome assembly (GO:0034080)5.23948300
27sperm capacitation (GO:0048240)5.08558268
28DNA replication checkpoint (GO:0000076)5.04539865
29fertilization (GO:0009566)4.69490370
30histone exchange (GO:0043486)4.63036352
31synaptonemal complex organization (GO:0070193)4.62883025
32centriole assembly (GO:0098534)4.59742646
33synaptonemal complex assembly (GO:0007130)4.56321121
34DNA methylation involved in gamete generation (GO:0043046)4.47106084
35DNA replication-independent nucleosome organization (GO:0034724)4.33957746
36DNA replication-independent nucleosome assembly (GO:0006336)4.33957746
37spermatogenesis (GO:0007283)4.31643529
38male gamete generation (GO:0048232)4.30854288
39replication fork processing (GO:0031297)4.21881328
40kinetochore organization (GO:0051383)4.02091972
41gamete generation (GO:0007276)4.01385329
42mitotic sister chromatid segregation (GO:0000070)4.00838744
43chromosome organization involved in meiosis (GO:0070192)3.98965152
44regulation of DNA endoreduplication (GO:0032875)3.98174812
45organic cation transport (GO:0015695)3.91480972
46sister chromatid segregation (GO:0000819)3.86791000
47ventricular system development (GO:0021591)3.82460103
48negative regulation of DNA-dependent DNA replication (GO:2000104)3.82395830
49sequestering of actin monomers (GO:0042989)3.82250340
50male meiosis I (GO:0007141)3.81112752
51establishment of protein localization to mitochondrial membrane (GO:0090151)3.80076886
52kinetochore assembly (GO:0051382)3.79121366
53intraciliary transport (GO:0042073)3.71739089
54telomere maintenance via semi-conservative replication (GO:0032201)3.68981898
55calcium ion-dependent exocytosis (GO:0017156)3.68904397
56cellular process involved in reproduction in multicellular organism (GO:0022412)3.65594284
57resolution of meiotic recombination intermediates (GO:0000712)3.65162010
58protein localization to kinetochore (GO:0034501)3.63973577
59germ cell development (GO:0007281)3.62552846
60centriole replication (GO:0007099)3.60281034
61cell recognition (GO:0008037)3.58493254
62DNA catabolic process, exonucleolytic (GO:0000738)3.54911303
63DNA strand elongation involved in DNA replication (GO:0006271)3.54393492
64maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.53149676
65proteasome assembly (GO:0043248)3.52885061
66synapsis (GO:0007129)3.50055048
67daunorubicin metabolic process (GO:0044597)3.50047996
68polyketide metabolic process (GO:0030638)3.50047996
69doxorubicin metabolic process (GO:0044598)3.50047996
70regulation of nuclear cell cycle DNA replication (GO:0033262)3.48481620
71regulation of centriole replication (GO:0046599)3.43281731
72postreplication repair (GO:0006301)3.40866625
73mitotic recombination (GO:0006312)3.38142462
74meiotic nuclear division (GO:0007126)3.37845112
75protein localization to cilium (GO:0061512)3.32780366
76microtubule severing (GO:0051013)3.32199192
77cilium organization (GO:0044782)3.30751769
78DNA strand elongation (GO:0022616)3.30475537
79cilium assembly (GO:0042384)3.28542635
80DNA strand renaturation (GO:0000733)3.27647445
81telomere maintenance via recombination (GO:0000722)3.27447393
82chaperone-mediated protein transport (GO:0072321)3.24832849
83DNA replication-dependent nucleosome assembly (GO:0006335)3.22672912
84DNA replication-dependent nucleosome organization (GO:0034723)3.22672912
85recombinational repair (GO:0000725)3.19222946
86translesion synthesis (GO:0019985)3.17945285
87regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.16755004
88somatic hypermutation of immunoglobulin genes (GO:0016446)3.16028925
89somatic diversification of immune receptors via somatic mutation (GO:0002566)3.16028925
90double-strand break repair via homologous recombination (GO:0000724)3.14612859
91multicellular organismal reproductive process (GO:0048609)3.11990268
92regulation of mitotic spindle checkpoint (GO:1903504)3.11922884
93regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.11922884
94protein K11-linked deubiquitination (GO:0035871)3.11302496
95negative regulation of DNA recombination (GO:0045910)3.10964399
96single strand break repair (GO:0000012)3.10901755
97respiratory chain complex IV assembly (GO:0008535)3.08415805
98spermatid nucleus differentiation (GO:0007289)3.05037010
99spindle checkpoint (GO:0031577)3.03942107
100histone H2A acetylation (GO:0043968)3.03805880
101mitotic metaphase plate congression (GO:0007080)3.03760012
102ATP-dependent chromatin remodeling (GO:0043044)3.02132605
103cullin deneddylation (GO:0010388)3.01252183
104DNA topological change (GO:0006265)3.00904810
105superoxide anion generation (GO:0042554)3.00510692
106rRNA modification (GO:0000154)3.00313662
107transcription elongation from RNA polymerase III promoter (GO:0006385)2.98524473
108termination of RNA polymerase III transcription (GO:0006386)2.98524473
109metaphase plate congression (GO:0051310)2.97659460
110microtubule polymerization or depolymerization (GO:0031109)2.96111443
111regulation of spindle checkpoint (GO:0090231)2.95863525
112nucleotide-excision repair, DNA gap filling (GO:0006297)2.95818104
113negative regulation of transcription regulatory region DNA binding (GO:2000678)2.94456389
114meiosis I (GO:0007127)2.93526639
115regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.93126405
116response to pheromone (GO:0019236)2.91221821
117DNA ligation (GO:0006266)2.89759447
118negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.88591158
119monoubiquitinated protein deubiquitination (GO:0035520)2.88580324
120energy homeostasis (GO:0097009)2.87367283
121telomere maintenance via telomere lengthening (GO:0010833)2.86610974
122protein polyglutamylation (GO:0018095)2.86598719
123meiotic cell cycle (GO:0051321)2.86252629
124mitotic spindle checkpoint (GO:0071174)2.85399159
125regulation of helicase activity (GO:0051095)2.83365404
126negative regulation of chromosome segregation (GO:0051985)2.83331663
127cytochrome complex assembly (GO:0017004)2.82843212
128negative regulation of mitotic sister chromatid separation (GO:2000816)2.81930982
129negative regulation of sister chromatid segregation (GO:0033046)2.81930982
130negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.81930982
131negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.81930982
132negative regulation of mitotic sister chromatid segregation (GO:0033048)2.81930982
133regulation of centrosome cycle (GO:0046605)2.81016962
134anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.80484806
135centrosome organization (GO:0051297)2.76862553
136positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.74048240
137mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.74044642
138cellular component assembly involved in morphogenesis (GO:0010927)2.73367641
139chromosome segregation (GO:0007059)2.73314114
140protein neddylation (GO:0045116)2.72823668
141attachment of spindle microtubules to kinetochore (GO:0008608)2.68198323
142otic vesicle formation (GO:0030916)2.66929815
143protein deneddylation (GO:0000338)2.66762478
144reciprocal DNA recombination (GO:0035825)2.64605589
145reciprocal meiotic recombination (GO:0007131)2.64605589
146protein complex biogenesis (GO:0070271)2.64447253
147negative regulation of ligase activity (GO:0051352)2.62708419
148negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.62708419
149non-recombinational repair (GO:0000726)2.62138104
150double-strand break repair via nonhomologous end joining (GO:0006303)2.62138104
151axoneme assembly (GO:0035082)2.61834887
152rRNA methylation (GO:0031167)2.60992563
153DNA-dependent DNA replication (GO:0006261)2.60970345
154spindle assembly checkpoint (GO:0071173)2.60831228
155DNA recombination (GO:0006310)2.60818914
156mitotic spindle assembly checkpoint (GO:0007094)2.60605075
157negative regulation of inclusion body assembly (GO:0090084)2.60467604
158protein K6-linked ubiquitination (GO:0085020)2.59496322
159nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.58352473
160regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.58081385
161regulation of mitotic metaphase/anaphase transition (GO:0030071)2.58081385
162chromatin assembly or disassembly (GO:0006333)2.57596369
163regulation of mitotic sister chromatid segregation (GO:0033047)2.56691556
164* multicellular organismal development (GO:0007275)2.55894484
165glycerol ether metabolic process (GO:0006662)2.52818346
166meiotic chromosome segregation (GO:0045132)2.52159888
167meiotic cell cycle process (GO:1903046)2.52049955
168regulation of microtubule-based movement (GO:0060632)2.49823829
169positive regulation of cellular amide metabolic process (GO:0034250)2.49484758
170cellular response to gamma radiation (GO:0071480)2.49367201
171regulation of activation of Janus kinase activity (GO:0010533)2.42213916
172nucleoside diphosphate catabolic process (GO:0009134)2.39838115
173DNA deamination (GO:0045006)2.39034585
174DNA double-strand break processing (GO:0000729)2.39032059
175regulation of inclusion body assembly (GO:0090083)2.39032052
176detection of molecule of bacterial origin (GO:0032490)2.38987891
177negative regulation of mast cell activation (GO:0033004)2.38753929
178positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)2.38581158
179negative regulation of skeletal muscle tissue development (GO:0048642)2.38274374
180ether metabolic process (GO:0018904)2.37224444
181urinary tract smooth muscle contraction (GO:0014848)2.36913591
182RNA destabilization (GO:0050779)2.36859667
183GTP biosynthetic process (GO:0006183)2.35332541
184sulfate transmembrane transport (GO:1902358)2.32472114
185sulfate transport (GO:0008272)2.32011269
186cilium morphogenesis (GO:0060271)2.30855138
187auditory receptor cell stereocilium organization (GO:0060088)2.29765289
188left/right pattern formation (GO:0060972)2.28644778
189female gonad development (GO:0008585)2.27517550
190nucleoside diphosphate phosphorylation (GO:0006165)2.19907738
191left/right axis specification (GO:0070986)2.14863145

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.13398520
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse5.33800929
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.63195529
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.95824114
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.95632244
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.60091126
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.24253854
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.16178410
9FLI1_27457419_Chip-Seq_LIVER_Mouse3.14807070
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.14664544
11PCGF2_27294783_Chip-Seq_ESCs_Mouse3.10889397
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.98781578
13GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.86139857
14SALL1_21062744_ChIP-ChIP_HESCs_Human2.79711609
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.77181188
16ZFP57_27257070_Chip-Seq_ESCs_Mouse2.67527420
17SUZ12_27294783_Chip-Seq_NPCs_Mouse2.43252663
18PCGF2_27294783_Chip-Seq_NPCs_Mouse2.41875498
19HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.41679684
20NFE2_27457419_Chip-Seq_LIVER_Mouse2.39928340
21RBPJ_22232070_ChIP-Seq_NCS_Mouse2.36393003
22HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.36163360
23VDR_22108803_ChIP-Seq_LS180_Human2.33928299
24EZH2_22144423_ChIP-Seq_EOC_Human2.29311955
25CBX2_27304074_Chip-Seq_ESCs_Mouse2.23255889
26ELK1_19687146_ChIP-ChIP_HELA_Human2.21428459
27CREB1_15753290_ChIP-ChIP_HEK293T_Human2.18719215
28ZNF274_21170338_ChIP-Seq_K562_Hela2.17636508
29JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.16358830
30GBX2_23144817_ChIP-Seq_PC3_Human2.14846354
31CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.08413496
32CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.06216411
33MYC_18555785_ChIP-Seq_MESCs_Mouse2.03204951
34EZH2_27294783_Chip-Seq_NPCs_Mouse2.02093587
35TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse2.00819118
36NANOG_18555785_Chip-Seq_ESCs_Mouse1.97963249
37EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.97004197
38ETS1_20019798_ChIP-Seq_JURKAT_Human1.95416346
39BP1_19119308_ChIP-ChIP_Hs578T_Human1.94582153
40TAF15_26573619_Chip-Seq_HEK293_Human1.93978935
41MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.92788479
42POU5F1_16153702_ChIP-ChIP_HESCs_Human1.92608020
43P53_22387025_ChIP-Seq_ESCs_Mouse1.91638695
44SUZ12_18555785_Chip-Seq_ESCs_Mouse1.90507139
45STAT3_18555785_Chip-Seq_ESCs_Mouse1.89875815
46BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.85834717
47EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.83048467
48RNF2_27304074_Chip-Seq_NSC_Mouse1.81817804
49OCT4_18555785_Chip-Seq_ESCs_Mouse1.80771323
50CMYC_18555785_Chip-Seq_ESCs_Mouse1.79036810
51E2F1_18555785_Chip-Seq_ESCs_Mouse1.78773598
52AR_21909140_ChIP-Seq_LNCAP_Human1.77807967
53PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.77574647
54P300_18555785_Chip-Seq_ESCs_Mouse1.76201389
55NMYC_18555785_Chip-Seq_ESCs_Mouse1.75839181
56MYC_18940864_ChIP-ChIP_HL60_Human1.72104684
57RUNX1_27457419_Chip-Seq_LIVER_Mouse1.71328217
58TAL1_26923725_Chip-Seq_HPCs_Mouse1.70895074
59KAP1_22055183_ChIP-Seq_ESCs_Mouse1.69922491
60KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.69784944
61KLF4_18555785_Chip-Seq_ESCs_Mouse1.69566420
62E2F1_21310950_ChIP-Seq_MCF-7_Human1.66408345
63POU3F2_20337985_ChIP-ChIP_501MEL_Human1.66348358
64ESRRB_18555785_Chip-Seq_ESCs_Mouse1.64063842
65SOX2_18555785_Chip-Seq_ESCs_Mouse1.63812448
66VDR_23849224_ChIP-Seq_CD4+_Human1.63601076
67CRX_20693478_ChIP-Seq_RETINA_Mouse1.63478861
68FOXP3_21729870_ChIP-Seq_TREG_Human1.62910716
69PU1_27457419_Chip-Seq_LIVER_Mouse1.61199945
70IGF1R_20145208_ChIP-Seq_DFB_Human1.61168141
71ZFX_18555785_Chip-Seq_ESCs_Mouse1.59722705
72CTCF_18555785_Chip-Seq_ESCs_Mouse1.57005078
73RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.56618018
74EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.55660323
75FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.54368635
76MYC_19030024_ChIP-ChIP_MESCs_Mouse1.54292462
77CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.51543982
78OCT4_21477851_ChIP-Seq_ESCs_Mouse1.51160536
79SMAD1_18555785_Chip-Seq_ESCs_Mouse1.50742734
80BMI1_23680149_ChIP-Seq_NPCS_Mouse1.49763965
81KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.48272237
82NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.47182220
83STAT1_17558387_ChIP-Seq_HELA_Human1.45261980
84CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.45208017
85PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.45145109
86MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.44633124
87MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.43941619
88* KDM2B_26808549_Chip-Seq_REH_Human1.42855324
89PADI4_21655091_ChIP-ChIP_MCF-7_Human1.41604260
90YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.41339895
91MYC_18358816_ChIP-ChIP_MESCs_Mouse1.39793531
92HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.39091044
93TP63_19390658_ChIP-ChIP_HaCaT_Human1.38097264
94TTF2_22483619_ChIP-Seq_HELA_Human1.37916726
95ER_23166858_ChIP-Seq_MCF-7_Human1.34745164
96P300_19829295_ChIP-Seq_ESCs_Human1.34706752
97CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.34321405
98SOX2_16153702_ChIP-ChIP_HESCs_Human1.34263175
99SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.33876771
100CTBP2_25329375_ChIP-Seq_LNCAP_Human1.33254741
101MYC_19079543_ChIP-ChIP_MESCs_Mouse1.32918116
102GABP_19822575_ChIP-Seq_HepG2_Human1.32913732
103FUS_26573619_Chip-Seq_HEK293_Human1.32464175
104NANOG_16153702_ChIP-ChIP_HESCs_Human1.30918851
105IRF8_21731497_ChIP-ChIP_J774_Mouse1.27756199
106SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.26963990
107POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.23282615
108TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23282615
109CTBP1_25329375_ChIP-Seq_LNCAP_Human1.22707423
110IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.22612722
111EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.22408238
112POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.20154493
113MYCN_18555785_ChIP-Seq_MESCs_Mouse1.18759656
114CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.16878628
115NOTCH1_21737748_ChIP-Seq_TLL_Human1.16554411
116DCP1A_22483619_ChIP-Seq_HELA_Human1.16526033
117POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.16366970
118CBP_20019798_ChIP-Seq_JUKART_Human1.14652098
119IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.14652098
120E2F1_18555785_ChIP-Seq_MESCs_Mouse1.13742427
121SRF_21415370_ChIP-Seq_HL-1_Mouse1.12487832
122TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.11464452
123GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.11224151
124THAP11_20581084_ChIP-Seq_MESCs_Mouse1.09448645
125NELFA_20434984_ChIP-Seq_ESCs_Mouse1.09242254
126MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.07954028
127NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.07737663
128ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.07236451
129UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.07007451
130GF1_26923725_Chip-Seq_HPCs_Mouse1.05763358
131GATA1_26923725_Chip-Seq_HPCs_Mouse1.05289638
132SOX2_18555785_ChIP-Seq_MESCs_Mouse1.04396117
133GATA3_21867929_ChIP-Seq_TH1_Mouse1.04324258
134MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01409216
135SMAD4_21799915_ChIP-Seq_A2780_Human1.01405357
136ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.01270016
137TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98675897
138ETV1_20927104_ChIP-Seq_GIST48_Human0.97670359
139XRN2_22483619_ChIP-Seq_HELA_Human0.97375609
140SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.96993608
141YY1_21170310_ChIP-Seq_MESCs_Mouse0.96332131
142TP53_22573176_ChIP-Seq_HFKS_Human0.95725446
143PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.95438338
144TCF4_23295773_ChIP-Seq_U87_Human0.95246719
145SOX9_26525672_Chip-Seq_HEART_Mouse0.94969461
146HOXB4_20404135_ChIP-ChIP_EML_Mouse0.94453145
147FLI1_21867929_ChIP-Seq_TH2_Mouse0.94417415
148E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.94352426
149GF1B_26923725_Chip-Seq_HPCs_Mouse0.94334354
150PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94321465
151* GATA3_21867929_ChIP-Seq_CD8_Mouse0.93875245
152AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.93107449
153NFYB_21822215_ChIP-Seq_K562_Human0.92622153
154IRF1_19129219_ChIP-ChIP_H3396_Human0.91470341
155KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.90702115
156AR_25329375_ChIP-Seq_VCAP_Human0.90395134
157PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.89064482
158IRF8_22096565_ChIP-ChIP_GC-B_Human0.87093094
159WDR5_24793694_ChIP-Seq_LNCAP_Human0.86922893
160REST_21632747_ChIP-Seq_MESCs_Mouse0.86805294
161PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.86639936
162PHF8_20622853_ChIP-Seq_HELA_Human0.86457491
163* SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.85983568
164LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.85743938
165EWS_26573619_Chip-Seq_HEK293_Human0.85721772
166Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.85322553
167NANOG_19829295_ChIP-Seq_ESCs_Human0.83438522
168SOX2_19829295_ChIP-Seq_ESCs_Human0.83438522
169FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.82445557
170TOP2B_26459242_ChIP-Seq_MCF-7_Human0.82321718
171BCAT_22108803_ChIP-Seq_LS180_Human0.81925468
172ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.81670875
173KLF5_20875108_ChIP-Seq_MESCs_Mouse0.80497197
174NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.78497120
175JUN_21703547_ChIP-Seq_K562_Human0.77787863

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization9.30645231
2MP0003698_abnormal_male_reproductive3.82860998
3MP0008877_abnormal_DNA_methylation3.67258041
4MP0001929_abnormal_gametogenesis3.44219090
5MP0003880_abnormal_central_pattern3.10594065
6MP0002210_abnormal_sex_determination2.62597485
7MP0006292_abnormal_olfactory_placode2.51591102
8MP0003890_abnormal_embryonic-extraembry2.45789871
9MP0004957_abnormal_blastocyst_morpholog2.44657190
10MP0002132_abnormal_respiratory_system2.44100590
11MP0003693_abnormal_embryo_hatching2.43840720
12MP0001188_hyperpigmentation2.32943660
13MP0008058_abnormal_DNA_repair2.28955403
14MP0000566_synostosis2.21483114
15MP0009697_abnormal_copulation2.21336628
16MP0003123_paternal_imprinting2.16820119
17MP0005645_abnormal_hypothalamus_physiol2.16373110
18MP0001984_abnormal_olfaction2.05795252
19MP0003121_genomic_imprinting1.96302363
20MP0003077_abnormal_cell_cycle1.94644292
21MP0001145_abnormal_male_reproductive1.93940498
22MP0010030_abnormal_orbit_morphology1.93299407
23MP0002161_abnormal_fertility/fecundity1.92169502
24MP0008057_abnormal_DNA_replication1.90281343
25MP0000778_abnormal_nervous_system1.89606273
26MP0002234_abnormal_pharynx_morphology1.88371493
27MP0008932_abnormal_embryonic_tissue1.84616267
28MP0001835_abnormal_antigen_presentation1.84315246
29MP0003718_maternal_effect1.81465813
30MP0000653_abnormal_sex_gland1.78802025
31MP0005646_abnormal_pituitary_gland1.75286418
32MP0002277_abnormal_respiratory_mucosa1.68280610
33MP0002148_abnormal_hypersensitivity_rea1.66126170
34MP0002653_abnormal_ependyma_morphology1.63371949
35MP0000015_abnormal_ear_pigmentation1.63045368
36MP0009785_altered_susceptibility_to1.61086189
37MP0002160_abnormal_reproductive_system1.57202992
38MP0002638_abnormal_pupillary_reflex1.53224563
39MP0008995_early_reproductive_senescence1.51387314
40MP0003786_premature_aging1.50202567
41MP0001986_abnormal_taste_sensitivity1.49196847
42MP0004782_abnormal_surfactant_physiolog1.48817702
43MP0008260_abnormal_autophagy1.47754575
44MP0003122_maternal_imprinting1.45020719
45MP0010094_abnormal_chromosome_stability1.44290853
46MP0003941_abnormal_skin_development1.40796297
47MP0005671_abnormal_response_to1.40157535
48MP0004133_heterotaxia1.40096516
49MP0009379_abnormal_foot_pigmentation1.39217898
50MP0005171_absent_coat_pigmentation1.37217116
51MP0003567_abnormal_fetal_cardiomyocyte1.37051872
52MP0001346_abnormal_lacrimal_gland1.33844349
53MP0003136_yellow_coat_color1.32521580
54MP0005670_abnormal_white_adipose1.31930578
55MP0002876_abnormal_thyroid_physiology1.31409238
56MP0005409_darkened_coat_color1.29316987
57MP0003938_abnormal_ear_development1.28607725
58MP0002102_abnormal_ear_morphology1.27001488
59MP0002233_abnormal_nose_morphology1.26578747
60MP0002751_abnormal_autonomic_nervous1.23162191
61MP0001286_abnormal_eye_development1.22599860
62MP0005389_reproductive_system_phenotype1.22160392
63MP0010386_abnormal_urinary_bladder1.21027825
64MP0005647_abnormal_sex_gland1.19308887
65MP0002009_preneoplasia1.17382854
66MP0008007_abnormal_cellular_replicative1.15266110
67MP0006072_abnormal_retinal_apoptosis1.13634542
68MP0008789_abnormal_olfactory_epithelium1.12653784
69MP0000049_abnormal_middle_ear1.12235772
70MP0001485_abnormal_pinna_reflex1.10340068
71MP0002272_abnormal_nervous_system1.09558778
72MP0003195_calcinosis1.09291159
73MP0003315_abnormal_perineum_morphology1.09211121
74MP0001119_abnormal_female_reproductive1.08638353
75MP0003787_abnormal_imprinting1.07811422
76MP0003937_abnormal_limbs/digits/tail_de1.07605093
77MP0003724_increased_susceptibility_to1.07543262
78MP0003119_abnormal_digestive_system1.05663559
79MP0003755_abnormal_palate_morphology1.05321968
80MP0005075_abnormal_melanosome_morpholog1.05168013
81MP0009046_muscle_twitch1.05063146
82MP0005174_abnormal_tail_pigmentation1.01524520
83MP0000647_abnormal_sebaceous_gland1.01199269
84MP0003861_abnormal_nervous_system1.00772519
85MP0002184_abnormal_innervation1.00621595
86MP0003878_abnormal_ear_physiology0.97007303
87MP0005377_hearing/vestibular/ear_phenot0.97007303
88MP0002419_abnormal_innate_immunity0.96765846
89MP0006276_abnormal_autonomic_nervous0.96395173
90MP0003646_muscle_fatigue0.94258351
91MP0000516_abnormal_urinary_system0.93272667
92MP0005367_renal/urinary_system_phenotyp0.93272667
93MP0002697_abnormal_eye_size0.93066544
94MP0000678_abnormal_parathyroid_gland0.92486645
95MP0003111_abnormal_nucleus_morphology0.89956370
96MP0002085_abnormal_embryonic_tissue0.88168421
97MP0001486_abnormal_startle_reflex0.87000455
98MP0005084_abnormal_gallbladder_morpholo0.86968474
99MP0002752_abnormal_somatic_nervous0.86865055
100MP0003763_abnormal_thymus_physiology0.86618476
101MP0005551_abnormal_eye_electrophysiolog0.86299990
102MP0001968_abnormal_touch/_nociception0.86253173
103MP0005000_abnormal_immune_tolerance0.86182312
104MP0003137_abnormal_impulse_conducting0.85517668
105MP0002095_abnormal_skin_pigmentation0.85271080
106MP0004142_abnormal_muscle_tone0.84693960
107MP0005187_abnormal_penis_morphology0.84636421
108MP0000372_irregular_coat_pigmentation0.83816190
109MP0005025_abnormal_response_to0.83680847
110MP0005394_taste/olfaction_phenotype0.83268072
111MP0005499_abnormal_olfactory_system0.83268072
112MP0002163_abnormal_gland_morphology0.83181682
113MP0002557_abnormal_social/conspecific_i0.83122376
114MP0000631_abnormal_neuroendocrine_gland0.82625983
115MP0002736_abnormal_nociception_after0.82613724
116MP0001697_abnormal_embryo_size0.81433459
117MP0001764_abnormal_homeostasis0.81319932
118MP0009764_decreased_sensitivity_to0.80767465
119MP0002938_white_spotting0.80734705
120MP0000955_abnormal_spinal_cord0.80636364
121MP0005253_abnormal_eye_physiology0.79268974
122MP0002723_abnormal_immune_serum0.78128029
123MP0004742_abnormal_vestibular_system0.77765636
124MP0002084_abnormal_developmental_patter0.77696110
125MP0001790_abnormal_immune_system0.77472201
126MP0005387_immune_system_phenotype0.77472201
127MP0005379_endocrine/exocrine_gland_phen0.77435104
128MP0002837_dystrophic_cardiac_calcinosis0.77095344
129MP0001919_abnormal_reproductive_system0.77067308
130MP0002452_abnormal_antigen_presenting0.74756777
131MP0004381_abnormal_hair_follicle0.74079242
132MP0002152_abnormal_brain_morphology0.73970701
133MP0000681_abnormal_thyroid_gland0.73828322
134MP0002111_abnormal_tail_morphology0.73490052
135MP0005195_abnormal_posterior_eye0.73458913
136MP0008872_abnormal_physiological_respon0.72129609
137MP0008004_abnormal_stomach_pH0.71407581
138MP0002928_abnormal_bile_duct0.70662159
139MP0001819_abnormal_immune_cell0.70514615
140MP0002420_abnormal_adaptive_immunity0.70090302
141MP0001529_abnormal_vocalization0.70038135
142MP0009745_abnormal_behavioral_response0.70032900
143MP0000428_abnormal_craniofacial_morphol0.69966264
144MP0001324_abnormal_eye_pigmentation0.69664088
145MP0002572_abnormal_emotion/affect_behav0.67839335
146MP0002405_respiratory_system_inflammati0.67399363
147MP0002396_abnormal_hematopoietic_system0.67204189
148MP0000026_abnormal_inner_ear0.67060395
149MP0005310_abnormal_salivary_gland0.66256155
150MP0001800_abnormal_humoral_immune0.65248273
151MP0001293_anophthalmia0.62870097
152MP0003950_abnormal_plasma_membrane0.60521614
153MP0001502_abnormal_circadian_rhythm0.59394330
154MP0000427_abnormal_hair_cycle0.58391199
155MP0003943_abnormal_hepatobiliary_system0.58153236
156MP0002735_abnormal_chemical_nociception0.57738581
157MP0005503_abnormal_tendon_morphology0.56528519

Predicted human phenotypes

RankGene SetZ-score
1Absent/shortened dynein arms (HP:0200106)9.40891898
2Dynein arm defect of respiratory motile cilia (HP:0012255)9.40891898
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)9.10611461
4Abnormal respiratory epithelium morphology (HP:0012253)6.51429623
5Abnormal respiratory motile cilium morphology (HP:0005938)6.51429623
6Abnormal respiratory motile cilium physiology (HP:0012261)6.50797826
7Abnormal ciliary motility (HP:0012262)5.85475738
8Rhinitis (HP:0012384)4.88953543
9Abnormality of the labia minora (HP:0012880)4.20431389
10Chronic bronchitis (HP:0004469)3.83578143
11Nephronophthisis (HP:0000090)3.74119183
12Infertility (HP:0000789)3.55987015
13Chromosomal breakage induced by crosslinking agents (HP:0003221)3.53088436
14Retrobulbar optic neuritis (HP:0100654)3.39657030
15Optic neuritis (HP:0100653)3.39657030
16Medial flaring of the eyebrow (HP:0010747)3.20067569
17Chromsome breakage (HP:0040012)3.18657559
18Abnormal spermatogenesis (HP:0008669)3.15015178
19Abnormality of the renal medulla (HP:0100957)3.10657717
20Bronchiectasis (HP:0002110)3.02281459
21Colon cancer (HP:0003003)2.97779858
22Molar tooth sign on MRI (HP:0002419)2.95500317
23Abnormality of midbrain morphology (HP:0002418)2.95500317
24True hermaphroditism (HP:0010459)2.93184193
25Pancreatic fibrosis (HP:0100732)2.86513427
26Recurrent sinusitis (HP:0011108)2.83451895
27Tubulointerstitial nephritis (HP:0001970)2.80044125
28Duodenal stenosis (HP:0100867)2.76362747
29Small intestinal stenosis (HP:0012848)2.76362747
30Acute necrotizing encephalopathy (HP:0006965)2.71626321
31Nasal polyposis (HP:0100582)2.71588530
32Abnormality of the duodenum (HP:0002246)2.71287836
33Absent septum pellucidum (HP:0001331)2.69793684
34Intestinal atresia (HP:0011100)2.64287979
35Azoospermia (HP:0000027)2.59452948
36Bronchitis (HP:0012387)2.58121444
37Orchitis (HP:0100796)2.56742545
38Acute encephalopathy (HP:0006846)2.56252547
39Postaxial foot polydactyly (HP:0001830)2.55327944
40Oligodactyly (hands) (HP:0001180)2.50039608
41Reticulocytopenia (HP:0001896)2.47680626
42Horseshoe kidney (HP:0000085)2.41670384
43Abnormal lung lobation (HP:0002101)2.41431401
44Chronic hepatic failure (HP:0100626)2.39299807
45Increased CSF lactate (HP:0002490)2.39066006
46Triphalangeal thumb (HP:0001199)2.38909500
47Gonadotropin excess (HP:0000837)2.36699243
48Mitochondrial inheritance (HP:0001427)2.34850998
49Anophthalmia (HP:0000528)2.33832550
50Optic nerve hypoplasia (HP:0000609)2.33187654
51Sloping forehead (HP:0000340)2.32440663
52Progressive macrocephaly (HP:0004481)2.31401403
53Abnormality of the carotid arteries (HP:0005344)2.31000779
54Supernumerary spleens (HP:0009799)2.30219382
55Neoplasm of the adrenal cortex (HP:0100641)2.29737352
56Hepatocellular necrosis (HP:0001404)2.29449807
57Abnormality of the septum pellucidum (HP:0007375)2.28827966
58Abnormal mitochondria in muscle tissue (HP:0008316)2.26493797
59Congenital primary aphakia (HP:0007707)2.26408228
60Congenital hepatic fibrosis (HP:0002612)2.25881551
61Absent radius (HP:0003974)2.25741829
62Nephrogenic diabetes insipidus (HP:0009806)2.25238353
63Aplasia/Hypoplasia of the uvula (HP:0010293)2.24569165
64Aplasia/Hypoplasia of the sacrum (HP:0008517)2.24181565
65Decreased central vision (HP:0007663)2.23649874
66Pancreatic cysts (HP:0001737)2.22082853
67Increased hepatocellular lipid droplets (HP:0006565)2.21651592
68Prostate neoplasm (HP:0100787)2.21481356
69Abnormality of the preputium (HP:0100587)2.20839385
70Abnormality of the renal cortex (HP:0011035)2.19324755
71Gait imbalance (HP:0002141)2.17475470
72Abnormality of chromosome stability (HP:0003220)2.16327361
73Absent forearm bone (HP:0003953)2.16283699
74Aplasia involving forearm bones (HP:0009822)2.16283699
75Ependymoma (HP:0002888)2.15099002
76Nephroblastoma (Wilms tumor) (HP:0002667)2.15077516
77Growth hormone deficiency (HP:0000824)2.12299869
78Impulsivity (HP:0100710)2.12261742
79Hepatic necrosis (HP:0002605)2.11071122
80Congenital sensorineural hearing impairment (HP:0008527)2.09107365
81Facial cleft (HP:0002006)2.09063386
82Median cleft lip (HP:0000161)2.07259918
83Myositis (HP:0100614)2.06058089
84Sclerocornea (HP:0000647)2.05721698
85Anencephaly (HP:0002323)2.05311297
86Birth length less than 3rd percentile (HP:0003561)2.04269912
87Meckel diverticulum (HP:0002245)2.03929687
88Agnosia (HP:0010524)2.03728736
89Myelodysplasia (HP:0002863)2.03142814
90Volvulus (HP:0002580)2.01116694
91Exertional dyspnea (HP:0002875)1.99533023
92Cerebral edema (HP:0002181)1.99459801
93Lipid accumulation in hepatocytes (HP:0006561)1.99417911
94Abnormality of the ileum (HP:0001549)1.98228239
95Type 2 muscle fiber atrophy (HP:0003554)1.97534786
96Pendular nystagmus (HP:0012043)1.96794683
97Recurrent otitis media (HP:0000403)1.96737136
98Dyschromatopsia (HP:0007641)1.95756420
99Absent thumb (HP:0009777)1.95566571
100Ectopic kidney (HP:0000086)1.94921454
101Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.94796879
102Aplasia/Hypoplasia of the tongue (HP:0010295)1.94248422
103Tubulointerstitial abnormality (HP:0001969)1.93865954
104Aplasia/Hypoplasia of the fovea (HP:0008060)1.92940200
105Hypoplasia of the fovea (HP:0007750)1.92940200
106Aqueductal stenosis (HP:0002410)1.92273022
107Bifid tongue (HP:0010297)1.92121400
108Renal dysplasia (HP:0000110)1.91721882
109Maternal diabetes (HP:0009800)1.91584557
110Abnormality of the nasal mucosa (HP:0000433)1.91432655
111Clubbing of toes (HP:0100760)1.88886752
112Postaxial hand polydactyly (HP:0001162)1.87626539
113Aplasia/Hypoplasia of the lens (HP:0008063)1.85855806
114Keratoconjunctivitis sicca (HP:0001097)1.85847703
115Hypoplastic pelvis (HP:0008839)1.85754136
116Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.85608944
117Abnormal biliary tract physiology (HP:0012439)1.84948390
118Bile duct proliferation (HP:0001408)1.84948390
119Hyperglycinemia (HP:0002154)1.83993248
120Dandy-Walker malformation (HP:0001305)1.83839758
121Esophageal atresia (HP:0002032)1.83159949
122Poor coordination (HP:0002370)1.83066006
123Absent eyebrow (HP:0002223)1.81879875
124Preaxial hand polydactyly (HP:0001177)1.81589121
125Duplicated collecting system (HP:0000081)1.80982459
126Abnormality of the renal collecting system (HP:0004742)1.79962498
127Oligodactyly (HP:0012165)1.76651819
128Hypoplasia of the capital femoral epiphysis (HP:0003090)1.75848494
129Keratoconjunctivitis (HP:0001096)1.75511339
130Lissencephaly (HP:0001339)1.75364185
131Abnormality of abdominal situs (HP:0011620)1.75332112
132Abdominal situs inversus (HP:0003363)1.75332112
133Tubular atrophy (HP:0000092)1.75242663
134Aganglionic megacolon (HP:0002251)1.75058908
135Increased serum lactate (HP:0002151)1.74628308
136Recurrent bronchitis (HP:0002837)1.74483646
137Male infertility (HP:0003251)1.74419637
138Abnormality of renal resorption (HP:0011038)1.74168880
139Limb dystonia (HP:0002451)1.73961004
140Type I transferrin isoform profile (HP:0003642)1.73583440
141Abnormal rod and cone electroretinograms (HP:0008323)1.73525083
142Absent rod-and cone-mediated responses on ERG (HP:0007688)1.73349522
143Severe visual impairment (HP:0001141)1.73331112
144Rib fusion (HP:0000902)1.72515188
145Astigmatism (HP:0000483)1.72344626
146Septo-optic dysplasia (HP:0100842)1.72286189
147Oligohydramnios (HP:0001562)1.72027385
148Holoprosencephaly (HP:0001360)1.71601670
149Alveolar cell carcinoma (HP:0006519)1.70073449
150Progressive inability to walk (HP:0002505)1.70018933
151Small hand (HP:0200055)1.69519405
152Genital tract atresia (HP:0001827)1.68804183
153Patellar aplasia (HP:0006443)1.68744496
154Hypoplasia of the pons (HP:0012110)1.68678457
155Aplasia/Hypoplasia of the sternum (HP:0006714)1.67301669
156Glioma (HP:0009733)1.66941883
157Renal cortical cysts (HP:0000803)1.66365338
158Occipital encephalocele (HP:0002085)1.66012655
159Recurrent pneumonia (HP:0006532)1.64528642
160Cystic liver disease (HP:0006706)1.62754429
161Nephropathy (HP:0000112)1.60846701
162Vaginal atresia (HP:0000148)1.60291697
163Abnormality of molar morphology (HP:0011070)1.59785538
164Abnormality of molar (HP:0011077)1.59785538
165Recurrent abscess formation (HP:0002722)1.59746189
166Prolonged neonatal jaundice (HP:0006579)1.57932304
167White forelock (HP:0002211)1.57752464
168Hypergonadotropic hypogonadism (HP:0000815)1.57297936
169Male pseudohermaphroditism (HP:0000037)1.57248265
170Embryonal renal neoplasm (HP:0011794)1.57084748

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK44.82691368
2PDK34.82691368
3PDK23.82957716
4BUB13.78252372
5CDC72.85868734
6TESK12.74788954
7ZAK2.64735555
8TRIM282.38367944
9CASK2.36095394
10SIK32.33907570
11MAP3K142.28985496
12TXK2.24021416
13PLK42.17668252
14IRAK42.12907988
15IRAK32.00737009
16BMPR1B2.00638245
17BMPR21.96004970
18AKT31.91724615
19YES11.86699601
20VRK21.78644568
21FRK1.76430852
22IRAK11.75465004
23MAP2K71.68984733
24PNCK1.68727343
25EPHA41.63090790
26ERBB31.62940646
27ACVR1B1.61389202
28STK38L1.60108928
29NEK11.59723131
30STK161.59201413
31BRSK11.57302422
32PRKD31.55515039
33EIF2AK21.54146697
34INSRR1.52999446
35IRAK21.47664872
36NEK61.45585182
37TSSK61.43438097
38ADRBK21.43074025
39SRPK11.35822968
40PTK2B1.33884260
41MAP4K21.32836304
42TAF11.32629077
43BCR1.30736698
44DYRK21.30520019
45MINK11.29311736
46FGFR21.25060004
47NEK21.17673621
48TNIK1.16742031
49CDK81.13215417
50CCNB11.07675005
51RIPK41.07361101
52ERBB41.06467778
53NME11.04870420
54SGK21.03668806
55PBK1.02972797
56NTRK31.01325994
57MKNK21.00317436
58TNK20.98568906
59ATR0.96017939
60VRK10.93989818
61EIF2AK10.93804949
62NUAK10.92969069
63MAP3K120.91077286
64PAK30.90579580
65CDK30.89355657
66OXSR10.89249287
67PINK10.86853928
68PKN10.86502821
69IKBKB0.85805995
70PRKCG0.84141934
71MUSK0.83211285
72MAP2K60.83193836
73EPHA30.82741941
74PRPF4B0.82572089
75GRK10.82425451
76CSNK1G20.80715044
77CHEK20.77072690
78BRAF0.76770208
79MST40.75974060
80AURKB0.74572316
81CSNK1G10.74079692
82CDK190.74040926
83ARAF0.71947591
84NLK0.71068296
85IKBKE0.70777912
86CSNK1G30.70001103
87NTRK20.69985045
88MAPK130.69959013
89MKNK10.67825121
90PIM20.67164209
91TRPM70.66576942
92TEC0.66510974
93STK240.66469743
94FGFR10.64554517
95BCKDK0.63400284
96JAK30.63050847
97GRK70.63000850
98WNK40.61907551
99DMPK0.61640376
100WNK30.60140787
101CHUK0.59785615
102TTK0.59035029
103CLK10.58466814
104STK30.57759314
105STK390.56606198
106MAP3K40.53771762
107STK40.53204106
108DYRK30.52482076
109EIF2AK30.52074717
110CSNK1E0.51533568
111CSNK1A1L0.51102588
112ALK0.49989641
113STK380.46839785
114RPS6KB10.45893676
115PRKDC0.45885459
116CDK10.45652530
117MARK30.45477117
118MAP3K80.44566010
119BRSK20.44449943
120PIM10.44291374
121PIK3CG0.43754425
122RAF10.43659631
123CAMK1G0.43006693
124CSNK2A20.42494017
125CDK20.42053812
126LYN0.42051498
127PRKCI0.41407490
128ATM0.41197347
129WEE10.40517284
130SGK2230.40342840
131SGK4940.40342840
132MARK10.39855514
133PASK0.38701953
134BRD40.38490152
135EPHB20.37854364
136TGFBR10.37429770
137CDK70.37265675
138CSNK1A10.36847507
139PLK20.36668666
140PRKCD0.36511042
141BTK0.36506920
142PLK10.35510879
143TIE10.34076722
144TAOK20.33860590
145PDK10.33083051
146CHEK10.32697729
147TBK10.32617663
148PRKCQ0.32158858
149CSNK2A10.31909056
150KIT0.31563053
151PLK30.28862088
152PRKCE0.28027205
153WNK10.27954784

Predicted pathways (KEGG)

RankGene SetZ-score
1Fanconi anemia pathway_Homo sapiens_hsa034603.34507817
2Basal transcription factors_Homo sapiens_hsa030223.17551126
3Homologous recombination_Homo sapiens_hsa034402.83168373
4Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.72331993
5Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.47830147
6Graft-versus-host disease_Homo sapiens_hsa053322.32376446
7Oxidative phosphorylation_Homo sapiens_hsa001902.26847630
8Parkinsons disease_Homo sapiens_hsa050122.22056843
9Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.11876549
10Allograft rejection_Homo sapiens_hsa053302.05896763
11Vitamin B6 metabolism_Homo sapiens_hsa007501.98504828
12Ribosome_Homo sapiens_hsa030101.90994155
13Propanoate metabolism_Homo sapiens_hsa006401.89377305
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.81984915
15Measles_Homo sapiens_hsa051621.73988479
16Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.73511262
17Rheumatoid arthritis_Homo sapiens_hsa053231.67450934
18alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.67239409
19Autoimmune thyroid disease_Homo sapiens_hsa053201.66312253
20Linoleic acid metabolism_Homo sapiens_hsa005911.65151195
21Intestinal immune network for IgA production_Homo sapiens_hsa046721.58317471
22Arachidonic acid metabolism_Homo sapiens_hsa005901.57837540
23Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.57836904
24NF-kappa B signaling pathway_Homo sapiens_hsa040641.57802364
25Purine metabolism_Homo sapiens_hsa002301.57039228
26Legionellosis_Homo sapiens_hsa051341.56300911
27SNARE interactions in vesicular transport_Homo sapiens_hsa041301.52603874
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.51877171
29Type I diabetes mellitus_Homo sapiens_hsa049401.46923150
30Glycosaminoglycan degradation_Homo sapiens_hsa005311.46461316
31Proteasome_Homo sapiens_hsa030501.39741614
32RNA degradation_Homo sapiens_hsa030181.39006259
33Non-homologous end-joining_Homo sapiens_hsa034501.38608153
34One carbon pool by folate_Homo sapiens_hsa006701.37709764
35Pyrimidine metabolism_Homo sapiens_hsa002401.37224886
36Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.36269806
37Steroid biosynthesis_Homo sapiens_hsa001001.33548974
38Pyruvate metabolism_Homo sapiens_hsa006201.33246653
39Herpes simplex infection_Homo sapiens_hsa051681.32690240
40Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.32116140
41Cysteine and methionine metabolism_Homo sapiens_hsa002701.31755560
42Asthma_Homo sapiens_hsa053101.27574864
43RNA polymerase_Homo sapiens_hsa030201.27225878
44Collecting duct acid secretion_Homo sapiens_hsa049661.27077402
45Mismatch repair_Homo sapiens_hsa034301.26763005
46DNA replication_Homo sapiens_hsa030301.26551383
47NOD-like receptor signaling pathway_Homo sapiens_hsa046211.26535299
48Alzheimers disease_Homo sapiens_hsa050101.25998856
49Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.25432842
50Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.24488258
51Folate biosynthesis_Homo sapiens_hsa007901.24373202
52Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.20650181
53Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.19904669
54Base excision repair_Homo sapiens_hsa034101.19434086
55Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.18813578
56Hematopoietic cell lineage_Homo sapiens_hsa046401.17703185
57Influenza A_Homo sapiens_hsa051641.14022293
58Toll-like receptor signaling pathway_Homo sapiens_hsa046201.13811908
59Oocyte meiosis_Homo sapiens_hsa041141.13660935
60Ether lipid metabolism_Homo sapiens_hsa005651.08916186
61Sphingolipid metabolism_Homo sapiens_hsa006001.08222119
62Selenocompound metabolism_Homo sapiens_hsa004501.06180774
63Nucleotide excision repair_Homo sapiens_hsa034201.03257039
64Primary immunodeficiency_Homo sapiens_hsa053401.02454885
65Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.01895050
66Protein export_Homo sapiens_hsa030601.01796153
67Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.01475897
68Cardiac muscle contraction_Homo sapiens_hsa042601.00348453
69Fatty acid elongation_Homo sapiens_hsa000620.99022236
70Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.96913398
71Fatty acid biosynthesis_Homo sapiens_hsa000610.96543964
72Mineral absorption_Homo sapiens_hsa049780.95392130
73Nicotine addiction_Homo sapiens_hsa050330.94943120
74Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.94097128
75RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.90941334
76Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.90502435
77Phagosome_Homo sapiens_hsa041450.89165700
78Huntingtons disease_Homo sapiens_hsa050160.88817465
79Cell cycle_Homo sapiens_hsa041100.87046100
80Leishmaniasis_Homo sapiens_hsa051400.84187118
81Butanoate metabolism_Homo sapiens_hsa006500.83493914
82Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.81789902
83Antigen processing and presentation_Homo sapiens_hsa046120.79319595
84Jak-STAT signaling pathway_Homo sapiens_hsa046300.74914578
852-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.74002252
86mRNA surveillance pathway_Homo sapiens_hsa030150.73348765
87RNA transport_Homo sapiens_hsa030130.73132787
88Other glycan degradation_Homo sapiens_hsa005110.71772725
89Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.71266361
90Vitamin digestion and absorption_Homo sapiens_hsa049770.70542586
91TNF signaling pathway_Homo sapiens_hsa046680.68710186
92Epstein-Barr virus infection_Homo sapiens_hsa051690.66815407
93Taste transduction_Homo sapiens_hsa047420.65612201
94Basal cell carcinoma_Homo sapiens_hsa052170.64480622
95p53 signaling pathway_Homo sapiens_hsa041150.64199524
96Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.64174841
97Nitrogen metabolism_Homo sapiens_hsa009100.62927754
98Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.62369845
99Steroid hormone biosynthesis_Homo sapiens_hsa001400.60970730
100Salmonella infection_Homo sapiens_hsa051320.60675577
101Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.60217421
102Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.60178316
103Malaria_Homo sapiens_hsa051440.59951805
104African trypanosomiasis_Homo sapiens_hsa051430.59793166
105Pentose and glucuronate interconversions_Homo sapiens_hsa000400.56708370
106Spliceosome_Homo sapiens_hsa030400.56495263
107Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.54421399
108Pentose phosphate pathway_Homo sapiens_hsa000300.53940031
109Retinol metabolism_Homo sapiens_hsa008300.52777589
110Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.52018687
111Tuberculosis_Homo sapiens_hsa051520.51286012
112Glutathione metabolism_Homo sapiens_hsa004800.51249854
113Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.50682135
114Wnt signaling pathway_Homo sapiens_hsa043100.50662319
115Hedgehog signaling pathway_Homo sapiens_hsa043400.49406053
116Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.48500612
117Phototransduction_Homo sapiens_hsa047440.48452380
118Peroxisome_Homo sapiens_hsa041460.47583815
119Olfactory transduction_Homo sapiens_hsa047400.45205964
120Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.44542164
121Sulfur relay system_Homo sapiens_hsa041220.44517667
122Synaptic vesicle cycle_Homo sapiens_hsa047210.44467601
123beta-Alanine metabolism_Homo sapiens_hsa004100.43942932
124Transcriptional misregulation in cancer_Homo sapiens_hsa052020.43798333
125Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.43337452
126Carbon metabolism_Homo sapiens_hsa012000.42923525
127Fructose and mannose metabolism_Homo sapiens_hsa000510.42719777
128Tryptophan metabolism_Homo sapiens_hsa003800.42016615
129Hippo signaling pathway_Homo sapiens_hsa043900.41876104
130Fatty acid metabolism_Homo sapiens_hsa012120.41506703
131Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.41218845
132Calcium signaling pathway_Homo sapiens_hsa040200.40417402
133Morphine addiction_Homo sapiens_hsa050320.39907646
134Glycerophospholipid metabolism_Homo sapiens_hsa005640.39880183
135Inositol phosphate metabolism_Homo sapiens_hsa005620.39742105
136Osteoclast differentiation_Homo sapiens_hsa043800.39206237
137Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.37617406
138Fatty acid degradation_Homo sapiens_hsa000710.36927607
139Chemical carcinogenesis_Homo sapiens_hsa052040.36876165
140Metabolic pathways_Homo sapiens_hsa011000.36783683
141Biosynthesis of amino acids_Homo sapiens_hsa012300.36711501
142Fat digestion and absorption_Homo sapiens_hsa049750.36007831
143Regulation of autophagy_Homo sapiens_hsa041400.35842780
144Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.34749941
145Dopaminergic synapse_Homo sapiens_hsa047280.33565455
146Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.32120000
147Serotonergic synapse_Homo sapiens_hsa047260.30289831
148Toxoplasmosis_Homo sapiens_hsa051450.30204470
149ABC transporters_Homo sapiens_hsa020100.30185687
150Maturity onset diabetes of the young_Homo sapiens_hsa049500.29374590
151Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.28881178
152TGF-beta signaling pathway_Homo sapiens_hsa043500.28754826
153Lysine degradation_Homo sapiens_hsa003100.28261841
154Axon guidance_Homo sapiens_hsa043600.27429165
155Glycerolipid metabolism_Homo sapiens_hsa005610.27044792
156Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.26410348
157Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.23495948
158Arginine and proline metabolism_Homo sapiens_hsa003300.21735581
159Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.21011431
160Glutamatergic synapse_Homo sapiens_hsa047240.19449356

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