ACSBG1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene possesses long-chain acyl-CoA synthetase activity. It is thought to play a central role in brain very long-chain fatty acids metabolism and myelinogenesis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sodium ion export (GO:0071436)5.62246646
2cellular potassium ion homeostasis (GO:0030007)5.60522670
3L-amino acid import (GO:0043092)5.18213009
4locomotory exploration behavior (GO:0035641)4.99678477
5fatty acid elongation (GO:0030497)4.79980103
6amino acid import (GO:0043090)4.74026011
7negative regulation of amyloid precursor protein catabolic process (GO:1902992)4.66352045
8synaptic vesicle maturation (GO:0016188)4.58100299
9C4-dicarboxylate transport (GO:0015740)4.40968954
10alanine transport (GO:0032328)4.38591105
11regulation of short-term neuronal synaptic plasticity (GO:0048172)4.35350156
12gamma-aminobutyric acid transport (GO:0015812)4.32893943
13one-carbon compound transport (GO:0019755)4.32128379
14cell communication by electrical coupling (GO:0010644)4.31096247
15layer formation in cerebral cortex (GO:0021819)4.27094446
16gonadal mesoderm development (GO:0007506)4.26515213
17glial cell proliferation (GO:0014009)4.25296718
18potassium ion homeostasis (GO:0055075)4.18078668
19neurotransmitter-gated ion channel clustering (GO:0072578)4.13480378
20potassium ion import (GO:0010107)4.06745244
21postsynaptic membrane organization (GO:0001941)4.06498992
22ovulation cycle (GO:0042698)3.93639910
23cilium or flagellum-dependent cell motility (GO:0001539)3.91528794
24positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.87981438
25cellular sodium ion homeostasis (GO:0006883)3.85419107
26cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.83546938
27synaptic vesicle exocytosis (GO:0016079)3.81248667
28regulation of cilium movement (GO:0003352)3.78669841
29positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.76291350
30response to auditory stimulus (GO:0010996)3.76280719
31glutamate secretion (GO:0014047)3.74890338
32positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.74140002
33synaptic vesicle docking involved in exocytosis (GO:0016081)3.66867904
34epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.63258270
35neuronal action potential propagation (GO:0019227)3.62700580
36regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.61170473
37long-chain fatty acid biosynthetic process (GO:0042759)3.57089212
38regulation of synaptic vesicle exocytosis (GO:2000300)3.56785951
39cilium movement (GO:0003341)3.55437295
40neurotransmitter secretion (GO:0007269)3.54817674
41regulation of beta-amyloid formation (GO:1902003)3.53994851
42vocalization behavior (GO:0071625)3.52186616
43positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.52122304
44regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.51990377
45membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.50641653
46ionotropic glutamate receptor signaling pathway (GO:0035235)3.48388093
47regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.47007847
48regulation of neuronal synaptic plasticity (GO:0048168)3.46723607
49auditory behavior (GO:0031223)3.45800784
50regulation of synapse structural plasticity (GO:0051823)3.43687017
51regulation of voltage-gated calcium channel activity (GO:1901385)3.42194801
52negative regulation of astrocyte differentiation (GO:0048712)3.42176457
53molting cycle (GO:0042303)3.39623327
54hair cycle (GO:0042633)3.39623327
55epithelial cilium movement (GO:0003351)3.38931913
56negative regulation of heart rate (GO:0010459)3.38015924
57negative regulation of appetite (GO:0032099)3.37126161
58negative regulation of response to food (GO:0032096)3.37126161
59presynaptic membrane assembly (GO:0097105)3.36680956
60cellular response to cholesterol (GO:0071397)3.34673789
61glutamate receptor signaling pathway (GO:0007215)3.33200910
62exploration behavior (GO:0035640)3.32340350
63axoneme assembly (GO:0035082)3.31424930
64regulation of neurotransmitter uptake (GO:0051580)3.26131302
65proline transport (GO:0015824)3.25800942
66synaptic transmission, glutamatergic (GO:0035249)3.24647178
67acidic amino acid transport (GO:0015800)3.23370116
68regulation of glutamate receptor signaling pathway (GO:1900449)3.23113341
69G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.22675795
70membrane repolarization (GO:0086009)3.22513960
71cerebellar granule cell differentiation (GO:0021707)3.22197282
72membrane depolarization during action potential (GO:0086010)3.21545578
73positive regulation of potassium ion transmembrane transport (GO:1901381)3.15769480
74positive regulation of cellular amide metabolic process (GO:0034250)3.14333497
75negative regulation of synaptic transmission, GABAergic (GO:0032229)3.13831343
76regulation of long-term neuronal synaptic plasticity (GO:0048169)3.12016718
77regulation of synaptic vesicle transport (GO:1902803)3.11031899
78regulation of amyloid precursor protein catabolic process (GO:1902991)3.08427174
79L-serine transport (GO:0015825)3.08230911
80negative regulation of neurotransmitter transport (GO:0051589)3.08160275
81axonemal dynein complex assembly (GO:0070286)3.07879912
82chondroitin sulfate catabolic process (GO:0030207)3.06371458
83presynaptic membrane organization (GO:0097090)3.04722958
84long-term memory (GO:0007616)3.01197587
85transmission of nerve impulse (GO:0019226)3.00371629
86regulation of synaptic transmission, glutamatergic (GO:0051966)2.98543893
87glycine transport (GO:0015816)2.97423581
88detection of light stimulus involved in sensory perception (GO:0050962)2.96138370
89detection of light stimulus involved in visual perception (GO:0050908)2.96138370
90neuromuscular process controlling balance (GO:0050885)2.96060808
91serotonin metabolic process (GO:0042428)2.95192920
92L-glutamate transport (GO:0015813)2.92906098
93negative regulation of sodium ion transport (GO:0010766)2.92667329
94detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.92107339
95regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.90636521
96cellular response to sterol (GO:0036315)2.90629079
97estrogen biosynthetic process (GO:0006703)2.89208089
98mechanosensory behavior (GO:0007638)2.88810917
99neurotransmitter transport (GO:0006836)2.87703784
100photoreceptor cell maintenance (GO:0045494)2.86035225
101neurotransmitter uptake (GO:0001504)2.85686421
102regulation of neurotransmitter transport (GO:0051588)2.85214167
103regulation of microtubule-based movement (GO:0060632)2.83840923
104neuron-neuron synaptic transmission (GO:0007270)2.82691145
105protein localization to synapse (GO:0035418)2.81324614
106myelination in peripheral nervous system (GO:0022011)2.81028705
107peripheral nervous system axon ensheathment (GO:0032292)2.81028705
108gamma-aminobutyric acid signaling pathway (GO:0007214)2.79060238
109regulation of neurotransmitter levels (GO:0001505)2.78154104
110dendrite morphogenesis (GO:0048813)2.77387648
111regulation of female receptivity (GO:0045924)2.77370824
112retinal cone cell development (GO:0046549)2.76797120
113positive regulation of potassium ion transport (GO:0043268)2.76284662
114regulation of neurotransmitter secretion (GO:0046928)2.75806566
115positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.74637161
116cellular response to cadmium ion (GO:0071276)2.74326695
117regulation of synaptic plasticity (GO:0048167)2.74253470
118primary amino compound metabolic process (GO:1901160)2.72908733
119dermatan sulfate metabolic process (GO:0030205)2.72120657
120regulation of response to food (GO:0032095)2.71933325
121behavioral response to nicotine (GO:0035095)2.71910409
122positive regulation of sodium ion transmembrane transport (GO:1902307)2.70929778
123long-term synaptic potentiation (GO:0060291)2.70336055
124protein K11-linked deubiquitination (GO:0035871)2.70001088
125adult walking behavior (GO:0007628)2.69943450
126axon ensheathment in central nervous system (GO:0032291)2.69810037
127central nervous system myelination (GO:0022010)2.69810037
128dermatan sulfate biosynthetic process (GO:0030208)2.69281284
129prepulse inhibition (GO:0060134)2.67604315
130cerebellar Purkinje cell differentiation (GO:0021702)2.67311582
131neuron cell-cell adhesion (GO:0007158)2.66329040
132regulation of vesicle fusion (GO:0031338)2.66072532
133establishment of skin barrier (GO:0061436)2.65655627
134positive regulation of male gonad development (GO:2000020)2.65506896
135adaptation of signaling pathway (GO:0023058)2.65440655
136positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.64696058
137innervation (GO:0060384)2.64349364
138cellular potassium ion transport (GO:0071804)2.63582416
139potassium ion transmembrane transport (GO:0071805)2.63582416
140establishment of nucleus localization (GO:0040023)2.61305579
141mating behavior (GO:0007617)2.60286978
142regulation of sensory perception of pain (GO:0051930)2.58641148
143regulation of sensory perception (GO:0051931)2.58641148
144serine transport (GO:0032329)2.57891569
145neuromuscular process controlling posture (GO:0050884)2.57713871
146negative regulation of cytosolic calcium ion concentration (GO:0051481)2.57009401
147positive regulation of meiosis (GO:0045836)2.55989643
148behavioral response to cocaine (GO:0048148)2.55392292
149negative regulation of protein localization to cell surface (GO:2000009)2.53967194
150startle response (GO:0001964)2.53811774
151linoleic acid metabolic process (GO:0043651)2.53335526
152regulation of collateral sprouting (GO:0048670)2.52431341
153fucose catabolic process (GO:0019317)2.51459670
154L-fucose metabolic process (GO:0042354)2.51459670
155L-fucose catabolic process (GO:0042355)2.51459670
156regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.50254953

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.55156034
2SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.08800868
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.86697970
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.76456615
5EZH2_18974828_ChIP-Seq_MESCs_Mouse2.66654027
6RNF2_18974828_ChIP-Seq_MESCs_Mouse2.66654027
7SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.65196047
8IKZF1_21737484_ChIP-ChIP_HCT116_Human2.63884332
9IGF1R_20145208_ChIP-Seq_DFB_Human2.56297177
10MTF2_20144788_ChIP-Seq_MESCs_Mouse2.55758446
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.53361139
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.50343014
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.45734607
14DROSHA_22980978_ChIP-Seq_HELA_Human2.44661009
15SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.44102883
16RNF2_27304074_Chip-Seq_ESCs_Mouse2.34943363
17VDR_22108803_ChIP-Seq_LS180_Human2.31347185
18EED_16625203_ChIP-ChIP_MESCs_Mouse2.30731599
19EZH2_27304074_Chip-Seq_ESCs_Mouse2.22766839
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.17127262
21ZFP57_27257070_Chip-Seq_ESCs_Mouse2.16537792
22POU3F2_20337985_ChIP-ChIP_501MEL_Human2.16357429
23AR_21572438_ChIP-Seq_LNCaP_Human2.14673254
24RARB_27405468_Chip-Seq_BRAIN_Mouse2.14350715
25REST_21632747_ChIP-Seq_MESCs_Mouse2.13087401
26EZH2_27294783_Chip-Seq_ESCs_Mouse2.12880918
27TAF15_26573619_Chip-Seq_HEK293_Human2.06152341
28EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.05291602
29MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.95250339
30ERG_21242973_ChIP-ChIP_JURKAT_Human1.89266316
31AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.85201055
32P300_19829295_ChIP-Seq_ESCs_Human1.83423003
33GBX2_23144817_ChIP-Seq_PC3_Human1.79421684
34REST_18959480_ChIP-ChIP_MESCs_Mouse1.72002520
35CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.70698566
36TP63_17297297_ChIP-ChIP_HaCaT_Human1.69009769
37PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.65800890
38ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.63545113
39TCF4_23295773_ChIP-Seq_U87_Human1.61865939
40ER_23166858_ChIP-Seq_MCF-7_Human1.58555854
41UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.55027103
42FLI1_27457419_Chip-Seq_LIVER_Mouse1.54975118
43HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.53063399
44RING1B_27294783_Chip-Seq_ESCs_Mouse1.46509663
45MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.42086492
46TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40525138
47POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.40525138
48THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.39933167
49DNAJC2_21179169_ChIP-ChIP_NT2_Human1.39274921
50RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.38779650
51TCF4_22108803_ChIP-Seq_LS180_Human1.38146341
52OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36257884
53FUS_26573619_Chip-Seq_HEK293_Human1.35825094
54KDM2B_26808549_Chip-Seq_K562_Human1.34276373
55IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.32194408
56CBP_20019798_ChIP-Seq_JUKART_Human1.32194408
57* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.31716734
58TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.30757413
59TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.29928289
60TOP2B_26459242_ChIP-Seq_MCF-7_Human1.28553887
61PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.27191674
62SMAD4_21741376_ChIP-Seq_EPCs_Human1.26835020
63WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.26396205
64WT1_25993318_ChIP-Seq_PODOCYTE_Human1.25631078
65ZFP281_18757296_ChIP-ChIP_E14_Mouse1.24972286
66CBX2_27304074_Chip-Seq_ESCs_Mouse1.24327823
67EWS_26573619_Chip-Seq_HEK293_Human1.23426863
68RUNX2_22187159_ChIP-Seq_PCA_Human1.23360738
69PRDM14_20953172_ChIP-Seq_ESCs_Human1.22454044
70ESR2_21235772_ChIP-Seq_MCF-7_Human1.21882669
71GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.21713736
72EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.20256606
73RXR_22108803_ChIP-Seq_LS180_Human1.17388995
74KLF5_20875108_ChIP-Seq_MESCs_Mouse1.17387698
75CDX2_19796622_ChIP-Seq_MESCs_Mouse1.17172615
76SOX2_19829295_ChIP-Seq_ESCs_Human1.17150931
77NANOG_19829295_ChIP-Seq_ESCs_Human1.17150931
78NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.16734570
79TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16573262
80AR_19668381_ChIP-Seq_PC3_Human1.16247613
81PCGF2_27294783_Chip-Seq_ESCs_Mouse1.15025369
82RNF2_27304074_Chip-Seq_NSC_Mouse1.14662682
83CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14552618
84NANOG_18555785_Chip-Seq_ESCs_Mouse1.13486458
85STAT6_21828071_ChIP-Seq_BEAS2B_Human1.12235066
86TP53_20018659_ChIP-ChIP_R1E_Mouse1.11457349
87SUZ12_27294783_Chip-Seq_NPCs_Mouse1.11052901
88RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.09921029
89SMAD_19615063_ChIP-ChIP_OVARY_Human1.08660744
90RING1B_27294783_Chip-Seq_NPCs_Mouse1.08477019
91SMAD4_21799915_ChIP-Seq_A2780_Human1.08457356
92EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.08333415
93P53_22387025_ChIP-Seq_ESCs_Mouse1.08311301
94MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.05359470
95FLI1_21867929_ChIP-Seq_TH2_Mouse1.04812632
96SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04464164
97EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.04445614
98FOXA1_25329375_ChIP-Seq_VCAP_Human1.04279078
99FOXA1_27270436_Chip-Seq_PROSTATE_Human1.04279078
100CTBP1_25329375_ChIP-Seq_LNCAP_Human1.03992136
101TP53_16413492_ChIP-PET_HCT116_Human1.03709714
102EZH2_27294783_Chip-Seq_NPCs_Mouse1.03582385
103* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.03415262
104SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.02655992
105CTBP2_25329375_ChIP-Seq_LNCAP_Human1.02550765
106FOXA1_21572438_ChIP-Seq_LNCaP_Human1.02549285
107TAL1_26923725_Chip-Seq_HPCs_Mouse1.02295798
108SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.01993413
109BCAT_22108803_ChIP-Seq_LS180_Human1.01681600
110SOX2_21211035_ChIP-Seq_LN229_Gbm1.01443234
111SMAD3_21741376_ChIP-Seq_ESCs_Human0.99966164
112ZFP281_27345836_Chip-Seq_ESCs_Mouse0.99869623
113MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.99579236
114KDM2B_26808549_Chip-Seq_REH_Human0.99548918
115AR_25329375_ChIP-Seq_VCAP_Human0.99272844
116NR3C1_23031785_ChIP-Seq_PC12_Mouse0.99145704
117GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98888585
118E2F1_18555785_Chip-Seq_ESCs_Mouse0.98593621
119TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.98370618
120* PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.96875296
121OCT1_27270436_Chip-Seq_PROSTATE_Human0.96851890
122HTT_18923047_ChIP-ChIP_STHdh_Human0.96746706
123TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.96414351
124BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.96317752
125CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.95200248
126ZNF274_21170338_ChIP-Seq_K562_Hela0.94017937
127TET1_21490601_ChIP-Seq_MESCs_Mouse0.93346911
128PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.93083546
129NR3C1_21868756_ChIP-Seq_MCF10A_Human0.90319845
130ARNT_22903824_ChIP-Seq_MCF-7_Human0.90304246
131ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.89060679
132SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.88031138
133YAP1_20516196_ChIP-Seq_MESCs_Mouse0.87997252
134ESR1_15608294_ChIP-ChIP_MCF-7_Human0.87392035
135GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86670263
136STAT3_23295773_ChIP-Seq_U87_Human0.86614898
137SMAD3_21741376_ChIP-Seq_HESCs_Human0.86603322
138PIAS1_25552417_ChIP-Seq_VCAP_Human0.85902928
139SMAD4_21741376_ChIP-Seq_HESCs_Human0.85801577
140TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.85782890
141KDM2B_26808549_Chip-Seq_SUP-B15_Human0.83998728
142ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.83561369
143CTCF_27219007_Chip-Seq_Bcells_Human0.83424752
144AHR_22903824_ChIP-Seq_MCF-7_Human0.83342669
145TRIM28_21343339_ChIP-Seq_HEK293_Human0.83326780
146SMAD3_21741376_ChIP-Seq_EPCs_Human0.82442786
147SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.82209384
148EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.82084372
149TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.82019209
150TP53_18474530_ChIP-ChIP_U2OS_Human0.82017479
151LXR_22292898_ChIP-Seq_THP-1_Human0.81710306
152OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.79125981
153SMC4_20622854_ChIP-Seq_HELA_Human0.78346020

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.16459041
2MP0003635_abnormal_synaptic_transmissio3.32337902
3MP0003329_amyloid_beta_deposits3.23464044
4MP0004858_abnormal_nervous_system3.08162643
5MP0009046_muscle_twitch2.92459325
6MP0003690_abnormal_glial_cell2.82089893
7MP0004885_abnormal_endolymph2.80756486
8MP0009745_abnormal_behavioral_response2.67876508
9MP0001486_abnormal_startle_reflex2.67135627
10MP0002064_seizures2.61179687
11MP0004270_analgesia2.59574597
12MP0002063_abnormal_learning/memory/cond2.55543667
13MP0009780_abnormal_chondrocyte_physiolo2.48860266
14MP0005377_hearing/vestibular/ear_phenot2.48006625
15MP0003878_abnormal_ear_physiology2.48006625
16MP0002909_abnormal_adrenal_gland2.44511441
17MP0003880_abnormal_central_pattern2.42768199
18MP0008569_lethality_at_weaning2.42295246
19MP0005423_abnormal_somatic_nervous2.32812046
20MP0002572_abnormal_emotion/affect_behav2.32811626
21MP0002254_reproductive_system_inflammat2.29140732
22MP0005646_abnormal_pituitary_gland2.26842601
23MP0001440_abnormal_grooming_behavior2.21916468
24MP0001968_abnormal_touch/_nociception2.07747983
25MP0009384_cardiac_valve_regurgitation1.99995551
26MP0002272_abnormal_nervous_system1.99616560
27MP0005174_abnormal_tail_pigmentation1.97679527
28MP0001984_abnormal_olfaction1.92616252
29MP0002734_abnormal_mechanical_nocicepti1.83496999
30MP0002733_abnormal_thermal_nociception1.83472483
31MP0002557_abnormal_social/conspecific_i1.78121614
32MP0002736_abnormal_nociception_after1.76405368
33MP0001501_abnormal_sleep_pattern1.74084093
34MP0002095_abnormal_skin_pigmentation1.65482048
35MP0002067_abnormal_sensory_capabilities1.63857157
36MP0003634_abnormal_glial_cell1.63644596
37MP0001502_abnormal_circadian_rhythm1.61638754
38MP0000604_amyloidosis1.60959084
39MP0002822_catalepsy1.59996449
40MP0006276_abnormal_autonomic_nervous1.59847190
41MP0004147_increased_porphyrin_level1.58659384
42MP0000569_abnormal_digit_pigmentation1.54658494
43MP0003633_abnormal_nervous_system1.53750924
44MP0001970_abnormal_pain_threshold1.53561715
45MP0004381_abnormal_hair_follicle1.50963970
46MP0001986_abnormal_taste_sensitivity1.50007530
47MP0003011_delayed_dark_adaptation1.49136575
48MP0003632_abnormal_nervous_system1.45946719
49MP0000383_abnormal_hair_follicle1.42446332
50MP0000579_abnormal_nail_morphology1.41177987
51MP0003631_nervous_system_phenotype1.39112332
52MP0000778_abnormal_nervous_system1.38703929
53MP0000427_abnormal_hair_cycle1.37246089
54MP0003075_altered_response_to1.32242959
55MP0008995_early_reproductive_senescence1.27465232
56MP0001485_abnormal_pinna_reflex1.25122282
57MP0000955_abnormal_spinal_cord1.24661387
58MP0000751_myopathy1.23995984
59MP0005623_abnormal_meninges_morphology1.22989439
60MP0005464_abnormal_platelet_physiology1.20139235
61MP0002882_abnormal_neuron_morphology1.19217660
62MP0002090_abnormal_vision1.17501290
63MP0000015_abnormal_ear_pigmentation1.17203356
64MP0005410_abnormal_fertilization1.17060409
65MP0008875_abnormal_xenobiotic_pharmacok1.15069997
66MP0002184_abnormal_innervation1.14723550
67MP0003045_fibrosis1.14575071
68MP0003787_abnormal_imprinting1.14554989
69MP0009379_abnormal_foot_pigmentation1.13851185
70MP0001188_hyperpigmentation1.11830714
71MP0002796_impaired_skin_barrier1.11190449
72MP0003879_abnormal_hair_cell1.10113859
73MP0004142_abnormal_muscle_tone1.09975727
74MP0002066_abnormal_motor_capabilities/c1.09390981
75MP0002102_abnormal_ear_morphology1.09347859
76MP0004924_abnormal_behavior1.08487360
77MP0005386_behavior/neurological_phenoty1.08487360
78MP0000647_abnormal_sebaceous_gland1.08194654
79MP0000639_abnormal_adrenal_gland1.07470128
80MP0005167_abnormal_blood-brain_barrier1.07089176
81MP0004811_abnormal_neuron_physiology1.04505996
82MP0002152_abnormal_brain_morphology1.02492810
83MP0005645_abnormal_hypothalamus_physiol1.01995024
84MP0002735_abnormal_chemical_nociception0.99332087
85MP0002098_abnormal_vibrissa_morphology0.98274986
86MP0006072_abnormal_retinal_apoptosis0.97106789
87MP0001299_abnormal_eye_distance/0.96834836
88MP0003136_yellow_coat_color0.96570594
89MP0005075_abnormal_melanosome_morpholog0.96005241
90MP0010678_abnormal_skin_adnexa0.95242064
91MP0002653_abnormal_ependyma_morphology0.94781085
92MP0002089_abnormal_postnatal_growth/wei0.94432074
93MP0000920_abnormal_myelination0.92435712
94MP0004145_abnormal_muscle_electrophysio0.91626094
95MP0000372_irregular_coat_pigmentation0.88886390
96MP0003279_aneurysm0.86421078
97MP0005551_abnormal_eye_electrophysiolog0.85849082
98MP0001177_atelectasis0.85759888
99MP0002638_abnormal_pupillary_reflex0.85393652
100MP0000026_abnormal_inner_ear0.84676269
101MP0000631_abnormal_neuroendocrine_gland0.83528375
102MP0000230_abnormal_systemic_arterial0.82697976
103MP0010386_abnormal_urinary_bladder0.80627231
104MP0004742_abnormal_vestibular_system0.79892575
105MP0003137_abnormal_impulse_conducting0.76702994
106MP0002229_neurodegeneration0.75322592
107MP0003638_abnormal_response/metabolism_0.74484523
108MP0002752_abnormal_somatic_nervous0.74266461
109MP0004215_abnormal_myocardial_fiber0.73938699
110MP0005253_abnormal_eye_physiology0.73434217
111MP0001963_abnormal_hearing_physiology0.70862944
112MP0002876_abnormal_thyroid_physiology0.70773068
113MP0008872_abnormal_physiological_respon0.70197097
114MP0001905_abnormal_dopamine_level0.68138032
115MP0000566_synostosis0.67945974
116MP0000013_abnormal_adipose_tissue0.67484230
117MP0002069_abnormal_eating/drinking_beha0.66935649
118MP0008961_abnormal_basal_metabolism0.65831826
119MP0010771_integument_phenotype0.65596528
120MP0005595_abnormal_vascular_smooth0.64219484
121MP0008874_decreased_physiological_sensi0.64096402
122MP0001853_heart_inflammation0.63537713
123MP0001958_emphysema0.60885857
124MP0005171_absent_coat_pigmentation0.58144541
125MP0010234_abnormal_vibrissa_follicle0.57238009
126* MP0003698_abnormal_male_reproductive0.57161806
127MP0004130_abnormal_muscle_cell0.56843578
128MP0004043_abnormal_pH_regulation0.56670669
129MP0003183_abnormal_peptide_metabolism0.55549375
130MP0008877_abnormal_DNA_methylation0.53121028

Predicted human phenotypes

RankGene SetZ-score
1Megalencephaly (HP:0001355)6.04187161
2Aplasia involving bones of the upper limbs (HP:0009823)5.64243977
3Aplasia of the phalanges of the hand (HP:0009802)5.64243977
4Aplasia involving bones of the extremities (HP:0009825)5.64243977
5Myokymia (HP:0002411)4.97853596
6Focal motor seizures (HP:0011153)4.50294339
7Abnormal ciliary motility (HP:0012262)4.08264844
8Neurofibrillary tangles (HP:0002185)3.86616410
9Hemiplegia (HP:0002301)3.86225791
10Action tremor (HP:0002345)3.80847280
11Abnormal respiratory epithelium morphology (HP:0012253)3.77874984
12Abnormal respiratory motile cilium morphology (HP:0005938)3.77874984
13Progressive cerebellar ataxia (HP:0002073)3.77542216
14Dynein arm defect of respiratory motile cilia (HP:0012255)3.74540959
15Absent/shortened dynein arms (HP:0200106)3.74540959
16Abnormal respiratory motile cilium physiology (HP:0012261)3.63127004
17Focal seizures (HP:0007359)3.60663688
18Hemiparesis (HP:0001269)3.57018408
19Abnormality of binocular vision (HP:0011514)3.56148449
20Diplopia (HP:0000651)3.56148449
21Abnormality of the axillary hair (HP:0100134)3.36751636
22Abnormality of secondary sexual hair (HP:0009888)3.36751636
23Rhinitis (HP:0012384)3.34188568
24Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.28992942
25Hyperventilation (HP:0002883)3.25531678
26Visual hallucinations (HP:0002367)3.15963754
27Ankle clonus (HP:0011448)3.13852870
28Pancreatic cysts (HP:0001737)3.13643720
29Supranuclear gaze palsy (HP:0000605)3.13048857
30Cerebral inclusion bodies (HP:0100314)3.10303120
31Dysdiadochokinesis (HP:0002075)3.07434513
32Clumsiness (HP:0002312)3.04385155
33Epileptic encephalopathy (HP:0200134)3.04291092
34True hermaphroditism (HP:0010459)3.04030017
35Pancreatic fibrosis (HP:0100732)3.03348804
36Decreased central vision (HP:0007663)2.88547070
37Generalized tonic-clonic seizures (HP:0002069)2.88312343
38Congenital stationary night blindness (HP:0007642)2.87053820
39Abnormal sex determination (HP:0012244)2.84248223
40Sex reversal (HP:0012245)2.84248223
41Gait imbalance (HP:0002141)2.82018790
42Humeroradial synostosis (HP:0003041)2.78945242
43Synostosis involving the elbow (HP:0003938)2.78945242
44Medial flaring of the eyebrow (HP:0010747)2.77187462
45Gonadotropin excess (HP:0000837)2.68626127
46Hypoplastic left heart (HP:0004383)2.66849972
47Abnormality of midbrain morphology (HP:0002418)2.65936104
48Molar tooth sign on MRI (HP:0002419)2.65936104
49Gonadal dysgenesis (HP:0000133)2.65457736
50Onycholysis (HP:0001806)2.65078604
51Intention tremor (HP:0002080)2.64281290
52Depression (HP:0000716)2.62553707
53Truncal ataxia (HP:0002078)2.59753950
54Nephronophthisis (HP:0000090)2.57985356
55Chronic hepatic failure (HP:0100626)2.50676754
56Abnormal drinking behavior (HP:0030082)2.49868842
57Polydipsia (HP:0001959)2.49868842
58Mesangial abnormality (HP:0001966)2.48097325
59Congenital primary aphakia (HP:0007707)2.47012083
60Postural instability (HP:0002172)2.46915059
61Abnormal eating behavior (HP:0100738)2.44120500
62Status epilepticus (HP:0002133)2.43122421
63Male infertility (HP:0003251)2.42171265
64Absent speech (HP:0001344)2.36682610
65Split foot (HP:0001839)2.35339029
66Gaze-evoked nystagmus (HP:0000640)2.30087871
67Bronchomalacia (HP:0002780)2.28298912
68Abnormality of the renal cortex (HP:0011035)2.26708228
69Abnormality of the renal medulla (HP:0100957)2.24543000
70Atonic seizures (HP:0010819)2.23390761
71Central scotoma (HP:0000603)2.21334195
72Dysmetria (HP:0001310)2.20078589
73Attenuation of retinal blood vessels (HP:0007843)2.19920131
74Absence seizures (HP:0002121)2.19141369
75Erythroderma (HP:0001019)2.18298278
76Nephrogenic diabetes insipidus (HP:0009806)2.13978913
77Abnormality of nail color (HP:0100643)2.10362945
78Back pain (HP:0003418)2.08846664
79Hypoplasia of the uterus (HP:0000013)2.06197031
80Abnormality of macular pigmentation (HP:0008002)2.06090800
81Genital tract atresia (HP:0001827)2.05285037
82Insomnia (HP:0100785)2.04947202
83Impaired vibration sensation in the lower limbs (HP:0002166)2.04096811
84Hyperlipoproteinemia (HP:0010980)2.03552883
85Dialeptic seizures (HP:0011146)2.03417680
86Abnormality of the lower motor neuron (HP:0002366)2.02998551
87Prolonged bleeding time (HP:0003010)2.02807148
88Bronchiectasis (HP:0002110)2.02510640
89Ventricular fibrillation (HP:0001663)2.02139466
90Tetraplegia (HP:0002445)2.01852206
91Aplasia/hypoplasia of the uterus (HP:0008684)2.01679119
92Hypokalemic alkalosis (HP:0001949)2.01210774
93Abnormality of the middle phalanges of the toes (HP:0010183)2.01164519
94Cystic liver disease (HP:0006706)2.00551849
95Vaginal atresia (HP:0000148)2.00280228
96Anxiety (HP:0000739)2.00217660
97Hypoplasia of the fovea (HP:0007750)1.99962886
98Aplasia/Hypoplasia of the fovea (HP:0008060)1.99962886
99Abolished electroretinogram (ERG) (HP:0000550)1.98158229
100Limb ataxia (HP:0002070)1.96716877
101Narrow nasal bridge (HP:0000446)1.96170579
102Widely spaced teeth (HP:0000687)1.95103076
103Pseudobulbar signs (HP:0002200)1.94937651
104Exercise-induced myalgia (HP:0003738)1.94675148
105Dysmetric saccades (HP:0000641)1.93033933
106Conjunctival hamartoma (HP:0100780)1.92377063
107Hypoplastic heart (HP:0001961)1.90090318
108Absent hair (HP:0002298)1.89661756
109Genetic anticipation (HP:0003743)1.89151549
110Abnormality of ocular smooth pursuit (HP:0000617)1.88989370
111Hypomagnesemia (HP:0002917)1.88652457
112Polyphagia (HP:0002591)1.88240981
113Febrile seizures (HP:0002373)1.87546288
114Inability to walk (HP:0002540)1.87473803
115Enlarged penis (HP:0000040)1.87049261
116Hypotrichosis (HP:0001006)1.86423748
117Furrowed tongue (HP:0000221)1.86160707
118Testicular neoplasm (HP:0010788)1.86062051
119Broad-based gait (HP:0002136)1.85615625
120Urinary bladder sphincter dysfunction (HP:0002839)1.85532654
121Fair hair (HP:0002286)1.84666681
122Annular pancreas (HP:0001734)1.84057902
123Impaired smooth pursuit (HP:0007772)1.81527492
124Protruding tongue (HP:0010808)1.81499893
125Postural tremor (HP:0002174)1.81341161
126Increased circulating renin level (HP:0000848)1.80830385
127Broad alveolar ridges (HP:0000187)1.78617966
128Rigidity (HP:0002063)1.78355810
129Adactyly (HP:0009776)1.78282486
130Woolly hair (HP:0002224)1.78039125
131Metabolic alkalosis (HP:0200114)1.77871301
132Multifactorial inheritance (HP:0001426)1.77391524
133Abnormality of the dental pulp (HP:0006479)1.77377089
134Polyuria (HP:0000103)1.76522049
135Scanning speech (HP:0002168)1.74246586
136Short hallux (HP:0010109)1.72855173
137Aplasia/Hypoplasia of the tibia (HP:0005772)1.72778385
138Abnormality of saccadic eye movements (HP:0000570)1.72533946
139Lower limb muscle weakness (HP:0007340)1.72470734
140Mixed hearing impairment (HP:0000410)1.72264785
141Aplasia/Hypoplasia of the spleen (HP:0010451)1.72257340
142Dementia (HP:0000726)1.71961121
143Type II lissencephaly (HP:0007260)1.71856630
144Urinary urgency (HP:0000012)1.71830724
145Neuronal loss in central nervous system (HP:0002529)1.71602171
146Spastic gait (HP:0002064)1.71115878
147Pointed chin (HP:0000307)1.71115848
148Asplenia (HP:0001746)1.71111709
149Stereotypic behavior (HP:0000733)1.70842631
150Clonus (HP:0002169)1.70346090
151Gait ataxia (HP:0002066)1.70292464
152Polygenic inheritance (HP:0010982)1.70119892
153Menorrhagia (HP:0000132)1.70069406
154Pili torti (HP:0003777)1.69130913
155Bradykinesia (HP:0002067)1.68610354
156Abnormality of the fovea (HP:0000493)1.67798329
157Dyschromatopsia (HP:0007641)1.67635216
158Hamartoma of the eye (HP:0010568)1.67453282
159Ankyloglossia (HP:0010296)1.66973697
160Long nose (HP:0003189)1.66273453
161Congenital hepatic fibrosis (HP:0002612)1.66130385
162Abnormality of alanine metabolism (HP:0010916)1.65621739
163Hyperalaninemia (HP:0003348)1.65621739
164Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.65621739
165Palmoplantar hyperkeratosis (HP:0000972)1.64738788
166Aplasia/Hypoplasia of the hallux (HP:0008362)1.64490734
167Poor eye contact (HP:0000817)1.64194258
168Torticollis (HP:0000473)1.63676020
169Neonatal short-limb short stature (HP:0008921)1.61997906
170Impaired vibratory sensation (HP:0002495)1.57923869

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.40408087
2EPHA44.60541669
3LMTK23.96267427
4PRKD33.47974998
5NTRK23.41491660
6NTRK33.04576998
7TRIB32.91848736
8PHKG22.69165526
9PHKG12.69165526
10TYRO32.57362189
11MUSK2.28171826
12MAP3K92.20741251
13TNIK2.16830768
14MINK12.03790681
15ADRBK21.99685330
16MAP3K41.99411465
17PAK61.98979559
18BMPR1B1.77691899
19NTRK11.75646156
20MST41.75225237
21DAPK21.72735611
22RIPK11.72397563
23CAMKK11.70596736
24ACVR1B1.69058906
25OXSR11.61953457
26STK381.53170685
27TAOK31.53094263
28MARK11.51605357
29WNK31.48081528
30KSR21.45717239
31TNK21.43999740
32PKN11.41900606
33SGK2231.35024989
34SGK4941.35024989
35MAPKAPK31.33470932
36CDK51.29387327
37MAP2K71.28680336
38SGK21.26036800
39GRK11.22935359
40NUAK11.22580279
41ZAK1.22464847
42STK391.18093549
43SGK31.16622886
44PDK31.11836920
45PDK41.11836920
46INSRR1.11532588
47PINK11.08972196
48PRKCG1.08680225
49PRPF4B1.05858140
50MAP3K21.04794024
51WNK11.02288159
52MAP2K41.01503691
53MAPK130.97516515
54PRKCH0.97411727
55SIK10.96925972
56CSNK1G20.84670061
57PNCK0.83188157
58CAMKK20.80447860
59WNK40.79554302
60CAMK2B0.79285608
61DYRK1A0.79170987
62ERBB20.79115857
63CDK150.78774890
64FER0.77602239
65DMPK0.77196203
66KSR10.75210120
67CDK180.75118118
68BMX0.74675799
69RET0.74630915
70CDC42BPA0.74577698
71MAPK150.73990834
72RIPK40.73633524
73PAK30.73192362
74FGFR20.72771180
75TLK10.72525095
76CCNB10.72486914
77SIK20.72158696
78EIF2AK10.71872806
79MAPK120.71750757
80GRK50.71062261
81TEC0.69238111
82STK110.68670598
83CDK11A0.68014680
84CDK140.67998535
85CDK190.66839592
86FGFR10.66329444
87CSNK1G10.65725093
88STK38L0.65343742
89UHMK10.65272805
90ROCK20.63419648
91CAMK10.63031846
92PIK3CG0.62774976
93ROCK10.62677985
94FES0.62133724
95LATS20.61565149
96DYRK20.60773638
97MAPKAPK50.60744930
98PDGFRA0.60611784
99SGK10.59964387
100CSNK1G30.59564744
101ICK0.59253215
102TAOK10.59179808
103CAMK2A0.58874671
104STK160.57870746
105PLK20.57711080
106PRKCQ0.57642207
107PTK60.57343175
108CASK0.57108554
109RPS6KA30.55573661
110PLK40.55566988
111CSNK1A1L0.55166982
112ALK0.53242106
113PRKACA0.53131008
114DDR20.52695422
115PDK10.52686746
116LIMK10.52612119
117TESK10.52082795
118PTK2B0.51992333
119CAMK1G0.51945559
120PDPK10.51462333
121CAMK2D0.51433291
122DAPK10.50621974
123MAP4K20.50599247
124PRKG10.49776886
125CSNK1D0.49274592
126NEK60.48249452
127SYK0.47907212
128EPHA30.47835451
129BMPR20.47311091
130PRKCE0.45360284
131MAP3K130.44969750
132PDK20.42067143
133PRKD10.41786630
134CAMK2G0.40802833
135MKNK20.40792215
136FYN0.39957619
137PRKD20.39897709
138IRAK10.39706132
139CSNK1A10.39464752
140MAP2K10.38893786
141SRC0.38574013
142PBK0.37091321
143MAP3K120.36350467
144ADRBK10.35892612
145MARK20.35820952
146FGR0.35207218
147PRKCA0.34870747
148MAPK100.34227058

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009104.97897930
2Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.75904426
3Nicotine addiction_Homo sapiens_hsa050332.72302006
4Phototransduction_Homo sapiens_hsa047442.52820870
5Glutamatergic synapse_Homo sapiens_hsa047242.30647564
6GABAergic synapse_Homo sapiens_hsa047272.20858514
7Salivary secretion_Homo sapiens_hsa049702.14538740
8Circadian entrainment_Homo sapiens_hsa047132.11107428
9alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.09278951
10Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.06307201
11Gastric acid secretion_Homo sapiens_hsa049712.02660192
12Olfactory transduction_Homo sapiens_hsa047402.01518800
13Synaptic vesicle cycle_Homo sapiens_hsa047212.00327408
14Long-term potentiation_Homo sapiens_hsa047201.99629820
15Aldosterone synthesis and secretion_Homo sapiens_hsa049251.96720854
16Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.84762500
17Morphine addiction_Homo sapiens_hsa050321.84252949
18Linoleic acid metabolism_Homo sapiens_hsa005911.81364772
19Amphetamine addiction_Homo sapiens_hsa050311.69161087
20Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.68435760
21Insulin secretion_Homo sapiens_hsa049111.67064822
22* Fatty acid biosynthesis_Homo sapiens_hsa000611.63827659
23Histidine metabolism_Homo sapiens_hsa003401.54287271
24beta-Alanine metabolism_Homo sapiens_hsa004101.48979313
25Collecting duct acid secretion_Homo sapiens_hsa049661.47549742
26Renin secretion_Homo sapiens_hsa049241.46956406
27Primary bile acid biosynthesis_Homo sapiens_hsa001201.46009259
28Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.43627261
29Calcium signaling pathway_Homo sapiens_hsa040201.41157204
30Dopaminergic synapse_Homo sapiens_hsa047281.40811061
31Cocaine addiction_Homo sapiens_hsa050301.40575485
32Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.38598058
33Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.36369425
34Dorso-ventral axis formation_Homo sapiens_hsa043201.34799975
35Long-term depression_Homo sapiens_hsa047301.32262923
36cAMP signaling pathway_Homo sapiens_hsa040241.30777785
37Cholinergic synapse_Homo sapiens_hsa047251.27590188
38ABC transporters_Homo sapiens_hsa020101.25894822
39Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.23223725
40Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.20900265
41Oxytocin signaling pathway_Homo sapiens_hsa049211.18819732
42Taste transduction_Homo sapiens_hsa047421.18759628
43Ovarian steroidogenesis_Homo sapiens_hsa049131.18351153
44Ether lipid metabolism_Homo sapiens_hsa005651.11777052
45Gap junction_Homo sapiens_hsa045401.10252694
46Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.09694871
47GnRH signaling pathway_Homo sapiens_hsa049121.08241341
48* Fatty acid metabolism_Homo sapiens_hsa012121.08117075
49SNARE interactions in vesicular transport_Homo sapiens_hsa041301.07864476
50Phospholipase D signaling pathway_Homo sapiens_hsa040721.06711070
51Arachidonic acid metabolism_Homo sapiens_hsa005901.05401591
52Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.04371683
53Pancreatic secretion_Homo sapiens_hsa049721.01226519
54Melanogenesis_Homo sapiens_hsa049161.00705081
55Bile secretion_Homo sapiens_hsa049760.99870392
56Estrogen signaling pathway_Homo sapiens_hsa049150.99546376
57Phosphatidylinositol signaling system_Homo sapiens_hsa040700.98679115
58Circadian rhythm_Homo sapiens_hsa047100.96871417
59Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.96535293
60Serotonergic synapse_Homo sapiens_hsa047260.94064071
61Tryptophan metabolism_Homo sapiens_hsa003800.93984302
62Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.93614808
63Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.92992983
64Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.92471758
65cGMP-PKG signaling pathway_Homo sapiens_hsa040220.90528529
66Carbohydrate digestion and absorption_Homo sapiens_hsa049730.90527846
67Regulation of autophagy_Homo sapiens_hsa041400.90388254
68Thyroid hormone signaling pathway_Homo sapiens_hsa049190.90247617
69Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.88468850
70Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.87646139
71Caffeine metabolism_Homo sapiens_hsa002320.87199730
72Axon guidance_Homo sapiens_hsa043600.86754144
73Glioma_Homo sapiens_hsa052140.85125908
74Platelet activation_Homo sapiens_hsa046110.82843776
75Chemical carcinogenesis_Homo sapiens_hsa052040.81325591
76Thyroid hormone synthesis_Homo sapiens_hsa049180.79999166
77Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.78428087
78Mineral absorption_Homo sapiens_hsa049780.78203838
79Homologous recombination_Homo sapiens_hsa034400.77250012
80Sphingolipid signaling pathway_Homo sapiens_hsa040710.75439364
81Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.75230912
82Vascular smooth muscle contraction_Homo sapiens_hsa042700.73844790
83Retinol metabolism_Homo sapiens_hsa008300.73355907
84ErbB signaling pathway_Homo sapiens_hsa040120.71252280
85Steroid hormone biosynthesis_Homo sapiens_hsa001400.71017189
86Hedgehog signaling pathway_Homo sapiens_hsa043400.69724129
87Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.69291381
88Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.65003495
89Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.64764110
90Arginine and proline metabolism_Homo sapiens_hsa003300.63579050
91Glucagon signaling pathway_Homo sapiens_hsa049220.63152880
92Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.63098032
93Peroxisome_Homo sapiens_hsa041460.62824642
94Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.61603198
95Dilated cardiomyopathy_Homo sapiens_hsa054140.58439288
96Steroid biosynthesis_Homo sapiens_hsa001000.58295312
97Rap1 signaling pathway_Homo sapiens_hsa040150.57914550
98Alcoholism_Homo sapiens_hsa050340.57409067
99Choline metabolism in cancer_Homo sapiens_hsa052310.57225625
100Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.56929598
101Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.56873733
102Type II diabetes mellitus_Homo sapiens_hsa049300.56301554
103Glycerophospholipid metabolism_Homo sapiens_hsa005640.56101298
104VEGF signaling pathway_Homo sapiens_hsa043700.55707313
105Fatty acid elongation_Homo sapiens_hsa000620.55053956
106Cardiac muscle contraction_Homo sapiens_hsa042600.53228884
107Neurotrophin signaling pathway_Homo sapiens_hsa047220.48637901
108Basal cell carcinoma_Homo sapiens_hsa052170.48595948
109Inositol phosphate metabolism_Homo sapiens_hsa005620.46117170
110Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.46084033
111Wnt signaling pathway_Homo sapiens_hsa043100.45883803
112Oocyte meiosis_Homo sapiens_hsa041140.44785458
113Endocytosis_Homo sapiens_hsa041440.44249046
114MAPK signaling pathway_Homo sapiens_hsa040100.40495938
115Ras signaling pathway_Homo sapiens_hsa040140.40354265
116Glycerolipid metabolism_Homo sapiens_hsa005610.38363769
117Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.38224606
118Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.37917715
119Endometrial cancer_Homo sapiens_hsa052130.36003017
120* PPAR signaling pathway_Homo sapiens_hsa033200.35485835
121Vitamin B6 metabolism_Homo sapiens_hsa007500.34126928
122Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.33612982
123Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.33357456
124Proteoglycans in cancer_Homo sapiens_hsa052050.33219842
125Hippo signaling pathway_Homo sapiens_hsa043900.32296465
126Insulin signaling pathway_Homo sapiens_hsa049100.31562485
127Central carbon metabolism in cancer_Homo sapiens_hsa052300.30931605
128Propanoate metabolism_Homo sapiens_hsa006400.30696118
129* Adipocytokine signaling pathway_Homo sapiens_hsa049200.29986434
130Sphingolipid metabolism_Homo sapiens_hsa006000.29306082
131Longevity regulating pathway - mammal_Homo sapiens_hsa042110.28321757
132Butanoate metabolism_Homo sapiens_hsa006500.27648481
133Basal transcription factors_Homo sapiens_hsa030220.26417555

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »