ACSBG2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell-cell recognition (GO:0009988)9.99244945
2axonemal dynein complex assembly (GO:0070286)9.71648627
3motile cilium assembly (GO:0044458)9.59539938
4epithelial cilium movement (GO:0003351)9.55582102
5spermatid development (GO:0007286)9.48845318
6plasma membrane fusion (GO:0045026)9.45690946
7regulation of cilium movement (GO:0003352)9.06601750
8reproduction (GO:0000003)8.97347496
9cilium or flagellum-dependent cell motility (GO:0001539)8.75488040
10cilium movement (GO:0003341)7.81225824
11protein targeting to Golgi (GO:0000042)7.58272626
12microtubule depolymerization (GO:0007019)7.40859900
13rRNA methylation (GO:0031167)7.36057967
14epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.28383691
15establishment of protein localization to Golgi (GO:0072600)7.27913876
16phosphatidylethanolamine biosynthetic process (GO:0006646)7.24120260
17single fertilization (GO:0007338)7.19889309
18retrograde transport, vesicle recycling within Golgi (GO:0000301)7.08496997
19sperm capacitation (GO:0048240)6.93194101
20piRNA metabolic process (GO:0034587)6.86897012
21synaptonemal complex organization (GO:0070193)6.82768588
22male meiosis (GO:0007140)6.77358416
23response to pheromone (GO:0019236)6.71846048
24phosphatidylethanolamine metabolic process (GO:0046337)6.69550051
25synaptonemal complex assembly (GO:0007130)6.67838742
26* spermatogenesis (GO:0007283)6.65350350
27* male gamete generation (GO:0048232)6.63306416
28negative regulation of inclusion body assembly (GO:0090084)6.61807603
29organic cation transport (GO:0015695)6.43430383
30rRNA modification (GO:0000154)6.20361222
31* gamete generation (GO:0007276)6.09056008
32fertilization (GO:0009566)6.06148117
33centriole replication (GO:0007099)5.99506129
34calcium ion-dependent exocytosis (GO:0017156)5.58723445
35regulation of inclusion body assembly (GO:0090083)5.56012863
36protein localization to Golgi apparatus (GO:0034067)5.48654818
37germ cell development (GO:0007281)5.27975934
38cellular process involved in reproduction in multicellular organism (GO:0022412)5.19809853
39regulation of microtubule-based movement (GO:0060632)5.10154945
40microtubule severing (GO:0051013)5.03924342
41chromosome condensation (GO:0030261)5.03814774
42ventricular system development (GO:0021591)4.96509493
43DNA packaging (GO:0006323)4.95498745
44cellular ketone body metabolic process (GO:0046950)4.94033688
45regulation of centriole replication (GO:0046599)4.92457450
46DNA methylation involved in gamete generation (GO:0043046)4.88814489
47cell recognition (GO:0008037)4.86512812
48male meiosis I (GO:0007141)4.78178876
49* multicellular organismal reproductive process (GO:0048609)4.76677504
50positive regulation of Rab GTPase activity (GO:0032851)4.72089854
51regulation of Rab GTPase activity (GO:0032313)4.72089854
52chromosome organization involved in meiosis (GO:0070192)4.69415163
53spermatid nucleus differentiation (GO:0007289)4.68644590
54seminiferous tubule development (GO:0072520)4.56224473
55glycerol ether metabolic process (GO:0006662)4.56126236
56regulation of transcription involved in cell fate commitment (GO:0060850)4.53932742
57ketone body metabolic process (GO:1902224)4.35033411
58ether metabolic process (GO:0018904)4.23193610
59multicellular organismal movement (GO:0050879)4.11008094
60musculoskeletal movement (GO:0050881)4.11008094
61left/right pattern formation (GO:0060972)4.09434770
62meiotic nuclear division (GO:0007126)4.09114572
63single strand break repair (GO:0000012)4.02449900
64meiosis I (GO:0007127)3.84502374
65* multicellular organismal development (GO:0007275)3.82620930
66regulation of spindle checkpoint (GO:0090231)3.81346768
67microtubule nucleation (GO:0007020)3.79484215
68protein polyglutamylation (GO:0018095)3.73902477
69sequestering of actin monomers (GO:0042989)3.72227241
70microtubule polymerization or depolymerization (GO:0031109)3.67039872
71membrane protein intracellular domain proteolysis (GO:0031293)3.64435283
72response to acidic pH (GO:0010447)3.59138758
73protein localization to cilium (GO:0061512)3.53972065
74glomerular visceral epithelial cell development (GO:0072015)3.49707283
75protein K11-linked deubiquitination (GO:0035871)3.46181339
76nucleosome disassembly (GO:0006337)3.43523723
77protein-DNA complex disassembly (GO:0032986)3.43523723
78cellular response to pH (GO:0071467)3.42718759
79meiotic cell cycle (GO:0051321)3.38728492
80nuclear pore complex assembly (GO:0051292)3.38621951
81chaperone-mediated protein complex assembly (GO:0051131)3.37314104
82glomerular epithelial cell development (GO:0072310)3.36057585
83regulation of somitogenesis (GO:0014807)3.35737696
84sexual reproduction (GO:0019953)3.33671102
85homeostasis of number of cells within a tissue (GO:0048873)3.29735770
86RNA localization (GO:0006403)3.28599701
87nucleus organization (GO:0006997)3.27798250
88cerebral cortex neuron differentiation (GO:0021895)3.26148406
89peptidyl-threonine dephosphorylation (GO:0035970)3.22407518
90regulation of interleukin-13 production (GO:0032656)3.19851979
91negative regulation of Rho protein signal transduction (GO:0035024)3.18517523
92protein refolding (GO:0042026)3.17238849
93RNA destabilization (GO:0050779)3.16709172
94cilium organization (GO:0044782)3.16617917
95nucleoside diphosphate phosphorylation (GO:0006165)3.15235254
96mitochondrial fission (GO:0000266)3.12978191
97cilium assembly (GO:0042384)3.09181555
98polyol catabolic process (GO:0046174)3.06971907
99centriole assembly (GO:0098534)3.03025633
100monoubiquitinated protein deubiquitination (GO:0035520)3.02182937
101coenzyme catabolic process (GO:0009109)2.99185362
102polyamine biosynthetic process (GO:0006596)2.98842102
103interferon-gamma secretion (GO:0072643)2.97562933
104synapsis (GO:0007129)2.97552964
105positive regulation of guanylate cyclase activity (GO:0031284)2.96503633
106intraciliary transport (GO:0042073)2.96419634
107regulation of phosphoprotein phosphatase activity (GO:0043666)2.96249961
108cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.95829497
109regulation of T-helper 2 cell differentiation (GO:0045628)2.94365224
110intra-Golgi vesicle-mediated transport (GO:0006891)2.94083280
111meiotic cell cycle process (GO:1903046)2.93935064
112axoneme assembly (GO:0035082)2.93693747
113histone H3-K9 demethylation (GO:0033169)2.92949710
114DNA conformation change (GO:0071103)2.92159505
115Golgi to endosome transport (GO:0006895)2.92155727
116genitalia morphogenesis (GO:0035112)2.91810042
117mitotic sister chromatid cohesion (GO:0007064)2.90727716
118mitotic G1 DNA damage checkpoint (GO:0031571)2.90578102
119cellular component assembly involved in morphogenesis (GO:0010927)2.88237405
120vesicle transport along microtubule (GO:0047496)2.85151341
121centrosome duplication (GO:0051298)2.83002739
122positive regulation of macrophage activation (GO:0043032)2.81362041
123regulation of guanylate cyclase activity (GO:0031282)2.79968739
124GTP biosynthetic process (GO:0006183)2.77959235
125cilium morphogenesis (GO:0060271)2.76909372
126negative regulation of skeletal muscle tissue development (GO:0048642)2.69609729
127glycolytic process (GO:0006096)2.69242510
128microtubule-based movement (GO:0007018)2.59076459
129alditol metabolic process (GO:0019400)2.57553639
130mitochondrion degradation (GO:0000422)2.44001397
131lactate metabolic process (GO:0006089)2.42055729
132UTP biosynthetic process (GO:0006228)2.40538109
133regulation of cilium assembly (GO:1902017)2.39668219
134carnitine transport (GO:0015879)2.37709264
135amino-acid betaine transport (GO:0015838)2.37709264
136protein depolymerization (GO:0051261)2.37133395
137calcium ion import (GO:0070509)2.34961292
138chromatin silencing (GO:0006342)2.29530654
139sperm motility (GO:0030317)13.5063204
140fusion of sperm to egg plasma membrane (GO:0007342)12.3885502
141acrosome reaction (GO:0007340)12.3133988
142cell wall macromolecule metabolic process (GO:0044036)12.2104016
143cell wall macromolecule catabolic process (GO:0016998)12.2104016
144sperm-egg recognition (GO:0035036)11.2008764
145acrosome assembly (GO:0001675)11.0733999
146multicellular organism reproduction (GO:0032504)10.5839789
147binding of sperm to zona pellucida (GO:0007339)10.0898350

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse8.25291284
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.43859032
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.37990508
4EZH2_22144423_ChIP-Seq_EOC_Human4.27058037
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.26057302
6MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.38867359
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.22792533
8BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.01519428
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.74105399
10PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.61296056
11VDR_22108803_ChIP-Seq_LS180_Human2.60293834
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.58970621
13PCGF2_27294783_Chip-Seq_ESCs_Mouse2.32305383
14GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.30651352
15CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.25355103
16VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.17766620
17CTBP1_25329375_ChIP-Seq_LNCAP_Human2.14095322
18GATA1_26923725_Chip-Seq_HPCs_Mouse2.03941249
19DROSHA_22980978_ChIP-Seq_HELA_Human2.01169023
20EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.93307307
21ELF1_20517297_ChIP-Seq_JURKAT_Human1.93156146
22CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.86584952
23RAC3_21632823_ChIP-Seq_H3396_Human1.83526742
24KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.78401633
25MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.77828134
26STAT1_17558387_ChIP-Seq_HELA_Human1.76653636
27CTCF_27219007_Chip-Seq_Bcells_Human1.76315715
28ERA_21632823_ChIP-Seq_H3396_Human1.75385584
29EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.75144615
30NANOG_20526341_ChIP-Seq_ESCs_Human1.75021109
31RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.74514647
32NFE2_27457419_Chip-Seq_LIVER_Mouse1.72302222
33ELK4_26923725_Chip-Seq_MESODERM_Mouse1.71347359
34EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.65802037
35PCGF2_27294783_Chip-Seq_NPCs_Mouse1.65551200
36MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.63497905
37SUZ12_27294783_Chip-Seq_NPCs_Mouse1.62636983
38TAF2_19829295_ChIP-Seq_ESCs_Human1.60012668
39UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.57822737
40ZNF274_21170338_ChIP-Seq_K562_Hela1.57176237
41STAT6_21828071_ChIP-Seq_BEAS2B_Human1.57160656
42BCL6_27268052_Chip-Seq_Bcells_Human1.57101647
43YY1_22570637_ChIP-Seq_MALME-3M_Human1.54923919
44TDRD3_21172665_ChIP-Seq_MCF-7_Human1.54340552
45* TAL1_26923725_Chip-Seq_HPCs_Mouse1.53330759
46TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.52489811
47SMC4_20622854_ChIP-Seq_HELA_Human1.52243586
48* KAP1_22055183_ChIP-Seq_ESCs_Mouse1.51763810
49TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.51503193
50CBX2_27304074_Chip-Seq_ESCs_Mouse1.51322524
51ARNT_22903824_ChIP-Seq_MCF-7_Human1.50731224
52GATA3_21867929_ChIP-Seq_CD8_Mouse1.49569070
53MYC_19829295_ChIP-Seq_ESCs_Human1.49447033
54SMAD4_21741376_ChIP-Seq_EPCs_Human1.48643620
55BCOR_27268052_Chip-Seq_Bcells_Human1.47800209
56ER_23166858_ChIP-Seq_MCF-7_Human1.47662023
57ZFP57_27257070_Chip-Seq_ESCs_Mouse1.47070611
58KDM2B_26808549_Chip-Seq_REH_Human1.45559438
59AR_25329375_ChIP-Seq_VCAP_Human1.45432992
60PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.45134618
61* SOX2_22085726_ChIP-Seq_NPCs_Mouse1.44875792
62WDR5_24793694_ChIP-Seq_LNCAP_Human1.44834329
63OCT4_20526341_ChIP-Seq_ESCs_Human1.42866215
64PHF8_20622854_ChIP-Seq_HELA_Human1.42629438
65RBPJ_21746931_ChIP-Seq_IB4_Human1.42437119
66NANOG_18555785_Chip-Seq_ESCs_Mouse1.41476569
67FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.41316749
68E2F1_20622854_ChIP-Seq_HELA_Human1.41129951
69P68_20966046_ChIP-Seq_HELA_Human1.40920448
70CBX2_22325352_ChIP-Seq_293T-Rex_Human1.40092479
71RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.39962724
72HNFA_21074721_ChIP-Seq_CACO-2_Human1.39890501
73CTCF_20526341_ChIP-Seq_ESCs_Human1.39816409
74REST_21632747_ChIP-Seq_MESCs_Mouse1.39422148
75CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.38386791
76TP63_22573176_ChIP-Seq_HFKS_Human1.38339031
77ETV1_20927104_ChIP-Seq_GIST48_Human1.33820977
78ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.33761350
79ETV2_25802403_ChIP-Seq_MESCs_Mouse1.32979497
80ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.32252556
81SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.32029792
82P53_22387025_ChIP-Seq_ESCs_Mouse1.31792896
83TP53_18474530_ChIP-ChIP_U2OS_Human1.31273618
84TP63_19390658_ChIP-ChIP_HaCaT_Human1.30200055
85SMAD3_21741376_ChIP-Seq_ESCs_Human1.29977168
86PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.29416436
87SMAD3_21741376_ChIP-Seq_EPCs_Human1.28858391
88FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.28757006
89TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28621117
90POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.28621117
91LXR_22292898_ChIP-Seq_THP-1_Human1.28461617
92P300_27268052_Chip-Seq_Bcells_Human1.28174120
93IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.28001865
94CBP_20019798_ChIP-Seq_JUKART_Human1.28001865
95GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.27850694
96CEBPB_22108803_ChIP-Seq_LS180_Human1.26105565
97EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.26072827
98TAF15_26573619_Chip-Seq_HEK293_Human1.25732874
99P300_19829295_ChIP-Seq_ESCs_Human1.25586564
100CTBP2_25329375_ChIP-Seq_LNCAP_Human1.24993407
101OCT4_18555785_Chip-Seq_ESCs_Mouse1.24816741
102* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.24731916
103EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.24652306
104PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.24560320
105CRX_20693478_ChIP-Seq_RETINA_Mouse1.24211623
106NFYB_21822215_ChIP-Seq_K562_Human1.24162216
107GATA3_21867929_ChIP-Seq_TH1_Mouse1.24066800
108EZH2_27294783_Chip-Seq_NPCs_Mouse1.23975929
109P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.22949375
110KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.22925600
111SUZ12_27294783_Chip-Seq_ESCs_Mouse1.22828892
112* GF1_26923725_Chip-Seq_HPCs_Mouse1.21968926
113CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.20316835
114TBL1_22424771_ChIP-Seq_293T_Human1.19608642
115CMYC_18555785_Chip-Seq_ESCs_Mouse1.19509846
116* AUTS2_25519132_ChIP-Seq_293T-REX_Human1.19328213
117SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.18450078
118LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.18133657
119RNF2_27304074_Chip-Seq_NSC_Mouse1.17676897
120TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17653363
121DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.17608640
122SUZ12_18555785_Chip-Seq_ESCs_Mouse1.17199344
123P300_18555785_Chip-Seq_ESCs_Mouse1.16137843
124RBPJ_22232070_ChIP-Seq_NCS_Mouse1.15882364
125PHF8_20622853_ChIP-Seq_HELA_Human1.14534746
126EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.13866457
127KLF4_18555785_Chip-Seq_ESCs_Mouse1.13789963
128STAT3_18555785_Chip-Seq_ESCs_Mouse1.13402333
129ESRRB_18555785_Chip-Seq_ESCs_Mouse1.13353965
130GATA3_21878914_ChIP-Seq_MCF-7_Human1.13306588
131GATA6_21074721_ChIP-Seq_CACO-2_Human1.13155079
132TOP2B_26459242_ChIP-Seq_MCF-7_Human1.13022563
133FLI1_21867929_ChIP-Seq_TH2_Mouse1.12320853
134* SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.12171708
135MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.11741749
136OCT4_21477851_ChIP-Seq_ESCs_Mouse1.11527330
137SMAD4_21799915_ChIP-Seq_A2780_Human1.10653537
138SMRT_27268052_Chip-Seq_Bcells_Human1.10195090
139E2F1_18555785_Chip-Seq_ESCs_Mouse1.09449063
140SPI1_26923725_Chip-Seq_HPCs_Mouse1.09290370
141* CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.08065428
142SOX2_18555785_Chip-Seq_ESCs_Mouse1.06845518
143PU1_27457419_Chip-Seq_LIVER_Mouse1.06835070
144P53_21459846_ChIP-Seq_SAOS-2_Human1.06347551
145* RUNX1_26923725_Chip-Seq_HPCs_Mouse1.06225136
146SMAD4_21741376_ChIP-Seq_HESCs_Human1.05916481
147TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.05612321
148NFYA_21822215_ChIP-Seq_K562_Human1.05411822
149STAT3_18555785_ChIP-Seq_MESCs_Mouse1.04640692
150RAD21_21589869_ChIP-Seq_MESCs_Mouse1.04421558
151PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.04308270
152EZH2_27294783_Chip-Seq_ESCs_Mouse1.04213577
153GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.03779203
154SA1_27219007_Chip-Seq_Bcells_Human1.03611571
155FUS_26573619_Chip-Seq_HEK293_Human1.02616222
156NANOG_19829295_ChIP-Seq_ESCs_Human1.02600302
157SOX2_19829295_ChIP-Seq_ESCs_Human1.02600302
158NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.02018575
159PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.01912387
160PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00933254
161NMYC_18555785_Chip-Seq_ESCs_Mouse1.00296690
162KLF5_20875108_ChIP-Seq_MESCs_Mouse1.00250967
163RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.00095192
164SOX9_26525672_Chip-Seq_HEART_Mouse1.00002316
165KLF5_25053715_ChIP-Seq_YYC3_Human0.99042059
166OCT1_27270436_Chip-Seq_PROSTATE_Human0.98994151
167* STAT3_23295773_ChIP-Seq_U87_Human0.98609276
168* CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98278174
169ZFX_18555785_Chip-Seq_ESCs_Mouse0.98042684
170PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97421439
171RUNX1_27457419_Chip-Seq_LIVER_Mouse0.96906733
172CTCF_18555785_Chip-Seq_ESCs_Mouse0.95722349
173* RXRA_24833708_ChIP-Seq_LIVER_Mouse0.94725580
174SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.94032071
175LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.93217090
176ERG_20517297_ChIP-Seq_VCAP_Human0.92461558
177SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.92010060
178* CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.91189501

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.76212832
2MP0001929_abnormal_gametogenesis5.22051400
3MP0008877_abnormal_DNA_methylation4.09483999
4MP0002210_abnormal_sex_determination3.35804526
5MP0005670_abnormal_white_adipose3.11077892
6MP0002161_abnormal_fertility/fecundity3.10761349
7MP0001348_abnormal_lacrimal_gland2.92396030
8MP0001145_abnormal_male_reproductive2.74801139
9MP0000653_abnormal_sex_gland2.40936111
10MP0002653_abnormal_ependyma_morphology2.28320497
11MP0003718_maternal_effect2.21723837
12MP0000678_abnormal_parathyroid_gland2.02280420
13MP0002160_abnormal_reproductive_system2.00678984
14MP0005410_abnormal_fertilization15.4256697
15MP0001485_abnormal_pinna_reflex1.79438148
16MP0001984_abnormal_olfaction1.76713267
17MP0008058_abnormal_DNA_repair1.63558557
18MP0005451_abnormal_body_composition1.61384500
19MP0003646_muscle_fatigue1.61150817
20MP0005310_abnormal_salivary_gland1.59809098
21MP0001486_abnormal_startle_reflex1.46586175
22MP0002822_catalepsy1.43563438
23MP0002249_abnormal_larynx_morphology1.38125228
24MP0004859_abnormal_synaptic_plasticity1.28738609
25MP0009697_abnormal_copulation1.24859523
26MP0002132_abnormal_respiratory_system1.20655735
27MP0005389_reproductive_system_phenotype1.17754957
28MP0009053_abnormal_anal_canal1.16002976
29MP0003787_abnormal_imprinting1.10918052
30MP0008995_early_reproductive_senescence1.08695156
31MP0002138_abnormal_hepatobiliary_system1.06090397
32MP0005647_abnormal_sex_gland1.05484706
33MP0005623_abnormal_meninges_morphology1.02693725
34MP0005395_other_phenotype0.99118361
35MP0010094_abnormal_chromosome_stability0.97624558
36MP0005666_abnormal_adipose_tissue0.96595598
37MP0000566_synostosis0.96164671
38MP0000026_abnormal_inner_ear0.96112128
39MP0000955_abnormal_spinal_cord0.92671095
40MP0002102_abnormal_ear_morphology0.91848031
41MP0008057_abnormal_DNA_replication0.91752459
42MP0002282_abnormal_trachea_morphology0.90467027
43MP0002127_abnormal_cardiovascular_syste0.89675025
44MP0009046_muscle_twitch0.89054807
45MP0002229_neurodegeneration0.88852417
46MP0001986_abnormal_taste_sensitivity0.87722350
47MP0005646_abnormal_pituitary_gland0.87212099
48MP0005248_abnormal_Harderian_gland0.85633428
49MP0002736_abnormal_nociception_after0.85001391
50MP0002163_abnormal_gland_morphology0.84042030
51MP0001765_abnormal_ion_homeostasis0.80651689
52MP0003111_abnormal_nucleus_morphology0.79840253
53MP0005377_hearing/vestibular/ear_phenot0.79724544
54MP0003878_abnormal_ear_physiology0.79724544
55MP0001293_anophthalmia0.78977366
56MP0008569_lethality_at_weaning0.78389955
57MP0002277_abnormal_respiratory_mucosa0.77077818
58MP0000569_abnormal_digit_pigmentation0.76733991
59MP0002067_abnormal_sensory_capabilities0.76544855
60MP0004233_abnormal_muscle_weight0.75324107
61MP0001905_abnormal_dopamine_level0.73192929
62MP0005083_abnormal_biliary_tract0.70399837
63MP0005423_abnormal_somatic_nervous0.69431871
64MP0000681_abnormal_thyroid_gland0.68382406
65MP0004510_myositis0.67914248
66MP0005375_adipose_tissue_phenotype0.67803234
67MP0003786_premature_aging0.65279637
68MP0001119_abnormal_female_reproductive0.65006307
69MP0004085_abnormal_heartbeat0.61754185
70MP0002234_abnormal_pharynx_morphology0.60947135
71MP0003115_abnormal_respiratory_system0.57122120
72MP0003699_abnormal_female_reproductive0.56408511
73MP0001324_abnormal_eye_pigmentation0.55675266
74MP0006292_abnormal_olfactory_placode0.55600383
75MP0001666_abnormal_nutrient_absorption0.55129648
76MP0002272_abnormal_nervous_system0.54983433
77MP0000015_abnormal_ear_pigmentation0.53834235
78MP0005167_abnormal_blood-brain_barrier0.52323504
79MP0001968_abnormal_touch/_nociception0.50762286
80MP0001764_abnormal_homeostasis0.50568798
81MP0001879_abnormal_lymphatic_vessel0.50297600
82MP0010329_abnormal_lipoprotein_level0.50154078
83MP0009745_abnormal_behavioral_response0.49946494
84MP0002733_abnormal_thermal_nociception0.48174073
85MP0005253_abnormal_eye_physiology0.48143959
86MP0008007_abnormal_cellular_replicative0.47923005
87MP0001919_abnormal_reproductive_system0.47594077
88MP0004742_abnormal_vestibular_system0.47443791
89MP0003137_abnormal_impulse_conducting0.46420670
90MP0000613_abnormal_salivary_gland0.46148346
91MP0005499_abnormal_olfactory_system0.46129645
92MP0005394_taste/olfaction_phenotype0.46129645
93MP0001440_abnormal_grooming_behavior0.46120108
94MP0005379_endocrine/exocrine_gland_phen0.45417461
95MP0004484_altered_response_of0.45316878
96MP0008961_abnormal_basal_metabolism0.44862965
97MP0005397_hematopoietic_system_phenotyp0.44318828
98MP0001545_abnormal_hematopoietic_system0.44318828
99MP0005367_renal/urinary_system_phenotyp0.44289968
100MP0000516_abnormal_urinary_system0.44289968
101MP0003631_nervous_system_phenotype0.43257628
102MP0002734_abnormal_mechanical_nocicepti0.42604265
103MP0004133_heterotaxia0.42503657
104MP0008789_abnormal_olfactory_epithelium0.42403238
105MP0000003_abnormal_adipose_tissue0.42367389
106MP0010386_abnormal_urinary_bladder0.42307304
107MP0002876_abnormal_thyroid_physiology0.42041676
108MP0001835_abnormal_antigen_presentation0.41754029
109MP0000230_abnormal_systemic_arterial0.41702459
110MP0005551_abnormal_eye_electrophysiolog0.41474174
111MP0003879_abnormal_hair_cell0.39547257
112MP0004036_abnormal_muscle_relaxation0.39213270
113MP0003880_abnormal_central_pattern0.38488247
114MP0002638_abnormal_pupillary_reflex0.38060832
115MP0001501_abnormal_sleep_pattern0.37966448
116MP0005535_abnormal_body_temperature0.37683012
117MP0005391_vision/eye_phenotype0.36636544
118MP0003632_abnormal_nervous_system0.36125402
119MP0000249_abnormal_blood_vessel0.35451879
120MP0001188_hyperpigmentation0.35404042
121MP0003635_abnormal_synaptic_transmissio0.34242125
122MP0001970_abnormal_pain_threshold0.33779955
123MP0009115_abnormal_fat_cell0.33641181
124MP0002735_abnormal_chemical_nociception0.33430037
125MP0005636_abnormal_mineral_homeostasis0.32901737
126MP0001529_abnormal_vocalization0.32685386
127MP0002882_abnormal_neuron_morphology0.32409894
128MP0002928_abnormal_bile_duct0.31802446
129MP0003633_abnormal_nervous_system0.31595685
130MP0005408_hypopigmentation0.31564879
131MP0003011_delayed_dark_adaptation0.31528370
132MP0000534_abnormal_ureter_morphology0.31119027
133MP0009278_abnormal_bone_marrow0.30951740
134MP0000470_abnormal_stomach_morphology0.30878831
135MP0005645_abnormal_hypothalamus_physiol0.30086589
136MP0003077_abnormal_cell_cycle0.28945349
137MP0002148_abnormal_hypersensitivity_rea0.27844753
138MP0000358_abnormal_cell_content/0.26948467
139MP0003861_abnormal_nervous_system0.26445399
140MP0008260_abnormal_autophagy0.26188154
141MP0009785_altered_susceptibility_to0.25903953
142MP0005174_abnormal_tail_pigmentation0.25801751
143MP0002557_abnormal_social/conspecific_i0.25249920
144MP0002572_abnormal_emotion/affect_behav0.24279820
145MP0001346_abnormal_lacrimal_gland0.23737021
146MP0005503_abnormal_tendon_morphology0.23469919
147MP0001502_abnormal_circadian_rhythm0.23310297
148MP0001270_distended_abdomen0.22521946
149MP0004811_abnormal_neuron_physiology0.22489219
150MP0003136_yellow_coat_color0.22444349
151MP0000049_abnormal_middle_ear0.21962837
152MP0001963_abnormal_hearing_physiology0.21536442
153MP0002169_no_abnormal_phenotype0.21526385
154MP0002873_normal_phenotype0.21207777
155MP0000313_abnormal_cell_death0.21175932
156MP0002405_respiratory_system_inflammati0.20803485
157MP0003948_abnormal_gas_homeostasis0.20598638

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)8.83830417
2Abnormal respiratory epithelium morphology (HP:0012253)8.81152867
3Abnormal respiratory motile cilium morphology (HP:0005938)8.81152867
4Severe visual impairment (HP:0001141)7.66382110
5Abnormal ciliary motility (HP:0012262)7.14523447
6Rhinitis (HP:0012384)6.97989010
7Chronic bronchitis (HP:0004469)6.72425023
8Infertility (HP:0000789)6.48765555
9Nasal polyposis (HP:0100582)5.45905249
10Asymmetric septal hypertrophy (HP:0001670)5.30799887
11Hyperkalemia (HP:0002153)5.12195714
12Bony spicule pigmentary retinopathy (HP:0007737)4.65566803
13Resting tremor (HP:0002322)4.61306881
14Male infertility (HP:0003251)4.61024763
15Cone-rod dystrophy (HP:0000548)4.54047345
16Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.46165214
17Abnormality of macular pigmentation (HP:0008002)4.43518350
18Abnormality of the nasal mucosa (HP:0000433)4.34849822
19Nephronophthisis (HP:0000090)4.22101051
20Bronchiectasis (HP:0002110)4.21058714
21Bronchitis (HP:0012387)4.07284335
22Hypoalphalipoproteinemia (HP:0003233)4.02631596
23Abnormal spermatogenesis (HP:0008669)3.89449915
24Hypoplasia of the thymus (HP:0000778)3.77972536
25Potter facies (HP:0002009)3.76686622
26Facial shape deformation (HP:0011334)3.76686622
27Progressive sensorineural hearing impairment (HP:0000408)3.72715892
28Menstrual irregularities (HP:0000858)3.69199964
29Aplasia/Hypoplasia of the earlobes (HP:0009906)3.63315797
30Abnormal rod and cone electroretinograms (HP:0008323)3.44481952
31Renovascular hypertension (HP:0100817)3.40432063
32Amelogenesis imperfecta (HP:0000705)3.24073655
33Truncal obesity (HP:0001956)3.22611836
34Abnormality of the renal medulla (HP:0100957)3.22298429
35Postural instability (HP:0002172)3.17058608
36Impulsivity (HP:0100710)3.11064428
37Insulin-resistant diabetes mellitus (HP:0000831)3.03782294
38Tubulointerstitial nephritis (HP:0001970)2.98442612
39Recurrent sinusitis (HP:0011108)2.98145949
40Abnormality of midbrain morphology (HP:0002418)2.94923642
41Molar tooth sign on MRI (HP:0002419)2.94923642
42Portal hypertension (HP:0001409)2.94167589
43Progressive cerebellar ataxia (HP:0002073)2.92397974
44Hypoplastic ischia (HP:0003175)2.87726363
45Recurrent otitis media (HP:0000403)2.87275951
46Enlarged epiphyses (HP:0010580)2.83081392
47Abnormality of dental color (HP:0011073)2.83034465
48Medial flaring of the eyebrow (HP:0010747)2.76968526
49Abnormality of potassium homeostasis (HP:0011042)2.73631666
50Abnormality of the hepatic vasculature (HP:0006707)2.71729883
51Abnormality of the aortic arch (HP:0012303)2.62505824
52Abnormality of the ischium (HP:0003174)2.61112322
53Dyschromatopsia (HP:0007641)2.59528104
54Generalized aminoaciduria (HP:0002909)2.56400649
55Unilateral renal agenesis (HP:0000122)2.52932104
56Azoospermia (HP:0000027)2.52589209
57Abnormality of the costochondral junction (HP:0000919)2.48683713
58Tubular atrophy (HP:0000092)2.48519888
59Hyperuricemia (HP:0002149)2.46607213
60Increased purine levels (HP:0004368)2.46607213
61Tubulointerstitial abnormality (HP:0001969)2.42338778
62Choroideremia (HP:0001139)2.37886997
63Subcapsular cataract (HP:0000523)2.36679579
64Progressive hearing impairment (HP:0001730)2.34943575
65Postaxial foot polydactyly (HP:0001830)2.33416646
66Recurrent bronchitis (HP:0002837)2.30523877
67Myokymia (HP:0002411)2.28730300
68Decreased central vision (HP:0007663)2.24879718
69Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.22017805
70Abnormality of the parathyroid morphology (HP:0011766)2.14157566
71Pancreatic fibrosis (HP:0100732)2.11860492
72Ventricular tachycardia (HP:0004756)2.11608062
73Hypoplasia of the capital femoral epiphysis (HP:0003090)2.11175712
74Gonadotropin excess (HP:0000837)2.10188525
75Abnormal biliary tract physiology (HP:0012439)2.07486565
76Bile duct proliferation (HP:0001408)2.07486565
77Congenital hepatic fibrosis (HP:0002612)2.06324081
78Osteomalacia (HP:0002749)2.04077000
79Recurrent pneumonia (HP:0006532)2.03637527
80Intellectual disability, moderate (HP:0002342)2.02570773
81Hypolipoproteinemia (HP:0010981)2.00097918
82Absent/shortened dynein arms (HP:0200106)12.6541027
83Dynein arm defect of respiratory motile cilia (HP:0012255)12.6541027
84Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.1091425
85Flattened epiphyses (HP:0003071)1.99700271
86Hypophosphatemic rickets (HP:0004912)1.98599529
87Optic neuritis (HP:0100653)1.92570037
88Retrobulbar optic neuritis (HP:0100654)1.92570037
89Widely patent fontanelles and sutures (HP:0004492)1.91903211
90Abnormality of the renal cortex (HP:0011035)1.89842826
91Abnormal drinking behavior (HP:0030082)1.89699201
92Polydipsia (HP:0001959)1.89699201
93Congenital malformation of the right heart (HP:0011723)1.89025281
94Double outlet right ventricle (HP:0001719)1.89025281
95Hyponatremia (HP:0002902)1.87311214
96True hermaphroditism (HP:0010459)1.86227325
97Focal segmental glomerulosclerosis (HP:0000097)1.84977789
98Renal Fanconi syndrome (HP:0001994)1.84086583
99Abnormality of chloride homeostasis (HP:0011422)1.83789943
100Facial cleft (HP:0002006)1.81632466
101Tubulointerstitial fibrosis (HP:0005576)1.81046147
102Insulin resistance (HP:0000855)1.80082773
103Abnormality of the epiphysis of the femoral head (HP:0010574)1.76894342
104Postaxial hand polydactyly (HP:0001162)1.75574963
105Cystic liver disease (HP:0006706)1.74717196
106Spastic tetraparesis (HP:0001285)1.74425417
107Obsessive-compulsive behavior (HP:0000722)1.74395856
108Epiphyseal dysplasia (HP:0002656)1.73756174
109Photophobia (HP:0000613)1.73264997
110Stage 5 chronic kidney disease (HP:0003774)1.72240565
111Aplasia/Hypoplasia of the lens (HP:0008063)1.71238360
112Bradycardia (HP:0001662)1.70971737
113Type 2 muscle fiber atrophy (HP:0003554)1.70723505
114Abnormal gallbladder physiology (HP:0012438)1.69629366
115Cholecystitis (HP:0001082)1.69629366
116Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.69248535
117Absent epiphyses (HP:0010577)1.69248535
118Abnormality of renal excretion (HP:0011036)1.69083706
119Tetany (HP:0001281)1.68363696
120Recurrent corneal erosions (HP:0000495)1.68290777
121Median cleft lip (HP:0000161)1.64707990
122Flat capital femoral epiphysis (HP:0003370)1.63948240
123Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.63681289
124Nephrogenic diabetes insipidus (HP:0009806)1.63367230
125Renal dysplasia (HP:0000110)1.62354582
126Congenital primary aphakia (HP:0007707)1.59722715
127Pancreatic cysts (HP:0001737)1.57961082
128Gait imbalance (HP:0002141)1.57196944
129Oculomotor apraxia (HP:0000657)1.56443415
130Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.54568756
131Abnormality of the dental root (HP:0006486)1.54332427
132Taurodontia (HP:0000679)1.54332427
133Abnormality of permanent molar morphology (HP:0011071)1.54332427
134Optic nerve hypoplasia (HP:0000609)1.52304016
135Fibular hypoplasia (HP:0003038)1.50492020
136Abnormality of molar morphology (HP:0011070)1.49941985
137Abnormality of molar (HP:0011077)1.49941985
138Supernumerary spleens (HP:0009799)1.49907305
139Aplasia/Hypoplasia of the tongue (HP:0010295)1.48792033
140Bell-shaped thorax (HP:0001591)1.48556395
141Orchitis (HP:0100796)1.48084806
142Chronic hepatic failure (HP:0100626)1.47257513
143Nephropathy (HP:0000112)1.46267970
144Occipital encephalocele (HP:0002085)1.46104698
145Hemorrhage of the eye (HP:0011885)1.45820268
146Short ribs (HP:0000773)1.45796000
147Abnormal urine output (HP:0012590)1.44829830
148Constricted visual fields (HP:0001133)1.42720235
149Easy fatigability (HP:0003388)1.42610475
150Abnormality of the dental pulp (HP:0006479)1.38925351
151Short thorax (HP:0010306)1.36365263
152Poor coordination (HP:0002370)1.34248049
153Heterotopia (HP:0002282)1.32456631
154Attenuation of retinal blood vessels (HP:0007843)1.32271177
155Polyuria (HP:0000103)1.31440129
156Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.29512163
157Decreased electroretinogram (ERG) amplitude (HP:0000654)1.29167644
158Muscle fiber atrophy (HP:0100295)1.29074842
159Lissencephaly (HP:0001339)1.27934255
160Fatigable weakness (HP:0003473)1.27890286
161Abnormality of the neuromuscular junction (HP:0003398)1.27890286
162Abnormal connection of the cardiac segments (HP:0011545)1.24926090

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK37.28143403
2PDK47.28143403
3TESK16.54387113
4PRKD35.22597229
5PDK24.91068713
6ICK4.35561220
7DDR23.76018029
8INSRR3.33788728
9PLK23.29979299
10CAMK1G2.78796401
11MAP4K22.57475466
12PTK2B2.11217901
13STK382.01660051
14PIK3CG1.79387445
15MST1R1.74092668
16PNCK1.61881395
17WNK41.55222679
18CDK121.52404605
19DYRK1B1.43085004
20NEK21.42411639
21STK391.35979609
22CCNB11.23442006
23STK38L1.22042880
24CDK71.07371977
25CAMK1D1.02934154
26PDK11.01052550
27SIK20.97818925
28IRAK10.94294152
29CHEK20.93670925
30PINK10.90193382
31MAP2K60.89000910
32DYRK30.88851767
33MAPK150.85617814
34KSR20.83451370
35AKT30.83311916
36ZAK0.82093164
37PLK40.79334572
38CASK0.76845935
39MAP3K90.75523333
40RIPK40.74325257
41TTK0.71299954
42YES10.68347440
43TXK0.67581240
44MAP3K110.65627371
45NEK60.64974387
46SIK30.64417478
47STK30.64206547
48ADRBK20.64200980
49PASK0.64039621
50MAP3K140.63659032
51BMPR1B0.61266254
52WNK10.60152894
53MAP2K70.59858234
54CAMK10.58301633
55MAP2K20.58125937
56RPS6KA20.57957550
57PDPK10.57243651
58LATS20.56846078
59ATR0.56825510
60BRSK20.56260417
61PRKCG0.55610167
62NTRK20.54190468
63UHMK10.53666684
64ROCK10.53101427
65MAP3K20.51560711
66TYRO30.50028111
67SRPK10.49485994
68BRAF0.48338475
69CHEK10.47863085
70MARK30.47334780
71IRAK20.45968236
72LATS10.45440653
73MUSK0.44886033
74BRD40.43930147
75MAP3K80.43723162
76SGK20.43504432
77PIM10.42703093
78MAPK10.42582821
79BMPR20.42489311
80MARK10.42416089
81STK160.41692486
82BRSK10.41098375
83RPS6KB10.40646483
84PRKAA20.40386265
85PLK10.40024354
86TIE10.38892813
87PRPF4B0.38173668
88ATM0.37789240
89MTOR0.37717904
90MAP3K40.37703696
91CDK30.37669829
92PAK10.35782818
93LMTK20.32779020
94SGK10.32750629
95WEE10.32088180
96CAMK40.31639515
97MAP3K10.31244875
98TESK20.31162513
99TAOK20.28491981
100RPS6KL10.28292396
101RPS6KC10.28292396
102CDK40.26886545
103MAPK140.26527124
104RPS6KA60.25664176
105PRKCB0.24967052
106EIF2AK20.24740808
107MET0.23406402
108NTRK30.23279206
109PLK30.23118576
110MAPK100.22987558
111SGK2230.20894190
112SGK4940.20894190
113MKNK20.20150928
114PRKCZ0.19788873
115ARAF0.19102296
116PRKCQ0.18656951
117WNK30.18188263
118PRKAA10.17705849
119MAPK110.17380210
120ERBB30.17215977
121CSNK2A10.17119885
122BCR0.16786593
123JAK30.16456446
124PRKCD0.16145181
125OXSR10.15873572
126PIM20.15614861
127MINK10.15569469
128AKT10.15560573
129MAPK130.15463961
130CHUK0.15024699
131MAP3K50.14517880
132DYRK20.14164285
133IRAK40.14113619
134OBSCN0.13716807
135EPHA20.13658239
136GSK3B0.13646050
137MARK20.13479551
138TNIK0.13038587
139RPS6KA10.12935570
140FRK0.10653540
141PRKACB0.10582689
142GRK10.09977792
143PRKG20.09551755
144SGK30.09464639
145CDK10.09291495
146PRKG10.08991195
147CAMK2A0.08926615
148PRKACA0.08556348
149PKN10.08352692
150BUB10.08300519
151FER0.07792322
152MAPK90.07567665
153CDK20.07362772
154CLK10.06604271
155MAPK80.06409144

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000728.13573986
2Vitamin B6 metabolism_Homo sapiens_hsa007504.43999585
3Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.84805803
4alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.35148303
5Basal transcription factors_Homo sapiens_hsa030223.32123913
6Linoleic acid metabolism_Homo sapiens_hsa005913.26262700
7Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.97061615
8Butanoate metabolism_Homo sapiens_hsa006502.82918684
9Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.74400651
10Fanconi anemia pathway_Homo sapiens_hsa034602.68659556
11Pyruvate metabolism_Homo sapiens_hsa006202.31720363
12Glucagon signaling pathway_Homo sapiens_hsa049222.08371812
13Carbohydrate digestion and absorption_Homo sapiens_hsa049732.04086365
14Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.93519890
15Type II diabetes mellitus_Homo sapiens_hsa049301.81896685
16Glycerophospholipid metabolism_Homo sapiens_hsa005641.80535790
17Mineral absorption_Homo sapiens_hsa049781.75601063
18Purine metabolism_Homo sapiens_hsa002301.73718315
19Phenylalanine metabolism_Homo sapiens_hsa003601.71419977
20Glycerolipid metabolism_Homo sapiens_hsa005611.67217689
21Propanoate metabolism_Homo sapiens_hsa006401.58815585
22Arachidonic acid metabolism_Homo sapiens_hsa005901.58493916
23Fructose and mannose metabolism_Homo sapiens_hsa000511.58114023
24Collecting duct acid secretion_Homo sapiens_hsa049661.57780328
25Amphetamine addiction_Homo sapiens_hsa050311.56192560
26Ether lipid metabolism_Homo sapiens_hsa005651.51954933
27Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.51523862
28Selenocompound metabolism_Homo sapiens_hsa004501.50859333
29Phototransduction_Homo sapiens_hsa047441.48546920
30Glycosaminoglycan degradation_Homo sapiens_hsa005311.35786515
31Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.34065171
32Oocyte meiosis_Homo sapiens_hsa041141.32026657
33mRNA surveillance pathway_Homo sapiens_hsa030151.31551158
34Morphine addiction_Homo sapiens_hsa050321.30747300
35Legionellosis_Homo sapiens_hsa051341.29869792
36RNA transport_Homo sapiens_hsa030131.29170468
37Endocytosis_Homo sapiens_hsa041441.21888301
38Arginine and proline metabolism_Homo sapiens_hsa003301.18055925
39Pentose phosphate pathway_Homo sapiens_hsa000301.14255190
40Protein digestion and absorption_Homo sapiens_hsa049741.14245517
41Hedgehog signaling pathway_Homo sapiens_hsa043401.10110944
42Taste transduction_Homo sapiens_hsa047421.09196620
43Arginine biosynthesis_Homo sapiens_hsa002201.08977169
44ABC transporters_Homo sapiens_hsa020101.07275294
45Antigen processing and presentation_Homo sapiens_hsa046121.06932218
46Pyrimidine metabolism_Homo sapiens_hsa002401.04807989
47Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.96057705
48Primary bile acid biosynthesis_Homo sapiens_hsa001200.95700902
49Cysteine and methionine metabolism_Homo sapiens_hsa002700.95695058
50Huntingtons disease_Homo sapiens_hsa050160.94406619
51Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.93442475
52Insulin secretion_Homo sapiens_hsa049110.91483051
53Dorso-ventral axis formation_Homo sapiens_hsa043200.89807751
54Glutamatergic synapse_Homo sapiens_hsa047240.89114557
55Cardiac muscle contraction_Homo sapiens_hsa042600.88906471
56Homologous recombination_Homo sapiens_hsa034400.88010622
57Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.87729322
58Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.87235037
59Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.86320817
60Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.84829199
61Base excision repair_Homo sapiens_hsa034100.83971623
62Measles_Homo sapiens_hsa051620.80581248
63Fat digestion and absorption_Homo sapiens_hsa049750.79908513
64Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.79810628
65Nicotine addiction_Homo sapiens_hsa050330.79552291
66Renin secretion_Homo sapiens_hsa049240.79528170
67Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.77825524
68Tyrosine metabolism_Homo sapiens_hsa003500.76319903
69Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.76190616
70Rheumatoid arthritis_Homo sapiens_hsa053230.74641041
71Graft-versus-host disease_Homo sapiens_hsa053320.74564086
72Biosynthesis of amino acids_Homo sapiens_hsa012300.73312469
73Glutathione metabolism_Homo sapiens_hsa004800.72332099
74Synaptic vesicle cycle_Homo sapiens_hsa047210.71977809
75Tight junction_Homo sapiens_hsa045300.71704132
76Calcium signaling pathway_Homo sapiens_hsa040200.70328681
77Viral myocarditis_Homo sapiens_hsa054160.70217352
78Allograft rejection_Homo sapiens_hsa053300.69904978
79Serotonergic synapse_Homo sapiens_hsa047260.65982359
80Autoimmune thyroid disease_Homo sapiens_hsa053200.65938771
81Gastric acid secretion_Homo sapiens_hsa049710.64877830
82Aldosterone synthesis and secretion_Homo sapiens_hsa049250.64598351
83Chemical carcinogenesis_Homo sapiens_hsa052040.64253005
84Nitrogen metabolism_Homo sapiens_hsa009100.63161066
85Maturity onset diabetes of the young_Homo sapiens_hsa049500.63147806
86Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.61481351
87GABAergic synapse_Homo sapiens_hsa047270.60520562
88VEGF signaling pathway_Homo sapiens_hsa043700.60461493
89Olfactory transduction_Homo sapiens_hsa047400.60174459
90Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.59277394
91Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.58965644
92Carbon metabolism_Homo sapiens_hsa012000.58337052
93MAPK signaling pathway_Homo sapiens_hsa040100.58257028
94DNA replication_Homo sapiens_hsa030300.56937702
95Non-homologous end-joining_Homo sapiens_hsa034500.55963002
96Cell cycle_Homo sapiens_hsa041100.55272234
97cGMP-PKG signaling pathway_Homo sapiens_hsa040220.54599960
98Systemic lupus erythematosus_Homo sapiens_hsa053220.54268775
99Influenza A_Homo sapiens_hsa051640.53904434
100Bile secretion_Homo sapiens_hsa049760.53184582
101Pancreatic secretion_Homo sapiens_hsa049720.51978475
102Retinol metabolism_Homo sapiens_hsa008300.51877183
103Inositol phosphate metabolism_Homo sapiens_hsa005620.51754596
104Cholinergic synapse_Homo sapiens_hsa047250.51619713
105Pentose and glucuronate interconversions_Homo sapiens_hsa000400.51522131
106Type I diabetes mellitus_Homo sapiens_hsa049400.46654184
107Long-term potentiation_Homo sapiens_hsa047200.44870238
108Herpes simplex infection_Homo sapiens_hsa051680.43104529
109* Metabolic pathways_Homo sapiens_hsa011000.40344782
110RNA degradation_Homo sapiens_hsa030180.39958568
111Circadian entrainment_Homo sapiens_hsa047130.39883249
112Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.39590235
113Phosphatidylinositol signaling system_Homo sapiens_hsa040700.39532267
114Acute myeloid leukemia_Homo sapiens_hsa052210.38842051
115Oxytocin signaling pathway_Homo sapiens_hsa049210.38791365
116Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.36686786
117Transcriptional misregulation in cancer_Homo sapiens_hsa052020.35514382
118Estrogen signaling pathway_Homo sapiens_hsa049150.35126694
119Renin-angiotensin system_Homo sapiens_hsa046140.34933166
120Epstein-Barr virus infection_Homo sapiens_hsa051690.34314930
121Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.33299756
122Phagosome_Homo sapiens_hsa041450.32274662
123cAMP signaling pathway_Homo sapiens_hsa040240.31937814
124Intestinal immune network for IgA production_Homo sapiens_hsa046720.31803599
125Proteasome_Homo sapiens_hsa030500.31486344
126ECM-receptor interaction_Homo sapiens_hsa045120.30923435
127Salivary secretion_Homo sapiens_hsa049700.29532005
128Vascular smooth muscle contraction_Homo sapiens_hsa042700.29077347
129* PPAR signaling pathway_Homo sapiens_hsa033200.29040721
130Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.27289864
131Wnt signaling pathway_Homo sapiens_hsa043100.26302364
132Thyroid hormone synthesis_Homo sapiens_hsa049180.25478511
133Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.25212628
134Adherens junction_Homo sapiens_hsa045200.24721950
135Viral carcinogenesis_Homo sapiens_hsa052030.24706079
136NF-kappa B signaling pathway_Homo sapiens_hsa040640.24145462
137Basal cell carcinoma_Homo sapiens_hsa052170.23646810
138Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.23230291
139Prolactin signaling pathway_Homo sapiens_hsa049170.23148549
140Alcoholism_Homo sapiens_hsa050340.22624873
141Jak-STAT signaling pathway_Homo sapiens_hsa046300.22363649
142Thyroid hormone signaling pathway_Homo sapiens_hsa049190.22188219
143Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.21220961
144AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.19287293
145Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.19207746
146Cocaine addiction_Homo sapiens_hsa050300.17627601

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