ACSL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. Several transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.86647977
2L-phenylalanine catabolic process (GO:0006559)5.86647977
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.61260677
4L-phenylalanine metabolic process (GO:0006558)5.61260677
5triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.39891811
6* alpha-linolenic acid metabolic process (GO:0036109)5.21235571
7fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.17746357
8aromatic amino acid family catabolic process (GO:0009074)5.15715231
9regulation of sequestering of triglyceride (GO:0010889)5.11079351
10regulation of triglyceride catabolic process (GO:0010896)5.05947282
11detection of molecule of bacterial origin (GO:0032490)5.05225867
12modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.00183640
13positive regulation by organism of defense response of other organism involved in symbiotic interact5.00183640
14modulation by symbiont of host immune response (GO:0052553)5.00183640
15positive regulation by symbiont of host defense response (GO:0052509)5.00183640
16modulation by symbiont of host defense response (GO:0052031)5.00183640
17modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.00183640
18complement activation, alternative pathway (GO:0006957)4.84867385
19lysine metabolic process (GO:0006553)4.83006396
20lysine catabolic process (GO:0006554)4.83006396
21fatty acid beta-oxidation (GO:0006635)4.81459459
22fatty acid transmembrane transport (GO:1902001)4.79778278
23glyoxylate metabolic process (GO:0046487)4.76457596
24response to peptidoglycan (GO:0032494)4.75171401
25low-density lipoprotein particle clearance (GO:0034383)4.75026143
26sulfur amino acid catabolic process (GO:0000098)4.74695020
27kynurenine metabolic process (GO:0070189)4.71210193
28valine metabolic process (GO:0006573)4.68943021
29plasma lipoprotein particle clearance (GO:0034381)4.68787785
30macrophage activation involved in immune response (GO:0002281)4.67842383
31bile acid biosynthetic process (GO:0006699)4.66601336
32positive regulation of gamma-delta T cell activation (GO:0046645)4.63187220
33acetyl-CoA metabolic process (GO:0006084)4.61291914
34negative regulation of interleukin-12 production (GO:0032695)4.57956336
35indole-containing compound catabolic process (GO:0042436)4.55032697
36indolalkylamine catabolic process (GO:0046218)4.55032697
37tryptophan catabolic process (GO:0006569)4.55032697
38urea metabolic process (GO:0019627)4.54637039
39urea cycle (GO:0000050)4.54637039
40negative regulation of cell killing (GO:0031342)4.52757813
41negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.52757813
42positive regulation of fatty acid beta-oxidation (GO:0032000)4.52568580
43amino-acid betaine metabolic process (GO:0006577)4.52481583
44fatty acid oxidation (GO:0019395)4.50418734
45positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.49568370
46carnitine shuttle (GO:0006853)4.43632621
47lipid oxidation (GO:0034440)4.42428001
48fatty acid catabolic process (GO:0009062)4.40678531
49cysteine metabolic process (GO:0006534)4.37357910
50acylglycerol homeostasis (GO:0055090)4.36321079
51triglyceride homeostasis (GO:0070328)4.36321079
52positive regulation of lipid catabolic process (GO:0050996)4.31035925
53tryptophan metabolic process (GO:0006568)4.30738083
54biotin metabolic process (GO:0006768)4.27154282
55detection of other organism (GO:0098543)4.24281429
56regulation of protein activation cascade (GO:2000257)4.20360423
57nitrogen cycle metabolic process (GO:0071941)4.19819220
58detection of external biotic stimulus (GO:0098581)4.18160200
592-oxoglutarate metabolic process (GO:0006103)4.16621365
60antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.14117078
61protein carboxylation (GO:0018214)4.13977150
62peptidyl-glutamic acid carboxylation (GO:0017187)4.13977150
63positive regulation of fatty acid oxidation (GO:0046321)4.11986488
64triglyceride catabolic process (GO:0019433)4.11409432
65neutrophil activation involved in immune response (GO:0002283)4.09062674
66monocarboxylic acid catabolic process (GO:0072329)4.07517828
67negative regulation of fibrinolysis (GO:0051918)4.07153072
68cellular ketone body metabolic process (GO:0046950)4.04429303
69short-chain fatty acid metabolic process (GO:0046459)4.03401240
70high-density lipoprotein particle remodeling (GO:0034375)4.03244826
71bile acid metabolic process (GO:0008206)4.02141908
72serine family amino acid catabolic process (GO:0009071)4.01747236
73homocysteine metabolic process (GO:0050667)4.01171637
74regulation of complement activation (GO:0030449)3.99036875
75neutral lipid catabolic process (GO:0046461)3.98881982
76acylglycerol catabolic process (GO:0046464)3.98881982
77carnitine metabolic process (GO:0009437)3.97529142
78branched-chain amino acid catabolic process (GO:0009083)3.96662615
79regulation of interferon-beta biosynthetic process (GO:0045357)3.95139495
80ethanol oxidation (GO:0006069)3.91827951
81alpha-amino acid catabolic process (GO:1901606)3.88815558
82regulation of fibrinolysis (GO:0051917)3.87877397
83plasma lipoprotein particle remodeling (GO:0034369)3.81928423
84protein-lipid complex remodeling (GO:0034368)3.81928423
85macromolecular complex remodeling (GO:0034367)3.81928423
86branched-chain amino acid metabolic process (GO:0009081)3.79984579
87phospholipid homeostasis (GO:0055091)3.79773205
88regulation of fatty acid beta-oxidation (GO:0031998)3.76175644
89detection of bacterium (GO:0016045)3.74076668
90tyrosine metabolic process (GO:0006570)3.73213688
91cellular extravasation (GO:0045123)3.72501295
92detection of biotic stimulus (GO:0009595)3.70393129
93cellular amino acid catabolic process (GO:0009063)3.69236734
94reverse cholesterol transport (GO:0043691)3.67640178
95aspartate family amino acid catabolic process (GO:0009068)3.67613826
96carnitine transmembrane transport (GO:1902603)3.67611530
97aromatic amino acid family metabolic process (GO:0009072)3.67508842
98organic acid catabolic process (GO:0016054)3.66851646
99carboxylic acid catabolic process (GO:0046395)3.66851646
100regulation of fatty acid oxidation (GO:0046320)3.66621255
101coenzyme catabolic process (GO:0009109)3.64178747
102lipopolysaccharide-mediated signaling pathway (GO:0031663)3.60688049
103amino-acid betaine transport (GO:0015838)3.57986666
104carnitine transport (GO:0015879)3.57986666
105regulation of cholesterol storage (GO:0010885)3.57104520
106antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.56787540
107macrophage activation (GO:0042116)3.55275042
108negative regulation of lipase activity (GO:0060192)3.54228866
109regulation of cholesterol esterification (GO:0010872)3.51497757
110positive regulation of triglyceride metabolic process (GO:0090208)3.50621761
111microglial cell activation (GO:0001774)3.50031676
112phospholipid efflux (GO:0033700)3.49558050
113response to host immune response (GO:0052572)3.47203077
114response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.47203077
115ketone body metabolic process (GO:1902224)3.47010298
116regulation of triglyceride metabolic process (GO:0090207)3.46519889
117positive regulation of triglyceride lipase activity (GO:0061365)3.46501941
118positive regulation of lipoprotein lipase activity (GO:0051006)3.46501941
119regulation of gamma-delta T cell activation (GO:0046643)3.45175767
120cellular response to type I interferon (GO:0071357)3.38511428
121type I interferon signaling pathway (GO:0060337)3.38511428
122negative regulation of fatty acid biosynthetic process (GO:0045717)3.38379477
123antigen processing and presentation of endogenous antigen (GO:0019883)3.37354919
124response to type I interferon (GO:0034340)3.35170952
125germinal center formation (GO:0002467)3.34532621
126positive regulation of fatty acid metabolic process (GO:0045923)3.33969462
127regulation of cholesterol metabolic process (GO:0090181)3.31778250
128cholesterol homeostasis (GO:0042632)3.29705163
129* thioester biosynthetic process (GO:0035384)3.29544061
130* acyl-CoA biosynthetic process (GO:0071616)3.29544061
131immunoglobulin mediated immune response (GO:0016064)3.28988250
132dicarboxylic acid biosynthetic process (GO:0043650)3.28844472
133tricarboxylic acid metabolic process (GO:0072350)3.28196226
134* acyl-CoA metabolic process (GO:0006637)3.27875755
135* thioester metabolic process (GO:0035383)3.27875755
136leukocyte aggregation (GO:0070486)3.24856578
137antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.21813756
138production of molecular mediator involved in inflammatory response (GO:0002532)3.21733104
139positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.19759000
140negative regulation of lymphocyte mediated immunity (GO:0002707)3.19159561
141regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.18345009
142neutrophil activation (GO:0042119)3.18155276
143positive regulation of cellular amide metabolic process (GO:0034250)3.16403912
144response to host (GO:0075136)3.15715819
145response to host defenses (GO:0052200)3.15715819
146response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.15715819
147regulation of interferon-alpha production (GO:0032647)3.13972231
148granulocyte activation (GO:0036230)3.13662456
149positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.11823306
150regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.09974990
151regulation of B cell receptor signaling pathway (GO:0050855)3.08858422
152positive regulation of interferon-alpha production (GO:0032727)3.07533631
153leukocyte migration involved in inflammatory response (GO:0002523)3.07129091
154positive regulation of toll-like receptor signaling pathway (GO:0034123)3.06835780
155neutrophil mediated immunity (GO:0002446)3.06398047
156T-helper 1 type immune response (GO:0042088)3.04977017
157regulation of T-helper 2 cell differentiation (GO:0045628)3.04261016
158regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.03553345
159myeloid cell activation involved in immune response (GO:0002275)3.00579037
160interferon-gamma-mediated signaling pathway (GO:0060333)2.92971369
161negative regulation of cytokine production involved in immune response (GO:0002719)2.92618352
162respiratory burst (GO:0045730)2.88987825
163defense response to protozoan (GO:0042832)2.88601715
164response to muramyl dipeptide (GO:0032495)2.83887243
165positive regulation of macrophage cytokine production (GO:0060907)2.82148637
166negative regulation of leukocyte mediated immunity (GO:0002704)2.81837131
167negative regulation of T cell mediated immunity (GO:0002710)2.81013308
168positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.77378445
169regulation of mast cell degranulation (GO:0043304)2.73712950
170regulation of interleukin-8 biosynthetic process (GO:0045414)2.71704992
171negative regulation of erythrocyte differentiation (GO:0045647)2.71431093
172regulation of gamma-delta T cell differentiation (GO:0045586)2.70551173
173positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.66598994
174myeloid leukocyte mediated immunity (GO:0002444)2.66140588
175positive regulation of type 2 immune response (GO:0002830)2.65854693
176regulation of macrophage cytokine production (GO:0010935)2.65242269
177negative regulation of innate immune response (GO:0045824)2.64280392
178JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.63894044
179response to protozoan (GO:0001562)2.62372364
180regulation of toll-like receptor signaling pathway (GO:0034121)2.60423976
181neutrophil chemotaxis (GO:0030593)2.59492167
182negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.59129360
183response to interleukin-15 (GO:0070672)2.57994054
184lipid storage (GO:0019915)2.55783836
185regulation of myeloid leukocyte mediated immunity (GO:0002886)2.54441788
186regulation of tolerance induction (GO:0002643)2.54143541
187neutrophil migration (GO:1990266)2.54043094
188positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.53308533
189positive regulation of interferon-beta production (GO:0032728)2.52046722
190positive regulation of NF-kappaB import into nucleus (GO:0042346)2.51865967
191negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.49959780
192hydrogen peroxide biosynthetic process (GO:0050665)2.49883331
193regulation of mast cell activation involved in immune response (GO:0033006)2.48862176
194regulation of dendritic cell antigen processing and presentation (GO:0002604)2.48303197
195negative regulation of interleukin-6 production (GO:0032715)2.47629328
196regulation of T cell tolerance induction (GO:0002664)2.46811247
197regulation of type 2 immune response (GO:0002828)2.45249864
198positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.45236520
199myeloid leukocyte activation (GO:0002274)2.44544462

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.50687160
2* PPARG_19300518_ChIP-PET_3T3-L1_Mouse8.44032679
3RXR_22158963_ChIP-Seq_LIVER_Mouse6.91758988
4* PPARA_22158963_ChIP-Seq_LIVER_Mouse5.99689309
5* LXR_22158963_ChIP-Seq_LIVER_Mouse5.63241165
6EGR1_23403033_ChIP-Seq_LIVER_Mouse5.07374726
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.56894168
8BP1_19119308_ChIP-ChIP_Hs578T_Human4.52972515
9IRF8_21731497_ChIP-ChIP_J774_Mouse3.99229403
10* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.89336270
11CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.70004864
12NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.67710822
13FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.03774075
14STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.97077898
15MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.91496451
16* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.72691145
17CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.72103687
18STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.43971677
19CLOCK_20551151_ChIP-Seq_293T_Human2.38659253
20IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.38604289
21SMAD_19615063_ChIP-ChIP_OVARY_Human2.30885030
22RUNX_20019798_ChIP-Seq_JUKART_Human2.13435147
23* VDR_24763502_ChIP-Seq_THP-1_Human2.04885139
24SPI1_23127762_ChIP-Seq_K562_Human2.04803012
25* VDR_24787735_ChIP-Seq_THP-1_Human1.91586972
26STAT4_19710469_ChIP-ChIP_TH1__Mouse1.91483165
27EGR1_19374776_ChIP-ChIP_THP-1_Human1.90568538
28* SPI1_23547873_ChIP-Seq_NB4_Human1.85132849
29TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.82781115
30* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.82542378
31VDR_21846776_ChIP-Seq_THP-1_Human1.81253424
32SCL_19346495_ChIP-Seq_HPC-7_Human1.74306658
33GATA1_22025678_ChIP-Seq_K562_Human1.73809590
34FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.66406122
35SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.63754216
36RUNX1_22412390_ChIP-Seq_EML_Mouse1.62382056
37STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.62040789
38STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.58931339
39VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.58483526
40HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.58221871
41MAF_26560356_Chip-Seq_TH1_Human1.58204203
42E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.54568393
43* FOXA2_19822575_ChIP-Seq_HepG2_Human1.52233436
44KDM2B_26808549_Chip-Seq_SUP-B15_Human1.50803126
45CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.48294771
46MYB_26560356_Chip-Seq_TH2_Human1.45561789
47TCF7_22412390_ChIP-Seq_EML_Mouse1.41656863
48RARG_19884340_ChIP-ChIP_MEFs_Mouse1.41414708
49IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.41349432
50PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.39632440
51PU_27001747_Chip-Seq_BMDM_Mouse1.37441509
52ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.37071794
53LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.36003865
54TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.32237669
55IRF8_22096565_ChIP-ChIP_GC-B_Human1.31533138
56LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.29670806
57THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.28755285
58MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.27951245
59MYB_26560356_Chip-Seq_TH1_Human1.27748528
60ZNF263_19887448_ChIP-Seq_K562_Human1.27729743
61ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.25897703
62Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.25240348
63CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.23397758
64KDM2B_26808549_Chip-Seq_DND41_Human1.20613366
65UTX_26944678_Chip-Seq_JUKART_Human1.19292648
66* HNF4A_19822575_ChIP-Seq_HepG2_Human1.18896772
67CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.16759103
68PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.15812330
69GATA2_22383799_ChIP-Seq_G1ME_Mouse1.14166515
70PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.14087507
71KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.11908394
72GATA3_27048872_Chip-Seq_THYMUS_Human1.11770222
73GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.09585037
74CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09068435
75CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08872104
76BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.08092340
77* TBX20_22328084_ChIP-Seq_HEART_Mouse1.06407284
78* TBX20_22080862_ChIP-Seq_HEART_Mouse1.06407284
79NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.06149151
80PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.05678021
81ELK3_25401928_ChIP-Seq_HUVEC_Human1.05356603
82SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04925331
83PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.04667782
84* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03831670
85PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.02730373
86MAF_26560356_Chip-Seq_TH2_Human1.02556030
87* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.01289762
88KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.00391858
89ESR2_21235772_ChIP-Seq_MCF-7_Human1.00267042
90PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.99673513
91GATA3_26560356_Chip-Seq_TH2_Human0.98916579
92* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98021782
93HTT_18923047_ChIP-ChIP_STHdh_Human0.98014958
94PPAR_26484153_Chip-Seq_NCI-H1993_Human0.97635913
95STAT6_21828071_ChIP-Seq_BEAS2B_Human0.97269030
96* SOX2_27498859_Chip-Seq_STOMACH_Mouse0.96625316
97GATA1_22383799_ChIP-Seq_G1ME_Mouse0.95580395
98* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.95057152
99RXRA_24833708_ChIP-Seq_LIVER_Mouse0.93613351
100GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90721210
101CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.89048305
102TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.87540443
103GATA1_19941827_ChIP-Seq_MEL86_Mouse0.84131166
104NRF2_20460467_ChIP-Seq_MEFs_Mouse0.84007927
105NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.84007927
106MYC_22102868_ChIP-Seq_BL_Human0.83467320
107TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.82747183
108GATA4_25053715_ChIP-Seq_YYC3_Human0.82683035
109EP300_21415370_ChIP-Seq_HL-1_Mouse0.81802478
110FOXO3_23340844_ChIP-Seq_DLD1_Human0.80257468
111AUTS2_25519132_ChIP-Seq_293T-REX_Human0.79397379
112KDM2B_26808549_Chip-Seq_JURKAT_Human0.79393962
113ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.77689494
114SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.76391776
115GATA1_19941826_ChIP-Seq_K562_Human0.74350713
116AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.73638484
117RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.69959096
118NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.69633385
119SALL4_18804426_ChIP-ChIP_XEN_Mouse0.69555262
120GATA2_19941826_ChIP-Seq_K562_Human0.69431319
121TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.68455164
122* CEBPB_22108803_ChIP-Seq_LS180_Human0.67751214
123* ESR1_20079471_ChIP-ChIP_T-47D_Human0.66734339
124GATA2_21666600_ChIP-Seq_HMVEC_Human0.64828780
125RAD21_21589869_ChIP-Seq_MESCs_Mouse0.64751914
126EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.63236626
127NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.62401377
128LXR_22292898_ChIP-Seq_THP-1_Human0.62269449
129TRIM28_21343339_ChIP-Seq_HEK293_Human0.61011593
130PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.60392502
131CDX2_19796622_ChIP-Seq_MESCs_Mouse0.59768002
132EGR1_19032775_ChIP-ChIP_M12_Human0.58753549
133FOXA1_25552417_ChIP-Seq_VCAP_Human0.57611442
134ESR1_21235772_ChIP-Seq_MCF-7_Human0.56484054
135CBP_21632823_ChIP-Seq_H3396_Human0.56005985
136FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.55984742
137PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.55275180
138SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.54637400
139RARA_24833708_ChIP-Seq_LIVER_Mouse0.53561651
140BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.53264435
141BCAT_22108803_ChIP-Seq_LS180_Human0.53080017
142ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.52554295
143BRD4_27068464_Chip-Seq_AML-cells_Mouse0.52496241
144SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.52346103
145STAT3_1855785_ChIP-Seq_MESCs_Mouse0.51977923
146IRF8_27001747_Chip-Seq_BMDM_Mouse0.51874783
147SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.51233697
148GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.50791897
149GATA1_19941827_ChIP-Seq_MEL_Mouse0.50588860
150NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.50240743
151SOX9_24532713_ChIP-Seq_HFSC_Mouse0.50047995
152STAT1_17558387_ChIP-Seq_HELA_Human0.49245803
153P63_26484246_Chip-Seq_KERATINOCYTES_Human0.48926377
154ESET_19884257_ChIP-Seq_ESCs_Mouse0.48837959
155GATA3_24758297_ChIP-Seq_MCF-7_Human0.48432949
156CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.48050904
157ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.48031063
158BCOR_27268052_Chip-Seq_Bcells_Human0.47853522
159FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.47314122
160TP63_17297297_ChIP-ChIP_HaCaT_Human0.46862422
161P53_21459846_ChIP-Seq_SAOS-2_Human0.45797376
162SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.45641312

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.58489494
2MP0005360_urolithiasis5.82525066
3MP0005365_abnormal_bile_salt5.08642819
4MP0005085_abnormal_gallbladder_physiolo4.89700725
5MP0003303_peritoneal_inflammation4.37836958
6MP0005670_abnormal_white_adipose3.63342404
7MP0008875_abnormal_xenobiotic_pharmacok3.62324221
8MP0010329_abnormal_lipoprotein_level3.58143770
9MP0003436_decreased_susceptibility_to3.39444828
10MP0003806_abnormal_nucleotide_metabolis3.18650542
11MP0003252_abnormal_bile_duct3.02674674
12MP0004130_abnormal_muscle_cell2.91372546
13MP0009785_altered_susceptibility_to2.91136103
14MP0001835_abnormal_antigen_presentation2.82654085
15MP0002837_dystrophic_cardiac_calcinosis2.68331945
16MP0002419_abnormal_innate_immunity2.67160447
17MP0003191_abnormal_cellular_cholesterol2.58297306
18MP0005666_abnormal_adipose_tissue2.51638778
19MP0009840_abnormal_foam_cell2.49897164
20MP0006082_CNS_inflammation2.46528059
21MP0005332_abnormal_amino_acid2.46514025
22MP0003300_gastrointestinal_ulcer2.42137087
23MP0005083_abnormal_biliary_tract2.40318840
24MP0005025_abnormal_response_to2.38065032
25MP0002148_abnormal_hypersensitivity_rea2.37285800
26* MP0002118_abnormal_lipid_homeostasis2.36748745
27MP0005000_abnormal_immune_tolerance2.32649254
28MP0003195_calcinosis2.27057073
29MP0001790_abnormal_immune_system2.22347910
30MP0005387_immune_system_phenotype2.22347910
31MP0000609_abnormal_liver_physiology2.14626271
32MP0001800_abnormal_humoral_immune2.05986979
33MP0000685_abnormal_immune_system2.02828184
34MP0004510_myositis2.02825216
35MP0001533_abnormal_skeleton_physiology1.98914247
36MP0005671_abnormal_response_to1.96340228
37MP0001666_abnormal_nutrient_absorption1.96232021
38MP0002723_abnormal_immune_serum1.95646832
39MP0002452_abnormal_antigen_presenting1.90247285
40MP0004185_abnormal_adipocyte_glucose1.88774325
41MP0002971_abnormal_brown_adipose1.85726624
42MP0005319_abnormal_enzyme/_coenzyme1.85201825
43MP0003828_pulmonary_edema1.82510560
44MP0004947_skin_inflammation1.76098877
45MP0008260_abnormal_autophagy1.75509852
46MP0002420_abnormal_adaptive_immunity1.72566898
47MP0001819_abnormal_immune_cell1.71482965
48MP0003646_muscle_fatigue1.70060322
49MP0005584_abnormal_enzyme/coenzyme_acti1.67462009
50MP0004019_abnormal_vitamin_homeostasis1.66053994
51MP0005375_adipose_tissue_phenotype1.60956480
52MP0001845_abnormal_inflammatory_respons1.58580796
53MP0003172_abnormal_lysosome_physiology1.54810856
54MP0003705_abnormal_hypodermis_morpholog1.53621977
55MP0003186_abnormal_redox_activity1.53572788
56MP0005464_abnormal_platelet_physiology1.52913333
57MP0001764_abnormal_homeostasis1.52729605
58MP0002405_respiratory_system_inflammati1.49096017
59MP0009278_abnormal_bone_marrow1.46387562
60MP0005164_abnormal_response_to1.45196830
61MP0005334_abnormal_fat_pad1.44627609
62MP0001545_abnormal_hematopoietic_system1.43654009
63MP0005397_hematopoietic_system_phenotyp1.43654009
64MP0000858_altered_metastatic_potential1.42780119
65MP0006036_abnormal_mitochondrial_physio1.41760343
66MP0010155_abnormal_intestine_physiology1.41240073
67MP0004883_abnormal_blood_vessel1.33397068
68MP0005535_abnormal_body_temperature1.33323712
69MP0008438_abnormal_cutaneous_collagen1.32186814
70MP0005451_abnormal_body_composition1.29610470
71MP0002998_abnormal_bone_remodeling1.29428517
72MP0005166_decreased_susceptibility_to1.27729758
73MP0009643_abnormal_urine_homeostasis1.27429019
74MP0009115_abnormal_fat_cell1.22802635
75MP0003011_delayed_dark_adaptation1.21738930
76MP0002138_abnormal_hepatobiliary_system1.21121818
77MP0008004_abnormal_stomach_pH1.20911726
78MP0000716_abnormal_immune_system1.20311903
79MP0001661_extended_life_span1.18336445
80MP0003448_altered_tumor_morphology1.15391048
81MP0005330_cardiomyopathy1.14964643
82MP0002078_abnormal_glucose_homeostasis1.14610182
83MP0003656_abnormal_erythrocyte_physiolo1.14491122
84MP0002132_abnormal_respiratory_system1.13535240
85MP0002876_abnormal_thyroid_physiology1.11491755
86MP0002398_abnormal_bone_marrow1.06975704
87MP0003868_abnormal_feces_composition1.05760248
88MP0003724_increased_susceptibility_to1.03608972
89MP0001851_eye_inflammation1.02954180
90MP0000598_abnormal_liver_morphology1.02816574
91MP0002254_reproductive_system_inflammat1.01660204
92MP0000604_amyloidosis1.01617670
93MP0009763_increased_sensitivity_to1.01057126
94MP0003690_abnormal_glial_cell1.00435670
95MP0002970_abnormal_white_adipose0.97910078
96MP0000465_gastrointestinal_hemorrhage0.97609440
97MP0003763_abnormal_thymus_physiology0.96665916
98MP0005448_abnormal_energy_balance0.96568809
99MP0003453_abnormal_keratinocyte_physiol0.96380863
100MP0005647_abnormal_sex_gland0.96189722
101MP0009764_decreased_sensitivity_to0.94360809
102MP0000689_abnormal_spleen_morphology0.93433385
103MP0008775_abnormal_heart_ventricle0.93072818
104MP0009333_abnormal_splenocyte_physiolog0.92974750
105MP0005310_abnormal_salivary_gland0.90197713
106MP0002722_abnormal_immune_system0.89980775
107MP0009697_abnormal_copulation0.88636009
108MP0002429_abnormal_blood_cell0.88089881
109MP0008469_abnormal_protein_level0.84771156
110MP0003221_abnormal_cardiomyocyte_apopto0.84466350
111MP0001544_abnormal_cardiovascular_syste0.83274840
112MP0005385_cardiovascular_system_phenoty0.83274840
113MP0000751_myopathy0.83226657
114MP0000003_abnormal_adipose_tissue0.83045584
115MP0003183_abnormal_peptide_metabolism0.82482775
116MP0004215_abnormal_myocardial_fiber0.82269550
117MP0005275_abnormal_skin_tensile0.82111203
118MP0002277_abnormal_respiratory_mucosa0.81619206
119MP0004087_abnormal_muscle_fiber0.81444713
120MP0000249_abnormal_blood_vessel0.81209699
121MP0004036_abnormal_muscle_relaxation0.81110147
122MP0009642_abnormal_blood_homeostasis0.80383394
123MP0001756_abnormal_urination0.80197392
124MP0003045_fibrosis0.80096353
125MP0001881_abnormal_mammary_gland0.79849360
126MP0005376_homeostasis/metabolism_phenot0.79249750
127MP0003091_abnormal_cell_migration0.78846497
128MP0006138_congestive_heart_failure0.78470811
129MP0004381_abnormal_hair_follicle0.77907512
130MP0005266_abnormal_metabolism0.76774232
131MP0004084_abnormal_cardiac_muscle0.76019324
132MP0010368_abnormal_lymphatic_system0.75707494
133MP0008874_decreased_physiological_sensi0.73816373
134MP0002332_abnormal_exercise_endurance0.73696369
135MP0005636_abnormal_mineral_homeostasis0.72872546
136MP0003959_abnormal_lean_body0.72485939
137MP0005390_skeleton_phenotype0.71510466
138MP0002972_abnormal_cardiac_muscle0.68933521
139MP0002269_muscular_atrophy0.68754796
140MP0006035_abnormal_mitochondrial_morpho0.68122380
141MP0000013_abnormal_adipose_tissue0.67579104
142MP0005620_abnormal_muscle_contractility0.67201577
143MP0005058_abnormal_lysosome_morphology0.66316538
144MP0010630_abnormal_cardiac_muscle0.63827814
145MP0002796_impaired_skin_barrier0.63477423
146MP0000343_altered_response_to0.62159081
147MP0000230_abnormal_systemic_arterial0.61248429
148MP0003329_amyloid_beta_deposits0.60849579
149MP0000749_muscle_degeneration0.59935527
150MP0005452_abnormal_adipose_tissue0.57240349
151MP0003953_abnormal_hormone_level0.55516608
152MP0004147_increased_porphyrin_level0.55087394
153MP0001853_heart_inflammation0.54934690
154MP0002060_abnormal_skin_morphology0.50890420
155MP0002136_abnormal_kidney_physiology0.50842609
156MP0005167_abnormal_blood-brain_barrier0.50300188
157MP0009765_abnormal_xenobiotic_induced0.50253582
158MP0003075_altered_response_to0.50106504
159MP0002168_other_aberrant_phenotype0.48651274

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.70656464
2Orchitis (HP:0100796)5.48155197
3Xanthomatosis (HP:0000991)5.47723168
4Deep venous thrombosis (HP:0002625)5.46036239
5Intrahepatic cholestasis (HP:0001406)5.38511790
6Retrobulbar optic neuritis (HP:0100654)5.31847865
7Optic neuritis (HP:0100653)5.31847865
8Abnormality of aromatic amino acid family metabolism (HP:0004338)5.16475236
9Myositis (HP:0100614)5.15141818
10Recurrent bacterial skin infections (HP:0005406)4.95013864
11Hyperglycinuria (HP:0003108)4.92721670
12Hyperlipoproteinemia (HP:0010980)4.91863791
13Recurrent abscess formation (HP:0002722)4.90030446
14Complement deficiency (HP:0004431)4.84619775
15Abnormality of macrophages (HP:0004311)4.67091604
16Hyperammonemia (HP:0001987)4.64132248
17Ketosis (HP:0001946)4.63593986
18Hypoglycemic coma (HP:0001325)4.56814437
19Abnormality of glycine metabolism (HP:0010895)4.56760607
20Abnormality of serine family amino acid metabolism (HP:0010894)4.56760607
21Prolonged partial thromboplastin time (HP:0003645)4.52296760
22Abnormality of monocarboxylic acid metabolism (HP:0010996)4.49151708
23Abnormality of fatty-acid metabolism (HP:0004359)4.41877715
24Hypobetalipoproteinemia (HP:0003563)4.37825951
25Epidermoid cyst (HP:0200040)4.35783901
26Hypoalphalipoproteinemia (HP:0003233)4.24640189
27Hyperglycinemia (HP:0002154)4.23496781
28Hypolipoproteinemia (HP:0010981)4.07091248
29Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.01346890
30Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.97592893
31Keratoconjunctivitis sicca (HP:0001097)3.95895512
32Stomatitis (HP:0010280)3.91699472
33Ketoacidosis (HP:0001993)3.89887431
34Mediastinal lymphadenopathy (HP:0100721)3.61172653
35Abnormality of glutamine family amino acid metabolism (HP:0010902)3.60764881
36Gastrointestinal infarctions (HP:0005244)3.60436529
37Keratoconjunctivitis (HP:0001096)3.58685863
38Abnormality of complement system (HP:0005339)3.49661902
39Dicarboxylic aciduria (HP:0003215)3.46899363
40Abnormality of dicarboxylic acid metabolism (HP:0010995)3.46899363
41Myoglobinuria (HP:0002913)3.45166018
42Joint hemorrhage (HP:0005261)3.44121076
43Hypercholesterolemia (HP:0003124)3.43136066
44Abnormality of glycolipid metabolism (HP:0010969)3.39422176
45Abnormality of liposaccharide metabolism (HP:0010968)3.39422176
46Abnormality of glycosphingolipid metabolism (HP:0004343)3.39422176
47Elevated erythrocyte sedimentation rate (HP:0003565)3.36008118
48Abnormality of the common coagulation pathway (HP:0010990)3.31752900
49Gingivitis (HP:0000230)3.25590569
50Abnormality of aspartate family amino acid metabolism (HP:0010899)3.15701184
51Abnormality of sulfur amino acid metabolism (HP:0004339)3.10677555
52Myocardial infarction (HP:0001658)3.06536160
53Skin nodule (HP:0200036)3.04016723
54Recurrent skin infections (HP:0001581)3.03029025
55Vasculitis (HP:0002633)2.99249876
56Arterial thrombosis (HP:0004420)2.96291468
57Meningitis (HP:0001287)2.95236935
58Increased IgE level (HP:0003212)2.92983299
59Hypertriglyceridemia (HP:0002155)2.92972157
60Abnormality of methionine metabolism (HP:0010901)2.92714775
61Obstructive lung disease (HP:0006536)2.92531903
62Chronic obstructive pulmonary disease (HP:0006510)2.92531903
63Recurrent fungal infections (HP:0002841)2.92224001
64Abnormality of serum amino acid levels (HP:0003112)2.91683087
65Fat malabsorption (HP:0002630)2.90273034
66Gingival bleeding (HP:0000225)2.89176707
67Gangrene (HP:0100758)2.84996468
68Metabolic acidosis (HP:0001942)2.84409734
69Rhabdomyolysis (HP:0003201)2.83332170
70Spontaneous hematomas (HP:0007420)2.83050421
71Abnormality of the intrinsic pathway (HP:0010989)2.82762288
72Hemoptysis (HP:0002105)2.82060097
73Peritonitis (HP:0002586)2.81607814
74Abnormality of purine metabolism (HP:0004352)2.80112155
75Pulmonary infiltrates (HP:0002113)2.79317308
76Urticaria (HP:0001025)2.76207383
77Cerebral edema (HP:0002181)2.70311136
78Encephalitis (HP:0002383)2.70171348
79Lethargy (HP:0001254)2.70082207
80Pulmonary embolism (HP:0002204)2.68276938
81Generalized aminoaciduria (HP:0002909)2.67001486
82Nausea (HP:0002018)2.60197149
83Abnormality of nucleobase metabolism (HP:0010932)2.59952757
84Oligomenorrhea (HP:0000876)2.59634734
85Anorexia (HP:0002039)2.59353908
86Hyperbilirubinemia (HP:0002904)2.55499810
87Loss of speech (HP:0002371)2.53957463
88Systemic lupus erythematosus (HP:0002725)2.50438512
89Hemorrhage of the eye (HP:0011885)2.50352557
90Abnormality of proline metabolism (HP:0010907)2.49740018
91Hydroxyprolinuria (HP:0003080)2.49740018
92Episodic fever (HP:0001954)2.42671017
93Pancreatitis (HP:0001733)2.41286208
94Increased cerebral lipofuscin (HP:0011813)2.41034124
95T lymphocytopenia (HP:0005403)2.39849449
96Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.38838076
97Delayed CNS myelination (HP:0002188)2.38491003
98Cholelithiasis (HP:0001081)2.38102435
99Chest pain (HP:0100749)2.37305787
100Abnormal gallbladder morphology (HP:0012437)2.35943819
101Difficulty running (HP:0009046)2.35514741
102Vomiting (HP:0002013)2.34520485
103Hypoglycemic seizures (HP:0002173)2.34119581
104Cellulitis (HP:0100658)2.32820064
105Acanthosis nigricans (HP:0000956)2.32002540
106Increased serum ferritin (HP:0003281)2.31279936
107Conjugated hyperbilirubinemia (HP:0002908)2.30079538
108Hepatocellular carcinoma (HP:0001402)2.30065784
109Prolonged bleeding time (HP:0003010)2.29973256
110Increased muscle lipid content (HP:0009058)2.29069063
111Abnormality of T cell number (HP:0011839)2.27221421
112Recurrent gram-negative bacterial infections (HP:0005420)2.26486917
113Dysostosis multiplex (HP:0000943)2.26344869
114Epistaxis (HP:0000421)2.22417534
115Muscle fiber splitting (HP:0003555)2.21860812
116Abnormality of pyrimidine metabolism (HP:0004353)2.19633963
117Abnormality of the endocardium (HP:0004306)2.19100087
118Renal cortical cysts (HP:0000803)2.17577633
119Abnormal delayed hypersensitivity skin test (HP:0002963)2.17506655
120Gout (HP:0001997)2.17148719
121Leukocytosis (HP:0001974)2.16316626
122Polycythemia (HP:0001901)2.15922175
123Chronic mucocutaneous candidiasis (HP:0002728)2.15511857
124Recurrent cutaneous fungal infections (HP:0011370)2.15511857
125Hyperinsulinemic hypoglycemia (HP:0000825)2.15161652
126Purpura (HP:0000979)2.14161265
127Proximal tubulopathy (HP:0000114)2.13652062
128Abnormality of the pleura (HP:0002103)2.12993953
129Abnormal gallbladder physiology (HP:0012438)2.11740460
130Cholecystitis (HP:0001082)2.11740460
131Steatorrhea (HP:0002570)2.11573931
132Hypochromic microcytic anemia (HP:0004840)2.11444846
133Hyperglycemia (HP:0003074)2.11304562
134Disinhibition (HP:0000734)2.10164811
135Acne (HP:0001061)2.09420934
136Asymmetric septal hypertrophy (HP:0001670)2.08936937
137Exercise-induced myalgia (HP:0003738)2.08928098
138Polyneuropathy (HP:0001271)2.06773280
139Abnormality of iron homeostasis (HP:0011031)2.06610625
140Abnormal cartilage morphology (HP:0002763)2.05642011
141Hepatic necrosis (HP:0002605)2.05235078
142Vertigo (HP:0002321)2.05215828
143Thrombophlebitis (HP:0004418)2.04743526
144Abnormality of the peritoneum (HP:0002585)2.04276497
145Increased IgM level (HP:0003496)2.04015811
146Glomerulopathy (HP:0100820)2.02905301
147Vacuolated lymphocytes (HP:0001922)2.02881960
148Right ventricular cardiomyopathy (HP:0011663)2.02669147
149Vascular calcification (HP:0004934)2.01688303
150Pigmentary retinal degeneration (HP:0001146)2.00698338
151Amyloidosis (HP:0011034)2.00265638
152Brushfield spots (HP:0001088)1.99122506
153Colitis (HP:0002583)1.98806987
154Increased purine levels (HP:0004368)1.98084873
155Hyperuricemia (HP:0002149)1.98084873
156Autoimmune thrombocytopenia (HP:0001973)1.95540835
157Recurrent viral infections (HP:0004429)1.95450018
158Hepatosplenomegaly (HP:0001433)1.95011586
159Acanthocytosis (HP:0001927)1.93691238
160Slow saccadic eye movements (HP:0000514)1.93349899
161Abnormality of mucopolysaccharide metabolism (HP:0011020)1.93205679
162Abnormality of polysaccharide metabolism (HP:0011012)1.93205679
163Abnormality of glycosaminoglycan metabolism (HP:0004371)1.93205679
164Inflammation of the large intestine (HP:0002037)1.92608161
165Hypergammaglobulinemia (HP:0010702)1.92574285
166Sensorimotor neuropathy (HP:0007141)1.91882681
167Joint swelling (HP:0001386)1.91540978
168Spontaneous abortion (HP:0005268)1.90761603
169Hypochromic anemia (HP:0001931)1.89595646
170Osteomyelitis (HP:0002754)1.89146890
171Interstitial pulmonary disease (HP:0006530)1.89116534
172Spastic diplegia (HP:0001264)1.89103568
173Esophageal varix (HP:0002040)1.88914714
174Neonatal onset (HP:0003623)1.88261106
175Cardiovascular calcification (HP:0011915)1.87033863
176Irritability (HP:0000737)1.87014111
177Glomerulonephritis (HP:0000099)1.86262624
178Urinary glycosaminoglycan excretion (HP:0003541)1.85084800
179Mucopolysacchariduria (HP:0008155)1.85084800
180Sudden death (HP:0001699)1.85027291
181Late onset (HP:0003584)1.84825285
182Elevated hepatic transaminases (HP:0002910)1.83048022
183Hyporeflexia of lower limbs (HP:0002600)1.82655797
184Increased connective tissue (HP:0009025)1.79204562
185Abnormality of the gallbladder (HP:0005264)1.78801395
186Insulin resistance (HP:0000855)1.78153198

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.00104065
2RIPK44.05911862
3SIK14.05728728
4TRIB33.71481477
5PDK33.38904641
6PDK43.38904641
7ERN13.22647143
8CAMK1D3.15802273
9IRAK42.95917040
10BLK2.93303772
11FGFR42.65083028
12PKN22.55099263
13INSRR2.41476206
14PRPF4B2.26261851
15MAP4K12.20418937
16CAMK1G2.19521018
17PDK22.10422024
18ZAP701.87829452
19FGR1.85483980
20MST1R1.84191007
21TAOK11.79751781
22TTN1.73603587
23MATK1.67553580
24PRKAA21.62680895
25MAP3K111.55562583
26LMTK21.55508501
27FLT31.52431622
28RIPK11.52019567
29TAOK21.51828310
30FES1.49713165
31MAP3K11.44556500
32GRK71.42815822
33MAP3K131.41153123
34OBSCN1.37185957
35TNK21.35827422
36PINK11.35261712
37TXK1.34368682
38BMPR21.32977567
39MAPK111.28886639
40HCK1.28294774
41LATS11.27454346
42KSR21.26338054
43NEK91.23137645
44ERBB41.21909308
45PHKG11.19984204
46PHKG21.19984204
47JAK11.19272332
48SYK1.18841301
49TYK21.17765014
50TIE11.17246697
51TAOK31.15755665
52FGFR21.15204130
53BTK1.13635824
54MAP2K41.12673132
55MYLK1.12395420
56GRK61.10724880
57IKBKB1.10191842
58PIK3CA1.10074415
59FRK1.09665032
60PIK3CG1.09332177
61LYN1.08635426
62TBK11.06164686
63PRKAA11.03187125
64CDC42BPA1.03133775
65EPHB11.01628172
66JAK21.01280557
67DDR20.99877336
68MAP2K30.97366251
69PTK60.96202681
70PDPK10.92844920
71YES10.92374645
72FGFR30.91399829
73MOS0.90320002
74IRAK30.89796829
75MAP3K70.89688826
76ABL20.89176355
77MET0.82642133
78LCK0.82603067
79TGFBR20.82491306
80ICK0.82316351
81MARK20.79094528
82MAP3K20.79043818
83PDK10.75383473
84MAP2K60.75022206
85DAPK20.74121065
86MAPK120.73191935
87PRKACG0.72490197
88MARK30.71539092
89KDR0.70790733
90MAP3K30.70056516
91PDGFRA0.69952606
92WNK40.68239062
93CDK60.63783528
94STK38L0.59480061
95GSK3A0.57331426
96SIK30.56688926
97CSK0.56172809
98PRKD10.54846658
99MAPK40.53446160
100RET0.53237788
101CHUK0.52862092
102MAPK70.52586354
103SGK20.52273272
104MAP2K10.52092484
105MAP3K50.52053370
106LRRK20.51320898
107NLK0.50971268
108STK100.49426664
109PRKD20.48735875
110MAP3K100.48162763
111CAMKK20.47533742
112MTOR0.46916285
113SGK30.46869151
114MAP3K140.46482519
115PRKCZ0.46442634
116MAP3K60.46044627
117PKN10.45826158
118CSF1R0.45409963
119FYN0.44306260
120KSR10.43889978
121ITK0.43627630
122HIPK20.42977300
123IKBKE0.41687737
124PTK2B0.40332069
125IGF1R0.40107150
126RAF10.40057545
127TEC0.39579935
128BMX0.39287603
129EPHA30.38358593
130PIM10.36650703
131PRKCH0.35760305
132JAK30.34891113
133STK390.34875387
134NEK10.33631660
135RPS6KL10.33548547
136RPS6KC10.33548547
137PAK30.33336788
138STK380.32864783
139IRAK10.32465243
140CDK40.31991309
141DAPK30.31842948
142STK30.31663115
143PRKCQ0.30441534
144IRAK20.29171580
145CAMK2G0.28081631
146DYRK1B0.27414413
147PBK0.25686339
148ERBB20.25173941
149PDGFRB0.24561049
150CDK90.24219527
151KIT0.23673851
152CAMK40.22011830

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.59670148
2Propanoate metabolism_Homo sapiens_hsa006403.25701084
3Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.14060611
4* Fatty acid degradation_Homo sapiens_hsa000713.12865106
5Nitrogen metabolism_Homo sapiens_hsa009103.06903476
6Osteoclast differentiation_Homo sapiens_hsa043802.86962279
7Leishmaniasis_Homo sapiens_hsa051402.86163608
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.82819896
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.79694690
10* PPAR signaling pathway_Homo sapiens_hsa033202.63712743
11* Fatty acid metabolism_Homo sapiens_hsa012122.63125775
12Arginine biosynthesis_Homo sapiens_hsa002202.58795220
13Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.53198910
14Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.52995943
15Toll-like receptor signaling pathway_Homo sapiens_hsa046202.47585101
16Tryptophan metabolism_Homo sapiens_hsa003802.46221019
172-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.45015791
18Malaria_Homo sapiens_hsa051442.28744334
19Butanoate metabolism_Homo sapiens_hsa006502.27138434
20Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.20421388
21Complement and coagulation cascades_Homo sapiens_hsa046102.17539075
22* Peroxisome_Homo sapiens_hsa041462.10943746
23NOD-like receptor signaling pathway_Homo sapiens_hsa046212.10728987
24Tuberculosis_Homo sapiens_hsa051522.07036282
25Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.03381361
26Pyruvate metabolism_Homo sapiens_hsa006201.97920372
27beta-Alanine metabolism_Homo sapiens_hsa004101.96963418
28Legionellosis_Homo sapiens_hsa051341.92743340
29NF-kappa B signaling pathway_Homo sapiens_hsa040641.81516920
30Caffeine metabolism_Homo sapiens_hsa002321.81228614
31Pentose and glucuronate interconversions_Homo sapiens_hsa000401.77884139
32Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.75166335
33Fatty acid elongation_Homo sapiens_hsa000621.74081162
34Carbon metabolism_Homo sapiens_hsa012001.74012912
35Pertussis_Homo sapiens_hsa051331.73464904
36Graft-versus-host disease_Homo sapiens_hsa053321.73219704
37Allograft rejection_Homo sapiens_hsa053301.68942844
38Staphylococcus aureus infection_Homo sapiens_hsa051501.68490307
39B cell receptor signaling pathway_Homo sapiens_hsa046621.67432628
40TNF signaling pathway_Homo sapiens_hsa046681.66919977
41Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.64628439
42Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.58880494
43RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.58461567
44Influenza A_Homo sapiens_hsa051641.53791512
45Measles_Homo sapiens_hsa051621.50626434
46Other glycan degradation_Homo sapiens_hsa005111.49671499
47Phenylalanine metabolism_Homo sapiens_hsa003601.47758355
48Toxoplasmosis_Homo sapiens_hsa051451.46500085
49Chemical carcinogenesis_Homo sapiens_hsa052041.45785573
50Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.45637521
51Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.45327341
52Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.44665292
53Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.44426555
54Histidine metabolism_Homo sapiens_hsa003401.42417842
55African trypanosomiasis_Homo sapiens_hsa051431.40530851
56* Fatty acid biosynthesis_Homo sapiens_hsa000611.38651034
57Acute myeloid leukemia_Homo sapiens_hsa052211.37790692
58Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.36645741
59Fat digestion and absorption_Homo sapiens_hsa049751.36370880
60Autoimmune thyroid disease_Homo sapiens_hsa053201.35824303
61Tyrosine metabolism_Homo sapiens_hsa003501.30937050
62Jak-STAT signaling pathway_Homo sapiens_hsa046301.30794087
63Steroid hormone biosynthesis_Homo sapiens_hsa001401.30733842
64Rheumatoid arthritis_Homo sapiens_hsa053231.30430865
65Chemokine signaling pathway_Homo sapiens_hsa040621.29883555
66Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.28668771
67Glycerolipid metabolism_Homo sapiens_hsa005611.27374743
68Retinol metabolism_Homo sapiens_hsa008301.27036425
69Starch and sucrose metabolism_Homo sapiens_hsa005001.26907676
70Hematopoietic cell lineage_Homo sapiens_hsa046401.24575467
71Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.24139559
72Phagosome_Homo sapiens_hsa041451.21992830
73Drug metabolism - other enzymes_Homo sapiens_hsa009831.21540153
74Biosynthesis of amino acids_Homo sapiens_hsa012301.19532097
75Bile secretion_Homo sapiens_hsa049761.18306800
76Lysosome_Homo sapiens_hsa041421.17639383
77Salmonella infection_Homo sapiens_hsa051321.17506043
78Type I diabetes mellitus_Homo sapiens_hsa049401.16725502
79Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.16705524
80ABC transporters_Homo sapiens_hsa020101.14430525
81Selenocompound metabolism_Homo sapiens_hsa004501.12037849
82Sulfur metabolism_Homo sapiens_hsa009201.09632318
83Herpes simplex infection_Homo sapiens_hsa051680.98995612
84Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.98987041
85Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.96735895
86Vitamin B6 metabolism_Homo sapiens_hsa007500.95900880
87T cell receptor signaling pathway_Homo sapiens_hsa046600.95700531
88Cysteine and methionine metabolism_Homo sapiens_hsa002700.94093363
89Asthma_Homo sapiens_hsa053100.93433839
90Prolactin signaling pathway_Homo sapiens_hsa049170.93425207
91Viral myocarditis_Homo sapiens_hsa054160.92531515
92Hepatitis B_Homo sapiens_hsa051610.92376691
93Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.90880267
94Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.90270753
95Lysine degradation_Homo sapiens_hsa003100.88312789
96AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.88103284
97Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.85981167
98Antigen processing and presentation_Homo sapiens_hsa046120.85298488
99Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.83340272
100Intestinal immune network for IgA production_Homo sapiens_hsa046720.82690735
101Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.79267574
102VEGF signaling pathway_Homo sapiens_hsa043700.77412481
103Folate biosynthesis_Homo sapiens_hsa007900.76118829
104Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.75968446
105* Adipocytokine signaling pathway_Homo sapiens_hsa049200.75964118
106Arginine and proline metabolism_Homo sapiens_hsa003300.75908673
107Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.74394994
108Sulfur relay system_Homo sapiens_hsa041220.73746415
109Leukocyte transendothelial migration_Homo sapiens_hsa046700.73136609
110Platelet activation_Homo sapiens_hsa046110.70935830
111Steroid biosynthesis_Homo sapiens_hsa001000.70319038
112Apoptosis_Homo sapiens_hsa042100.69234592
113Pentose phosphate pathway_Homo sapiens_hsa000300.68989635
114Shigellosis_Homo sapiens_hsa051310.66403712
115Insulin resistance_Homo sapiens_hsa049310.65572378
116Primary immunodeficiency_Homo sapiens_hsa053400.65326562
117Non-small cell lung cancer_Homo sapiens_hsa052230.65178478
118Pancreatic cancer_Homo sapiens_hsa052120.63391192
119FoxO signaling pathway_Homo sapiens_hsa040680.59780225
120Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.59633253
121Vitamin digestion and absorption_Homo sapiens_hsa049770.59532007
122Neurotrophin signaling pathway_Homo sapiens_hsa047220.59280855
123Chronic myeloid leukemia_Homo sapiens_hsa052200.58723723
124Renal cell carcinoma_Homo sapiens_hsa052110.55237173
125AMPK signaling pathway_Homo sapiens_hsa041520.54736714
126Sphingolipid signaling pathway_Homo sapiens_hsa040710.51613995
127Glutathione metabolism_Homo sapiens_hsa004800.51565566
128HIF-1 signaling pathway_Homo sapiens_hsa040660.49184703
129Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.48792390
130Dorso-ventral axis formation_Homo sapiens_hsa043200.46903106
131Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.44962897
132Glucagon signaling pathway_Homo sapiens_hsa049220.44434659
133* Metabolic pathways_Homo sapiens_hsa011000.43536477
134Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.43495381
135Cyanoamino acid metabolism_Homo sapiens_hsa004600.42317783
136Phospholipase D signaling pathway_Homo sapiens_hsa040720.41266657
137GnRH signaling pathway_Homo sapiens_hsa049120.39288475
138alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.38264377
139Maturity onset diabetes of the young_Homo sapiens_hsa049500.37727694
140Fructose and mannose metabolism_Homo sapiens_hsa000510.37269064
141Galactose metabolism_Homo sapiens_hsa000520.36906653
142Glycerophospholipid metabolism_Homo sapiens_hsa005640.33846115
143mTOR signaling pathway_Homo sapiens_hsa041500.32183529
144Notch signaling pathway_Homo sapiens_hsa043300.31127231
145Insulin signaling pathway_Homo sapiens_hsa049100.29889563
146Linoleic acid metabolism_Homo sapiens_hsa005910.22204827
147Prion diseases_Homo sapiens_hsa050200.21173020
148One carbon pool by folate_Homo sapiens_hsa006700.10126701
149Central carbon metabolism in cancer_Homo sapiens_hsa052300.07895582
150Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.07091089
151Longevity regulating pathway - mammal_Homo sapiens_hsa042110.04456545
152Type II diabetes mellitus_Homo sapiens_hsa049300.02732379
153Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.02688370
154Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410-0.1407667
155Dilated cardiomyopathy_Homo sapiens_hsa05414-0.1402707
156Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1388315
157Renin-angiotensin system_Homo sapiens_hsa04614-0.1353984
158Hepatitis C_Homo sapiens_hsa05160-0.1209071
159Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1185230
160Protein digestion and absorption_Homo sapiens_hsa04974-0.1175161
161Cardiac muscle contraction_Homo sapiens_hsa04260-0.0888745
162Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0849985
163Alzheimers disease_Homo sapiens_hsa05010-0.0791486
164Parkinsons disease_Homo sapiens_hsa05012-0.0692592
165Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0626485
166Amoebiasis_Homo sapiens_hsa05146-0.0502629
167Oxidative phosphorylation_Homo sapiens_hsa00190-0.0336795

Most similar genes based on co-expression Upload to Enrichr

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