ACSL3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in brain, and preferentially utilizes myristate, arachidonate, and eicosapentaenoate as substrates. The amino acid sequence of this isozyme is 92% identical to that of rat homolog. Two transcript variants encoding the same protein have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)7.57108395
2axon ensheathment in central nervous system (GO:0032291)7.57108395
3L-amino acid import (GO:0043092)5.57780017
4amino acid import (GO:0043090)4.91353300
5myelination (GO:0042552)4.66490727
6ensheathment of neurons (GO:0007272)4.60871596
7axon ensheathment (GO:0008366)4.60871596
8locomotory exploration behavior (GO:0035641)4.58649273
9fatty acid elongation (GO:0030497)4.51714000
10L-serine transport (GO:0015825)4.25834349
11C4-dicarboxylate transport (GO:0015740)4.05730451
12transmission of nerve impulse (GO:0019226)4.04811786
13neuron cell-cell adhesion (GO:0007158)3.94819383
14cellular potassium ion homeostasis (GO:0030007)3.87375740
15cholesterol biosynthetic process (GO:0006695)3.86032349
16gamma-aminobutyric acid transport (GO:0015812)3.84737300
17oligodendrocyte differentiation (GO:0048709)3.68079865
18nuclear pore complex assembly (GO:0051292)3.67649475
19COPI coating of Golgi vesicle (GO:0048205)3.63562886
20Golgi transport vesicle coating (GO:0048200)3.63562886
21peripheral nervous system axon ensheathment (GO:0032292)3.62251140
22myelination in peripheral nervous system (GO:0022011)3.62251140
23negative regulation of astrocyte differentiation (GO:0048712)3.59380081
24neurotransmitter uptake (GO:0001504)3.51421762
25synaptic vesicle maturation (GO:0016188)3.51306193
26layer formation in cerebral cortex (GO:0021819)3.50532489
27serine transport (GO:0032329)3.49069085
28neuronal action potential propagation (GO:0019227)3.48923628
29alanine transport (GO:0032328)3.48306991
30cellular response to cholesterol (GO:0071397)3.48262991
31regulation of short-term neuronal synaptic plasticity (GO:0048172)3.46886252
32sodium ion export (GO:0071436)3.45755091
33biotin metabolic process (GO:0006768)3.40841894
34presynaptic membrane assembly (GO:0097105)3.37065532
35regulation of cholesterol biosynthetic process (GO:0045540)3.36076641
36cerebellar granule cell differentiation (GO:0021707)3.31642739
37sterol biosynthetic process (GO:0016126)3.30606675
38negative regulation of neurotransmitter transport (GO:0051589)3.29875740
39asymmetric protein localization (GO:0008105)3.29313480
40fatty-acyl-CoA biosynthetic process (GO:0046949)3.28262656
41COPII vesicle coating (GO:0048208)3.25761902
42hemidesmosome assembly (GO:0031581)3.25740738
43desmosome organization (GO:0002934)3.25096768
44dendritic spine morphogenesis (GO:0060997)3.23367649
45dendrite morphogenesis (GO:0048813)3.22980445
46synaptic vesicle exocytosis (GO:0016079)3.22181564
47glutamate secretion (GO:0014047)3.20158575
48negative regulation of neurotransmitter secretion (GO:0046929)3.19438766
49presynaptic membrane organization (GO:0097090)3.18974299
50eye photoreceptor cell differentiation (GO:0001754)3.18895330
51photoreceptor cell differentiation (GO:0046530)3.18895330
52acidic amino acid transport (GO:0015800)3.17710140
53positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.13337768
54regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.13065850
55nuclear pore organization (GO:0006999)3.12687586
56cellular sodium ion homeostasis (GO:0006883)3.11331280
57negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.10626793
58potassium ion import (GO:0010107)3.09853715
59cerebral cortex radially oriented cell migration (GO:0021799)3.09769276
60apical protein localization (GO:0045176)3.07635809
61response to auditory stimulus (GO:0010996)3.06215187
62positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.05575162
63negative regulation of fibrinolysis (GO:0051918)3.05281781
64glutamate receptor signaling pathway (GO:0007215)3.04232439
65neuronal ion channel clustering (GO:0045161)3.03653550
66G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.03484050
67ionotropic glutamate receptor signaling pathway (GO:0035235)3.03466837
68neuroblast proliferation (GO:0007405)3.02891489
69long-chain fatty acid biosynthetic process (GO:0042759)3.02683876
70cell adhesion mediated by integrin (GO:0033627)3.02140291
71potassium ion homeostasis (GO:0055075)3.02123455
72positive regulation of dendritic spine morphogenesis (GO:0061003)3.01989941
73neurotransmitter-gated ion channel clustering (GO:0072578)3.01323637
74embryonic retina morphogenesis in camera-type eye (GO:0060059)3.01172918
75positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.01157591
76exploration behavior (GO:0035640)3.00243238
77cytoskeletal anchoring at plasma membrane (GO:0007016)2.99658138
78axonal fasciculation (GO:0007413)2.99381085
79long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.96739912
80maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.96722524
81regulation of cholesterol homeostasis (GO:2000188)2.96592797
82regulation of apoptotic cell clearance (GO:2000425)2.96584772
83neuron recognition (GO:0008038)2.95195302
84auditory behavior (GO:0031223)2.94710018
85L-glutamate transport (GO:0015813)2.94423958
86regulation of beta-amyloid formation (GO:1902003)2.90441800
87paraxial mesoderm development (GO:0048339)2.89359337
88cellular response to sterol (GO:0036315)2.87167642
89regulation of neuronal synaptic plasticity (GO:0048168)2.86879015
90myelin maintenance (GO:0043217)2.86352196
91adult walking behavior (GO:0007628)2.84226189
92regulation of synaptic vesicle exocytosis (GO:2000300)2.83119142
93synaptic transmission, glutamatergic (GO:0035249)2.82319133
94vocalization behavior (GO:0071625)2.82175965
95negative regulation of protein localization to cell surface (GO:2000009)2.80728118
96glycerophospholipid catabolic process (GO:0046475)2.80122418
97membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.78314831
98* very-low-density lipoprotein particle assembly (GO:0034379)2.77572098
99alpha-linolenic acid metabolic process (GO:0036109)2.76912290
100negative regulation of synaptic transmission, GABAergic (GO:0032229)2.75535057
101protein retention in ER lumen (GO:0006621)2.75037894
102regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.74234487
103negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.74153438
104thioester biosynthetic process (GO:0035384)2.73086948
105acyl-CoA biosynthetic process (GO:0071616)2.73086948
106pore complex assembly (GO:0046931)2.71132840
107substantia nigra development (GO:0021762)2.70852185
108positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.69659714
109astrocyte development (GO:0014002)2.69058956
110regulation of collateral sprouting (GO:0048670)2.68706654
111establishment of mitochondrion localization (GO:0051654)2.67516358
112import into cell (GO:0098657)2.67201914
113intestinal cholesterol absorption (GO:0030299)2.67030966
114* plasma lipoprotein particle assembly (GO:0034377)2.66881321
115isoprenoid biosynthetic process (GO:0008299)2.66809900
116protein carboxylation (GO:0018214)2.64842178
117peptidyl-glutamic acid carboxylation (GO:0017187)2.64842178
118regulation of long-term neuronal synaptic plasticity (GO:0048169)2.64710003
119regulation of amyloid precursor protein catabolic process (GO:1902991)2.63765728
120protein localization to synapse (GO:0035418)2.62917998
121bundle of His cell to Purkinje myocyte communication (GO:0086069)2.62669965
122neuron-neuron synaptic transmission (GO:0007270)2.62218379
123regulation of astrocyte differentiation (GO:0048710)2.61867802
124retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.60757680
125long-term synaptic potentiation (GO:0060291)2.58813114
126cell communication by electrical coupling (GO:0010644)2.58377684
127neuromuscular process controlling balance (GO:0050885)2.58011769
128lens fiber cell development (GO:0070307)2.57332799
129response to lipoprotein particle (GO:0055094)2.56148926
130notochord development (GO:0030903)2.55476178
131mitotic chromosome condensation (GO:0007076)2.55438641
132regulation of voltage-gated calcium channel activity (GO:1901385)2.53943075
133negative regulation of axonogenesis (GO:0050771)2.53592183
134long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.53315907
135vesicle coating (GO:0006901)2.50247657
136basement membrane organization (GO:0071711)2.49669620
137regulation of fibrinolysis (GO:0051917)2.48588241
138positive regulation of hormone biosynthetic process (GO:0046886)2.46591080
139* protein-lipid complex assembly (GO:0065005)2.45996464
140gap junction assembly (GO:0016264)2.44989058
141mitotic sister chromatid cohesion (GO:0007064)2.44206559
142dicarboxylic acid biosynthetic process (GO:0043650)2.43464240
143regulation of protein activation cascade (GO:2000257)2.35083391
144positive regulation of hormone metabolic process (GO:0032352)2.34181509
145regulation of complement activation (GO:0030449)2.31049507
146mitotic cytokinesis (GO:0000281)2.30468287
147cholesterol efflux (GO:0033344)2.30072487
148retina vasculature morphogenesis in camera-type eye (GO:0061299)2.29759444
1494-hydroxyproline metabolic process (GO:0019471)2.28853845
150regulation of plasminogen activation (GO:0010755)2.28733445
151nucleotide-sugar biosynthetic process (GO:0009226)2.23781049
152G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.22720606
153positive regulation of cell cycle checkpoint (GO:1901978)2.22223850
154polarized epithelial cell differentiation (GO:0030859)2.22118724
155hippo signaling (GO:0035329)2.22061686
156cellular copper ion homeostasis (GO:0006878)2.21843974
157peptidyl-proline hydroxylation (GO:0019511)2.20835774
158proline biosynthetic process (GO:0006561)2.16144131
159low-density lipoprotein particle remodeling (GO:0034374)2.16071758
160negative regulation of keratinocyte proliferation (GO:0010839)2.15594001
161iron ion import (GO:0097286)2.14669399
162fatty-acyl-CoA metabolic process (GO:0035337)2.14090985
163regulation of mitotic spindle organization (GO:0060236)2.13782634
164low-density lipoprotein particle clearance (GO:0034383)2.11996599
165protein hydroxylation (GO:0018126)2.11593477
166NLS-bearing protein import into nucleus (GO:0006607)2.09110580
167coenzyme A metabolic process (GO:0015936)2.08230001
168regulation of translational fidelity (GO:0006450)2.08098490
169negative regulation of DNA repair (GO:0045738)2.07477067
170anterior/posterior axis specification, embryo (GO:0008595)2.07444828
171epithelial tube branching involved in lung morphogenesis (GO:0060441)2.06664277
172branching involved in prostate gland morphogenesis (GO:0060442)2.05182853
173ectodermal placode formation (GO:0060788)2.05042418
174sister chromatid segregation (GO:0000819)2.04345922
175cell-substrate junction assembly (GO:0007044)2.04306193
176glutamate metabolic process (GO:0006536)2.03693447
177regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.03642180
178linoleic acid metabolic process (GO:0043651)2.02626722
179activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.02201889
180chondrocyte proliferation (GO:0035988)2.01083193
181regulation of sister chromatid cohesion (GO:0007063)2.00454583
182skin morphogenesis (GO:0043589)2.00430773
183intestinal absorption (GO:0050892)2.00027979
184positive regulation of nuclease activity (GO:0032075)1.99018745
185cytoskeleton-dependent cytokinesis (GO:0061640)1.98041965
186regulation of steroid hormone biosynthetic process (GO:0090030)1.97403621
187regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)1.96983656
188acetyl-CoA metabolic process (GO:0006084)1.96729447
189establishment of apical/basal cell polarity (GO:0035089)1.96118628

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* AR_21909140_ChIP-Seq_LNCAP_Human4.61521374
2TP63_17297297_ChIP-ChIP_HaCaT_Human4.42053985
3EZH2_22144423_ChIP-Seq_EOC_Human3.67330655
4E2F7_22180533_ChIP-Seq_HELA_Human3.36802532
5GBX2_23144817_ChIP-Seq_PC3_Human3.12178979
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.97895379
7ZNF263_19887448_ChIP-Seq_K562_Human2.97305279
8RBPJ_22232070_ChIP-Seq_NCS_Mouse2.94936497
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.80496762
10FOXM1_23109430_ChIP-Seq_U2OS_Human2.80359281
11JARID2_20064375_ChIP-Seq_MESCs_Mouse2.76579197
12CLOCK_20551151_ChIP-Seq_293T_Human2.74449647
13TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.64619566
14RNF2_18974828_ChIP-Seq_MESCs_Mouse2.51134660
15EZH2_18974828_ChIP-Seq_MESCs_Mouse2.51134660
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.48434277
17PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.48005850
18* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.46915315
19ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.42879346
20SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.35885024
21AR_21572438_ChIP-Seq_LNCaP_Human2.35484147
22EED_16625203_ChIP-ChIP_MESCs_Mouse2.35413533
23SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.32208730
24MTF2_20144788_ChIP-Seq_MESCs_Mouse2.31994630
25EZH2_27304074_Chip-Seq_ESCs_Mouse2.30241629
26SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.28281507
27JARID2_20075857_ChIP-Seq_MESCs_Mouse2.26216117
28NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.20271393
29RNF2_27304074_Chip-Seq_ESCs_Mouse2.16509948
30SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.15607960
31SALL1_21062744_ChIP-ChIP_HESCs_Human2.06826118
32DROSHA_22980978_ChIP-Seq_HELA_Human2.06395966
33EZH2_27294783_Chip-Seq_ESCs_Mouse2.03553251
34SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.02812865
35SUZ12_27294783_Chip-Seq_ESCs_Mouse1.96500022
36ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.94491333
37HIF1A_21447827_ChIP-Seq_MCF-7_Human1.93402086
38NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.90622785
39REST_21632747_ChIP-Seq_MESCs_Mouse1.87298337
40* FOXA2_19822575_ChIP-Seq_HepG2_Human1.79504834
41SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.78634297
42RARB_27405468_Chip-Seq_BRAIN_Mouse1.76697760
43CTBP1_25329375_ChIP-Seq_LNCAP_Human1.72456590
44SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.71214274
45CTBP2_25329375_ChIP-Seq_LNCAP_Human1.69987428
46ESR1_15608294_ChIP-ChIP_MCF-7_Human1.69561963
47RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.65603988
48ESR2_21235772_ChIP-Seq_MCF-7_Human1.62739521
49OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.62291580
50POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.60931950
51WT1_19549856_ChIP-ChIP_CCG9911_Human1.60869916
52SALL4_18804426_ChIP-ChIP_XEN_Mouse1.58047539
53FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.56857949
54ERG_21242973_ChIP-ChIP_JURKAT_Human1.55652480
55CBX2_27304074_Chip-Seq_ESCs_Mouse1.54924203
56CDX2_19796622_ChIP-Seq_MESCs_Mouse1.53743909
57SMAD3_21741376_ChIP-Seq_EPCs_Human1.52988609
58PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.51984413
59ZFX_18555785_ChIP-Seq_MESCs_Mouse1.49540886
60REST_18959480_ChIP-ChIP_MESCs_Mouse1.45970509
61* PIAS1_25552417_ChIP-Seq_VCAP_Human1.44046564
62TAF15_26573619_Chip-Seq_HEK293_Human1.43707425
63SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.42743998
64PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.40854394
65GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40037134
66EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.39453067
67RING1B_27294783_Chip-Seq_ESCs_Mouse1.38975571
68SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37251826
69ESR1_21235772_ChIP-Seq_MCF-7_Human1.34034415
70P300_19829295_ChIP-Seq_ESCs_Human1.33447432
71NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.32998571
72TRIM28_21343339_ChIP-Seq_HEK293_Human1.32665535
73CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.31896551
74MYCN_18555785_ChIP-Seq_MESCs_Mouse1.30964364
75CTNNB1_20460455_ChIP-Seq_HCT116_Human1.30525321
76SMAD4_21799915_ChIP-Seq_A2780_Human1.30496350
77SOX17_20123909_ChIP-Seq_XEN_Mouse1.29691601
78GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.29635889
79SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.29468929
80ZFP57_27257070_Chip-Seq_ESCs_Mouse1.29387163
81RING1B_27294783_Chip-Seq_NPCs_Mouse1.29288284
82* TCF4_18268006_ChIP-ChIP_LS174T_Human1.28699381
83NELFA_20434984_ChIP-Seq_ESCs_Mouse1.27087807
84PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.26954424
85FUS_26573619_Chip-Seq_HEK293_Human1.26480397
86TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24624963
87NANOG_21062744_ChIP-ChIP_HESCs_Human1.24483359
88* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.24357486
89SOX2_21211035_ChIP-Seq_LN229_Gbm1.24198257
90WT1_25993318_ChIP-Seq_PODOCYTE_Human1.23954649
91STAT3_23295773_ChIP-Seq_U87_Human1.23591840
92SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.23414001
93ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.22934940
94TP53_16413492_ChIP-PET_HCT116_Human1.22307385
95NR3C1_21868756_ChIP-Seq_MCF10A_Human1.20845781
96PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18894533
97EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.18616719
98ZNF274_21170338_ChIP-Seq_K562_Hela1.18340501
99LXR_22158963_ChIP-Seq_LIVER_Mouse1.18179916
100SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.17526186
101SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.17526186
102RXR_22158963_ChIP-Seq_LIVER_Mouse1.17379588
103POU3F2_20337985_ChIP-ChIP_501MEL_Human1.17208426
104MYC_18555785_ChIP-Seq_MESCs_Mouse1.17002315
105TOP2B_26459242_ChIP-Seq_MCF-7_Human1.16980364
106CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.15808604
107* HNF4A_19822575_ChIP-Seq_HepG2_Human1.15224866
108AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.15069570
109* CHD1_26751641_Chip-Seq_LNCaP_Human1.14165297
110ESR1_20079471_ChIP-ChIP_T-47D_Human1.13481631
111KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.13210872
112PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.13093669
113CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.12446942
114IKZF1_21737484_ChIP-ChIP_HCT116_Human1.11603868
115* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.11405926
116MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.11381671
117* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.11242984
118DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.10924552
119KLF4_18555785_ChIP-Seq_MESCs_Mouse1.10461563
120TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.10346917
121HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.10203021
122CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.09581818
123ER_23166858_ChIP-Seq_MCF-7_Human1.09119121
124FOXO3_23340844_ChIP-Seq_DLD1_Human1.08826521
125SOX2_27498859_Chip-Seq_STOMACH_Mouse1.08740136
126NR3C1_23031785_ChIP-Seq_PC12_Mouse1.08731877
127WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.08206331
128TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.08090318
129* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.07943752
130STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.07732451
131TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06862405
132TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.06604110
133FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.06399970
134FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.06180228
135AR_19668381_ChIP-Seq_PC3_Human1.05627431
136MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.04990670
137EP300_21415370_ChIP-Seq_HL-1_Mouse1.04807820
138* AR_25329375_ChIP-Seq_VCAP_Human1.04713928
139E2F1_21310950_ChIP-Seq_MCF-7_Human1.04621447
140POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.03917686
141TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03917686
142DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.03795274
143* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.02811911
144LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02551755
145E2F4_17652178_ChIP-ChIP_JURKAT_Human1.02119051
146* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.02112411
147CDX2_20551321_ChIP-Seq_CACO-2_Human1.01162465
148ARNT_22903824_ChIP-Seq_MCF-7_Human1.01135763
149TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.00491269
150* TCF4_23295773_ChIP-Seq_U87_Human1.00306828
151YAP1_20516196_ChIP-Seq_MESCs_Mouse0.99943257
152GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.99839533
153RXR_22108803_ChIP-Seq_LS180_Human0.99651042
154* RUNX2_22187159_ChIP-Seq_PCA_Human0.99129099
155HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.99083745
156P53_22127205_ChIP-Seq_FIBROBLAST_Human0.98886876
157EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.98648941
158* NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.97906526
159MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.97871549
160FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.97832575
161AHR_22903824_ChIP-Seq_MCF-7_Human0.97008484
162MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.96695120
163NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.96687695
164ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.96305904
165GATA6_25053715_ChIP-Seq_YYC3_Human0.96181712
166TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.95992071
167ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.95660194
168PADI4_21655091_ChIP-ChIP_MCF-7_Human0.94866199
169TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.94534541
170RNF2_27304074_Chip-Seq_NSC_Mouse0.94454885
171SOX2_20726797_ChIP-Seq_SW620_Human0.94437124
172TP53_18474530_ChIP-ChIP_U2OS_Human0.93900281
173NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.93841673
174NRF2_20460467_ChIP-Seq_MEFs_Mouse0.93841673
175NANOG_18555785_Chip-Seq_ESCs_Mouse0.93777662
176UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.93467553
177NFIB_24661679_ChIP-Seq_LUNG_Mouse0.93382711
178SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.93313724
179EOMES_21245162_ChIP-Seq_HESCs_Human0.92123465
180* GATA3_24758297_ChIP-Seq_MCF-7_Human0.91831668
181CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.91782457
182SMAD3_21741376_ChIP-Seq_ESCs_Human0.91353417
183POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.90957796
184BMI1_23680149_ChIP-Seq_NPCS_Mouse0.90425191
185* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.88546869
186VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.88369334
187TBL1_22424771_ChIP-Seq_293T_Human0.88007106

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity3.89232815
2MP0004270_analgesia3.50663663
3MP0004885_abnormal_endolymph3.44751787
4MP0003880_abnormal_central_pattern3.41648294
5MP0003941_abnormal_skin_development3.21058280
6MP0003122_maternal_imprinting3.07047402
7MP0001486_abnormal_startle_reflex2.92338526
8MP0003329_amyloid_beta_deposits2.89311691
9MP0003690_abnormal_glial_cell2.84018710
10MP0010234_abnormal_vibrissa_follicle2.77125307
11MP0003635_abnormal_synaptic_transmissio2.76351634
12MP0000920_abnormal_myelination2.68489958
13MP0001485_abnormal_pinna_reflex2.61878129
14MP0005423_abnormal_somatic_nervous2.58722856
15MP0009046_muscle_twitch2.48967512
16MP0002064_seizures2.45994505
17MP0003890_abnormal_embryonic-extraembry2.40642001
18MP0003123_paternal_imprinting2.36523749
19MP0004272_abnormal_basement_membrane2.34141686
20MP0009745_abnormal_behavioral_response2.29462529
21MP0002272_abnormal_nervous_system2.23538704
22MP0000778_abnormal_nervous_system2.18022430
23MP0003566_abnormal_cell_adhesion2.12368750
24MP0002063_abnormal_learning/memory/cond2.11652532
25MP0003136_yellow_coat_color2.04677296
26MP0005171_absent_coat_pigmentation2.04213356
27MP0002572_abnormal_emotion/affect_behav2.00310375
28MP0003634_abnormal_glial_cell1.97226265
29MP0002734_abnormal_mechanical_nocicepti1.97136515
30MP0001440_abnormal_grooming_behavior1.96484202
31MP0003878_abnormal_ear_physiology1.85926886
32MP0005377_hearing/vestibular/ear_phenot1.85926886
33MP0005551_abnormal_eye_electrophysiolog1.83556606
34MP0005257_abnormal_intraocular_pressure1.77882775
35MP0004742_abnormal_vestibular_system1.74282607
36MP0004264_abnormal_extraembryonic_tissu1.72120511
37MP0005076_abnormal_cell_differentiation1.69819527
38MP0009780_abnormal_chondrocyte_physiolo1.69675139
39MP0003632_abnormal_nervous_system1.69669120
40MP0000537_abnormal_urethra_morphology1.67528702
41MP0001963_abnormal_hearing_physiology1.64587873
42MP0005408_hypopigmentation1.63779346
43MP0003705_abnormal_hypodermis_morpholog1.63007252
44MP0004142_abnormal_muscle_tone1.62870243
45MP0008569_lethality_at_weaning1.60475019
46MP0008438_abnormal_cutaneous_collagen1.56820571
47MP0002882_abnormal_neuron_morphology1.56620983
48MP0001915_intracranial_hemorrhage1.53903644
49MP0000678_abnormal_parathyroid_gland1.52639568
50MP0002139_abnormal_hepatobiliary_system1.52388700
51MP0002067_abnormal_sensory_capabilities1.51896042
52MP0003950_abnormal_plasma_membrane1.49684854
53MP0001905_abnormal_dopamine_level1.49540714
54MP0000955_abnormal_spinal_cord1.49508967
55MP0004185_abnormal_adipocyte_glucose1.47407027
56MP0002229_neurodegeneration1.47049959
57MP0002089_abnormal_postnatal_growth/wei1.44131781
58MP0001968_abnormal_touch/_nociception1.43937753
59MP0004858_abnormal_nervous_system1.43719194
60MP0003385_abnormal_body_wall1.43275644
61MP0000566_synostosis1.42948324
62MP0001529_abnormal_vocalization1.42737352
63MP0001299_abnormal_eye_distance/1.42303188
64MP0000462_abnormal_digestive_system1.40780785
65MP0003315_abnormal_perineum_morphology1.40772192
66MP0010352_gastrointestinal_tract_polyps1.40123823
67MP0002733_abnormal_thermal_nociception1.38314689
68MP0003121_genomic_imprinting1.37929264
69MP0000762_abnormal_tongue_morphology1.35622434
70MP0005386_behavior/neurological_phenoty1.35245587
71MP0004924_abnormal_behavior1.35245587
72MP0002877_abnormal_melanocyte_morpholog1.35157630
73MP0005253_abnormal_eye_physiology1.34621655
74MP0006072_abnormal_retinal_apoptosis1.34553951
75MP0003631_nervous_system_phenotype1.33923086
76MP0001502_abnormal_circadian_rhythm1.32594192
77MP0002697_abnormal_eye_size1.32449012
78MP0000026_abnormal_inner_ear1.32121915
79MP0004957_abnormal_blastocyst_morpholog1.31278286
80MP0005646_abnormal_pituitary_gland1.30933774
81MP0005623_abnormal_meninges_morphology1.30697435
82MP0000604_amyloidosis1.30408977
83MP0001970_abnormal_pain_threshold1.27465817
84MP0002557_abnormal_social/conspecific_i1.27419139
85MP0003633_abnormal_nervous_system1.27235415
86MP0002752_abnormal_somatic_nervous1.26970042
87MP0002184_abnormal_innervation1.26525847
88MP0001730_embryonic_growth_arrest1.26007066
89MP0002909_abnormal_adrenal_gland1.25783483
90MP0002066_abnormal_motor_capabilities/c1.25407093
91MP0003868_abnormal_feces_composition1.24825264
92MP0002152_abnormal_brain_morphology1.20199496
93MP0009672_abnormal_birth_weight1.19289765
94MP0003942_abnormal_urinary_system1.18930711
95MP0005380_embryogenesis_phenotype1.17824910
96MP0001672_abnormal_embryogenesis/_devel1.17824910
97MP0002090_abnormal_vision1.16019157
98MP0001501_abnormal_sleep_pattern1.13613756
99MP0002938_white_spotting1.12424055
100MP0001984_abnormal_olfaction1.12091279
101MP0006054_spinal_hemorrhage1.11906424
102MP0003984_embryonic_growth_retardation1.11607940
103MP0005195_abnormal_posterior_eye1.11329448
104MP0009384_cardiac_valve_regurgitation1.10344715
105MP0003011_delayed_dark_adaptation1.08879045
106MP0008932_abnormal_embryonic_tissue1.08755128
107MP0002088_abnormal_embryonic_growth/wei1.08720401
108MP0010678_abnormal_skin_adnexa1.08256173
109MP0001177_atelectasis1.07207586
110MP0004134_abnormal_chest_morphology1.07086190
111MP0003111_abnormal_nucleus_morphology1.07039654
112MP0002084_abnormal_developmental_patter1.06635681
113MP0003938_abnormal_ear_development1.06483723
114MP0002736_abnormal_nociception_after1.05683967
115MP0001666_abnormal_nutrient_absorption1.05549217
116MP0002896_abnormal_bone_mineralization1.05210203
117MP0005248_abnormal_Harderian_gland1.02566784
118MP0002086_abnormal_extraembryonic_tissu1.00862293
119MP0002233_abnormal_nose_morphology1.00167946
120MP0004197_abnormal_fetal_growth/weight/0.99771153
121MP0003115_abnormal_respiratory_system0.99277003
122MP0003935_abnormal_craniofacial_develop0.98144678
123MP0003755_abnormal_palate_morphology0.98073851
124MP0002234_abnormal_pharynx_morphology0.97665791
125MP0003937_abnormal_limbs/digits/tail_de0.96372767
126MP0001697_abnormal_embryo_size0.96344695
127MP0009697_abnormal_copulation0.94771610
128MP0004043_abnormal_pH_regulation0.93830544
129MP0005451_abnormal_body_composition0.92848523
130MP0003137_abnormal_impulse_conducting0.92457990
131MP0005187_abnormal_penis_morphology0.91637019
132MP0009703_decreased_birth_body0.90254610
133MP0002822_catalepsy0.90014086
134MP0002085_abnormal_embryonic_tissue0.89811474
135MP0000383_abnormal_hair_follicle0.88577892
136MP0002092_abnormal_eye_morphology0.87971548
137MP0002080_prenatal_lethality0.87890558
138MP0003195_calcinosis0.87200898
139MP0003567_abnormal_fetal_cardiomyocyte0.86464890
140MP0002111_abnormal_tail_morphology0.84920966
141MP0002653_abnormal_ependyma_morphology0.84674834
142MP0004811_abnormal_neuron_physiology0.84176570
143MP0005409_darkened_coat_color0.83831621
144MP0003861_abnormal_nervous_system0.83778355
145MP0000631_abnormal_neuroendocrine_gland0.83465581
146MP0000579_abnormal_nail_morphology0.82802248
147MP0003879_abnormal_hair_cell0.82401652
148MP0010094_abnormal_chromosome_stability0.81795949
149MP0000647_abnormal_sebaceous_gland0.80891765
150MP0001849_ear_inflammation0.80038037
151MP0003693_abnormal_embryo_hatching0.79662809
152MP0002098_abnormal_vibrissa_morphology0.79592582
153MP0002060_abnormal_skin_morphology0.78999987
154MP0001286_abnormal_eye_development0.78520788
155MP0005365_abnormal_bile_salt0.77818851
156MP0002249_abnormal_larynx_morphology0.77479863
157MP0000432_abnormal_head_morphology0.77064234
158MP0000049_abnormal_middle_ear0.76486003
159MP0005410_abnormal_fertilization0.75035108
160MP0000534_abnormal_ureter_morphology0.74982063
161MP0002009_preneoplasia0.74647109
162MP0001661_extended_life_span0.74260905
163MP0003075_altered_response_to0.73936909
164MP0000467_abnormal_esophagus_morphology0.72810277
165MP0009250_abnormal_appendicular_skeleto0.72398709
166MP0005360_urolithiasis0.71905872
167MP0002269_muscular_atrophy0.71801160
168MP0005197_abnormal_uvea_morphology0.71729476
169MP0002796_impaired_skin_barrier0.70856490
170MP0001943_abnormal_respiration0.70596812
171MP0005391_vision/eye_phenotype0.70404667
172MP0002735_abnormal_chemical_nociception0.69906879
173MP0005645_abnormal_hypothalamus_physiol0.68365358
174MP0010030_abnormal_orbit_morphology0.68328895
175MP0002638_abnormal_pupillary_reflex0.66180884
176MP0004145_abnormal_muscle_electrophysio0.64987718
177MP0004233_abnormal_muscle_weight0.64812945

Predicted human phenotypes

RankGene SetZ-score
1Neurofibrillary tangles (HP:0002185)5.52298294
2Deep venous thrombosis (HP:0002625)4.80186819
3Aplasia involving bones of the upper limbs (HP:0009823)4.62265757
4Aplasia of the phalanges of the hand (HP:0009802)4.62265757
5Aplasia involving bones of the extremities (HP:0009825)4.62265757
6Megalencephaly (HP:0001355)4.61677740
7Cerebral inclusion bodies (HP:0100314)4.32435897
8Degeneration of the lateral corticospinal tracts (HP:0002314)4.21342501
9Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.21342501
10Focal motor seizures (HP:0011153)3.74396679
11Abnormality of the corticospinal tract (HP:0002492)3.57842284
12Myokymia (HP:0002411)3.54482189
13Supranuclear gaze palsy (HP:0000605)3.39968592
14Peripheral hypomyelination (HP:0007182)3.27503538
15Mixed hearing impairment (HP:0000410)3.26529972
16Flat acetabular roof (HP:0003180)3.23859780
17Intention tremor (HP:0002080)3.04368017
18Alacrima (HP:0000522)2.98053273
19Abnormality of carpal bone ossification (HP:0006257)2.92996148
20Hemiparesis (HP:0001269)2.90459452
21Clumsiness (HP:0002312)2.86326880
22Abnormality of glycolysis (HP:0004366)2.77322181
23Epileptic encephalopathy (HP:0200134)2.76871304
24Abnormal tarsal ossification (HP:0008369)2.75997272
25Spastic gait (HP:0002064)2.75207685
26Hypoplastic pelvis (HP:0008839)2.75207636
27Focal seizures (HP:0007359)2.74778185
28Action tremor (HP:0002345)2.73208675
29Dysmetria (HP:0001310)2.69784520
30Insidious onset (HP:0003587)2.69247623
31Termporal pattern (HP:0011008)2.69247623
32Diplopia (HP:0000651)2.64072991
33Abnormality of binocular vision (HP:0011514)2.64072991
34Small epiphyses (HP:0010585)2.64047922
35Prolonged partial thromboplastin time (HP:0003645)2.63623195
36Papillary thyroid carcinoma (HP:0002895)2.61722446
37Increased serum pyruvate (HP:0003542)2.61673384
38Asymmetry of the thorax (HP:0001555)2.56151724
39Synostosis involving the elbow (HP:0003938)2.53838506
40Humeroradial synostosis (HP:0003041)2.53838506
41Split foot (HP:0001839)2.49119163
42Morphological abnormality of the inner ear (HP:0011390)2.43282247
43Hypercholesterolemia (HP:0003124)2.42753980
44Dysdiadochokinesis (HP:0002075)2.41748075
45Akinesia (HP:0002304)2.40447693
46Abnormal foot bone ossification (HP:0010675)2.38872869
47Arterial tortuosity (HP:0005116)2.37610390
48Intrahepatic cholestasis (HP:0001406)2.36415440
49Coronal craniosynostosis (HP:0004440)2.36136860
50Scanning speech (HP:0002168)2.34598620
51Ankle clonus (HP:0011448)2.34314686
52Abnormality of the middle phalanges of the toes (HP:0010183)2.33916463
53Hypoplastic left heart (HP:0004383)2.32831941
54Abnormal hand bone ossification (HP:0010660)2.32445284
55Abnormal ossification of hand bones (HP:0005921)2.32010297
56Increased nuchal translucency (HP:0010880)2.32008711
57Hepatoblastoma (HP:0002884)2.31944752
58Epidermoid cyst (HP:0200040)2.31591468
59Right ventricular cardiomyopathy (HP:0011663)2.30957780
60Decreased lacrimation (HP:0000633)2.28495472
61Hypobetalipoproteinemia (HP:0003563)2.28429858
62Overlapping toe (HP:0001845)2.25316939
63Atonic seizures (HP:0010819)2.21364433
64Progressive cerebellar ataxia (HP:0002073)2.21280693
65Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.19254230
66Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.19166790
67Sensory axonal neuropathy (HP:0003390)2.18635330
68Parakeratosis (HP:0001036)2.16345570
69Pterygium (HP:0001059)2.14752447
70Abnormality of pain sensation (HP:0010832)2.14616580
71Impaired pain sensation (HP:0007328)2.14616580
72Epiphyseal dysplasia (HP:0002656)2.13687185
73Relative macrocephaly (HP:0004482)2.13237868
74Abnormality of the common coagulation pathway (HP:0010990)2.12387687
75Lower limb muscle weakness (HP:0007340)2.11975882
76Retinal dysplasia (HP:0007973)2.08899945
77Thickened helices (HP:0000391)2.07113912
78Microglossia (HP:0000171)2.03063420
79Septate vagina (HP:0001153)2.02776559
80Broad alveolar ridges (HP:0000187)2.01750310
81Cortical dysplasia (HP:0002539)2.01159606
82Vascular tortuosity (HP:0004948)2.01121684
83Deviation of the thumb (HP:0009603)2.00134615
84Abnormal auditory evoked potentials (HP:0006958)1.99388220
85Hemiplegia (HP:0002301)1.99128728
86Myelomeningocele (HP:0002475)1.96765083
87Advanced eruption of teeth (HP:0006288)1.96193388
88Hypoplastic heart (HP:0001961)1.94129156
89Hypoplasia of the capital femoral epiphysis (HP:0003090)1.93194086
90Abnormality of the phalanges of the 2nd finger (HP:0009541)1.92346935
91Anteriorly placed anus (HP:0001545)1.91120372
92Generalized tonic-clonic seizures (HP:0002069)1.90548629
93Abnormal eating behavior (HP:0100738)1.89976284
94Vertebral arch anomaly (HP:0008438)1.89293151
95Turricephaly (HP:0000262)1.89264901
96Nephroblastoma (Wilms tumor) (HP:0002667)1.88852509
97Increased circulating renin level (HP:0000848)1.88804758
98Postural instability (HP:0002172)1.86738122
99Missing ribs (HP:0000921)1.86209528
100Conjugated hyperbilirubinemia (HP:0002908)1.85412540
101Broad-based gait (HP:0002136)1.83540968
102Partial agenesis of the corpus callosum (HP:0001338)1.83484538
103Heterotopia (HP:0002282)1.82866340
104Embryonal renal neoplasm (HP:0011794)1.82739397
105Ankyloglossia (HP:0010296)1.82539478
106Abnormality of the nasal septum (HP:0000419)1.81878715
107Urinary bladder sphincter dysfunction (HP:0002839)1.80705406
108Hammertoe (HP:0001765)1.80198432
109Impaired vibration sensation in the lower limbs (HP:0002166)1.79158482
110Urinary urgency (HP:0000012)1.78057911
111Visual hallucinations (HP:0002367)1.77417512
112Anomalous pulmonary venous return (HP:0010772)1.77410098
113Abnormality of cochlea (HP:0000375)1.77007798
114Abnormality of secondary sexual hair (HP:0009888)1.76595180
115Abnormality of the axillary hair (HP:0100134)1.76595180
116Truncal ataxia (HP:0002078)1.75868531
117Cupped ear (HP:0000378)1.75742987
118Back pain (HP:0003418)1.75377259
119Broad palm (HP:0001169)1.74981667
120Clonus (HP:0002169)1.74860028
121Meningocele (HP:0002435)1.74815628
122Absent eyebrow (HP:0002223)1.74416947
123Bell-shaped thorax (HP:0001591)1.74269331
124Generalized myoclonic seizures (HP:0002123)1.73789065
125Bifid scrotum (HP:0000048)1.73287848
126Confusion (HP:0001289)1.72930627
127Dialeptic seizures (HP:0011146)1.72823339
128Hypolipoproteinemia (HP:0010981)1.71526124
129Acanthocytosis (HP:0001927)1.71279887
130Limited elbow extension (HP:0001377)1.71099475
131Pseudobulbar signs (HP:0002200)1.70921092
132Vascular calcification (HP:0004934)1.70834317
133Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.70509915
134Vertebral hypoplasia (HP:0008417)1.70509915
135Slow saccadic eye movements (HP:0000514)1.69951726
136Absent septum pellucidum (HP:0001331)1.69627879
137Infantile muscular hypotonia (HP:0008947)1.66170719
138Oligodactyly (hands) (HP:0001180)1.65228494
139Onion bulb formation (HP:0003383)1.65041164
140Proximal placement of thumb (HP:0009623)1.64604609
141Symphalangism affecting the phalanges of the hand (HP:0009773)1.64567888
142Wide nose (HP:0000445)1.64415252
143Esophageal atresia (HP:0002032)1.64386107
144Renal duplication (HP:0000075)1.64346651
145Abnormality of the parathyroid morphology (HP:0011766)1.64186033
146Bronchomalacia (HP:0002780)1.64020685
147Skin nodule (HP:0200036)1.63635804
148Hypoplastic nipples (HP:0002557)1.63515659
149Spastic paraparesis (HP:0002313)1.63493297
150Pheochromocytoma (HP:0002666)1.63053341
151Premature rupture of membranes (HP:0001788)1.61663407
152Hyperventilation (HP:0002883)1.61349055
153Vaginal atresia (HP:0000148)1.60745469
154Genital tract atresia (HP:0001827)1.60691898
155Short hallux (HP:0010109)1.60395089
156Neonatal death (HP:0003811)1.60133941
157Depression (HP:0000716)1.59641397
158Cardiovascular calcification (HP:0011915)1.58990401
159Abnormality of the acetabulum (HP:0003170)1.58125310
16011 pairs of ribs (HP:0000878)1.57838522
161Long nose (HP:0003189)1.57451387
162Abnormality of the lacrimal duct (HP:0011481)1.57110077
163Anal stenosis (HP:0002025)1.56608837
164Adrenal hypoplasia (HP:0000835)1.56462678
165Shallow orbits (HP:0000586)1.55919333
166Abnormal cartilage morphology (HP:0002763)1.55782606
167Exotropia (HP:0000577)1.55552522
168Pancreatic islet-cell hyperplasia (HP:0004510)1.53434799
169Hyperphosphatemia (HP:0002905)1.53351919
170Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.52904491
171Protrusio acetabuli (HP:0003179)1.51276110
172Midface retrusion (HP:0011800)1.50245594
173Bifid tongue (HP:0010297)1.50040129
174Absent eyelashes (HP:0000561)1.49730472
175Atrophic scars (HP:0001075)1.49613484
176Thyroid carcinoma (HP:0002890)1.47806615
177Glomerulonephritis (HP:0000099)1.45498708
178Uterine leiomyosarcoma (HP:0002891)1.45122982
179Leiomyosarcoma (HP:0100243)1.45122982
180Insomnia (HP:0100785)1.44292040
181Abnormality of the Achilles tendon (HP:0005109)1.44015654
182Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.43949439
183Absent epiphyses (HP:0010577)1.43949439
184Facial hemangioma (HP:0000329)1.43610352
185Tracheal stenosis (HP:0002777)1.42940502

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.09946294
2TNIK3.89862322
3STK393.77349379
4CAMK1D3.20032622
5LATS12.71713579
6OXSR12.68283792
7DDR22.40945522
8PHKG12.36396481
9PHKG22.36396481
10SCYL22.24229669
11LMTK22.23214881
12NTRK22.19079878
13MARK12.13889192
14PDGFRA2.12249329
15NTRK32.12012693
16NEK12.07766558
17TYRO32.00175606
18EIF2AK11.95336342
19MAP3K91.93446715
20CDK121.88211864
21EPHA21.88125924
22TTK1.86831069
23NTRK11.86057889
24PRKD31.83325890
25MST1R1.82255071
26FGFR41.82207756
27PNCK1.78548363
28PAK61.77578026
29EPHB11.77029213
30MAP3K41.75758708
31EEF2K1.75150604
32UHMK11.73014863
33CASK1.66860137
34CDK191.59960207
35AKT31.57191023
36ICK1.56792492
37WEE11.51345155
38FGR1.47488512
39FGFR21.47276066
40TSSK61.44228075
41MAPK131.43860644
42BCR1.43352484
43SRPK11.36290380
44WNK41.36110364
45MET1.33148701
46MUSK1.30775292
47MINK11.30151347
48PKN11.29832656
49STK38L1.28490028
50KSR21.27095516
51WNK11.26112577
52RIPK11.25631104
53PRPF4B1.21983922
54CDK51.21349891
55PKN21.19758455
56SGK2231.18255687
57SGK4941.18255687
58CSNK1G21.15989524
59NEK61.14770619
60ROCK21.14077042
61BRD41.14059664
62FGFR31.13692185
63EIF2AK31.13010416
64FER1.08647934
65TRIB31.08329797
66PAK31.03867154
67PTK21.03567399
68BRSK21.01727321
69ERBB30.99880379
70PAK40.99103444
71CAMK2B0.98677543
72CSNK1G30.96145818
73CSNK1A1L0.95663808
74BRSK10.95040507
75TAOK10.94400944
76PBK0.93980239
77CAMK2A0.93287831
78MAP2K70.92611059
79CDK140.91706510
80MAPKAPK50.91504096
81LIMK10.90531620
82PDK20.89162876
83CDK150.89128354
84TRIM280.87698913
85ERBB40.86601377
86CSNK1G10.84176107
87CDK180.84007925
88PLK30.81223815
89CAMK1G0.77369006
90CDK11A0.76827543
91CAMK2D0.76461100
92KSR10.75462837
93MARK20.75305913
94MTOR0.73973184
95CSNK1E0.73362793
96PRKCG0.71660631
97MAP3K130.71144785
98BMX0.70821248
99CDC70.70400974
100BUB10.70251693
101IRAK30.69919901
102CAMK2G0.67521513
103PLK20.64530268
104MAP3K20.64206660
105SIK10.64036563
106CDK70.63641657
107CDK60.63249190
108PRKCE0.61934173
109YES10.61766450
110MAP2K40.61038972
111ROCK10.60787448
112DYRK1A0.60135491
113FES0.59732919
114MKNK20.58526466
115IRAK20.57739054
116NEK20.56804606
117PLK10.56403363
118RET0.55988226
119PAK20.54332991
120SGK10.54158855
121PINK10.53597217
122MST40.52650144
123FYN0.52363135
124TESK20.51571271
125CSNK1D0.51283591
126STK30.50995267
127FGFR10.49978380
128PDPK10.49876364
129PRKAA20.49717469
130SMG10.49336697
131PLK40.49183596
132MKNK10.48948304
133ARAF0.47910945
134DAPK20.46898282
135SGK30.46558194
136LATS20.46353129
137CAMKK10.46341709
138RAF10.46206044
139PIK3CA0.46177307
140PDGFRB0.45303115
141MAPK100.45227082
142CDK10.44742072
143PRKCQ0.44202374
144ADRBK10.44012920
145DYRK20.43853220
146RPS6KA30.43214853
147RPS6KB10.42661214
148ERBB20.42322357
149STK110.41564570
150PRKCI0.41151956
151PRKCH0.40675013
152BRAF0.40113148
153AKT20.40110033
154PRKD10.39822654
155CLK10.37269478
156PRKD20.37224134
157PRKG10.34588581
158ALK0.34544771

Predicted pathways (KEGG)

RankGene SetZ-score
1Steroid biosynthesis_Homo sapiens_hsa001003.73620740
2Nitrogen metabolism_Homo sapiens_hsa009103.63366027
3Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.53463730
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.65352176
5Nicotine addiction_Homo sapiens_hsa050332.49453218
6GABAergic synapse_Homo sapiens_hsa047272.27674321
7Fatty acid elongation_Homo sapiens_hsa000622.26502465
8Glutamatergic synapse_Homo sapiens_hsa047242.22203510
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.12846534
10Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.96788530
11Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.95846270
12Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.91745804
132-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.91115071
14Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.82788509
15Salivary secretion_Homo sapiens_hsa049701.73568410
16Ether lipid metabolism_Homo sapiens_hsa005651.72046075
17Complement and coagulation cascades_Homo sapiens_hsa046101.71436785
18Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.69527780
19Axon guidance_Homo sapiens_hsa043601.66831905
20Gastric acid secretion_Homo sapiens_hsa049711.66061032
21Morphine addiction_Homo sapiens_hsa050321.65204179
22Circadian entrainment_Homo sapiens_hsa047131.64908783
23Pyruvate metabolism_Homo sapiens_hsa006201.64095627
24Synaptic vesicle cycle_Homo sapiens_hsa047211.61620686
25Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.60104969
26Adherens junction_Homo sapiens_hsa045201.58885539
27* Fatty acid biosynthesis_Homo sapiens_hsa000611.46675729
28Long-term potentiation_Homo sapiens_hsa047201.44432226
29Long-term depression_Homo sapiens_hsa047301.43643623
30Biosynthesis of amino acids_Homo sapiens_hsa012301.41000192
31Serotonergic synapse_Homo sapiens_hsa047261.37721278
32Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.35877850
33Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.35130456
34Olfactory transduction_Homo sapiens_hsa047401.33594655
35Butanoate metabolism_Homo sapiens_hsa006501.31880664
36Arginine biosynthesis_Homo sapiens_hsa002201.31506146
37Dopaminergic synapse_Homo sapiens_hsa047281.31359635
38Phototransduction_Homo sapiens_hsa047441.31004390
39Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.30130161
40Dorso-ventral axis formation_Homo sapiens_hsa043201.28461044
41Cocaine addiction_Homo sapiens_hsa050301.27171645
42Amphetamine addiction_Homo sapiens_hsa050311.25670399
43Cholinergic synapse_Homo sapiens_hsa047251.21127340
44Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.17974873
45Insulin secretion_Homo sapiens_hsa049111.17592196
46Carbon metabolism_Homo sapiens_hsa012001.15861761
47Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.14157762
48Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.10215307
49Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.09154080
50Central carbon metabolism in cancer_Homo sapiens_hsa052301.07570156
51* Fatty acid metabolism_Homo sapiens_hsa012121.04969522
52Gap junction_Homo sapiens_hsa045401.04612972
53N-Glycan biosynthesis_Homo sapiens_hsa005101.03909742
54Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.99972420
55Renin secretion_Homo sapiens_hsa049240.99129471
56Sulfur metabolism_Homo sapiens_hsa009200.98336815
57Melanogenesis_Homo sapiens_hsa049160.98089401
58Thyroid cancer_Homo sapiens_hsa052160.96818815
59Phospholipase D signaling pathway_Homo sapiens_hsa040720.93894220
60Tight junction_Homo sapiens_hsa045300.93475835
61Hedgehog signaling pathway_Homo sapiens_hsa043400.93264133
62Phenylalanine metabolism_Homo sapiens_hsa003600.91329052
63Proteoglycans in cancer_Homo sapiens_hsa052050.91062900
64Basal cell carcinoma_Homo sapiens_hsa052170.90920958
65Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.89558825
66GnRH signaling pathway_Homo sapiens_hsa049120.88040685
67Calcium signaling pathway_Homo sapiens_hsa040200.87423532
68Bile secretion_Homo sapiens_hsa049760.87422837
69* PPAR signaling pathway_Homo sapiens_hsa033200.87386286
70cAMP signaling pathway_Homo sapiens_hsa040240.87232915
71mRNA surveillance pathway_Homo sapiens_hsa030150.86522978
72Renal cell carcinoma_Homo sapiens_hsa052110.86216463
73Taste transduction_Homo sapiens_hsa047420.85823110
74ErbB signaling pathway_Homo sapiens_hsa040120.85428100
75Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.85410140
76AMPK signaling pathway_Homo sapiens_hsa041520.85232186
77Sphingolipid metabolism_Homo sapiens_hsa006000.84608635
78Cell cycle_Homo sapiens_hsa041100.84157778
79Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.84056009
80Oxytocin signaling pathway_Homo sapiens_hsa049210.83807282
81Lysine degradation_Homo sapiens_hsa003100.83151140
82Renin-angiotensin system_Homo sapiens_hsa046140.83120678
83Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.83037725
84Aldosterone synthesis and secretion_Homo sapiens_hsa049250.82768663
85Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.82641337
86Fructose and mannose metabolism_Homo sapiens_hsa000510.82537573
87Prion diseases_Homo sapiens_hsa050200.82507694
88Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.82377023
89Pancreatic secretion_Homo sapiens_hsa049720.82193766
90MicroRNAs in cancer_Homo sapiens_hsa052060.81875019
91Thyroid hormone signaling pathway_Homo sapiens_hsa049190.77541478
92Pentose and glucuronate interconversions_Homo sapiens_hsa000400.77211114
93Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.76393757
94Sphingolipid signaling pathway_Homo sapiens_hsa040710.75814399
95Insulin signaling pathway_Homo sapiens_hsa049100.75662221
96Collecting duct acid secretion_Homo sapiens_hsa049660.73347148
97Choline metabolism in cancer_Homo sapiens_hsa052310.73245342
98Small cell lung cancer_Homo sapiens_hsa052220.72877466
99Glycerophospholipid metabolism_Homo sapiens_hsa005640.71552657
100Hippo signaling pathway_Homo sapiens_hsa043900.70932684
101Wnt signaling pathway_Homo sapiens_hsa043100.70748646
102Glucagon signaling pathway_Homo sapiens_hsa049220.69739570
103Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.69562440
104Vitamin B6 metabolism_Homo sapiens_hsa007500.69355620
105Focal adhesion_Homo sapiens_hsa045100.68873199
106Endometrial cancer_Homo sapiens_hsa052130.68586536
107RNA transport_Homo sapiens_hsa030130.68506777
108Mineral absorption_Homo sapiens_hsa049780.68149476
109Vitamin digestion and absorption_Homo sapiens_hsa049770.67783956
110Thyroid hormone synthesis_Homo sapiens_hsa049180.67766897
111Histidine metabolism_Homo sapiens_hsa003400.67584302
112Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.67280745
113Cysteine and methionine metabolism_Homo sapiens_hsa002700.66057261
114Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.65964948
115Estrogen signaling pathway_Homo sapiens_hsa049150.65537785
116TGF-beta signaling pathway_Homo sapiens_hsa043500.64429554
117Ras signaling pathway_Homo sapiens_hsa040140.63536437
118Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.62689742
119Non-homologous end-joining_Homo sapiens_hsa034500.61855153
120Prostate cancer_Homo sapiens_hsa052150.61669600
121Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.61518156
122Vascular smooth muscle contraction_Homo sapiens_hsa042700.60633594
123Ovarian steroidogenesis_Homo sapiens_hsa049130.59557973
124Tyrosine metabolism_Homo sapiens_hsa003500.58234880
125Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.57220995
126Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.56464790
127Cardiac muscle contraction_Homo sapiens_hsa042600.56115657
128Starch and sucrose metabolism_Homo sapiens_hsa005000.55976313
129Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.55385438
130Glioma_Homo sapiens_hsa052140.55137599
131Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.54872945
132Vibrio cholerae infection_Homo sapiens_hsa051100.53363443
133Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.53147846
134* Fatty acid degradation_Homo sapiens_hsa000710.52430137
135alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.51679916
136Phosphatidylinositol signaling system_Homo sapiens_hsa040700.51649741
137cGMP-PKG signaling pathway_Homo sapiens_hsa040220.51119618
138Fat digestion and absorption_Homo sapiens_hsa049750.51114898
139Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.49719348
140Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.49668751
141Circadian rhythm_Homo sapiens_hsa047100.48776151
142Pentose phosphate pathway_Homo sapiens_hsa000300.47559063
143Galactose metabolism_Homo sapiens_hsa000520.46766811
144Alcoholism_Homo sapiens_hsa050340.46023570
145Bladder cancer_Homo sapiens_hsa052190.43872957
146Inositol phosphate metabolism_Homo sapiens_hsa005620.43520578
147Arginine and proline metabolism_Homo sapiens_hsa003300.43423152
148Oocyte meiosis_Homo sapiens_hsa041140.42936377
149Endocytosis_Homo sapiens_hsa041440.42811746
150Rap1 signaling pathway_Homo sapiens_hsa040150.41103722
151Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.39916020
152Protein export_Homo sapiens_hsa030600.39652605
153Propanoate metabolism_Homo sapiens_hsa006400.39462570
154beta-Alanine metabolism_Homo sapiens_hsa004100.39110467
155Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.38788042
156MAPK signaling pathway_Homo sapiens_hsa040100.38512151
157Dilated cardiomyopathy_Homo sapiens_hsa054140.36598172
158ECM-receptor interaction_Homo sapiens_hsa045120.34032476
159Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.33606550

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