ACSL5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in uterus and spleen, and in trace amounts in normal brain, but has markedly increased levels in malignant gliomas. This gene functions in mediating fatty acid-induced glioma cell growth. Three transcript variants encoding two different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1angiotensin maturation (GO:0002003)7.28208269
2triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.35977044
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.98305923
4L-phenylalanine catabolic process (GO:0006559)5.98305923
5regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)5.83601580
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.82101052
7L-phenylalanine metabolic process (GO:0006558)5.82101052
8aromatic amino acid family catabolic process (GO:0009074)5.45163269
9alpha-linolenic acid metabolic process (GO:0036109)5.31352468
10high-density lipoprotein particle remodeling (GO:0034375)5.28929650
11urea metabolic process (GO:0019627)5.24113345
12urea cycle (GO:0000050)5.24113345
13regulation of triglyceride catabolic process (GO:0010896)5.04840700
14phospholipid efflux (GO:0033700)5.03030128
15cysteine metabolic process (GO:0006534)5.01480349
16tryptophan catabolic process (GO:0006569)4.98737077
17indole-containing compound catabolic process (GO:0042436)4.98737077
18indolalkylamine catabolic process (GO:0046218)4.98737077
19kynurenine metabolic process (GO:0070189)4.98295118
20epoxygenase P450 pathway (GO:0019373)4.96197607
21regulation of cholesterol esterification (GO:0010872)4.93339643
22bile acid biosynthetic process (GO:0006699)4.90452442
23nitrogen cycle metabolic process (GO:0071941)4.78213281
24reverse cholesterol transport (GO:0043691)4.77875474
25tryptophan metabolic process (GO:0006568)4.73320084
26negative regulation of fibrinolysis (GO:0051918)4.71807418
27fat-soluble vitamin biosynthetic process (GO:0042362)4.68425254
28peptidyl-glutamic acid carboxylation (GO:0017187)4.67962993
29protein carboxylation (GO:0018214)4.67962993
30lipoprotein transport (GO:0042953)4.67345481
31glyoxylate metabolic process (GO:0046487)4.67016298
32fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.65465596
33negative regulation of cholesterol transport (GO:0032375)4.60567858
34negative regulation of sterol transport (GO:0032372)4.60567858
35intestinal cholesterol absorption (GO:0030299)4.60032228
36sulfur amino acid catabolic process (GO:0000098)4.59638180
37protein-lipid complex remodeling (GO:0034368)4.59421242
38macromolecular complex remodeling (GO:0034367)4.59421242
39plasma lipoprotein particle remodeling (GO:0034369)4.59421242
40NADH metabolic process (GO:0006734)4.53046827
41complement activation, alternative pathway (GO:0006957)4.49691806
42regulation of protein activation cascade (GO:2000257)4.48291277
43antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.48243041
44plasma lipoprotein particle assembly (GO:0034377)4.46530859
45antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.44426217
46regulation of fibrinolysis (GO:0051917)4.44063546
47cholesterol efflux (GO:0033344)4.41274612
48antigen processing and presentation of endogenous antigen (GO:0019883)4.37329395
49lysine metabolic process (GO:0006553)4.36281862
50lysine catabolic process (GO:0006554)4.36281862
51bile acid metabolic process (GO:0008206)4.29672178
52homocysteine metabolic process (GO:0050667)4.27470943
53plasma lipoprotein particle clearance (GO:0034381)4.27126802
54regulation of guanylate cyclase activity (GO:0031282)4.25055842
55positive regulation of lipoprotein lipase activity (GO:0051006)4.20835289
56positive regulation of triglyceride lipase activity (GO:0061365)4.20835289
57regulation of cellular extravasation (GO:0002691)4.20475148
58regulation of complement activation (GO:0030449)4.19992639
59acylglycerol homeostasis (GO:0055090)4.16881665
60triglyceride homeostasis (GO:0070328)4.16881665
61amino-acid betaine metabolic process (GO:0006577)4.11515604
62bile acid and bile salt transport (GO:0015721)4.11187590
63protein-lipid complex assembly (GO:0065005)4.07979291
64hormone catabolic process (GO:0042447)4.03226286
65drug catabolic process (GO:0042737)3.99705218
66serine family amino acid catabolic process (GO:0009071)3.95421535
67aromatic amino acid family metabolic process (GO:0009072)3.94279153
68very-low-density lipoprotein particle assembly (GO:0034379)3.93318895
69intestinal absorption (GO:0050892)3.89733433
70ethanol oxidation (GO:0006069)3.88364743
71cholesterol homeostasis (GO:0042632)3.81927065
72peptide catabolic process (GO:0043171)3.81893425
73positive regulation of lipid catabolic process (GO:0050996)3.81157035
74cellular glucuronidation (GO:0052695)3.78785887
75lipoprotein metabolic process (GO:0042157)3.78182720
76sterol homeostasis (GO:0055092)3.76687621
77tyrosine metabolic process (GO:0006570)3.75544707
78regulation of cholesterol homeostasis (GO:2000188)3.72050225
79plasma lipoprotein particle organization (GO:0071827)3.71942883
80regulation of vitamin metabolic process (GO:0030656)3.71311788
81phospholipid homeostasis (GO:0055091)3.68994485
82glycine metabolic process (GO:0006544)3.68830548
83alpha-amino acid catabolic process (GO:1901606)3.68201801
84flavonoid metabolic process (GO:0009812)3.68127167
85imidazole-containing compound metabolic process (GO:0052803)3.67613318
86diacylglycerol metabolic process (GO:0046339)3.65413626
87cellular ketone body metabolic process (GO:0046950)3.58213351
88glycosphingolipid catabolic process (GO:0046479)3.57060264
89fructose metabolic process (GO:0006000)3.56344228
90serine family amino acid metabolic process (GO:0009069)3.56133689
91glutamate metabolic process (GO:0006536)3.56115331
92protein-lipid complex subunit organization (GO:0071825)3.54370229
93serine family amino acid biosynthetic process (GO:0009070)3.52573016
94benzene-containing compound metabolic process (GO:0042537)3.52453933
95low-density lipoprotein particle remodeling (GO:0034374)3.49991196
96indolalkylamine metabolic process (GO:0006586)3.49165217
97antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.48225098
98response to nitrosative stress (GO:0051409)3.47396088
99positive regulation of fatty acid biosynthetic process (GO:0045723)3.46154082
100cellular modified amino acid catabolic process (GO:0042219)3.45475109
101fibrinolysis (GO:0042730)3.45416884
102glycolipid catabolic process (GO:0019377)3.45264141
103regulation of systemic arterial blood pressure by hormone (GO:0001990)3.45012419
104regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)3.45012419
105endocrine process (GO:0050886)3.45012419
106drug metabolic process (GO:0017144)3.43701061
107aldehyde catabolic process (GO:0046185)3.41308493
108positive regulation of triglyceride metabolic process (GO:0090208)3.40628976
109cellular amino acid catabolic process (GO:0009063)3.38395394
110dicarboxylic acid biosynthetic process (GO:0043650)3.36258354
111uronic acid metabolic process (GO:0006063)3.35318685
112glucuronate metabolic process (GO:0019585)3.35318685
113blood coagulation, intrinsic pathway (GO:0007597)3.35143509
114arginine metabolic process (GO:0006525)3.34074788
115coenzyme catabolic process (GO:0009109)3.31573681
116cellular biogenic amine catabolic process (GO:0042402)3.31510104
117amine catabolic process (GO:0009310)3.31510104
118negative regulation of lipase activity (GO:0060192)3.28531268
119cholesterol transport (GO:0030301)3.26906725
120sterol transport (GO:0015918)3.26906725
121ethanol metabolic process (GO:0006067)3.26750669
122regulation of bile acid biosynthetic process (GO:0070857)3.25470611
123drug transmembrane transport (GO:0006855)3.24558945
124adhesion of symbiont to host cell (GO:0044650)3.19840295
125virion attachment to host cell (GO:0019062)3.19840295
126maintenance of gastrointestinal epithelium (GO:0030277)3.16363671
127positive regulation of guanylate cyclase activity (GO:0031284)3.10545818
128immunoglobulin mediated immune response (GO:0016064)3.03949109
129antimicrobial humoral response (GO:0019730)3.02507144
130regulation of systemic arterial blood pressure (GO:0003073)3.01916592
131antibacterial humoral response (GO:0019731)3.00932043
132complement activation, classical pathway (GO:0006958)2.91975737
133negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.87340923
134negative regulation of cell killing (GO:0031342)2.87340923
135exogenous drug catabolic process (GO:0042738)2.83738285
136adhesion of symbiont to host (GO:0044406)2.83267075
137renal system process involved in regulation of blood volume (GO:0001977)2.82680004
138positive regulation of pseudopodium assembly (GO:0031274)2.80379062
139ceramide catabolic process (GO:0046514)2.80002559
140detection of bacterium (GO:0016045)2.68776018
141alkaloid metabolic process (GO:0009820)2.66790623
142positive regulation of Cdc42 GTPase activity (GO:0043089)2.66256418
143regulation of dendritic cell antigen processing and presentation (GO:0002604)2.66248537
144detection of other organism (GO:0098543)2.64963444
145peptide hormone processing (GO:0016486)2.63965309
146positive regulation of gamma-delta T cell activation (GO:0046645)2.63085582
147leukotriene metabolic process (GO:0006691)2.59661350
148cellular response to reactive nitrogen species (GO:1902170)2.57451459
149receptor guanylyl cyclase signaling pathway (GO:0007168)2.56969391
150interferon-gamma-mediated signaling pathway (GO:0060333)2.55788535
151complement activation (GO:0006956)2.55677352
152thrombin receptor signaling pathway (GO:0070493)2.54033596
153NIK/NF-kappaB signaling (GO:0038061)2.53667000
154regulation of cGMP biosynthetic process (GO:0030826)2.50721140
155regulation of cytokine secretion involved in immune response (GO:0002739)2.49788182
156drug transport (GO:0015893)2.47961466
157citrulline biosynthetic process (GO:0019240)2.47477590
158sphingolipid catabolic process (GO:0030149)2.45031280
159regulation of pseudopodium assembly (GO:0031272)2.44347490
160transcytosis (GO:0045056)2.44001028
161digestive system process (GO:0022600)2.43711176
162glutamine family amino acid biosynthetic process (GO:0009084)2.43356076
163cyclooxygenase pathway (GO:0019371)2.39889643
164oligosaccharide catabolic process (GO:0009313)2.39790089

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.71932280
2* RXR_22158963_ChIP-Seq_LIVER_Mouse6.83121468
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.15104085
4EGR1_23403033_ChIP-Seq_LIVER_Mouse5.65169231
5* LXR_22158963_ChIP-Seq_LIVER_Mouse5.31645250
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.72758273
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.32088964
8BP1_19119308_ChIP-ChIP_Hs578T_Human4.11018404
9FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.99505464
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.35675697
11NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.12848629
12IRF8_22096565_ChIP-ChIP_GC-B_Human2.69277596
13GATA1_22025678_ChIP-Seq_K562_Human2.56766898
14HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.37242261
15FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.25969945
16TP63_17297297_ChIP-ChIP_HaCaT_Human1.99283918
17* IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.95071569
18TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.93581355
19STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.82537073
20TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.80781864
21TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.77486865
22* CLOCK_20551151_ChIP-Seq_293T_Human1.69855790
23VDR_24763502_ChIP-Seq_THP-1_Human1.68118948
24CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.54516950
25STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.49196793
26NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.46048609
27* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.45662306
28RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.44769271
29VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.40182659
30RUNX_20019798_ChIP-Seq_JUKART_Human1.39764569
31* GATA4_25053715_ChIP-Seq_YYC3_Human1.35763668
32* SPI1_23547873_ChIP-Seq_NB4_Human1.35016282
33* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.33253395
34NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.33192357
35THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.33033271
36NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.32621115
37MYB_21317192_ChIP-Seq_ERMYB_Mouse1.32044212
38SPI1_23127762_ChIP-Seq_K562_Human1.30883088
39IRF8_21731497_ChIP-ChIP_J774_Mouse1.29213919
40GATA2_21666600_ChIP-Seq_HMVEC_Human1.28996760
41* FOXA2_19822575_ChIP-Seq_HepG2_Human1.27592923
42VDR_24787735_ChIP-Seq_THP-1_Human1.25205283
43* HNF4A_19822575_ChIP-Seq_HepG2_Human1.23462646
44Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.22181909
45SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.21742079
46BRD4_27068464_Chip-Seq_AML-cells_Mouse1.21376056
47FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.21245088
48SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.20750149
49IRF8_27001747_Chip-Seq_BMDM_Mouse1.18526307
50* IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.15288065
51SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.11399832
52RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.11293041
53BCL6_27268052_Chip-Seq_Bcells_Human1.10921621
54NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.10292573
55CDX2_20551321_ChIP-Seq_CACO-2_Human1.10241513
56TCF7_22412390_ChIP-Seq_EML_Mouse1.09956204
57RARG_19884340_ChIP-ChIP_MEFs_Mouse1.06988514
58SMAD_19615063_ChIP-ChIP_OVARY_Human1.06752433
59PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06532466
60* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.06322294
61GATA6_25053715_ChIP-Seq_YYC3_Human1.05469447
62* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.04098250
63CDX2_19796622_ChIP-Seq_MESCs_Mouse1.02700929
64ZNF263_19887448_ChIP-Seq_K562_Human1.02663285
65* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.02370799
66ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.95950140
67* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.94910056
68P63_26484246_Chip-Seq_KERATINOCYTES_Human0.94062250
69SCL_19346495_ChIP-Seq_HPC-7_Human0.93527448
70GATA2_22383799_ChIP-Seq_G1ME_Mouse0.92673284
71RXRA_24833708_ChIP-Seq_LIVER_Mouse0.91710608
72* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.91353786
73GATA3_27048872_Chip-Seq_THYMUS_Human0.91271366
74MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.91125598
75FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.90473741
76* GATA1_19941827_ChIP-Seq_MEL_Mouse0.90323670
77LXR_22292898_ChIP-Seq_THP-1_Human0.89039035
78GATA1_22383799_ChIP-Seq_G1ME_Mouse0.88245001
79GATA2_19941826_ChIP-Seq_K562_Human0.86297333
80TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.85228742
81ESR1_15608294_ChIP-ChIP_MCF-7_Human0.83037491
82FOXO3_23340844_ChIP-Seq_DLD1_Human0.82272569
83SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.82143250
84HTT_18923047_ChIP-ChIP_STHdh_Human0.81932679
85* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.81518455
86STAT3_1855785_ChIP-Seq_MESCs_Mouse0.80451258
87* MAF_26560356_Chip-Seq_TH1_Human0.80183729
88* SOX2_20726797_ChIP-Seq_SW620_Human0.78377927
89STAT4_19710469_ChIP-ChIP_TH1__Mouse0.77820310
90GATA1_19941826_ChIP-Seq_K562_Human0.76909954
91* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.75159774
92GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.74665288
93STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.74416181
94CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.73799592
95RACK7_27058665_Chip-Seq_MCF-7_Human0.73251709
96ATF3_27146783_Chip-Seq_COLON_Human0.72664911
97* PPAR_26484153_Chip-Seq_NCI-H1993_Human0.72464943
98AR_21909140_ChIP-Seq_LNCAP_Human0.72172549
99VDR_21846776_ChIP-Seq_THP-1_Human0.71601278
100* MYB_26560356_Chip-Seq_TH1_Human0.70527077
101EGR1_19032775_ChIP-ChIP_M12_Human0.70246355
102E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.70104780
103CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.69696516
104RUNX1_22412390_ChIP-Seq_EML_Mouse0.69639692
105RARA_24833708_ChIP-Seq_LIVER_Mouse0.68632015
106MYC_22102868_ChIP-Seq_BL_Human0.68282572
107EGR1_19374776_ChIP-ChIP_THP-1_Human0.68149347
108SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.65860704
109SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.65389999
110ESR2_21235772_ChIP-Seq_MCF-7_Human0.65017761
111* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.64209610
112UTX_26944678_Chip-Seq_JUKART_Human0.64046533
113* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.63866529
114CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.63195775
115BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.63068937
116TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.62899452
117MYB_26560356_Chip-Seq_TH2_Human0.62625092
118BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.62566260
119LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.62209066
120* CEBPB_22108803_ChIP-Seq_LS180_Human0.62108412
121* PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.62006510
122STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.61437925
123ELK3_25401928_ChIP-Seq_HUVEC_Human0.61038354
124BCOR_27268052_Chip-Seq_Bcells_Human0.60501351

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis7.22657527
2MP0002139_abnormal_hepatobiliary_system7.02685317
3MP0005085_abnormal_gallbladder_physiolo5.33219016
4MP0005365_abnormal_bile_salt4.99315169
5MP0008875_abnormal_xenobiotic_pharmacok4.39349266
6MP0009840_abnormal_foam_cell3.57695071
7MP0003252_abnormal_bile_duct3.56337991
8MP0003806_abnormal_nucleotide_metabolis3.43685430
9MP0010329_abnormal_lipoprotein_level3.31693497
10MP0001666_abnormal_nutrient_absorption3.08213025
11MP0005083_abnormal_biliary_tract2.67623395
12MP0003191_abnormal_cellular_cholesterol2.57595616
13MP0005332_abnormal_amino_acid2.18608568
14MP0000609_abnormal_liver_physiology2.08579332
15MP0003866_abnormal_defecation2.03264327
16MP0002138_abnormal_hepatobiliary_system1.99581454
17MP0003195_calcinosis1.91498738
18MP0004019_abnormal_vitamin_homeostasis1.87044151
19MP0002118_abnormal_lipid_homeostasis1.82829895
20MP0002148_abnormal_hypersensitivity_rea1.70024149
21MP0005319_abnormal_enzyme/_coenzyme1.67595167
22MP0003656_abnormal_erythrocyte_physiolo1.65750479
23MP0005671_abnormal_response_to1.65715206
24MP0009379_abnormal_foot_pigmentation1.58549986
25MP0005000_abnormal_immune_tolerance1.56058246
26MP0003705_abnormal_hypodermis_morpholog1.55598198
27MP0000490_abnormal_crypts_of1.46898077
28MP0003868_abnormal_feces_composition1.45694472
29MP0010234_abnormal_vibrissa_follicle1.43549356
30MP0005584_abnormal_enzyme/coenzyme_acti1.42993766
31MP0009697_abnormal_copulation1.38505237
32MP0001764_abnormal_homeostasis1.37308304
33MP0009333_abnormal_splenocyte_physiolog1.36009991
34MP0003436_decreased_susceptibility_to1.32496445
35MP0009643_abnormal_urine_homeostasis1.32456541
36MP0000465_gastrointestinal_hemorrhage1.31806070
37MP0001664_abnormal_digestion1.31278011
38MP0003300_gastrointestinal_ulcer1.27368186
39MP0005409_darkened_coat_color1.27051197
40MP0002254_reproductive_system_inflammat1.26395297
41MP0009764_decreased_sensitivity_to1.23787960
42MP0003763_abnormal_thymus_physiology1.23615982
43MP0003186_abnormal_redox_activity1.23335905
44MP0005670_abnormal_white_adipose1.23193565
45MP0001819_abnormal_immune_cell1.22820219
46MP0002420_abnormal_adaptive_immunity1.22109932
47MP0005451_abnormal_body_composition1.19340306
48MP0001663_abnormal_digestive_system1.18833168
49MP0005464_abnormal_platelet_physiology1.18276413
50MP0002006_tumorigenesis1.17687430
51MP0008469_abnormal_protein_level1.17644731
52MP0000598_abnormal_liver_morphology1.17596552
53MP0003724_increased_susceptibility_to1.16785749
54MP0000477_abnormal_intestine_morphology1.14661583
55MP0000604_amyloidosis1.13884242
56MP0008004_abnormal_stomach_pH1.12793466
57MP0001765_abnormal_ion_homeostasis1.07067786
58MP0004947_skin_inflammation1.04464306
59MP0009763_increased_sensitivity_to1.02712523
60MP0005636_abnormal_mineral_homeostasis0.99117486
61MP0005310_abnormal_salivary_gland0.97781426
62MP0004782_abnormal_surfactant_physiolog0.96654798
63MP0001835_abnormal_antigen_presentation0.95845661
64MP0002998_abnormal_bone_remodeling0.95305813
65MP0009785_altered_susceptibility_to0.95227841
66MP0000858_altered_metastatic_potential0.93864075
67MP0000716_abnormal_immune_system0.92237014
68MP0002796_impaired_skin_barrier0.90300333
69MP0002396_abnormal_hematopoietic_system0.88364391
70MP0008260_abnormal_autophagy0.86566685
71MP0010155_abnormal_intestine_physiology0.86559019
72MP0009115_abnormal_fat_cell0.85993726
73MP0009642_abnormal_blood_homeostasis0.85911598
74MP0005084_abnormal_gallbladder_morpholo0.85145529
75MP0005381_digestive/alimentary_phenotyp0.85105762
76MP0010368_abnormal_lymphatic_system0.84973145
77MP0003011_delayed_dark_adaptation0.83927583
78MP0002405_respiratory_system_inflammati0.83680728
79MP0005025_abnormal_response_to0.83267994
80MP0002876_abnormal_thyroid_physiology0.83170179
81MP0005666_abnormal_adipose_tissue0.82490411
82MP0001845_abnormal_inflammatory_respons0.82357517
83MP0000685_abnormal_immune_system0.81775173
84MP0009765_abnormal_xenobiotic_induced0.81400122
85MP0005535_abnormal_body_temperature0.80230539
86MP0003448_altered_tumor_morphology0.79316101
87MP0004264_abnormal_extraembryonic_tissu0.78425621
88MP0002398_abnormal_bone_marrow0.76649211
89MP0005408_hypopigmentation0.76543722
90MP0004147_increased_porphyrin_level0.76181825
91MP0001853_heart_inflammation0.75654491
92MP0000678_abnormal_parathyroid_gland0.74093148
93MP0002419_abnormal_innate_immunity0.73740834
94MP0002166_altered_tumor_susceptibility0.73456970
95MP0006054_spinal_hemorrhage0.73390501
96MP0002429_abnormal_blood_cell0.73022173
97MP0005165_increased_susceptibility_to0.72955075
98MP0001873_stomach_inflammation0.72726593
99MP0004858_abnormal_nervous_system0.72651289
100MP0006082_CNS_inflammation0.72417524
101MP0005647_abnormal_sex_gland0.72335829
102MP0005376_homeostasis/metabolism_phenot0.70190784
103MP0002136_abnormal_kidney_physiology0.69597251
104MP0006036_abnormal_mitochondrial_physio0.66528765
105MP0001800_abnormal_humoral_immune0.65445344
106MP0005058_abnormal_lysosome_morphology0.65017847
107MP0005166_decreased_susceptibility_to0.63255005
108MP0002078_abnormal_glucose_homeostasis0.62157461
109MP0002971_abnormal_brown_adipose0.62012002
110MP0003183_abnormal_peptide_metabolism0.61997850
111MP0005334_abnormal_fat_pad0.61668769
112MP0003303_peritoneal_inflammation0.61535659
113MP0005448_abnormal_energy_balance0.61233741
114MP0005220_abnormal_exocrine_pancreas0.60602988
115MP0010352_gastrointestinal_tract_polyps0.60285210
116MP0008873_increased_physiological_sensi0.60168765
117MP0003453_abnormal_keratinocyte_physiol0.59924228
118MP0001756_abnormal_urination0.57875476
119MP0001533_abnormal_skeleton_physiology0.57710027
120MP0003075_altered_response_to0.57150467
121MP0005387_immune_system_phenotype0.56431608
122MP0001790_abnormal_immune_system0.56431608
123MP0003638_abnormal_response/metabolism_0.56003391
124MP0005023_abnormal_wound_healing0.55333706
125MP0001545_abnormal_hematopoietic_system0.54213946
126MP0005397_hematopoietic_system_phenotyp0.54213946
127MP0000249_abnormal_blood_vessel0.53058329
128MP0001243_abnormal_dermal_layer0.52987788
129MP0002060_abnormal_skin_morphology0.52294209
130MP0002723_abnormal_immune_serum0.52219080
131MP0005266_abnormal_metabolism0.52121907
132MP0002132_abnormal_respiratory_system0.51528761
133MP0004130_abnormal_muscle_cell0.50501294
134MP0005501_abnormal_skin_physiology0.49956100
135MP0001881_abnormal_mammary_gland0.49927376
136MP0002452_abnormal_antigen_presenting0.49755279
137MP0005167_abnormal_blood-brain_barrier0.49251526

Predicted human phenotypes

RankGene SetZ-score
1Hypobetalipoproteinemia (HP:0003563)6.36534622
2Intrahepatic cholestasis (HP:0001406)6.19229756
3Deep venous thrombosis (HP:0002625)6.15231366
4Abnormality of monocarboxylic acid metabolism (HP:0010996)5.85756481
5Abnormality of aromatic amino acid family metabolism (HP:0004338)5.81464142
6Xanthomatosis (HP:0000991)5.61012780
7Prolonged partial thromboplastin time (HP:0003645)5.23424869
8Hypolipoproteinemia (HP:0010981)4.49308750
9Abnormality of glutamine family amino acid metabolism (HP:0010902)4.41101009
10Hyperlipoproteinemia (HP:0010980)4.37298492
11Chronic diarrhea (HP:0002028)4.35672714
12Complement deficiency (HP:0004431)4.32962958
13Joint hemorrhage (HP:0005261)4.11293249
14Abnormality of the common coagulation pathway (HP:0010990)4.10362954
15Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.06375710
16Eczematoid dermatitis (HP:0000976)3.99191141
17Hyperammonemia (HP:0001987)3.98521844
18Fat malabsorption (HP:0002630)3.96226869
19Epidermoid cyst (HP:0200040)3.94740090
20Acanthocytosis (HP:0001927)3.72598597
21Abnormality of sulfur amino acid metabolism (HP:0004339)3.68980127
22Conjugated hyperbilirubinemia (HP:0002908)3.64728942
23Abnormality of aspartate family amino acid metabolism (HP:0010899)3.57655613
24Hypoglycemic coma (HP:0001325)3.50278781
25Hypercholesterolemia (HP:0003124)3.48318268
26Hypoalphalipoproteinemia (HP:0003233)3.47476301
27Ketosis (HP:0001946)3.46071128
28Abnormality of the intrinsic pathway (HP:0010989)3.37795729
29Abnormality of complement system (HP:0005339)3.33217201
30Hyperbilirubinemia (HP:0002904)3.31511564
31Abnormality of pyrimidine metabolism (HP:0004353)3.31490787
32Hyperglycinuria (HP:0003108)3.26969646
33Abnormality of methionine metabolism (HP:0010901)3.20898439
34Abnormality of serine family amino acid metabolism (HP:0010894)3.15044196
35Abnormality of glycine metabolism (HP:0010895)3.15044196
36Hyperglycinemia (HP:0002154)3.10993884
37Widely patent fontanelles and sutures (HP:0004492)3.09320123
38Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.06974882
39Abnormality of fatty-acid metabolism (HP:0004359)2.99926004
40Abnormality of nucleobase metabolism (HP:0010932)2.96177232
41Myocardial infarction (HP:0001658)2.87691077
42Abnormality of the vitamin B12 metabolism (HP:0004341)2.87243153
43Hepatocellular carcinoma (HP:0001402)2.84047660
44Pigmentary retinal degeneration (HP:0001146)2.79763310
45Abnormality of macrophages (HP:0004311)2.79406556
46Abnormality of purine metabolism (HP:0004352)2.78520455
47Poikilocytosis (HP:0004447)2.76241778
48Systemic lupus erythematosus (HP:0002725)2.75447890
49Hyperactive renin-angiotensin system (HP:0000841)2.67524877
50Steatorrhea (HP:0002570)2.65367131
51Metabolic acidosis (HP:0001942)2.64341641
52Recurrent gram-negative bacterial infections (HP:0005420)2.63493383
53Malnutrition (HP:0004395)2.62805791
54Abnormality of vitamin B metabolism (HP:0004340)2.61698898
55Ketoacidosis (HP:0001993)2.56249644
56Spastic diplegia (HP:0001264)2.55739500
57Recurrent abscess formation (HP:0002722)2.54915456
58Myositis (HP:0100614)2.54199593
59Gingivitis (HP:0000230)2.53304926
60Orchitis (HP:0100796)2.53183022
61Esophageal varix (HP:0002040)2.53151813
62Flat acetabular roof (HP:0003180)2.46784297
63Vasculitis (HP:0002633)2.46170213
64Abnormal gallbladder physiology (HP:0012438)2.45703940
65Cholecystitis (HP:0001082)2.45703940
66Gingival bleeding (HP:0000225)2.44119873
67Delayed CNS myelination (HP:0002188)2.42730096
68Abnormality of proline metabolism (HP:0010907)2.41973645
69Hydroxyprolinuria (HP:0003080)2.41973645
70Elevated erythrocyte sedimentation rate (HP:0003565)2.41045030
71Abdominal distention (HP:0003270)2.38250295
72Vascular calcification (HP:0004934)2.36543326
73Skin nodule (HP:0200036)2.36453813
74Thin bony cortex (HP:0002753)2.36404629
75Spontaneous abortion (HP:0005268)2.35726794
76Metabolic alkalosis (HP:0200114)2.35119977
77Amyloidosis (HP:0011034)2.35085263
78Alkalosis (HP:0001948)2.34795083
79Abnormality of vitamin metabolism (HP:0100508)2.34534814
80Polycythemia (HP:0001901)2.34118236
81Recurrent bacterial skin infections (HP:0005406)2.33704078
82Abnormality of transition element cation homeostasis (HP:0011030)2.33442540
83Abnormal gallbladder morphology (HP:0012437)2.32776834
84Colitis (HP:0002583)2.32562976
85Cholelithiasis (HP:0001081)2.32247183
86Abnormality of iron homeostasis (HP:0011031)2.31754368
87Glomerulonephritis (HP:0000099)2.29890432
88Increased mean platelet volume (HP:0011877)2.28128958
89Confusion (HP:0001289)2.27798729
90Abnormality of serum amino acid levels (HP:0003112)2.26594236
91Gastrointestinal infarctions (HP:0005244)2.26381908
92Abnormality of small intestinal villus morphology (HP:0011472)2.25625181
93Villous atrophy (HP:0011473)2.25625181
94Hypophosphatemia (HP:0002148)2.25418345
95Decreased circulating renin level (HP:0003351)2.25083375
96Reticulocytosis (HP:0001923)2.24044592
97Autoimmune thrombocytopenia (HP:0001973)2.23803405
98Menorrhagia (HP:0000132)2.23297853
99Petechiae (HP:0000967)2.20300447
100Inflammation of the large intestine (HP:0002037)2.19721675
101Abnormality of dicarboxylic acid metabolism (HP:0010995)2.19673584
102Dicarboxylic aciduria (HP:0003215)2.19673584
103Vacuolated lymphocytes (HP:0001922)2.19591565
104Pustule (HP:0200039)2.18993765
105Thrombophlebitis (HP:0004418)2.18741145
106Wide cranial sutures (HP:0010537)2.17193304
107Abnormal platelet volume (HP:0011876)2.16559954
108Meningitis (HP:0001287)2.15909306
109Encephalitis (HP:0002383)2.14816960
110Gastrointestinal inflammation (HP:0004386)2.13924525
111Hypochromic microcytic anemia (HP:0004840)2.12846520
112Gout (HP:0001997)2.11520398
113Pancreatitis (HP:0001733)2.10450575
114Cardiovascular calcification (HP:0011915)2.10306170
115Mitral stenosis (HP:0001718)2.09286331
116Sensorimotor neuropathy (HP:0007141)2.08513333
117Increased serum ferritin (HP:0003281)2.07484395
118Hypoglycemic seizures (HP:0002173)2.07235460
119Late onset (HP:0003584)2.06826078
120Ileus (HP:0002595)2.06571375
121Focal segmental glomerulosclerosis (HP:0000097)2.05300535
122Pulmonary infiltrates (HP:0002113)2.05172492
123Optic neuritis (HP:0100653)2.02848644
124Retrobulbar optic neuritis (HP:0100654)2.02848644
125Gastrointestinal stroma tumor (HP:0100723)2.01477839
126Joint swelling (HP:0001386)2.01307173
127Generalized aminoaciduria (HP:0002909)2.00784308
128Purpura (HP:0000979)2.00258454
129Lethargy (HP:0001254)2.00006456
130Obstructive lung disease (HP:0006536)1.98728973
131Chronic obstructive pulmonary disease (HP:0006510)1.98728973
132Abnormal platelet function (HP:0011869)1.98392953
133Impaired platelet aggregation (HP:0003540)1.98392953
134Abnormal cartilage morphology (HP:0002763)1.98089093
135Autoimmune hemolytic anemia (HP:0001890)1.97370738
136Mediastinal lymphadenopathy (HP:0100721)1.97233583
137Skin rash (HP:0000988)1.96453457
138Hemorrhage of the eye (HP:0011885)1.94643326
139Neonatal onset (HP:0003623)1.94089047
140Nephrolithiasis (HP:0000787)1.93876835
141Epistaxis (HP:0000421)1.91721121
142Nausea (HP:0002018)1.91023779
143Nephritis (HP:0000123)1.90152053
144Facial shape deformation (HP:0011334)1.89212435
145Potter facies (HP:0002009)1.89212435
146Irritability (HP:0000737)1.88527730
147Recurrent fungal infections (HP:0002841)1.88378988
148Abnormality of the gallbladder (HP:0005264)1.88329722
149Hypotension (HP:0002615)1.86681422
150Abnormal glucose tolerance (HP:0001952)1.85793722
151Glycosuria (HP:0003076)1.85661764
152Abnormality of urine glucose concentration (HP:0011016)1.85661764
153Abnormal delayed hypersensitivity skin test (HP:0002963)1.84313083
154Abnormality of renin-angiotensin system (HP:0000847)1.83313352
155Segmental peripheral demyelination/remyelination (HP:0003481)1.83309715
156Abnormal enzyme/coenzyme activity (HP:0012379)1.83185026
157Hypertriglyceridemia (HP:0002155)1.82985824
158Recurrent viral infections (HP:0004429)1.82637970
159Urticaria (HP:0001025)1.81586849
160Dysostosis multiplex (HP:0000943)1.81530044
161Brushfield spots (HP:0001088)1.81372736
162Hemoptysis (HP:0002105)1.80418233
163Increased purine levels (HP:0004368)1.79825855
164Hyperuricemia (HP:0002149)1.79825855
165Agammaglobulinemia (HP:0004432)1.79798417
166Enlarged epiphyses (HP:0010580)1.79483541

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN14.18219608
2BCKDK3.72558618
3FGFR43.20207705
4PKN22.83711560
5MST1R2.80764348
6SIK12.69238952
7TAOK32.60112132
8TRIB32.59442220
9RIPK42.55205748
10FRK2.47747127
11TYK22.41053925
12MAP4K12.36148461
13TBK12.14131314
14PRPF4B2.10655040
15FLT32.07313542
16PTK61.96990618
17GRK61.96854541
18MAP3K101.95638549
19KDR1.75331806
20STK101.61139973
21MAP3K141.59950265
22MAP2K31.57461695
23LRRK21.54373179
24ZAP701.49079362
25MAPK111.44850482
26NEK91.39686290
27RIPK11.38337999
28JAK31.37529838
29JAK11.36913778
30MAP3K31.32211285
31BLK1.30108447
32JAK21.29971498
33EEF2K1.29384307
34TGFBR21.27931828
35TAOK11.24481461
36STK391.23400678
37MAP3K111.23237510
38SCYL21.22760774
39IKBKE1.21962463
40BMPR21.20935702
41PIK3CA1.18092219
42MST41.17031828
43PIK3CG1.16789670
44ERBB41.14071590
45KIT1.12967755
46CDC42BPA1.09281766
47CDK61.09062152
48PDK21.06257200
49MAP3K121.05478691
50DDR21.05131207
51NME21.03911239
52INSRR1.01728369
53CSK1.00927124
54MAP3K71.00350519
55EPHB11.00034488
56CSF1R0.98628322
57PRKG20.95334413
58PDPK10.92233561
59IRAK30.91822382
60BTK0.91112071
61FGR0.90609200
62NLK0.88549595
63ABL20.87256766
64FGFR30.86313662
65RPS6KA40.80511435
66ITK0.79854606
67PDK10.79790779
68TAOK20.79502635
69PRKAA20.78008641
70OXSR10.76903457
71STK240.76727843
72MAPK40.73612202
73LATS10.72838459
74PIM20.72669310
75SMG10.72379118
76TESK10.72350066
77CDK40.70560127
78MAP2K20.69975959
79MAP2K40.68947363
80MAP3K80.68592979
81MAP2K60.65988961
82EPHA20.65265904
83IRAK10.64731173
84FES0.64704329
85MAP3K20.64388530
86TEC0.63766644
87SYK0.63436775
88LMTK20.63141423
89CAMK1D0.60133355
90IKBKB0.59353383
91HCK0.57936839
92MAP3K130.56141379
93MET0.55346368
94DAPK20.55076029
95PRKCQ0.54972280
96TIE10.54191312
97TGFBR10.53719604
98NUAK10.53446441
99PAK40.52057715
100PDGFRA0.51010675
101PTK20.50083092
102DYRK1B0.49801624
103MAP3K10.49530619
104MAP3K50.49275864
105ERBB20.49208753
106FYN0.47807022
107MAPKAPK30.46988815
108LYN0.46831895
109RET0.46578960
110CHUK0.46345153
111ACVR1B0.46287547
112ICK0.45870398
113MATK0.45807487
114PIM10.45280479
115EIF2AK10.44291405
116IRAK40.43887233
117EGFR0.43646273
118MELK0.42477604
119BMX0.42364728
120STK30.41757290
121LCK0.41102327
122MAP2K10.40405992
123GSK3A0.40209392
124TESK20.39746265
125EPHA30.39357409
126YES10.38689078
127TXK0.38458971
128PRKACG0.38441651
129FER0.37062069
130MAPKAPK20.36155191
131EPHB20.35157432
132IGF1R0.34614211

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.06584662
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.49159843
3Nitrogen metabolism_Homo sapiens_hsa009103.33510314
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.95543121
5Arginine biosynthesis_Homo sapiens_hsa002202.86896694
6Tryptophan metabolism_Homo sapiens_hsa003802.59909167
7Complement and coagulation cascades_Homo sapiens_hsa046102.51389604
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.42913945
9Pentose and glucuronate interconversions_Homo sapiens_hsa000402.39577601
10Caffeine metabolism_Homo sapiens_hsa002322.38018299
11* Fatty acid degradation_Homo sapiens_hsa000712.36188878
12Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.34724722
13Asthma_Homo sapiens_hsa053102.11986222
14Allograft rejection_Homo sapiens_hsa053302.09781948
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.09385170
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.07911532
17Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.06590999
18Fat digestion and absorption_Homo sapiens_hsa049752.06353037
19Histidine metabolism_Homo sapiens_hsa003401.98959728
20Graft-versus-host disease_Homo sapiens_hsa053321.98199048
21Chemical carcinogenesis_Homo sapiens_hsa052041.88217613
22* Peroxisome_Homo sapiens_hsa041461.87851839
23Autoimmune thyroid disease_Homo sapiens_hsa053201.87753198
24Staphylococcus aureus infection_Homo sapiens_hsa051501.87493264
25Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.86073356
26* PPAR signaling pathway_Homo sapiens_hsa033201.84525651
27Drug metabolism - other enzymes_Homo sapiens_hsa009831.84102523
28Selenocompound metabolism_Homo sapiens_hsa004501.67818256
29Propanoate metabolism_Homo sapiens_hsa006401.66823578
30Butanoate metabolism_Homo sapiens_hsa006501.64691913
31beta-Alanine metabolism_Homo sapiens_hsa004101.62605172
32Steroid hormone biosynthesis_Homo sapiens_hsa001401.61539944
33Starch and sucrose metabolism_Homo sapiens_hsa005001.61156789
34Bile secretion_Homo sapiens_hsa049761.60960972
35Retinol metabolism_Homo sapiens_hsa008301.60790037
36Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.58433585
37* Fatty acid metabolism_Homo sapiens_hsa012121.55549788
38Folate biosynthesis_Homo sapiens_hsa007901.52591628
392-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.50125133
40Type I diabetes mellitus_Homo sapiens_hsa049401.47042148
41Vitamin digestion and absorption_Homo sapiens_hsa049771.46388576
42Other glycan degradation_Homo sapiens_hsa005111.44387628
43ABC transporters_Homo sapiens_hsa020101.41847595
44Sulfur metabolism_Homo sapiens_hsa009201.40022965
45Phenylalanine metabolism_Homo sapiens_hsa003601.35312955
46Pyruvate metabolism_Homo sapiens_hsa006201.34748578
47Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.34238453
48Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.29550485
49Cyanoamino acid metabolism_Homo sapiens_hsa004601.27348546
50Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.22086942
51Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.21692925
52Carbon metabolism_Homo sapiens_hsa012001.21200546
53Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.18775528
54Cysteine and methionine metabolism_Homo sapiens_hsa002701.17654161
55Biosynthesis of amino acids_Homo sapiens_hsa012301.17466733
56Arachidonic acid metabolism_Homo sapiens_hsa005901.17264000
57Tyrosine metabolism_Homo sapiens_hsa003501.16289343
58Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.15900891
59Fatty acid elongation_Homo sapiens_hsa000621.11002757
60Maturity onset diabetes of the young_Homo sapiens_hsa049501.07783222
61Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.03323074
62Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.01765526
63Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.98763804
64Sulfur relay system_Homo sapiens_hsa041220.96718422
65Steroid biosynthesis_Homo sapiens_hsa001000.92012251
66Pentose phosphate pathway_Homo sapiens_hsa000300.91248320
67Glutathione metabolism_Homo sapiens_hsa004800.90231032
68Viral myocarditis_Homo sapiens_hsa054160.89956659
69Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.87208796
70Arginine and proline metabolism_Homo sapiens_hsa003300.83942241
71One carbon pool by folate_Homo sapiens_hsa006700.83136394
72Tuberculosis_Homo sapiens_hsa051520.81542877
73Glycerolipid metabolism_Homo sapiens_hsa005610.77669281
74Influenza A_Homo sapiens_hsa051640.75617081
75Renin-angiotensin system_Homo sapiens_hsa046140.74756622
76Galactose metabolism_Homo sapiens_hsa000520.73548837
77Osteoclast differentiation_Homo sapiens_hsa043800.71779605
78Lysine degradation_Homo sapiens_hsa003100.70559173
79Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.68456847
80Rheumatoid arthritis_Homo sapiens_hsa053230.68038802
81Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.64336210
82TNF signaling pathway_Homo sapiens_hsa046680.64163433
83Sphingolipid metabolism_Homo sapiens_hsa006000.59501923
84Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.56103899
85Herpes simplex infection_Homo sapiens_hsa051680.55857178
86Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.54667162
87B cell receptor signaling pathway_Homo sapiens_hsa046620.51392571
88Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.50134543
89Ether lipid metabolism_Homo sapiens_hsa005650.49745970
90NOD-like receptor signaling pathway_Homo sapiens_hsa046210.47376890
91Leukocyte transendothelial migration_Homo sapiens_hsa046700.45612190
92Fructose and mannose metabolism_Homo sapiens_hsa000510.45150344
93Salmonella infection_Homo sapiens_hsa051320.42095682
94Lysosome_Homo sapiens_hsa041420.39861672
95Pancreatic secretion_Homo sapiens_hsa049720.38983347
96Chemokine signaling pathway_Homo sapiens_hsa040620.38884321
97* Metabolic pathways_Homo sapiens_hsa011000.38471502
98Mineral absorption_Homo sapiens_hsa049780.36317983
99Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.36314162
100Vitamin B6 metabolism_Homo sapiens_hsa007500.34442252
101Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.33324419
102Measles_Homo sapiens_hsa051620.32442534
103Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.31889197
104Phagosome_Homo sapiens_hsa041450.31368723
105Insulin resistance_Homo sapiens_hsa049310.29497233
106Carbohydrate digestion and absorption_Homo sapiens_hsa049730.28049672
107Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.27794764
108Jak-STAT signaling pathway_Homo sapiens_hsa046300.25242790
109* Adipocytokine signaling pathway_Homo sapiens_hsa049200.20651061
110alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.20566974
111Legionellosis_Homo sapiens_hsa051340.18422173
112Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.16370527
113Pertussis_Homo sapiens_hsa051330.15815353
114RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.12811893
115Glycerophospholipid metabolism_Homo sapiens_hsa005640.10511258
116Linoleic acid metabolism_Homo sapiens_hsa005910.08268691
117Hepatitis C_Homo sapiens_hsa051600.08184243
118Leishmaniasis_Homo sapiens_hsa051400.07722664
119Prion diseases_Homo sapiens_hsa050200.07612141
120Intestinal immune network for IgA production_Homo sapiens_hsa046720.06398201
121Toll-like receptor signaling pathway_Homo sapiens_hsa046200.00810156
122Bladder cancer_Homo sapiens_hsa05219-0.0745178
123Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.0736858
124Toxoplasmosis_Homo sapiens_hsa05145-0.0633447
125* Fatty acid biosynthesis_Homo sapiens_hsa00061-0.0624673
126Hematopoietic cell lineage_Homo sapiens_hsa04640-0.0568021
127Systemic lupus erythematosus_Homo sapiens_hsa05322-0.0501444
128AMPK signaling pathway_Homo sapiens_hsa04152-0.0472723
129Antigen processing and presentation_Homo sapiens_hsa04612-0.0382367
130Protein digestion and absorption_Homo sapiens_hsa04974-0.0344472
131Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.0283312
132NF-kappa B signaling pathway_Homo sapiens_hsa04064-0.0236305
133African trypanosomiasis_Homo sapiens_hsa05143-0.0089057
134Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0027843
135Primary immunodeficiency_Homo sapiens_hsa05340-0.0010830

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