ACSL6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene catalyzes the formation of acyl-CoA from fatty acids, ATP, and CoA, using magnesium as a cofactor. The encoded protein plays a major role in fatty acid metabolism in the brain. Translocations with the ETV6 gene are causes of myelodysplastic syndrome with basophilia, acute myelogenous leukemia with eosinophilia, and acute eosinophilic leukemia. Several transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.49952763
2cellular potassium ion homeostasis (GO:0030007)5.28504582
3locomotory exploration behavior (GO:0035641)5.26531751
4synaptic vesicle maturation (GO:0016188)5.20258547
5sodium ion export (GO:0071436)4.98222891
6synaptic vesicle exocytosis (GO:0016079)4.84535257
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.76510975
8positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.75944175
9glutamate secretion (GO:0014047)4.65280390
10vocalization behavior (GO:0071625)4.60510271
11gamma-aminobutyric acid transport (GO:0015812)4.57649132
12neuronal action potential propagation (GO:0019227)4.47188121
13L-amino acid import (GO:0043092)4.43739648
14membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.41483021
15regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.39316166
16axon ensheathment in central nervous system (GO:0032291)4.37934056
17central nervous system myelination (GO:0022010)4.37934056
18neurotransmitter-gated ion channel clustering (GO:0072578)4.35660139
19ionotropic glutamate receptor signaling pathway (GO:0035235)4.33696787
20regulation of synaptic vesicle exocytosis (GO:2000300)4.30381706
21cell communication by electrical coupling (GO:0010644)4.18150439
22neurotransmitter secretion (GO:0007269)4.18118241
23regulation of glutamate receptor signaling pathway (GO:1900449)4.12156082
24glutamate receptor signaling pathway (GO:0007215)4.11865946
25neuron cell-cell adhesion (GO:0007158)4.07619859
26synaptic vesicle docking involved in exocytosis (GO:0016081)4.07511490
27cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.07208073
28presynaptic membrane assembly (GO:0097105)4.06037313
29protein localization to synapse (GO:0035418)4.00863185
30synaptic transmission, glutamatergic (GO:0035249)3.96379996
31regulation of synapse structural plasticity (GO:0051823)3.92309513
32presynaptic membrane organization (GO:0097090)3.91762418
33regulation of neuronal synaptic plasticity (GO:0048168)3.91090431
34alanine transport (GO:0032328)3.90122607
35positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.88664574
36regulation of synaptic vesicle transport (GO:1902803)3.86110062
37amino acid import (GO:0043090)3.86042316
38G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.84848763
39regulation of long-term neuronal synaptic plasticity (GO:0048169)3.83211544
40potassium ion import (GO:0010107)3.82945388
41exploration behavior (GO:0035640)3.82863198
42response to auditory stimulus (GO:0010996)3.82625854
43layer formation in cerebral cortex (GO:0021819)3.81500939
44proline transport (GO:0015824)3.75910026
45potassium ion homeostasis (GO:0055075)3.71963177
46C4-dicarboxylate transport (GO:0015740)3.68685005
47serotonin metabolic process (GO:0042428)3.68297431
48cellular sodium ion homeostasis (GO:0006883)3.67169322
49neuron-neuron synaptic transmission (GO:0007270)3.65603225
50long-term memory (GO:0007616)3.64944868
51neurotransmitter transport (GO:0006836)3.56786735
52negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.55871666
53regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.55173922
54transmission of nerve impulse (GO:0019226)3.53488865
55auditory behavior (GO:0031223)3.50504905
56regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.48015025
57primary amino compound metabolic process (GO:1901160)3.44993893
58negative regulation of synaptic transmission, GABAergic (GO:0032229)3.44174871
59startle response (GO:0001964)3.39109401
60positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.38810017
61regulation of synaptic transmission, glutamatergic (GO:0051966)3.33895484
62regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.32462775
63cerebellar Purkinje cell differentiation (GO:0021702)3.31847471
64regulation of neurotransmitter levels (GO:0001505)3.30431348
65neuromuscular synaptic transmission (GO:0007274)3.28685358
66negative regulation of cytosolic calcium ion concentration (GO:0051481)3.26491617
67positive regulation of potassium ion transmembrane transport (GO:1901381)3.26029098
68membrane depolarization during action potential (GO:0086010)3.22954854
69glycine transport (GO:0015816)3.22521584
70gamma-aminobutyric acid signaling pathway (GO:0007214)3.22501198
71neuromuscular process controlling posture (GO:0050884)3.21509030
72activation of protein kinase A activity (GO:0034199)3.21400028
73synaptic transmission (GO:0007268)3.21120377
74regulation of synapse maturation (GO:0090128)3.20997340
75regulation of synaptic plasticity (GO:0048167)3.18474907
76regulation of excitatory postsynaptic membrane potential (GO:0060079)3.18438699
77dendrite morphogenesis (GO:0048813)3.18125001
78long-term synaptic potentiation (GO:0060291)3.18070854
79dendritic spine morphogenesis (GO:0060997)3.17759483
80positive regulation of dendritic spine development (GO:0060999)3.17540767
81regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.17130542
82behavioral response to nicotine (GO:0035095)3.16721808
83synaptic vesicle endocytosis (GO:0048488)3.15146931
84response to pheromone (GO:0019236)3.14571129
85prepulse inhibition (GO:0060134)3.13959172
86regulation of neurotransmitter uptake (GO:0051580)3.13921891
87positive regulation of membrane potential (GO:0045838)3.13444411
88negative regulation of astrocyte differentiation (GO:0048712)3.12866700
89response to histamine (GO:0034776)3.12624140
90neuromuscular process controlling balance (GO:0050885)3.12585155
91adult walking behavior (GO:0007628)3.10975901
92regulation of neurotransmitter secretion (GO:0046928)3.10775372
93cerebellar granule cell differentiation (GO:0021707)3.09410298
94regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.08457496
95positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.08250422
96cell differentiation in hindbrain (GO:0021533)3.06677956
97regulation of postsynaptic membrane potential (GO:0060078)3.06052432
98acidic amino acid transport (GO:0015800)3.05678672
99neurotransmitter uptake (GO:0001504)3.04601864
100membrane hyperpolarization (GO:0060081)3.02947252
101positive regulation of neurotransmitter transport (GO:0051590)3.02706311
102neuron recognition (GO:0008038)3.01262231
103cellular potassium ion transport (GO:0071804)2.99645006
104potassium ion transmembrane transport (GO:0071805)2.99645006
105detection of calcium ion (GO:0005513)2.99419667
106axonal fasciculation (GO:0007413)2.98909577
107regulation of vesicle fusion (GO:0031338)2.98365761
108regulation of beta-amyloid formation (GO:1902003)2.97905927
109regulation of dendritic spine morphogenesis (GO:0061001)2.97105144
110regulation of dendritic spine development (GO:0060998)2.95497601
111regulation of neurotransmitter transport (GO:0051588)2.95449460
112behavioral response to cocaine (GO:0048148)2.94250617
113regulation of voltage-gated calcium channel activity (GO:1901385)2.94102960
114positive regulation of neurotransmitter secretion (GO:0001956)2.94066093
115positive regulation of synapse maturation (GO:0090129)2.93869068
116regulation of calcium ion-dependent exocytosis (GO:0017158)2.93027598
117postsynaptic membrane organization (GO:0001941)2.92711178
118regulation of synaptic transmission (GO:0050804)2.90988386
119membrane repolarization (GO:0086009)2.87457899
120neuronal ion channel clustering (GO:0045161)2.84745314
121synapse assembly (GO:0007416)2.84019605
122mechanosensory behavior (GO:0007638)2.83697270
123regulation of membrane repolarization (GO:0060306)2.83255525
124membrane depolarization (GO:0051899)2.83180346
125positive regulation of synaptic transmission, GABAergic (GO:0032230)2.82678968

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.49613509
2GBX2_23144817_ChIP-Seq_PC3_Human3.28686681
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.07617647
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.03988123
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.88538683
6RNF2_18974828_ChIP-Seq_MESCs_Mouse2.67341304
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.67341304
8* REST_21632747_ChIP-Seq_MESCs_Mouse2.65398833
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.60819446
10SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.60619964
11DROSHA_22980978_ChIP-Seq_HELA_Human2.57124096
12MTF2_20144788_ChIP-Seq_MESCs_Mouse2.51883081
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.49664211
14* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.47761939
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.44362179
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.35566792
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.35154101
18* RARB_27405468_Chip-Seq_BRAIN_Mouse2.29264467
19RNF2_27304074_Chip-Seq_ESCs_Mouse2.24239486
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.22119485
21EZH2_27294783_Chip-Seq_ESCs_Mouse2.20978981
22IKZF1_21737484_ChIP-ChIP_HCT116_Human2.17615697
23* REST_18959480_ChIP-ChIP_MESCs_Mouse2.07615235
24AR_21572438_ChIP-Seq_LNCaP_Human2.05153363
25MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.83292353
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.76218304
27ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.73470712
28EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.70942316
29CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.67638215
30IGF1R_20145208_ChIP-Seq_DFB_Human1.60730074
31SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.58408097
32NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.58124042
33SMAD4_21799915_ChIP-Seq_A2780_Human1.57630012
34* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.56373891
35ERG_21242973_ChIP-ChIP_JURKAT_Human1.53678381
36CTBP1_25329375_ChIP-Seq_LNCAP_Human1.50784334
37GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.47744880
38VDR_22108803_ChIP-Seq_LS180_Human1.43227058
39RING1B_27294783_Chip-Seq_ESCs_Mouse1.40725798
40PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.38152814
41CBX2_27304074_Chip-Seq_ESCs_Mouse1.35979638
42RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.34519478
43PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.33739342
44PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.31619855
45P300_19829295_ChIP-Seq_ESCs_Human1.30799608
46ZFP57_27257070_Chip-Seq_ESCs_Mouse1.28844715
47SMAD_19615063_ChIP-ChIP_OVARY_Human1.28548304
48RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.28276997
49TAF15_26573619_Chip-Seq_HEK293_Human1.27251345
50TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.26671190
51SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.24667062
52CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.24029596
53AR_25329375_ChIP-Seq_VCAP_Human1.23251448
54* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.22871452
55* SOX2_21211035_ChIP-Seq_LN229_Gbm1.22645013
56* AR_19668381_ChIP-Seq_PC3_Human1.22620849
57FLI1_27457419_Chip-Seq_LIVER_Mouse1.21200297
58PIAS1_25552417_ChIP-Seq_VCAP_Human1.19855725
59SMAD3_21741376_ChIP-Seq_EPCs_Human1.19689477
60ZNF274_21170338_ChIP-Seq_K562_Hela1.19567405
61NR3C1_23031785_ChIP-Seq_PC12_Mouse1.18419039
62STAT3_23295773_ChIP-Seq_U87_Human1.18125376
63CDX2_19796622_ChIP-Seq_MESCs_Mouse1.18106012
64MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.17086433
65WT1_25993318_ChIP-Seq_PODOCYTE_Human1.14339950
66SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14037974
67FUS_26573619_Chip-Seq_HEK293_Human1.11934098
68TOP2B_26459242_ChIP-Seq_MCF-7_Human1.11688814
69NR3C1_21868756_ChIP-Seq_MCF10A_Human1.09478469
70* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09396052
71OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09082179
72DNAJC2_21179169_ChIP-ChIP_NT2_Human1.08239970
73RING1B_27294783_Chip-Seq_NPCs_Mouse1.06710531
74ER_23166858_ChIP-Seq_MCF-7_Human1.05157750
75NANOG_18555785_Chip-Seq_ESCs_Mouse1.04901629
76FLI1_21867929_ChIP-Seq_TH2_Mouse1.04492234
77ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.03764050
78* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02204547
79TCF4_23295773_ChIP-Seq_U87_Human1.02112393
80YAP1_20516196_ChIP-Seq_MESCs_Mouse1.01859787
81P53_22127205_ChIP-Seq_FIBROBLAST_Human1.01227412
82MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.01206173
83ZNF217_24962896_ChIP-Seq_MCF-7_Human1.00948157
84ARNT_22903824_ChIP-Seq_MCF-7_Human0.99170787
85BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.98171594
86* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98112482
87KDM2B_26808549_Chip-Seq_REH_Human0.98027438
88AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.97495515
89KDM2B_26808549_Chip-Seq_K562_Human0.97320036
90CBP_20019798_ChIP-Seq_JUKART_Human0.97109373
91IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.97109373
92RXR_22108803_ChIP-Seq_LS180_Human0.96445195
93RNF2_27304074_Chip-Seq_NSC_Mouse0.96065476
94POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.95422776
95TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95422776
96BMI1_23680149_ChIP-Seq_NPCS_Mouse0.94988157
97P53_22387025_ChIP-Seq_ESCs_Mouse0.94680383
98LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94104116
99TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.93877853
100SMAD4_21741376_ChIP-Seq_HESCs_Human0.93695731
101SMAD3_21741376_ChIP-Seq_ESCs_Human0.93261341
102EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.93230864
103PCGF2_27294783_Chip-Seq_ESCs_Mouse0.92696512
104* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.92627711
105* RUNX2_22187159_ChIP-Seq_PCA_Human0.92325225
106TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91569373
107SMAD4_21741376_ChIP-Seq_EPCs_Human0.90861082
108* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.90594234
109AHR_22903824_ChIP-Seq_MCF-7_Human0.90492728
110* TCF4_22108803_ChIP-Seq_LS180_Human0.90384873
111* BCAT_22108803_ChIP-Seq_LS180_Human0.89667529
112JUN_21703547_ChIP-Seq_K562_Human0.89409615
113SMAD3_21741376_ChIP-Seq_HESCs_Human0.88150215
114TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.86633722
115TP53_16413492_ChIP-PET_HCT116_Human0.86528293
116POU3F2_20337985_ChIP-ChIP_501MEL_Human0.84697578
117* PRDM14_20953172_ChIP-Seq_ESCs_Human0.84341277
118TET1_21490601_ChIP-Seq_MESCs_Mouse0.83762828
119TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.83574011
120WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.82567012
121THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.81902874
122ZFP281_18757296_ChIP-ChIP_E14_Mouse0.81678852
123TP53_20018659_ChIP-ChIP_R1E_Mouse0.81284216

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.56235756
2MP0003880_abnormal_central_pattern3.92001567
3MP0003635_abnormal_synaptic_transmissio3.81607112
4MP0004270_analgesia3.37604214
5MP0009046_muscle_twitch3.31497105
6MP0009745_abnormal_behavioral_response3.12098509
7MP0001984_abnormal_olfaction3.10060989
8MP0005423_abnormal_somatic_nervous3.09964855
9MP0002064_seizures2.99631790
10MP0002063_abnormal_learning/memory/cond2.97512910
11MP0001486_abnormal_startle_reflex2.85660954
12MP0002572_abnormal_emotion/affect_behav2.62956886
13MP0002272_abnormal_nervous_system2.53692302
14MP0001968_abnormal_touch/_nociception2.52821473
15MP0005646_abnormal_pituitary_gland2.49063312
16MP0002734_abnormal_mechanical_nocicepti2.47691920
17MP0002822_catalepsy2.43146039
18MP0003329_amyloid_beta_deposits2.25283848
19MP0004147_increased_porphyrin_level2.25046626
20MP0008569_lethality_at_weaning2.13869531
21MP0001440_abnormal_grooming_behavior2.12510046
22MP0001501_abnormal_sleep_pattern2.08799928
23MP0004885_abnormal_endolymph2.03727513
24MP0004858_abnormal_nervous_system2.02269661
25MP0002067_abnormal_sensory_capabilities1.97905468
26MP0002736_abnormal_nociception_after1.96043535
27MP0005551_abnormal_eye_electrophysiolog1.95412049
28MP0003690_abnormal_glial_cell1.91235637
29MP0002733_abnormal_thermal_nociception1.88588972
30MP0001502_abnormal_circadian_rhythm1.82007125
31MP0009780_abnormal_chondrocyte_physiolo1.81538019
32MP0001970_abnormal_pain_threshold1.78613551
33MP0002557_abnormal_social/conspecific_i1.76924744
34MP0002909_abnormal_adrenal_gland1.74478067
35MP0002735_abnormal_chemical_nociception1.71344914
36MP0000778_abnormal_nervous_system1.65738030
37MP0002184_abnormal_innervation1.65206499
38MP0005386_behavior/neurological_phenoty1.61877296
39MP0004924_abnormal_behavior1.61877296
40MP0003633_abnormal_nervous_system1.60614927
41MP0000569_abnormal_digit_pigmentation1.55604528
42MP0005645_abnormal_hypothalamus_physiol1.52627807
43MP0002882_abnormal_neuron_morphology1.50682121
44MP0000955_abnormal_spinal_cord1.45578323
45MP0001986_abnormal_taste_sensitivity1.44780499
46MP0008877_abnormal_DNA_methylation1.43371617
47MP0004811_abnormal_neuron_physiology1.43071831
48MP0004142_abnormal_muscle_tone1.41741455
49MP0002638_abnormal_pupillary_reflex1.36776210
50MP0002066_abnormal_motor_capabilities/c1.34507330
51MP0003631_nervous_system_phenotype1.32229290
52MP0003634_abnormal_glial_cell1.30012999
53MP0005253_abnormal_eye_physiology1.24462009
54MP0006276_abnormal_autonomic_nervous1.24194820
55MP0002229_neurodegeneration1.21480744
56MP0001529_abnormal_vocalization1.18452660
57MP0002090_abnormal_vision1.14915038
58MP0002152_abnormal_brain_morphology1.14349777
59MP0004145_abnormal_muscle_electrophysio1.14192588
60MP0001485_abnormal_pinna_reflex1.13811868
61MP0001905_abnormal_dopamine_level1.13198280
62MP0000751_myopathy1.12486875
63MP0003879_abnormal_hair_cell1.10495254
64MP0003075_altered_response_to1.09487319
65MP0005394_taste/olfaction_phenotype1.06607594
66MP0005499_abnormal_olfactory_system1.06607594
67MP0004215_abnormal_myocardial_fiber1.05982848
68MP0006072_abnormal_retinal_apoptosis1.05978829
69MP0003137_abnormal_impulse_conducting1.02138215
70MP0003632_abnormal_nervous_system1.01811216
71MP0000604_amyloidosis1.01721018
72MP0002752_abnormal_somatic_nervous0.99352486
73MP0001963_abnormal_hearing_physiology0.97911600
74MP0010386_abnormal_urinary_bladder0.96549126
75MP0003011_delayed_dark_adaptation0.92430922
76MP0004742_abnormal_vestibular_system0.90328617
77MP0004043_abnormal_pH_regulation0.88884170
78MP0000631_abnormal_neuroendocrine_gland0.88251521
79MP0004130_abnormal_muscle_cell0.87788146
80MP0001299_abnormal_eye_distance/0.81925477
81MP0001177_atelectasis0.81862900
82MP0008872_abnormal_physiological_respon0.81722573
83MP0005410_abnormal_fertilization0.81546735
84MP0002069_abnormal_eating/drinking_beha0.80361829
85MP0002876_abnormal_thyroid_physiology0.80267063
86MP0000920_abnormal_myelination0.78954655
87MP0003646_muscle_fatigue0.78045913
88MP0002837_dystrophic_cardiac_calcinosis0.76563493
89MP0002653_abnormal_ependyma_morphology0.75298391
90MP0004085_abnormal_heartbeat0.75117955
91MP0008874_decreased_physiological_sensi0.74137739
92MP0003121_genomic_imprinting0.73212539
93MP0003123_paternal_imprinting0.72990325
94MP0004233_abnormal_muscle_weight0.72919928
95MP0003136_yellow_coat_color0.72591122
96MP0005535_abnormal_body_temperature0.72210008
97MP0000013_abnormal_adipose_tissue0.72190018
98MP0003787_abnormal_imprinting0.71472904
99MP0005167_abnormal_blood-brain_barrier0.70391889
100MP0003195_calcinosis0.68116080
101MP0005195_abnormal_posterior_eye0.63593358
102MP0000026_abnormal_inner_ear0.62906474
103MP0003122_maternal_imprinting0.62103730
104MP0008875_abnormal_xenobiotic_pharmacok0.62038468
105MP0005174_abnormal_tail_pigmentation0.60655037
106MP0004133_heterotaxia0.60518932
107MP0001188_hyperpigmentation0.59497930
108MP0003172_abnormal_lysosome_physiology0.57619041
109MP0003878_abnormal_ear_physiology0.55857968
110MP0005377_hearing/vestibular/ear_phenot0.55857968
111MP0005623_abnormal_meninges_morphology0.54105531
112MP0001943_abnormal_respiration0.53674884
113MP0002102_abnormal_ear_morphology0.53101806
114MP0003861_abnormal_nervous_system0.52927750
115MP0002089_abnormal_postnatal_growth/wei0.52819179
116MP0001664_abnormal_digestion0.52729134
117MP0001765_abnormal_ion_homeostasis0.50781845
118MP0003045_fibrosis0.49592084
119MP0003283_abnormal_digestive_organ0.49281774
120MP0010769_abnormal_survival0.47471118

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.00994614
2Myokymia (HP:0002411)5.91558988
3Focal seizures (HP:0007359)5.09129712
4Epileptic encephalopathy (HP:0200134)4.63299345
5Visual hallucinations (HP:0002367)4.38291939
6Febrile seizures (HP:0002373)4.13758782
7Megalencephaly (HP:0001355)4.09928430
8Progressive cerebellar ataxia (HP:0002073)4.07491834
9Hemiparesis (HP:0001269)4.03890495
10Action tremor (HP:0002345)3.98782207
11Atonic seizures (HP:0010819)3.94485597
12Aplasia involving bones of the upper limbs (HP:0009823)3.82680965
13Aplasia of the phalanges of the hand (HP:0009802)3.82680965
14Aplasia involving bones of the extremities (HP:0009825)3.82680965
15Generalized tonic-clonic seizures (HP:0002069)3.70410353
16Absence seizures (HP:0002121)3.65436840
17Diplopia (HP:0000651)3.64003997
18Abnormality of binocular vision (HP:0011514)3.64003997
19Supranuclear gaze palsy (HP:0000605)3.61238382
20Hemiplegia (HP:0002301)3.48523222
21Dialeptic seizures (HP:0011146)3.45266950
22Dysdiadochokinesis (HP:0002075)3.44732024
23Neurofibrillary tangles (HP:0002185)3.28190603
24Truncal ataxia (HP:0002078)3.08974881
25Depression (HP:0000716)3.00088259
26Postural instability (HP:0002172)2.94911641
27Abnormal eating behavior (HP:0100738)2.94398027
28Gaze-evoked nystagmus (HP:0000640)2.88924036
29Ankle clonus (HP:0011448)2.82907641
30Dysmetria (HP:0001310)2.79789994
31Broad-based gait (HP:0002136)2.75615629
32Cerebral inclusion bodies (HP:0100314)2.70355384
33Status epilepticus (HP:0002133)2.69293201
34Anxiety (HP:0000739)2.67455233
35Impaired vibration sensation in the lower limbs (HP:0002166)2.60027337
36Hyperventilation (HP:0002883)2.59157165
37Intention tremor (HP:0002080)2.56575350
38Poor eye contact (HP:0000817)2.48845172
39Absent speech (HP:0001344)2.46999693
40Increased circulating renin level (HP:0000848)2.42583034
41Impaired smooth pursuit (HP:0007772)2.41220633
42Inability to walk (HP:0002540)2.40760256
43Cerebral hypomyelination (HP:0006808)2.39680816
44Abnormality of the corticospinal tract (HP:0002492)2.38397729
45Impaired social interactions (HP:0000735)2.36451661
46Abnormal social behavior (HP:0012433)2.36451661
47Bradykinesia (HP:0002067)2.34731064
48Scanning speech (HP:0002168)2.32124553
49Urinary bladder sphincter dysfunction (HP:0002839)2.26759017
50Akinesia (HP:0002304)2.25126938
51Abnormality of ocular smooth pursuit (HP:0000617)2.23975024
52Morphological abnormality of the pyramidal tract (HP:0002062)2.22072841
53Degeneration of the lateral corticospinal tracts (HP:0002314)2.20404282
54Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.20404282
55Genetic anticipation (HP:0003743)2.19479192
56Clumsiness (HP:0002312)2.19035098
57Central scotoma (HP:0000603)2.18265925
58Mutism (HP:0002300)2.13029292
59Scotoma (HP:0000575)2.12767646
60Torticollis (HP:0000473)2.11542502
61Pheochromocytoma (HP:0002666)2.11033835
62Epileptiform EEG discharges (HP:0011182)2.10991551
63Stereotypic behavior (HP:0000733)2.10815794
64Humeroradial synostosis (HP:0003041)2.10704851
65Synostosis involving the elbow (HP:0003938)2.10704851
66Delusions (HP:0000746)2.10134365
67Confusion (HP:0001289)2.09392135
68Polyphagia (HP:0002591)2.09336673
69Ventricular fibrillation (HP:0001663)2.08475212
70Drooling (HP:0002307)2.08243697
71Excessive salivation (HP:0003781)2.08243697
72EEG with generalized epileptiform discharges (HP:0011198)2.07678595
73Decreased central vision (HP:0007663)2.05821651
74Gait imbalance (HP:0002141)2.05308148
75Spastic gait (HP:0002064)2.04373129
76Retinal dysplasia (HP:0007973)2.03526110
77Lower limb muscle weakness (HP:0007340)2.03148323
78Polydipsia (HP:0001959)2.03047751
79Abnormal drinking behavior (HP:0030082)2.03047751
80Sleep apnea (HP:0010535)2.03009386
81Abnormality of the lower motor neuron (HP:0002366)2.02770476
82Urinary urgency (HP:0000012)2.01234310
83Exercise-induced myalgia (HP:0003738)1.98814332
84Amblyopia (HP:0000646)1.98574013
85Progressive inability to walk (HP:0002505)1.96908098
86Hypsarrhythmia (HP:0002521)1.96882174
87Abnormality of macular pigmentation (HP:0008002)1.96731678
88Type II lissencephaly (HP:0007260)1.95597494
89Neuroendocrine neoplasm (HP:0100634)1.94578012
90Focal dystonia (HP:0004373)1.93750909
91Metabolic alkalosis (HP:0200114)1.91858006
92Tetraplegia (HP:0002445)1.91545756
93Rigidity (HP:0002063)1.91147564
94Molar tooth sign on MRI (HP:0002419)1.91144229
95Abnormality of midbrain morphology (HP:0002418)1.91144229
96Congenital stationary night blindness (HP:0007642)1.90062179
97Limb dystonia (HP:0002451)1.89734146
98Prolonged QT interval (HP:0001657)1.88875289
99Impaired vibratory sensation (HP:0002495)1.88586286
100Generalized myoclonic seizures (HP:0002123)1.88459003
101Protruding tongue (HP:0010808)1.88190229
102Medial flaring of the eyebrow (HP:0010747)1.86785154
103Dyskinesia (HP:0100660)1.84764079
104Pancreatic fibrosis (HP:0100732)1.84273547
105Pancreatic cysts (HP:0001737)1.84087217
106Dysmetric saccades (HP:0000641)1.83151905
107Papilledema (HP:0001085)1.82982385
108Abnormal EKG (HP:0003115)1.82310710
109Agitation (HP:0000713)1.82146244
110Spastic tetraplegia (HP:0002510)1.81707086
111Annular pancreas (HP:0001734)1.81179426
112Gait ataxia (HP:0002066)1.80960175
113True hermaphroditism (HP:0010459)1.80862650
114CNS hypomyelination (HP:0003429)1.80777806
115Insomnia (HP:0100785)1.80614587
116Clonus (HP:0002169)1.79530138
117Neuronal loss in central nervous system (HP:0002529)1.79100672
118Narrow nasal bridge (HP:0000446)1.78531981
119Congenital primary aphakia (HP:0007707)1.78529749
120Abnormality of saccadic eye movements (HP:0000570)1.78323852
121Nephronophthisis (HP:0000090)1.78321448
122Fetal akinesia sequence (HP:0001989)1.78277257
123Split foot (HP:0001839)1.77222709
124Specific learning disability (HP:0001328)1.76695929
125Obstructive sleep apnea (HP:0002870)1.74573285
126Incomplete penetrance (HP:0003829)1.72434210
127Spinal canal stenosis (HP:0003416)1.71171412
128Limb ataxia (HP:0002070)1.70855942
129Craniofacial dystonia (HP:0012179)1.69403596
130Dynein arm defect of respiratory motile cilia (HP:0012255)1.69396674
131Absent/shortened dynein arms (HP:0200106)1.69396674

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.56306527
2NTRK34.01812675
3MAP3K92.95109101
4FRK2.91986394
5NTRK22.83047531
6MAP3K42.68831416
7PHKG12.68178898
8PHKG22.68178898
9MARK12.59256139
10MINK12.51172861
11TNIK2.48841324
12LMTK22.46671934
13PRKD32.41040433
14MAP2K72.26814685
15PAK62.05007202
16DAPK21.95480773
17CAMKK11.78542199
18CASK1.72509952
19MAP2K41.64345951
20STK381.56833596
21NTRK11.50935135
22CDK51.46881967
23MAPK131.45820960
24KSR21.44960742
25PINK11.38717781
26MUSK1.37540231
27PRKCG1.35127538
28PRPF4B1.32984743
29ADRBK21.30734918
30RIPK41.30343900
31CAMKK21.28363111
32SGK2231.28280769
33SGK4941.28280769
34MAP3K121.23934644
35SGK21.22383475
36GRK51.14146698
37TYRO31.11042828
38KSR11.09884994
39SIK21.04946370
40FES1.04640622
41PNCK1.03030420
42SGK31.02053519
43MAP4K20.98238207
44CDK190.96750052
45CAMK2A0.96487168
46GRK10.96357818
47PLK20.96021815
48DAPK10.94982291
49MAP3K130.94222778
50ARAF0.89938577
51WNK40.88436248
52PRKCH0.88246600
53BMPR1B0.86718080
54CAMK10.85791028
55TAOK30.84404850
56DYRK1A0.83703956
57WNK10.83522476
58UHMK10.83506407
59WNK30.82328837
60STK390.82206734
61PKN10.81914857
62CAMK2B0.80373443
63STK110.79768346
64PAK30.79402625
65CDK150.78707234
66CDK180.77804055
67MAP3K20.74656508
68TNK20.73111774
69CDK140.71964350
70SGK10.71564050
71CAMK2G0.71346854
72MAPK120.69913720
73CDC42BPA0.68383004
74CDK11A0.66841125
75DYRK20.66037352
76INSRR0.64919727
77MARK20.64548600
78CAMK1G0.63898736
79CAMK2D0.62811529
80MAP3K70.61084025
81TXK0.60864247
82PDK40.59536156
83PDK30.59536156
84OXSR10.59080766
85PRKCE0.58578513
86RPS6KA30.57961852
87PDPK10.57882415
88PDK10.57791653
89RET0.57488408
90MAP2K60.57431901
91RIPK10.55407311
92TAOK10.54461161
93NEK10.53565885
94NEK60.52486596
95MAP3K110.52004068
96PIK3CA0.49623047
97CSNK1G20.48960060
98PTK2B0.48345034
99MAPK100.46978409
100MAPKAPK50.46926083
101PRKCQ0.46794384
102LATS20.45277426
103PRKCZ0.44954157
104ROCK20.44900841
105TRIB30.44472607
106CAMK40.43790013
107CSNK1D0.42495072
108FYN0.41959254
109BMPR20.41900380
110FGFR20.41857288
111PRKCA0.41313891
112CSNK1A10.40916011
113CSNK1G30.40407449
114ADRBK10.39964144
115FGR0.39569071
116ALK0.39065700
117PRKACA0.38806567
118ROCK10.38546235
119CSNK1A1L0.36103052
120PRKG10.35802090
121ERBB20.35495022
122PRKCB0.35133105
123CSNK1G10.34258916
124MAP2K10.33427302

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.68445129
2Olfactory transduction_Homo sapiens_hsa047403.22177598
3Nitrogen metabolism_Homo sapiens_hsa009103.12745360
4Synaptic vesicle cycle_Homo sapiens_hsa047212.85505333
5GABAergic synapse_Homo sapiens_hsa047272.85211903
6Glutamatergic synapse_Homo sapiens_hsa047242.61591227
7Circadian entrainment_Homo sapiens_hsa047132.55023695
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.52011370
9Morphine addiction_Homo sapiens_hsa050322.44009850
10Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.37853373
11Salivary secretion_Homo sapiens_hsa049702.26312162
12Long-term potentiation_Homo sapiens_hsa047202.19855441
13Insulin secretion_Homo sapiens_hsa049112.16212143
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.14023104
15Amphetamine addiction_Homo sapiens_hsa050312.05166930
16Gastric acid secretion_Homo sapiens_hsa049712.01466989
17Dopaminergic synapse_Homo sapiens_hsa047281.82888700
18Taste transduction_Homo sapiens_hsa047421.73320631
19Cholinergic synapse_Homo sapiens_hsa047251.68916478
20Aldosterone synthesis and secretion_Homo sapiens_hsa049251.67071287
21Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.61444765
22Calcium signaling pathway_Homo sapiens_hsa040201.57636829
23Phototransduction_Homo sapiens_hsa047441.54452012
24Cocaine addiction_Homo sapiens_hsa050301.53567418
25Renin secretion_Homo sapiens_hsa049241.51882184
26Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.43997123
27Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.41542068
28Oxytocin signaling pathway_Homo sapiens_hsa049211.41123773
29Serotonergic synapse_Homo sapiens_hsa047261.39807442
30Long-term depression_Homo sapiens_hsa047301.38462885
31cAMP signaling pathway_Homo sapiens_hsa040241.32592120
32GnRH signaling pathway_Homo sapiens_hsa049121.23653848
33Gap junction_Homo sapiens_hsa045401.18020916
34Cardiac muscle contraction_Homo sapiens_hsa042601.14315373
35Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.12361864
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.05523673
37Phosphatidylinositol signaling system_Homo sapiens_hsa040701.04684199
38Collecting duct acid secretion_Homo sapiens_hsa049661.04125010
39Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.02800421
40Pancreatic secretion_Homo sapiens_hsa049721.01820529
41cGMP-PKG signaling pathway_Homo sapiens_hsa040221.00201845
42Bile secretion_Homo sapiens_hsa049760.98863813
43Butanoate metabolism_Homo sapiens_hsa006500.98289811
44Dorso-ventral axis formation_Homo sapiens_hsa043200.93855177
45Estrogen signaling pathway_Homo sapiens_hsa049150.92535091
46Melanogenesis_Homo sapiens_hsa049160.92449864
47Circadian rhythm_Homo sapiens_hsa047100.91572665
48Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.88145893
49Thyroid hormone synthesis_Homo sapiens_hsa049180.88094842
50Type II diabetes mellitus_Homo sapiens_hsa049300.86709941
51Carbohydrate digestion and absorption_Homo sapiens_hsa049730.84694973
52Phospholipase D signaling pathway_Homo sapiens_hsa040720.84012905
53Vascular smooth muscle contraction_Homo sapiens_hsa042700.81770486
54Dilated cardiomyopathy_Homo sapiens_hsa054140.81062603
55Axon guidance_Homo sapiens_hsa043600.77754489
56Linoleic acid metabolism_Homo sapiens_hsa005910.77715531
57Vitamin B6 metabolism_Homo sapiens_hsa007500.75835481
58Ether lipid metabolism_Homo sapiens_hsa005650.74959115
59Glioma_Homo sapiens_hsa052140.73814495
60* Fatty acid biosynthesis_Homo sapiens_hsa000610.72912013
61alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.71710264
62Regulation of autophagy_Homo sapiens_hsa041400.71569775
63Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.70877994
64Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.70489457
65Glucagon signaling pathway_Homo sapiens_hsa049220.68305748
66Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.68183930
67Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.67462888
68ErbB signaling pathway_Homo sapiens_hsa040120.66527512
69Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.65253201
70Thyroid hormone signaling pathway_Homo sapiens_hsa049190.63829689
71Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.62696153
72Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.62501407
73ABC transporters_Homo sapiens_hsa020100.61840615
74Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.59589272
75Choline metabolism in cancer_Homo sapiens_hsa052310.59585547
76Maturity onset diabetes of the young_Homo sapiens_hsa049500.58880195
77Oocyte meiosis_Homo sapiens_hsa041140.58507440
78Vibrio cholerae infection_Homo sapiens_hsa051100.56576495
79Mineral absorption_Homo sapiens_hsa049780.55207680
80Oxidative phosphorylation_Homo sapiens_hsa001900.54536549
81Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.54448247
82MAPK signaling pathway_Homo sapiens_hsa040100.54274005
83Histidine metabolism_Homo sapiens_hsa003400.54164692
84Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.53510160
85Glycerophospholipid metabolism_Homo sapiens_hsa005640.52625964
86beta-Alanine metabolism_Homo sapiens_hsa004100.50202051
87Inositol phosphate metabolism_Homo sapiens_hsa005620.48483346
88Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.46474433
89Sphingolipid signaling pathway_Homo sapiens_hsa040710.46396045
90Rap1 signaling pathway_Homo sapiens_hsa040150.45620352
91SNARE interactions in vesicular transport_Homo sapiens_hsa041300.43789641
92Alcoholism_Homo sapiens_hsa050340.40555147
93Ras signaling pathway_Homo sapiens_hsa040140.40520983
94Longevity regulating pathway - mammal_Homo sapiens_hsa042110.39984356
95Neurotrophin signaling pathway_Homo sapiens_hsa047220.39224258
96Type I diabetes mellitus_Homo sapiens_hsa049400.39219028
97Ovarian steroidogenesis_Homo sapiens_hsa049130.38683067
98Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.36021418
99Insulin signaling pathway_Homo sapiens_hsa049100.35386621
100Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.34629454
101Parkinsons disease_Homo sapiens_hsa050120.34126862
102Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.33377306
103Arginine biosynthesis_Homo sapiens_hsa002200.32372219
104Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.32068609
105Wnt signaling pathway_Homo sapiens_hsa043100.30534626
106Endocytosis_Homo sapiens_hsa041440.29789483
107mTOR signaling pathway_Homo sapiens_hsa041500.29770107
108Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.28166249
109Tryptophan metabolism_Homo sapiens_hsa003800.28103733
110African trypanosomiasis_Homo sapiens_hsa051430.28093535
111VEGF signaling pathway_Homo sapiens_hsa043700.26230089
112Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.24020218
113Glycerolipid metabolism_Homo sapiens_hsa005610.22593538
114Arginine and proline metabolism_Homo sapiens_hsa003300.22583613
115Fructose and mannose metabolism_Homo sapiens_hsa000510.22468963
116Alzheimers disease_Homo sapiens_hsa050100.22285543
117Prion diseases_Homo sapiens_hsa050200.21575676

Most similar genes based on co-expression Upload to Enrichr

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