ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	7.56894450
2	L-phenylalanine catabolic process (GO:0006559)	7.56894450
3	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	7.26726324
4	L-phenylalanine metabolic process (GO:0006558)	7.26726324
5	aromatic amino acid family catabolic process (GO:0009074)	6.95487239
6	indole-containing compound catabolic process (GO:0042436)	6.42355990
7	indolalkylamine catabolic process (GO:0046218)	6.42355990
8	tryptophan catabolic process (GO:0006569)	6.42355990
9	kynurenine metabolic process (GO:0070189)	6.17973431
10	glyoxylate metabolic process (GO:0046487)	6.06564214
11	tryptophan metabolic process (GO:0006568)	6.02780251
12	bile acid biosynthetic process (GO:0006699)	5.95524623
13	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	5.90865379
14	cysteine metabolic process (GO:0006534)	5.65542996
15	urea metabolic process (GO:0019627)	5.49346322
16	urea cycle (GO:0000050)	5.49346322
17	alpha-linolenic acid metabolic process (GO:0036109)	5.40440537
18	negative regulation of fibrinolysis (GO:0051918)	5.37632852
19	sulfur amino acid catabolic process (GO:0000098)	5.33675425
20	epoxygenase P450 pathway (GO:0019373)	5.29402609
21	high-density lipoprotein particle remodeling (GO:0034375)	5.25260654
22	serine family amino acid catabolic process (GO:0009071)	5.25042711
23	complement activation, alternative pathway (GO:0006957)	5.20990477
24	protein carboxylation (GO:0018214)	5.18371571
25	peptidyl-glutamic acid carboxylation (GO:0017187)	5.18371571
26	regulation of fibrinolysis (GO:0051917)	5.17443237
27	regulation of protein activation cascade (GO:2000257)	5.17022449
28	lysine metabolic process (GO:0006553)	5.10259968
29	lysine catabolic process (GO:0006554)	5.10259968
30	fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)	5.09678383
31	nitrogen cycle metabolic process (GO:0071941)	5.06536770
32	aromatic amino acid family metabolic process (GO:0009072)	5.05853372
33	bile acid metabolic process (GO:0008206)	5.03388177
34	homocysteine metabolic process (GO:0050667)	4.88252964
35	regulation of complement activation (GO:0030449)	4.83516347
36	tyrosine metabolic process (GO:0006570)	4.72825091
37	amino-acid betaine metabolic process (GO:0006577)	4.72266345
38	alpha-amino acid catabolic process (GO:1901606)	4.71426264
39	regulation of lipoprotein metabolic process (GO:0050746)	4.69959554
40	ethanol metabolic process (GO:0006067)	4.69684306
41	negative regulation of protein activation cascade (GO:2000258)	4.66933244
42	regulation of cholesterol esterification (GO:0010872)	4.63316245
43	negative regulation of complement activation (GO:0045916)	4.62545238
44	regulation of triglyceride catabolic process (GO:0010896)	4.56011727
45	sodium-independent organic anion transport (GO:0043252)	4.55650095
46	indolalkylamine metabolic process (GO:0006586)	4.53844547
47	reverse cholesterol transport (GO:0043691)	4.53015088
48	cellular ketone body metabolic process (GO:0046950)	4.49509034
49	plasma lipoprotein particle remodeling (GO:0034369)	4.49280824
50	protein-lipid complex remodeling (GO:0034368)	4.49280824
51	macromolecular complex remodeling (GO:0034367)	4.49280824
52	purine nucleotide transport (GO:0015865)	4.48366589
53	negative regulation of cholesterol transport (GO:0032375)	4.44915563
54	negative regulation of sterol transport (GO:0032372)	4.44915563
55	amine catabolic process (GO:0009310)	4.43482116
56	cellular biogenic amine catabolic process (GO:0042402)	4.43482116
57	triglyceride homeostasis (GO:0070328)	4.39676921
58	acylglycerol homeostasis (GO:0055090)	4.39676921
59	primary alcohol catabolic process (GO:0034310)	4.39315929
60	coenzyme catabolic process (GO:0009109)	4.38138230
61	phenylpropanoid metabolic process (GO:0009698)	4.37507466
62	cellular amino acid catabolic process (GO:0009063)	4.36893920
63	glycine metabolic process (GO:0006544)	4.36074134
64	serine family amino acid metabolic process (GO:0009069)	4.35783534
65	glutamate metabolic process (GO:0006536)	4.35693846
66	cellular glucuronidation (GO:0052695)	4.33245742
67	phospholipid efflux (GO:0033700)	4.29897868
68	oxidative demethylation (GO:0070989)	4.28895586
69	bile acid and bile salt transport (GO:0015721)	4.27550219
70	drug catabolic process (GO:0042737)	4.25095838
71	cellular modified amino acid catabolic process (GO:0042219)	4.24771650
72	positive regulation of chemokine secretion (GO:0090197)	4.23835383
73	ethanol oxidation (GO:0006069)	4.19133393
74	imidazole-containing compound metabolic process (GO:0052803)	4.16217957
75	hormone catabolic process (GO:0042447)	4.14920221
76	plasma lipoprotein particle clearance (GO:0034381)	4.14833776
77	serine family amino acid biosynthetic process (GO:0009070)	4.12332070
78	biotin metabolic process (GO:0006768)	4.05153361
79	dicarboxylic acid biosynthetic process (GO:0043650)	4.04788680
80	urate metabolic process (GO:0046415)	4.04731301
81	* benzene-containing compound metabolic process (GO:0042537)	4.03337357
82	aldehyde catabolic process (GO:0046185)	4.02978545
83	drug metabolic process (GO:0017144)	4.02580107
84	drug transmembrane transport (GO:0006855)	4.01949514
85	cholesterol efflux (GO:0033344)	3.95608372
86	retinal metabolic process (GO:0042574)	3.94144940
87	arginine metabolic process (GO:0006525)	3.93648920
88	uronic acid metabolic process (GO:0006063)	3.90454857
89	glucuronate metabolic process (GO:0019585)	3.90454857
90	ketone body metabolic process (GO:1902224)	3.89253893
91	omega-hydroxylase P450 pathway (GO:0097267)	3.88960330
92	fibrinolysis (GO:0042730)	3.87400893
93	acetyl-CoA metabolic process (GO:0006084)	3.86118403
94	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)	3.85955887
95	organic acid catabolic process (GO:0016054)	3.82486116
96	carboxylic acid catabolic process (GO:0046395)	3.82486116
97	exogenous drug catabolic process (GO:0042738)	3.81239576
98	S-adenosylmethionine metabolic process (GO:0046500)	3.81187746
99	plasma lipoprotein particle assembly (GO:0034377)	3.77591030
100	low-density lipoprotein particle remodeling (GO:0034374)	3.76137061
101	aspartate family amino acid catabolic process (GO:0009068)	3.73973823
102	cofactor catabolic process (GO:0051187)	3.72758016
103	regulation of bile acid biosynthetic process (GO:0070857)	3.71841804
104	negative regulation of humoral immune response (GO:0002921)	3.70343864
105	regulation of cholesterol homeostasis (GO:2000188)	3.66798595
106	regulation of plasminogen activation (GO:0010755)	3.65647858
107	complement activation, classical pathway (GO:0006958)	3.64616791
108	positive regulation of cellular amine metabolic process (GO:0033240)	3.63998709
109	blood coagulation, intrinsic pathway (GO:0007597)	3.63605106
110	2-oxoglutarate metabolic process (GO:0006103)	3.63062761
111	phospholipid homeostasis (GO:0055091)	3.59929182
112	complement activation (GO:0006956)	3.59818741
113	cytolysis (GO:0019835)	3.59609242
114	flavonoid metabolic process (GO:0009812)	3.59194759
115	very-low-density lipoprotein particle assembly (GO:0034379)	3.59035968
116	positive regulation of lipoprotein lipase activity (GO:0051006)	3.57783646
117	positive regulation of triglyceride lipase activity (GO:0061365)	3.57783646
118	primary alcohol metabolic process (GO:0034308)	3.57494032
119	heme transport (GO:0015886)	3.57009758
120	regulation of chemokine secretion (GO:0090196)	3.56871889
121	positive regulation of lipid catabolic process (GO:0050996)	3.56251127
122	protein activation cascade (GO:0072376)	3.56235478
123	linoleic acid metabolic process (GO:0043651)	3.55717429
124	NAD biosynthetic process (GO:0009435)	3.55465774
125	carnitine metabolic process (GO:0009437)	3.52898247
126	phosphatidylethanolamine biosynthetic process (GO:0006646)	3.46759492
127	positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)	3.34155119
128	regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)	3.34155119
129	regulation of cytokine production involved in inflammatory response (GO:1900015)	3.32531227
130	drug transport (GO:0015893)	3.30052623
131	response to mercury ion (GO:0046689)	3.25957785
132	valine metabolic process (GO:0006573)	3.21292140
133	regulation of humoral immune response (GO:0002920)	3.20856093
134	phosphatidylethanolamine metabolic process (GO:0046337)	3.17751765
135	branched-chain amino acid metabolic process (GO:0009081)	3.16556249
136	regulation of apoptotic cell clearance (GO:2000425)	3.16256836
137	monocarboxylic acid catabolic process (GO:0072329)	3.10709382
138	lung lobe morphogenesis (GO:0060463)	3.05804342
139	alkaloid metabolic process (GO:0009820)	3.04203321
140	disruption of cells of other organism involved in symbiotic interaction (GO:0051818)	3.03080373
141	killing of cells in other organism involved in symbiotic interaction (GO:0051883)	3.03080373
142	* short-chain fatty acid metabolic process (GO:0046459)	3.03046606
143	negative regulation of hemostasis (GO:1900047)	3.02365183
144	negative regulation of blood coagulation (GO:0030195)	3.02365183
145	acute-phase response (GO:0006953)	3.01594087
146	* xenobiotic metabolic process (GO:0006805)	3.01494916
147	steroid catabolic process (GO:0006706)	3.00963368
148	lung vasculature development (GO:0060426)	2.99874335
149	* fatty acid oxidation (GO:0019395)	2.97898962
150	negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)	2.97643131

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	* RXR_22158963_ChIP-Seq_LIVER_Mouse	8.33463323
2	* PPARA_22158963_ChIP-Seq_LIVER_Mouse	7.14587825
3	EGR1_23403033_ChIP-Seq_LIVER_Mouse	6.93257763
4	* LXR_22158963_ChIP-Seq_LIVER_Mouse	6.44038689
5	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	5.18302704
6	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	4.97798108
7	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	4.90598227
8	* NR1I2_20693526_ChIP-Seq_LIVER_Mouse	3.97908476
9	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	3.97901932
10	PIAS1_25552417_ChIP-Seq_VCAP_Human	2.54093648
11	TCF7L2_21901280_ChIP-Seq_H4IIE_Rat	2.09980996
12	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	2.07315417
13	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	2.07139932
14	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.05491313
15	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	11.8445717
16	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.70671127
17	AR_21909140_ChIP-Seq_LNCAP_Human	1.63730249
18	* FOXA2_19822575_ChIP-Seq_HepG2_Human	1.61518435
19	CLOCK_20551151_ChIP-Seq_293T_Human	1.57852053
20	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.53751357
21	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.53443017
22	HTT_18923047_ChIP-ChIP_STHdh_Human	1.44666758
23	* HNF4A_19822575_ChIP-Seq_HepG2_Human	1.44061340
24	AHR_22903824_ChIP-Seq_MCF-7_Human	1.42849281
25	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.41146436
26	* GATA3_24758297_ChIP-Seq_MCF-7_Human	1.32852128
27	GATA1_22025678_ChIP-Seq_K562_Human	1.31760831
28	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.24598480
29	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	1.24551968
30	* FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.22336368
31	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.21815092
32	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.20846609
33	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.18613341
34	RXRA_24833708_ChIP-Seq_LIVER_Mouse	1.18472498
35	PHF8_20622853_ChIP-Seq_HELA_Human	1.16549885
36	ER_23166858_ChIP-Seq_MCF-7_Human	1.16305731
37	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.15980977
38	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.15577493
39	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.13628948
40	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.11915769
41	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.11668293
42	RXR_22108803_ChIP-Seq_LS180_Human	1.09166368
43	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.09048473
44	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.07554653
45	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.07190262
46	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.06638423
47	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.06368141
48	ETV1_20927104_ChIP-Seq_GIST48_Human	1.04676219
49	IGF1R_20145208_ChIP-Seq_DFB_Human	1.03395957
50	ERA_21632823_ChIP-Seq_H3396_Human	1.01326016
51	NFYA_21822215_ChIP-Seq_K562_Human	1.01095886
52	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	0.99929816
53	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.98947367
54	SOX2_18555785_Chip-Seq_ESCs_Mouse	0.98402346
55	ESR1_15608294_ChIP-ChIP_MCF-7_Human	0.98370434
56	KLF4_18555785_Chip-Seq_ESCs_Mouse	0.97979549
57	ZFX_18555785_Chip-Seq_ESCs_Mouse	0.97806982
58	RARG_19884340_ChIP-ChIP_MEFs_Mouse	0.97685535
59	ZNF274_21170338_ChIP-Seq_K562_Hela	0.97484688
60	TBL1_22424771_ChIP-Seq_293T_Human	0.97294565
61	* SOX2_27498859_Chip-Seq_STOMACH_Mouse	0.96163927
62	CDX2_19796622_ChIP-Seq_MESCs_Mouse	0.95273806
63	RBPJ_21746931_ChIP-Seq_IB4_Human	0.94179889
64	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.93032678
65	RUNX1_27457419_Chip-Seq_LIVER_Mouse	0.93030051
66	NFYB_21822215_ChIP-Seq_K562_Human	0.92597720
67	CTCF_18555785_Chip-Seq_ESCs_Mouse	0.91898917
68	GATA2_21666600_ChIP-Seq_HMVEC_Human	0.91846948
69	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	0.91335232
70	SUZ12_18555785_Chip-Seq_ESCs_Mouse	0.91325505
71	PU1_27457419_Chip-Seq_LIVER_Mouse	0.90477161
72	OCT1_27270436_Chip-Seq_PROSTATE_Human	0.89711402
73	CBX2_22325352_ChIP-Seq_293T-Rex_Human	0.89354211
74	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	0.89229215
75	P300_18555785_Chip-Seq_ESCs_Mouse	0.88639900
76	RUNX1_27514584_Chip-Seq_MCF-7_Human	0.87420022
77	TCF4_18268006_ChIP-ChIP_LS174T_Human	0.87327978
78	ESRRB_18555785_Chip-Seq_ESCs_Mouse	0.87069569
79	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	0.86865269
80	IRF8_22096565_ChIP-ChIP_GC-B_Human	0.86788423
81	NFIB_24661679_ChIP-Seq_LUNG_Mouse	0.86487208
82	GATA4_25053715_ChIP-Seq_YYC3_Human	0.86344540
83	STAT1_20625510_ChIP-Seq_HELA_Human	0.85624113
84	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.84436425
85	POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.82923987
86	KAP1_22055183_ChIP-Seq_ESCs_Mouse	0.79098095
87	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	0.78948318
88	ESR2_21235772_ChIP-Seq_MCF-7_Human	0.78189997
89	* AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.77244788
90	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	0.75981806
91	Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse	0.73554858
92	* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	0.72266070
93	RARA_24833708_ChIP-Seq_LIVER_Mouse	0.72153407
94	CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse	0.71590739
95	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	0.71383347
96	ZNF263_19887448_ChIP-Seq_K562_Human	0.70348982
97	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	0.69583655
98	* AR_21915096_ChIP-Seq_LNCaP-1F5_Human	0.68568007
99	SALL4_18804426_ChIP-ChIP_XEN_Mouse	0.68499878
100	NR0B1_18358816_ChIP-ChIP_MESCs_Mouse	0.67346324
101	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	0.67067763
102	NRF2_20460467_ChIP-Seq_MEFs_Mouse	0.67067763
103	ESR1_21235772_ChIP-Seq_MCF-7_Human	0.66939791
104	* PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.65593984
105	RAD21_21589869_ChIP-Seq_MESCs_Mouse	0.64368013
106	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	0.63013689
107	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	0.62668690
108	RARB_24833708_ChIP-Seq_LIVER_Mouse	0.61062533
109	STAT3_1855785_ChIP-Seq_MESCs_Mouse	0.59542043
110	CEBPB_22108803_ChIP-Seq_LS180_Human	0.59411116
111	EGR1_19032775_ChIP-ChIP_M12_Human	0.59296181
112	LXR_22292898_ChIP-Seq_THP-1_Human	0.58261554
113	CDX2_20551321_ChIP-Seq_CACO-2_Human	0.56839810
114	AR_20517297_ChIP-Seq_VCAP_Human	0.54540851
115	MYC_19915707_ChIP-ChIP_AK7_Human	0.54188111
116	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	0.53016135
117	FOXA1_25552417_ChIP-Seq_VCAP_Human	0.52688841
118	* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	0.52066192
119	ESET_19884257_ChIP-Seq_ESCs_Mouse	0.51378192
120	STAT1_17558387_ChIP-Seq_HELA_Human	0.49056020
121	CBP_21632823_ChIP-Seq_H3396_Human	0.48634727
122	FOXA1_26743006_Chip-Seq_LNCaP-abl_Human	0.48344131
123	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	0.47993689
124	FOXO3_23340844_ChIP-Seq_DLD1_Human	0.47236007
125	PPARG_20887899_ChIP-Seq_3T3-L1_Mouse	0.45812748
126	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	0.45554483
127	P53_21459846_ChIP-Seq_SAOS-2_Human	0.45082618
128	GATA6_25053715_ChIP-Seq_YYC3_Human	0.44902773
129	TAF2_19829295_ChIP-Seq_ESCs_Human	0.44363555
130	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.44176549
131	FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human	0.43422646
132	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	0.43304535
133	TAF15_26573619_Chip-Seq_HEK293_Human	0.42933263
134	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	0.42811078
135	ESR1_20079471_ChIP-ChIP_T-47D_Human	0.42726102
136	PPAR_26484153_Chip-Seq_NCI-H1993_Human	0.41839894
137	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.41539797
138	GATA1_19941827_ChIP-Seq_MEL_Mouse	0.41246698
139	BCAT_22108803_ChIP-Seq_LS180_Human	0.40823160
140	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.40806405
141	GATA2_19941826_ChIP-Seq_K562_Human	0.40475399
142	ERG_21242973_ChIP-ChIP_JURKAT_Human	0.40367892
143	STAT3_19079543_ChIP-ChIP_MESCs_Mouse	0.40112798
144	GATA1_19941826_ChIP-Seq_K562_Human	0.39646781
145	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.39074333
146	MYC_27129775_Chip-Seq_CORNEA_Mouse	0.36651972
147	CDX2_22108803_ChIP-Seq_LS180_Human	0.36616613
148	NCOR_22424771_ChIP-Seq_293T_Human	0.36019786
149	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.35940927
150	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.35887543
151	SOX2_20726797_ChIP-Seq_SW620_Human	0.35580248
152	LUZP1_20508642_ChIP-Seq_ESCs_Mouse	0.35121856
153	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.34993991

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002139_abnormal_hepatobiliary_system	8.37404546
2	MP0005360_urolithiasis	7.80881423
3	MP0005085_abnormal_gallbladder_physiolo	6.30558953
4	MP0005365_abnormal_bile_salt	6.08357872
5	MP0008875_abnormal_xenobiotic_pharmacok	5.11735188
6	MP0003806_abnormal_nucleotide_metabolis	4.13516004
7	MP0003252_abnormal_bile_duct	3.89228997
8	MP0010329_abnormal_lipoprotein_level	3.41524071
9	MP0003183_abnormal_peptide_metabolism	3.07590279
10	MP0009840_abnormal_foam_cell	3.02396935
11	MP0005332_abnormal_amino_acid	3.02306904
12	MP0003195_calcinosis	2.99657551
13	MP0005083_abnormal_biliary_tract	2.93397476
14	MP0001666_abnormal_nutrient_absorption	2.54678707
15	MP0002132_abnormal_respiratory_system	2.52024825
16	MP0003300_gastrointestinal_ulcer	2.47232870
17	MP0004019_abnormal_vitamin_homeostasis	2.43552171
18	MP0010386_abnormal_urinary_bladder	2.25931046
19	MP0003191_abnormal_cellular_cholesterol	2.25906177
20	MP0003136_yellow_coat_color	2.24528847
21	MP0002138_abnormal_hepatobiliary_system	2.20729028
22	MP0000609_abnormal_liver_physiology	2.08514962
23	MP0002118_abnormal_lipid_homeostasis	2.04664119
24	MP0005319_abnormal_enzyme/_coenzyme	1.84759684
25	MP0003868_abnormal_feces_composition	1.79360957
26	MP0005409_darkened_coat_color	1.70573115
27	MP0001188_hyperpigmentation	1.70402156
28	MP0001764_abnormal_homeostasis	1.66141653
29	MP0005584_abnormal_enzyme/coenzyme_acti	1.60378649
30	MP0009643_abnormal_urine_homeostasis	1.50154919
31	MP0009697_abnormal_copulation	1.43008945
32	MP0005397_hematopoietic_system_phenotyp	1.42868182
33	MP0001545_abnormal_hematopoietic_system	1.42868182
34	MP0005167_abnormal_blood-brain_barrier	1.41271953
35	MP0005451_abnormal_body_composition	1.39411352
36	MP0003186_abnormal_redox_activity	1.34141153
37	MP0005410_abnormal_fertilization	1.29919369
38	MP0003011_delayed_dark_adaptation	1.27696700
39	MP0005310_abnormal_salivary_gland	1.27432025
40	MP0005636_abnormal_mineral_homeostasis	1.15384018
41	MP0000598_abnormal_liver_morphology	1.14562009
42	MP0003656_abnormal_erythrocyte_physiolo	1.12295328
43	MP0004147_increased_porphyrin_level	1.10196061
44	MP0005647_abnormal_sex_gland	1.09927727
45	MP0009764_decreased_sensitivity_to	1.06836852
46	MP0003705_abnormal_hypodermis_morpholog	1.06622959
47	MP0000604_amyloidosis	1.01798968
48	MP0003879_abnormal_hair_cell	0.99017882
49	MP0009763_increased_sensitivity_to	0.96417905
50	MP0003866_abnormal_defecation	0.95715066
51	MP0004233_abnormal_muscle_weight	0.91816412
52	MP0002254_reproductive_system_inflammat	0.90063787
53	MP0008469_abnormal_protein_level	0.89524490
54	MP0003941_abnormal_skin_development	0.88801823
55	MP0009642_abnormal_blood_homeostasis	0.88316451
56	MP0005084_abnormal_gallbladder_morpholo	0.88244065
57	MP0010368_abnormal_lymphatic_system	0.88023227
58	MP0002735_abnormal_chemical_nociception	0.87223768
59	MP0002166_altered_tumor_susceptibility	0.87168008
60	MP0006036_abnormal_mitochondrial_physio	0.86010440
61	MP0002876_abnormal_thyroid_physiology	0.85309173
62	MP0003045_fibrosis	0.84188448
63	MP0001944_abnormal_pancreas_morphology	0.83983649
64	MP0005670_abnormal_white_adipose	0.83778922
65	MP0005408_hypopigmentation	0.83653315
66	MP0001756_abnormal_urination	0.80868070
67	MP0009785_altered_susceptibility_to	0.79136033
68	MP0005376_homeostasis/metabolism_phenot	0.76698007
69	MP0000371_diluted_coat_color	0.76169030
70	MP0002078_abnormal_glucose_homeostasis	0.75601005
71	MP0009765_abnormal_xenobiotic_induced	0.75535674
72	MP0005220_abnormal_exocrine_pancreas	0.74832895
73	MP0002089_abnormal_postnatal_growth/wei	0.73995971
74	MP0001727_abnormal_embryo_implantation	0.72466513
75	MP0002396_abnormal_hematopoietic_system	0.71786917
76	MP0005535_abnormal_body_temperature	0.71608875
77	MP0001661_extended_life_span	0.70622899
78	MP0002971_abnormal_brown_adipose	0.68561564
79	MP0002136_abnormal_kidney_physiology	0.67373758
80	MP0000015_abnormal_ear_pigmentation	0.66388712
81	MP0001485_abnormal_pinna_reflex	0.64256131
82	MP0005334_abnormal_fat_pad	0.64250829
83	MP0003690_abnormal_glial_cell	0.64170533
84	MP0003329_amyloid_beta_deposits	0.63634991
85	MP0004043_abnormal_pH_regulation	0.63286477
86	MP0004130_abnormal_muscle_cell	0.61780436
87	MP0005174_abnormal_tail_pigmentation	0.61632183
88	MP0009053_abnormal_anal_canal	0.61217353
89	MP0005266_abnormal_metabolism	0.61023355
90	MP0005646_abnormal_pituitary_gland	0.59687173
91	MP0004885_abnormal_endolymph	0.58980741
92	MP0001664_abnormal_digestion	0.58867965
93	MP0006035_abnormal_mitochondrial_morpho	0.57157560
94	MP0004808_abnormal_hematopoietic_stem	0.57013525
95	MP0003698_abnormal_male_reproductive	0.56524150
96	MP0002928_abnormal_bile_duct	0.55387050
97	MP0008995_early_reproductive_senescence	0.54333648
98	MP0000639_abnormal_adrenal_gland	0.51449180
99	MP0005395_other_phenotype	0.50821170
100	MP0003638_abnormal_response/metabolism_	0.50365630
101	MP0001929_abnormal_gametogenesis	0.49332227
102	MP0005023_abnormal_wound_healing	0.49324348
103	MP0005448_abnormal_energy_balance	0.48194494
104	MP0005464_abnormal_platelet_physiology	0.46510683
105	MP0003724_increased_susceptibility_to	0.44984021
106	MP0001765_abnormal_ion_homeostasis	0.44876555
107	MP0008874_decreased_physiological_sensi	0.44167642
108	MP0003718_maternal_effect	0.41774283
109	MP0003953_abnormal_hormone_level	0.41274097
110	MP0008873_increased_physiological_sensi	0.41259857
111	MP0005666_abnormal_adipose_tissue	0.41181625
112	MP0002822_catalepsy	0.41055972
113	MP0004782_abnormal_surfactant_physiolog	0.40554750
114	MP0005058_abnormal_lysosome_morphology	0.39672664
115	MP0003075_altered_response_to	0.39448878
116	MP0002168_other_aberrant_phenotype	0.38863816
117	MP0005166_decreased_susceptibility_to	0.38299079
118	MP0002796_impaired_skin_barrier	0.37807929
119	MP0000230_abnormal_systemic_arterial	0.37643254
120	MP0003436_decreased_susceptibility_to	0.36267978
121	MP0009672_abnormal_birth_weight	0.35633418
122	MP0008872_abnormal_physiological_respon	0.35279338
123	MP0004381_abnormal_hair_follicle	0.35093711
124	MP0002837_dystrophic_cardiac_calcinosis	0.34724439
125	MP0005248_abnormal_Harderian_gland	0.34131433
126	MP0000579_abnormal_nail_morphology	0.33600236
127	MP0009384_cardiac_valve_regurgitation	0.32170629
128	MP0006082_CNS_inflammation	0.30609802
129	MP0009115_abnormal_fat_cell	0.30601625
130	MP0002135_abnormal_kidney_morphology	0.30109870
131	MP0000249_abnormal_blood_vessel	0.27839433
132	MP0001845_abnormal_inflammatory_respons	0.27674544
133	MP0002970_abnormal_white_adipose	0.27312453
134	MP0004264_abnormal_extraembryonic_tissu	0.27090513
135	MP0000538_abnormal_urinary_bladder	0.26648191
136	MP0001881_abnormal_mammary_gland	0.25134651
137	MP0001853_heart_inflammation	0.24327914

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of aromatic amino acid family metabolism (HP:0004338)	7.23484561
2	Intrahepatic cholestasis (HP:0001406)	7.15890681
3	Deep venous thrombosis (HP:0002625)	7.02349427
4	Abnormality of monocarboxylic acid metabolism (HP:0010996)	6.44889521
5	Prolonged partial thromboplastin time (HP:0003645)	6.20843443
6	Xanthomatosis (HP:0000991)	6.06505904
7	Hypobetalipoproteinemia (HP:0003563)	5.96996984
8	Complement deficiency (HP:0004431)	5.23590491
9	Hyperlipoproteinemia (HP:0010980)	5.17741862
10	Joint hemorrhage (HP:0005261)	4.63589695
11	Hyperammonemia (HP:0001987)	4.62936435
12	Hyperglycinemia (HP:0002154)	4.53537369
13	Abnormality of glutamine family amino acid metabolism (HP:0010902)	4.48681146
14	Hypolipoproteinemia (HP:0010981)	4.45845527
15	Ketosis (HP:0001946)	4.44360263
16	Severe visual impairment (HP:0001141)	4.39779670
17	Hyperglycinuria (HP:0003108)	4.29942992
18	Epidermoid cyst (HP:0200040)	4.27494275
19	Abnormality of sulfur amino acid metabolism (HP:0004339)	4.27218121
20	Abnormality of the common coagulation pathway (HP:0010990)	4.25754095
21	Abnormality of aspartate family amino acid metabolism (HP:0010899)	4.22195413
22	Abnormality of serine family amino acid metabolism (HP:0010894)	4.18312739
23	Abnormality of glycine metabolism (HP:0010895)	4.18312739
24	Cerebral palsy (HP:0100021)	4.18271086
25	Seborrheic dermatitis (HP:0001051)	4.17785350
26	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	4.07065351
27	Fat malabsorption (HP:0002630)	4.06902673
28	Abnormality of methionine metabolism (HP:0010901)	4.05080980
29	Hypoalphalipoproteinemia (HP:0003233)	3.88709620
30	Hypoglycemic coma (HP:0001325)	3.81010357
31	Abnormality of complement system (HP:0005339)	3.79319152
32	Abnormality of pyrimidine metabolism (HP:0004353)	3.75015485
33	Conjugated hyperbilirubinemia (HP:0002908)	3.61892966
34	Abnormality of the intrinsic pathway (HP:0010989)	3.57718351
35	Reduced antithrombin III activity (HP:0001976)	3.56986568
36	Abnormality of fatty-acid metabolism (HP:0004359)	3.50287257
37	Hypercholesterolemia (HP:0003124)	3.38328218
38	Ketoacidosis (HP:0001993)	3.33217451
39	Abnormality of nucleobase metabolism (HP:0010932)	3.32443894
40	Delayed CNS myelination (HP:0002188)	3.31000075
41	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	3.28602162
42	Hyperbilirubinemia (HP:0002904)	3.26029380
43	Azoospermia (HP:0000027)	3.21570298
44	Gout (HP:0001997)	3.17494540
45	Abnormality of purine metabolism (HP:0004352)	3.11158098
46	Ileus (HP:0002595)	3.09801574
47	Abnormality of serum amino acid levels (HP:0003112)	3.09299540
48	Steatorrhea (HP:0002570)	3.08357977
49	Hepatocellular carcinoma (HP:0001402)	2.96427353
50	Abnormality of the heme biosynthetic pathway (HP:0010472)	2.95319821
51	Metabolic acidosis (HP:0001942)	2.88447584
52	Spontaneous abortion (HP:0005268)	2.87542687
53	Myocardial infarction (HP:0001658)	2.80919756
54	Vascular calcification (HP:0004934)	2.80690233
55	Attenuation of retinal blood vessels (HP:0007843)	2.80615697
56	Abnormality of macular pigmentation (HP:0008002)	2.80435608
57	Hypochromic microcytic anemia (HP:0004840)	2.74429533
58	Nephritis (HP:0000123)	2.74360025
59	Dicarboxylic aciduria (HP:0003215)	2.71707721
60	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.71707721
61	Lethargy (HP:0001254)	2.71437529
62	Systemic lupus erythematosus (HP:0002725)	2.70812408
63	Skin nodule (HP:0200036)	2.61835025
64	Beaking of vertebral bodies (HP:0004568)	2.54144082
65	Spastic diplegia (HP:0001264)	2.49707713
66	Cardiovascular calcification (HP:0011915)	2.48811769
67	Neonatal onset (HP:0003623)	2.46496274
68	Cerebral edema (HP:0002181)	2.45332093
69	Irritability (HP:0000737)	2.44880676
70	Scotoma (HP:0000575)	2.42500016
71	Hypoglycemic seizures (HP:0002173)	2.41616446
72	Male infertility (HP:0003251)	2.40866744
73	Generalized aminoaciduria (HP:0002909)	2.40695260
74	Right ventricular cardiomyopathy (HP:0011663)	2.40380866
75	Joint swelling (HP:0001386)	2.39969579
76	Malnutrition (HP:0004395)	2.38708241
77	Mitral stenosis (HP:0001718)	2.38016321
78	Hypothermia (HP:0002045)	2.36461866
79	Glomerulonephritis (HP:0000099)	2.33861205
80	Acanthocytosis (HP:0001927)	2.33066305
81	Abnormal gallbladder morphology (HP:0012437)	2.32420161
82	Exocrine pancreatic insufficiency (HP:0001738)	2.30163973
83	Abnormal rod and cone electroretinograms (HP:0008323)	2.29178390
84	Recurrent gram-negative bacterial infections (HP:0005420)	2.29117830
85	Abnormal tarsal ossification (HP:0008369)	2.28666455
86	Alkalosis (HP:0001948)	2.27944794
87	Cholelithiasis (HP:0001081)	2.27099337
88	Sensorimotor neuropathy (HP:0007141)	2.26687066
89	Enlarged kidneys (HP:0000105)	2.25716689
90	Late onset (HP:0003584)	2.24990569
91	Proximal tubulopathy (HP:0000114)	2.23418378
92	Vomiting (HP:0002013)	2.23409046
93	Hyperuricemia (HP:0002149)	2.20562555
94	Increased purine levels (HP:0004368)	2.20562555
95	Potter facies (HP:0002009)	2.20212714
96	Facial shape deformation (HP:0011334)	2.20212714
97	Cholecystitis (HP:0001082)	2.18520903
98	Abnormal gallbladder physiology (HP:0012438)	2.18520903
99	Rickets (HP:0002748)	2.16526450
100	Abnormality of carpal bone ossification (HP:0006257)	2.16093772
101	Pancreatitis (HP:0001733)	2.14638830
102	Amyloidosis (HP:0011034)	2.14190025
103	Growth hormone excess (HP:0000845)	2.13095980
104	Esophageal varix (HP:0002040)	2.12083225
105	Arthropathy (HP:0003040)	2.11931010
106	Abnormal spermatogenesis (HP:0008669)	2.11062651
107	Abnormal hemoglobin (HP:0011902)	2.08468937
108	Abnormality of proline metabolism (HP:0010907)	2.07772040
109	Hydroxyprolinuria (HP:0003080)	2.07772040
110	Brushfield spots (HP:0001088)	2.05793024
111	Gingival bleeding (HP:0000225)	2.05380835
112	Menorrhagia (HP:0000132)	2.05231889
113	Opisthotonus (HP:0002179)	2.04908558
114	Thrombophlebitis (HP:0004418)	2.04133969
115	Abnormal enzyme/coenzyme activity (HP:0012379)	2.01503216
116	Chronic hepatic failure (HP:0100626)	1.99291112
117	Glycosuria (HP:0003076)	1.96892241
118	Abnormality of urine glucose concentration (HP:0011016)	1.96892241
119	Increased serum ferritin (HP:0003281)	1.96731808
120	Hypophosphatemic rickets (HP:0004912)	1.95175000
121	Hyperinsulinemic hypoglycemia (HP:0000825)	1.95152565
122	Bony spicule pigmentary retinopathy (HP:0007737)	1.95088217
123	Abnormality of the gallbladder (HP:0005264)	1.93572245
124	Fair hair (HP:0002286)	1.92704547
125	Hemorrhage of the eye (HP:0011885)	1.91002488
126	Abnormality of transition element cation homeostasis (HP:0011030)	1.89710717
127	Neonatal death (HP:0003811)	1.89343915
128	Severe Myopia (HP:0011003)	1.88757209
129	Abnormality of iron homeostasis (HP:0011031)	1.88030142
130	Abnormal cartilage morphology (HP:0002763)	1.87685070
131	Abnormal hand bone ossification (HP:0010660)	1.86141375
132	Pulmonary embolism (HP:0002204)	1.85097265
133	Neoplasm of head and neck (HP:0012288)	1.84584360
134	Esophageal neoplasm (HP:0100751)	1.84584360
135	Reticulocytosis (HP:0001923)	1.83261031
136	Bile duct proliferation (HP:0001408)	1.83104082
137	Abnormal biliary tract physiology (HP:0012439)	1.83104082
138	Poikilocytosis (HP:0004447)	1.82244512
139	Testicular neoplasm (HP:0010788)	1.82139963
140	Tubulointerstitial nephritis (HP:0001970)	1.81816326
141	Renal cortical cysts (HP:0000803)	1.81365964
142	Abnormality of secondary sexual hair (HP:0009888)	1.80182585
143	Abnormality of the axillary hair (HP:0100134)	1.80182585
144	Epiphyseal stippling (HP:0010655)	1.79105020
145	Generalized hypopigmentation of hair (HP:0011358)	1.77842805
146	Neoplasm of the lung (HP:0100526)	1.76552188
147	Submucous cleft hard palate (HP:0000176)	1.75439791
148	Prolonged bleeding time (HP:0003010)	1.75151306
149	Congenital sensorineural hearing impairment (HP:0008527)	1.75141196

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	BCKDK	7.31160683
2	LMTK2	5.59821720
3	FGFR4	4.60502418
4	AKT3	4.49656703
5	ERN1	4.26330649
6	SIK1	4.22177198
7	PIK3CA	3.78554134
8	TAOK3	2.95512510
9	ERBB4	2.92149314
10	INSRR	2.85771369
11	TNK2	2.72612556
12	MST1R	2.21836382
13	MAP2K4	2.20006168
14	ILK	2.03499503
15	PKN2	1.93152556
16	MYLK	1.93136964
17	MAPK11	1.91444579
18	STK39	1.76037530
19	PIK3CG	1.74616101
20	TRIB3	1.68015307
21	FLT3	1.65385372
22	LATS1	1.61627083
23	DAPK2	1.57604844
24	TYK2	1.57263884
25	FER	1.48271225
26	ABL2	1.46553097
27	PTK6	1.46370345
28	CDK12	1.44932270
29	PIM2	1.41744237
30	STK38L	1.40824490
31	NEK9	1.33367878
32	NTRK3	1.32081498
33	FRK	1.31689523
34	MAP3K12	1.31161992
35	FGFR2	1.29604530
36	WNK3	1.28640265
37	MAP3K7	1.26414243
38	PINK1	1.25937079
39	JAK2	1.19463561
40	KDR	1.17259880
41	GRK6	1.17042000
42	MARK2	1.14152751
43	WNK4	1.13537045
44	DMPK	1.13258601
45	EIF2AK1	1.12560325
46	PRKAA2	1.10848454
47	BRSK2	1.08275093
48	NUAK1	1.03649118
49	MAP2K3	1.00827264
50	MAP4K2	1.00217529
51	ERBB2	0.99659719
52	RIPK4	0.99205843
53	MAP3K14	0.98465294
54	TNIK	0.98003276
55	TBK1	0.96658619
56	EPHB1	0.96648513
57	PRKD2	0.95883904
58	SGK1	0.94578013
59	PRKCZ	0.92604480
60	JAK1	0.92360814
61	BMPR1B	0.92300429
62	BRD4	0.92086834
63	EIF2AK3	0.90470256
64	MAPK4	0.89929121
65	TIE1	0.89627916
66	NME1	0.89180314
67	PLK4	0.89028704
68	MAPK15	0.88277769
69	CDK9	0.87356423
70	MAP3K3	0.86848461
71	HIPK2	0.85963647
72	WNK1	0.85548718
73	NEK6	0.84868417
74	MAP3K10	0.84734215
75	MET	0.84431676
76	OXSR1	0.84291638
77	SGK3	0.80596078
78	DYRK1B	0.79826814
79	MAPK12	0.77561835
80	GSK3A	0.74946980
81	PRKACG	0.74549665
82	MAP3K11	0.73664724
83	TESK1	0.71275230
84	PRKAA1	0.70373525
85	CDK6	0.69006169
86	SGK494	0.68734730
87	SGK223	0.68734730
88	PRKG2	0.68530898
89	EPHA3	0.68291436
90	CAMK2G	0.67586787
91	IRAK3	0.67270448
92	SGK2	0.66001019
93	BTK	0.65883003
94	TGFBR2	0.64338916
95	CSK	0.63895400
96	NLK	0.63871273
97	MAP2K6	0.63598252
98	PTK2	0.62876409
99	STK24	0.62787571
100	JAK3	0.61706299
101	TAOK1	0.61604476
102	PRKD1	0.60399100
103	RIPK1	0.59634326
104	RPS6KB2	0.58441223
105	TRPM7	0.57938483
106	ERBB3	0.57367148
107	PDK3	0.57185487
108	PDK4	0.57185487
109	RPS6KA4	0.56938496
110	PDPK1	0.56537690
111	CAMK1D	0.55845877
112	FGFR3	0.52917095
113	TEC	0.52683956
114	CAMK1G	0.51660813
115	YES1	0.50271399
116	MARK3	0.50233004
117	MAPK3	0.50103232
118	MAPK7	0.49884580
119	PRKCQ	0.48216985
120	IKBKE	0.47936304
121	EPHA4	0.47798733
122	PRKG1	0.47778241
123	RPS6KA5	0.46902546
124	CSF1R	0.45976500
125	LRRK2	0.44197680
126	CSNK1G1	0.43813645
127	IGF1R	0.42406588
128	RAF1	0.41897118
129	MAPK10	0.40691732
130	PKN1	0.40109228
131	GRK1	0.39536453
132	STK11	0.39529881
133	PRKACA	0.39209915
134	ADRBK2	0.38827266
135	RPS6KA3	0.38447014
136	MAP2K1	0.38099531
137	PRKCG	0.37838791
138	MAP3K13	0.36457375
139	MAP3K5	0.36396384
140	MINK1	0.35694956
141	TAOK2	0.35288676
142	ICK	0.34762227
143	CSNK1E	0.34697151
144	PRKCE	0.34235405
145	MTOR	0.34200246
146	PDK1	0.34092578
147	RET	0.33479523
148	EGFR	0.32516141
149	CAMK4	0.31004718
150	NEK1	0.30523578
151	IRAK2	0.30395924
152	CDK4	0.29896641
153	IRAK1	0.29860277
154	STK38	0.29289692
155	MAP3K6	0.28211073
156	PRKCA	0.27338153
157	PAK3	0.25354335
158	MAP3K1	0.24041395
159	PBK	0.23102179
160	PDK2	0.21950542

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Primary bile acid biosynthesis_Homo sapiens_hsa00120	4.43162938
2	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	3.42119324
3	Nitrogen metabolism_Homo sapiens_hsa00910	3.41767298
4	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	3.29878011
5	Arginine biosynthesis_Homo sapiens_hsa00220	2.97460766
6	Tryptophan metabolism_Homo sapiens_hsa00380	2.73893223
7	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	2.71978734
8	Complement and coagulation cascades_Homo sapiens_hsa04610	2.63251778
9	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	2.61216854
10	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	2.54792555
11	Fatty acid degradation_Homo sapiens_hsa00071	2.50255809
12	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.47569653
13	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	2.35960444
14	Peroxisome_Homo sapiens_hsa04146	2.16985362
15	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	2.15612147
16	* Butanoate metabolism_Homo sapiens_hsa00650	2.09437257
17	Propanoate metabolism_Homo sapiens_hsa00640	2.03284689
18	Chemical carcinogenesis_Homo sapiens_hsa05204	1.94695430
19	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.92435815
20	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.89700875
21	Histidine metabolism_Homo sapiens_hsa00340	1.87690813
22	PPAR signaling pathway_Homo sapiens_hsa03320	1.83393232
23	Fatty acid metabolism_Homo sapiens_hsa01212	1.80382502
24	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.75609348
25	beta-Alanine metabolism_Homo sapiens_hsa00410	1.75431312
26	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.73610313
27	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.69492297
28	Retinol metabolism_Homo sapiens_hsa00830	1.67666533
29	Caffeine metabolism_Homo sapiens_hsa00232	1.66389407
30	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.65674699
31	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.65076858
32	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.63892973
33	Selenocompound metabolism_Homo sapiens_hsa00450	1.58904550
34	Bile secretion_Homo sapiens_hsa04976	1.54137360
35	Phenylalanine metabolism_Homo sapiens_hsa00360	1.54045215
36	Pyruvate metabolism_Homo sapiens_hsa00620	1.45528739
37	Sulfur metabolism_Homo sapiens_hsa00920	1.41879656
38	Tyrosine metabolism_Homo sapiens_hsa00350	1.40921542
39	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.39136032
40	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.30513027
41	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.28693068
42	Fatty acid elongation_Homo sapiens_hsa00062	1.27772315
43	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.25499372
44	Folate biosynthesis_Homo sapiens_hsa00790	1.21995197
45	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.19548479
46	Carbon metabolism_Homo sapiens_hsa01200	1.17409846
47	Steroid biosynthesis_Homo sapiens_hsa00100	1.16362044
48	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.15993048
49	ABC transporters_Homo sapiens_hsa02010	1.15220661
50	Fat digestion and absorption_Homo sapiens_hsa04975	1.06837650
51	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.03017271
52	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.01602421
53	Arginine and proline metabolism_Homo sapiens_hsa00330	1.00686426
54	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.97545537
55	Other glycan degradation_Homo sapiens_hsa00511	0.95501078
56	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.94865513
57	Sulfur relay system_Homo sapiens_hsa04122	0.92972657
58	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.91857366
59	Lysine degradation_Homo sapiens_hsa00310	0.85876098
60	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.84821284
61	Glutathione metabolism_Homo sapiens_hsa00480	0.78657582
62	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.74659504
63	One carbon pool by folate_Homo sapiens_hsa00670	0.71050988
64	Pancreatic secretion_Homo sapiens_hsa04972	0.70084909
65	Glycerolipid metabolism_Homo sapiens_hsa00561	0.68545521
66	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.62130235
67	Circadian rhythm_Homo sapiens_hsa04710	0.61827220
68	Pentose phosphate pathway_Homo sapiens_hsa00030	0.57633179
69	* Metabolic pathways_Homo sapiens_hsa01100	0.46713969
70	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.45044949
71	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.37931534
72	Prion diseases_Homo sapiens_hsa05020	0.33000899
73	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.28247281
74	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.25210648
75	Olfactory transduction_Homo sapiens_hsa04740	0.25208062
76	Galactose metabolism_Homo sapiens_hsa00052	0.24086955
77	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.22559547
78	Insulin resistance_Homo sapiens_hsa04931	0.21490744
79	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.19879553
80	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.19549099
81	Linoleic acid metabolism_Homo sapiens_hsa00591	0.16734693
82	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.15113101
83	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.11831068
84	Pertussis_Homo sapiens_hsa05133	0.11446488
85	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.10180348
86	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.10024875
87	Serotonergic synapse_Homo sapiens_hsa04726	0.09759456
88	Glucagon signaling pathway_Homo sapiens_hsa04922	0.08139330
89	Renin secretion_Homo sapiens_hsa04924	0.05113492
90	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.04754216
91	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.01300679
92	Sphingolipid metabolism_Homo sapiens_hsa00600	0.01254983
93	Type II diabetes mellitus_Homo sapiens_hsa04930	0.01087233
94	AMPK signaling pathway_Homo sapiens_hsa04152	0.00931771
95	Ether lipid metabolism_Homo sapiens_hsa00565	0.00291499
96	Lysosome_Homo sapiens_hsa04142	-0.2290355
97	Bladder cancer_Homo sapiens_hsa05219	-0.2269453
98	Mineral absorption_Homo sapiens_hsa04978	-0.2143927
99	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	-0.2082974
100	Protein digestion and absorption_Homo sapiens_hsa04974	-0.2026971
101	African trypanosomiasis_Homo sapiens_hsa05143	-0.1905333
102	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	-0.1900912
103	Systemic lupus erythematosus_Homo sapiens_hsa05322	-0.1742823
104	Central carbon metabolism in cancer_Homo sapiens_hsa05230	-0.1723326
105	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	-0.1721445
106	Hepatitis C_Homo sapiens_hsa05160	-0.1692843
107	Thyroid hormone synthesis_Homo sapiens_hsa04918	-0.1413763
108	Renin-angiotensin system_Homo sapiens_hsa04614	-0.1347702
109	Regulation of autophagy_Homo sapiens_hsa04140	-0.1293235
110	Insulin signaling pathway_Homo sapiens_hsa04910	-0.1207004
111	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	-0.1197103
112	Arachidonic acid metabolism_Homo sapiens_hsa00590	-0.1196080
113	Glycosaminoglycan degradation_Homo sapiens_hsa00531	-0.0975960
114	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	-0.0946460
115	Ovarian steroidogenesis_Homo sapiens_hsa04913	-0.0902899
116	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	-0.0333933
117	Leukocyte transendothelial migration_Homo sapiens_hsa04670	-0.0188395
118	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	-0.0178279
119	Tight junction_Homo sapiens_hsa04530	-0.0152008

ACSM1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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