ACSM2A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1drug catabolic process (GO:0042737)9.72536182
2regulation of fibrinolysis (GO:0051917)7.90987279
3epoxygenase P450 pathway (GO:0019373)7.79031517
4negative regulation of fibrinolysis (GO:0051918)7.74150682
5omega-hydroxylase P450 pathway (GO:0097267)7.67490980
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.58128766
7L-phenylalanine catabolic process (GO:0006559)7.58128766
8glyoxylate metabolic process (GO:0046487)7.56354459
9L-phenylalanine metabolic process (GO:0006558)6.80577337
10erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.80577337
11regulation of protein activation cascade (GO:2000257)6.65082715
12complement activation, alternative pathway (GO:0006957)6.53720957
13cellular glucuronidation (GO:0052695)6.51354181
14oxidative demethylation (GO:0070989)6.46793189
15fibrinolysis (GO:0042730)6.41270884
16aromatic amino acid family catabolic process (GO:0009074)6.38217324
17regulation of complement activation (GO:0030449)6.27404635
18uronic acid metabolic process (GO:0006063)6.20184241
19glucuronate metabolic process (GO:0019585)6.20184241
20drug metabolic process (GO:0017144)6.06033407
21bile acid biosynthetic process (GO:0006699)5.91478071
22negative regulation of sterol transport (GO:0032372)5.89986423
23negative regulation of cholesterol transport (GO:0032375)5.89986423
24urea metabolic process (GO:0019627)5.85496879
25protein carboxylation (GO:0018214)5.74802351
26peptidyl-glutamic acid carboxylation (GO:0017187)5.74802351
27ethanol oxidation (GO:0006069)5.66449242
28blood coagulation, intrinsic pathway (GO:0007597)5.51724290
29serine family amino acid catabolic process (GO:0009071)5.46211983
30indole-containing compound catabolic process (GO:0042436)5.31629375
31indolalkylamine catabolic process (GO:0046218)5.31629375
32tryptophan catabolic process (GO:0006569)5.31629375
33nitrogen cycle metabolic process (GO:0071941)5.31214282
34phenylpropanoid metabolic process (GO:0009698)5.31123392
35regulation of triglyceride catabolic process (GO:0010896)5.30288608
36bile acid metabolic process (GO:0008206)5.29738595
37S-adenosylmethionine metabolic process (GO:0046500)5.20586804
38regulation of plasminogen activation (GO:0010755)5.03575557
39amino-acid betaine metabolic process (GO:0006577)4.87602436
40alkaloid metabolic process (GO:0009820)4.84825686
41glycine metabolic process (GO:0006544)4.81737098
42bile acid and bile salt transport (GO:0015721)4.79649409
43triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.69788801
44urea cycle (GO:0000050)4.69326905
45negative regulation of blood coagulation (GO:0030195)4.67586629
46negative regulation of hemostasis (GO:1900047)4.67586629
47tyrosine metabolic process (GO:0006570)4.52816472
48ethanol metabolic process (GO:0006067)4.50144794
49tryptophan metabolic process (GO:0006568)4.42296375
50phospholipid efflux (GO:0033700)4.40038437
51aromatic amino acid family metabolic process (GO:0009072)4.35269284
52protein activation cascade (GO:0072376)4.33298164
53flavonoid metabolic process (GO:0009812)4.29547440
54negative regulation of coagulation (GO:0050819)4.25354724
55intestinal cholesterol absorption (GO:0030299)4.22418583
56high-density lipoprotein particle remodeling (GO:0034375)4.20645121
57negative regulation of protein activation cascade (GO:2000258)4.16352929
58* acylglycerol homeostasis (GO:0055090)4.15781748
59* triglyceride homeostasis (GO:0070328)4.15781748
60negative regulation of wound healing (GO:0061045)4.12258491
61imidazole-containing compound metabolic process (GO:0052803)4.12243510
62arginine metabolic process (GO:0006525)4.08162626
63heme transport (GO:0015886)4.06230484
64fat-soluble vitamin biosynthetic process (GO:0042362)4.05511462
65amino acid salvage (GO:0043102)4.05050658
66L-methionine salvage (GO:0071267)4.05050658
67L-methionine biosynthetic process (GO:0071265)4.05050658
68cellular ketone body metabolic process (GO:0046950)4.04692001
69plasma lipoprotein particle remodeling (GO:0034369)4.03188999
70protein-lipid complex remodeling (GO:0034368)4.03188999
71macromolecular complex remodeling (GO:0034367)4.03188999
72cholesterol efflux (GO:0033344)4.01696818
73positive regulation of hemostasis (GO:1900048)4.00884199
74positive regulation of blood coagulation (GO:0030194)4.00884199
75negative regulation of lipase activity (GO:0060192)3.98486764
76alpha-amino acid catabolic process (GO:1901606)3.92613027
77regulation of humoral immune response (GO:0002920)3.92584240
78complement activation, classical pathway (GO:0006958)3.90032004
79complement activation (GO:0006956)3.86263470
80serine family amino acid metabolic process (GO:0009069)3.83956261
81acute-phase response (GO:0006953)3.83836074
82reverse cholesterol transport (GO:0043691)3.82935844
83positive regulation of coagulation (GO:0050820)3.70015193
84sodium-independent organic anion transport (GO:0043252)3.67961812
85xenobiotic metabolic process (GO:0006805)3.65828170
86drug transmembrane transport (GO:0006855)3.62236696
87kynurenine metabolic process (GO:0070189)3.61071880
88daunorubicin metabolic process (GO:0044597)3.58658906
89polyketide metabolic process (GO:0030638)3.58658906
90doxorubicin metabolic process (GO:0044598)3.58658906
91positive regulation of lipoprotein lipase activity (GO:0051006)3.58057143
92positive regulation of triglyceride lipase activity (GO:0061365)3.58057143
93response to mercury ion (GO:0046689)3.57932331
94ketone body metabolic process (GO:1902224)3.57031339
95indolalkylamine metabolic process (GO:0006586)3.51975298
96negative regulation of complement activation (GO:0045916)3.49488624
97cellular biogenic amine catabolic process (GO:0042402)3.47235668
98amine catabolic process (GO:0009310)3.47235668
99regulation of cholesterol esterification (GO:0010872)3.45443711
100exogenous drug catabolic process (GO:0042738)10.4208896

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.41755179
2EGR1_23403033_ChIP-Seq_LIVER_Mouse5.56796115
3RXR_22158963_ChIP-Seq_LIVER_Mouse4.77022343
4LXR_22158963_ChIP-Seq_LIVER_Mouse4.26383593
5PPARA_22158963_ChIP-Seq_LIVER_Mouse4.00078091
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.52331026
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.30445185
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.17766464
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.98536398
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.22364863
11GBX2_23144817_ChIP-Seq_PC3_Human2.16206882
12IGF1R_20145208_ChIP-Seq_DFB_Human2.10888898
13PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.09008727
14POU3F2_20337985_ChIP-ChIP_501MEL_Human1.91651870
15FOXA2_19822575_ChIP-Seq_HepG2_Human1.82976180
16* HNF4A_19822575_ChIP-Seq_HepG2_Human1.77337268
17PIAS1_25552417_ChIP-Seq_VCAP_Human1.71372599
18GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.61199843
19AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.59400248
20BCAT_22108803_ChIP-Seq_LS180_Human1.58651095
21VDR_22108803_ChIP-Seq_LS180_Human1.58389285
22BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.53701488
23ER_23166858_ChIP-Seq_MCF-7_Human1.53545591
24ESR1_20079471_ChIP-ChIP_T-47D_Human1.53412852
25HTT_18923047_ChIP-ChIP_STHdh_Human1.52001663
26ZFP57_27257070_Chip-Seq_ESCs_Mouse1.49610305
27HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.48608125
28TAF15_26573619_Chip-Seq_HEK293_Human1.47726733
29STAT3_23295773_ChIP-Seq_U87_Human1.41245502
30TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.40933877
31CTBP1_25329375_ChIP-Seq_LNCAP_Human1.34361281
32NFE2_27457419_Chip-Seq_LIVER_Mouse1.33781746
33ZNF274_21170338_ChIP-Seq_K562_Hela1.32605292
34EZH2_27294783_Chip-Seq_NPCs_Mouse1.31710744
35CTBP2_25329375_ChIP-Seq_LNCAP_Human1.30530986
36AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.26729837
37UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.24701705
38P300_19829295_ChIP-Seq_ESCs_Human1.23442505
39IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.22836289
40CBP_20019798_ChIP-Seq_JUKART_Human1.22836289
41SUZ12_27294783_Chip-Seq_NPCs_Mouse1.22613733
42PCGF2_27294783_Chip-Seq_NPCs_Mouse1.22301562
43IRF1_19129219_ChIP-ChIP_H3396_Human1.21353520
44CDX2_19796622_ChIP-Seq_MESCs_Mouse1.20305910
45FLI1_27457419_Chip-Seq_LIVER_Mouse1.20044476
46TCF4_23295773_ChIP-Seq_U87_Human1.19491557
47* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.17900596
48CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.14812682
49TCF4_22108803_ChIP-Seq_LS180_Human1.13567332
50NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.13216468
51SMAD4_21799915_ChIP-Seq_A2780_Human1.13196928
52E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.11799387
53AR_20517297_ChIP-Seq_VCAP_Human1.11732253
54SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.11631285
55CDX2_22108803_ChIP-Seq_LS180_Human1.11626677
56PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.10968371
57TP53_18474530_ChIP-ChIP_U2OS_Human1.10402178
58SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09071706
59CRX_20693478_ChIP-Seq_RETINA_Mouse1.07698992
60FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.06764645
61TP53_16413492_ChIP-PET_HCT116_Human1.06161829
62NANOG_19829295_ChIP-Seq_ESCs_Human1.05766087
63SOX2_19829295_ChIP-Seq_ESCs_Human1.05766087
64GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.04303519
65PCGF2_27294783_Chip-Seq_ESCs_Mouse1.03839105
66AR_25329375_ChIP-Seq_VCAP_Human1.03614821
67PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.03287110
68FOXA1_21572438_ChIP-Seq_LNCaP_Human1.02628838
69CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.01596833
70IRF8_22096565_ChIP-ChIP_GC-B_Human1.01009545
71NR3C1_21868756_ChIP-Seq_MCF10A_Human1.00841637
72STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.00829869
73SMAD4_21741376_ChIP-Seq_EPCs_Human1.00360565
74EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.00212880
75SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.99071010
76ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.98694306
77ETV2_25802403_ChIP-Seq_MESCs_Mouse0.98686248
78NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.98106283
79NRF2_20460467_ChIP-Seq_MEFs_Mouse0.98106283
80CBP_21632823_ChIP-Seq_H3396_Human0.98005567
81RUNX2_22187159_ChIP-Seq_PCA_Human0.97318982
82OCT4_21477851_ChIP-Seq_ESCs_Mouse0.96672927
83SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.95801950
84EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.95748178
85IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.95047874
86HNFA_21074721_ChIP-Seq_CACO-2_Human0.94927290
87PHF8_20622853_ChIP-Seq_HELA_Human0.94802857
88NFYA_21822215_ChIP-Seq_K562_Human0.94701824
89MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.94533801
90FOXA1_25329375_ChIP-Seq_VCAP_Human0.92621895
91FOXA1_27270436_Chip-Seq_PROSTATE_Human0.92621895
92CEBPB_22108803_ChIP-Seq_LS180_Human0.91970008
93GATA4_25053715_ChIP-Seq_YYC3_Human0.91898567
94FOXA1_25552417_ChIP-Seq_VCAP_Human0.89821476
95NANOG_18555785_Chip-Seq_ESCs_Mouse0.88720831
96SMAD3_21741376_ChIP-Seq_EPCs_Human0.88515234
97AUTS2_25519132_ChIP-Seq_293T-REX_Human0.88333192
98NCOR_22424771_ChIP-Seq_293T_Human0.88238059
99FOXH1_21741376_ChIP-Seq_EPCs_Human0.88079154
100CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.86970634

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system9.62967077
2MP0005085_abnormal_gallbladder_physiolo6.19262213
3MP0003195_calcinosis6.15838216
4MP0005365_abnormal_bile_salt5.75642606
5MP0005360_urolithiasis5.51005030
6MP0008875_abnormal_xenobiotic_pharmacok5.47614154
7MP0002138_abnormal_hepatobiliary_system4.51992337
8MP0003252_abnormal_bile_duct4.38841288
9MP0001666_abnormal_nutrient_absorption3.18527619
10MP0003868_abnormal_feces_composition2.99526865
11MP0010329_abnormal_lipoprotein_level2.85788218
12MP0005332_abnormal_amino_acid2.42120668
13MP0009697_abnormal_copulation2.35102371
14MP0002876_abnormal_thyroid_physiology2.18822140
15MP0009840_abnormal_foam_cell1.94451060
16MP0003806_abnormal_nucleotide_metabolis1.85660553
17MP0002118_abnormal_lipid_homeostasis1.67483743
18MP0000609_abnormal_liver_physiology1.66325838
19MP0001764_abnormal_homeostasis1.64532166
20MP0010368_abnormal_lymphatic_system1.37404450
21MP0003191_abnormal_cellular_cholesterol1.28900830
22MP0005408_hypopigmentation1.16806390
23MP0005670_abnormal_white_adipose1.13233773
24MP0004019_abnormal_vitamin_homeostasis1.11681537
25MP0005319_abnormal_enzyme/_coenzyme1.08138969
26MP0009053_abnormal_anal_canal1.04513893
27MP0008872_abnormal_physiological_respon1.02062657
28MP0009643_abnormal_urine_homeostasis1.01842037
29MP0001661_extended_life_span1.01229382
30MP0003879_abnormal_hair_cell0.98735566
31MP0003011_delayed_dark_adaptation0.97638367
32MP0002168_other_aberrant_phenotype0.92496342
33MP0005584_abnormal_enzyme/coenzyme_acti0.91898998
34MP0005395_other_phenotype0.90825090
35MP0000598_abnormal_liver_morphology0.88443573
36MP0003656_abnormal_erythrocyte_physiolo0.87958663
37MP0009764_decreased_sensitivity_to0.85662185
38MP0005376_homeostasis/metabolism_phenot0.83019683
39MP0009642_abnormal_blood_homeostasis0.80732372
40MP0005636_abnormal_mineral_homeostasis0.77376687
41MP0005187_abnormal_penis_morphology0.75766311
42MP0002971_abnormal_brown_adipose0.74265611
43MP0005266_abnormal_metabolism0.72092349
44MP0004043_abnormal_pH_regulation0.71179521
45MP0005551_abnormal_eye_electrophysiolog0.69837807
46MP0002132_abnormal_respiratory_system0.69139114
47MP0002928_abnormal_bile_duct0.66090275
48MP0005535_abnormal_body_temperature0.65989630
49MP0008469_abnormal_protein_level0.65230644
50MP0002078_abnormal_glucose_homeostasis0.64261552
51MP0003186_abnormal_redox_activity0.63661671
52MP0003638_abnormal_response/metabolism_0.63073916
53MP0009763_increased_sensitivity_to0.62750693
54MP0005646_abnormal_pituitary_gland0.60280713
55MP0003718_maternal_effect0.59524113
56MP0003690_abnormal_glial_cell0.59094920
57MP0003646_muscle_fatigue0.58268944
58MP0004142_abnormal_muscle_tone0.58036151
59MP0005084_abnormal_gallbladder_morpholo0.56512954
60MP0002282_abnormal_trachea_morphology0.56383145
61MP0003878_abnormal_ear_physiology0.54692204
62MP0005377_hearing/vestibular/ear_phenot0.54692204
63MP0001501_abnormal_sleep_pattern0.51968856
64MP0005448_abnormal_energy_balance0.51614031
65MP0001986_abnormal_taste_sensitivity0.50252278
66MP0005334_abnormal_fat_pad0.50147560
67MP0000604_amyloidosis0.48979366
68MP0001915_intracranial_hemorrhage0.48528542
69MP0005647_abnormal_sex_gland0.48170865
70MP0010386_abnormal_urinary_bladder0.47111809
71MP0001756_abnormal_urination0.46468456
72MP0005220_abnormal_exocrine_pancreas0.44833295
73MP0004130_abnormal_muscle_cell0.43614294
74MP0005451_abnormal_body_composition0.41932771
75MP0006036_abnormal_mitochondrial_physio0.41442620
76MP0002909_abnormal_adrenal_gland0.39791336
77MP0005464_abnormal_platelet_physiology0.38968679
78MP0003953_abnormal_hormone_level0.38843443
79MP0008874_decreased_physiological_sensi0.37343594
80MP0001984_abnormal_olfaction0.37145587
81MP0002136_abnormal_kidney_physiology0.35840875
82MP0004883_abnormal_blood_vessel0.35403867
83MP0000639_abnormal_adrenal_gland0.35382656
84MP0009745_abnormal_behavioral_response0.34894096
85MP0003633_abnormal_nervous_system0.34732431
86MP0005386_behavior/neurological_phenoty0.33226584
87MP0004924_abnormal_behavior0.33226584
88MP0003632_abnormal_nervous_system0.31854625
89MP0000249_abnormal_blood_vessel0.30277005
90MP0000371_diluted_coat_color0.29985349
91MP0009115_abnormal_fat_cell0.29755601
92MP0003631_nervous_system_phenotype0.29540801
93MP0003959_abnormal_lean_body0.29386576
94MP0002249_abnormal_larynx_morphology0.28258937
95MP0002102_abnormal_ear_morphology0.28203484
96MP0005164_abnormal_response_to0.26811139
97MP0001944_abnormal_pancreas_morphology0.25300722
98MP0000569_abnormal_digit_pigmentation0.21475257
99MP0003045_fibrosis0.21196287
100MP0009785_altered_susceptibility_to0.21097287

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of monocarboxylic acid metabolism (HP:0010996)9.78527451
2Deep venous thrombosis (HP:0002625)9.12378892
3Prolonged partial thromboplastin time (HP:0003645)8.76613869
4Complement deficiency (HP:0004431)7.97815226
5Abnormality of aromatic amino acid family metabolism (HP:0004338)7.88927206
6Hypobetalipoproteinemia (HP:0003563)7.65765877
7Conjugated hyperbilirubinemia (HP:0002908)6.60291653
8Abnormality of complement system (HP:0005339)6.24496610
9Joint hemorrhage (HP:0005261)5.91646294
10Hyperlipoproteinemia (HP:0010980)5.63802729
11Systemic lupus erythematosus (HP:0002725)5.38866179
12Intrahepatic cholestasis (HP:0001406)5.01716884
13Xanthomatosis (HP:0000991)4.67714785
14Abnormality of pyrimidine metabolism (HP:0004353)4.41518452
15Glomerulonephritis (HP:0000099)4.40065352
16Abnormality of the common coagulation pathway (HP:0010990)4.33454758
17Hypolipoproteinemia (HP:0010981)4.27650663
18Spontaneous abortion (HP:0005268)4.05032339
19Abnormality of the intrinsic pathway (HP:0010989)3.97401783
20Hyperglycinemia (HP:0002154)3.89389627
21Abnormality of glutamine family amino acid metabolism (HP:0010902)3.79509856
22Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.78364919
23Fat malabsorption (HP:0002630)3.55222224
24Nephritis (HP:0000123)3.49545067
25Abnormality of glycine metabolism (HP:0010895)3.43820435
26Abnormality of serine family amino acid metabolism (HP:0010894)3.43820435
27Recurrent gram-negative bacterial infections (HP:0005420)3.36842230
28Hyperglycinuria (HP:0003108)3.35287063
29Generalized aminoaciduria (HP:0002909)3.28285009
30Rickets (HP:0002748)3.18676632
31Fair hair (HP:0002286)3.18044988
32Hyperammonemia (HP:0001987)3.06254118
33Abnormality of methionine metabolism (HP:0010901)3.04641037
34Delayed CNS myelination (HP:0002188)3.03828565
35Vascular calcification (HP:0004934)3.02540337
36Steatorrhea (HP:0002570)3.02320166
37Mitral stenosis (HP:0001718)2.99398885
38Abnormality of serum amino acid levels (HP:0003112)2.85342419
39Epidermoid cyst (HP:0200040)2.77235407
40Gingival bleeding (HP:0000225)2.75091530
41Hypercholesterolemia (HP:0003124)2.71429113
42Osteomalacia (HP:0002749)2.66866543
43Hypoalphalipoproteinemia (HP:0003233)2.64713400
44Cardiovascular calcification (HP:0011915)2.63914654
45Abnormality of aspartate family amino acid metabolism (HP:0010899)2.60700747
46Hemorrhage of the eye (HP:0011885)2.52647825
47Abnormality of vitamin metabolism (HP:0100508)2.49744928
48Ketosis (HP:0001946)2.49126682
49Abnormality of nucleobase metabolism (HP:0010932)2.46136371
50Menorrhagia (HP:0000132)2.38067674
51Glycosuria (HP:0003076)2.35931285
52Abnormality of urine glucose concentration (HP:0011016)2.35931285
53Thrombophlebitis (HP:0004418)2.31344070
54Arthropathy (HP:0003040)2.31081609
55Abnormal biliary tract physiology (HP:0012439)2.29390599
56Bile duct proliferation (HP:0001408)2.29390599
57Hyperbilirubinemia (HP:0002904)2.28569999
58Hypochromic microcytic anemia (HP:0004840)2.27406532
59Metabolic acidosis (HP:0001942)2.26846264
60Hydroxyprolinuria (HP:0003080)2.26074492
61Abnormality of proline metabolism (HP:0010907)2.26074492
62Generalized hypopigmentation of hair (HP:0011358)2.25710023
63Pulmonary embolism (HP:0002204)2.25410622
64Hypophosphatemic rickets (HP:0004912)2.19985595
65Abnormality of sulfur amino acid metabolism (HP:0004339)2.19598246
66Purpura (HP:0000979)2.19290018
67Bifid scrotum (HP:0000048)2.19145597
68Enlarged kidneys (HP:0000105)2.15007118
69Hyperphosphaturia (HP:0003109)2.13155656
70Reduced antithrombin III activity (HP:0001976)2.09720618
71Hepatocellular carcinoma (HP:0001402)2.05600695
72Proximal tubulopathy (HP:0000114)2.03138772
73Poikilocytosis (HP:0004447)2.01514560
74Neonatal hypoglycemia (HP:0001998)1.87277345
75Alkalosis (HP:0001948)1.85675010
76Irritability (HP:0000737)1.85210452
77Ketoacidosis (HP:0001993)1.78836057
78Increased mean platelet volume (HP:0011877)1.72940094
79Hypochromic anemia (HP:0001931)1.72739284
80Gangrene (HP:0100758)1.72219885
81Lethargy (HP:0001254)1.71388704
82Joint swelling (HP:0001386)1.71013631
83Potter facies (HP:0002009)1.69613551
84Facial shape deformation (HP:0011334)1.69613551
85Blue irides (HP:0000635)1.69384344
86Abnormality of transition element cation homeostasis (HP:0011030)1.61620382
87Abnormal urine phosphate concentration (HP:0012599)1.61076560
88Hyperventilation (HP:0002883)1.60958980
89Cerebral palsy (HP:0100021)1.58229219
90Myocardial infarction (HP:0001658)1.57268434
91Abnormality of purine metabolism (HP:0004352)1.56586251
92Hypoglycemic coma (HP:0001325)1.55979741
93Decreased central vision (HP:0007663)1.52146378
94Submucous cleft hard palate (HP:0000176)1.52061651
95Retinal atrophy (HP:0001105)1.50194684
96Renal cortical cysts (HP:0000803)1.49426119
97Abnormal gallbladder morphology (HP:0012437)1.48816868
98Abnormal platelet volume (HP:0011876)1.48715589
99Abnormality of iron homeostasis (HP:0011031)1.48655686
100Pancreatitis (HP:0001733)1.48096898

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK8.32515352
2PIK3CG3.08105386
3WNK32.93781099
4NTRK32.69502731
5ACVR1B2.57048977
6PINK12.41312698
7INSRR2.23543352
8BMPR1B2.06990621
9PIK3CA2.01567555
10TAOK32.01398530
11ADRBK21.98576832
12GRK11.83805098
13MAP4K21.79486700
14CASK1.73311231
15STK38L1.69128970
16PRKAA21.68250740
17PRKCG1.54379500
18FER1.42008779
19BCKDK1.39605109
20EPHA31.37187566
21CAMKK21.33202460
22PRKACG1.28857674
23TNK21.28587530
24NLK1.27244646
25DAPK21.26120164
26EPHA41.17861222
27OXSR11.13938320
28MAPK131.10914160
29NUAK11.09597054
30FGFR21.05935009
31MAPK111.05443007
32IGF1R1.00740230
33AKT31.00736736
34ZAK1.00340018
35PRKCE1.00261466
36MAP3K40.97301671
37SGK20.96935850
38ERBB20.95508678
39FGFR30.95392740
40ERN10.95209952
41WNK40.94486293
42PRKAA10.93612015
43PAK30.93523472
44BCR0.92849177
45STK390.92537785
46LATS10.92382577
47MAPKAPK30.88875444
48FGFR40.86975281
49MAP2K40.85923242
50PRKCZ0.85092975
51TYK20.83272871
52ADRBK10.77490527
53PRKACA0.77320391
54SGK2230.75424408
55SGK4940.75424408
56STK380.74409152
57BRSK20.72325292
58TNIK0.68568054
59PRKG10.67743788
60CSNK1D0.66893017
61MAP3K70.64476230
62IRAK10.56215181
63CAMK1D0.55605077
64TIE10.54458679
65TXK0.54327855
66PRKCB0.53208462
67PRKCA0.53201885
68MAP3K20.51445661
69PDK20.51321708
70MAP2K60.50186311
71MKNK20.50175257
72MUSK0.49964107
73SGK10.49760571
74SGK30.49585273
75CSNK1A10.47389162
76PRKCQ0.47174164
77CAMK40.45399798
78EIF2AK30.45281069
79MAP2K70.44837622
80PRKACB0.44721241
81JAK10.44468331
82KIT0.43419827
83DYRK1A0.43109484
84CSF1R0.42771846
85TRPM70.42452473
86MYLK0.41649751
87CAMK1G0.40958566
88RPS6KA30.40522308
89PDPK10.39962718
90PDK10.39393840
91CSNK1G10.38963157
92MARK10.38639027
93IKBKB0.37300686
94ABL20.36976669
95TEC0.35949671
96CHUK0.35157836
97OBSCN0.33551302
98STK110.32259857
99ERBB30.31333150
100PTK2B0.31193245

Predicted pathways (KEGG)

RankGene SetZ-score
1Caffeine metabolism_Homo sapiens_hsa002324.77319332
2Primary bile acid biosynthesis_Homo sapiens_hsa001204.02606971
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.76262201
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.58450520
5Complement and coagulation cascades_Homo sapiens_hsa046103.48008169
6Retinol metabolism_Homo sapiens_hsa008303.44974896
7Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.42639440
8Chemical carcinogenesis_Homo sapiens_hsa052042.96296531
9Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.92164577
10Steroid hormone biosynthesis_Homo sapiens_hsa001402.74258066
11Pentose and glucuronate interconversions_Homo sapiens_hsa000402.67108426
12Drug metabolism - other enzymes_Homo sapiens_hsa009832.58305528
13Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.52201215
14Fatty acid degradation_Homo sapiens_hsa000712.37839851
15* Butanoate metabolism_Homo sapiens_hsa006502.28120766
16Tryptophan metabolism_Homo sapiens_hsa003802.24071815
17Arginine biosynthesis_Homo sapiens_hsa002202.13188247
18Phenylalanine metabolism_Homo sapiens_hsa003602.08330521
19Linoleic acid metabolism_Homo sapiens_hsa005912.06267805
20Tyrosine metabolism_Homo sapiens_hsa003501.97708575
21Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.95981896
22Histidine metabolism_Homo sapiens_hsa003401.90095581
23Bile secretion_Homo sapiens_hsa049761.79862114
24Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.76566273
25Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.70869981
26Starch and sucrose metabolism_Homo sapiens_hsa005001.49598237
27beta-Alanine metabolism_Homo sapiens_hsa004101.44531577
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.44008672
29Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.43725554
30Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.42752169
31Cyanoamino acid metabolism_Homo sapiens_hsa004601.38645918
32Peroxisome_Homo sapiens_hsa041461.36962889
33PPAR signaling pathway_Homo sapiens_hsa033201.33145543
34Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.27732559
35Cysteine and methionine metabolism_Homo sapiens_hsa002701.21983875
36Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.21889333
37Propanoate metabolism_Homo sapiens_hsa006401.16413719
38Arachidonic acid metabolism_Homo sapiens_hsa005901.13924615
39Vitamin B6 metabolism_Homo sapiens_hsa007501.10247088
40ABC transporters_Homo sapiens_hsa020101.09473545
41Staphylococcus aureus infection_Homo sapiens_hsa051501.08726220
42Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.07257441
43Fatty acid metabolism_Homo sapiens_hsa012120.93100921
44Arginine and proline metabolism_Homo sapiens_hsa003300.92777055
45Fat digestion and absorption_Homo sapiens_hsa049750.91872579
46Pyruvate metabolism_Homo sapiens_hsa006200.88550215
47Maturity onset diabetes of the young_Homo sapiens_hsa049500.87449168
48One carbon pool by folate_Homo sapiens_hsa006700.79288803
49alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.74097740
50Lysine degradation_Homo sapiens_hsa003100.67604991
51Biosynthesis of amino acids_Homo sapiens_hsa012300.67321868
52Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.60531778
53Carbon metabolism_Homo sapiens_hsa012000.56421052
54Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.52459658
55Prion diseases_Homo sapiens_hsa050200.49538363
562-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.45551493
57* Metabolic pathways_Homo sapiens_hsa011000.44728018
58Glycerolipid metabolism_Homo sapiens_hsa005610.44380450
59Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.39480597
60Selenocompound metabolism_Homo sapiens_hsa004500.35362121
61Sulfur metabolism_Homo sapiens_hsa009200.31807206
62Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.25103984
63Steroid biosynthesis_Homo sapiens_hsa001000.24829353
64Sulfur relay system_Homo sapiens_hsa041220.23873131
65Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.23518540
66Fatty acid elongation_Homo sapiens_hsa000620.22772145
67Nitrogen metabolism_Homo sapiens_hsa009100.20490050
68Serotonergic synapse_Homo sapiens_hsa047260.16985171
69Insulin resistance_Homo sapiens_hsa049310.16187112
70Pertussis_Homo sapiens_hsa051330.15909220
71Fatty acid biosynthesis_Homo sapiens_hsa000610.12522898
72Vitamin digestion and absorption_Homo sapiens_hsa049770.12391377
73Ether lipid metabolism_Homo sapiens_hsa005650.08420325
74Glucagon signaling pathway_Homo sapiens_hsa049220.06411143
75Glutathione metabolism_Homo sapiens_hsa004800.06161811
76Glycosaminoglycan degradation_Homo sapiens_hsa005310.06042441
77Ovarian steroidogenesis_Homo sapiens_hsa049130.02387670
78Adipocytokine signaling pathway_Homo sapiens_hsa049200.00430790
79Glycerophospholipid metabolism_Homo sapiens_hsa005640.00193147
80Nicotine addiction_Homo sapiens_hsa05033-0.1750235
81Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.1692508
82Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601-0.1611307
83Folate biosynthesis_Homo sapiens_hsa00790-0.1593589
84Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1517756
85Pentose phosphate pathway_Homo sapiens_hsa00030-0.1397449
86Type II diabetes mellitus_Homo sapiens_hsa04930-0.1346228
87Renin-angiotensin system_Homo sapiens_hsa04614-0.1152684
88African trypanosomiasis_Homo sapiens_hsa05143-0.1120433
89Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563-0.1095475
90Vascular smooth muscle contraction_Homo sapiens_hsa04270-0.1018288
91Phototransduction_Homo sapiens_hsa04744-0.0902415
92GABAergic synapse_Homo sapiens_hsa04727-0.0783080
93Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080-0.0702438
94AMPK signaling pathway_Homo sapiens_hsa04152-0.0640214
95Circadian rhythm_Homo sapiens_hsa04710-0.0537869
96Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0433276
97Fructose and mannose metabolism_Homo sapiens_hsa00051-0.0397156
98Systemic lupus erythematosus_Homo sapiens_hsa05322-0.0363296
99Sphingolipid metabolism_Homo sapiens_hsa00600-0.0178906
100Mineral absorption_Homo sapiens_hsa04978-0.0147772

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