ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	exogenous drug catabolic process (GO:0042738)	9.99181116
2	drug catabolic process (GO:0042737)	9.39490781
3	regulation of fibrinolysis (GO:0051917)	8.06852267
4	negative regulation of fibrinolysis (GO:0051918)	7.96138666
5	glyoxylate metabolic process (GO:0046487)	7.77418527
6	epoxygenase P450 pathway (GO:0019373)	7.72661961
7	omega-hydroxylase P450 pathway (GO:0097267)	7.57439818
8	L-phenylalanine catabolic process (GO:0006559)	7.56129465
9	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	7.56129465
10	regulation of protein activation cascade (GO:2000257)	6.97294620
11	complement activation, alternative pathway (GO:0006957)	6.94491279
12	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	6.82256694
13	L-phenylalanine metabolic process (GO:0006558)	6.82256694
14	regulation of complement activation (GO:0030449)	6.54358181
15	fibrinolysis (GO:0042730)	6.51662432
16	cellular glucuronidation (GO:0052695)	6.49870732
17	oxidative demethylation (GO:0070989)	6.27187248
18	glucuronate metabolic process (GO:0019585)	6.18597774
19	uronic acid metabolic process (GO:0006063)	6.18597774
20	negative regulation of cholesterol transport (GO:0032375)	6.14397613
21	negative regulation of sterol transport (GO:0032372)	6.14397613
22	aromatic amino acid family catabolic process (GO:0009074)	6.11954196
23	drug metabolic process (GO:0017144)	6.04299906
24	bile acid biosynthetic process (GO:0006699)	6.03126418
25	peptidyl-glutamic acid carboxylation (GO:0017187)	6.00205986
26	protein carboxylation (GO:0018214)	6.00205986
27	urea metabolic process (GO:0019627)	5.94598629
28	blood coagulation, intrinsic pathway (GO:0007597)	5.76811300
29	serine family amino acid catabolic process (GO:0009071)	5.63538522
30	ethanol oxidation (GO:0006069)	5.54633889
31	nitrogen cycle metabolic process (GO:0071941)	5.43357301
32	bile acid metabolic process (GO:0008206)	5.33177916
33	phenylpropanoid metabolic process (GO:0009698)	5.32584166
34	regulation of triglyceride catabolic process (GO:0010896)	5.32320521
35	S-adenosylmethionine metabolic process (GO:0046500)	5.28577776
36	regulation of plasminogen activation (GO:0010755)	5.16332435
37	glycine metabolic process (GO:0006544)	5.10345287
38	amino-acid betaine metabolic process (GO:0006577)	5.02670586
39	indole-containing compound catabolic process (GO:0042436)	4.83798401
40	indolalkylamine catabolic process (GO:0046218)	4.83798401
41	tryptophan catabolic process (GO:0006569)	4.83798401
42	negative regulation of hemostasis (GO:1900047)	4.80032479
43	negative regulation of blood coagulation (GO:0030195)	4.80032479
44	urea cycle (GO:0000050)	4.79260812
45	acylglycerol homeostasis (GO:0055090)	4.74145764
46	triglyceride homeostasis (GO:0070328)	4.74145764
47	bile acid and bile salt transport (GO:0015721)	4.74071294
48	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	4.73722833
49	alkaloid metabolic process (GO:0009820)	4.67534171
50	protein activation cascade (GO:0072376)	4.50677421
51	tyrosine metabolic process (GO:0006570)	4.44512790
52	ethanol metabolic process (GO:0006067)	4.42162681
53	phospholipid efflux (GO:0033700)	4.38520450
54	negative regulation of coagulation (GO:0050819)	4.36123594
55	response to mercury ion (GO:0046689)	4.31686916
56	negative regulation of protein activation cascade (GO:2000258)	4.27663414
57	negative regulation of wound healing (GO:0061045)	4.27075554
58	flavonoid metabolic process (GO:0009812)	4.23728916
59	high-density lipoprotein particle remodeling (GO:0034375)	4.16362031
60	imidazole-containing compound metabolic process (GO:0052803)	4.14442239
61	intestinal cholesterol absorption (GO:0030299)	4.14294815
62	fat-soluble vitamin biosynthetic process (GO:0042362)	4.12423244
63	protein-lipid complex remodeling (GO:0034368)	4.12217890
64	macromolecular complex remodeling (GO:0034367)	4.12217890
65	plasma lipoprotein particle remodeling (GO:0034369)	4.12217890
66	regulation of humoral immune response (GO:0002920)	4.11865551
67	acute-phase response (GO:0006953)	4.11770225
68	aromatic amino acid family metabolic process (GO:0009072)	4.11553917
69	positive regulation of blood coagulation (GO:0030194)	4.09120356
70	positive regulation of hemostasis (GO:1900048)	4.09120356
71	serine family amino acid metabolic process (GO:0009069)	4.07431469
72	tryptophan metabolic process (GO:0006568)	4.06403851
73	complement activation, classical pathway (GO:0006958)	4.05975670
74	complement activation (GO:0006956)	4.04867238
75	arginine metabolic process (GO:0006525)	4.04550952
76	L-methionine salvage (GO:0071267)	4.04446936
77	L-methionine biosynthetic process (GO:0071265)	4.04446936
78	amino acid salvage (GO:0043102)	4.04446936
79	negative regulation of lipase activity (GO:0060192)	4.01927989
80	cholesterol efflux (GO:0033344)	4.01739997
81	heme transport (GO:0015886)	3.99125046
82	alpha-amino acid catabolic process (GO:1901606)	3.91995011
83	cellular ketone body metabolic process (GO:0046950)	3.85539460
84	reverse cholesterol transport (GO:0043691)	3.77322386
85	positive regulation of coagulation (GO:0050820)	3.75692654
86	sodium-independent organic anion transport (GO:0043252)	3.75434497
87	positive regulation of triglyceride lipase activity (GO:0061365)	3.70630339
88	positive regulation of lipoprotein lipase activity (GO:0051006)	3.70630339
89	aminoglycoside antibiotic metabolic process (GO:0030647)	3.69779565
90	polyketide metabolic process (GO:0030638)	3.69059024
91	doxorubicin metabolic process (GO:0044598)	3.69059024
92	daunorubicin metabolic process (GO:0044597)	3.69059024
93	regulation of cholesterol esterification (GO:0010872)	3.65440166
94	drug transmembrane transport (GO:0006855)	3.60886000
95	positive regulation of heterotypic cell-cell adhesion (GO:0034116)	3.59720088
96	very-low-density lipoprotein particle assembly (GO:0034379)	3.58479960
97	cytolysis (GO:0019835)	3.54725736
98	negative regulation of complement activation (GO:0045916)	3.53714207
99	* xenobiotic metabolic process (GO:0006805)	3.52664952
100	disruption of cells of other organism involved in symbiotic interaction (GO:0051818)	3.52463764

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	8.73908049
2	EGR1_23403033_ChIP-Seq_LIVER_Mouse	6.09259767
3	RXR_22158963_ChIP-Seq_LIVER_Mouse	5.48979107
4	LXR_22158963_ChIP-Seq_LIVER_Mouse	4.74244969
5	PPARA_22158963_ChIP-Seq_LIVER_Mouse	4.58138786
6	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	3.98346810
7	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	3.92704003
8	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	3.53832295
9	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	3.43983080
10	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	2.74120807
11	* HNF4A_19822575_ChIP-Seq_HepG2_Human	1.93365950
12	FOXA2_19822575_ChIP-Seq_HepG2_Human	1.93037564
13	IGF1R_20145208_ChIP-Seq_DFB_Human	1.88710133
14	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.77974190
15	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.77464478
16	GBX2_23144817_ChIP-Seq_PC3_Human	1.76845665
17	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.75020671
18	HTT_18923047_ChIP-ChIP_STHdh_Human	1.74237641
19	TCF7L2_21901280_ChIP-Seq_H4IIE_Rat	1.61968552
20	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.55635197
21	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.47919301
22	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.46108316
23	BCAT_22108803_ChIP-Seq_LS180_Human	1.45854687
24	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.43742629
25	ER_23166858_ChIP-Seq_MCF-7_Human	1.43480059
26	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.39192339
27	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.36551267
28	TAF15_26573619_Chip-Seq_HEK293_Human	1.33013111
29	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	1.26215228
30	* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.26024293
31	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.25589482
32	VDR_22108803_ChIP-Seq_LS180_Human	1.24588461
33	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.22944142
34	IRF1_19129219_ChIP-ChIP_H3396_Human	1.19830230
35	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.19667205
36	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.18735465
37	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.18404911
38	CBP_20019798_ChIP-Seq_JUKART_Human	1.18192414
39	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.18192414
40	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.14575198
41	AR_20517297_ChIP-Seq_VCAP_Human	1.12103082
42	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.12081719
43	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.11481096
44	* CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.10649610
45	* KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.10433553
46	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.10112105
47	* STAT3_23295773_ChIP-Seq_U87_Human	1.10006014
48	TP53_18474530_ChIP-ChIP_U2OS_Human	1.09125631
49	CDX2_22108803_ChIP-Seq_LS180_Human	1.08409507
50	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.07816014
51	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	1.05691271
52	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.04318338
53	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.03926375
54	PHF8_20622853_ChIP-Seq_HELA_Human	1.03533217
55	TCF4_22108803_ChIP-Seq_LS180_Human	1.03057112
56	CBP_21632823_ChIP-Seq_H3396_Human	1.02821281
57	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.01450816
58	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.01223791
59	NANOG_19829295_ChIP-Seq_ESCs_Human	1.00769951
60	SOX2_19829295_ChIP-Seq_ESCs_Human	1.00769951
61	NFYA_21822215_ChIP-Seq_K562_Human	0.99752638
62	TCF4_23295773_ChIP-Seq_U87_Human	0.98696774
63	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.98206320
64	P300_19829295_ChIP-Seq_ESCs_Human	0.98189925
65	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.97934358
66	IRF8_22096565_ChIP-ChIP_GC-B_Human	0.97918388
67	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	0.97513342
68	OCT4_21477851_ChIP-Seq_ESCs_Mouse	0.96068048
69	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.95738941
70	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.95662494
71	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.94668415
72	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.94640781
73	CEBPB_22108803_ChIP-Seq_LS180_Human	0.94597840
74	PCGF2_27294783_Chip-Seq_ESCs_Mouse	0.94267467
75	ZNF274_21170338_ChIP-Seq_K562_Hela	0.94147082
76	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	0.93041437
77	GATA4_25053715_ChIP-Seq_YYC3_Human	0.91512247
78	SMAD4_21799915_ChIP-Seq_A2780_Human	0.91315404
79	OCT4_18555785_Chip-Seq_ESCs_Mouse	0.91088874
80	ETV1_20927104_ChIP-Seq_GIST48_Human	0.89350443
81	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.89208360
82	P53_22387025_ChIP-Seq_ESCs_Mouse	0.87899217
83	CBX2_22325352_ChIP-Seq_293T-Rex_Human	0.87168036
84	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.86977298
85	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.86767766
86	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.86767766
87	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.86566051
88	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	0.86415370
89	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.85601321
90	NCOR_22424771_ChIP-Seq_293T_Human	0.85211055
91	AR_25329375_ChIP-Seq_VCAP_Human	0.84437190
92	FOXA1_25552417_ChIP-Seq_VCAP_Human	0.83983786
93	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.83975911
94	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	0.83182134
95	P300_18555785_Chip-Seq_ESCs_Mouse	0.82867711
96	NRF2_20460467_ChIP-Seq_MEFs_Mouse	0.82853767
97	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	0.82853767
98	KAP1_22055183_ChIP-Seq_ESCs_Mouse	0.82829264
99	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.82325225
100	NFYB_21822215_ChIP-Seq_K562_Human	0.82156896

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002139_abnormal_hepatobiliary_system	9.61763685
2	MP0003195_calcinosis	6.38855344
3	MP0005085_abnormal_gallbladder_physiolo	6.11515112
4	MP0005365_abnormal_bile_salt	5.71285924
5	MP0005360_urolithiasis	5.63054262
6	MP0008875_abnormal_xenobiotic_pharmacok	5.34474046
7	MP0002138_abnormal_hepatobiliary_system	4.63826636
8	MP0003252_abnormal_bile_duct	4.49296190
9	MP0001666_abnormal_nutrient_absorption	3.16672182
10	MP0003868_abnormal_feces_composition	3.02292507
11	MP0010329_abnormal_lipoprotein_level	2.82797733
12	MP0009697_abnormal_copulation	2.59395273
13	MP0005332_abnormal_amino_acid	2.52158522
14	MP0002876_abnormal_thyroid_physiology	2.20182827
15	MP0009840_abnormal_foam_cell	2.04545239
16	MP0003806_abnormal_nucleotide_metabolis	1.87776713
17	MP0001764_abnormal_homeostasis	1.69978736
18	MP0000609_abnormal_liver_physiology	1.69917113
19	MP0002118_abnormal_lipid_homeostasis	1.69129642
20	MP0003191_abnormal_cellular_cholesterol	1.47485477
21	MP0010368_abnormal_lymphatic_system	1.31205068
22	MP0004019_abnormal_vitamin_homeostasis	1.30146828
23	MP0009643_abnormal_urine_homeostasis	1.20751050
24	MP0004043_abnormal_pH_regulation	1.19317967
25	MP0005408_hypopigmentation	1.18348598
26	MP0005319_abnormal_enzyme/_coenzyme	1.14115321
27	MP0005670_abnormal_white_adipose	1.05562572
28	MP0001661_extended_life_span	1.01715352
29	MP0005636_abnormal_mineral_homeostasis	0.97817582
30	MP0003011_delayed_dark_adaptation	0.97583986
31	MP0005584_abnormal_enzyme/coenzyme_acti	0.96771557
32	MP0009053_abnormal_anal_canal	0.96123001
33	MP0000598_abnormal_liver_morphology	0.93052749
34	MP0002168_other_aberrant_phenotype	0.92231551
35	MP0003656_abnormal_erythrocyte_physiolo	0.90270615
36	MP0005395_other_phenotype	0.90229446
37	MP0008872_abnormal_physiological_respon	0.89119400
38	MP0009642_abnormal_blood_homeostasis	0.84520427
39	MP0009764_decreased_sensitivity_to	0.81836591
40	MP0005376_homeostasis/metabolism_phenot	0.81774192
41	MP0003879_abnormal_hair_cell	0.80653171
42	MP0003186_abnormal_redox_activity	0.76157474
43	MP0002971_abnormal_brown_adipose	0.75765683
44	MP0002132_abnormal_respiratory_system	0.73237673
45	MP0001756_abnormal_urination	0.72383249
46	MP0008469_abnormal_protein_level	0.71497244
47	MP0003638_abnormal_response/metabolism_	0.68942612
48	MP0009763_increased_sensitivity_to	0.68162113
49	MP0005187_abnormal_penis_morphology	0.67540075
50	MP0002282_abnormal_trachea_morphology	0.66271308
51	MP0005535_abnormal_body_temperature	0.65898520
52	MP0005266_abnormal_metabolism	0.63692133
53	MP0005084_abnormal_gallbladder_morpholo	0.63104164
54	MP0002078_abnormal_glucose_homeostasis	0.62742815
55	MP0002928_abnormal_bile_duct	0.59011424
56	MP0001915_intracranial_hemorrhage	0.56782533
57	MP0005551_abnormal_eye_electrophysiolog	0.56285295
58	MP0000604_amyloidosis	0.54097714
59	MP0005646_abnormal_pituitary_gland	0.53924487
60	MP0005464_abnormal_platelet_physiology	0.52116783
61	MP0002136_abnormal_kidney_physiology	0.51148069
62	MP0003718_maternal_effect	0.49812121
63	MP0003690_abnormal_glial_cell	0.48963743
64	MP0005334_abnormal_fat_pad	0.48881923
65	MP0006036_abnormal_mitochondrial_physio	0.47955031
66	MP0005451_abnormal_body_composition	0.47171269
67	MP0005377_hearing/vestibular/ear_phenot	0.45000031
68	MP0003878_abnormal_ear_physiology	0.45000031
69	MP0004142_abnormal_muscle_tone	0.43768009
70	MP0005220_abnormal_exocrine_pancreas	0.41643138
71	MP0005647_abnormal_sex_gland	0.41492516
72	MP0005448_abnormal_energy_balance	0.40778127
73	MP0002249_abnormal_larynx_morphology	0.40189160
74	MP0008874_decreased_physiological_sensi	0.39169902
75	MP0003953_abnormal_hormone_level	0.36789102
76	MP0003646_muscle_fatigue	0.35406571
77	MP0004883_abnormal_blood_vessel	0.34966948
78	MP0004130_abnormal_muscle_cell	0.32667061
79	MP0000639_abnormal_adrenal_gland	0.32328017
80	MP0003959_abnormal_lean_body	0.32094952
81	MP0000249_abnormal_blood_vessel	0.30215091
82	MP0009115_abnormal_fat_cell	0.29808387
83	MP0001986_abnormal_taste_sensitivity	0.29157228
84	MP0009785_altered_susceptibility_to	0.29154623
85	MP0005164_abnormal_response_to	0.29104257
86	MP0010386_abnormal_urinary_bladder	0.28681535
87	MP0003633_abnormal_nervous_system	0.28365835
88	MP0005083_abnormal_biliary_tract	0.26264445
89	MP0000371_diluted_coat_color	0.25917753
90	MP0002909_abnormal_adrenal_gland	0.25024850
91	MP0001501_abnormal_sleep_pattern	0.24693311
92	MP0009765_abnormal_xenobiotic_induced	0.24457689
93	MP0002102_abnormal_ear_morphology	0.24428337
94	MP0005386_behavior/neurological_phenoty	0.23774110
95	MP0004924_abnormal_behavior	0.23774110
96	MP0003632_abnormal_nervous_system	0.22646011
97	MP0001324_abnormal_eye_pigmentation	0.22191248
98	MP0002135_abnormal_kidney_morphology	0.22140094
99	MP0008873_increased_physiological_sensi	0.21947403
100	MP0003631_nervous_system_phenotype	0.21930626

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of monocarboxylic acid metabolism (HP:0010996)	9.53129784
2	Deep venous thrombosis (HP:0002625)	9.45182952
3	Prolonged partial thromboplastin time (HP:0003645)	8.78162760
4	Complement deficiency (HP:0004431)	8.18208932
5	Abnormality of aromatic amino acid family metabolism (HP:0004338)	7.74246561
6	Hypobetalipoproteinemia (HP:0003563)	7.68809550
7	Conjugated hyperbilirubinemia (HP:0002908)	6.46064060
8	Abnormality of complement system (HP:0005339)	6.41980744
9	Joint hemorrhage (HP:0005261)	5.99853174
10	Hyperlipoproteinemia (HP:0010980)	5.56820766
11	Systemic lupus erythematosus (HP:0002725)	5.47730095
12	Intrahepatic cholestasis (HP:0001406)	5.00470996
13	Xanthomatosis (HP:0000991)	4.70082910
14	Glomerulonephritis (HP:0000099)	4.49365633
15	Abnormality of pyrimidine metabolism (HP:0004353)	4.46496128
16	Abnormality of the common coagulation pathway (HP:0010990)	4.44982326
17	Hypolipoproteinemia (HP:0010981)	4.33973553
18	Spontaneous abortion (HP:0005268)	4.24925667
19	Abnormality of the intrinsic pathway (HP:0010989)	3.93843426
20	Generalized aminoaciduria (HP:0002909)	3.88363237
21	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	3.80237232
22	Hyperglycinemia (HP:0002154)	3.75274357
23	Abnormality of glutamine family amino acid metabolism (HP:0010902)	3.56542786
24	Fat malabsorption (HP:0002630)	3.52601223
25	Recurrent gram-negative bacterial infections (HP:0005420)	3.51384167
26	Nephritis (HP:0000123)	3.43290876
27	Rickets (HP:0002748)	3.32695276
28	Abnormality of glycine metabolism (HP:0010895)	3.28124980
29	Abnormality of serine family amino acid metabolism (HP:0010894)	3.28124980
30	Hyperglycinuria (HP:0003108)	3.17579043
31	Hyperammonemia (HP:0001987)	3.10713973
32	Abnormality of methionine metabolism (HP:0010901)	3.09473774
33	Steatorrhea (HP:0002570)	2.94490933
34	Vascular calcification (HP:0004934)	2.93937792
35	Delayed CNS myelination (HP:0002188)	2.92624295
36	Gingival bleeding (HP:0000225)	2.85852127
37	Abnormality of serum amino acid levels (HP:0003112)	2.77767390
38	Abnormality of nucleobase metabolism (HP:0010932)	2.77311032
39	Osteomalacia (HP:0002749)	2.77158514
40	Hypercholesterolemia (HP:0003124)	2.77121655
41	Mitral stenosis (HP:0001718)	2.74657384
42	Hypoalphalipoproteinemia (HP:0003233)	2.72806649
43	Epidermoid cyst (HP:0200040)	2.70405158
44	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.69039655
45	Fair hair (HP:0002286)	2.68972928
46	Abnormality of urine glucose concentration (HP:0011016)	2.62399458
47	Glycosuria (HP:0003076)	2.62399458
48	Hyperphosphaturia (HP:0003109)	2.56964935
49	Reduced antithrombin III activity (HP:0001976)	2.56409670
50	Cardiovascular calcification (HP:0011915)	2.54355976
51	Hemorrhage of the eye (HP:0011885)	2.52704911
52	Abnormality of vitamin metabolism (HP:0100508)	2.41913062
53	Thrombophlebitis (HP:0004418)	2.40809399
54	Alkalosis (HP:0001948)	2.39640894
55	Hyperbilirubinemia (HP:0002904)	2.35158896
56	Menorrhagia (HP:0000132)	2.32554577
57	Proximal tubulopathy (HP:0000114)	2.26435314
58	Ketosis (HP:0001946)	2.24829147
59	Pulmonary embolism (HP:0002204)	2.23944509
60	Metabolic acidosis (HP:0001942)	2.22926751
61	Abnormality of sulfur amino acid metabolism (HP:0004339)	2.22012127
62	Hypophosphatemic rickets (HP:0004912)	2.22009495
63	Purpura (HP:0000979)	2.21812101
64	Hypochromic microcytic anemia (HP:0004840)	2.17697874
65	Arthropathy (HP:0003040)	2.17005247
66	Abnormal biliary tract physiology (HP:0012439)	2.12576398
67	Bile duct proliferation (HP:0001408)	2.12576398
68	Hepatocellular carcinoma (HP:0001402)	2.06918795
69	Bifid scrotum (HP:0000048)	2.03121218
70	Abnormality of purine metabolism (HP:0004352)	1.99767863
71	Abnormal urine phosphate concentration (HP:0012599)	1.97007230
72	Abnormality of proline metabolism (HP:0010907)	1.97002279
73	Hydroxyprolinuria (HP:0003080)	1.97002279
74	Enlarged kidneys (HP:0000105)	1.96984284
75	Irritability (HP:0000737)	1.94841176
76	Poikilocytosis (HP:0004447)	1.90405001
77	Generalized hypopigmentation of hair (HP:0011358)	1.85674715
78	Gout (HP:0001997)	1.83968639
79	Abnormality of fatty-acid metabolism (HP:0004359)	1.83573472
80	Increased circulating renin level (HP:0000848)	1.79526502
81	Potter facies (HP:0002009)	1.74969745
82	Facial shape deformation (HP:0011334)	1.74969745
83	Lethargy (HP:0001254)	1.72450505
84	Joint swelling (HP:0001386)	1.69487104
85	Gangrene (HP:0100758)	1.67469815
86	Abnormal platelet function (HP:0011869)	1.66571098
87	Impaired platelet aggregation (HP:0003540)	1.66571098
88	Increased mean platelet volume (HP:0011877)	1.66062475
89	Elevated alkaline phosphatase (HP:0003155)	1.65535701
90	Cerebral palsy (HP:0100021)	1.62141469
91	Abnormal urine output (HP:0012590)	1.62004246
92	Cholelithiasis (HP:0001081)	1.61932474
93	Hypochromic anemia (HP:0001931)	1.61326539
94	Metabolic alkalosis (HP:0200114)	1.60973334
95	Neonatal hypoglycemia (HP:0001998)	1.60585715
96	Abnormal gallbladder morphology (HP:0012437)	1.60413870
97	Ketoacidosis (HP:0001993)	1.60360594
98	Abnormal enzyme/coenzyme activity (HP:0012379)	1.60054007
99	Hypokalemic alkalosis (HP:0001949)	1.58187093
100	Abnormality of transition element cation homeostasis (HP:0011030)	1.56332616

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	6.35916386
2	WNK3	6.28926497
3	OXSR1	3.32527240
4	PIK3CG	2.77088911
5	TAOK3	2.63443825
6	NTRK3	2.19968242
7	ADRBK2	2.12937766
8	PINK1	2.03081103
9	MAP4K2	1.90723556
10	INSRR	1.90123169
11	PIK3CA	1.88711080
12	GRK1	1.83675708
13	ERN1	1.82026656
14	ACVR1B	1.81757970
15	BCKDK	1.70622422
16	WNK4	1.65135627
17	PRKCG	1.53829084
18	PRKAA2	1.53621451
19	BCR	1.50529652
20	PRKACG	1.44939488
21	STK39	1.37834659
22	NUAK1	1.36944643
23	EPHA4	1.30988655
24	FGFR4	1.28092119
25	BMPR1B	1.27059488
26	SGK2	1.26676503
27	CASK	1.23396638
28	EPHA3	1.21401004
29	MAP2K4	1.19324323
30	FER	1.07816721
31	MAPK13	1.06953000
32	MAP3K4	1.06434987
33	FGFR3	1.05301062
34	TNK2	1.00709428
35	TYK2	0.99838766
36	SGK494	0.97923881
37	SGK223	0.97923881
38	MAPKAPK3	0.97819616
39	MAPK11	0.97781556
40	IGF1R	0.97134695
41	PRKAA1	0.96974619
42	AKT3	0.90476358
43	FGFR2	0.89565796
44	STK38L	0.88919428
45	PRKCE	0.88608973
46	MAP3K12	0.88562524
47	NLK	0.86244473
48	CAMKK2	0.84656271
49	ERBB2	0.83779550
50	PRKACA	0.83231921
51	LATS1	0.82464168
52	PRKCZ	0.75030814
53	PAK3	0.74058700
54	SGK3	0.73826339
55	PRKG1	0.73133920
56	DAPK2	0.70729317
57	MUSK	0.70000794
58	MAP2K6	0.67167673
59	CSNK1D	0.62475540
60	BRSK2	0.62452010
61	IRAK1	0.62247929
62	TIE1	0.61928699
63	ADRBK1	0.61896669
64	ABL2	0.60397242
65	PRKCB	0.58532500
66	RIPK1	0.57779628
67	NEK9	0.57659734
68	SGK1	0.55648889
69	PRKCA	0.55551289
70	MYLK	0.54423133
71	EIF2AK3	0.53864075
72	MAP3K2	0.52616933
73	TRIM28	0.52154723
74	CSNK1A1	0.52008409
75	CSF1R	0.51336551
76	TBK1	0.45788999
77	JAK1	0.45084372
78	PDK2	0.44921384
79	MAP3K3	0.44352859
80	MAP3K5	0.44169766
81	PRKACB	0.44030705
82	RPS6KA3	0.43101754
83	MAP3K7	0.42937272
84	PDK1	0.39299932
85	PDPK1	0.38977499
86	TEC	0.38872911
87	TNIK	0.37797436
88	TXK	0.36494599
89	ZAK	0.35944064
90	PRKCQ	0.34919345
91	CSNK1G1	0.34419886
92	JAK2	0.33845649
93	EIF2AK1	0.33403938
94	MAP2K7	0.32810050
95	ERBB3	0.32605200
96	STK38	0.31764231
97	CSNK1E	0.31503461
98	KIT	0.31490518
99	OBSCN	0.31324738
100	DYRK1A	0.29942911

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Caffeine metabolism_Homo sapiens_hsa00232	4.58338160
2	Primary bile acid biosynthesis_Homo sapiens_hsa00120	4.08961838
3	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	3.85774695
4	Complement and coagulation cascades_Homo sapiens_hsa04610	3.61657287
5	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	3.58983101
6	Retinol metabolism_Homo sapiens_hsa00830	3.37848533
7	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	3.36389175
8	Chemical carcinogenesis_Homo sapiens_hsa05204	2.91142113
9	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	2.85510342
10	Steroid hormone biosynthesis_Homo sapiens_hsa00140	2.72264613
11	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	2.70186278
12	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	2.65024576
13	Drug metabolism - other enzymes_Homo sapiens_hsa00983	2.61467694
14	Fatty acid degradation_Homo sapiens_hsa00071	2.34325647
15	* Butanoate metabolism_Homo sapiens_hsa00650	2.22755831
16	Phenylalanine metabolism_Homo sapiens_hsa00360	2.17275595
17	Arginine biosynthesis_Homo sapiens_hsa00220	2.16812398
18	Tryptophan metabolism_Homo sapiens_hsa00380	2.09909664
19	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	2.07857840
20	Linoleic acid metabolism_Homo sapiens_hsa00591	1.96179133
21	Tyrosine metabolism_Homo sapiens_hsa00350	1.94296266
22	Histidine metabolism_Homo sapiens_hsa00340	1.80246829
23	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.78052905
24	Bile secretion_Homo sapiens_hsa04976	1.77725934
25	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.77105355
26	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.51219088
27	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.49966749
28	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.47991801
29	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.45818620
30	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.45254716
31	Peroxisome_Homo sapiens_hsa04146	1.40351305
32	beta-Alanine metabolism_Homo sapiens_hsa00410	1.38157636
33	PPAR signaling pathway_Homo sapiens_hsa03320	1.34479424
34	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.26912851
35	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.26881039
36	Propanoate metabolism_Homo sapiens_hsa00640	1.23545213
37	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.20522717
38	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.14720166
39	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.12251180
40	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.09937265
41	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.04578040
42	Pyruvate metabolism_Homo sapiens_hsa00620	0.98413885
43	Fatty acid metabolism_Homo sapiens_hsa01212	0.96179665
44	ABC transporters_Homo sapiens_hsa02010	0.95478201
45	Fat digestion and absorption_Homo sapiens_hsa04975	0.94711641
46	Arginine and proline metabolism_Homo sapiens_hsa00330	0.93204579
47	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.79105605
48	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.78139056
49	One carbon pool by folate_Homo sapiens_hsa00670	0.78049544
50	Carbon metabolism_Homo sapiens_hsa01200	0.69196372
51	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.67915778
52	Prion diseases_Homo sapiens_hsa05020	0.62938888
53	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.62599915
54	Lysine degradation_Homo sapiens_hsa00310	0.60471452
55	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.60321374
56	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.58813970
57	* Metabolic pathways_Homo sapiens_hsa01100	0.46563431
58	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.45555799
59	Sulfur metabolism_Homo sapiens_hsa00920	0.43429844
60	Glycerolipid metabolism_Homo sapiens_hsa00561	0.39619417
61	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.39042699
62	Sulfur relay system_Homo sapiens_hsa04122	0.35767321
63	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.34843395
64	Fatty acid elongation_Homo sapiens_hsa00062	0.34348876
65	Steroid biosynthesis_Homo sapiens_hsa00100	0.32578110
66	Selenocompound metabolism_Homo sapiens_hsa00450	0.31794419
67	Pertussis_Homo sapiens_hsa05133	0.20490133
68	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.16837773
69	Insulin resistance_Homo sapiens_hsa04931	0.13874880
70	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.12655204
71	Nitrogen metabolism_Homo sapiens_hsa00910	0.12111690
72	Glutathione metabolism_Homo sapiens_hsa00480	0.10262342
73	Serotonergic synapse_Homo sapiens_hsa04726	0.10120304
74	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.09997472
75	Glucagon signaling pathway_Homo sapiens_hsa04922	0.06588546
76	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.03899521
77	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.02440484
78	Ether lipid metabolism_Homo sapiens_hsa00565	0.02385997
79	Thyroid hormone synthesis_Homo sapiens_hsa04918	-0.2370219
80	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	-0.2189459
81	N-Glycan biosynthesis_Homo sapiens_hsa00510	-0.1875141
82	Phototransduction_Homo sapiens_hsa04744	-0.1872624
83	Galactose metabolism_Homo sapiens_hsa00052	-0.1785063
84	GABAergic synapse_Homo sapiens_hsa04727	-0.1778259
85	Vascular smooth muscle contraction_Homo sapiens_hsa04270	-0.1712855
86	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	-0.1371353
87	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	-0.1356196
88	African trypanosomiasis_Homo sapiens_hsa05143	-0.1355079
89	Circadian rhythm_Homo sapiens_hsa04710	-0.1290747
90	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	-0.1201923
91	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	-0.1110858
92	AMPK signaling pathway_Homo sapiens_hsa04152	-0.0847824
93	Sphingolipid metabolism_Homo sapiens_hsa00600	-0.0803480
94	Ovarian steroidogenesis_Homo sapiens_hsa04913	-0.0747654
95	Renin-angiotensin system_Homo sapiens_hsa04614	-0.0590793
96	Folate biosynthesis_Homo sapiens_hsa00790	-0.0583558
97	Pentose phosphate pathway_Homo sapiens_hsa00030	-0.0482569
98	Mineral absorption_Homo sapiens_hsa04978	-0.0285175
99	Glycerophospholipid metabolism_Homo sapiens_hsa00564	-0.0203492
100	Systemic lupus erythematosus_Homo sapiens_hsa05322	-0.0090922

ACSM2B

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »