ACSM3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)7.37566487
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.37566487
3L-phenylalanine metabolic process (GO:0006558)7.08003110
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.08003110
5aromatic amino acid family catabolic process (GO:0009074)6.63419069
6glyoxylate metabolic process (GO:0046487)6.57485461
7urate metabolic process (GO:0046415)6.40100011
8drug transmembrane transport (GO:0006855)6.24183935
9cysteine metabolic process (GO:0006534)6.19783554
10lysine catabolic process (GO:0006554)6.14436862
11lysine metabolic process (GO:0006553)6.14436862
12tryptophan catabolic process (GO:0006569)5.98604883
13indole-containing compound catabolic process (GO:0042436)5.98604883
14indolalkylamine catabolic process (GO:0046218)5.98604883
15fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.74377780
16tryptophan metabolic process (GO:0006568)5.68552347
17drug catabolic process (GO:0042737)5.64113352
18bile acid biosynthetic process (GO:0006699)5.47991467
19homocysteine metabolic process (GO:0050667)5.41592818
20kynurenine metabolic process (GO:0070189)5.38164871
21exogenous drug catabolic process (GO:0042738)5.33617130
22sulfur amino acid catabolic process (GO:0000098)5.33216074
23serine family amino acid catabolic process (GO:0009071)5.32197335
24amino-acid betaine metabolic process (GO:0006577)5.14382937
25drug transport (GO:0015893)5.11139518
26alpha-linolenic acid metabolic process (GO:0036109)4.96466135
27urea metabolic process (GO:0019627)4.83773981
28urea cycle (GO:0000050)4.83773981
29aromatic amino acid family metabolic process (GO:0009072)4.83655221
30cellular ketone body metabolic process (GO:0046950)4.77669359
31short-chain fatty acid metabolic process (GO:0046459)4.71414222
32triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.70706721
33definitive hemopoiesis (GO:0060216)4.70658467
34alpha-amino acid catabolic process (GO:1901606)4.69882954
35serine family amino acid metabolic process (GO:0009069)4.66207294
36bile acid metabolic process (GO:0008206)4.56842924
37cellular modified amino acid catabolic process (GO:0042219)4.51678943
38nitrogen cycle metabolic process (GO:0071941)4.49604938
39cellular amino acid catabolic process (GO:0009063)4.49353717
40tyrosine metabolic process (GO:0006570)4.38544787
41aspartate family amino acid catabolic process (GO:0009068)4.35230349
42serine family amino acid biosynthetic process (GO:0009070)4.27743327
43acetyl-CoA metabolic process (GO:0006084)4.26861401
44indolalkylamine metabolic process (GO:0006586)4.25444311
45fatty acid beta-oxidation (GO:0006635)4.25109516
46glutamate metabolic process (GO:0006536)4.22165472
47benzene-containing compound metabolic process (GO:0042537)4.21826228
48negative regulation of fibrinolysis (GO:0051918)4.20958820
49complement activation, alternative pathway (GO:0006957)4.18978198
50protein carboxylation (GO:0018214)4.16602671
51peptidyl-glutamic acid carboxylation (GO:0017187)4.16602671
52cellular glucuronidation (GO:0052695)4.14456421
53ketone body metabolic process (GO:1902224)4.12789003
54valine metabolic process (GO:0006573)4.10532617
55carnitine metabolic process (GO:0009437)4.08855934
56fatty acid oxidation (GO:0019395)4.08538470
57glycine metabolic process (GO:0006544)4.07719729
58aldehyde catabolic process (GO:0046185)4.06921736
59amine catabolic process (GO:0009310)4.06129049
60cellular biogenic amine catabolic process (GO:0042402)4.06129049
61coenzyme catabolic process (GO:0009109)4.05780921
62carboxylic acid catabolic process (GO:0046395)4.04968626
63organic acid catabolic process (GO:0016054)4.04968626
64high-density lipoprotein particle remodeling (GO:0034375)4.03516889
65phosphate ion transport (GO:0006817)4.02866843
66ethanol oxidation (GO:0006069)4.02242331
67regulation of protein activation cascade (GO:2000257)4.01146275
68lipid oxidation (GO:0034440)4.00639770
69regulation of fibrinolysis (GO:0051917)3.99337587
702-oxoglutarate metabolic process (GO:0006103)3.95268253
71S-adenosylmethionine metabolic process (GO:0046500)3.93624601
72branched-chain amino acid metabolic process (GO:0009081)3.92723895
73glucuronate metabolic process (GO:0019585)3.92112888
74uronic acid metabolic process (GO:0006063)3.92112888
75monocarboxylic acid catabolic process (GO:0072329)3.90451844
76regulation of triglyceride catabolic process (GO:0010896)3.90162137
77fatty acid catabolic process (GO:0009062)3.89847372
78drug metabolic process (GO:0017144)3.87273167
79phosphate ion transmembrane transport (GO:0035435)3.85582037
80dicarboxylic acid biosynthetic process (GO:0043650)3.84309075
81triglyceride homeostasis (GO:0070328)3.83453503
82acylglycerol homeostasis (GO:0055090)3.83453503
83protoporphyrinogen IX metabolic process (GO:0046501)3.81625335
84branched-chain amino acid catabolic process (GO:0009083)3.81306854
85negative regulation of sterol transport (GO:0032372)3.80368381
86negative regulation of cholesterol transport (GO:0032375)3.80368381
87response to mercury ion (GO:0046689)3.79077223
88organic cation transport (GO:0015695)3.78130701
89regulation of complement activation (GO:0030449)3.76347795
90quaternary ammonium group transport (GO:0015697)3.71035537
91terpenoid biosynthetic process (GO:0016114)3.70750425
92regulation of cholesterol homeostasis (GO:2000188)3.68636095
93bile acid and bile salt transport (GO:0015721)3.68628147
94very-low-density lipoprotein particle assembly (GO:0034379)3.64891508
95tricarboxylic acid metabolic process (GO:0072350)3.64015022
96regulation of bile acid biosynthetic process (GO:0070857)3.61246656
97flavonoid metabolic process (GO:0009812)3.59573212
98blood coagulation, intrinsic pathway (GO:0007597)3.59031610
99arginine metabolic process (GO:0006525)3.53370559
100reverse cholesterol transport (GO:0043691)3.50685562
101regulation of cholesterol esterification (GO:0010872)3.50183016
102protein-lipid complex remodeling (GO:0034368)3.49549782
103macromolecular complex remodeling (GO:0034367)3.49549782
104plasma lipoprotein particle remodeling (GO:0034369)3.49549782
105small molecule catabolic process (GO:0044282)3.45596212
106intestinal cholesterol absorption (GO:0030299)3.45260735
107aminoglycoside antibiotic metabolic process (GO:0030647)3.43695852
108regulation of histone H3-K4 methylation (GO:0051569)3.42630150
109diterpenoid biosynthetic process (GO:0016102)3.42331001
110negative regulation of protein activation cascade (GO:2000258)3.42054260
111tetrahydrofolate metabolic process (GO:0046653)3.41828020
112gas transport (GO:0015669)3.34968851
113erythrocyte maturation (GO:0043249)3.31013233
114protoporphyrinogen IX biosynthetic process (GO:0006782)3.28823968
115synapsis (GO:0007129)3.26309463
116regulation of translational fidelity (GO:0006450)3.19054640
117androgen biosynthetic process (GO:0006702)3.16941621
118oxygen transport (GO:0015671)3.10357588
119negative regulation of complement activation (GO:0045916)3.08278394
120positive regulation of histone H3-K4 methylation (GO:0051571)3.05760954
121DNA methylation involved in gamete generation (GO:0043046)3.05391370
122erythrocyte development (GO:0048821)3.01495648
123oxaloacetate metabolic process (GO:0006107)2.95760938
124interkinetic nuclear migration (GO:0022027)2.95362686
125poly(A)+ mRNA export from nucleus (GO:0016973)2.93181842
126imidazole-containing compound metabolic process (GO:0052803)2.92928869
127epoxygenase P450 pathway (GO:0019373)2.91995097
128positive regulation of granulocyte differentiation (GO:0030854)2.87606453
129methionine biosynthetic process (GO:0009086)2.87328013
130plasma lipoprotein particle assembly (GO:0034377)2.87224699
131nuclear pore complex assembly (GO:0051292)2.86094089
132detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.81966114
133low-density lipoprotein particle remodeling (GO:0034374)2.78288070
134isoprenoid biosynthetic process (GO:0008299)2.75525705
135ethanol metabolic process (GO:0006067)2.74189146
136iron ion import (GO:0097286)2.72798546
137proline biosynthetic process (GO:0006561)2.72334794
138regulation of histone H3-K27 methylation (GO:0061085)2.69731307
139aspartate family amino acid biosynthetic process (GO:0009067)2.69662474
140sulfur amino acid biosynthetic process (GO:0000097)2.68231064
141proline metabolic process (GO:0006560)2.66169402
142biotin metabolic process (GO:0006768)2.65386909
143sodium-independent organic anion transport (GO:0043252)2.65224741
144granulocyte differentiation (GO:0030851)2.64310123
145mRNA cleavage (GO:0006379)2.63671422
146dicarboxylic acid catabolic process (GO:0043649)2.63237883
147retinal metabolic process (GO:0042574)2.62665652
148folic acid-containing compound metabolic process (GO:0006760)2.62394724
149monoubiquitinated protein deubiquitination (GO:0035520)2.62193311
150plasma lipoprotein particle organization (GO:0071827)2.61578420
151nuclear pore organization (GO:0006999)2.61187452
152regulation of apoptotic cell clearance (GO:2000425)2.61149799
153one-carbon compound transport (GO:0019755)2.58741360
154succinate metabolic process (GO:0006105)2.58562571
155DNA replication checkpoint (GO:0000076)2.57869915
156resolution of meiotic recombination intermediates (GO:0000712)2.54526784
157negative regulation of fatty acid biosynthetic process (GO:0045717)2.53561925
158cholesterol efflux (GO:0033344)2.53099090
159oxidative phosphorylation (GO:0006119)2.52312183
160NAD biosynthetic process (GO:0009435)2.51131554

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse8.04835805
2PPARA_22158963_ChIP-Seq_LIVER_Mouse6.91807251
3LXR_22158963_ChIP-Seq_LIVER_Mouse6.18168053
4EGR1_23403033_ChIP-Seq_LIVER_Mouse6.12641870
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.32255671
6E2F7_22180533_ChIP-Seq_HELA_Human5.09482778
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.63761666
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.20263315
9* NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.72948035
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.51064324
11VDR_22108803_ChIP-Seq_LS180_Human3.04697776
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.79909001
13GATA1_19941826_ChIP-Seq_K562_Human2.70978561
14TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.51118755
15HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.35981940
16EST1_17652178_ChIP-ChIP_JURKAT_Human2.34025745
17ZNF274_21170338_ChIP-Seq_K562_Hela2.22923167
18TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.16165799
19SCL_19346495_ChIP-Seq_HPC-7_Human2.15423045
20HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.09988385
21NCOR1_26117541_ChIP-Seq_K562_Human2.05521779
22IGF1R_20145208_ChIP-Seq_DFB_Human2.04190490
23E2F4_17652178_ChIP-ChIP_JURKAT_Human2.03115724
24GABP_17652178_ChIP-ChIP_JURKAT_Human2.00713373
25ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.0946892
26SRF_21415370_ChIP-Seq_HL-1_Mouse1.96429355
27GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.92513574
28MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.90793425
29CLOCK_20551151_ChIP-Seq_293T_Human1.87228086
30PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.78056119
31SALL1_21062744_ChIP-ChIP_HESCs_Human1.77715157
32VDR_23849224_ChIP-Seq_CD4+_Human1.74963512
33FOXP3_21729870_ChIP-Seq_TREG_Human1.74614580
34ELK1_19687146_ChIP-ChIP_HELA_Human1.73430513
35ETS1_20019798_ChIP-Seq_JURKAT_Human1.71184997
36FOXA2_19822575_ChIP-Seq_HepG2_Human1.68696796
37HOXB4_20404135_ChIP-ChIP_EML_Mouse1.67590743
38HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.63120220
39PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.60933270
40JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.59582544
41* HNF4A_19822575_ChIP-Seq_HepG2_Human1.56554236
42ELF1_17652178_ChIP-ChIP_JURKAT_Human1.51737330
43HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.47140776
44POU3F2_20337985_ChIP-ChIP_501MEL_Human1.46845008
45STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.42976643
46MYC_18555785_ChIP-Seq_MESCs_Mouse1.41361831
47PADI4_21655091_ChIP-ChIP_MCF-7_Human1.38638747
48GATA1_22025678_ChIP-Seq_K562_Human1.35136373
49E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.34719774
50KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.33735927
51KDM5A_27292631_Chip-Seq_BREAST_Human1.32529908
52FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.32217872
53RARG_19884340_ChIP-ChIP_MEFs_Mouse1.31176753
54TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.29996225
55ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.29939339
56ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.28951847
57FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.28031725
58ESR1_21235772_ChIP-Seq_MCF-7_Human1.27791550
59ER_23166858_ChIP-Seq_MCF-7_Human1.25884609
60* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.25524448
61DCP1A_22483619_ChIP-Seq_HELA_Human1.25339715
62SPI1_23127762_ChIP-Seq_K562_Human1.23332455
63CIITA_25753668_ChIP-Seq_RAJI_Human1.21224385
64PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.19893946
65CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.18240241
66MYC_18358816_ChIP-ChIP_MESCs_Mouse1.17604306
67YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.17573961
68FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.17315356
69GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15686899
70ETV1_20927104_ChIP-Seq_GIST48_Human1.15320618
71GATA4_25053715_ChIP-Seq_YYC3_Human1.14737342
72CREB1_15753290_ChIP-ChIP_HEK293T_Human1.14570870
73EGR1_19374776_ChIP-ChIP_THP-1_Human1.10808863
74PHF8_20622853_ChIP-Seq_HELA_Human1.09897217
75ESR2_21235772_ChIP-Seq_MCF-7_Human1.08562275
76EWS_26573619_Chip-Seq_HEK293_Human1.07705646
77GABP_19822575_ChIP-Seq_HepG2_Human1.07703739
78CDX2_20551321_ChIP-Seq_CACO-2_Human1.07174554
79HTT_18923047_ChIP-ChIP_STHdh_Human1.06166988
80IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.05888282
81RBPJ_21746931_ChIP-Seq_IB4_Human1.05509623
82MYC_18940864_ChIP-ChIP_HL60_Human1.05346541
83E2F1_21310950_ChIP-Seq_MCF-7_Human1.04799798
84CBX2_22325352_ChIP-Seq_293T-Rex_Human1.03901219
85PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.03735107
86CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.03030235
87SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.02543537
88TTF2_22483619_ChIP-Seq_HELA_Human1.02277161
89HNFA_21074721_ChIP-Seq_CACO-2_Human1.01570869
90GATA6_21074721_ChIP-Seq_CACO-2_Human1.01177464
91IRF1_19129219_ChIP-ChIP_H3396_Human1.00835739
92* RXRA_24833708_ChIP-Seq_LIVER_Mouse0.98241174
93MYC_19030024_ChIP-ChIP_MESCs_Mouse0.97539247
94FUS_26573619_Chip-Seq_HEK293_Human0.97081903
95EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.96354958
96GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.95861338
97THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.95042002
98GATA3_26560356_Chip-Seq_TH2_Human0.94716048
99TP53_22573176_ChIP-Seq_HFKS_Human0.93996513
100SALL4_22934838_ChIP-ChIP_CD34+_Human0.93911013
101PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.91448629
102CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.90721774
103BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.89762184
104NFYB_21822215_ChIP-Seq_K562_Human0.89077357
105NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.88329925
106SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.87199552
107PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.86727625
108MYB_26560356_Chip-Seq_TH2_Human0.86675409
109AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.86497913
110CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.86449023
111MYB_26560356_Chip-Seq_TH1_Human0.86201527
112* GATA3_21878914_ChIP-Seq_MCF-7_Human0.85982613
113EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.85936361
114Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.82570946
115RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.80540913
116AUTS2_25519132_ChIP-Seq_293T-REX_Human0.79571926
117SALL4_18804426_ChIP-ChIP_XEN_Mouse0.77633839
118NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.77258501
119NRF2_20460467_ChIP-Seq_MEFs_Mouse0.77258501
120STAT3_1855785_ChIP-Seq_MESCs_Mouse0.75736360
121EGR1_19032775_ChIP-ChIP_M12_Human0.74596338
122IRF8_22096565_ChIP-ChIP_GC-B_Human0.74587657
123CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.74394010
124* KAP1_22055183_ChIP-Seq_ESCs_Mouse0.71643222
125ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.71443436
126FOXO3_23340844_ChIP-Seq_DLD1_Human0.70272131
127SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.69960270
128FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.69150206
129PPAR_26484153_Chip-Seq_NCI-H1993_Human0.69074240
130ESR1_15608294_ChIP-ChIP_MCF-7_Human0.68635474
131BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.67733055
132ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.66896265
133RAD21_21589869_ChIP-Seq_MESCs_Mouse0.66485234
134FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.65455798
135CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.64484843
136* GATA6_25053715_ChIP-Seq_YYC3_Human0.64047257
137TRIM28_21343339_ChIP-Seq_HEK293_Human0.63236877
138MYC_19915707_ChIP-ChIP_AK7_Human0.63197852
139NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.62907930
140ZNF263_19887448_ChIP-Seq_K562_Human0.62768457
141GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.62019406
142LXR_22292898_ChIP-Seq_THP-1_Human0.61703137
143* CEBPB_22108803_ChIP-Seq_LS180_Human0.61341480
144EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.61233178
145SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.60822707
146CBP_21632823_ChIP-Seq_H3396_Human0.59071171
147AR_20517297_ChIP-Seq_VCAP_Human0.58595206
148RARA_24833708_ChIP-Seq_LIVER_Mouse0.58325757
149FOXA1_25552417_ChIP-Seq_VCAP_Human0.57283071
150CDX2_22108803_ChIP-Seq_LS180_Human0.55579708
151PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.55498520
152* SOX2_20726797_ChIP-Seq_SW620_Human0.55179151
153STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.54670389
154FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.54545119
155PIAS1_25552417_ChIP-Seq_VCAP_Human0.53286915
156ESET_19884257_ChIP-Seq_ESCs_Mouse0.52335251
157ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.51152829
158STAT1_17558387_ChIP-Seq_HELA_Human0.51129388
159ESR1_20079471_ChIP-ChIP_T-47D_Human0.50664703
160PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.49486297
161RACK7_27058665_Chip-Seq_MCF-7_Human0.49121408
162PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.48196215
163GATA2_19941826_ChIP-Seq_K562_Human0.47837810
164TAF2_19829295_ChIP-Seq_ESCs_Human0.47453276
165TBX20_22080862_ChIP-Seq_HEART_Mouse0.46287530
166TBX20_22328084_ChIP-Seq_HEART_Mouse0.46287530
167BCAT_22108803_ChIP-Seq_LS180_Human0.46006473
168FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.45353204
169SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.44829068
170* AR_21909140_ChIP-Seq_LNCAP_Human0.44755828
171* RARB_24833708_ChIP-Seq_LIVER_Mouse0.44467187
172PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.44061197
173FOXH1_21741376_ChIP-Seq_EPCs_Human0.43806430
174GATA3_24758297_ChIP-Seq_MCF-7_Human0.43572766
175CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.42392920
176CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.41788434
177ERG_21242973_ChIP-ChIP_JURKAT_Human0.41543691

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis8.04517234
2MP0002139_abnormal_hepatobiliary_system7.91499482
3MP0005085_abnormal_gallbladder_physiolo5.76163256
4MP0005365_abnormal_bile_salt5.47428643
5MP0008875_abnormal_xenobiotic_pharmacok4.99841824
6MP0003252_abnormal_bile_duct3.88627916
7MP0005332_abnormal_amino_acid3.72789376
8MP0003806_abnormal_nucleotide_metabolis3.68898350
9MP0002132_abnormal_respiratory_system3.59962937
10MP0003195_calcinosis3.29612082
11MP0004019_abnormal_vitamin_homeostasis3.18419465
12MP0008995_early_reproductive_senescence3.08745350
13MP0010329_abnormal_lipoprotein_level3.01916864
14MP0002138_abnormal_hepatobiliary_system2.79445844
15MP0005083_abnormal_biliary_tract2.36010080
16MP0001666_abnormal_nutrient_absorption2.32811582
17MP0004043_abnormal_pH_regulation2.26903831
18MP0009840_abnormal_foam_cell2.25212696
19MP0009643_abnormal_urine_homeostasis2.20284916
20MP0002118_abnormal_lipid_homeostasis1.96397702
21MP0001545_abnormal_hematopoietic_system1.94717217
22MP0005397_hematopoietic_system_phenotyp1.94717217
23MP0000609_abnormal_liver_physiology1.90655785
24MP0003191_abnormal_cellular_cholesterol1.88543819
25MP0005319_abnormal_enzyme/_coenzyme1.88128765
26MP0005410_abnormal_fertilization1.78707772
27MP0008058_abnormal_DNA_repair1.77937525
28MP0005584_abnormal_enzyme/coenzyme_acti1.75239873
29MP0005646_abnormal_pituitary_gland1.73808854
30MP0000372_irregular_coat_pigmentation1.68355387
31MP0005636_abnormal_mineral_homeostasis1.67796020
32MP0003186_abnormal_redox_activity1.63011965
33MP0008057_abnormal_DNA_replication1.61598954
34MP0001764_abnormal_homeostasis1.59454936
35MP0005464_abnormal_platelet_physiology1.56365525
36MP0003786_premature_aging1.47762464
37MP0002396_abnormal_hematopoietic_system1.45275840
38MP0005451_abnormal_body_composition1.44961450
39MP0010094_abnormal_chromosome_stability1.43770477
40MP0003868_abnormal_feces_composition1.38697683
41MP0001756_abnormal_urination1.38389483
42MP0002160_abnormal_reproductive_system1.32850066
43MP0001765_abnormal_ion_homeostasis1.32715582
44MP0002136_abnormal_kidney_physiology1.26288653
45MP0005670_abnormal_white_adipose1.25936793
46MP0001929_abnormal_gametogenesis1.24665155
47MP0003111_abnormal_nucleus_morphology1.24376119
48MP0003943_abnormal_hepatobiliary_system1.20978009
49MP0004957_abnormal_blastocyst_morpholog1.20852754
50MP0005084_abnormal_gallbladder_morpholo1.17442887
51MP0008775_abnormal_heart_ventricle1.13179582
52MP0003122_maternal_imprinting1.11913425
53MP0006036_abnormal_mitochondrial_physio1.10193458
54MP0004808_abnormal_hematopoietic_stem1.10056604
55MP0005389_reproductive_system_phenotype1.08807401
56MP0002876_abnormal_thyroid_physiology1.08168918
57MP0000598_abnormal_liver_morphology1.06806467
58MP0005167_abnormal_blood-brain_barrier1.06262378
59MP0008877_abnormal_DNA_methylation1.05007404
60MP0003698_abnormal_male_reproductive1.01082239
61MP0009764_decreased_sensitivity_to0.98169273
62MP0003705_abnormal_hypodermis_morpholog0.96504943
63MP0008007_abnormal_cellular_replicative0.96422199
64MP0000678_abnormal_parathyroid_gland0.95993591
65MP0005535_abnormal_body_temperature0.94043851
66MP0003693_abnormal_embryo_hatching0.93530705
67MP0000653_abnormal_sex_gland0.90743743
68MP0009642_abnormal_blood_homeostasis0.90160000
69MP0002210_abnormal_sex_determination0.89937378
70MP0005647_abnormal_sex_gland0.89606937
71MP0001145_abnormal_male_reproductive0.86757724
72MP0003646_muscle_fatigue0.86734970
73MP0003567_abnormal_fetal_cardiomyocyte0.86475380
74MP0003011_delayed_dark_adaptation0.85896395
75MP0005408_hypopigmentation0.85714483
76MP0000639_abnormal_adrenal_gland0.84728411
77MP0001661_extended_life_span0.83987834
78MP0008469_abnormal_protein_level0.83810630
79MP0005666_abnormal_adipose_tissue0.83291346
80MP0009697_abnormal_copulation0.82765266
81MP0006292_abnormal_olfactory_placode0.81971863
82MP0005058_abnormal_lysosome_morphology0.81912499
83MP0002928_abnormal_bile_duct0.81730107
84MP0009763_increased_sensitivity_to0.80973487
85MP0000604_amyloidosis0.79527574
86MP0002078_abnormal_glucose_homeostasis0.78073032
87MP0002971_abnormal_brown_adipose0.77739990
88MP0005220_abnormal_exocrine_pancreas0.77657698
89MP0003656_abnormal_erythrocyte_physiolo0.76973004
90MP0005551_abnormal_eye_electrophysiolog0.76016908
91MP0003950_abnormal_plasma_membrane0.73662966
92MP0004130_abnormal_muscle_cell0.73560791
93MP0001697_abnormal_embryo_size0.72462084
94MP0005376_homeostasis/metabolism_phenot0.68718965
95MP0000689_abnormal_spleen_morphology0.67720936
96MP0009765_abnormal_xenobiotic_induced0.67074673
97MP0002722_abnormal_immune_system0.66177433
98MP0005379_endocrine/exocrine_gland_phen0.65989154
99MP0005334_abnormal_fat_pad0.64387817
100MP0004134_abnormal_chest_morphology0.64368851
101MP0003699_abnormal_female_reproductive0.64208678
102MP0000538_abnormal_urinary_bladder0.63206683
103MP0001119_abnormal_female_reproductive0.63142880
104MP0002089_abnormal_postnatal_growth/wei0.62835052
105MP0002168_other_aberrant_phenotype0.62494320
106MP0000230_abnormal_systemic_arterial0.62223143
107MP0001944_abnormal_pancreas_morphology0.61596367
108MP0001919_abnormal_reproductive_system0.61431391
109MP0004145_abnormal_muscle_electrophysio0.60592522
110MP0006035_abnormal_mitochondrial_morpho0.60437897
111MP0002019_abnormal_tumor_incidence0.59196552
112MP0003329_amyloid_beta_deposits0.59177958
113MP0002254_reproductive_system_inflammat0.57514043
114MP0005266_abnormal_metabolism0.57483590
115MP0003690_abnormal_glial_cell0.56940536
116MP0003638_abnormal_response/metabolism_0.56892837
117MP0005395_other_phenotype0.56201437
118MP0008961_abnormal_basal_metabolism0.54812360
119MP0004264_abnormal_extraembryonic_tissu0.54342489
120MP0003300_gastrointestinal_ulcer0.53471231
121MP0002796_impaired_skin_barrier0.49729291
122MP0002135_abnormal_kidney_morphology0.49240004
123MP0003953_abnormal_hormone_level0.48138040
124MP0003878_abnormal_ear_physiology0.46834384
125MP0005377_hearing/vestibular/ear_phenot0.46834384
126MP0003724_increased_susceptibility_to0.46033915
127MP0010234_abnormal_vibrissa_follicle0.44735115
128MP0004147_increased_porphyrin_level0.44105331
129MP0008872_abnormal_physiological_respon0.43946600
130MP0002837_dystrophic_cardiac_calcinosis0.43922289
131MP0010368_abnormal_lymphatic_system0.43431059
132MP0009053_abnormal_anal_canal0.43049779
133MP0001958_emphysema0.42263393
134MP0009672_abnormal_birth_weight0.41875909
135MP0005448_abnormal_energy_balance0.38966377
136MP0008874_decreased_physiological_sensi0.38044880
137MP0009115_abnormal_fat_cell0.35151856
138MP0008873_increased_physiological_sensi0.34537945
139MP0003959_abnormal_lean_body0.33865108
140MP0005166_decreased_susceptibility_to0.32465969
141MP0004782_abnormal_surfactant_physiolog0.32219493
142MP0003075_altered_response_to0.31603589
143MP0005375_adipose_tissue_phenotype0.30366672
144MP0002970_abnormal_white_adipose0.30118738
145MP0004885_abnormal_endolymph0.30091585
146MP0009384_cardiac_valve_regurgitation0.27637791
147MP0003718_maternal_effect0.27609682
148MP0001845_abnormal_inflammatory_respons0.27155884
149MP0002896_abnormal_bone_mineralization0.26330399

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.23195324
2Intrahepatic cholestasis (HP:0001406)6.03017050
3Xanthomatosis (HP:0000991)5.20587225
4Abnormality of monocarboxylic acid metabolism (HP:0010996)5.20405983
5Deep venous thrombosis (HP:0002625)5.19676404
6Hyperglycinuria (HP:0003108)5.17564816
7Abnormality of glutamine family amino acid metabolism (HP:0010902)5.12539815
8Gout (HP:0001997)4.94644906
9Abnormality of serine family amino acid metabolism (HP:0010894)4.79580585
10Abnormality of glycine metabolism (HP:0010895)4.79580585
11Ketosis (HP:0001946)4.76856264
12Hyperglycinemia (HP:0002154)4.59463933
13Hyperammonemia (HP:0001987)4.58636404
14Prolonged partial thromboplastin time (HP:0003645)4.38723606
15Hypobetalipoproteinemia (HP:0003563)4.34963410
16Poikilocytosis (HP:0004447)4.34548046
17Abnormality of aspartate family amino acid metabolism (HP:0010899)4.27474316
18Acanthocytosis (HP:0001927)4.20298435
19Ketoacidosis (HP:0001993)4.18364169
20Abnormality of the heme biosynthetic pathway (HP:0010472)4.14891598
21Abnormality of purine metabolism (HP:0004352)4.04636154
22Abnormality of sulfur amino acid metabolism (HP:0004339)3.94380210
23Hyperlipoproteinemia (HP:0010980)3.92330458
24Proximal tubulopathy (HP:0000114)3.86550038
25Abnormality of fatty-acid metabolism (HP:0004359)3.80517635
26Complement deficiency (HP:0004431)3.77335257
27Abnormality of nucleobase metabolism (HP:0010932)3.74976986
28Truncus arteriosus (HP:0001660)3.73480465
29Ileus (HP:0002595)3.69009801
30Reticulocytosis (HP:0001923)3.66069178
31Seborrheic dermatitis (HP:0001051)3.56833643
32Epidermoid cyst (HP:0200040)3.51567149
33Generalized aminoaciduria (HP:0002909)3.51147563
34Hypoglycemic coma (HP:0001325)3.50807810
35Delayed CNS myelination (HP:0002188)3.47779608
36Hyperuricemia (HP:0002149)3.45606709
37Increased purine levels (HP:0004368)3.45606709
38Alkalosis (HP:0001948)3.45323757
39Hyperthyroidism (HP:0000836)3.42633538
40Joint hemorrhage (HP:0005261)3.42074399
41Fat malabsorption (HP:0002630)3.35958908
42Hypolipoproteinemia (HP:0010981)3.33092195
43Abnormality of methionine metabolism (HP:0010901)3.26325332
44Vascular calcification (HP:0004934)3.24293329
45Hypokalemic alkalosis (HP:0001949)3.22492676
46Increased circulating renin level (HP:0000848)3.18435243
47Abnormality of pyrimidine metabolism (HP:0004353)3.15658651
48Abnormality of serum amino acid levels (HP:0003112)3.14965751
49Metabolic acidosis (HP:0001942)3.14735630
50Hyperactive renin-angiotensin system (HP:0000841)3.12730694
51Abnormality of dicarboxylic acid metabolism (HP:0010995)3.11365396
52Dicarboxylic aciduria (HP:0003215)3.11365396
53Abnormality of the common coagulation pathway (HP:0010990)3.09389153
54Abnormal gallbladder physiology (HP:0012438)3.07825495
55Cholecystitis (HP:0001082)3.07825495
56Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.06584880
57Conjugated hyperbilirubinemia (HP:0002908)3.04725830
58Abnormality of urine glucose concentration (HP:0011016)3.03806134
59Glycosuria (HP:0003076)3.03806134
60Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.02501153
61Metabolic alkalosis (HP:0200114)3.00496666
62Hypoalphalipoproteinemia (HP:0003233)2.98833954
63Abnormality of reticulocytes (HP:0004312)2.94265545
64Polycythemia (HP:0001901)2.93902641
65Lethargy (HP:0001254)2.92418210
66Abnormality of homocysteine metabolism (HP:0010919)2.92224089
67Homocystinuria (HP:0002156)2.92224089
68Cardiovascular calcification (HP:0011915)2.88395382
69Hypothermia (HP:0002045)2.84604868
70Hyperbilirubinemia (HP:0002904)2.78972167
71Hepatocellular carcinoma (HP:0001402)2.76973812
72Hydroxyprolinuria (HP:0003080)2.76312652
73Abnormality of proline metabolism (HP:0010907)2.76312652
74Abnormality of chloride homeostasis (HP:0011422)2.72270390
75Gonadal dysgenesis (HP:0000133)2.72155385
76Chromsome breakage (HP:0040012)2.71308974
77Prolonged bleeding time (HP:0003010)2.66080549
78Abnormality of complement system (HP:0005339)2.64717928
79Chromosomal breakage induced by crosslinking agents (HP:0003221)2.64137823
80Malnutrition (HP:0004395)2.61452663
81Hypomagnesemia (HP:0002917)2.61229884
82Rickets (HP:0002748)2.60723204
83Hypercholesterolemia (HP:0003124)2.57704122
84Pancreatic islet-cell hyperplasia (HP:0004510)2.57079791
85Vomiting (HP:0002013)2.56530776
86Abnormality of the intrinsic pathway (HP:0010989)2.56087227
87Spastic diplegia (HP:0001264)2.55121618
88Enlarged kidneys (HP:0000105)2.54549757
89Sensorimotor neuropathy (HP:0007141)2.49260207
90Abnormal urine output (HP:0012590)2.48204860
91Irritability (HP:0000737)2.47850971
92Abnormal hemoglobin (HP:0011902)2.46498438
93Cerebral edema (HP:0002181)2.43557920
94Polyuria (HP:0000103)2.40345076
95Neonatal onset (HP:0003623)2.40248502
96Increased serum pyruvate (HP:0003542)2.40226292
97Steatorrhea (HP:0002570)2.39906686
98Abnormality of renal excretion (HP:0011036)2.39598505
99Submucous cleft hard palate (HP:0000176)2.37071099
100Abnormal enzyme/coenzyme activity (HP:0012379)2.36771404
101Hyperphosphaturia (HP:0003109)2.35070999
102Nephrolithiasis (HP:0000787)2.34727079
103Renal cortical cysts (HP:0000803)2.34447387
104Late onset (HP:0003584)2.30871080
105Abnormality of glycolysis (HP:0004366)2.26353004
106Duplicated collecting system (HP:0000081)2.25486127
107Acute myeloid leukemia (HP:0004808)2.23281860
108Pancreatitis (HP:0001733)2.21060940
109Acute encephalopathy (HP:0006846)2.21039080
110Abnormality of the renal cortex (HP:0011035)2.16517618
111Renal tubular acidosis (HP:0001947)2.16295872
112Myocardial infarction (HP:0001658)2.15500086
113Abnormality of alkaline phosphatase activity (HP:0004379)2.14896822
114Abnormality of magnesium homeostasis (HP:0004921)2.13683241
115Systemic lupus erythematosus (HP:0002725)2.10748853
116Skin nodule (HP:0200036)2.08810378
117Abnormal urine phosphate concentration (HP:0012599)2.08625038
118Abnormality of the renal collecting system (HP:0004742)2.08530086
119Abnormality of DNA repair (HP:0003254)2.03892902
120Glomerulonephritis (HP:0000099)2.03376241
121Hypophosphatemia (HP:0002148)2.03170411
122Cerebral palsy (HP:0100021)2.02735509
123Nausea (HP:0002018)2.02126236
124Abnormality of male internal genitalia (HP:0000022)2.01521981
125Attenuation of retinal blood vessels (HP:0007843)2.01348567
126Hypophosphatemic rickets (HP:0004912)2.00884947
127Reduced antithrombin III activity (HP:0001976)2.00274928
128Methylmalonic acidemia (HP:0002912)1.99402405
129Confusion (HP:0001289)1.98391554
130Elevated alkaline phosphatase (HP:0003155)1.97739926
131Hypoglycemic seizures (HP:0002173)1.96644215
132Abnormality of renin-angiotensin system (HP:0000847)1.94250122
133Abnormality of cochlea (HP:0000375)1.93971918
134Spontaneous abortion (HP:0005268)1.93897572
135Male infertility (HP:0003251)1.92767426
136Beaking of vertebral bodies (HP:0004568)1.91693638
137Pancreatic cysts (HP:0001737)1.90688476
138Abnormal cartilage morphology (HP:0002763)1.90589502
139Pallor (HP:0000980)1.90529151
140Myelodysplasia (HP:0002863)1.89569692
141Azoospermia (HP:0000027)1.88754795
142Hyperaldosteronism (HP:0000859)1.88627635
143Opisthotonus (HP:0002179)1.87520771
144Mitral stenosis (HP:0001718)1.87518858
145Bowel incontinence (HP:0002607)1.86904197
146Overlapping toe (HP:0001845)1.86093571
147Lipid accumulation in hepatocytes (HP:0006561)1.84534740
148Abnormality of transition element cation homeostasis (HP:0011030)1.84504951
149Abnormal platelet function (HP:0011869)1.82441394
150Impaired platelet aggregation (HP:0003540)1.82441394
151Hypoplastic iliac wings (HP:0002866)1.81311465
152Cholelithiasis (HP:0001081)1.79772875
153Type I transferrin isoform profile (HP:0003642)1.79233704
154Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.79099475
155Abnormality of alanine metabolism (HP:0010916)1.79099475
156Hyperalaninemia (HP:0003348)1.79099475
157Male pseudohermaphroditism (HP:0000037)1.78501054
158Menorrhagia (HP:0000132)1.75509087
159Broad alveolar ridges (HP:0000187)1.75381578
160Birth length less than 3rd percentile (HP:0003561)1.75158721
161Abnormal gallbladder morphology (HP:0012437)1.74031740
162Hypertensive crisis (HP:0100735)1.73741062
163Abnormal large intestine physiology (HP:0012700)1.73190452
164Decreased central vision (HP:0007663)1.71504196
165Arthropathy (HP:0003040)1.70717068
166True hermaphroditism (HP:0010459)1.69806684
167Hypoparathyroidism (HP:0000829)1.66238810

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.54678655
2WNK45.37838701
3WNK34.50064749
4OXSR14.33206022
5EIF2AK13.51741273
6RIPK43.47387138
7FGFR43.21735805
8SIK12.90997352
9ERN12.82676559
10MST1R2.61452334
11STK392.48219849
12STK38L2.26710790
13INSRR2.24955862
14EIF2AK32.16581082
15LMTK22.15634641
16NUAK12.14362947
17ZAK2.11807398
18ERBB42.08285492
19BMPR22.02194578
20NME11.93814030
21BRSK21.89699273
22PDK41.88865846
23PDK31.88865846
24MAP4K21.88411738
25CLK11.85830983
26NEK21.83338337
27TEC1.81925428
28NTRK31.78419679
29PLK41.61144835
30MAPK111.56397960
31TTK1.55411898
32FRK1.54612848
33TAOK31.54089955
34MAP2K41.53957380
35EEF2K1.50504398
36BMPR1B1.47039068
37NEK11.46037287
38TRPM71.31719099
39MAPKAPK31.31186075
40TRIB31.30548914
41LATS11.29871806
42MAPKAPK51.29552170
43RAF11.27490313
44PKN21.25846476
45SGK2231.24946487
46SGK4941.24946487
47ABL21.24834811
48PIK3CG1.23323486
49PRKAA21.19751926
50PIK3CA1.16814075
51PINK11.15790548
52MAP3K71.15309101
53PDK21.12264330
54RPS6KB21.10684065
55GRK61.10123775
56AKT31.10080266
57PTK61.09772577
58KSR21.09530323
59MKNK11.06635556
60TLK11.05969254
61MET1.03525200
62CDK121.03071136
63ADRBK20.99192240
64SGK30.98615185
65FLT30.97992962
66TYK20.97358200
67MATK0.96198849
68BTK0.93210218
69MAP3K30.90744005
70ITK0.89922217
71EPHB10.89868652
72SYK0.89135403
73GSK3A0.89100010
74WEE10.88191634
75SGK20.87899023
76PRKG20.87897510
77CHEK20.87545024
78NEK90.86552897
79FGFR20.86515687
80MAP2K30.86247604
81ATR0.85518662
82RIPK10.85047968
83PRKAA10.85008482
84CAMK1D0.82867825
85JAK20.81146880
86STK380.80384560
87ATM0.80141071
88PRKCZ0.78914323
89RPS6KA50.76745477
90WNK10.73667943
91DYRK1B0.73476548
92MARK30.72816246
93PLK30.72353630
94DAPK20.70795740
95TIE10.70267630
96MAP3K140.70155899
97RET0.68925925
98SRPK10.68164833
99PDPK10.66916354
100CCNB10.65892668
101PTK20.65687986
102CDK80.65149395
103CDC70.65101138
104ERBB20.65091742
105KDR0.64407982
106VRK10.63643866
107MAP3K40.63257028
108PRKACG0.62257848
109CAMK1G0.61581142
110MAPK40.59503601
111MAPK150.58660361
112TGFBR20.55662582
113IRAK20.55184841
114CDK30.55182569
115TXK0.52136612
116IRAK30.52041015
117CSNK2A20.50800485
118MAPK30.50525580
119MAP2K60.49682140
120ACVR1B0.49488453
121MAP3K110.48951841
122PIM10.48747782
123JAK10.48458662
124MAPK120.48411054
125MAP3K100.47762787
126STK40.46313489
127CHEK10.46216516
128CDK10.45608840
129TBK10.44531230
130CSNK1E0.44061837
131BRD40.43868008
132CDK60.43802703
133PAK30.43187419
134CAMK2G0.42407472
135CDK70.42393521
136TNIK0.41838383
137LRRK20.41619964
138CSNK2A10.41619405
139MAPK130.41611629
140RPS6KA40.41192799
141PDK10.41176111
142CSK0.41040787
143CDK20.40148356
144MAP2K10.40021169
145RPS6KB10.39375728
146SCYL20.39373685
147EIF2AK20.39135114
148TAOK20.37168270
149PRKCQ0.34438783
150MYLK0.33607386
151EPHA40.32389123
152IRAK10.31980291
153CSNK1G10.31509464
154IGF1R0.31302029
155MAP3K20.30528137
156GRK10.27362621
157SGK10.24797703
158PRKCA0.24490596
159MAP3K50.22472069
160MTOR0.22065308
161FER0.21436435
162PRKCG0.20338554
163BMX0.20324082
164STK30.19836988
165MAPK70.19522191
166MAP2K20.19145382
167MAP3K60.19008514
168FGFR30.18923366
169PRKACA0.16083806

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.80109808
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.55580077
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.07015410
4Nitrogen metabolism_Homo sapiens_hsa009102.94675189
5Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.91188217
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.88208198
7Tryptophan metabolism_Homo sapiens_hsa003802.71588100
8Fatty acid degradation_Homo sapiens_hsa000712.69845200
9Pentose and glucuronate interconversions_Homo sapiens_hsa000402.66446192
10* Butanoate metabolism_Homo sapiens_hsa006502.65729386
11Propanoate metabolism_Homo sapiens_hsa006402.59196185
12Arginine biosynthesis_Homo sapiens_hsa002202.54677692
13Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.49683645
14Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.47867660
15Peroxisome_Homo sapiens_hsa041462.35954044
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.30594338
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.21317688
18Fatty acid metabolism_Homo sapiens_hsa012122.00784744
19beta-Alanine metabolism_Homo sapiens_hsa004101.96976426
20Complement and coagulation cascades_Homo sapiens_hsa046101.93142330
21Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.92433761
22Pyruvate metabolism_Homo sapiens_hsa006201.86461953
23PPAR signaling pathway_Homo sapiens_hsa033201.86435416
242-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.84364297
25Homologous recombination_Homo sapiens_hsa034401.84035957
26Histidine metabolism_Homo sapiens_hsa003401.79878701
27Cyanoamino acid metabolism_Homo sapiens_hsa004601.77465851
28Sulfur metabolism_Homo sapiens_hsa009201.71148271
29Steroid hormone biosynthesis_Homo sapiens_hsa001401.70296331
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.63928519
31Chemical carcinogenesis_Homo sapiens_hsa052041.63222243
32Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.62716600
33Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.56472846
34Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.55844443
35Bile secretion_Homo sapiens_hsa049761.55375472
36Phenylalanine metabolism_Homo sapiens_hsa003601.51018776
37Drug metabolism - other enzymes_Homo sapiens_hsa009831.48424443
38Selenocompound metabolism_Homo sapiens_hsa004501.48321419
39Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.46450988
40Retinol metabolism_Homo sapiens_hsa008301.40207750
41Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.39821316
42Carbon metabolism_Homo sapiens_hsa012001.36584482
43Starch and sucrose metabolism_Homo sapiens_hsa005001.33764039
44Caffeine metabolism_Homo sapiens_hsa002321.32880847
45Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.25004916
46Fanconi anemia pathway_Homo sapiens_hsa034601.23983716
47Fatty acid elongation_Homo sapiens_hsa000621.20240811
48Cysteine and methionine metabolism_Homo sapiens_hsa002701.19936214
49Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.17291267
50Tyrosine metabolism_Homo sapiens_hsa003501.16994763
51Arginine and proline metabolism_Homo sapiens_hsa003301.14844847
52Biosynthesis of amino acids_Homo sapiens_hsa012301.14001621
53Folate biosynthesis_Homo sapiens_hsa007901.12946542
54Staphylococcus aureus infection_Homo sapiens_hsa051501.11845637
55Vitamin digestion and absorption_Homo sapiens_hsa049771.11653747
56Mismatch repair_Homo sapiens_hsa034301.05301147
57Olfactory transduction_Homo sapiens_hsa047401.03750312
58Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.02408438
59Lysine degradation_Homo sapiens_hsa003101.01857977
60RNA degradation_Homo sapiens_hsa030181.01598323
61RNA transport_Homo sapiens_hsa030130.97728681
62ABC transporters_Homo sapiens_hsa020100.96615256
63Glutathione metabolism_Homo sapiens_hsa004800.95681163
64Maturity onset diabetes of the young_Homo sapiens_hsa049500.93363415
65Glycerolipid metabolism_Homo sapiens_hsa005610.91880521
66Steroid biosynthesis_Homo sapiens_hsa001000.88261163
67Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.87488457
68Basal transcription factors_Homo sapiens_hsa030220.84697179
69Fat digestion and absorption_Homo sapiens_hsa049750.83873499
70RNA polymerase_Homo sapiens_hsa030200.81182924
71Sulfur relay system_Homo sapiens_hsa041220.79236938
72DNA replication_Homo sapiens_hsa030300.78024786
73Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.75520270
74Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.73261633
75Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.72522654
76Ribosome_Homo sapiens_hsa030100.67109651
77Nucleotide excision repair_Homo sapiens_hsa034200.65457396
78Vitamin B6 metabolism_Homo sapiens_hsa007500.59688201
79Pentose phosphate pathway_Homo sapiens_hsa000300.59280121
80Spliceosome_Homo sapiens_hsa030400.58779334
81Purine metabolism_Homo sapiens_hsa002300.58480233
82* Metabolic pathways_Homo sapiens_hsa011000.51409323
83Base excision repair_Homo sapiens_hsa034100.51044638
84Non-homologous end-joining_Homo sapiens_hsa034500.50450324
85One carbon pool by folate_Homo sapiens_hsa006700.47857801
86SNARE interactions in vesicular transport_Homo sapiens_hsa041300.46103688
87Ether lipid metabolism_Homo sapiens_hsa005650.45252771
88mRNA surveillance pathway_Homo sapiens_hsa030150.45047867
89N-Glycan biosynthesis_Homo sapiens_hsa005100.44132763
90Fructose and mannose metabolism_Homo sapiens_hsa000510.42851596
91Pyrimidine metabolism_Homo sapiens_hsa002400.36191315
92Fatty acid biosynthesis_Homo sapiens_hsa000610.35082474
93Protein export_Homo sapiens_hsa030600.31673724
94Phototransduction_Homo sapiens_hsa047440.30438056
95Parkinsons disease_Homo sapiens_hsa050120.29327599
96alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.25804941
97Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.25357951
98Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.24964971
99Galactose metabolism_Homo sapiens_hsa000520.23957239
100Insulin resistance_Homo sapiens_hsa049310.22162148
101Adipocytokine signaling pathway_Homo sapiens_hsa049200.21653938
102Mineral absorption_Homo sapiens_hsa049780.17434957
103Protein digestion and absorption_Homo sapiens_hsa049740.12041339
104Other glycan degradation_Homo sapiens_hsa005110.08446794
105Glycerophospholipid metabolism_Homo sapiens_hsa005640.08297555
106Linoleic acid metabolism_Homo sapiens_hsa005910.07739804
107Glucagon signaling pathway_Homo sapiens_hsa049220.07702933
108AMPK signaling pathway_Homo sapiens_hsa041520.07333968
109Prion diseases_Homo sapiens_hsa050200.06429760
110Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.05885526
111Collecting duct acid secretion_Homo sapiens_hsa049660.05836703
112Renin-angiotensin system_Homo sapiens_hsa046140.04782290
113Glycosaminoglycan degradation_Homo sapiens_hsa005310.04607722
114Carbohydrate digestion and absorption_Homo sapiens_hsa049730.03426714
115Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.03098721
116Arachidonic acid metabolism_Homo sapiens_hsa005900.00304742
117Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.00173765
118Hepatitis C_Homo sapiens_hsa05160-0.1604275
119Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1487512
120Regulation of autophagy_Homo sapiens_hsa04140-0.1364427
121Insulin signaling pathway_Homo sapiens_hsa04910-0.1270171
122Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.1234625
123Oxidative phosphorylation_Homo sapiens_hsa00190-0.1192636
124Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1168328
125Lysosome_Homo sapiens_hsa04142-0.0758916
126Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961-0.0620242
127Thyroid hormone synthesis_Homo sapiens_hsa04918-0.0230512
128Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960-0.0103803

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