ACSM4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sensory perception of smell (GO:0007608)9.92294587
2phospholipid scrambling (GO:0017121)9.19433986
3phenylpropanoid metabolic process (GO:0009698)8.50608796
4L-serine transport (GO:0015825)8.34506457
5xenobiotic catabolic process (GO:0042178)8.26531520
6one-carbon compound transport (GO:0019755)7.75773437
7negative regulation of activin receptor signaling pathway (GO:0032926)7.41858215
8serine transport (GO:0032329)7.41388028
9L-ascorbic acid metabolic process (GO:0019852)6.41362797
10regulation of cholesterol biosynthetic process (GO:0045540)6.05435465
11regulation of secondary heart field cardioblast proliferation (GO:0003266)6.00399036
12regulation of cardioblast proliferation (GO:0003264)6.00399036
13water-soluble vitamin biosynthetic process (GO:0042364)5.86738316
14chemosensory behavior (GO:0007635)5.77540825
15sequestering of extracellular ligand from receptor (GO:0035581)5.65331307
16cellular response to hepatocyte growth factor stimulus (GO:0035729)5.63496954
17response to hepatocyte growth factor (GO:0035728)5.63496954
18response to nitrosative stress (GO:0051409)5.48938956
19sensory perception of chemical stimulus (GO:0007606)5.37527889
20regulation of mesoderm development (GO:2000380)5.28663648
21somite rostral/caudal axis specification (GO:0032525)5.24123437
22negative regulation of fatty acid transport (GO:2000192)5.16329097
23anterior/posterior axis specification, embryo (GO:0008595)5.01377369
24response to inactivity (GO:0014854)4.89627303
25regulation of activin receptor signaling pathway (GO:0032925)4.83847611
26outer ear morphogenesis (GO:0042473)4.81411208
27cell migration involved in gastrulation (GO:0042074)4.78253597
28primitive streak formation (GO:0090009)4.76474134
29anterior/posterior axis specification (GO:0009948)4.71042961
30regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.65357271
31Rap protein signal transduction (GO:0032486)4.57171762
32vitamin catabolic process (GO:0009111)4.53157264
33fat-soluble vitamin catabolic process (GO:0042363)4.53157264
34negative regulation of cardiac muscle cell apoptotic process (GO:0010667)4.46190095
35negative regulation of lipase activity (GO:0060192)4.45462999
36regulation of cardioblast differentiation (GO:0051890)4.39932677
37calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)4.24860964
38regulation of acyl-CoA biosynthetic process (GO:0050812)4.22241772
39pharyngeal system development (GO:0060037)4.04146502
40polyol transport (GO:0015791)4.01619590
41hydrogen peroxide biosynthetic process (GO:0050665)3.96161155
42endoderm formation (GO:0001706)3.93663196
43hormone catabolic process (GO:0042447)3.91793358
44phagocytosis, engulfment (GO:0006911)3.90042585
45response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.89056453
463-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.88642605
47purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.88642605
48regulation of cofactor metabolic process (GO:0051193)3.87792554
49regulation of coenzyme metabolic process (GO:0051196)3.87792554
50muscle cell migration (GO:0014812)3.85066768
51regulation of lipoprotein metabolic process (GO:0050746)3.83268410
52regulation of phospholipase A2 activity (GO:0032429)3.82886829
53nucleotide transmembrane transport (GO:1901679)3.82534026
54regulation of cholesterol metabolic process (GO:0090181)3.81955075
55growth hormone secretion (GO:0030252)3.78934690
56glomerulus development (GO:0032835)3.74862869
57platelet dense granule organization (GO:0060155)3.74747027
58extracellular fibril organization (GO:0043206)3.72832114
59relaxation of cardiac muscle (GO:0055119)3.71445622
60glutathione derivative biosynthetic process (GO:1901687)3.71000634
61glutathione derivative metabolic process (GO:1901685)3.71000634
62glutathione metabolic process (GO:0006749)3.67450841
63regulation of skeletal muscle contraction (GO:0014819)3.65437409
64renal absorption (GO:0070293)3.62311081
65cellular response to estrogen stimulus (GO:0071391)3.62192589
66negative regulation of axon extension involved in axon guidance (GO:0048843)3.62060234
67regulation of superoxide anion generation (GO:0032928)3.61701755
68carnitine metabolic process (GO:0009437)3.60482868
69auditory receptor cell differentiation (GO:0042491)3.58765843
70fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.57891406
71cellular response to follicle-stimulating hormone stimulus (GO:0071372)3.56466423
72flavonoid metabolic process (GO:0009812)3.55483421
73signal transduction involved in regulation of gene expression (GO:0023019)3.49367828
74reactive oxygen species biosynthetic process (GO:1903409)3.48663983
75sulfur amino acid catabolic process (GO:0000098)3.47972598
76aorta morphogenesis (GO:0035909)3.44650342
77cell differentiation involved in metanephros development (GO:0072202)3.44432368
78intracellular lipid transport (GO:0032365)3.44150776
79response to interferon-beta (GO:0035456)3.44033265
80mRNA cleavage (GO:0006379)3.42171246
81galactose metabolic process (GO:0006012)3.41988409
82Notch signaling involved in heart development (GO:0061314)3.41843419
83benzene-containing compound metabolic process (GO:0042537)3.40285317
84aldehyde catabolic process (GO:0046185)3.40121698
85relaxation of muscle (GO:0090075)3.38485905
86UDP-N-acetylglucosamine metabolic process (GO:0006047)3.38208552
87pericardium development (GO:0060039)3.35399447
88tooth mineralization (GO:0034505)3.33965049
89middle ear morphogenesis (GO:0042474)3.33413611
90phosphatidylserine metabolic process (GO:0006658)3.33387709
91vitamin biosynthetic process (GO:0009110)3.30295902
92response to BMP (GO:0071772)3.29297337
93cellular response to BMP stimulus (GO:0071773)3.29297337
94regulation of sulfur metabolic process (GO:0042762)3.29188287
95positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.29142500
96heme transport (GO:0015886)3.26728148
97regulation of cell proliferation involved in heart morphogenesis (GO:2000136)3.26524939
98positive regulation of cholesterol efflux (GO:0010875)3.26305184
99embryonic axis specification (GO:0000578)3.26254152
100myoblast migration (GO:0051451)3.26208639
101positive regulation of astrocyte differentiation (GO:0048711)3.25998811
102negative regulation of receptor activity (GO:2000272)3.24652524
103response to interferon-alpha (GO:0035455)3.21950058
104generation of neurons (GO:0048699)3.21829310
105opioid receptor signaling pathway (GO:0038003)3.20866750
106extracellular regulation of signal transduction (GO:1900115)3.19029297
107extracellular negative regulation of signal transduction (GO:1900116)3.19029297
108regulation of membrane lipid distribution (GO:0097035)3.17327429
109positive regulation of catecholamine secretion (GO:0033605)3.15198570
110neuron fate specification (GO:0048665)3.14033224
111outflow tract septum morphogenesis (GO:0003148)3.13686856
112negative regulation of chondrocyte differentiation (GO:0032331)3.12351203
113alkaloid metabolic process (GO:0009820)3.09972226
114pyrimidine-containing compound transmembrane transport (GO:0072531)3.09553410
115regulation of axon extension involved in axon guidance (GO:0048841)3.08841874
116notochord development (GO:0030903)3.06263816
117positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190)3.06003112
118regulation of cardiac muscle cell apoptotic process (GO:0010665)3.05459650
119transmission of nerve impulse (GO:0019226)3.04554515
120removal of superoxide radicals (GO:0019430)3.04217555
121cellular response to superoxide (GO:0071451)3.04217555
122cellular response to oxygen radical (GO:0071450)3.04217555
123peristalsis (GO:0030432)2.99137731
124negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.98918428
125neurofilament cytoskeleton organization (GO:0060052)2.98880173
126positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.98342164
127activation of protein kinase B activity (GO:0032148)2.98152398
128positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.97379594
129DNA replication-dependent nucleosome organization (GO:0034723)2.97169035
130DNA replication-dependent nucleosome assembly (GO:0006335)2.97169035
131embryonic foregut morphogenesis (GO:0048617)2.97001803
132energy homeostasis (GO:0097009)2.95559907
133regulation of phosphoprotein phosphatase activity (GO:0043666)2.95170633
134ovulation cycle (GO:0042698)2.94054555
135ER overload response (GO:0006983)2.93843464
136positive regulation of protein autophosphorylation (GO:0031954)2.93766945
137cellular copper ion homeostasis (GO:0006878)2.93410494
138establishment of epithelial cell polarity (GO:0090162)2.90406973
139positive regulation of response to oxidative stress (GO:1902884)2.90211808
140positive regulation of cellular response to oxidative stress (GO:1900409)2.90211808
141myeloid leukocyte mediated immunity (GO:0002444)2.89757728
142bone remodeling (GO:0046849)2.89682532
143regulation of branching involved in ureteric bud morphogenesis (GO:0090189)2.88157753
144positive regulation of cholesterol transport (GO:0032376)2.88108115
145positive regulation of sterol transport (GO:0032373)2.88108115
146fibril organization (GO:0097435)2.87797189
147alditol phosphate metabolic process (GO:0052646)2.85905151
148gastrulation (GO:0007369)2.85732949
149DNA double-strand break processing (GO:0000729)2.84979093
150desmosome organization (GO:0002934)2.83711444
151negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.83399607
152replicative senescence (GO:0090399)2.81370492
153multicellular organism reproduction (GO:0032504)2.81248141
154limb bud formation (GO:0060174)2.80153877
155negative regulation of striated muscle cell apoptotic process (GO:0010664)2.79321613
156positive regulation of steroid biosynthetic process (GO:0010893)2.77645947
157regulation of hydrogen peroxide-induced cell death (GO:1903205)2.77299711
158detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.77037897
159retina homeostasis (GO:0001895)2.76552831
160relaxation of smooth muscle (GO:0044557)2.75065809
161aggressive behavior (GO:0002118)2.74482493
162positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.74305229
163negative regulation of organic acid transport (GO:0032891)2.73963343
164lung secretory cell differentiation (GO:0061140)2.73600798
165membrane invagination (GO:0010324)2.73540044
166histone exchange (GO:0043486)2.73291543
167negative regulation of axon guidance (GO:1902668)2.72782852
168negative regulation of viral genome replication (GO:0045071)2.69323091
169negative regulation of homotypic cell-cell adhesion (GO:0034111)2.69138526
170tight junction assembly (GO:0070830)2.68943383
171negative regulation of response to reactive oxygen species (GO:1901032)2.68836769
172negative regulation of platelet activation (GO:0010544)2.68729863
173regulation of type B pancreatic cell apoptotic process (GO:2000674)2.67306203
174fucose catabolic process (GO:0019317)2.66035855
175L-fucose metabolic process (GO:0042354)2.66035855
176L-fucose catabolic process (GO:0042355)2.66035855
177nucleotide-sugar biosynthetic process (GO:0009226)2.65700897
178metanephric mesenchyme development (GO:0072075)2.65449854
179heterotypic cell-cell adhesion (GO:0034113)2.64209781
180regulation of oxidative phosphorylation (GO:0002082)2.62901029
181substrate adhesion-dependent cell spreading (GO:0034446)2.62518218
182xenobiotic metabolic process (GO:0006805)2.61023710
183regulation of RIG-I signaling pathway (GO:0039535)2.59831460
184organ formation (GO:0048645)2.58197072
185binding of sperm to zona pellucida (GO:0007339)2.58080773
186regulation of integrin-mediated signaling pathway (GO:2001044)2.57828021
187decidualization (GO:0046697)2.57370055
188regulation of axon guidance (GO:1902667)2.57335140
189regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.56238026
190fibrinolysis (GO:0042730)2.56193370
191behavioral response to ethanol (GO:0048149)2.55032084
192embryonic pattern specification (GO:0009880)2.52122282
193negative regulation of viral entry into host cell (GO:0046597)2.51794934
194proteasome assembly (GO:0043248)2.51644676
195uronic acid metabolic process (GO:0006063)15.0407585
196glucuronate metabolic process (GO:0019585)15.0407585
197cellular glucuronidation (GO:0052695)13.7587533

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.09309785
2CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human4.12989631
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.80954142
4* SMAD3_21741376_ChIP-Seq_HESCs_Human3.34557354
5TRIM28_21343339_ChIP-Seq_HEK293_Human3.13626796
6* SMAD4_21741376_ChIP-Seq_HESCs_Human3.09849109
7EOMES_21245162_ChIP-Seq_HESCs_Human3.06659915
8BP1_19119308_ChIP-ChIP_Hs578T_Human2.89240167
9FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.78284542
10P300_19829295_ChIP-Seq_ESCs_Human2.71354587
11SMAD3_21741376_ChIP-Seq_EPCs_Human2.67235501
12SMAD2/3_21741376_ChIP-Seq_EPCs_Human2.66895854
13VDR_22108803_ChIP-Seq_LS180_Human2.55938349
14ESR1_20079471_ChIP-ChIP_T-47D_Human2.51441417
15ZNF217_24962896_ChIP-Seq_MCF-7_Human2.51065893
16SMAD4_21741376_ChIP-Seq_EPCs_Human2.49157256
17AR_21909140_ChIP-Seq_LNCAP_Human2.43639107
18ESR2_21235772_ChIP-Seq_MCF-7_Human2.29747726
19EGR1_19374776_ChIP-ChIP_THP-1_Human2.26824799
20GATA2_21666600_ChIP-Seq_HMVEC_Human2.14641221
21ESR1_21235772_ChIP-Seq_MCF-7_Human2.09315369
22GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.05332444
23DROSHA_22980978_ChIP-Seq_HELA_Human1.97830791
24SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.93053210
25RARG_19884340_ChIP-ChIP_MEFs_Mouse1.92244823
26EP300_21415370_ChIP-Seq_HL-1_Mouse1.88328488
27AHR_22903824_ChIP-Seq_MCF-7_Human1.87315475
28CTBP2_25329375_ChIP-Seq_LNCAP_Human1.85771410
29SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.84331257
30CDX2_20551321_ChIP-Seq_CACO-2_Human1.84091836
31ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.83559734
32NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.78783792
33IGF1R_20145208_ChIP-Seq_DFB_Human1.77620137
34THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.75721311
35POU3F2_20337985_ChIP-ChIP_501MEL_Human1.70520197
36PPAR_26484153_Chip-Seq_NCI-H1993_Human1.69657865
37LXR_22158963_ChIP-Seq_LIVER_Mouse1.69132973
38ERG_21242973_ChIP-ChIP_JURKAT_Human1.68889971
39CDX2_19796622_ChIP-Seq_MESCs_Mouse1.68123640
40CJUN_26792858_Chip-Seq_BT549_Human1.66045460
41AR_21572438_ChIP-Seq_LNCaP_Human1.65822585
42CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.64800505
43ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.64771924
44RNF2_18974828_ChIP-Seq_MESCs_Mouse1.57117251
45EZH2_18974828_ChIP-Seq_MESCs_Mouse1.57117251
46SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.56483983
47SOX2_20726797_ChIP-Seq_SW620_Human1.55107866
48NANOG_19829295_ChIP-Seq_ESCs_Human1.52313342
49SOX2_19829295_ChIP-Seq_ESCs_Human1.52313342
50CDX2_22108803_ChIP-Seq_LS180_Human1.51767383
51ARNT_22903824_ChIP-Seq_MCF-7_Human1.49253357
52TP53_18474530_ChIP-ChIP_U2OS_Human1.46128373
53SMAD_19615063_ChIP-ChIP_OVARY_Human1.45726903
54ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.43598066
55SOX9_24532713_ChIP-Seq_HFSC_Mouse1.37750801
56FLI1_27457419_Chip-Seq_LIVER_Mouse1.37263304
57PCGF2_27294783_Chip-Seq_ESCs_Mouse1.36914739
58FOXM1_26456572_ChIP-Seq_MCF-7_Human1.36410469
59EED_16625203_ChIP-ChIP_MESCs_Mouse1.35886274
60NRF2_20460467_ChIP-Seq_MEFs_Mouse1.35859057
61NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.35859057
62EGR1_23403033_ChIP-Seq_LIVER_Mouse1.35365315
63CLOCK_20551151_ChIP-Seq_293T_Human1.33961345
64PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.33680765
65SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.33423661
66SOX2_27498859_Chip-Seq_STOMACH_Mouse1.32780365
67ZNF274_21170338_ChIP-Seq_K562_Hela1.32315138
68CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30079812
69FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.29718990
70TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.29624114
71SALL4_18804426_ChIP-ChIP_XEN_Mouse1.29085089
72RXR_22158963_ChIP-Seq_LIVER_Mouse1.25899942
73ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.24231783
74SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.24213209
75SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.23276006
76SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.23276006
77SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22947875
78RING1B_27294783_Chip-Seq_NPCs_Mouse1.21856354
79* BRD4_25478319_ChIP-Seq_HGPS_Human1.21266604
80FOXH1_21741376_ChIP-Seq_EPCs_Human1.21246670
81UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.20688529
82TCF4_22108803_ChIP-Seq_LS180_Human1.19168398
83ZNF263_19887448_ChIP-Seq_K562_Human1.19156731
84VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.18696912
85RUNX1_27514584_Chip-Seq_MCF-7_Human1.18406940
86SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.18139363
87ELK1_19687146_ChIP-ChIP_HELA_Human1.17774995
88STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.17283024
89ZFP57_27257070_Chip-Seq_ESCs_Mouse1.17021590
90RNF2_27304074_Chip-Seq_ESCs_Mouse1.16465155
91PPARA_22158963_ChIP-Seq_LIVER_Mouse1.16214296
92GATA3_24758297_ChIP-Seq_MCF-7_Human1.16099561
93ER_23166858_ChIP-Seq_MCF-7_Human1.15948331
94KLF5_25053715_ChIP-Seq_YYC3_Human1.13962107
95WT1_19549856_ChIP-ChIP_CCG9911_Human1.13894751
96SOX2_18555785_ChIP-Seq_MESCs_Mouse1.13448220
97JARID2_20075857_ChIP-Seq_MESCs_Mouse1.13080733
98CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.12774380
99MTF2_20144788_ChIP-Seq_MESCs_Mouse1.12203683
100* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.10839647
101CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.10722021
102ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.10547499
103AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.10142447
104TOP2B_26459242_ChIP-Seq_MCF-7_Human1.09552048
105NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.09453647
106PIAS1_25552417_ChIP-Seq_VCAP_Human1.09023599
107PRDM14_20953172_ChIP-Seq_ESCs_Human1.08541890
108VDR_24787735_ChIP-Seq_THP-1_Human1.07212202
109TCF4_18268006_ChIP-ChIP_LS174T_Human1.06180030
110EZH2_27294783_Chip-Seq_NPCs_Mouse1.05334710
111BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.04839968
112RING1B_27294783_Chip-Seq_ESCs_Mouse1.04212236
113SMAD4_21799915_ChIP-Seq_A2780_Human1.04202631
114TP53_20018659_ChIP-ChIP_R1E_Mouse1.03799461
115ESR1_15608294_ChIP-ChIP_MCF-7_Human1.02767762
116P53_22127205_ChIP-Seq_FIBROBLAST_Human1.02493872
117BMI1_23680149_ChIP-Seq_NPCS_Mouse1.02104584
118NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.02098034
119MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.01679437
120SUZ12_27294783_Chip-Seq_ESCs_Mouse1.01489373
121TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.00447006
122* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00347608
123EZH2_27294783_Chip-Seq_ESCs_Mouse0.99968591
124EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.99141870
125SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.98281011
126IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.97477182
127CBP_20019798_ChIP-Seq_JUKART_Human0.97477182
128SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.97119090
129GABP_17652178_ChIP-ChIP_JURKAT_Human0.96737440
130NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96354415
131PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95050995
132GATA4_25053715_ChIP-Seq_YYC3_Human0.94950183
133RUNX2_22187159_ChIP-Seq_PCA_Human0.94356074
134WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.94327846
135TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.93823077
136TP53_16413492_ChIP-PET_HCT116_Human0.93617377
137AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.93608556
138OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.93157449
139IRF8_22096565_ChIP-ChIP_GC-B_Human0.92828367
140STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.92422307
141BCAT_22108803_ChIP-Seq_LS180_Human0.92228636
142CTBP1_25329375_ChIP-Seq_LNCAP_Human0.91872059
143RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.91831871
144SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.91531840
145CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.90611332
146CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.89773092
147AR_25329375_ChIP-Seq_VCAP_Human0.89545225
148CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.89124298
149GBX2_23144817_ChIP-Seq_PC3_Human0.89122525
150TAF15_26573619_Chip-Seq_HEK293_Human0.88811582
151KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.88290917
152Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.88235591
153HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.88196348
154PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.88139533
155RACK7_27058665_Chip-Seq_MCF-7_Human0.87781182
156JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.87749451
157EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.87375756
158TP63_23658742_ChIP-Seq_EP156T_Human0.87013742
159CRX_20693478_ChIP-Seq_RETINA_Mouse0.85906859
160KLF5_20875108_ChIP-Seq_MESCs_Mouse0.85902580
161WT1_25993318_ChIP-Seq_PODOCYTE_Human0.85849513
162FOXH1_21741376_ChIP-Seq_ESCs_Human0.84116955
163DCP1A_22483619_ChIP-Seq_HELA_Human0.83909920

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008004_abnormal_stomach_pH9.44541002
2MP0008789_abnormal_olfactory_epithelium8.06316202
3MP0008875_abnormal_xenobiotic_pharmacok7.26106775
4* MP0005394_taste/olfaction_phenotype6.55523726
5* MP0005499_abnormal_olfactory_system6.55523726
6* MP0001984_abnormal_olfaction5.80692401
7MP0006054_spinal_hemorrhage5.05942819
8MP0010030_abnormal_orbit_morphology3.50293037
9MP0003878_abnormal_ear_physiology3.12063257
10MP0005377_hearing/vestibular/ear_phenot3.12063257
11MP0003195_calcinosis2.74053251
12MP0001346_abnormal_lacrimal_gland2.63483707
13MP0005410_abnormal_fertilization2.59941332
14MP0002233_abnormal_nose_morphology2.54172286
15MP0002254_reproductive_system_inflammat2.23943619
16MP0003186_abnormal_redox_activity2.23130089
17MP0003136_yellow_coat_color2.19939925
18MP0003119_abnormal_digestive_system2.18580903
19MP0002877_abnormal_melanocyte_morpholog2.18446006
20MP0000678_abnormal_parathyroid_gland2.03947973
21MP0005058_abnormal_lysosome_morphology2.02955550
22MP0003806_abnormal_nucleotide_metabolis2.02035019
23MP0002736_abnormal_nociception_after1.97094812
24MP0000613_abnormal_salivary_gland1.95699766
25MP0009780_abnormal_chondrocyte_physiolo1.89223199
26MP0000762_abnormal_tongue_morphology1.76787559
27MP0009697_abnormal_copulation1.75445318
28MP0009379_abnormal_foot_pigmentation1.73432940
29MP0005084_abnormal_gallbladder_morpholo1.70155062
30MP0002102_abnormal_ear_morphology1.69494805
31MP0002249_abnormal_larynx_morphology1.59956801
32MP0009840_abnormal_foam_cell1.56917687
33MP0000049_abnormal_middle_ear1.56071941
34MP0002138_abnormal_hepatobiliary_system1.56033438
35MP0003315_abnormal_perineum_morphology1.54024589
36MP0000534_abnormal_ureter_morphology1.53912772
37MP0002009_preneoplasia1.53204016
38MP0003868_abnormal_feces_composition1.47127761
39MP0005365_abnormal_bile_salt1.46995855
40MP0005464_abnormal_platelet_physiology1.45485590
41MP0001666_abnormal_nutrient_absorption1.44080754
42MP0005220_abnormal_exocrine_pancreas1.39707966
43MP0005330_cardiomyopathy1.38374331
44MP0009250_abnormal_appendicular_skeleto1.37371735
45MP0003279_aneurysm1.35407998
46MP0003191_abnormal_cellular_cholesterol1.34134126
47MP0002127_abnormal_cardiovascular_syste1.32990001
48MP0004133_heterotaxia1.31727957
49MP0004510_myositis1.30068320
50MP0001664_abnormal_digestion1.28380768
51MP0004084_abnormal_cardiac_muscle1.26326333
52MP0000343_altered_response_to1.22425962
53MP0001485_abnormal_pinna_reflex1.18779640
54MP0003942_abnormal_urinary_system1.14082614
55MP0001919_abnormal_reproductive_system1.11769803
56MP0003300_gastrointestinal_ulcer1.11722579
57MP0001529_abnormal_vocalization1.11201523
58MP0000467_abnormal_esophagus_morphology1.09815963
59MP0001915_intracranial_hemorrhage1.09587573
60MP0003385_abnormal_body_wall1.09117428
61MP0001958_emphysema1.07213596
62MP0010352_gastrointestinal_tract_polyps1.04108705
63MP0002277_abnormal_respiratory_mucosa1.02952589
64MP0000465_gastrointestinal_hemorrhage1.01541489
65MP0010329_abnormal_lipoprotein_level0.98804486
66MP0009053_abnormal_anal_canal0.98711562
67MP0003941_abnormal_skin_development0.98654524
68MP0001672_abnormal_embryogenesis/_devel0.97729893
69MP0005380_embryogenesis_phenotype0.97729893
70MP0002084_abnormal_developmental_patter0.93998484
71MP0003755_abnormal_palate_morphology0.92227206
72MP0010386_abnormal_urinary_bladder0.91088170
73MP0004270_analgesia0.90859531
74MP0003566_abnormal_cell_adhesion0.90281350
75MP0005360_urolithiasis0.89030958
76MP0001968_abnormal_touch/_nociception0.88311517
77MP0008995_early_reproductive_senescence0.86770285
78MP0004147_increased_porphyrin_level0.86284323
79MP0000538_abnormal_urinary_bladder0.85722237
80MP0003638_abnormal_response/metabolism_0.85639360
81MP0003172_abnormal_lysosome_physiology0.84785086
82MP0006138_congestive_heart_failure0.84599465
83MP0002653_abnormal_ependyma_morphology0.83930507
84MP0001853_heart_inflammation0.83315207
85MP0005187_abnormal_penis_morphology0.82703338
86MP0003937_abnormal_limbs/digits/tail_de0.81633911
87MP0004134_abnormal_chest_morphology0.81186870
88MP0001270_distended_abdomen0.81115261
89MP0005408_hypopigmentation0.80995452
90MP0006292_abnormal_olfactory_placode0.80850813
91MP0008932_abnormal_embryonic_tissue0.80699471
92MP0005388_respiratory_system_phenotype0.80439873
93MP0002133_abnormal_respiratory_system0.80439873
94MP0005409_darkened_coat_color0.80054002
95MP0002295_abnormal_pulmonary_circulatio0.79750297
96MP0003984_embryonic_growth_retardation0.79363472
97MP0005248_abnormal_Harderian_gland0.78892021
98MP0001730_embryonic_growth_arrest0.78471474
99MP0005167_abnormal_blood-brain_barrier0.78446278
100MP0002098_abnormal_vibrissa_morphology0.78254533
101MP0005085_abnormal_gallbladder_physiolo0.77824122
102MP0002088_abnormal_embryonic_growth/wei0.77059017
103MP0001756_abnormal_urination0.76973706
104MP0009384_cardiac_valve_regurgitation0.76018877
105MP0006072_abnormal_retinal_apoptosis0.75950399
106MP0003943_abnormal_hepatobiliary_system0.75508564
107MP0005197_abnormal_uvea_morphology0.75368145
108MP0001849_ear_inflammation0.74112705
109MP0004215_abnormal_myocardial_fiber0.73123031
110MP0004885_abnormal_endolymph0.73010401
111MP0000470_abnormal_stomach_morphology0.69954498
112MP0002128_abnormal_blood_circulation0.69912912
113MP0003890_abnormal_embryonic-extraembry0.69850858
114MP0003075_altered_response_to0.69294931
115MP0000462_abnormal_digestive_system0.68126780
116MP0002086_abnormal_extraembryonic_tissu0.67731241
117MP0004036_abnormal_muscle_relaxation0.65565850
118MP0005671_abnormal_response_to0.65541541
119MP0000749_muscle_degeneration0.64571546
120MP0005389_reproductive_system_phenotype0.63966034
121MP0010094_abnormal_chromosome_stability0.63796113
122MP0005647_abnormal_sex_gland0.63639078
123MP0002111_abnormal_tail_morphology0.62562642
124MP0000372_irregular_coat_pigmentation0.62339551
125MP0004782_abnormal_surfactant_physiolog0.61309160
126MP0003950_abnormal_plasma_membrane0.61174541
127MP0002092_abnormal_eye_morphology0.60991798
128MP0002177_abnormal_outer_ear0.60640097
129MP0001851_eye_inflammation0.60603694
130MP0005310_abnormal_salivary_gland0.60105320
131MP0000767_abnormal_smooth_muscle0.59664957
132MP0002972_abnormal_cardiac_muscle0.58053955
133MP0001929_abnormal_gametogenesis0.57898791
134MP0005266_abnormal_metabolism0.57426079
135MP0003453_abnormal_keratinocyte_physiol0.57193759
136MP0001177_atelectasis0.56740805
137MP0004264_abnormal_extraembryonic_tissu0.56430658
138MP0003936_abnormal_reproductive_system0.55590921
139MP0001663_abnormal_digestive_system0.55167995
140MP0010368_abnormal_lymphatic_system0.55066145
141MP0002160_abnormal_reproductive_system0.55017275
142MP0010234_abnormal_vibrissa_follicle0.54887794
143MP0009278_abnormal_bone_marrow0.54454067
144MP0001188_hyperpigmentation0.53423197
145MP0003656_abnormal_erythrocyte_physiolo0.53371635
146MP0002925_abnormal_cardiovascular_devel0.53093315
147MP0000383_abnormal_hair_follicle0.53086420
148MP0001661_extended_life_span0.52784307
149MP0003828_pulmonary_edema0.52602445
150MP0005023_abnormal_wound_healing0.52425509
151MP0002085_abnormal_embryonic_tissue0.51797229
152MP0009745_abnormal_behavioral_response0.51710257
153MP0002163_abnormal_gland_morphology0.51492959
154MP0001501_abnormal_sleep_pattern0.50792788
155MP0001963_abnormal_hearing_physiology0.50788901
156MP0002090_abnormal_vision0.50232600
157MP0005381_digestive/alimentary_phenotyp0.49288436
158MP0005171_absent_coat_pigmentation0.48997539
159MP0000015_abnormal_ear_pigmentation0.48902760
160MP0003698_abnormal_male_reproductive0.48770410
161MP0002132_abnormal_respiratory_system0.46886856
162MP0002938_white_spotting0.46792899
163MP0004272_abnormal_basement_membrane0.46789125
164MP0002168_other_aberrant_phenotype0.46258625
165MP0010678_abnormal_skin_adnexa0.46081380
166MP0001340_abnormal_eyelid_morphology0.43712941
167MP0005646_abnormal_pituitary_gland0.42091558
168MP0003938_abnormal_ear_development0.40543114
169MP0002116_abnormal_craniofacial_bone0.38944982
170MP0000631_abnormal_neuroendocrine_gland0.38037673
171MP0002060_abnormal_skin_morphology0.37647721
172MP0000163_abnormal_cartilage_morphology0.36931587
173MP0000026_abnormal_inner_ear0.36821024
174MP0008872_abnormal_physiological_respon0.35469117
175MP0002139_abnormal_hepatobiliary_system0.34622316
176MP0003935_abnormal_craniofacial_develop0.34159758
177MP0002697_abnormal_eye_size0.31504400

Predicted human phenotypes

RankGene SetZ-score
1Lip pit (HP:0100267)7.97762593
2Gonadal dysgenesis (HP:0000133)6.50245948
3Renal tubular acidosis (HP:0001947)5.48633154
4Stenosis of the external auditory canal (HP:0000402)5.32634222
5Abnormality of the fetal cardiovascular system (HP:0010948)5.09126358
6Abnormal umbilical cord blood vessels (HP:0011403)5.09126358
7Single umbilical artery (HP:0001195)5.09126358
8Abnormal hemoglobin (HP:0011902)4.89265407
9Hydroureter (HP:0000072)4.68300545
10Periauricular skin pits (HP:0100277)4.32587057
11Preauricular pit (HP:0004467)4.32587057
12Congenital malformation of the right heart (HP:0011723)4.30347373
13Double outlet right ventricle (HP:0001719)4.30347373
14Abnormal tarsal ossification (HP:0008369)4.19480863
15Abnormality of cochlea (HP:0000375)4.18273302
16Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.17862172
17Degeneration of the lateral corticospinal tracts (HP:0002314)4.17862172
18Bronchomalacia (HP:0002780)4.07092546
19Progressive inability to walk (HP:0002505)3.96913245
20Reduced antithrombin III activity (HP:0001976)3.95682341
21Urethral obstruction (HP:0000796)3.95078546
22Papillary thyroid carcinoma (HP:0002895)3.84486295
23Morphological abnormality of the middle ear (HP:0008609)3.72434803
24Glucose intolerance (HP:0000833)3.72401624
25Down-sloping shoulders (HP:0200021)3.59860692
26Renal tubular dysfunction (HP:0000124)3.52749236
27Aplasia/Hypoplasia of the scapulae (HP:0006713)3.50890965
28Hypoplastic scapulae (HP:0000882)3.50890965
29Abnormality of the umbilical cord (HP:0010881)3.49440685
30Thoracolumbar scoliosis (HP:0002944)3.48200428
31Hypoalphalipoproteinemia (HP:0003233)3.47947056
32Bifid scrotum (HP:0000048)3.43859670
33Facial diplegia (HP:0001349)3.36859015
34Dysphonia (HP:0001618)3.34317725
35Skin pits (HP:0100276)3.33098059
36Abnormal glucose tolerance (HP:0001952)3.32196007
37Hypoplastic pelvis (HP:0008839)3.14691196
38Abnormality of the anterior horn cell (HP:0006802)3.14180320
39Degeneration of anterior horn cells (HP:0002398)3.14180320
40Ulnar bowing (HP:0003031)3.10250739
41Abnormal foot bone ossification (HP:0010675)3.06983162
42Abnormality of the corticospinal tract (HP:0002492)3.06005578
43Hypoplasia of the capital femoral epiphysis (HP:0003090)3.04955145
44Testicular neoplasm (HP:0010788)3.02612392
45Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)3.00659218
46Small epiphyses (HP:0010585)3.00161531
47Renal dysplasia (HP:0000110)2.94497833
48Inability to walk (HP:0002540)2.91847336
49Morphological abnormality of the inner ear (HP:0011390)2.91778684
50Abnormal auditory evoked potentials (HP:0006958)2.91600036
51Cupped ear (HP:0000378)2.89082045
52Tarsal synostosis (HP:0008368)2.82652063
53Synostosis involving the elbow (HP:0003938)2.82408557
54Humeroradial synostosis (HP:0003041)2.82408557
55Abnormality of abdominal situs (HP:0011620)2.80870243
56Abdominal situs inversus (HP:0003363)2.80870243
57Labial hypoplasia (HP:0000066)2.80061141
58Septo-optic dysplasia (HP:0100842)2.77454015
59Vaginal fistula (HP:0004320)2.74002973
60Synostosis involving bones of the feet (HP:0009140)2.72796190
61Synostosis involving bones of the lower limbs (HP:0009138)2.72796190
62Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.70558634
63Flat acetabular roof (HP:0003180)2.69787654
64Abnormality of the renal collecting system (HP:0004742)2.69719585
65Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.61982646
66Abnormal ventriculo-arterial connection (HP:0011563)2.61706990
67Transposition of the great arteries (HP:0001669)2.61706990
68Abnormal connection of the cardiac segments (HP:0011545)2.61706990
69Nuclear cataract (HP:0100018)2.60891753
70Ureteral duplication (HP:0000073)2.60560726
71Hypolipoproteinemia (HP:0010981)2.60449009
72Progressive sensorineural hearing impairment (HP:0000408)2.58767687
73Generalized aminoaciduria (HP:0002909)2.55321389
74Abnormal biliary tract morphology (HP:0012440)2.54332673
75Pseudobulbar signs (HP:0002200)2.52908499
76Renal cortical cysts (HP:0000803)2.52622496
77Thyroid carcinoma (HP:0002890)2.50099483
78Pulmonary artery stenosis (HP:0004415)2.48876566
79Hypothermia (HP:0002045)2.47583317
80Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.46232667
81Abnormality of the fovea (HP:0000493)2.46033420
82Absent radius (HP:0003974)2.42286334
83Hypoplastic female external genitalia (HP:0012815)2.42196274
84Abnormality of the right ventricle (HP:0001707)2.41508801
85Pancreatic islet-cell hyperplasia (HP:0004510)2.37784561
86Sensory axonal neuropathy (HP:0003390)2.35571776
87Aplasia/hypoplasia of the humerus (HP:0006507)2.35369512
88Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.33514403
89Absent epiphyses (HP:0010577)2.33514403
90Cupped ribs (HP:0000887)2.32916526
91Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.32113165
92Fused cervical vertebrae (HP:0002949)2.29181613
93Prolonged partial thromboplastin time (HP:0003645)2.28190591
94Split foot (HP:0001839)2.27366809
95Abnormal pancreas size (HP:0012094)2.26484811
96Male pseudohermaphroditism (HP:0000037)2.25236821
97Aplasia involving bones of the extremities (HP:0009825)2.24998245
98Aplasia involving bones of the upper limbs (HP:0009823)2.24998245
99Aplasia of the phalanges of the hand (HP:0009802)2.24998245
100Abnormality of the phalanges of the 2nd finger (HP:0009541)2.24959759
101Abnormality of the phalanges of the 5th finger (HP:0004213)2.24319777
102Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.24188825
103Abnormality of alanine metabolism (HP:0010916)2.24188825
104Hyperalaninemia (HP:0003348)2.24188825
105Abnormal protein glycosylation (HP:0012346)2.23851088
106Abnormal glycosylation (HP:0012345)2.23851088
107Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.23851088
108Abnormal protein N-linked glycosylation (HP:0012347)2.23851088
109Scotoma (HP:0000575)2.22616573
110Choanal stenosis (HP:0000452)2.22305809
111Disproportionate short-trunk short stature (HP:0003521)2.22134607
112Myocardial infarction (HP:0001658)2.21598461
113Abolished electroretinogram (ERG) (HP:0000550)2.21017069
114Abnormalities of placenta or umbilical cord (HP:0001194)2.20369650
115Annular pancreas (HP:0001734)2.19578098
116Absent forearm bone (HP:0003953)2.19539948
117Aplasia involving forearm bones (HP:0009822)2.19539948
118Exertional dyspnea (HP:0002875)2.17514155
119Popliteal pterygium (HP:0009756)2.15920538
120Abnormality of the middle phalanges of the toes (HP:0010183)2.14330135
121Fair hair (HP:0002286)2.13636595
122Cerebral palsy (HP:0100021)2.09722471
123Tubulointerstitial nephritis (HP:0001970)2.07634419
124Abnormal sex determination (HP:0012244)2.07406546
125Sex reversal (HP:0012245)2.07406546
126Biliary tract neoplasm (HP:0100574)2.05164083
127Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.02479040
128Abnormality of the lumbar spine (HP:0100712)2.02386167
129Short humerus (HP:0005792)2.01854797
130Overgrowth (HP:0001548)2.01586906
131Polyuria (HP:0000103)2.01088501
132Short middle phalanx of the 5th finger (HP:0004220)1.98273705
133Hemivertebrae (HP:0002937)1.98085767
134Prenatal maternal abnormality (HP:0002686)1.97412787
135Central scotoma (HP:0000603)1.96011261
136Abnormality of the dental pulp (HP:0006479)1.95350484
137Abnormality of carpal bone ossification (HP:0006257)1.95088772
138Mixed hearing impairment (HP:0000410)1.95071822
139Abnormality of dentin (HP:0010299)1.94968125
140Chorioretinal atrophy (HP:0000533)1.94487872
141Bony spicule pigmentary retinopathy (HP:0007737)1.93991981
142Ankyloglossia (HP:0010296)1.92694603
143Type I transferrin isoform profile (HP:0003642)1.91665816
144Testicular atrophy (HP:0000029)1.90766026
145Abnormality of the labia (HP:0000058)1.90371561
146Abnormality of dental color (HP:0011073)1.90027252
147Attenuation of retinal blood vessels (HP:0007843)1.89936315
148Patent foramen ovale (HP:0001655)1.88727778
149Premature rupture of membranes (HP:0001788)1.88710594
150Hypercholesterolemia (HP:0003124)1.87561111
151Conjugated hyperbilirubinemia (HP:0002908)1.87130291
152Asplenia (HP:0001746)1.86788203
153Onycholysis (HP:0001806)1.86116897
154Delayed gross motor development (HP:0002194)1.84811508
155Asymmetry of the thorax (HP:0001555)1.84583879
156True hermaphroditism (HP:0010459)1.83392473
157Anophthalmia (HP:0000528)1.83364253
158Cutaneous finger syndactyly (HP:0010554)1.83260535
159Impaired pain sensation (HP:0007328)1.82848651
160Abnormality of pain sensation (HP:0010832)1.82848651
161Sleep apnea (HP:0010535)1.82686419
162Abnormality of the intrinsic pathway (HP:0010989)1.81908561
163Neoplasm of the adrenal cortex (HP:0100641)1.81554243
164Female pseudohermaphroditism (HP:0010458)1.81514889
165Generalized hypopigmentation of hair (HP:0011358)1.81385182
166Optic nerve hypoplasia (HP:0000609)1.79652885
167Clitoromegaly (HP:0000057)1.79605620
168Abnormality of the columella (HP:0009929)1.78627109
169Abnormality of the nasal septum (HP:0000419)1.78190861
170Polycythemia (HP:0001901)1.77297769
171Anencephaly (HP:0002323)1.75909152
172Dyschromatopsia (HP:0007641)1.74546449
173Accelerated skeletal maturation (HP:0005616)1.74144104
174Delayed CNS myelination (HP:0002188)1.74102758
175Glycosuria (HP:0003076)1.72711719
176Abnormality of urine glucose concentration (HP:0011016)1.72711719
177Right ventricular cardiomyopathy (HP:0011663)1.72109141
178Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.72009176
179Anal stenosis (HP:0002025)1.71307111
180Sprengel anomaly (HP:0000912)1.71265166
181Hypoplastic labia majora (HP:0000059)1.70953276
182Abnormal urine output (HP:0012590)1.68490729
183Intestinal atresia (HP:0011100)1.68148706
184Preauricular skin tag (HP:0000384)1.68111458
185Metaphyseal irregularity (HP:0003025)1.67749826
186Congenital, generalized hypertrichosis (HP:0004540)1.67494534
187Rectal prolapse (HP:0002035)1.67428518
188Osteomalacia (HP:0002749)1.67186319
189Palpitations (HP:0001962)1.66497993
190Nasolacrimal duct obstruction (HP:0000579)1.65251843
191Spastic diplegia (HP:0001264)1.64241704

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERBB34.03645174
2ERBB43.98663577
3ACVR1B3.96630328
4BMPR1B3.63543814
5ADRBK23.61941203
6TRIM283.57843785
7PINK13.51331025
8EIF2AK13.50070725
9MAP3K23.01995862
10TAOK23.01459344
11MAPK152.92915740
12EIF2AK32.71819086
13SIK32.68670844
14MAP3K32.57792914
15MAP3K122.56175132
16CAMK1D2.55178567
17BMPR22.54382405
18PBK2.53520807
19PAK32.52975756
20RIPK12.44781803
21CAMKK22.41347973
22RPS6KB22.38964509
23MAP2K12.34042638
24TAOK12.33036479
25MARK32.26226744
26MAP3K92.20134065
27MAP2K22.11062602
28NME22.07076811
29ZAK2.05120679
30STK102.02877101
31MAP3K111.95069725
32FER1.79366708
33MAP2K31.77589989
34CAMK1G1.71823272
35TRPM71.69888407
36PKN21.68566831
37TGFBR11.65488690
38HIPK21.63314202
39FRK1.63101171
40MST41.62743269
41BRSK21.54419495
42DAPK21.49862127
43PLK41.40595682
44TGFBR21.39936339
45CAMKK11.39408756
46CAMK2D1.32222927
47MKNK21.31307882
48MAP3K71.30109610
49FLT31.27952349
50CAMK41.27702232
51NEK61.27497658
52CSNK1A1L1.23828828
53MARK21.22752924
54CAMK2B1.20450373
55STK41.19346130
56MAP2K61.18704842
57SIK11.17648228
58STK391.11839032
59IRAK31.10891671
60RIPK41.09541202
61ARAF1.08810872
62MST1R1.06128994
63TNIK1.04827148
64TESK11.04187902
65MOS1.01405521
66LATS11.01129922
67PDGFRB1.00570457
68BCKDK1.00178496
69MAP3K130.99662993
70ILK0.99213501
71PRKCI0.97476134
72CSNK1G20.92726261
73PHKG20.92085216
74PHKG10.92085216
75GRK10.90251439
76CAMK10.88240099
77CAMK2G0.84196326
78PLK20.82016844
79NEK10.81112611
80NEK20.79688913
81BRSK10.79112261
82CDK60.79041312
83MAP2K70.78618286
84CSNK1G30.77344094
85PRKD10.77100111
86IRAK20.77078830
87MAP3K140.76473023
88STK38L0.75756878
89PRKCQ0.74898949
90PNCK0.74740195
91BCR0.73790217
92MELK0.73369239
93PIK3CA0.71960711
94WEE10.70767713
95OXSR10.68830398
96LRRK20.68243628
97CSNK1G10.66686276
98MAPK130.66545918
99ADRBK10.61148074
100EIF2AK20.60931679
101ROCK20.60469491
102EPHA20.60453422
103PAK10.58766620
104MET0.58529221
105CLK10.56268376
106TLK10.54880001
107ERBB20.54398902
108FGFR10.54064198
109MAP3K100.53870547
110LMTK20.53550744
111CAMK2A0.52128737
112MAP3K40.51883208
113CDK80.50928020
114NLK0.50723862
115PRKCE0.49357261
116TYRO30.47598680
117DAPK30.47487552
118ROCK10.47133005
119MAP3K50.46564067
120MAPK70.46318469
121PRPF4B0.46136631
122STK30.45512077
123CDK140.42089275
124BUB10.41994369
125MKNK10.41522672
126FGR0.40518811
127INSRR0.40074511
128MAP3K10.39445739
129LIMK10.38585475
130RPS6KA50.38498429
131OBSCN0.37462591
132PRKG20.36705624
133DAPK10.34856641
134WNK30.33534528
135LATS20.33378507
136MAP3K80.33325996
137WNK40.32475088
138ABL20.32085728
139MATK0.31323999
140PRKCG0.30729167
141CHUK0.29851691
142MYLK0.29700606
143BMX0.28596043
144PAK40.28205872
145MAPK30.28078890
146ABL10.27908250
147PRKG10.27507169
148NUAK10.26579766
149SIK20.25866836
150SGK20.25738709
151KSR10.24796149
152EPHB20.24218844
153PRKD30.24136643
154DDR20.23676862
155VRK20.23446048
156MAPKAPK30.23372630
157TEC0.23100381
158IGF1R0.22487539
159TNK20.21950680
160IKBKE0.21891186
161MAPKAPK20.21103148
162PLK10.21063844
163RPS6KA60.20600931
164HCK0.20586398
165MINK10.20519175
166CDK180.20456902
167INSR0.20253405
168PTK20.20165972
169IKBKB0.19978118
170EGFR0.19757598
171TIE10.19101091

Predicted pathways (KEGG)

RankGene SetZ-score
1Pentose and glucuronate interconversions_Homo sapiens_hsa000407.46934034
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000537.14262452
3Drug metabolism - cytochrome P450_Homo sapiens_hsa009824.11011086
4Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009804.02357403
5Proteasome_Homo sapiens_hsa030503.92339580
6Sulfur metabolism_Homo sapiens_hsa009203.77305556
7Steroid hormone biosynthesis_Homo sapiens_hsa001403.67045052
8Chemical carcinogenesis_Homo sapiens_hsa052043.40861709
9Drug metabolism - other enzymes_Homo sapiens_hsa009833.17901242
10Pyruvate metabolism_Homo sapiens_hsa006202.96945089
11Starch and sucrose metabolism_Homo sapiens_hsa005002.87266133
12Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.85486769
13Retinol metabolism_Homo sapiens_hsa008302.70047775
14Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.64811475
15Other types of O-glycan biosynthesis_Homo sapiens_hsa005142.59066009
16Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.32510912
17Glutathione metabolism_Homo sapiens_hsa004802.28053091
18Steroid biosynthesis_Homo sapiens_hsa001002.19794902
19Sulfur relay system_Homo sapiens_hsa041222.12348512
20Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.09480293
21Complement and coagulation cascades_Homo sapiens_hsa046102.08661200
22SNARE interactions in vesicular transport_Homo sapiens_hsa041302.07454051
23Fatty acid elongation_Homo sapiens_hsa000621.76753065
24Fatty acid metabolism_Homo sapiens_hsa012121.74515954
25Olfactory transduction_Homo sapiens_hsa047401.47366464
26Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.44726995
27Lysosome_Homo sapiens_hsa041421.43707785
28Basal transcription factors_Homo sapiens_hsa030221.39489288
29Wnt signaling pathway_Homo sapiens_hsa043101.37818873
30Caffeine metabolism_Homo sapiens_hsa002321.24079654
31Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.19671407
32N-Glycan biosynthesis_Homo sapiens_hsa005101.15563253
33Hedgehog signaling pathway_Homo sapiens_hsa043401.14576114
34alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.14521848
35Galactose metabolism_Homo sapiens_hsa000521.13550866
36Collecting duct acid secretion_Homo sapiens_hsa049661.11321832
37Protein export_Homo sapiens_hsa030601.08573917
38Nitrogen metabolism_Homo sapiens_hsa009101.05577047
39Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.04829695
40Vitamin digestion and absorption_Homo sapiens_hsa049771.00658297
41ABC transporters_Homo sapiens_hsa020100.96628259
42Tryptophan metabolism_Homo sapiens_hsa003800.95274110
43Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.91974751
44Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.85349612
45Cyanoamino acid metabolism_Homo sapiens_hsa004600.85141569
46Maturity onset diabetes of the young_Homo sapiens_hsa049500.84599103
47Fat digestion and absorption_Homo sapiens_hsa049750.81855106
48Gap junction_Homo sapiens_hsa045400.81485218
49Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.79937875
50Vibrio cholerae infection_Homo sapiens_hsa051100.75976726
51Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.74018439
52Primary bile acid biosynthesis_Homo sapiens_hsa001200.71185014
53Apoptosis_Homo sapiens_hsa042100.70829211
54Gastric acid secretion_Homo sapiens_hsa049710.69873606
55beta-Alanine metabolism_Homo sapiens_hsa004100.68613079
56Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.65162947
57Other glycan degradation_Homo sapiens_hsa005110.65031553
58Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.63350933
59Proteoglycans in cancer_Homo sapiens_hsa052050.58191878
60Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.57688359
61Regulation of actin cytoskeleton_Homo sapiens_hsa048100.56159421
62Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.55891962
63Thyroid hormone synthesis_Homo sapiens_hsa049180.52555267
64Mismatch repair_Homo sapiens_hsa034300.50140044
65* Metabolic pathways_Homo sapiens_hsa011000.47087743
66Histidine metabolism_Homo sapiens_hsa003400.46169784
67Peroxisome_Homo sapiens_hsa041460.46096739
68Platelet activation_Homo sapiens_hsa046110.46074631
69cGMP-PKG signaling pathway_Homo sapiens_hsa040220.45402276
70Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.44562947
71Sphingolipid metabolism_Homo sapiens_hsa006000.44496452
72Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.41631068
73Tight junction_Homo sapiens_hsa045300.40237336
74Cysteine and methionine metabolism_Homo sapiens_hsa002700.39796382
75Synaptic vesicle cycle_Homo sapiens_hsa047210.39227826
76Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.38846132
77Melanoma_Homo sapiens_hsa052180.37074822
78Non-homologous end-joining_Homo sapiens_hsa034500.36234131
79Basal cell carcinoma_Homo sapiens_hsa052170.35726372
80Rheumatoid arthritis_Homo sapiens_hsa053230.35418728
81Pyrimidine metabolism_Homo sapiens_hsa002400.35094932
82Selenocompound metabolism_Homo sapiens_hsa004500.34335533
83Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.34313880
84Axon guidance_Homo sapiens_hsa043600.33643391
85Circadian rhythm_Homo sapiens_hsa047100.33550479
86Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.33033793
87Central carbon metabolism in cancer_Homo sapiens_hsa052300.32592787
88Arachidonic acid metabolism_Homo sapiens_hsa005900.32084621
89Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.32027137
90Malaria_Homo sapiens_hsa051440.31598256
91Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.30611376
92Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.29690911
93Bile secretion_Homo sapiens_hsa049760.29612286
94Adherens junction_Homo sapiens_hsa045200.29590523
95Mineral absorption_Homo sapiens_hsa049780.29281728
96Oocyte meiosis_Homo sapiens_hsa041140.29213188
97Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.28909769
98Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.28298263
99Salivary secretion_Homo sapiens_hsa049700.28261337
100Fatty acid biosynthesis_Homo sapiens_hsa000610.28169729
101Prion diseases_Homo sapiens_hsa050200.27976355
102Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.26896644
103Vascular smooth muscle contraction_Homo sapiens_hsa042700.26415794
104Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.26270203
105Fatty acid degradation_Homo sapiens_hsa000710.25793202
106Staphylococcus aureus infection_Homo sapiens_hsa051500.25644187
107Purine metabolism_Homo sapiens_hsa002300.25365294
108* Butanoate metabolism_Homo sapiens_hsa006500.25311605
109Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.25136972
110Leukocyte transendothelial migration_Homo sapiens_hsa046700.25104245
111Glycerophospholipid metabolism_Homo sapiens_hsa005640.24056361
112mRNA surveillance pathway_Homo sapiens_hsa030150.23899000
113Notch signaling pathway_Homo sapiens_hsa043300.23779865
114ECM-receptor interaction_Homo sapiens_hsa045120.22978192
115Aldosterone synthesis and secretion_Homo sapiens_hsa049250.21393022
116Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.20289948
117Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.17808368
118Estrogen signaling pathway_Homo sapiens_hsa049150.17621480
119Fructose and mannose metabolism_Homo sapiens_hsa000510.17344819
120Renin secretion_Homo sapiens_hsa049240.16785984
121Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.16002292
122Glycerolipid metabolism_Homo sapiens_hsa005610.15619493
123Type II diabetes mellitus_Homo sapiens_hsa049300.14365796
124Glycosaminoglycan degradation_Homo sapiens_hsa005310.14044050
125GnRH signaling pathway_Homo sapiens_hsa049120.13695998
126TGF-beta signaling pathway_Homo sapiens_hsa043500.13336981
127Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.13168402
128Prolactin signaling pathway_Homo sapiens_hsa049170.13053545
129Amoebiasis_Homo sapiens_hsa051460.12083305
130Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.11782882
131AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.11066778
132Phenylalanine metabolism_Homo sapiens_hsa003600.10795421
133cAMP signaling pathway_Homo sapiens_hsa040240.10392310
134Circadian entrainment_Homo sapiens_hsa047130.09922308
135Cholinergic synapse_Homo sapiens_hsa047250.09918763
136PPAR signaling pathway_Homo sapiens_hsa033200.09603285
137Hippo signaling pathway_Homo sapiens_hsa043900.09159111
138TNF signaling pathway_Homo sapiens_hsa046680.08991791
139Phagosome_Homo sapiens_hsa041450.08248567
140Amphetamine addiction_Homo sapiens_hsa050310.07651900
141Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.07498136
142Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.07016527
143Cocaine addiction_Homo sapiens_hsa050300.06988214
144Folate biosynthesis_Homo sapiens_hsa007900.06890283
145Dilated cardiomyopathy_Homo sapiens_hsa054140.06336071
146Propanoate metabolism_Homo sapiens_hsa006400.06305501
147Dopaminergic synapse_Homo sapiens_hsa047280.06090827
148Morphine addiction_Homo sapiens_hsa050320.06023205
149Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.05949019
150Insulin secretion_Homo sapiens_hsa049110.04518778
151Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.04160260
152Hepatitis C_Homo sapiens_hsa051600.03132750
153Calcium signaling pathway_Homo sapiens_hsa040200.02504898
154FoxO signaling pathway_Homo sapiens_hsa040680.02401106
155Rap1 signaling pathway_Homo sapiens_hsa040150.02188597
156Taste transduction_Homo sapiens_hsa047420.01535530
157Insulin resistance_Homo sapiens_hsa049310.01510334
158Prostate cancer_Homo sapiens_hsa052150.01475584

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