ACSM5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1omega-hydroxylase P450 pathway (GO:0097267)8.36618179
2epoxygenase P450 pathway (GO:0019373)8.31057952
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.58625542
4L-phenylalanine catabolic process (GO:0006559)7.58625542
5L-phenylalanine metabolic process (GO:0006558)7.25378821
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.25378821
7aromatic amino acid family catabolic process (GO:0009074)6.91395373
8indole-containing compound catabolic process (GO:0042436)6.33788121
9indolalkylamine catabolic process (GO:0046218)6.33788121
10tryptophan catabolic process (GO:0006569)6.33788121
11kynurenine metabolic process (GO:0070189)6.14354478
12triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.02242813
13drug metabolic process (GO:0017144)6.01565921
14bile acid biosynthetic process (GO:0006699)5.98240019
15tryptophan metabolic process (GO:0006568)5.95732456
16glyoxylate metabolic process (GO:0046487)5.95087499
17oxidative demethylation (GO:0070989)5.89621652
18alpha-linolenic acid metabolic process (GO:0036109)5.56223398
19cysteine metabolic process (GO:0006534)5.54277567
20urea cycle (GO:0000050)5.53393480
21urea metabolic process (GO:0019627)5.53393480
22ethanol metabolic process (GO:0006067)5.35639642
23sulfur amino acid catabolic process (GO:0000098)5.33671743
24negative regulation of fibrinolysis (GO:0051918)5.31186754
25complement activation, alternative pathway (GO:0006957)5.24962365
26high-density lipoprotein particle remodeling (GO:0034375)5.22050019
27serine family amino acid catabolic process (GO:0009071)5.21239325
28protein carboxylation (GO:0018214)5.20246696
29peptidyl-glutamic acid carboxylation (GO:0017187)5.20246696
30regulation of protein activation cascade (GO:2000257)5.18437616
31regulation of fibrinolysis (GO:0051917)5.14051939
32nitrogen cycle metabolic process (GO:0071941)5.09818239
33bile acid metabolic process (GO:0008206)5.08750017
34regulation of plasminogen activation (GO:0010755)5.08504488
35fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.04144973
36aromatic amino acid family metabolic process (GO:0009072)5.02005043
37lysine metabolic process (GO:0006553)4.99811204
38lysine catabolic process (GO:0006554)4.99811204
39homocysteine metabolic process (GO:0050667)4.91695816
40phenylpropanoid metabolic process (GO:0009698)4.88177278
41regulation of complement activation (GO:0030449)4.86531259
42tyrosine metabolic process (GO:0006570)4.73087499
43negative regulation of blood coagulation (GO:0030195)4.72667535
44negative regulation of hemostasis (GO:1900047)4.72667535
45alpha-amino acid catabolic process (GO:1901606)4.72413178
46amino-acid betaine metabolic process (GO:0006577)4.70283458
47S-adenosylmethionine metabolic process (GO:0046500)4.69764116
48regulation of triglyceride catabolic process (GO:0010896)4.61559018
49reverse cholesterol transport (GO:0043691)4.55374003
50cellular ketone body metabolic process (GO:0046950)4.54748675
51regulation of cholesterol esterification (GO:0010872)4.53662636
52indolalkylamine metabolic process (GO:0006586)4.48560171
53plasma lipoprotein particle remodeling (GO:0034369)4.48510743
54protein-lipid complex remodeling (GO:0034368)4.48510743
55macromolecular complex remodeling (GO:0034367)4.48510743
56triglyceride homeostasis (GO:0070328)4.47657267
57acylglycerol homeostasis (GO:0055090)4.47657267
58negative regulation of cholesterol transport (GO:0032375)4.45882443
59negative regulation of sterol transport (GO:0032372)4.45882443
60coenzyme catabolic process (GO:0009109)4.44488528
61glycine metabolic process (GO:0006544)4.42205393
62cellular glucuronidation (GO:0052695)4.39479044
63amine catabolic process (GO:0009310)4.39254979
64cellular biogenic amine catabolic process (GO:0042402)4.39254979
65cellular amino acid catabolic process (GO:0009063)4.36776392
66acute-phase response (GO:0006953)4.36065748
67bile acid and bile salt transport (GO:0015721)4.35484023
68glutamate metabolic process (GO:0006536)4.35325133
69serine family amino acid metabolic process (GO:0009069)4.31191728
70negative regulation of coagulation (GO:0050819)4.29857586
71imidazole-containing compound metabolic process (GO:0052803)4.28889111
72phospholipid efflux (GO:0033700)4.27193038
73ethanol oxidation (GO:0006069)4.24390569
74fat-soluble vitamin biosynthetic process (GO:0042362)4.23737967
75regulation of humoral immune response (GO:0002920)4.21657137
76negative regulation of protein activation cascade (GO:2000258)4.20265350
77cellular modified amino acid catabolic process (GO:0042219)4.19625363
78negative regulation of wound healing (GO:0061045)4.19561790
79benzene-containing compound metabolic process (GO:0042537)4.19216258
80drug catabolic process (GO:0042737)4.15426058
81plasma lipoprotein particle clearance (GO:0034381)4.15341606
82alkaloid metabolic process (GO:0009820)4.12868552
83response to mercury ion (GO:0046689)4.11025497
84serine family amino acid biosynthetic process (GO:0009070)4.08060356
85dicarboxylic acid biosynthetic process (GO:0043650)4.05545531
86positive regulation of blood coagulation (GO:0030194)4.01427691
87positive regulation of hemostasis (GO:1900048)4.01427691
88aldehyde catabolic process (GO:0046185)3.99679642
89intestinal cholesterol absorption (GO:0030299)3.97585595
90cholesterol efflux (GO:0033344)3.96897833
91glucuronate metabolic process (GO:0019585)3.93736925
92uronic acid metabolic process (GO:0006063)3.93736925
93ketone body metabolic process (GO:1902224)3.93596349
94arginine metabolic process (GO:0006525)3.92896507
95opsonization (GO:0008228)3.92628070
96short-chain fatty acid metabolic process (GO:0046459)3.92019409
97disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.89430480
98killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.89430480
99acetyl-CoA metabolic process (GO:0006084)3.88364678
100urate metabolic process (GO:0046415)3.84285399
101low-density lipoprotein particle remodeling (GO:0034374)3.83773867
102regulation of bile acid biosynthetic process (GO:0070857)3.83171896
103carboxylic acid catabolic process (GO:0046395)3.82945075
104organic acid catabolic process (GO:0016054)3.82945075
105fibrinolysis (GO:0042730)3.82760999
106drug transmembrane transport (GO:0006855)3.81276715
107plasma lipoprotein particle assembly (GO:0034377)3.75804753
108flavonoid metabolic process (GO:0009812)3.75172883
109negative regulation of lipase activity (GO:0060192)3.74171379
110positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.74152992
111regulation of cholesterol homeostasis (GO:2000188)3.73516149
112cofactor catabolic process (GO:0051187)3.73021229
113hormone catabolic process (GO:0042447)3.71508948
114positive regulation of coagulation (GO:0050820)3.71335588
115complement activation, classical pathway (GO:0006958)3.67989809
116polyketide metabolic process (GO:0030638)3.67447161
117doxorubicin metabolic process (GO:0044598)3.67447161
118daunorubicin metabolic process (GO:0044597)3.67447161
119aspartate family amino acid catabolic process (GO:0009068)3.66987449
120phospholipid homeostasis (GO:0055091)3.66881186
121exogenous drug catabolic process (GO:0042738)3.66742246
122cytolysis (GO:0019835)3.65464369
123cholesterol homeostasis (GO:0042632)3.65046245
124complement activation (GO:0006956)3.64316339
125blood coagulation, intrinsic pathway (GO:0007597)3.63287926
126positive regulation of lipid catabolic process (GO:0050996)3.60976817
127sterol homeostasis (GO:0055092)3.60020991
1282-oxoglutarate metabolic process (GO:0006103)3.58781450
129protein activation cascade (GO:0072376)3.58631408
130positive regulation of lipoprotein lipase activity (GO:0051006)3.58330650
131positive regulation of triglyceride lipase activity (GO:0061365)3.58330650
132very-low-density lipoprotein particle assembly (GO:0034379)3.58213875
133heme transport (GO:0015886)3.55050596
134primary alcohol catabolic process (GO:0034310)3.53561806
135xenobiotic metabolic process (GO:0006805)3.48731024
136sodium-independent organic anion transport (GO:0043252)3.46306068
137negative regulation of complement activation (GO:0045916)3.39636891

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.34610592
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse7.14562030
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.92925396
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.46301434
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.23229717
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.91323096
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.91220312
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.03504841
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.90448026
10TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.08409418
11TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.06070918
12HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.01144867
13ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.8137172
14FOXA2_19822575_ChIP-Seq_HepG2_Human1.62374443
15CLOCK_20551151_ChIP-Seq_293T_Human1.58018523
16HTT_18923047_ChIP-ChIP_STHdh_Human1.52349822
17* HNF4A_19822575_ChIP-Seq_HepG2_Human1.42400288
18GATA1_22025678_ChIP-Seq_K562_Human1.36453315
19THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.22209521
20STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.21389140
21RXRA_24833708_ChIP-Seq_LIVER_Mouse1.17701365
22MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.15380993
23TRIM28_21343339_ChIP-Seq_HEK293_Human1.09380093
24IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.05634014
25PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.04962784
26ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.04697859
27STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.04695421
28SOX2_27498859_Chip-Seq_STOMACH_Mouse0.96213673
29ESR1_15608294_ChIP-ChIP_MCF-7_Human0.95247795
30TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.94084944
31RARG_19884340_ChIP-ChIP_MEFs_Mouse0.90418791
32BP1_19119308_ChIP-ChIP_Hs578T_Human0.89820115
33ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.89249052
34PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.88173663
35CDX2_19796622_ChIP-Seq_MESCs_Mouse0.86676786
36GATA4_25053715_ChIP-Seq_YYC3_Human0.84727971
37AUTS2_25519132_ChIP-Seq_293T-REX_Human0.83815933
38ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.81862204
39HNFA_21074721_ChIP-Seq_CACO-2_Human0.80685654
40IRF8_22096565_ChIP-ChIP_GC-B_Human0.79861442
41BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.78405774
42CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.78261349
43KAP1_22055183_ChIP-Seq_ESCs_Mouse0.78135688
44Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.74985547
45SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.74541815
46ESR2_21235772_ChIP-Seq_MCF-7_Human0.73767839
47PIAS1_25552417_ChIP-Seq_VCAP_Human0.73096449
48PHF8_20622853_ChIP-Seq_HELA_Human0.73092012
49SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.71741318
50CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.71739241
51AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.71302474
52RARA_24833708_ChIP-Seq_LIVER_Mouse0.70976249
53SOX2_21211035_ChIP-Seq_LN229_Human0.70677547
54TP53_18474530_ChIP-ChIP_U2OS_Human0.70354248
55ZNF263_19887448_ChIP-Seq_K562_Human0.68804926
56SALL4_18804426_ChIP-ChIP_XEN_Mouse0.68599849
57NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.68473273
58NRF2_20460467_ChIP-Seq_MEFs_Mouse0.68473273
59ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.66195323
60RAC3_21632823_ChIP-Seq_H3396_Human0.65038159
61RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.64407441
62SPI1_20517297_ChIP-Seq_HL60_Human0.64084234
63NFYA_21822215_ChIP-Seq_K562_Human0.63864403
64NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.63583153
65GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.63408748
66RAD21_21589869_ChIP-Seq_MESCs_Mouse0.63262804
67NFE2_27457419_Chip-Seq_LIVER_Mouse0.62072637
68FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.61951685
69DNAJC2_21179169_ChIP-ChIP_NT2_Human0.61354230
70BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.61204522
71RARB_24833708_ChIP-Seq_LIVER_Mouse0.60674148
72PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.60633871
73NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.59430379
74CEBPB_22108803_ChIP-Seq_LS180_Human0.58683241
75KLF5_20875108_ChIP-Seq_MESCs_Mouse0.58573602
76ER_23166858_ChIP-Seq_MCF-7_Human0.58078972
77GATA6_21074721_ChIP-Seq_CACO-2_Human0.58053712
78SMC4_20622854_ChIP-Seq_HELA_Human0.57855389
79EZH2_27294783_Chip-Seq_NPCs_Mouse0.57540080
80ESR1_21235772_ChIP-Seq_MCF-7_Human0.56939607
81IGF1R_20145208_ChIP-Seq_DFB_Human0.56842532
82EGR1_19032775_ChIP-ChIP_M12_Human0.56079008
83LXR_22292898_ChIP-Seq_THP-1_Human0.55339315
84CDX2_20551321_ChIP-Seq_CACO-2_Human0.54528666
85STAT3_1855785_ChIP-Seq_MESCs_Mouse0.53939187
86SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.53546698
87MYC_19915707_ChIP-ChIP_AK7_Human0.53533669
88FOXA1_25552417_ChIP-Seq_VCAP_Human0.53404497
89SOX2_20726797_ChIP-Seq_SW620_Human0.53321705
90ETV2_25802403_ChIP-Seq_MESCs_Mouse0.53087093
91FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.53082477
92CRX_20693478_ChIP-Seq_RETINA_Mouse0.52889516
93CBX2_22325352_ChIP-Seq_293T-Rex_Human0.52821956
94AR_20517297_ChIP-Seq_VCAP_Human0.52681110
95PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.52530295
96GATA2_21666600_ChIP-Seq_HMVEC_Human0.52037898
97* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.51595920
98ESET_19884257_ChIP-Seq_ESCs_Mouse0.51438749
99GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.51211430
100STAT1_17558387_ChIP-Seq_HELA_Human0.50932883
101CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.50713578
102CBP_21632823_ChIP-Seq_H3396_Human0.50671546
103MYC_19829295_ChIP-Seq_ESCs_Human0.49895516
104FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.48976192
105TAF15_26573619_Chip-Seq_HEK293_Human0.48082104
106PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.47461199
107FOXO3_23340844_ChIP-Seq_DLD1_Human0.47404801
108NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.46836672
109E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.46390156
110P53_21459846_ChIP-Seq_SAOS-2_Human0.45010899
111GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.44360317
112PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.43378151
113ESR1_20079471_ChIP-ChIP_T-47D_Human0.43332579
114BCAT_22108803_ChIP-Seq_LS180_Human0.43147847
115PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.43126200
116TAF2_19829295_ChIP-Seq_ESCs_Human0.42961337
117PPAR_26484153_Chip-Seq_NCI-H1993_Human0.42937784
118CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.42311173
119GATA6_25053715_ChIP-Seq_YYC3_Human0.42000709
120FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.41823638
121ERG_21242973_ChIP-ChIP_JURKAT_Human0.41686484
122SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.40883348
123GATA1_19941826_ChIP-Seq_K562_Human0.40725983
124GATA1_19941827_ChIP-Seq_MEL_Mouse0.40517671
125GATA2_19941826_ChIP-Seq_K562_Human0.40190838
126STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.38783166
127FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.38687369
128SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.38268733
129MYC_27129775_Chip-Seq_CORNEA_Mouse0.36981136
130CDX2_22108803_ChIP-Seq_LS180_Human0.36497610
131EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.36263054
132ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.36235972
133LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.35594242
134CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.34999992
135FOXH1_21741376_ChIP-Seq_EPCs_Human0.34782280

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.31137312
2MP0005360_urolithiasis7.77455506
3MP0005085_abnormal_gallbladder_physiolo6.36552934
4MP0005365_abnormal_bile_salt6.06152305
5MP0008875_abnormal_xenobiotic_pharmacok5.14006760
6MP0003806_abnormal_nucleotide_metabolis4.20456541
7MP0003252_abnormal_bile_duct3.94316596
8MP0010329_abnormal_lipoprotein_level3.48897245
9MP0009840_abnormal_foam_cell3.07599080
10MP0003195_calcinosis2.98564164
11MP0005083_abnormal_biliary_tract2.98419409
12MP0005332_abnormal_amino_acid2.94630133
13MP0001666_abnormal_nutrient_absorption2.55903604
14MP0004019_abnormal_vitamin_homeostasis2.34800060
15MP0003191_abnormal_cellular_cholesterol2.17563283
16MP0000609_abnormal_liver_physiology2.11507538
17MP0002118_abnormal_lipid_homeostasis2.08431089
18MP0002138_abnormal_hepatobiliary_system2.06397144
19MP0005319_abnormal_enzyme/_coenzyme1.84995664
20MP0003868_abnormal_feces_composition1.83254120
21MP0001764_abnormal_homeostasis1.66034213
22MP0005584_abnormal_enzyme/coenzyme_acti1.60223424
23MP0009697_abnormal_copulation1.49096040
24MP0005451_abnormal_body_composition1.42247022
25MP0009643_abnormal_urine_homeostasis1.40662063
26MP0003186_abnormal_redox_activity1.31905858
27MP0003011_delayed_dark_adaptation1.24289330
28MP0000598_abnormal_liver_morphology1.14958261
29MP0003656_abnormal_erythrocyte_physiolo1.14069558
30MP0005647_abnormal_sex_gland1.13774972
31MP0003705_abnormal_hypodermis_morpholog1.09029945
32MP0002132_abnormal_respiratory_system1.06436514
33MP0009764_decreased_sensitivity_to1.05778833
34MP0005636_abnormal_mineral_homeostasis1.04829726
35MP0000604_amyloidosis1.01251844
36MP0002254_reproductive_system_inflammat0.99218787
37MP0009763_increased_sensitivity_to0.97505070
38MP0010368_abnormal_lymphatic_system0.88361441
39MP0006036_abnormal_mitochondrial_physio0.88356095
40MP0008469_abnormal_protein_level0.87260704
41MP0005670_abnormal_white_adipose0.87169684
42MP0009642_abnormal_blood_homeostasis0.87125500
43MP0003879_abnormal_hair_cell0.86902181
44MP0005084_abnormal_gallbladder_morpholo0.85266167
45MP0002876_abnormal_thyroid_physiology0.84958430
46MP0005408_hypopigmentation0.82239448
47MP0002078_abnormal_glucose_homeostasis0.78271554
48MP0005376_homeostasis/metabolism_phenot0.77050923
49MP0009765_abnormal_xenobiotic_induced0.75303415
50MP0002971_abnormal_brown_adipose0.74413629
51MP0001915_intracranial_hemorrhage0.74076822
52MP0005535_abnormal_body_temperature0.73561476
53MP0005220_abnormal_exocrine_pancreas0.73502069
54MP0004130_abnormal_muscle_cell0.73395479
55MP0001756_abnormal_urination0.72931809
56MP0001661_extended_life_span0.71981978
57MP0005334_abnormal_fat_pad0.69316001
58MP0003690_abnormal_glial_cell0.67675944
59MP0003646_muscle_fatigue0.65523925
60MP0005266_abnormal_metabolism0.63717043
61MP0003329_amyloid_beta_deposits0.63564903
62MP0002332_abnormal_exercise_endurance0.62354846
63MP0006035_abnormal_mitochondrial_morpho0.59955780
64MP0002136_abnormal_kidney_physiology0.59870853
65MP0009053_abnormal_anal_canal0.58059314
66MP0005187_abnormal_penis_morphology0.57410100
67MP0005375_adipose_tissue_phenotype0.55803789
68MP0003959_abnormal_lean_body0.54375750
69MP0002928_abnormal_bile_duct0.53664587
70MP0005023_abnormal_wound_healing0.53160302
71MP0005448_abnormal_energy_balance0.52888878
72MP0000639_abnormal_adrenal_gland0.52804838
73MP0009785_altered_susceptibility_to0.52563420
74MP0004043_abnormal_pH_regulation0.51501247
75MP0003638_abnormal_response/metabolism_0.49507215
76MP0002282_abnormal_trachea_morphology0.49456341
77MP0005395_other_phenotype0.48699627
78MP0005164_abnormal_response_to0.47440171
79MP0002822_catalepsy0.46536999
80MP0002837_dystrophic_cardiac_calcinosis0.46230603
81MP0005666_abnormal_adipose_tissue0.45793203
82MP0008874_decreased_physiological_sensi0.45346184
83MP0002249_abnormal_larynx_morphology0.44130945
84MP0003724_increased_susceptibility_to0.43896213
85MP0005464_abnormal_platelet_physiology0.43328250
86MP0005167_abnormal_blood-brain_barrier0.42916514
87MP0003953_abnormal_hormone_level0.42296453
88MP0004782_abnormal_surfactant_physiolog0.42004934
89MP0003718_maternal_effect0.41937735
90MP0008873_increased_physiological_sensi0.40681453
91MP0003075_altered_response_to0.39265406
92MP0005166_decreased_susceptibility_to0.38730161
93MP0002269_muscular_atrophy0.38133265
94MP0000230_abnormal_systemic_arterial0.38109566
95MP0009672_abnormal_birth_weight0.37846947
96MP0003436_decreased_susceptibility_to0.36530854
97MP0008872_abnormal_physiological_respon0.36465972
98MP0002168_other_aberrant_phenotype0.36464699
99MP0001765_abnormal_ion_homeostasis0.35780826
100MP0005248_abnormal_Harderian_gland0.35702572
101MP0004381_abnormal_hair_follicle0.35575566
102MP0002796_impaired_skin_barrier0.35081592
103MP0009115_abnormal_fat_cell0.34397899
104MP0005330_cardiomyopathy0.33961464
105MP0000579_abnormal_nail_morphology0.33404754
106MP0000749_muscle_degeneration0.33380290
107MP0005058_abnormal_lysosome_morphology0.32623647
108MP0009384_cardiac_valve_regurgitation0.32434863
109MP0006082_CNS_inflammation0.30754827
110MP0004036_abnormal_muscle_relaxation0.30592298
111MP0002970_abnormal_white_adipose0.30464811
112MP0000249_abnormal_blood_vessel0.28305675
113MP0001853_heart_inflammation0.28123970
114MP0000751_myopathy0.26491491
115MP0006138_congestive_heart_failure0.26229140
116MP0001845_abnormal_inflammatory_respons0.26141570
117MP0004087_abnormal_muscle_fiber0.25939856
118MP0001881_abnormal_mammary_gland0.25921779
119MP0002135_abnormal_kidney_morphology0.25588256
120MP0001243_abnormal_dermal_layer0.25358537
121MP0003633_abnormal_nervous_system0.24639007
122MP0000920_abnormal_myelination0.24532375
123MP0001851_eye_inflammation0.23083785
124MP0004883_abnormal_blood_vessel0.22903602
125MP0002128_abnormal_blood_circulation0.22867461
126MP0000747_muscle_weakness0.22500454
127MP0005397_hematopoietic_system_phenotyp0.21967911
128MP0001545_abnormal_hematopoietic_system0.21967911
129MP0005452_abnormal_adipose_tissue0.21358403

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.28609606
2Intrahepatic cholestasis (HP:0001406)7.22232662
3Deep venous thrombosis (HP:0002625)7.10183409
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.46714879
5Prolonged partial thromboplastin time (HP:0003645)6.27142956
6Xanthomatosis (HP:0000991)6.14504099
7Hypobetalipoproteinemia (HP:0003563)6.11155749
8Hyperlipoproteinemia (HP:0010980)5.32197360
9Complement deficiency (HP:0004431)5.28353263
10Hyperammonemia (HP:0001987)4.65120023
11Hyperglycinemia (HP:0002154)4.61032156
12Joint hemorrhage (HP:0005261)4.60752029
13Hypolipoproteinemia (HP:0010981)4.55150272
14Ketosis (HP:0001946)4.42134992
15Abnormality of glutamine family amino acid metabolism (HP:0010902)4.41702873
16Epidermoid cyst (HP:0200040)4.40365153
17Hyperglycinuria (HP:0003108)4.30381880
18Abnormality of sulfur amino acid metabolism (HP:0004339)4.24352991
19Abnormality of glycine metabolism (HP:0010895)4.21878514
20Abnormality of serine family amino acid metabolism (HP:0010894)4.21878514
21Abnormality of the common coagulation pathway (HP:0010990)4.20214041
22Abnormality of aspartate family amino acid metabolism (HP:0010899)4.17887877
23Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.16586050
24Fat malabsorption (HP:0002630)4.08749882
25Abnormality of methionine metabolism (HP:0010901)4.08457051
26Hypoalphalipoproteinemia (HP:0003233)3.96465668
27Nephritis (HP:0000123)3.88790147
28Hypoglycemic coma (HP:0001325)3.83227067
29Abnormality of complement system (HP:0005339)3.82786058
30Conjugated hyperbilirubinemia (HP:0002908)3.72896053
31Abnormality of pyrimidine metabolism (HP:0004353)3.72412070
32Abnormality of the intrinsic pathway (HP:0010989)3.58843482
33Hypercholesterolemia (HP:0003124)3.50665324
34Abnormality of fatty-acid metabolism (HP:0004359)3.49203468
35Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.35110218
36Delayed CNS myelination (HP:0002188)3.30187784
37Ketoacidosis (HP:0001993)3.28995592
38Hyperbilirubinemia (HP:0002904)3.28551991
39Abnormality of nucleobase metabolism (HP:0010932)3.22662525
40Abnormality of serum amino acid levels (HP:0003112)3.14613912
41Steatorrhea (HP:0002570)3.08346137
42Abnormality of purine metabolism (HP:0004352)2.97787752
43Hepatocellular carcinoma (HP:0001402)2.95097275
44Gout (HP:0001997)2.94179421
45Myocardial infarction (HP:0001658)2.91342621
46Metabolic acidosis (HP:0001942)2.86442813
47Hypochromic microcytic anemia (HP:0004840)2.78860253
48Spontaneous abortion (HP:0005268)2.76731646
49Vascular calcification (HP:0004934)2.76066308
50Abnormality of dicarboxylic acid metabolism (HP:0010995)2.72577432
51Dicarboxylic aciduria (HP:0003215)2.72577432
52Skin nodule (HP:0200036)2.72244860
53Systemic lupus erythematosus (HP:0002725)2.70715210
54Lethargy (HP:0001254)2.69237914
55Purpura (HP:0000979)2.50419791
56Spastic diplegia (HP:0001264)2.48097438
57Osteomalacia (HP:0002749)2.47530157
58Cardiovascular calcification (HP:0011915)2.44819083
59Cerebral edema (HP:0002181)2.44769737
60Hypoglycemic seizures (HP:0002173)2.41717477
61Neonatal onset (HP:0003623)2.41290569
62Mitral stenosis (HP:0001718)2.41125226
63Irritability (HP:0000737)2.40465420
64Acanthocytosis (HP:0001927)2.39602324
65Abnormal gallbladder morphology (HP:0012437)2.38276721
66Malnutrition (HP:0004395)2.37411219
67Generalized aminoaciduria (HP:0002909)2.33538396
68Neonatal hypoglycemia (HP:0001998)2.33453585
69Reduced antithrombin III activity (HP:0001976)2.33351524
70Cholelithiasis (HP:0001081)2.32416298
71Glomerulonephritis (HP:0000099)2.32005239
72Recurrent gram-negative bacterial infections (HP:0005420)2.29983273
73Fair hair (HP:0002286)2.29390041
74Pulmonary embolism (HP:0002204)2.27379632
75Abnormal gallbladder physiology (HP:0012438)2.22447783
76Cholecystitis (HP:0001082)2.22447783
77Sensorimotor neuropathy (HP:0007141)2.22217503
78Enlarged kidneys (HP:0000105)2.20263099
79Late onset (HP:0003584)2.19553022
80Vomiting (HP:0002013)2.19167611
81Pancreatitis (HP:0001733)2.14927027
82Alkalosis (HP:0001948)2.13852081
83Esophageal varix (HP:0002040)2.13461950
84Rickets (HP:0002748)2.10404051
85Abnormality of vitamin metabolism (HP:0100508)2.10363192
86Hydroxyprolinuria (HP:0003080)2.10264804
87Abnormality of proline metabolism (HP:0010907)2.10264804
88Proximal tubulopathy (HP:0000114)2.09634320
89Brushfield spots (HP:0001088)2.09169144
90Amyloidosis (HP:0011034)2.06525514
91Opisthotonus (HP:0002179)2.03505942
92Menorrhagia (HP:0000132)2.03488142
93Increased purine levels (HP:0004368)2.02237634
94Hyperuricemia (HP:0002149)2.02237634
95Hyperphosphaturia (HP:0003109)2.01501882
96Gingival bleeding (HP:0000225)1.99065286
97Hemorrhage of the eye (HP:0011885)1.98097446
98Thrombophlebitis (HP:0004418)1.98032622
99Abnormality of the gallbladder (HP:0005264)1.96600528
100Hyperinsulinemic hypoglycemia (HP:0000825)1.96142102
101Abnormal enzyme/coenzyme activity (HP:0012379)1.95202328
102Hypophosphatemic rickets (HP:0004912)1.94461613
103Abnormality of urine glucose concentration (HP:0011016)1.89752368
104Glycosuria (HP:0003076)1.89752368
105Abnormal cartilage morphology (HP:0002763)1.88595046
106Increased mean platelet volume (HP:0011877)1.86932845
107Poikilocytosis (HP:0004447)1.86755088
108Renal cortical cysts (HP:0000803)1.86574310
109Bifid scrotum (HP:0000048)1.84485683
110Abnormality of the Achilles tendon (HP:0005109)1.83344313
111Joint swelling (HP:0001386)1.82313030
112Status epilepticus (HP:0002133)1.81995916
113Arthropathy (HP:0003040)1.81148815
114Elevated hepatic transaminases (HP:0002910)1.80092418
115Atrioventricular block (HP:0001678)1.75964164
116Elevated alkaline phosphatase (HP:0003155)1.74641308
117Increased serum ferritin (HP:0003281)1.73526485
118Abnormality of iron homeostasis (HP:0011031)1.70961952
119Cerebral palsy (HP:0100021)1.70400882
120Abnormal platelet volume (HP:0011876)1.67484434
121Abnormal platelet function (HP:0011869)1.65168367
122Impaired platelet aggregation (HP:0003540)1.65168367
123Hypertriglyceridemia (HP:0002155)1.64215611
124Epistaxis (HP:0000421)1.62943785
125Back pain (HP:0003418)1.61607469
126Gangrene (HP:0100758)1.60799274
127Abnormal urine phosphate concentration (HP:0012599)1.59093443
128Retinal atrophy (HP:0001105)1.56781921
129Abnormality of alkaline phosphatase activity (HP:0004379)1.55227630
130Abnormality of transition element cation homeostasis (HP:0011030)1.55210880

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.24146036
2SIK14.56372628
3FGFR44.53570957
4ERN14.14177199
5OBSCN3.22847338
6INSRR3.01798807
7TAOK32.97588758
8ERBB42.88437242
9MAP2K42.25603226
10MST1R2.20616394
11PKN22.06029070
12PIK3CA1.88254832
13MAPK111.87386912
14FLT31.74601317
15TRIB31.73712837
16PIK3CG1.72045191
17PRPF4B1.61039517
18LATS11.59870252
19TYK21.58573497
20ABL21.46411661
21NTRK31.46139968
22PTK61.44048886
23DAPK21.42384013
24MYLK1.39393442
25PHKG21.37397654
26PHKG11.37397654
27FGFR21.36210027
28FRK1.35247458
29NEK91.34062735
30MAP3K71.31318890
31PINK11.25563875
32KDR1.25042559
33NLK1.24099877
34STK38L1.21714813
35JAK21.19371859
36PRKAA21.19307361
37PDK21.18667994
38MAP3K11.13968549
39CAMKK21.10635299
40GRK61.09520123
41MAP3K141.05324416
42PRKG11.01632589
43MAP2K31.01016003
44JAK10.98485177
45ERBB20.97413551
46TNK20.96310614
47TBK10.95133106
48MAPK40.94063989
49PRKCZ0.93826769
50MAPKAPK30.92180170
51MAP3K100.89897214
52TIE10.87555891
53WNK30.87267150
54MOS0.86805782
55MAPK150.85447159
56EPHB10.84257273
57MET0.83112171
58MAP3K30.81156602
59MAPK120.80789394
60SGK30.77451515
61CAMK1D0.77451467
62TTN0.76394533
63KSR20.76100864
64CDK60.75607801
65WNK40.75532330
66PRKACG0.75302271
67PRKAA10.74363433
68IRAK30.73814868
69PRKACA0.73565196
70DYRK1B0.73166697
71GSK3A0.72436338
72ARAF0.69422274
73MAP3K110.67385387
74TRPM70.67331524
75MAP3K20.66585310
76CSK0.65925132
77RIPK10.65609263
78CAMK2G0.65192927
79MAP2K60.64949617
80FER0.64067017
81PDGFRA0.62589739
82SGK20.62376086
83EPHA30.60923226
84TGFBR20.59258166
85BLK0.59140632
86ZAP700.58624883
87PDK40.58437870
88PDK30.58437870
89EPHA40.58304621
90SGK2230.57875623
91SGK4940.57875623
92PTK20.56402222
93LATS20.55680139
94OXSR10.55132174
95PDPK10.54659172
96FGFR30.54591027
97MAPK70.53347081
98RPS6KA30.53270598
99PRKCQ0.50326837
100SGK10.48924692
101MARK30.48889906
102PRKACB0.48882420
103CSF1R0.47882108
104DDR20.47837348
105MAP3K130.46443615
106IKBKE0.45865626
107MUSK0.45410385
108CSNK1G10.44601599
109IGF1R0.43690725
110GRK10.42521657
111AKT20.41055549
112RPS6KB10.40752302
113CSNK1D0.39860815
114PKN10.39020441
115MAP3K50.38965314
116CDC42BPA0.38622344
117TAOK20.38558220
118PRKCG0.38244704
119RET0.36387061
120MAP2K10.36057629
121CDK40.35709944
122CAMK1G0.35641476
123IRAK20.35561255
124CAMK40.33611155
125PDK10.33544092
126MTOR0.33093839
127MAP3K60.32949234
128IRAK10.31745500
129ICK0.30567832
130EGFR0.30201618
131PAK30.26977256
132PRKCA0.26964781
133PBK0.26444248
134CSNK1G20.22537632
135STK380.22158207
136ABL10.20831555

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.44724855
2Nitrogen metabolism_Homo sapiens_hsa009103.48212712
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.41927813
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.29211170
5Arginine biosynthesis_Homo sapiens_hsa002202.97918924
6Tryptophan metabolism_Homo sapiens_hsa003802.73112784
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.70678692
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.66804507
9Complement and coagulation cascades_Homo sapiens_hsa046102.62250796
10Fatty acid degradation_Homo sapiens_hsa000712.53858207
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.52389971
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.49036750
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.34631677
14Peroxisome_Homo sapiens_hsa041462.14102996
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.11955158
16* Butanoate metabolism_Homo sapiens_hsa006502.07953356
17Propanoate metabolism_Homo sapiens_hsa006402.05479503
18Steroid hormone biosynthesis_Homo sapiens_hsa001401.92880283
19Chemical carcinogenesis_Homo sapiens_hsa052041.91214220
20Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.89230706
21Histidine metabolism_Homo sapiens_hsa003401.88986224
22PPAR signaling pathway_Homo sapiens_hsa033201.86748836
23Fatty acid metabolism_Homo sapiens_hsa012121.84157026
24beta-Alanine metabolism_Homo sapiens_hsa004101.76194644
25Drug metabolism - other enzymes_Homo sapiens_hsa009831.75318940
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.71693867
27Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.70450292
28Retinol metabolism_Homo sapiens_hsa008301.70144366
29Caffeine metabolism_Homo sapiens_hsa002321.69246215
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.67366298
31Staphylococcus aureus infection_Homo sapiens_hsa051501.65595374
322-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.62155943
33Selenocompound metabolism_Homo sapiens_hsa004501.56561416
34Bile secretion_Homo sapiens_hsa049761.53807448
35Phenylalanine metabolism_Homo sapiens_hsa003601.53538573
36Pyruvate metabolism_Homo sapiens_hsa006201.44413997
37Tyrosine metabolism_Homo sapiens_hsa003501.41229443
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.40355372
39Sulfur metabolism_Homo sapiens_hsa009201.37722139
40Starch and sucrose metabolism_Homo sapiens_hsa005001.31439673
41Fatty acid elongation_Homo sapiens_hsa000621.30189715
42Cysteine and methionine metabolism_Homo sapiens_hsa002701.26547237
43Folate biosynthesis_Homo sapiens_hsa007901.19433015
44ABC transporters_Homo sapiens_hsa020101.19229354
45Biosynthesis of amino acids_Homo sapiens_hsa012301.18973385
46Carbon metabolism_Homo sapiens_hsa012001.17218244
47Steroid biosynthesis_Homo sapiens_hsa001001.16120561
48Cyanoamino acid metabolism_Homo sapiens_hsa004601.14517874
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.10611863
50Fat digestion and absorption_Homo sapiens_hsa049751.09211860
51Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.00256739
52Maturity onset diabetes of the young_Homo sapiens_hsa049500.99843081
53Arginine and proline metabolism_Homo sapiens_hsa003300.98771235
54Vitamin B6 metabolism_Homo sapiens_hsa007500.95494275
55Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.94691389
56Sulfur relay system_Homo sapiens_hsa041220.91385081
57Vitamin digestion and absorption_Homo sapiens_hsa049770.90929964
58Lysine degradation_Homo sapiens_hsa003100.85969953
59Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.85133678
60One carbon pool by folate_Homo sapiens_hsa006700.73076275
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.72964480
62Glycerolipid metabolism_Homo sapiens_hsa005610.70823171
63Glutathione metabolism_Homo sapiens_hsa004800.69354111
64Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.62041228
65Pentose phosphate pathway_Homo sapiens_hsa000300.55676538
66Fatty acid biosynthesis_Homo sapiens_hsa000610.53626520
67* Metabolic pathways_Homo sapiens_hsa011000.46372251
68Pertussis_Homo sapiens_hsa051330.38338574
69Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.35709723
70Prion diseases_Homo sapiens_hsa050200.33744611
71Fructose and mannose metabolism_Homo sapiens_hsa000510.26046955
72alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.24400237
73Galactose metabolism_Homo sapiens_hsa000520.24321126
74Insulin resistance_Homo sapiens_hsa049310.23501001
75Adipocytokine signaling pathway_Homo sapiens_hsa049200.22923216
76Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.19248251
77Linoleic acid metabolism_Homo sapiens_hsa005910.18580099
78Glycerophospholipid metabolism_Homo sapiens_hsa005640.13874781
79Glucagon signaling pathway_Homo sapiens_hsa049220.09632527
80Other glycan degradation_Homo sapiens_hsa005110.08621345
81AMPK signaling pathway_Homo sapiens_hsa041520.02771948
82FoxO signaling pathway_Homo sapiens_hsa04068-0.2515095
83Mineral absorption_Homo sapiens_hsa04978-0.2331569
84Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.2330136
85Protein digestion and absorption_Homo sapiens_hsa04974-0.2313246
86Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.2306854
87Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.2284878
88Sphingolipid metabolism_Homo sapiens_hsa00600-0.2212692
89Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.2117395
90African trypanosomiasis_Homo sapiens_hsa05143-0.1807967
91Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1789042
92Hepatitis C_Homo sapiens_hsa05160-0.1749121
93Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1720975
94Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1638694
95Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1596304
96Type II diabetes mellitus_Homo sapiens_hsa04930-0.1541891
97Renin-angiotensin system_Homo sapiens_hsa04614-0.1462136
98Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1418443
99Regulation of autophagy_Homo sapiens_hsa04140-0.1330449
100Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1255199
101Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1075524
102Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.1075417
103Insulin signaling pathway_Homo sapiens_hsa04910-0.1063586
104Vascular smooth muscle contraction_Homo sapiens_hsa04270-0.1055862
105Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923-0.0988530
106Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0727981
107Circadian rhythm_Homo sapiens_hsa04710-0.0673351
108Amoebiasis_Homo sapiens_hsa05146-0.0465453
109Serotonergic synapse_Homo sapiens_hsa04726-0.0267661
110Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0224145

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »