ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	omega-hydroxylase P450 pathway (GO:0097267)	8.36618179
2	epoxygenase P450 pathway (GO:0019373)	8.31057952
3	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	7.58625542
4	L-phenylalanine catabolic process (GO:0006559)	7.58625542
5	L-phenylalanine metabolic process (GO:0006558)	7.25378821
6	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	7.25378821
7	aromatic amino acid family catabolic process (GO:0009074)	6.91395373
8	indole-containing compound catabolic process (GO:0042436)	6.33788121
9	indolalkylamine catabolic process (GO:0046218)	6.33788121
10	tryptophan catabolic process (GO:0006569)	6.33788121
11	kynurenine metabolic process (GO:0070189)	6.14354478
12	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	6.02242813
13	drug metabolic process (GO:0017144)	6.01565921
14	bile acid biosynthetic process (GO:0006699)	5.98240019
15	tryptophan metabolic process (GO:0006568)	5.95732456
16	glyoxylate metabolic process (GO:0046487)	5.95087499
17	oxidative demethylation (GO:0070989)	5.89621652
18	alpha-linolenic acid metabolic process (GO:0036109)	5.56223398
19	cysteine metabolic process (GO:0006534)	5.54277567
20	urea cycle (GO:0000050)	5.53393480
21	urea metabolic process (GO:0019627)	5.53393480
22	ethanol metabolic process (GO:0006067)	5.35639642
23	sulfur amino acid catabolic process (GO:0000098)	5.33671743
24	negative regulation of fibrinolysis (GO:0051918)	5.31186754
25	complement activation, alternative pathway (GO:0006957)	5.24962365
26	high-density lipoprotein particle remodeling (GO:0034375)	5.22050019
27	serine family amino acid catabolic process (GO:0009071)	5.21239325
28	protein carboxylation (GO:0018214)	5.20246696
29	peptidyl-glutamic acid carboxylation (GO:0017187)	5.20246696
30	regulation of protein activation cascade (GO:2000257)	5.18437616
31	regulation of fibrinolysis (GO:0051917)	5.14051939
32	nitrogen cycle metabolic process (GO:0071941)	5.09818239
33	bile acid metabolic process (GO:0008206)	5.08750017
34	regulation of plasminogen activation (GO:0010755)	5.08504488
35	fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)	5.04144973
36	aromatic amino acid family metabolic process (GO:0009072)	5.02005043
37	lysine metabolic process (GO:0006553)	4.99811204
38	lysine catabolic process (GO:0006554)	4.99811204
39	homocysteine metabolic process (GO:0050667)	4.91695816
40	phenylpropanoid metabolic process (GO:0009698)	4.88177278
41	regulation of complement activation (GO:0030449)	4.86531259
42	tyrosine metabolic process (GO:0006570)	4.73087499
43	negative regulation of blood coagulation (GO:0030195)	4.72667535
44	negative regulation of hemostasis (GO:1900047)	4.72667535
45	alpha-amino acid catabolic process (GO:1901606)	4.72413178
46	amino-acid betaine metabolic process (GO:0006577)	4.70283458
47	S-adenosylmethionine metabolic process (GO:0046500)	4.69764116
48	regulation of triglyceride catabolic process (GO:0010896)	4.61559018
49	reverse cholesterol transport (GO:0043691)	4.55374003
50	cellular ketone body metabolic process (GO:0046950)	4.54748675
51	regulation of cholesterol esterification (GO:0010872)	4.53662636
52	indolalkylamine metabolic process (GO:0006586)	4.48560171
53	plasma lipoprotein particle remodeling (GO:0034369)	4.48510743
54	protein-lipid complex remodeling (GO:0034368)	4.48510743
55	macromolecular complex remodeling (GO:0034367)	4.48510743
56	triglyceride homeostasis (GO:0070328)	4.47657267
57	acylglycerol homeostasis (GO:0055090)	4.47657267
58	negative regulation of cholesterol transport (GO:0032375)	4.45882443
59	negative regulation of sterol transport (GO:0032372)	4.45882443
60	coenzyme catabolic process (GO:0009109)	4.44488528
61	glycine metabolic process (GO:0006544)	4.42205393
62	cellular glucuronidation (GO:0052695)	4.39479044
63	amine catabolic process (GO:0009310)	4.39254979
64	cellular biogenic amine catabolic process (GO:0042402)	4.39254979
65	cellular amino acid catabolic process (GO:0009063)	4.36776392
66	acute-phase response (GO:0006953)	4.36065748
67	bile acid and bile salt transport (GO:0015721)	4.35484023
68	glutamate metabolic process (GO:0006536)	4.35325133
69	serine family amino acid metabolic process (GO:0009069)	4.31191728
70	negative regulation of coagulation (GO:0050819)	4.29857586
71	imidazole-containing compound metabolic process (GO:0052803)	4.28889111
72	phospholipid efflux (GO:0033700)	4.27193038
73	ethanol oxidation (GO:0006069)	4.24390569
74	fat-soluble vitamin biosynthetic process (GO:0042362)	4.23737967
75	regulation of humoral immune response (GO:0002920)	4.21657137
76	negative regulation of protein activation cascade (GO:2000258)	4.20265350
77	cellular modified amino acid catabolic process (GO:0042219)	4.19625363
78	negative regulation of wound healing (GO:0061045)	4.19561790
79	benzene-containing compound metabolic process (GO:0042537)	4.19216258
80	drug catabolic process (GO:0042737)	4.15426058
81	plasma lipoprotein particle clearance (GO:0034381)	4.15341606
82	alkaloid metabolic process (GO:0009820)	4.12868552
83	response to mercury ion (GO:0046689)	4.11025497
84	serine family amino acid biosynthetic process (GO:0009070)	4.08060356
85	dicarboxylic acid biosynthetic process (GO:0043650)	4.05545531
86	positive regulation of blood coagulation (GO:0030194)	4.01427691
87	positive regulation of hemostasis (GO:1900048)	4.01427691
88	aldehyde catabolic process (GO:0046185)	3.99679642
89	intestinal cholesterol absorption (GO:0030299)	3.97585595
90	cholesterol efflux (GO:0033344)	3.96897833
91	glucuronate metabolic process (GO:0019585)	3.93736925
92	uronic acid metabolic process (GO:0006063)	3.93736925
93	ketone body metabolic process (GO:1902224)	3.93596349
94	arginine metabolic process (GO:0006525)	3.92896507
95	opsonization (GO:0008228)	3.92628070
96	short-chain fatty acid metabolic process (GO:0046459)	3.92019409
97	disruption of cells of other organism involved in symbiotic interaction (GO:0051818)	3.89430480
98	killing of cells in other organism involved in symbiotic interaction (GO:0051883)	3.89430480
99	acetyl-CoA metabolic process (GO:0006084)	3.88364678
100	urate metabolic process (GO:0046415)	3.84285399
101	low-density lipoprotein particle remodeling (GO:0034374)	3.83773867
102	regulation of bile acid biosynthetic process (GO:0070857)	3.83171896
103	carboxylic acid catabolic process (GO:0046395)	3.82945075
104	organic acid catabolic process (GO:0016054)	3.82945075
105	fibrinolysis (GO:0042730)	3.82760999
106	drug transmembrane transport (GO:0006855)	3.81276715
107	plasma lipoprotein particle assembly (GO:0034377)	3.75804753
108	flavonoid metabolic process (GO:0009812)	3.75172883
109	negative regulation of lipase activity (GO:0060192)	3.74171379
110	positive regulation of heterotypic cell-cell adhesion (GO:0034116)	3.74152992
111	regulation of cholesterol homeostasis (GO:2000188)	3.73516149
112	cofactor catabolic process (GO:0051187)	3.73021229
113	hormone catabolic process (GO:0042447)	3.71508948
114	positive regulation of coagulation (GO:0050820)	3.71335588
115	complement activation, classical pathway (GO:0006958)	3.67989809
116	polyketide metabolic process (GO:0030638)	3.67447161
117	doxorubicin metabolic process (GO:0044598)	3.67447161
118	daunorubicin metabolic process (GO:0044597)	3.67447161
119	aspartate family amino acid catabolic process (GO:0009068)	3.66987449
120	phospholipid homeostasis (GO:0055091)	3.66881186
121	exogenous drug catabolic process (GO:0042738)	3.66742246
122	cytolysis (GO:0019835)	3.65464369
123	cholesterol homeostasis (GO:0042632)	3.65046245
124	complement activation (GO:0006956)	3.64316339
125	blood coagulation, intrinsic pathway (GO:0007597)	3.63287926
126	positive regulation of lipid catabolic process (GO:0050996)	3.60976817
127	sterol homeostasis (GO:0055092)	3.60020991
128	2-oxoglutarate metabolic process (GO:0006103)	3.58781450
129	protein activation cascade (GO:0072376)	3.58631408
130	positive regulation of lipoprotein lipase activity (GO:0051006)	3.58330650
131	positive regulation of triglyceride lipase activity (GO:0061365)	3.58330650
132	very-low-density lipoprotein particle assembly (GO:0034379)	3.58213875
133	heme transport (GO:0015886)	3.55050596
134	primary alcohol catabolic process (GO:0034310)	3.53561806
135	xenobiotic metabolic process (GO:0006805)	3.48731024
136	sodium-independent organic anion transport (GO:0043252)	3.46306068
137	negative regulation of complement activation (GO:0045916)	3.39636891

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	* RXR_22158963_ChIP-Seq_LIVER_Mouse	8.34610592
2	* PPARA_22158963_ChIP-Seq_LIVER_Mouse	7.14562030
3	EGR1_23403033_ChIP-Seq_LIVER_Mouse	6.92925396
4	* LXR_22158963_ChIP-Seq_LIVER_Mouse	6.46301434
5	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	5.23229717
6	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	4.91323096
7	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	4.91220312
8	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	4.03504841
9	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	3.90448026
10	TCF7L2_21901280_ChIP-Seq_H4IIE_Rat	2.08409418
11	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.06070918
12	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	2.01144867
13	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	11.8137172
14	FOXA2_19822575_ChIP-Seq_HepG2_Human	1.62374443
15	CLOCK_20551151_ChIP-Seq_293T_Human	1.58018523
16	HTT_18923047_ChIP-ChIP_STHdh_Human	1.52349822
17	* HNF4A_19822575_ChIP-Seq_HepG2_Human	1.42400288
18	GATA1_22025678_ChIP-Seq_K562_Human	1.36453315
19	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.22209521
20	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	1.21389140
21	RXRA_24833708_ChIP-Seq_LIVER_Mouse	1.17701365
22	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.15380993
23	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.09380093
24	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.05634014
25	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.04962784
26	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.04697859
27	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.04695421
28	SOX2_27498859_Chip-Seq_STOMACH_Mouse	0.96213673
29	ESR1_15608294_ChIP-ChIP_MCF-7_Human	0.95247795
30	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	0.94084944
31	RARG_19884340_ChIP-ChIP_MEFs_Mouse	0.90418791
32	BP1_19119308_ChIP-ChIP_Hs578T_Human	0.89820115
33	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	0.89249052
34	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	0.88173663
35	CDX2_19796622_ChIP-Seq_MESCs_Mouse	0.86676786
36	GATA4_25053715_ChIP-Seq_YYC3_Human	0.84727971
37	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.83815933
38	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	0.81862204
39	HNFA_21074721_ChIP-Seq_CACO-2_Human	0.80685654
40	IRF8_22096565_ChIP-ChIP_GC-B_Human	0.79861442
41	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	0.78405774
42	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	0.78261349
43	KAP1_22055183_ChIP-Seq_ESCs_Mouse	0.78135688
44	Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse	0.74985547
45	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	0.74541815
46	ESR2_21235772_ChIP-Seq_MCF-7_Human	0.73767839
47	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.73096449
48	PHF8_20622853_ChIP-Seq_HELA_Human	0.73092012
49	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	0.71741318
50	CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse	0.71739241
51	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	0.71302474
52	RARA_24833708_ChIP-Seq_LIVER_Mouse	0.70976249
53	SOX2_21211035_ChIP-Seq_LN229_Human	0.70677547
54	TP53_18474530_ChIP-ChIP_U2OS_Human	0.70354248
55	ZNF263_19887448_ChIP-Seq_K562_Human	0.68804926
56	SALL4_18804426_ChIP-ChIP_XEN_Mouse	0.68599849
57	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	0.68473273
58	NRF2_20460467_ChIP-Seq_MEFs_Mouse	0.68473273
59	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.66195323
60	RAC3_21632823_ChIP-Seq_H3396_Human	0.65038159
61	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	0.64407441
62	SPI1_20517297_ChIP-Seq_HL60_Human	0.64084234
63	NFYA_21822215_ChIP-Seq_K562_Human	0.63864403
64	NR0B1_18358816_ChIP-ChIP_MESCs_Mouse	0.63583153
65	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.63408748
66	RAD21_21589869_ChIP-Seq_MESCs_Mouse	0.63262804
67	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.62072637
68	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.61951685
69	DNAJC2_21179169_ChIP-ChIP_NT2_Human	0.61354230
70	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	0.61204522
71	RARB_24833708_ChIP-Seq_LIVER_Mouse	0.60674148
72	PPARG_20176806_ChIP-Seq_3T3-L1_Mouse	0.60633871
73	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	0.59430379
74	CEBPB_22108803_ChIP-Seq_LS180_Human	0.58683241
75	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.58573602
76	ER_23166858_ChIP-Seq_MCF-7_Human	0.58078972
77	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.58053712
78	SMC4_20622854_ChIP-Seq_HELA_Human	0.57855389
79	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.57540080
80	ESR1_21235772_ChIP-Seq_MCF-7_Human	0.56939607
81	IGF1R_20145208_ChIP-Seq_DFB_Human	0.56842532
82	EGR1_19032775_ChIP-ChIP_M12_Human	0.56079008
83	LXR_22292898_ChIP-Seq_THP-1_Human	0.55339315
84	CDX2_20551321_ChIP-Seq_CACO-2_Human	0.54528666
85	STAT3_1855785_ChIP-Seq_MESCs_Mouse	0.53939187
86	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.53546698
87	MYC_19915707_ChIP-ChIP_AK7_Human	0.53533669
88	FOXA1_25552417_ChIP-Seq_VCAP_Human	0.53404497
89	SOX2_20726797_ChIP-Seq_SW620_Human	0.53321705
90	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.53087093
91	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	0.53082477
92	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.52889516
93	CBX2_22325352_ChIP-Seq_293T-Rex_Human	0.52821956
94	AR_20517297_ChIP-Seq_VCAP_Human	0.52681110
95	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	0.52530295
96	GATA2_21666600_ChIP-Seq_HMVEC_Human	0.52037898
97	* GATA2_20887958_ChIP-Seq_HPC-7_Mouse	0.51595920
98	ESET_19884257_ChIP-Seq_ESCs_Mouse	0.51438749
99	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.51211430
100	STAT1_17558387_ChIP-Seq_HELA_Human	0.50932883
101	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	0.50713578
102	CBP_21632823_ChIP-Seq_H3396_Human	0.50671546
103	MYC_19829295_ChIP-Seq_ESCs_Human	0.49895516
104	FOXA1_26743006_Chip-Seq_LNCaP-abl_Human	0.48976192
105	TAF15_26573619_Chip-Seq_HEK293_Human	0.48082104
106	PPARG_20887899_ChIP-Seq_3T3-L1_Mouse	0.47461199
107	FOXO3_23340844_ChIP-Seq_DLD1_Human	0.47404801
108	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	0.46836672
109	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	0.46390156
110	P53_21459846_ChIP-Seq_SAOS-2_Human	0.45010899
111	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	0.44360317
112	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.43378151
113	ESR1_20079471_ChIP-ChIP_T-47D_Human	0.43332579
114	BCAT_22108803_ChIP-Seq_LS180_Human	0.43147847
115	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.43126200
116	TAF2_19829295_ChIP-Seq_ESCs_Human	0.42961337
117	PPAR_26484153_Chip-Seq_NCI-H1993_Human	0.42937784
118	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.42311173
119	GATA6_25053715_ChIP-Seq_YYC3_Human	0.42000709
120	FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human	0.41823638
121	ERG_21242973_ChIP-ChIP_JURKAT_Human	0.41686484
122	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.40883348
123	GATA1_19941826_ChIP-Seq_K562_Human	0.40725983
124	GATA1_19941827_ChIP-Seq_MEL_Mouse	0.40517671
125	GATA2_19941826_ChIP-Seq_K562_Human	0.40190838
126	STAT3_19079543_ChIP-ChIP_MESCs_Mouse	0.38783166
127	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	0.38687369
128	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.38268733
129	MYC_27129775_Chip-Seq_CORNEA_Mouse	0.36981136
130	CDX2_22108803_ChIP-Seq_LS180_Human	0.36497610
131	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.36263054
132	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	0.36235972
133	LUZP1_20508642_ChIP-Seq_ESCs_Mouse	0.35594242
134	CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.34999992
135	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.34782280

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002139_abnormal_hepatobiliary_system	8.31137312
2	MP0005360_urolithiasis	7.77455506
3	MP0005085_abnormal_gallbladder_physiolo	6.36552934
4	MP0005365_abnormal_bile_salt	6.06152305
5	MP0008875_abnormal_xenobiotic_pharmacok	5.14006760
6	MP0003806_abnormal_nucleotide_metabolis	4.20456541
7	MP0003252_abnormal_bile_duct	3.94316596
8	MP0010329_abnormal_lipoprotein_level	3.48897245
9	MP0009840_abnormal_foam_cell	3.07599080
10	MP0003195_calcinosis	2.98564164
11	MP0005083_abnormal_biliary_tract	2.98419409
12	MP0005332_abnormal_amino_acid	2.94630133
13	MP0001666_abnormal_nutrient_absorption	2.55903604
14	MP0004019_abnormal_vitamin_homeostasis	2.34800060
15	MP0003191_abnormal_cellular_cholesterol	2.17563283
16	MP0000609_abnormal_liver_physiology	2.11507538
17	MP0002118_abnormal_lipid_homeostasis	2.08431089
18	MP0002138_abnormal_hepatobiliary_system	2.06397144
19	MP0005319_abnormal_enzyme/_coenzyme	1.84995664
20	MP0003868_abnormal_feces_composition	1.83254120
21	MP0001764_abnormal_homeostasis	1.66034213
22	MP0005584_abnormal_enzyme/coenzyme_acti	1.60223424
23	MP0009697_abnormal_copulation	1.49096040
24	MP0005451_abnormal_body_composition	1.42247022
25	MP0009643_abnormal_urine_homeostasis	1.40662063
26	MP0003186_abnormal_redox_activity	1.31905858
27	MP0003011_delayed_dark_adaptation	1.24289330
28	MP0000598_abnormal_liver_morphology	1.14958261
29	MP0003656_abnormal_erythrocyte_physiolo	1.14069558
30	MP0005647_abnormal_sex_gland	1.13774972
31	MP0003705_abnormal_hypodermis_morpholog	1.09029945
32	MP0002132_abnormal_respiratory_system	1.06436514
33	MP0009764_decreased_sensitivity_to	1.05778833
34	MP0005636_abnormal_mineral_homeostasis	1.04829726
35	MP0000604_amyloidosis	1.01251844
36	MP0002254_reproductive_system_inflammat	0.99218787
37	MP0009763_increased_sensitivity_to	0.97505070
38	MP0010368_abnormal_lymphatic_system	0.88361441
39	MP0006036_abnormal_mitochondrial_physio	0.88356095
40	MP0008469_abnormal_protein_level	0.87260704
41	MP0005670_abnormal_white_adipose	0.87169684
42	MP0009642_abnormal_blood_homeostasis	0.87125500
43	MP0003879_abnormal_hair_cell	0.86902181
44	MP0005084_abnormal_gallbladder_morpholo	0.85266167
45	MP0002876_abnormal_thyroid_physiology	0.84958430
46	MP0005408_hypopigmentation	0.82239448
47	MP0002078_abnormal_glucose_homeostasis	0.78271554
48	MP0005376_homeostasis/metabolism_phenot	0.77050923
49	MP0009765_abnormal_xenobiotic_induced	0.75303415
50	MP0002971_abnormal_brown_adipose	0.74413629
51	MP0001915_intracranial_hemorrhage	0.74076822
52	MP0005535_abnormal_body_temperature	0.73561476
53	MP0005220_abnormal_exocrine_pancreas	0.73502069
54	MP0004130_abnormal_muscle_cell	0.73395479
55	MP0001756_abnormal_urination	0.72931809
56	MP0001661_extended_life_span	0.71981978
57	MP0005334_abnormal_fat_pad	0.69316001
58	MP0003690_abnormal_glial_cell	0.67675944
59	MP0003646_muscle_fatigue	0.65523925
60	MP0005266_abnormal_metabolism	0.63717043
61	MP0003329_amyloid_beta_deposits	0.63564903
62	MP0002332_abnormal_exercise_endurance	0.62354846
63	MP0006035_abnormal_mitochondrial_morpho	0.59955780
64	MP0002136_abnormal_kidney_physiology	0.59870853
65	MP0009053_abnormal_anal_canal	0.58059314
66	MP0005187_abnormal_penis_morphology	0.57410100
67	MP0005375_adipose_tissue_phenotype	0.55803789
68	MP0003959_abnormal_lean_body	0.54375750
69	MP0002928_abnormal_bile_duct	0.53664587
70	MP0005023_abnormal_wound_healing	0.53160302
71	MP0005448_abnormal_energy_balance	0.52888878
72	MP0000639_abnormal_adrenal_gland	0.52804838
73	MP0009785_altered_susceptibility_to	0.52563420
74	MP0004043_abnormal_pH_regulation	0.51501247
75	MP0003638_abnormal_response/metabolism_	0.49507215
76	MP0002282_abnormal_trachea_morphology	0.49456341
77	MP0005395_other_phenotype	0.48699627
78	MP0005164_abnormal_response_to	0.47440171
79	MP0002822_catalepsy	0.46536999
80	MP0002837_dystrophic_cardiac_calcinosis	0.46230603
81	MP0005666_abnormal_adipose_tissue	0.45793203
82	MP0008874_decreased_physiological_sensi	0.45346184
83	MP0002249_abnormal_larynx_morphology	0.44130945
84	MP0003724_increased_susceptibility_to	0.43896213
85	MP0005464_abnormal_platelet_physiology	0.43328250
86	MP0005167_abnormal_blood-brain_barrier	0.42916514
87	MP0003953_abnormal_hormone_level	0.42296453
88	MP0004782_abnormal_surfactant_physiolog	0.42004934
89	MP0003718_maternal_effect	0.41937735
90	MP0008873_increased_physiological_sensi	0.40681453
91	MP0003075_altered_response_to	0.39265406
92	MP0005166_decreased_susceptibility_to	0.38730161
93	MP0002269_muscular_atrophy	0.38133265
94	MP0000230_abnormal_systemic_arterial	0.38109566
95	MP0009672_abnormal_birth_weight	0.37846947
96	MP0003436_decreased_susceptibility_to	0.36530854
97	MP0008872_abnormal_physiological_respon	0.36465972
98	MP0002168_other_aberrant_phenotype	0.36464699
99	MP0001765_abnormal_ion_homeostasis	0.35780826
100	MP0005248_abnormal_Harderian_gland	0.35702572
101	MP0004381_abnormal_hair_follicle	0.35575566
102	MP0002796_impaired_skin_barrier	0.35081592
103	MP0009115_abnormal_fat_cell	0.34397899
104	MP0005330_cardiomyopathy	0.33961464
105	MP0000579_abnormal_nail_morphology	0.33404754
106	MP0000749_muscle_degeneration	0.33380290
107	MP0005058_abnormal_lysosome_morphology	0.32623647
108	MP0009384_cardiac_valve_regurgitation	0.32434863
109	MP0006082_CNS_inflammation	0.30754827
110	MP0004036_abnormal_muscle_relaxation	0.30592298
111	MP0002970_abnormal_white_adipose	0.30464811
112	MP0000249_abnormal_blood_vessel	0.28305675
113	MP0001853_heart_inflammation	0.28123970
114	MP0000751_myopathy	0.26491491
115	MP0006138_congestive_heart_failure	0.26229140
116	MP0001845_abnormal_inflammatory_respons	0.26141570
117	MP0004087_abnormal_muscle_fiber	0.25939856
118	MP0001881_abnormal_mammary_gland	0.25921779
119	MP0002135_abnormal_kidney_morphology	0.25588256
120	MP0001243_abnormal_dermal_layer	0.25358537
121	MP0003633_abnormal_nervous_system	0.24639007
122	MP0000920_abnormal_myelination	0.24532375
123	MP0001851_eye_inflammation	0.23083785
124	MP0004883_abnormal_blood_vessel	0.22903602
125	MP0002128_abnormal_blood_circulation	0.22867461
126	MP0000747_muscle_weakness	0.22500454
127	MP0005397_hematopoietic_system_phenotyp	0.21967911
128	MP0001545_abnormal_hematopoietic_system	0.21967911
129	MP0005452_abnormal_adipose_tissue	0.21358403

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of aromatic amino acid family metabolism (HP:0004338)	7.28609606
2	Intrahepatic cholestasis (HP:0001406)	7.22232662
3	Deep venous thrombosis (HP:0002625)	7.10183409
4	Abnormality of monocarboxylic acid metabolism (HP:0010996)	6.46714879
5	Prolonged partial thromboplastin time (HP:0003645)	6.27142956
6	Xanthomatosis (HP:0000991)	6.14504099
7	Hypobetalipoproteinemia (HP:0003563)	6.11155749
8	Hyperlipoproteinemia (HP:0010980)	5.32197360
9	Complement deficiency (HP:0004431)	5.28353263
10	Hyperammonemia (HP:0001987)	4.65120023
11	Hyperglycinemia (HP:0002154)	4.61032156
12	Joint hemorrhage (HP:0005261)	4.60752029
13	Hypolipoproteinemia (HP:0010981)	4.55150272
14	Ketosis (HP:0001946)	4.42134992
15	Abnormality of glutamine family amino acid metabolism (HP:0010902)	4.41702873
16	Epidermoid cyst (HP:0200040)	4.40365153
17	Hyperglycinuria (HP:0003108)	4.30381880
18	Abnormality of sulfur amino acid metabolism (HP:0004339)	4.24352991
19	Abnormality of glycine metabolism (HP:0010895)	4.21878514
20	Abnormality of serine family amino acid metabolism (HP:0010894)	4.21878514
21	Abnormality of the common coagulation pathway (HP:0010990)	4.20214041
22	Abnormality of aspartate family amino acid metabolism (HP:0010899)	4.17887877
23	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	4.16586050
24	Fat malabsorption (HP:0002630)	4.08749882
25	Abnormality of methionine metabolism (HP:0010901)	4.08457051
26	Hypoalphalipoproteinemia (HP:0003233)	3.96465668
27	Nephritis (HP:0000123)	3.88790147
28	Hypoglycemic coma (HP:0001325)	3.83227067
29	Abnormality of complement system (HP:0005339)	3.82786058
30	Conjugated hyperbilirubinemia (HP:0002908)	3.72896053
31	Abnormality of pyrimidine metabolism (HP:0004353)	3.72412070
32	Abnormality of the intrinsic pathway (HP:0010989)	3.58843482
33	Hypercholesterolemia (HP:0003124)	3.50665324
34	Abnormality of fatty-acid metabolism (HP:0004359)	3.49203468
35	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	3.35110218
36	Delayed CNS myelination (HP:0002188)	3.30187784
37	Ketoacidosis (HP:0001993)	3.28995592
38	Hyperbilirubinemia (HP:0002904)	3.28551991
39	Abnormality of nucleobase metabolism (HP:0010932)	3.22662525
40	Abnormality of serum amino acid levels (HP:0003112)	3.14613912
41	Steatorrhea (HP:0002570)	3.08346137
42	Abnormality of purine metabolism (HP:0004352)	2.97787752
43	Hepatocellular carcinoma (HP:0001402)	2.95097275
44	Gout (HP:0001997)	2.94179421
45	Myocardial infarction (HP:0001658)	2.91342621
46	Metabolic acidosis (HP:0001942)	2.86442813
47	Hypochromic microcytic anemia (HP:0004840)	2.78860253
48	Spontaneous abortion (HP:0005268)	2.76731646
49	Vascular calcification (HP:0004934)	2.76066308
50	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.72577432
51	Dicarboxylic aciduria (HP:0003215)	2.72577432
52	Skin nodule (HP:0200036)	2.72244860
53	Systemic lupus erythematosus (HP:0002725)	2.70715210
54	Lethargy (HP:0001254)	2.69237914
55	Purpura (HP:0000979)	2.50419791
56	Spastic diplegia (HP:0001264)	2.48097438
57	Osteomalacia (HP:0002749)	2.47530157
58	Cardiovascular calcification (HP:0011915)	2.44819083
59	Cerebral edema (HP:0002181)	2.44769737
60	Hypoglycemic seizures (HP:0002173)	2.41717477
61	Neonatal onset (HP:0003623)	2.41290569
62	Mitral stenosis (HP:0001718)	2.41125226
63	Irritability (HP:0000737)	2.40465420
64	Acanthocytosis (HP:0001927)	2.39602324
65	Abnormal gallbladder morphology (HP:0012437)	2.38276721
66	Malnutrition (HP:0004395)	2.37411219
67	Generalized aminoaciduria (HP:0002909)	2.33538396
68	Neonatal hypoglycemia (HP:0001998)	2.33453585
69	Reduced antithrombin III activity (HP:0001976)	2.33351524
70	Cholelithiasis (HP:0001081)	2.32416298
71	Glomerulonephritis (HP:0000099)	2.32005239
72	Recurrent gram-negative bacterial infections (HP:0005420)	2.29983273
73	Fair hair (HP:0002286)	2.29390041
74	Pulmonary embolism (HP:0002204)	2.27379632
75	Abnormal gallbladder physiology (HP:0012438)	2.22447783
76	Cholecystitis (HP:0001082)	2.22447783
77	Sensorimotor neuropathy (HP:0007141)	2.22217503
78	Enlarged kidneys (HP:0000105)	2.20263099
79	Late onset (HP:0003584)	2.19553022
80	Vomiting (HP:0002013)	2.19167611
81	Pancreatitis (HP:0001733)	2.14927027
82	Alkalosis (HP:0001948)	2.13852081
83	Esophageal varix (HP:0002040)	2.13461950
84	Rickets (HP:0002748)	2.10404051
85	Abnormality of vitamin metabolism (HP:0100508)	2.10363192
86	Hydroxyprolinuria (HP:0003080)	2.10264804
87	Abnormality of proline metabolism (HP:0010907)	2.10264804
88	Proximal tubulopathy (HP:0000114)	2.09634320
89	Brushfield spots (HP:0001088)	2.09169144
90	Amyloidosis (HP:0011034)	2.06525514
91	Opisthotonus (HP:0002179)	2.03505942
92	Menorrhagia (HP:0000132)	2.03488142
93	Increased purine levels (HP:0004368)	2.02237634
94	Hyperuricemia (HP:0002149)	2.02237634
95	Hyperphosphaturia (HP:0003109)	2.01501882
96	Gingival bleeding (HP:0000225)	1.99065286
97	Hemorrhage of the eye (HP:0011885)	1.98097446
98	Thrombophlebitis (HP:0004418)	1.98032622
99	Abnormality of the gallbladder (HP:0005264)	1.96600528
100	Hyperinsulinemic hypoglycemia (HP:0000825)	1.96142102
101	Abnormal enzyme/coenzyme activity (HP:0012379)	1.95202328
102	Hypophosphatemic rickets (HP:0004912)	1.94461613
103	Abnormality of urine glucose concentration (HP:0011016)	1.89752368
104	Glycosuria (HP:0003076)	1.89752368
105	Abnormal cartilage morphology (HP:0002763)	1.88595046
106	Increased mean platelet volume (HP:0011877)	1.86932845
107	Poikilocytosis (HP:0004447)	1.86755088
108	Renal cortical cysts (HP:0000803)	1.86574310
109	Bifid scrotum (HP:0000048)	1.84485683
110	Abnormality of the Achilles tendon (HP:0005109)	1.83344313
111	Joint swelling (HP:0001386)	1.82313030
112	Status epilepticus (HP:0002133)	1.81995916
113	Arthropathy (HP:0003040)	1.81148815
114	Elevated hepatic transaminases (HP:0002910)	1.80092418
115	Atrioventricular block (HP:0001678)	1.75964164
116	Elevated alkaline phosphatase (HP:0003155)	1.74641308
117	Increased serum ferritin (HP:0003281)	1.73526485
118	Abnormality of iron homeostasis (HP:0011031)	1.70961952
119	Cerebral palsy (HP:0100021)	1.70400882
120	Abnormal platelet volume (HP:0011876)	1.67484434
121	Abnormal platelet function (HP:0011869)	1.65168367
122	Impaired platelet aggregation (HP:0003540)	1.65168367
123	Hypertriglyceridemia (HP:0002155)	1.64215611
124	Epistaxis (HP:0000421)	1.62943785
125	Back pain (HP:0003418)	1.61607469
126	Gangrene (HP:0100758)	1.60799274
127	Abnormal urine phosphate concentration (HP:0012599)	1.59093443
128	Retinal atrophy (HP:0001105)	1.56781921
129	Abnormality of alkaline phosphatase activity (HP:0004379)	1.55227630
130	Abnormality of transition element cation homeostasis (HP:0011030)	1.55210880

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	BCKDK	7.24146036
2	SIK1	4.56372628
3	FGFR4	4.53570957
4	ERN1	4.14177199
5	OBSCN	3.22847338
6	INSRR	3.01798807
7	TAOK3	2.97588758
8	ERBB4	2.88437242
9	MAP2K4	2.25603226
10	MST1R	2.20616394
11	PKN2	2.06029070
12	PIK3CA	1.88254832
13	MAPK11	1.87386912
14	FLT3	1.74601317
15	TRIB3	1.73712837
16	PIK3CG	1.72045191
17	PRPF4B	1.61039517
18	LATS1	1.59870252
19	TYK2	1.58573497
20	ABL2	1.46411661
21	NTRK3	1.46139968
22	PTK6	1.44048886
23	DAPK2	1.42384013
24	MYLK	1.39393442
25	PHKG2	1.37397654
26	PHKG1	1.37397654
27	FGFR2	1.36210027
28	FRK	1.35247458
29	NEK9	1.34062735
30	MAP3K7	1.31318890
31	PINK1	1.25563875
32	KDR	1.25042559
33	NLK	1.24099877
34	STK38L	1.21714813
35	JAK2	1.19371859
36	PRKAA2	1.19307361
37	PDK2	1.18667994
38	MAP3K1	1.13968549
39	CAMKK2	1.10635299
40	GRK6	1.09520123
41	MAP3K14	1.05324416
42	PRKG1	1.01632589
43	MAP2K3	1.01016003
44	JAK1	0.98485177
45	ERBB2	0.97413551
46	TNK2	0.96310614
47	TBK1	0.95133106
48	MAPK4	0.94063989
49	PRKCZ	0.93826769
50	MAPKAPK3	0.92180170
51	MAP3K10	0.89897214
52	TIE1	0.87555891
53	WNK3	0.87267150
54	MOS	0.86805782
55	MAPK15	0.85447159
56	EPHB1	0.84257273
57	MET	0.83112171
58	MAP3K3	0.81156602
59	MAPK12	0.80789394
60	SGK3	0.77451515
61	CAMK1D	0.77451467
62	TTN	0.76394533
63	KSR2	0.76100864
64	CDK6	0.75607801
65	WNK4	0.75532330
66	PRKACG	0.75302271
67	PRKAA1	0.74363433
68	IRAK3	0.73814868
69	PRKACA	0.73565196
70	DYRK1B	0.73166697
71	GSK3A	0.72436338
72	ARAF	0.69422274
73	MAP3K11	0.67385387
74	TRPM7	0.67331524
75	MAP3K2	0.66585310
76	CSK	0.65925132
77	RIPK1	0.65609263
78	CAMK2G	0.65192927
79	MAP2K6	0.64949617
80	FER	0.64067017
81	PDGFRA	0.62589739
82	SGK2	0.62376086
83	EPHA3	0.60923226
84	TGFBR2	0.59258166
85	BLK	0.59140632
86	ZAP70	0.58624883
87	PDK4	0.58437870
88	PDK3	0.58437870
89	EPHA4	0.58304621
90	SGK223	0.57875623
91	SGK494	0.57875623
92	PTK2	0.56402222
93	LATS2	0.55680139
94	OXSR1	0.55132174
95	PDPK1	0.54659172
96	FGFR3	0.54591027
97	MAPK7	0.53347081
98	RPS6KA3	0.53270598
99	PRKCQ	0.50326837
100	SGK1	0.48924692
101	MARK3	0.48889906
102	PRKACB	0.48882420
103	CSF1R	0.47882108
104	DDR2	0.47837348
105	MAP3K13	0.46443615
106	IKBKE	0.45865626
107	MUSK	0.45410385
108	CSNK1G1	0.44601599
109	IGF1R	0.43690725
110	GRK1	0.42521657
111	AKT2	0.41055549
112	RPS6KB1	0.40752302
113	CSNK1D	0.39860815
114	PKN1	0.39020441
115	MAP3K5	0.38965314
116	CDC42BPA	0.38622344
117	TAOK2	0.38558220
118	PRKCG	0.38244704
119	RET	0.36387061
120	MAP2K1	0.36057629
121	CDK4	0.35709944
122	CAMK1G	0.35641476
123	IRAK2	0.35561255
124	CAMK4	0.33611155
125	PDK1	0.33544092
126	MTOR	0.33093839
127	MAP3K6	0.32949234
128	IRAK1	0.31745500
129	ICK	0.30567832
130	EGFR	0.30201618
131	PAK3	0.26977256
132	PRKCA	0.26964781
133	PBK	0.26444248
134	CSNK1G2	0.22537632
135	STK38	0.22158207
136	ABL1	0.20831555

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Primary bile acid biosynthesis_Homo sapiens_hsa00120	4.44724855
2	Nitrogen metabolism_Homo sapiens_hsa00910	3.48212712
3	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	3.41927813
4	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	3.29211170
5	Arginine biosynthesis_Homo sapiens_hsa00220	2.97918924
6	Tryptophan metabolism_Homo sapiens_hsa00380	2.73112784
7	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	2.70678692
8	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	2.66804507
9	Complement and coagulation cascades_Homo sapiens_hsa04610	2.62250796
10	Fatty acid degradation_Homo sapiens_hsa00071	2.53858207
11	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	2.52389971
12	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.49036750
13	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	2.34631677
14	Peroxisome_Homo sapiens_hsa04146	2.14102996
15	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	2.11955158
16	* Butanoate metabolism_Homo sapiens_hsa00650	2.07953356
17	Propanoate metabolism_Homo sapiens_hsa00640	2.05479503
18	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.92880283
19	Chemical carcinogenesis_Homo sapiens_hsa05204	1.91214220
20	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.89230706
21	Histidine metabolism_Homo sapiens_hsa00340	1.88986224
22	PPAR signaling pathway_Homo sapiens_hsa03320	1.86748836
23	Fatty acid metabolism_Homo sapiens_hsa01212	1.84157026
24	beta-Alanine metabolism_Homo sapiens_hsa00410	1.76194644
25	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.75318940
26	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.71693867
27	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.70450292
28	Retinol metabolism_Homo sapiens_hsa00830	1.70144366
29	Caffeine metabolism_Homo sapiens_hsa00232	1.69246215
30	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.67366298
31	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.65595374
32	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.62155943
33	Selenocompound metabolism_Homo sapiens_hsa00450	1.56561416
34	Bile secretion_Homo sapiens_hsa04976	1.53807448
35	Phenylalanine metabolism_Homo sapiens_hsa00360	1.53538573
36	Pyruvate metabolism_Homo sapiens_hsa00620	1.44413997
37	Tyrosine metabolism_Homo sapiens_hsa00350	1.41229443
38	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.40355372
39	Sulfur metabolism_Homo sapiens_hsa00920	1.37722139
40	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.31439673
41	Fatty acid elongation_Homo sapiens_hsa00062	1.30189715
42	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.26547237
43	Folate biosynthesis_Homo sapiens_hsa00790	1.19433015
44	ABC transporters_Homo sapiens_hsa02010	1.19229354
45	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.18973385
46	Carbon metabolism_Homo sapiens_hsa01200	1.17218244
47	Steroid biosynthesis_Homo sapiens_hsa00100	1.16120561
48	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.14517874
49	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.10611863
50	Fat digestion and absorption_Homo sapiens_hsa04975	1.09211860
51	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.00256739
52	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.99843081
53	Arginine and proline metabolism_Homo sapiens_hsa00330	0.98771235
54	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.95494275
55	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.94691389
56	Sulfur relay system_Homo sapiens_hsa04122	0.91385081
57	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.90929964
58	Lysine degradation_Homo sapiens_hsa00310	0.85969953
59	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.85133678
60	One carbon pool by folate_Homo sapiens_hsa00670	0.73076275
61	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.72964480
62	Glycerolipid metabolism_Homo sapiens_hsa00561	0.70823171
63	Glutathione metabolism_Homo sapiens_hsa00480	0.69354111
64	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.62041228
65	Pentose phosphate pathway_Homo sapiens_hsa00030	0.55676538
66	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.53626520
67	* Metabolic pathways_Homo sapiens_hsa01100	0.46372251
68	Pertussis_Homo sapiens_hsa05133	0.38338574
69	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.35709723
70	Prion diseases_Homo sapiens_hsa05020	0.33744611
71	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.26046955
72	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.24400237
73	Galactose metabolism_Homo sapiens_hsa00052	0.24321126
74	Insulin resistance_Homo sapiens_hsa04931	0.23501001
75	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.22923216
76	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.19248251
77	Linoleic acid metabolism_Homo sapiens_hsa00591	0.18580099
78	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.13874781
79	Glucagon signaling pathway_Homo sapiens_hsa04922	0.09632527
80	Other glycan degradation_Homo sapiens_hsa00511	0.08621345
81	AMPK signaling pathway_Homo sapiens_hsa04152	0.02771948
82	FoxO signaling pathway_Homo sapiens_hsa04068	-0.2515095
83	Mineral absorption_Homo sapiens_hsa04978	-0.2331569
84	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	-0.2330136
85	Protein digestion and absorption_Homo sapiens_hsa04974	-0.2313246
86	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	-0.2306854
87	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	-0.2284878
88	Sphingolipid metabolism_Homo sapiens_hsa00600	-0.2212692
89	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	-0.2117395
90	African trypanosomiasis_Homo sapiens_hsa05143	-0.1807967
91	Systemic lupus erythematosus_Homo sapiens_hsa05322	-0.1789042
92	Hepatitis C_Homo sapiens_hsa05160	-0.1749121
93	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	-0.1720975
94	Thyroid hormone synthesis_Homo sapiens_hsa04918	-0.1638694
95	Central carbon metabolism in cancer_Homo sapiens_hsa05230	-0.1596304
96	Type II diabetes mellitus_Homo sapiens_hsa04930	-0.1541891
97	Renin-angiotensin system_Homo sapiens_hsa04614	-0.1462136
98	Arachidonic acid metabolism_Homo sapiens_hsa00590	-0.1418443
99	Regulation of autophagy_Homo sapiens_hsa04140	-0.1330449
100	Glycosaminoglycan degradation_Homo sapiens_hsa00531	-0.1255199
101	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	-0.1075524
102	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	-0.1075417
103	Insulin signaling pathway_Homo sapiens_hsa04910	-0.1063586
104	Vascular smooth muscle contraction_Homo sapiens_hsa04270	-0.1055862
105	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	-0.0988530
106	Ovarian steroidogenesis_Homo sapiens_hsa04913	-0.0727981
107	Circadian rhythm_Homo sapiens_hsa04710	-0.0673351
108	Amoebiasis_Homo sapiens_hsa05146	-0.0465453
109	Serotonergic synapse_Homo sapiens_hsa04726	-0.0267661
110	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	-0.0224145

ACSM5

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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