ACSS1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a mitochondrial acetyl-CoA synthetase enzyme. A similar protein in mice plays an important role in the tricarboxylic acid cycle by catalyzing the conversion of acetate to acetyl CoA. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1tricarboxylic acid cycle (GO:0006099)7.50387917
2sarcomere organization (GO:0045214)6.90200708
3cardiac myofibril assembly (GO:0055003)6.33991151
4negative regulation of potassium ion transmembrane transporter activity (GO:1901017)6.04346816
5regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)6.02319293
6negative regulation of potassium ion transmembrane transport (GO:1901380)5.66653681
7cardiac muscle contraction (GO:0060048)5.60349281
8myofibril assembly (GO:0030239)5.50023500
9positive regulation of gamma-delta T cell activation (GO:0046645)5.46493031
10regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO5.42434351
11carnitine shuttle (GO:0006853)5.41631425
12regulation of acyl-CoA biosynthetic process (GO:0050812)5.38009200
13negative regulation of erythrocyte differentiation (GO:0045647)5.36468384
14regulation of actin filament-based movement (GO:1903115)5.33805983
15regulation of relaxation of muscle (GO:1901077)5.33473593
16lysine catabolic process (GO:0006554)5.27403243
17lysine metabolic process (GO:0006553)5.27403243
18positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)5.27271818
19NADH metabolic process (GO:0006734)5.25562237
20regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)5.17363688
21regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)5.16498605
22antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.15580081
23antigen processing and presentation of endogenous antigen (GO:0019883)5.07850884
242-oxoglutarate metabolic process (GO:0006103)5.07133135
25regulation of gamma-delta T cell differentiation (GO:0045586)4.99063916
26tricarboxylic acid metabolic process (GO:0072350)4.97818437
27regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)4.81757439
28antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.81114146
29regulation of coenzyme metabolic process (GO:0051196)4.79339883
30regulation of cofactor metabolic process (GO:0051193)4.79339883
31positive thymic T cell selection (GO:0045059)4.78929257
32negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.75011587
33negative regulation of cell killing (GO:0031342)4.75011587
34ventricular cardiac muscle cell action potential (GO:0086005)4.73792356
35regulation of gamma-delta T cell activation (GO:0046643)4.70343711
36bundle of His cell to Purkinje myocyte communication (GO:0086069)4.63749320
37carnitine transport (GO:0015879)4.63536986
38amino-acid betaine transport (GO:0015838)4.63536986
39fatty acid transmembrane transport (GO:1902001)4.62728301
40oxidative phosphorylation (GO:0006119)4.60811634
41cardiac muscle cell development (GO:0055013)4.58900405
42aspartate family amino acid catabolic process (GO:0009068)4.53434077
43fatty acid beta-oxidation (GO:0006635)4.51764878
44carnitine transmembrane transport (GO:1902603)4.51087607
45antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.44835013
46actin-myosin filament sliding (GO:0033275)4.39624415
47muscle filament sliding (GO:0030049)4.39624415
48cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.37731865
49cardiac cell development (GO:0055006)4.33634347
50regulation of skeletal muscle contraction (GO:0014819)4.31106805
51creatine metabolic process (GO:0006600)4.29306376
52adult heart development (GO:0007512)4.23465456
53actomyosin structure organization (GO:0031032)4.20731786
54cardiac muscle hypertrophy (GO:0003300)4.18464769
55positive regulation of B cell differentiation (GO:0045579)4.17882385
56regulation of cardiac muscle cell contraction (GO:0086004)4.16546779
57regulation of B cell receptor signaling pathway (GO:0050855)4.16327865
58valine metabolic process (GO:0006573)4.14806621
59cell communication by electrical coupling (GO:0010644)4.13000411
60striated muscle contraction (GO:0006941)4.12917628
61mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.08465921
62quaternary ammonium group transport (GO:0015697)4.07137861
63B cell receptor signaling pathway (GO:0050853)4.05769281
64regulation of sequestering of triglyceride (GO:0010889)4.05127593
65relaxation of cardiac muscle (GO:0055119)4.02250662
66regulation of sarcomere organization (GO:0060297)4.01230093
67regulation of the force of heart contraction (GO:0002026)3.99848634
68cell communication involved in cardiac conduction (GO:0086065)3.96907649
69striated muscle hypertrophy (GO:0014897)3.95265437
70regulation of fatty acid oxidation (GO:0046320)3.94924277
71succinate metabolic process (GO:0006105)3.94689494
72negative thymic T cell selection (GO:0045060)3.94410995
73respiratory electron transport chain (GO:0022904)3.92313315
74regulation of membrane repolarization (GO:0060306)3.90913805
75positive T cell selection (GO:0043368)3.88801631
76heart trabecula formation (GO:0060347)3.88238951
77regulation of sulfur metabolic process (GO:0042762)3.87770875
78thymic T cell selection (GO:0045061)3.87435246
79regulation of cell communication by electrical coupling (GO:0010649)3.85792763
80branched-chain amino acid metabolic process (GO:0009081)3.84543865
81branched-chain amino acid catabolic process (GO:0009083)3.83673421
82electron transport chain (GO:0022900)3.81712656
83negative T cell selection (GO:0043383)3.80762892
84regulation of striated muscle contraction (GO:0006942)3.79594089
85aminoglycoside antibiotic metabolic process (GO:0030647)3.73500357
86cardiac muscle tissue morphogenesis (GO:0055008)3.73244500
87plasma membrane repair (GO:0001778)3.72849834
88regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.69685656
89ATP synthesis coupled proton transport (GO:0015986)3.65136364
90energy coupled proton transport, down electrochemical gradient (GO:0015985)3.65136364
91mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.63912231
92positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.62932111
93ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.62198277
94detection of bacterium (GO:0016045)3.61300337
95biotin metabolic process (GO:0006768)3.59322782
96T cell selection (GO:0045058)3.59242983
97cellular response to zinc ion (GO:0071294)3.58792123
98fatty acid catabolic process (GO:0009062)3.56383468
99lipid oxidation (GO:0034440)3.54774281
100carnitine metabolic process (GO:0009437)3.54765706
101fatty acid oxidation (GO:0019395)3.54479939
102actin-mediated cell contraction (GO:0070252)3.54266926
103regulation of B cell differentiation (GO:0045577)3.54087890
104detection of other organism (GO:0098543)3.47772247
105heart contraction (GO:0060047)3.47683306
106heart process (GO:0003015)3.47683306
107muscle hypertrophy (GO:0014896)3.46576545
108positive regulation of granulocyte differentiation (GO:0030854)3.46449883
109oxaloacetate metabolic process (GO:0006107)3.44404556
110immunoglobulin mediated immune response (GO:0016064)3.44340470
111sarcoplasmic reticulum calcium ion transport (GO:0070296)3.40453376
112pyrimidine ribonucleoside catabolic process (GO:0046133)3.38367781
113potassium ion import (GO:0010107)3.34858563
114gas transport (GO:0015669)3.29507042
115positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.28964325
116muscle tissue morphogenesis (GO:0060415)3.28506806
117Peyers patch development (GO:0048541)3.27289206
118mucosal-associated lymphoid tissue development (GO:0048537)3.27289206
119regulation of ATPase activity (GO:0043462)3.24694406
120regulation of ATP catabolic process (GO:1903289)3.24694406
121cardiac muscle cell action potential involved in contraction (GO:0086002)3.24072930
122negative regulation of lymphocyte mediated immunity (GO:0002707)3.23069827
123regulation of cardiac muscle contraction (GO:0055117)3.20829109
124cardiac muscle cell action potential (GO:0086001)3.20347471
125germinal center formation (GO:0002467)3.17827183
126ubiquinone biosynthetic process (GO:0006744)3.12858834
127quinone biosynthetic process (GO:1901663)3.12858834
128regulation of granulocyte differentiation (GO:0030852)3.10717961
129modulation by symbiont of host immune response (GO:0052553)3.09576763
130positive regulation by symbiont of host defense response (GO:0052509)3.09576763
131modulation by symbiont of host defense response (GO:0052031)3.09576763
132modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.09576763
133modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.09576763
134positive regulation by organism of defense response of other organism involved in symbiotic interact3.09576763
135negative regulation of leukocyte mediated immunity (GO:0002704)3.07529092
136negative regulation of heart growth (GO:0061117)3.02438611
137negative regulation of cardiac muscle tissue growth (GO:0055022)3.02438611
138leukocyte aggregation (GO:0070486)3.00943786
139regulation of mast cell degranulation (GO:0043304)2.95752042
140neutrophil activation involved in immune response (GO:0002283)2.93994057
141regulation of myeloid leukocyte mediated immunity (GO:0002886)2.88232237
142regulation of dendritic cell antigen processing and presentation (GO:0002604)2.82863086
143positive regulation of Rap GTPase activity (GO:0032854)2.79691943
144regulation of T-helper 2 cell differentiation (GO:0045628)2.78851732
145macrophage activation involved in immune response (GO:0002281)2.75306105
146regulation of leukocyte degranulation (GO:0043300)2.74897886
147negative regulation of granulocyte differentiation (GO:0030853)2.71212824
148interferon-gamma-mediated signaling pathway (GO:0060333)2.70126869
149megakaryocyte development (GO:0035855)2.68797465
150regulation of interleukin-4 production (GO:0032673)2.65866889
151response to interleukin-15 (GO:0070672)2.64886818
152definitive hemopoiesis (GO:0060216)2.63171857
153detection of external biotic stimulus (GO:0098581)2.62707892
154regulation of mast cell activation involved in immune response (GO:0033006)2.62645506
155positive regulation of antigen processing and presentation (GO:0002579)2.62044325
156T cell migration (GO:0072678)2.62036820
157cellular extravasation (GO:0045123)2.60142641
158regulation of tolerance induction (GO:0002643)2.59761251
159positive regulation of type 2 immune response (GO:0002830)2.59115593
160regulation of antigen processing and presentation (GO:0002577)2.58959009
161negative regulation of T cell mediated immunity (GO:0002710)2.58224695
162antigen receptor-mediated signaling pathway (GO:0050851)2.57672970
163response to peptidoglycan (GO:0032494)2.57635734
164response to muramyl dipeptide (GO:0032495)2.57209257
165response to type I interferon (GO:0034340)2.56303716
166regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.56267454
167tolerance induction (GO:0002507)2.54072083
168cellular response to type I interferon (GO:0071357)2.53871648
169type I interferon signaling pathway (GO:0060337)2.53871648
170mannose metabolic process (GO:0006013)2.53330645
171negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.53162153
172positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.52723019
173regulation of necroptotic process (GO:0060544)2.52446482
174regulation of germinal center formation (GO:0002634)2.51718404
175regulation of ARF protein signal transduction (GO:0032012)2.50991163
176hemoglobin metabolic process (GO:0020027)2.50833677
177actin filament polymerization (GO:0030041)2.50152037
178response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.49005098
179response to host immune response (GO:0052572)2.49005098
180positive regulation of interleukin-4 production (GO:0032753)2.46627263
181positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.46156916
182phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.45986006
183regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.45009372
184B cell mediated immunity (GO:0019724)2.42540807
185oxygen transport (GO:0015671)2.42306070
186defense response to protozoan (GO:0042832)2.38813118
187regulation of regulated secretory pathway (GO:1903305)2.36134639
188regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.35661339
189negative regulation of innate immune response (GO:0045824)2.34833680
190response to host (GO:0075136)2.33370159
191response to host defenses (GO:0052200)2.33370159
192response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.33370159
193positive regulation of tolerance induction (GO:0002645)2.32962557
194mature B cell differentiation involved in immune response (GO:0002313)2.32343050
195response to protozoan (GO:0001562)2.32332427
196regulation of necrotic cell death (GO:0010939)2.32140997
197negative regulation of myotube differentiation (GO:0010832)2.31660577
198lymphocyte homeostasis (GO:0002260)2.31429660
199cellular response to thyroid hormone stimulus (GO:0097067)2.30663804

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.28562533
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.07757608
3TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.68269327
4ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.36240643
5TBX20_22328084_ChIP-Seq_HEART_Mouse3.04139317
6TBX20_22080862_ChIP-Seq_HEART_Mouse3.04139317
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.93439793
8ZNF263_19887448_ChIP-Seq_K562_Human2.70234909
9GATA1_22025678_ChIP-Seq_K562_Human2.68805802
10IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.34353700
11RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.32033760
12MYC_22102868_ChIP-Seq_BL_Human2.31110779
13ESR1_20079471_ChIP-ChIP_T-47D_Human2.29399665
14EP300_21415370_ChIP-Seq_HL-1_Mouse2.28857944
15THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.27025454
16VDR_21846776_ChIP-Seq_THP-1_Human2.24414448
17ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.12967415
18VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.11449732
19RARG_19884340_ChIP-ChIP_MEFs_Mouse2.00643194
20* GATA1_19941827_ChIP-Seq_MEL_Mouse1.98157648
21IRF8_22096565_ChIP-ChIP_GC-B_Human1.95175289
22KDM2B_26808549_Chip-Seq_SUP-B15_Human1.95070311
23GATA1_19941826_ChIP-Seq_K562_Human1.90037242
24* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.88245991
25NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.87512910
26RUNX1_22412390_ChIP-Seq_EML_Mouse1.85493250
27SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.85319606
28SCL_19346495_ChIP-Seq_HPC-7_Human1.85080801
29ESR2_21235772_ChIP-Seq_MCF-7_Human1.83368317
30MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.82398838
31CLOCK_20551151_ChIP-Seq_293T_Human1.80432949
32* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.75421480
33GATA4_21415370_ChIP-Seq_HL-1_Mouse1.75029111
34E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.74457737
35CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.73654727
36* MAF_26560356_Chip-Seq_TH1_Human1.71769472
37NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.69599907
38KDM2B_26808549_Chip-Seq_DND41_Human1.68989207
39PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.68447645
40NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.64591470
41DROSHA_22980978_ChIP-Seq_HELA_Human1.63735696
42NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.61928225
43TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.61846579
44LXR_22292898_ChIP-Seq_THP-1_Human1.60981661
45KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.59709650
46PPARA_22158963_ChIP-Seq_LIVER_Mouse1.59531811
47TCF7_22412390_ChIP-Seq_EML_Mouse1.58322878
48SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.58141126
49RUNX_20019798_ChIP-Seq_JUKART_Human1.57872180
50GATA2_19941826_ChIP-Seq_K562_Human1.57314841
51* MYB_26560356_Chip-Seq_TH1_Human1.57259591
52SPI1_23127762_ChIP-Seq_K562_Human1.56996809
53IRF8_27001747_Chip-Seq_BMDM_Mouse1.55533853
54MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.51942677
55FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.51838207
56* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.49547225
57RACK7_27058665_Chip-Seq_MCF-7_Human1.48282638
58IRF8_21731497_ChIP-ChIP_J774_Mouse1.47535380
59UTX_26944678_Chip-Seq_JUKART_Human1.44027416
60ELK3_25401928_ChIP-Seq_HUVEC_Human1.43821304
61* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.43698667
62* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.43523468
63SMC4_20622854_ChIP-Seq_HELA_Human1.43328255
64CIITA_25753668_ChIP-Seq_RAJI_Human1.41648956
65STAT3_1855785_ChIP-Seq_MESCs_Mouse1.41073512
66SA1_27219007_Chip-Seq_ERYTHROID_Human1.39430981
67MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.38559594
68* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.37657322
69EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.37495499
70SPI1_23547873_ChIP-Seq_NB4_Human1.37342708
71MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.34843294
72CTCF_27219007_Chip-Seq_ERYTHROID_Human1.32647801
73STAT4_19710469_ChIP-ChIP_TH1__Mouse1.32385438
74KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.31623953
75VDR_24763502_ChIP-Seq_THP-1_Human1.27227219
76* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.27007150
77P68_20966046_ChIP-Seq_HELA_Human1.26618933
78* RUNX1_27514584_Chip-Seq_MCF-7_Human1.26448469
79PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.25217824
80KDM2B_26808549_Chip-Seq_JURKAT_Human1.22770923
81* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.21548488
82KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.21277519
83PU.1_20513432_ChIP-Seq_Bcells_Mouse1.20714638
84STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.20610152
85HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.20108131
86DNAJC2_21179169_ChIP-ChIP_NT2_Human1.18204815
87IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.17008618
88NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.16937276
89ESR1_21235772_ChIP-Seq_MCF-7_Human1.16762905
90* FOXO3_23340844_ChIP-Seq_DLD1_Human1.16003367
91* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.14551029
92MYB_26560356_Chip-Seq_TH2_Human1.14527960
93PPAR_26484153_Chip-Seq_NCI-H1993_Human1.13824351
94CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.12978732
95KDM2B_26808549_Chip-Seq_K562_Human1.12161130
96LXR_22158963_ChIP-Seq_LIVER_Mouse1.12030866
97BCL6_27268052_Chip-Seq_Bcells_Human1.11971340
98VDR_24787735_ChIP-Seq_THP-1_Human1.11080880
99BCOR_27268052_Chip-Seq_Bcells_Human1.10610362
100EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.10457473
101* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.10154209
102LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.09689031
103IKZF1_21737484_ChIP-ChIP_HCT116_Human1.08992407
104VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.08761387
105P300_27268052_Chip-Seq_Bcells_Human1.06308809
106PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06231830
107ATF3_27146783_Chip-Seq_COLON_Human1.06065724
108PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.05997123
109CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.05923067
110TET1_21451524_ChIP-Seq_MESCs_Mouse1.05387242
111BRD4_27068464_Chip-Seq_AML-cells_Mouse1.05155186
112GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.04021247
113* CREB1_26743006_Chip-Seq_LNCaP_Human1.03806612
114* GATA3_27048872_Chip-Seq_THYMUS_Human1.03349641
115SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.02687023
116RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.02387431
117SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02309651
118* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.02264081
119TP63_22573176_ChIP-Seq_HFKS_Human1.01813786
120GATA2_21666600_ChIP-Seq_HMVEC_Human0.99978385
121* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.99690005
122PHF8_20622854_ChIP-Seq_HELA_Human0.99516200
123CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99080331
124TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.98782067
125RXR_22158963_ChIP-Seq_LIVER_Mouse0.97443526
126KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.95339135
127CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.95047344
128NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.94734346
129* GATA6_25053715_ChIP-Seq_YYC3_Human0.93864700
130NCOR1_26117541_ChIP-Seq_K562_Human0.93653983
131GATA1_19941827_ChIP-Seq_MEL86_Mouse0.93470617
132MAF_26560356_Chip-Seq_TH2_Human0.92989779
133ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.92053644
134CTCF_21964334_Chip-Seq_Bcells_Human0.89845415
135MYB_21317192_ChIP-Seq_ERMYB_Mouse0.89773649
136LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.89055366
137CTCF_21964334_ChIP-Seq_BJAB-B_Human0.88810654
138BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.88427900
139* FOXA2_19822575_ChIP-Seq_HepG2_Human0.88044384
140ELF1_20517297_ChIP-Seq_JURKAT_Human0.87699457
141FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.87025820

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue5.71998665
2MP0002837_dystrophic_cardiac_calcinosis5.39065292
3MP0004084_abnormal_cardiac_muscle4.78697807
4MP0004215_abnormal_myocardial_fiber4.63292412
5MP0000751_myopathy4.14941772
6MP0005330_cardiomyopathy3.56212949
7MP0004036_abnormal_muscle_relaxation3.45467295
8MP0004130_abnormal_muscle_cell3.07896881
9MP0003436_decreased_susceptibility_to3.04137181
10MP0000749_muscle_degeneration2.99862936
11MP0003303_peritoneal_inflammation2.80698775
12MP0002972_abnormal_cardiac_muscle2.77930862
13MP0008775_abnormal_heart_ventricle2.69562725
14MP0004087_abnormal_muscle_fiber2.67363199
15MP0002132_abnormal_respiratory_system2.59669465
16MP0004484_altered_response_of2.52681270
17MP0000750_abnormal_muscle_regeneration2.52546226
18MP0003724_increased_susceptibility_to2.49212990
19MP0010630_abnormal_cardiac_muscle2.46549880
20MP0003137_abnormal_impulse_conducting2.46113160
21MP0005385_cardiovascular_system_phenoty2.40178179
22MP0001544_abnormal_cardiovascular_syste2.40178179
23MP0005025_abnormal_response_to2.32884085
24MP0004043_abnormal_pH_regulation2.30074566
25MP0005671_abnormal_response_to2.25664730
26MP0009278_abnormal_bone_marrow2.24371131
27MP0005620_abnormal_muscle_contractility2.19460866
28MP0005000_abnormal_immune_tolerance2.19329318
29MP0000465_gastrointestinal_hemorrhage2.13577093
30MP0005451_abnormal_body_composition2.13169588
31MP0005666_abnormal_adipose_tissue2.11587815
32* MP0006036_abnormal_mitochondrial_physio2.10533547
33MP0003183_abnormal_peptide_metabolism2.08862285
34MP0005670_abnormal_white_adipose2.02733869
35MP0002419_abnormal_innate_immunity2.01674584
36MP0002420_abnormal_adaptive_immunity2.01656352
37MP0003172_abnormal_lysosome_physiology2.00760769
38MP0005464_abnormal_platelet_physiology1.98510411
39MP0002106_abnormal_muscle_physiology1.98116563
40MP0003828_pulmonary_edema1.97804615
41MP0001819_abnormal_immune_cell1.97613579
42MP0002723_abnormal_immune_serum1.96959501
43MP0005397_hematopoietic_system_phenotyp1.96795202
44MP0001545_abnormal_hematopoietic_system1.96795202
45MP0004147_increased_porphyrin_level1.94447624
46MP0006138_congestive_heart_failure1.89498376
47MP0002452_abnormal_antigen_presenting1.88003648
48MP0002398_abnormal_bone_marrow1.87603313
49MP0002269_muscular_atrophy1.84713792
50MP0003221_abnormal_cardiomyocyte_apopto1.71708938
51MP0009785_altered_susceptibility_to1.67121313
52MP0000747_muscle_weakness1.66962089
53MP0009333_abnormal_splenocyte_physiolog1.64980956
54MP0000716_abnormal_immune_system1.64790104
55MP0004085_abnormal_heartbeat1.64753139
56MP0004947_skin_inflammation1.54320573
57MP0004510_myositis1.49895161
58MP0000689_abnormal_spleen_morphology1.48556473
59MP0002722_abnormal_immune_system1.48281991
60MP0005369_muscle_phenotype1.48111111
61MP0002148_abnormal_hypersensitivity_rea1.46888881
62MP0005310_abnormal_salivary_gland1.46715118
63MP0002405_respiratory_system_inflammati1.43859972
64MP0000343_altered_response_to1.43458267
65MP0004233_abnormal_muscle_weight1.42965280
66MP0002009_preneoplasia1.42366218
67MP0003656_abnormal_erythrocyte_physiolo1.40444551
68MP0000759_abnormal_skeletal_muscle1.39754271
69MP0008260_abnormal_autophagy1.38717987
70MP0002429_abnormal_blood_cell1.37413666
71MP0000703_abnormal_thymus_morphology1.33384513
72MP0005165_increased_susceptibility_to1.32862004
73MP0004185_abnormal_adipocyte_glucose1.32237866
74MP0009643_abnormal_urine_homeostasis1.30668342
75MP0001845_abnormal_inflammatory_respons1.29821709
76MP0005375_adipose_tissue_phenotype1.27022926
77MP0002127_abnormal_cardiovascular_syste1.26371703
78MP0005332_abnormal_amino_acid1.24567481
79MP0001853_heart_inflammation1.24232482
80MP0001533_abnormal_skeleton_physiology1.21816411
81MP0006082_CNS_inflammation1.18906689
82MP0001765_abnormal_ion_homeostasis1.18873218
83MP0003300_gastrointestinal_ulcer1.15906388
84MP0008961_abnormal_basal_metabolism1.14735438
85MP0003279_aneurysm1.11988685
86MP0001873_stomach_inflammation1.08348737
87MP0000266_abnormal_heart_morphology1.07895108
88MP0005075_abnormal_melanosome_morpholog1.06714417
89MP0002006_tumorigenesis1.04941391
90MP0008469_abnormal_protein_level1.03855638
91MP0006035_abnormal_mitochondrial_morpho1.02623198
92MP0001851_eye_inflammation1.00624215
93MP0004808_abnormal_hematopoietic_stem0.98963200
94MP0003075_altered_response_to0.98289396
95MP0004381_abnormal_hair_follicle0.98199229
96MP0003566_abnormal_cell_adhesion0.97912927
97MP0003690_abnormal_glial_cell0.97542602
98MP0003567_abnormal_fetal_cardiomyocyte0.97537541
99MP0004264_abnormal_extraembryonic_tissu0.96743684
100MP0006054_spinal_hemorrhage0.96696318
101MP0002909_abnormal_adrenal_gland0.95955798
102MP0002166_altered_tumor_susceptibility0.95488298
103MP0001958_emphysema0.95358269
104MP0000230_abnormal_systemic_arterial0.95147564
105MP0005584_abnormal_enzyme/coenzyme_acti0.91086374
106MP0001664_abnormal_digestion0.89936107
107MP0000681_abnormal_thyroid_gland0.89474316
108MP0002136_abnormal_kidney_physiology0.89156284
109MP0003879_abnormal_hair_cell0.88387424
110MP0005377_hearing/vestibular/ear_phenot0.86258435
111MP0003878_abnormal_ear_physiology0.86258435
112MP0002933_joint_inflammation0.86109620
113MP0002998_abnormal_bone_remodeling0.84984469
114MP0005636_abnormal_mineral_homeostasis0.83706394
115MP0005319_abnormal_enzyme/_coenzyme0.83503854
116MP0003806_abnormal_nucleotide_metabolis0.79960551
117MP0003329_amyloid_beta_deposits0.78130628
118MP0002971_abnormal_brown_adipose0.76807871
119MP0001756_abnormal_urination0.76640379
120MP0005083_abnormal_biliary_tract0.76262155
121MP0001666_abnormal_nutrient_absorption0.75587903
122MP0000604_amyloidosis0.75025297
123MP0008995_early_reproductive_senescence0.74513759
124MP0002128_abnormal_blood_circulation0.73679119
125MP0008569_lethality_at_weaning0.73654729
126MP0000249_abnormal_blood_vessel0.73620402
127MP0005410_abnormal_fertilization0.72777165
128MP0005058_abnormal_lysosome_morphology0.72648701
129MP0009840_abnormal_foam_cell0.72219922
130MP0008004_abnormal_stomach_pH0.70164007
131MP0001986_abnormal_taste_sensitivity0.69199800
132MP0008874_decreased_physiological_sensi0.68659499
133MP0004145_abnormal_muscle_electrophysio0.68421603
134MP0009780_abnormal_chondrocyte_physiolo0.67667769
135MP0000490_abnormal_crypts_of0.67622326
136MP0000678_abnormal_parathyroid_gland0.65992239
137MP0009384_cardiac_valve_regurgitation0.65119852
138MP0010329_abnormal_lipoprotein_level0.64926562
139MP0002396_abnormal_hematopoietic_system0.64018007
140MP0003191_abnormal_cellular_cholesterol0.61349416
141MP0001879_abnormal_lymphatic_vessel0.59910745
142MP0003186_abnormal_redox_activity0.57004106
143MP0000685_abnormal_immune_system0.53580101
144MP0003866_abnormal_defecation0.53234763
145MP0005360_urolithiasis0.52551212
146MP0000767_abnormal_smooth_muscle0.51821658
147MP0010155_abnormal_intestine_physiology0.50055053
148* MP0002078_abnormal_glucose_homeostasis0.50007212
149MP0003950_abnormal_plasma_membrane0.49879952
150MP0001663_abnormal_digestive_system0.49497607
151MP0005387_immune_system_phenotype0.49344216
152MP0001790_abnormal_immune_system0.49344216
153MP0009115_abnormal_fat_cell0.49150361
154MP0000003_abnormal_adipose_tissue0.48867715
155MP0003763_abnormal_thymus_physiology0.48040686
156* MP0005266_abnormal_metabolism0.46882858
157MP0001835_abnormal_antigen_presentation0.46753792
158MP0002138_abnormal_hepatobiliary_system0.46451616
159MP0003045_fibrosis0.46222045
160MP0005334_abnormal_fat_pad0.45896403
161MP0005166_decreased_susceptibility_to0.44084816
162MP0001784_abnormal_fluid_regulation0.43763761
163* MP0002118_abnormal_lipid_homeostasis0.43188381
164MP0001800_abnormal_humoral_immune0.42480319

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)6.23585686
2Ventricular tachycardia (HP:0004756)6.01082814
3Atrial fibrillation (HP:0005110)4.97088454
4Myoglobinuria (HP:0002913)4.92111153
5Calf muscle hypertrophy (HP:0008981)4.77376888
6Exercise-induced myalgia (HP:0003738)4.67848196
7Primary atrial arrhythmia (HP:0001692)4.63409501
8Exercise-induced muscle cramps (HP:0003710)4.56846520
9Supraventricular tachycardia (HP:0004755)4.52184160
10Panhypogammaglobulinemia (HP:0003139)4.46959880
11Supraventricular arrhythmia (HP:0005115)4.41321156
12Bundle branch block (HP:0011710)4.38303545
13Lipoatrophy (HP:0100578)4.31224673
14Eczematoid dermatitis (HP:0000976)4.29099006
15Muscle fiber splitting (HP:0003555)4.23401868
16Right ventricular cardiomyopathy (HP:0011663)4.19697008
17Muscle hypertrophy of the lower extremities (HP:0008968)4.18484863
18Syncope (HP:0001279)4.04128134
19Palpitations (HP:0001962)4.01452430
20Ketoacidosis (HP:0001993)3.90866581
21Prolonged bleeding time (HP:0003010)3.86673271
22Asymmetric septal hypertrophy (HP:0001670)3.82488755
23Abnormality of the calf musculature (HP:0001430)3.81183843
24Heart block (HP:0012722)3.79684736
25Dilated cardiomyopathy (HP:0001644)3.79570962
26Atrioventricular block (HP:0001678)3.71967530
27Rhabdomyolysis (HP:0003201)3.62785415
28Meningitis (HP:0001287)3.59279531
29Hyperglycinuria (HP:0003108)3.57881859
30Prolonged QT interval (HP:0001657)3.54323700
31Hyporeflexia of lower limbs (HP:0002600)3.53813774
32Abnormality of fatty-acid metabolism (HP:0004359)3.50423762
33Abnormal atrioventricular conduction (HP:0005150)3.48528924
34Subaortic stenosis (HP:0001682)3.42242936
35Abnormality of the left ventricular outflow tract (HP:0011103)3.42242936
36Recurrent abscess formation (HP:0002722)3.40029909
37Hepatic necrosis (HP:0002605)3.35946070
38Cellulitis (HP:0100658)3.35888852
39Ventricular arrhythmia (HP:0004308)3.30597605
40Abnormal delayed hypersensitivity skin test (HP:0002963)3.30044003
41Recurrent fungal infections (HP:0002841)3.29941261
42Dicarboxylic aciduria (HP:0003215)3.26875091
43Abnormality of dicarboxylic acid metabolism (HP:0010995)3.26875091
44Recurrent bacterial skin infections (HP:0005406)3.15106710
45Increased IgE level (HP:0003212)3.14717098
46Recurrent viral infections (HP:0004429)3.14247606
47Myositis (HP:0100614)3.12866464
48Gastrointestinal inflammation (HP:0004386)3.11036566
49Abnormality of the heme biosynthetic pathway (HP:0010472)3.06779388
50Elevated erythrocyte sedimentation rate (HP:0003565)3.04724669
51Chronic obstructive pulmonary disease (HP:0006510)3.03496095
52Obstructive lung disease (HP:0006536)3.03496095
53Ventricular fibrillation (HP:0001663)3.02595339
54Nasal polyposis (HP:0100582)2.98537518
55Hypoglycemic coma (HP:0001325)2.96774416
56Inflammation of the large intestine (HP:0002037)2.96121540
57Generalized aminoaciduria (HP:0002909)2.96016254
58Mediastinal lymphadenopathy (HP:0100721)2.91919703
59Ketosis (HP:0001946)2.88672264
60Difficulty running (HP:0009046)2.88448000
61Recurrent gram-negative bacterial infections (HP:0005420)2.87204731
62Increased connective tissue (HP:0009025)2.85275918
63EMG: myopathic abnormalities (HP:0003458)2.81880464
64Gastrointestinal infarctions (HP:0005244)2.81194171
65Hepatocellular necrosis (HP:0001404)2.79357453
66Abnormal mitochondria in muscle tissue (HP:0008316)2.79156892
67Abnormality of alanine metabolism (HP:0010916)2.78271209
68Hyperalaninemia (HP:0003348)2.78271209
69Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.78271209
70Conjunctival hamartoma (HP:0100780)2.77991356
71Abnormality of glycine metabolism (HP:0010895)2.76850307
72Abnormality of serine family amino acid metabolism (HP:0010894)2.76850307
73Increased muscle lipid content (HP:0009058)2.75381952
74Recurrent sinusitis (HP:0011108)2.74377816
75Abnormality of the nasal mucosa (HP:0000433)2.72721146
76Recurrent bronchitis (HP:0002837)2.70950045
77Petechiae (HP:0000967)2.69966818
78Abnormality of B cell number (HP:0010975)2.66587422
79Epistaxis (HP:0000421)2.64974592
80Proximal tubulopathy (HP:0000114)2.62414743
81Granulocytopenia (HP:0001913)2.61814041
82Abnormality of macrophages (HP:0004311)2.60103519
83Gout (HP:0001997)2.58793588
84Acute necrotizing encephalopathy (HP:0006965)2.58422760
85Encephalitis (HP:0002383)2.57561940
86Acute encephalopathy (HP:0006846)2.57547299
87Nausea (HP:0002018)2.53510260
88B lymphocytopenia (HP:0010976)2.52471722
89Vasculitis (HP:0002633)2.48616485
90Purpura (HP:0000979)2.46643681
91Chronic mucocutaneous candidiasis (HP:0002728)2.45705218
92Recurrent cutaneous fungal infections (HP:0011370)2.45705218
93Hyperammonemia (HP:0001987)2.45374787
94Chronic otitis media (HP:0000389)2.44092151
95Recurrent skin infections (HP:0001581)2.43971092
96Abnormality of the fingertips (HP:0001211)2.43477975
97Gingivitis (HP:0000230)2.43336739
98Limb-girdle muscle atrophy (HP:0003797)2.43123618
99Abnormal EKG (HP:0003115)2.43039744
100Hypoplasia of the thymus (HP:0000778)2.40863777
101Spontaneous hematomas (HP:0007420)2.33847414
102Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.33845671
103Chest pain (HP:0100749)2.33501692
104Papilledema (HP:0001085)2.33442514
105Polycythemia (HP:0001901)2.33276925
106Orchitis (HP:0100796)2.32130608
107Lactic acidosis (HP:0003128)2.27857225
108Osteomyelitis (HP:0002754)2.27592568
109Abnormality of T cells (HP:0002843)2.27461195
110Cerebral edema (HP:0002181)2.27289352
111Facial diplegia (HP:0001349)2.26672983
112Myotonia (HP:0002486)2.26251498
113T lymphocytopenia (HP:0005403)2.24954783
114Esophageal neoplasm (HP:0100751)2.24323784
115Neoplasm of head and neck (HP:0012288)2.24323784
116Polyuria (HP:0000103)2.23122309
117Abnormal urine output (HP:0012590)2.21988190
118Increased intramyocellular lipid droplets (HP:0012240)2.21976996
119Respiratory failure (HP:0002878)2.21888371
120Left ventricular hypertrophy (HP:0001712)2.20950977
121Verrucae (HP:0200043)2.19167314
122Papilloma (HP:0012740)2.19167314
123Mitochondrial inheritance (HP:0001427)2.19093789
124Progressive macrocephaly (HP:0004481)2.18169956
125Hyperactive renin-angiotensin system (HP:0000841)2.17966965
126Increased CSF lactate (HP:0002490)2.17942521
127Stomatitis (HP:0010280)2.17350188
128Seborrheic dermatitis (HP:0001051)2.16884585
129Hamartoma of the eye (HP:0010568)2.15427573
130Hypochromic anemia (HP:0001931)2.15418146
131Ankle clonus (HP:0011448)2.15187392
132Palmoplantar keratoderma (HP:0000982)2.14173617
133Abnormality of renal excretion (HP:0011036)2.13594059
134Recurrent otitis media (HP:0000403)2.13093977
135Diaphragmatic weakness (HP:0009113)2.12956270
136Testicular atrophy (HP:0000029)2.12758679
137Increased circulating renin level (HP:0000848)2.10566141
138Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.10507048
139Abnormality of T cell number (HP:0011839)2.10210438
140Gingival bleeding (HP:0000225)2.09061719
141Metabolic acidosis (HP:0001942)2.09034882
142Slow saccadic eye movements (HP:0000514)2.06823985
143Chronic sinusitis (HP:0011109)2.06676972
144Optic neuritis (HP:0100653)2.05863124
145Retrobulbar optic neuritis (HP:0100654)2.05863124
146Pustule (HP:0200039)2.05112867
147Abnormality of T cell physiology (HP:0011840)2.04308808
148Centrally nucleated skeletal muscle fibers (HP:0003687)2.04297800
149Chronic diarrhea (HP:0002028)2.03812754
150Hypokalemic alkalosis (HP:0001949)2.02026737
151Absent/shortened dynein arms (HP:0200106)2.02008384
152Dynein arm defect of respiratory motile cilia (HP:0012255)2.02008384
153Multiple enchondromatosis (HP:0005701)2.02004516
154Athetosis (HP:0002305)2.01802781
155Increased purine levels (HP:0004368)2.01479849
156Hyperuricemia (HP:0002149)2.01479849
157Malnutrition (HP:0004395)2.01360558
158Autoimmune hemolytic anemia (HP:0001890)2.00276639
159Eosinophilia (HP:0001880)2.00141288
160Bronchitis (HP:0012387)1.99849365
161Difficulty climbing stairs (HP:0003551)1.98607796
162Leukocytosis (HP:0001974)1.98429692
163Ragged-red muscle fibers (HP:0003200)1.97579896
164Severe combined immunodeficiency (HP:0004430)1.97116693
165Sepsis (HP:0100806)1.96507883
166Mesangial abnormality (HP:0001966)1.96443744
167Distal lower limb muscle weakness (HP:0009053)1.96308380
168Urticaria (HP:0001025)1.96161342
169Cerebral palsy (HP:0100021)1.95283524
170Vomiting (HP:0002013)1.94876808
171Sudden cardiac death (HP:0001645)1.94586498
172Testicular neoplasm (HP:0010788)1.94080468
173Metabolic alkalosis (HP:0200114)1.92767730
174Gastrointestinal stroma tumor (HP:0100723)1.92149329
175Hypertensive crisis (HP:0100735)1.91834607
176Colitis (HP:0002583)1.91133083
177Reticulocytosis (HP:0001923)1.90929563
178Agammaglobulinemia (HP:0004432)1.90335930
179Systemic lupus erythematosus (HP:0002725)1.88060651
180Growth hormone excess (HP:0000845)1.86453159
181Abnormality of iron homeostasis (HP:0011031)1.85414085
182Skin rash (HP:0000988)1.84407610
183Increased serum ferritin (HP:0003281)1.84406788
184Viral hepatitis (HP:0006562)1.82484124
185Bronchiectasis (HP:0002110)1.81132059
186Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.80445646

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LMTK24.97991265
2TTN4.63283457
3PRPF4B3.99350956
4RIPK43.73180748
5TRIB33.69133155
6PDK33.41490885
7PDK43.41490885
8PHKG13.34612004
9PHKG23.34612004
10BCKDK3.07914289
11PKN22.90463875
12MYLK2.68827493
13WNK42.54775158
14TNK22.51632495
15PDK22.21844733
16DMPK2.01317920
17FES1.97523887
18MAP3K131.85179693
19OBSCN1.82686617
20NEK11.82574930
21MAP3K111.77479915
22PIK3CA1.75793770
23TESK21.73325264
24EEF2K1.69826633
25BLK1.68948895
26MAP4K11.68385919
27PINK11.63199820
28LRRK21.62096256
29MAP3K101.62009026
30TGFBR21.59228878
31SMG11.56582217
32TIE11.52713357
33MARK21.42049362
34TAOK11.38456126
35STK241.36971546
36STK391.35653407
37MAPK121.35613870
38ERN11.34310598
39STK41.33932746
40SIK11.25701006
41STK101.24974570
42IRAK41.22471752
43IKBKE1.20929931
44TAOK31.19889896
45MAP3K71.19056283
46MAP3K11.15073214
47MAPK151.13884427
48TYK21.11664935
49GRK71.10081545
50PRKD11.05898267
51HCK1.04422094
52TXK1.03960487
53GRK61.02880517
54NME21.02120763
55TAOK21.01002903
56SIK20.98046913
57MAPKAPK30.97804600
58LYN0.96737959
59OXSR10.96383639
60MAP2K20.95773682
61CAMKK10.94378705
62LCK0.93278774
63MUSK0.93107977
64HIPK20.91829497
65MAP3K30.89033633
66MST40.89001217
67PRKAA10.87635305
68CAMK1D0.87197344
69MAP3K140.85614351
70PAK30.84242944
71PRKAA20.84182677
72TEC0.79952536
73PRKD20.79448813
74KSR20.77624258
75JAK10.76952191
76ILK0.75355903
77RIPK10.72690035
78DYRK1B0.72653745
79SGK30.72425547
80PTK60.70405410
81FLT30.69280740
82RET0.66764190
83PDGFRA0.65886726
84CDC42BPA0.65239186
85MAP2K30.64933009
86EPHB10.62068119
87MAP2K60.61751390
88MATK0.61231539
89DAPK20.60922042
90PDK10.60848070
91IKBKB0.60062074
92MAPK110.58233358
93RPS6KA20.57495005
94STK380.57136726
95BMPR20.57067673
96PRKD30.56952413
97PDPK10.56713875
98TESK10.56555788
99WNK10.56319016
100TRPM70.56245444
101CAMK40.55271077
102MAPK40.53100717
103FYN0.52537228
104WNK30.52468348
105ROCK10.52418057
106SCYL20.52247769
107CAMK2D0.50116812
108CSF1R0.50093915
109CDK40.49021243
110UHMK10.48347380
111FGFR30.47801419
112JAK20.47612464
113PIM10.47147447
114SYK0.46168811
115RPS6KL10.45866341
116RPS6KC10.45866341
117FGFR40.45657545
118BTK0.45611125
119MARK30.45056592
120PIK3CG0.43715704
121CAMK1G0.41790472
122MAPK30.41544979
123ITK0.40249712
124RPS6KA60.39786586
125SGK20.39260167
126STK110.39040787
127TBK10.38798405
128AKT20.38450399
129IRAK30.38130217
130JAK30.37804881
131KDR0.37477106
132CDK120.37230292
133CAMK10.36325709
134CSK0.36286690
135PRKCH0.36078715
136NEK60.35302013
137ZAP700.35057461
138PRKCQ0.34481839
139ICK0.33880482
140RPS6KB20.33421969
141MAPK70.33104586
142PDGFRB0.33020985
143NEK90.31413898
144STK38L0.30783773
145PRKACG0.29198966
146KIT0.27566191
147RPS6KA10.27429853
148ROCK20.26835326
149PRKACB0.23152044
150MAP3K50.22415751

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000206.38595620
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012104.68758231
3Fatty acid degradation_Homo sapiens_hsa000713.78618206
4* Propanoate metabolism_Homo sapiens_hsa006403.75028584
5Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.12456298
6Fatty acid metabolism_Homo sapiens_hsa012122.94193727
7Cardiac muscle contraction_Homo sapiens_hsa042602.89285827
8Allograft rejection_Homo sapiens_hsa053302.59302371
9* Carbon metabolism_Homo sapiens_hsa012002.54593183
10Graft-versus-host disease_Homo sapiens_hsa053322.51673734
11Autoimmune thyroid disease_Homo sapiens_hsa053202.46145866
12Parkinsons disease_Homo sapiens_hsa050122.42387075
13Dilated cardiomyopathy_Homo sapiens_hsa054142.31407014
14Oxidative phosphorylation_Homo sapiens_hsa001902.29090547
15Leishmaniasis_Homo sapiens_hsa051402.27643897
16Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.24984414
17Staphylococcus aureus infection_Homo sapiens_hsa051502.02359263
18Asthma_Homo sapiens_hsa053101.95978695
19Intestinal immune network for IgA production_Homo sapiens_hsa046721.92698741
20Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.91377568
21Type I diabetes mellitus_Homo sapiens_hsa049401.90664106
22Fatty acid biosynthesis_Homo sapiens_hsa000611.87546674
23Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.82780675
24Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.82403947
25* Pyruvate metabolism_Homo sapiens_hsa006201.78266349
26Alzheimers disease_Homo sapiens_hsa050101.68831159
27Antigen processing and presentation_Homo sapiens_hsa046121.67124991
28Butanoate metabolism_Homo sapiens_hsa006501.64503839
29Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.52643457
30Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.52219108
31Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.49607724
32PPAR signaling pathway_Homo sapiens_hsa033201.46542082
33Viral myocarditis_Homo sapiens_hsa054161.41798965
34Lysine degradation_Homo sapiens_hsa003101.40796656
35Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.37876338
36Tuberculosis_Homo sapiens_hsa051521.35591041
37Huntingtons disease_Homo sapiens_hsa050161.32318537
38T cell receptor signaling pathway_Homo sapiens_hsa046601.30835348
39Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.27196547
40Insulin resistance_Homo sapiens_hsa049311.22246237
41beta-Alanine metabolism_Homo sapiens_hsa004101.21749280
42Influenza A_Homo sapiens_hsa051641.17055132
43Adipocytokine signaling pathway_Homo sapiens_hsa049201.14384512
44Glycerophospholipid metabolism_Homo sapiens_hsa005641.12831928
45Cyanoamino acid metabolism_Homo sapiens_hsa004601.10043311
46Biosynthesis of amino acids_Homo sapiens_hsa012301.09353658
47Phosphatidylinositol signaling system_Homo sapiens_hsa040701.08353746
48Toll-like receptor signaling pathway_Homo sapiens_hsa046201.01992641
49Jak-STAT signaling pathway_Homo sapiens_hsa046301.01578322
50Primary immunodeficiency_Homo sapiens_hsa053401.00784081
51Herpes simplex infection_Homo sapiens_hsa051681.00638159
52Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.00019418
53Measles_Homo sapiens_hsa051620.99565261
54NF-kappa B signaling pathway_Homo sapiens_hsa040640.97319098
55Fatty acid elongation_Homo sapiens_hsa000620.96499959
56Hepatitis C_Homo sapiens_hsa051600.95246099
57Peroxisome_Homo sapiens_hsa041460.95237337
58Chemokine signaling pathway_Homo sapiens_hsa040620.94670664
59Tryptophan metabolism_Homo sapiens_hsa003800.92269442
60* Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.91158544
61Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.89220976
62RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.85660566
63Aldosterone synthesis and secretion_Homo sapiens_hsa049250.85087678
64Choline metabolism in cancer_Homo sapiens_hsa052310.83340091
65Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.82695873
66GnRH signaling pathway_Homo sapiens_hsa049120.82333036
67B cell receptor signaling pathway_Homo sapiens_hsa046620.81240271
68Long-term potentiation_Homo sapiens_hsa047200.80068962
69Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.79847921
70Histidine metabolism_Homo sapiens_hsa003400.79466836
71Starch and sucrose metabolism_Homo sapiens_hsa005000.78651877
72Gastric acid secretion_Homo sapiens_hsa049710.78466803
73Pancreatic cancer_Homo sapiens_hsa052120.78364921
74Insulin signaling pathway_Homo sapiens_hsa049100.77115707
75Hepatitis B_Homo sapiens_hsa051610.75800064
76Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.72815831
77Renin secretion_Homo sapiens_hsa049240.72366696
78Neurotrophin signaling pathway_Homo sapiens_hsa047220.71707336
79Arginine and proline metabolism_Homo sapiens_hsa003300.71524236
80Phospholipase D signaling pathway_Homo sapiens_hsa040720.71382631
81Prolactin signaling pathway_Homo sapiens_hsa049170.69042493
82AMPK signaling pathway_Homo sapiens_hsa041520.68951502
83Sulfur relay system_Homo sapiens_hsa041220.65553593
84Fructose and mannose metabolism_Homo sapiens_hsa000510.65493881
85Glucagon signaling pathway_Homo sapiens_hsa049220.65492004
86Glycerolipid metabolism_Homo sapiens_hsa005610.63377028
87Malaria_Homo sapiens_hsa051440.63286778
88Thyroid hormone signaling pathway_Homo sapiens_hsa049190.62065527
89Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.62064569
90Galactose metabolism_Homo sapiens_hsa000520.61537117
91TNF signaling pathway_Homo sapiens_hsa046680.61038687
92cGMP-PKG signaling pathway_Homo sapiens_hsa040220.60827939
93Other glycan degradation_Homo sapiens_hsa005110.60719316
94Nitrogen metabolism_Homo sapiens_hsa009100.60059426
95Endocytosis_Homo sapiens_hsa041440.59769702
96Glycosaminoglycan degradation_Homo sapiens_hsa005310.58958803
97Leukocyte transendothelial migration_Homo sapiens_hsa046700.57828179
98Sphingolipid signaling pathway_Homo sapiens_hsa040710.57207043
99Estrogen signaling pathway_Homo sapiens_hsa049150.56945224
100Salivary secretion_Homo sapiens_hsa049700.56590911
101Endometrial cancer_Homo sapiens_hsa052130.56390898
102Pentose phosphate pathway_Homo sapiens_hsa000300.56088912
103Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.54864477
104African trypanosomiasis_Homo sapiens_hsa051430.54840698
105Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.54109873
106alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.52921350
107Mineral absorption_Homo sapiens_hsa049780.52759714
108Caffeine metabolism_Homo sapiens_hsa002320.51646575
109HIF-1 signaling pathway_Homo sapiens_hsa040660.51612540
110Vascular smooth muscle contraction_Homo sapiens_hsa042700.49869105
111Arachidonic acid metabolism_Homo sapiens_hsa005900.49755340
112Transcriptional misregulation in cancer_Homo sapiens_hsa052020.49136175
113NOD-like receptor signaling pathway_Homo sapiens_hsa046210.48302067
114Pertussis_Homo sapiens_hsa051330.46779116
115Ovarian steroidogenesis_Homo sapiens_hsa049130.46777672
116Oxytocin signaling pathway_Homo sapiens_hsa049210.45885617
117Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.44942130
118Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.44467607
119Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.42233146
120HTLV-I infection_Homo sapiens_hsa051660.41869625
121Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.40622863
122Toxoplasmosis_Homo sapiens_hsa051450.40364966
123Carbohydrate digestion and absorption_Homo sapiens_hsa049730.39169946
124Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.39161996
125Bile secretion_Homo sapiens_hsa049760.39051477
126Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.36361976
127Sulfur metabolism_Homo sapiens_hsa009200.36109109
128Renin-angiotensin system_Homo sapiens_hsa046140.34099223
129Small cell lung cancer_Homo sapiens_hsa052220.34044293
130Focal adhesion_Homo sapiens_hsa045100.32285444
131Central carbon metabolism in cancer_Homo sapiens_hsa052300.30490434
132Longevity regulating pathway - mammal_Homo sapiens_hsa042110.29716300
133* Metabolic pathways_Homo sapiens_hsa011000.29539387
134Osteoclast differentiation_Homo sapiens_hsa043800.27845210
135Pancreatic secretion_Homo sapiens_hsa049720.27616458
136Platelet activation_Homo sapiens_hsa046110.27006807
137Arginine biosynthesis_Homo sapiens_hsa002200.26892626
138Glutathione metabolism_Homo sapiens_hsa004800.26579835
139Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.26144959
140Calcium signaling pathway_Homo sapiens_hsa040200.24436484
141ABC transporters_Homo sapiens_hsa020100.23790574
142Inositol phosphate metabolism_Homo sapiens_hsa005620.22849457
143Protein digestion and absorption_Homo sapiens_hsa049740.22587197
144Hematopoietic cell lineage_Homo sapiens_hsa046400.22068282
145AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.21962013
146Acute myeloid leukemia_Homo sapiens_hsa052210.21816518
147Pentose and glucuronate interconversions_Homo sapiens_hsa000400.20502190
148FoxO signaling pathway_Homo sapiens_hsa040680.19774399
149Adherens junction_Homo sapiens_hsa045200.19113950
150VEGF signaling pathway_Homo sapiens_hsa043700.18890226
151mTOR signaling pathway_Homo sapiens_hsa041500.17122786
152Non-small cell lung cancer_Homo sapiens_hsa052230.17056358
153Vitamin digestion and absorption_Homo sapiens_hsa049770.15713458
154Fat digestion and absorption_Homo sapiens_hsa049750.14997491
155Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.14647552
156cAMP signaling pathway_Homo sapiens_hsa040240.14449226
157Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.13634957
158Chronic myeloid leukemia_Homo sapiens_hsa052200.13124186
159Notch signaling pathway_Homo sapiens_hsa043300.12203353

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