ACSS2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a cytosolic enzyme that catalyzes the activation of acetate for use in lipid synthesis and energy generation. The protein acts as a monomer and produces acetyl-CoA from acetate in a reaction that requires ATP. Expression of this gene is regulated by sterol regulatory element-binding proteins, transcription factors that activate genes required for the synthesis of cholesterol and unsaturated fatty acids. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.01773184
2L-phenylalanine catabolic process (GO:0006559)7.01773184
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.65541040
4L-phenylalanine metabolic process (GO:0006558)6.65541040
5low-density lipoprotein particle clearance (GO:0034383)6.17027111
6aromatic amino acid family catabolic process (GO:0009074)6.10314467
7alpha-linolenic acid metabolic process (GO:0036109)5.92726398
8NADH metabolic process (GO:0006734)5.75153811
9triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.35946384
10glyoxylate metabolic process (GO:0046487)5.30390098
11tryptophan catabolic process (GO:0006569)5.29026544
12indole-containing compound catabolic process (GO:0042436)5.29026544
13indolalkylamine catabolic process (GO:0046218)5.29026544
14bile acid biosynthetic process (GO:0006699)5.25416052
15fatty acid homeostasis (GO:0055089)5.21882105
16cysteine metabolic process (GO:0006534)5.20619923
17kynurenine metabolic process (GO:0070189)5.06169774
18sulfur amino acid catabolic process (GO:0000098)5.02809421
19tryptophan metabolic process (GO:0006568)4.98052316
20fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.85324508
21lysine metabolic process (GO:0006553)4.72477739
22lysine catabolic process (GO:0006554)4.72477739
23diacylglycerol metabolic process (GO:0046339)4.71174238
24urea cycle (GO:0000050)4.68595988
25urea metabolic process (GO:0019627)4.68595988
26* acetyl-CoA metabolic process (GO:0006084)4.50516813
27bile acid metabolic process (GO:0008206)4.49975067
28serine family amino acid catabolic process (GO:0009071)4.47155273
29high-density lipoprotein particle remodeling (GO:0034375)4.46432582
30triglyceride biosynthetic process (GO:0019432)4.44356163
31regulation of triglyceride catabolic process (GO:0010896)4.42554608
32complement activation, alternative pathway (GO:0006957)4.39959028
33aromatic amino acid family metabolic process (GO:0009072)4.39497564
34triglyceride catabolic process (GO:0019433)4.39142768
35nitrogen cycle metabolic process (GO:0071941)4.35707974
36amino-acid betaine metabolic process (GO:0006577)4.35676505
37homocysteine metabolic process (GO:0050667)4.33073510
38tyrosine metabolic process (GO:0006570)4.31476026
39alpha-amino acid catabolic process (GO:1901606)4.28597009
40acylglycerol biosynthetic process (GO:0046463)4.26480552
41neutral lipid biosynthetic process (GO:0046460)4.26480552
42cellular ketone body metabolic process (GO:0046950)4.26381252
43protein carboxylation (GO:0018214)4.25723001
44peptidyl-glutamic acid carboxylation (GO:0017187)4.25723001
45intestinal absorption (GO:0050892)4.25217040
46negative regulation of fibrinolysis (GO:0051918)4.23017467
47coenzyme catabolic process (GO:0009109)4.22981697
48oxaloacetate metabolic process (GO:0006107)4.22283442
49neutral lipid catabolic process (GO:0046461)4.20474194
50acylglycerol catabolic process (GO:0046464)4.20474194
51tricarboxylic acid metabolic process (GO:0072350)4.19503196
52plasma lipoprotein particle clearance (GO:0034381)4.17550198
53triglyceride homeostasis (GO:0070328)4.12061779
54acylglycerol homeostasis (GO:0055090)4.12061779
55regulation of protein activation cascade (GO:2000257)4.09996936
56regulation of fibrinolysis (GO:0051917)4.06826068
57* short-chain fatty acid metabolic process (GO:0046459)4.05394016
58fatty-acyl-CoA biosynthetic process (GO:0046949)4.04450622
59cellular amino acid catabolic process (GO:0009063)4.04271603
60regulation of cholesterol esterification (GO:0010872)4.03648524
61glutamate metabolic process (GO:0006536)3.99007251
62fatty acid beta-oxidation (GO:0006635)3.95927039
63reverse cholesterol transport (GO:0043691)3.91396989
64plasma lipoprotein particle remodeling (GO:0034369)3.90228658
65protein-lipid complex remodeling (GO:0034368)3.90228658
66macromolecular complex remodeling (GO:0034367)3.90228658
67regulation of cholesterol storage (GO:0010885)3.88074859
68long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.86901007
69cellular modified amino acid catabolic process (GO:0042219)3.85299410
70very long-chain fatty acid metabolic process (GO:0000038)3.84905007
71negative regulation of sterol transport (GO:0032372)3.84669878
72negative regulation of cholesterol transport (GO:0032375)3.84669878
73fatty acid oxidation (GO:0019395)3.84626591
74drug transmembrane transport (GO:0006855)3.83897614
75drug catabolic process (GO:0042737)3.83508578
76protein-lipid complex assembly (GO:0065005)3.82989979
77regulation of complement activation (GO:0030449)3.82752979
78biotin metabolic process (GO:0006768)3.80690998
79fatty acid catabolic process (GO:0009062)3.79212923
80lipid oxidation (GO:0034440)3.78895408
81aspartate family amino acid catabolic process (GO:0009068)3.76942274
82long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.75641453
83indolalkylamine metabolic process (GO:0006586)3.75309664
84monocarboxylic acid catabolic process (GO:0072329)3.73959187
85triglyceride metabolic process (GO:0006641)3.73948570
86serine family amino acid metabolic process (GO:0009069)3.73817631
87organic acid catabolic process (GO:0016054)3.73110162
88carboxylic acid catabolic process (GO:0046395)3.73110162
89* thioester biosynthetic process (GO:0035384)3.73100949
90* acyl-CoA biosynthetic process (GO:0071616)3.73100949
91valine metabolic process (GO:0006573)3.72448825
92cellular glucuronidation (GO:0052695)3.72323898
93amine catabolic process (GO:0009310)3.70155935
94cellular biogenic amine catabolic process (GO:0042402)3.70155935
95ketone body metabolic process (GO:1902224)3.69056776
96phospholipid efflux (GO:0033700)3.68706653
97phospholipid homeostasis (GO:0055091)3.66653663
98regulation of cholesterol biosynthetic process (GO:0045540)3.65021586
99benzene-containing compound metabolic process (GO:0042537)3.63792525
100carnitine shuttle (GO:0006853)3.63708532
101* ethanol oxidation (GO:0006069)3.63254955
102regulation of sequestering of triglyceride (GO:0010889)3.62938208
103* acyl-CoA metabolic process (GO:0006637)3.62722698
104* thioester metabolic process (GO:0035383)3.62722698
105positive regulation of lipid catabolic process (GO:0050996)3.62050543
106bile acid and bile salt transport (GO:0015721)3.61825926
107linoleic acid metabolic process (GO:0043651)3.61329873
108fatty acid elongation (GO:0030497)3.61048445
109dicarboxylic acid biosynthetic process (GO:0043650)3.60648382
110positive regulation of lipoprotein lipase activity (GO:0051006)3.59248651
111positive regulation of triglyceride lipase activity (GO:0061365)3.59248651
1122-oxoglutarate metabolic process (GO:0006103)3.58453893
113cofactor catabolic process (GO:0051187)3.58369086
114acylglycerol metabolic process (GO:0006639)3.55486527
115creatine metabolic process (GO:0006600)3.54452256
116fatty-acyl-CoA metabolic process (GO:0035337)3.53891470
117cholesterol efflux (GO:0033344)3.52855875
118very-low-density lipoprotein particle assembly (GO:0034379)3.50589009
119serine family amino acid biosynthetic process (GO:0009070)3.50434845
120regulation of cholesterol homeostasis (GO:2000188)3.50302329
121positive regulation of fatty acid beta-oxidation (GO:0032000)3.49897014
122neutral lipid metabolic process (GO:0006638)3.49237848
123plasma lipoprotein particle assembly (GO:0034377)3.47700614
124regulation of cholesterol metabolic process (GO:0090181)3.46172048
125carnitine metabolic process (GO:0009437)3.45802156
126glycine metabolic process (GO:0006544)3.44807447
127aldehyde catabolic process (GO:0046185)3.43863646
128negative regulation of fatty acid biosynthetic process (GO:0045717)3.38487178
129angiotensin maturation (GO:0002003)3.38101659
130fructose metabolic process (GO:0006000)3.35423228
131fatty acid transmembrane transport (GO:1902001)3.29665410
132regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.29000522
133protein-lipid complex subunit organization (GO:0071825)3.26008277
134plasma lipoprotein particle organization (GO:0071827)3.25566068
135positive regulation of fatty acid biosynthetic process (GO:0045723)3.17430048
136lipoprotein transport (GO:0042953)3.11864768
137regulation of fatty acid biosynthetic process (GO:0042304)3.10299350
138epoxygenase P450 pathway (GO:0019373)3.09074260
139fat-soluble vitamin biosynthetic process (GO:0042362)3.08576243
140intestinal cholesterol absorption (GO:0030299)3.08103993
141low-density lipoprotein particle remodeling (GO:0034374)3.00180718
142regulation of triglyceride metabolic process (GO:0090207)2.98152057
143positive regulation of lipid storage (GO:0010884)2.97002324
144glycerolipid catabolic process (GO:0046503)2.96989110
145proline biosynthetic process (GO:0006561)2.95925681
146regulation of apoptotic cell clearance (GO:2000425)2.93162109
147positive regulation of triglyceride metabolic process (GO:0090208)2.86686322
148cholesterol homeostasis (GO:0042632)2.86187330
149lipoprotein metabolic process (GO:0042157)2.82565239
150sterol homeostasis (GO:0055092)2.81804383
151lipid storage (GO:0019915)2.80250679
152tricarboxylic acid cycle (GO:0006099)2.77553357
153regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.77510167
154glutamine family amino acid biosynthetic process (GO:0009084)2.76075017
155positive regulation of fatty acid metabolic process (GO:0045923)2.75426049

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse7.31124541
2PPARA_22158963_ChIP-Seq_LIVER_Mouse6.17000764
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.10016332
4LXR_22158963_ChIP-Seq_LIVER_Mouse5.84767823
5EGR1_23403033_ChIP-Seq_LIVER_Mouse5.68937451
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.73580921
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.03646274
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.61925630
9TP63_17297297_ChIP-ChIP_HaCaT_Human3.57622898
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.21565208
11TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.57594839
12ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.2065366
13TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.91961674
14RACK7_27058665_Chip-Seq_MCF-7_Human1.80782558
15TRIM28_21343339_ChIP-Seq_HEK293_Human1.78775125
16NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.76620903
17CLOCK_20551151_ChIP-Seq_293T_Human1.73532928
18ELK3_25401928_ChIP-Seq_HUVEC_Human1.69148910
19FOXA2_19822575_ChIP-Seq_HepG2_Human1.62178316
20TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.60654655
21HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.57557011
22KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.54426419
23CDX2_20551321_ChIP-Seq_CACO-2_Human1.53770667
24TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.52010623
25KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.50357311
26HTT_18923047_ChIP-ChIP_STHdh_Human1.48423334
27TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.37437175
28HNF4A_19822575_ChIP-Seq_HepG2_Human1.28009899
29STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.27201662
30GATA1_22025678_ChIP-Seq_K562_Human1.26196514
31PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.25979037
32VDR_21846776_ChIP-Seq_THP-1_Human1.21703182
33RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.21696614
34RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.21562272
35HIF1A_21447827_ChIP-Seq_MCF-7_Human1.20883205
36P63_26484246_Chip-Seq_KERATINOCYTES_Human1.19489766
37THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.19125625
38GATA6_25053715_ChIP-Seq_YYC3_Human1.18074490
39PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.15112289
40SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.14997303
41* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.14435899
42DNAJC2_21179169_ChIP-ChIP_NT2_Human1.14214771
43* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.13951188
44NCOR1_26117541_ChIP-Seq_K562_Human1.13610178
45UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.13223699
46GATA1_22383799_ChIP-Seq_G1ME_Mouse1.11484767
47ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.11381229
48* KDM2B_26808549_Chip-Seq_K562_Human1.10699500
49TCF7_22412390_ChIP-Seq_EML_Mouse1.09733782
50ZNF263_19887448_ChIP-Seq_K562_Human1.09187267
51* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.08372530
52NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.07316870
53EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.06062903
54TET1_21451524_ChIP-Seq_MESCs_Mouse1.05491946
55SOX2_27498859_Chip-Seq_STOMACH_Mouse1.05061754
56P300_27058665_Chip-Seq_ZR-75-30cells_Human1.04597281
57WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.04544728
58P68_20966046_ChIP-Seq_HELA_Human1.04344906
59ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.03772107
60* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.02877510
61ESR1_21235772_ChIP-Seq_MCF-7_Human1.02352245
62TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.02236791
63SMC4_20622854_ChIP-Seq_HELA_Human1.01804228
64ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.00487551
65NFIB_24661679_ChIP-Seq_LUNG_Mouse0.99137483
66ZFP281_18757296_ChIP-ChIP_E14_Mouse0.99108279
67ATF3_27146783_Chip-Seq_COLON_Human0.97895132
68GATA2_21666600_ChIP-Seq_HMVEC_Human0.97329407
69* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.97099572
70BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.96813708
71STAT3_1855785_ChIP-Seq_MESCs_Mouse0.96384161
72KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.95867439
73* RUNX1_27514584_Chip-Seq_MCF-7_Human0.92785860
74KDM2B_26808549_Chip-Seq_DND41_Human0.91940646
75* CREB1_26743006_Chip-Seq_LNCaP_Human0.91723940
76NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.91690226
77NRF2_20460467_ChIP-Seq_MEFs_Mouse0.91690226
78SA1_27219007_Chip-Seq_ERYTHROID_Human0.90787691
79EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.90317616
80RXRA_24833708_ChIP-Seq_LIVER_Mouse0.89815876
81BCOR_27268052_Chip-Seq_Bcells_Human0.88226225
82IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.88140430
83CTCF_27219007_Chip-Seq_Bcells_Human0.87725705
84AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.87281456
85ESR2_21235772_ChIP-Seq_MCF-7_Human0.86511723
86AUTS2_25519132_ChIP-Seq_293T-REX_Human0.86287732
87PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.80357758
88* GATA4_25053715_ChIP-Seq_YYC3_Human0.79215403
89* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.78174235
90* SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.77222308
91GATA1_19941826_ChIP-Seq_K562_Human0.77075093
92RARG_19884340_ChIP-ChIP_MEFs_Mouse0.74835236
93TAF15_26573619_Chip-Seq_HEK293_Human0.70911953
94PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.70445049
95EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.69929075
96PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.69554231
97* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.69462151
98* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.67583586
99PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.66214228
100ESR1_20079471_ChIP-ChIP_T-47D_Human0.65958890
101FOXO3_23340844_ChIP-Seq_DLD1_Human0.64715767
102FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.64646643
103* FOXA1_25552417_ChIP-Seq_VCAP_Human0.64435253
104CBP_21632823_ChIP-Seq_H3396_Human0.63561216
105PIAS1_25552417_ChIP-Seq_VCAP_Human0.63486528
106CEBPB_22108803_ChIP-Seq_LS180_Human0.63015949
107ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.62154695
108MYC_19915707_ChIP-ChIP_AK7_Human0.61347051
109GATA2_19941826_ChIP-Seq_K562_Human0.61020886
110KAP1_22055183_ChIP-Seq_ESCs_Mouse0.59245532
111BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.59232964
112IRF8_22096565_ChIP-ChIP_GC-B_Human0.59130935
113CDX2_19796622_ChIP-Seq_MESCs_Mouse0.58537427
114GATA1_19941827_ChIP-Seq_MEL_Mouse0.57726222
115NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.57567210
116SALL4_18804426_ChIP-ChIP_XEN_Mouse0.57362570
117STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.56549093
118TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.56544694
119EGR1_19032775_ChIP-ChIP_M12_Human0.56479476
120PPAR_26484153_Chip-Seq_NCI-H1993_Human0.56187489
121RARA_24833708_ChIP-Seq_LIVER_Mouse0.55329802
122* SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.55287671
123BCAT_22108803_ChIP-Seq_LS180_Human0.54561484
124SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.53105925
125ERG_21242973_ChIP-ChIP_JURKAT_Human0.53008400
126ESET_19884257_ChIP-Seq_ESCs_Mouse0.52154537
127SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.51072543
128AR_20517297_ChIP-Seq_VCAP_Human0.50503738
129RARB_24833708_ChIP-Seq_LIVER_Mouse0.49965914
130* PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.49874440
131E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.49744029
132OCT4_20526341_ChIP-Seq_ESCs_Human0.48905690
133* P53_21459846_ChIP-Seq_SAOS-2_Human0.48155872
134LXR_22292898_ChIP-Seq_THP-1_Human0.48118329
135SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.48061630
136STAT1_17558387_ChIP-Seq_HELA_Human0.47933817
137TBX20_22328084_ChIP-Seq_HEART_Mouse0.47783115
138TBX20_22080862_ChIP-Seq_HEART_Mouse0.47783115
139AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.47600137
140SMAD4_21741376_ChIP-Seq_EPCs_Human0.47287589
141GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.47027517
142ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.45462020
143NCOR_22424771_ChIP-Seq_293T_Human0.45415159
144MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.45079991
145TAF2_19829295_ChIP-Seq_ESCs_Human0.44825593
146P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.44423161
147CDX2_22108803_ChIP-Seq_LS180_Human0.44196331
148SOX2_20726797_ChIP-Seq_SW620_Human0.43392490
149NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.42599062
150EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.41772181
151FOXH1_21741376_ChIP-Seq_EPCs_Human0.41444462

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.87261147
2MP0005360_urolithiasis7.05063970
3MP0005365_abnormal_bile_salt5.66089425
4MP0005085_abnormal_gallbladder_physiolo5.60621299
5MP0008875_abnormal_xenobiotic_pharmacok4.70976997
6MP0003806_abnormal_nucleotide_metabolis3.93717842
7MP0010329_abnormal_lipoprotein_level3.50222762
8MP0003252_abnormal_bile_duct3.41790525
9MP0005332_abnormal_amino_acid3.01771446
10MP0003195_calcinosis2.93083201
11MP0009840_abnormal_foam_cell2.91532894
12MP0005083_abnormal_biliary_tract2.83623391
13MP0002118_abnormal_lipid_homeostasis2.40581367
14MP0001666_abnormal_nutrient_absorption2.31911500
15MP0004019_abnormal_vitamin_homeostasis2.22451760
16MP0000751_myopathy2.13381540
17MP0003191_abnormal_cellular_cholesterol2.12281714
18MP0000609_abnormal_liver_physiology2.08472047
19MP0005670_abnormal_white_adipose1.91887765
20MP0005584_abnormal_enzyme/coenzyme_acti1.85191942
21MP0010234_abnormal_vibrissa_follicle1.78308823
22MP0002138_abnormal_hepatobiliary_system1.77181493
23MP0005319_abnormal_enzyme/_coenzyme1.75750713
24MP0001764_abnormal_homeostasis1.59499681
25MP0006138_congestive_heart_failure1.58174479
26MP0003868_abnormal_feces_composition1.56807995
27MP0005409_darkened_coat_color1.56115555
28MP0003186_abnormal_redox_activity1.54805239
29MP0008438_abnormal_cutaneous_collagen1.53690089
30MP0003011_delayed_dark_adaptation1.53502200
31MP0004130_abnormal_muscle_cell1.51883295
32MP0009643_abnormal_urine_homeostasis1.47972532
33MP0005451_abnormal_body_composition1.42142115
34MP0003690_abnormal_glial_cell1.37913118
35MP0003656_abnormal_erythrocyte_physiolo1.36954793
36MP0000604_amyloidosis1.34313405
37MP0003329_amyloid_beta_deposits1.33175559
38MP0004858_abnormal_nervous_system1.31488986
39MP0004272_abnormal_basement_membrane1.30520730
40MP0003300_gastrointestinal_ulcer1.28723927
41MP0002971_abnormal_brown_adipose1.27444641
42MP0005666_abnormal_adipose_tissue1.26822780
43MP0000003_abnormal_adipose_tissue1.25759771
44MP0002876_abnormal_thyroid_physiology1.24040410
45MP0005330_cardiomyopathy1.20395323
46MP0003566_abnormal_cell_adhesion1.19288068
47MP0005535_abnormal_body_temperature1.16928951
48MP0004087_abnormal_muscle_fiber1.16652093
49MP0001661_extended_life_span1.16062719
50MP0006036_abnormal_mitochondrial_physio1.15729528
51MP0005636_abnormal_mineral_homeostasis1.14724002
52MP0009697_abnormal_copulation1.11412575
53MP0005647_abnormal_sex_gland1.10944192
54MP0004043_abnormal_pH_regulation1.09731474
55MP0000747_muscle_weakness1.09120460
56MP0004264_abnormal_extraembryonic_tissu1.08090244
57MP0008260_abnormal_autophagy1.07691327
58MP0004036_abnormal_muscle_relaxation1.07326597
59MP0000749_muscle_degeneration1.07111976
60MP0004782_abnormal_surfactant_physiolog1.06696518
61MP0005334_abnormal_fat_pad1.04330538
62MP0003828_pulmonary_edema1.01522588
63MP0000598_abnormal_liver_morphology0.98616057
64MP0002078_abnormal_glucose_homeostasis0.96773433
65MP0000678_abnormal_parathyroid_gland0.95761390
66MP0002837_dystrophic_cardiac_calcinosis0.95249898
67MP0002254_reproductive_system_inflammat0.93647310
68MP0009763_increased_sensitivity_to0.92422422
69MP0005385_cardiovascular_system_phenoty0.91622055
70MP0001544_abnormal_cardiovascular_syste0.91622055
71MP0009764_decreased_sensitivity_to0.91353466
72MP0000759_abnormal_skeletal_muscle0.89665883
73MP0002269_muscular_atrophy0.88310296
74MP0003879_abnormal_hair_cell0.86108826
75MP0010630_abnormal_cardiac_muscle0.85942904
76MP0009642_abnormal_blood_homeostasis0.85739398
77MP0002972_abnormal_cardiac_muscle0.82418164
78MP0000920_abnormal_myelination0.82281751
79MP0003172_abnormal_lysosome_physiology0.80343775
80MP0004185_abnormal_adipocyte_glucose0.80258185
81MP0001756_abnormal_urination0.80002866
82MP0000013_abnormal_adipose_tissue0.78543113
83MP0004233_abnormal_muscle_weight0.78266975
84MP0000343_altered_response_to0.78039996
85MP0008469_abnormal_protein_level0.77492902
86MP0002106_abnormal_muscle_physiology0.77321450
87MP0003453_abnormal_keratinocyte_physiol0.76664692
88MP0000858_altered_metastatic_potential0.76650189
89MP0009765_abnormal_xenobiotic_induced0.76203096
90MP0004084_abnormal_cardiac_muscle0.75113833
91MP0005448_abnormal_energy_balance0.74864885
92MP0008775_abnormal_heart_ventricle0.73007784
93MP0005376_homeostasis/metabolism_phenot0.72856373
94MP0002896_abnormal_bone_mineralization0.71783473
95MP0005501_abnormal_skin_physiology0.71382225
96MP0010155_abnormal_intestine_physiology0.70404109
97MP0005375_adipose_tissue_phenotype0.70377497
98MP0005164_abnormal_response_to0.70343096
99MP0009780_abnormal_chondrocyte_physiolo0.70268980
100MP0000249_abnormal_blood_vessel0.70135281
101MP0005275_abnormal_skin_tensile0.69931146
102MP0004947_skin_inflammation0.69852315
103MP0003950_abnormal_plasma_membrane0.69672162
104MP0002132_abnormal_respiratory_system0.69398569
105MP0003183_abnormal_peptide_metabolism0.68353703
106MP0004147_increased_porphyrin_level0.68041730
107MP0002822_catalepsy0.66509161
108MP0005058_abnormal_lysosome_morphology0.65404415
109MP0005408_hypopigmentation0.63289237
110MP0005084_abnormal_gallbladder_morpholo0.62983873
111MP0002136_abnormal_kidney_physiology0.61902439
112MP0009115_abnormal_fat_cell0.60651128
113MP0006035_abnormal_mitochondrial_morpho0.59958453
114MP0002970_abnormal_white_adipose0.59207869
115MP0005266_abnormal_metabolism0.59172767
116MP0001765_abnormal_ion_homeostasis0.58000005
117MP0003953_abnormal_hormone_level0.55876689
118MP0003075_altered_response_to0.55523956
119MP0003705_abnormal_hypodermis_morpholog0.55126585
120MP0008872_abnormal_physiological_respon0.54104009
121MP0000639_abnormal_adrenal_gland0.53135386
122MP0008874_decreased_physiological_sensi0.53026956
123MP0005220_abnormal_exocrine_pancreas0.52091050
124MP0000230_abnormal_systemic_arterial0.51601509
125MP0003724_increased_susceptibility_to0.48638935
126MP0002796_impaired_skin_barrier0.47736369
127MP0003959_abnormal_lean_body0.47347783
128MP0003633_abnormal_nervous_system0.45522988
129MP0002168_other_aberrant_phenotype0.44542391
130MP0005452_abnormal_adipose_tissue0.43455955
131MP0002090_abnormal_vision0.42701098
132MP0003638_abnormal_response/metabolism_0.42375059
133MP0001881_abnormal_mammary_gland0.42334412
134MP0010368_abnormal_lymphatic_system0.41260576
135MP0005395_other_phenotype0.38905102
136MP0004885_abnormal_endolymph0.35701312
137MP0003631_nervous_system_phenotype0.35515396
138MP0004381_abnormal_hair_follicle0.33927514
139MP0006082_CNS_inflammation0.33731420
140MP0002069_abnormal_eating/drinking_beha0.33238818
141MP0005464_abnormal_platelet_physiology0.33065142
142MP0008873_increased_physiological_sensi0.32965198
143MP0003632_abnormal_nervous_system0.31244568
144MP0005166_decreased_susceptibility_to0.30937434
145MP0004142_abnormal_muscle_tone0.29939232
146MP0002229_neurodegeneration0.28069492
147MP0002295_abnormal_pulmonary_circulatio0.27902456

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.61033300
2Intrahepatic cholestasis (HP:0001406)6.47406857
3Deep venous thrombosis (HP:0002625)5.95303249
4Xanthomatosis (HP:0000991)5.77638193
5Abnormality of monocarboxylic acid metabolism (HP:0010996)5.37102784
6Prolonged partial thromboplastin time (HP:0003645)5.11134201
7Hyperlipoproteinemia (HP:0010980)5.09768658
8Hypobetalipoproteinemia (HP:0003563)5.01758719
9Hyperglycinuria (HP:0003108)4.79450132
10Abnormality of serine family amino acid metabolism (HP:0010894)4.68051558
11Abnormality of glycine metabolism (HP:0010895)4.68051558
12Hyperammonemia (HP:0001987)4.62263861
13Hyperglycinemia (HP:0002154)4.52983810
14Ketosis (HP:0001946)4.51408425
15Complement deficiency (HP:0004431)4.29423163
16Epidermoid cyst (HP:0200040)4.24285300
17Abnormality of glutamine family amino acid metabolism (HP:0010902)4.21288409
18Hypolipoproteinemia (HP:0010981)3.96740802
19Abnormality of aspartate family amino acid metabolism (HP:0010899)3.87707298
20Hypoglycemic coma (HP:0001325)3.84703677
21Abnormality of fatty-acid metabolism (HP:0004359)3.84411139
22Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.77518012
23Joint hemorrhage (HP:0005261)3.73579169
24Abnormality of sulfur amino acid metabolism (HP:0004339)3.72623161
25Rhabdomyolysis (HP:0003201)3.70247246
26Hypoalphalipoproteinemia (HP:0003233)3.66956717
27Ketoacidosis (HP:0001993)3.65002467
28Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.60765050
29Abnormality of methionine metabolism (HP:0010901)3.60269743
30Exercise-induced myalgia (HP:0003738)3.59369329
31Fat malabsorption (HP:0002630)3.46956523
32Abnormality of the common coagulation pathway (HP:0010990)3.39332413
33Hypercholesterolemia (HP:0003124)3.23498908
34Abnormality of serum amino acid levels (HP:0003112)3.10730190
35Abnormality of dicarboxylic acid metabolism (HP:0010995)3.10005440
36Dicarboxylic aciduria (HP:0003215)3.10005440
37Hyperbilirubinemia (HP:0002904)3.08711803
38Conjugated hyperbilirubinemia (HP:0002908)3.08550141
39Delayed CNS myelination (HP:0002188)3.04601606
40Polycythemia (HP:0001901)2.97670286
41Metabolic acidosis (HP:0001942)2.94661793
42Abnormality of complement system (HP:0005339)2.92960043
43Abnormality of purine metabolism (HP:0004352)2.91076365
44Abnormality of the intrinsic pathway (HP:0010989)2.86833118
45Abnormality of nucleobase metabolism (HP:0010932)2.85260801
46Gout (HP:0001997)2.84820008
47Glomerulonephritis (HP:0000099)2.83397747
48Lethargy (HP:0001254)2.80184140
49Abnormality of pyrimidine metabolism (HP:0004353)2.73629673
50Ileus (HP:0002595)2.67341432
51Cerebral edema (HP:0002181)2.64169132
52Flat acetabular roof (HP:0003180)2.63529753
53Steatorrhea (HP:0002570)2.62852821
54Increased variability in muscle fiber diameter (HP:0003557)2.62115855
55Vascular calcification (HP:0004934)2.58846766
56Increased connective tissue (HP:0009025)2.56883785
57Acanthocytosis (HP:0001927)2.56058635
58Abnormal gallbladder morphology (HP:0012437)2.55314969
59Skin nodule (HP:0200036)2.54004148
60Generalized aminoaciduria (HP:0002909)2.52434623
61Abnormality of skeletal muscle fiber size (HP:0012084)2.51929800
62Centrally nucleated skeletal muscle fibers (HP:0003687)2.50354740
63Myocardial infarction (HP:0001658)2.49961230
64Hepatocellular carcinoma (HP:0001402)2.47495480
65Myopathic facies (HP:0002058)2.47463259
66Cholecystitis (HP:0001082)2.41651409
67Abnormal gallbladder physiology (HP:0012438)2.41651409
68Irritability (HP:0000737)2.41085573
69Protrusio acetabuli (HP:0003179)2.40305458
70Vomiting (HP:0002013)2.39342310
71Abnormality of proline metabolism (HP:0010907)2.37417007
72Hydroxyprolinuria (HP:0003080)2.37417007
73Cholelithiasis (HP:0001081)2.36669920
74Brushfield spots (HP:0001088)2.35634703
75Vertebral compression fractures (HP:0002953)2.33716484
76Alkalosis (HP:0001948)2.33290384
77Muscle fiber inclusion bodies (HP:0100299)2.30291641
78Hypoglycemic seizures (HP:0002173)2.29928029
79Proximal tubulopathy (HP:0000114)2.29922351
80Asymmetric septal hypertrophy (HP:0001670)2.29465222
81Right ventricular cardiomyopathy (HP:0011663)2.29007026
82Acanthosis nigricans (HP:0000956)2.28691578
83Abnormality of carpal bone ossification (HP:0006257)2.28121624
84Cardiovascular calcification (HP:0011915)2.27958121
85Type 1 muscle fiber predominance (HP:0003803)2.27134231
86Nemaline bodies (HP:0003798)2.26566226
87Amyloidosis (HP:0011034)2.25514007
88Nausea (HP:0002018)2.24523229
89Spontaneous abortion (HP:0005268)2.24194633
90Difficulty running (HP:0009046)2.23047532
91Axonal loss (HP:0003447)2.22470601
92Distal lower limb muscle weakness (HP:0009053)2.22122217
93Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.22045257
94Sensorimotor neuropathy (HP:0007141)2.20713295
95Hypochromic microcytic anemia (HP:0004840)2.19031107
96Pancreatitis (HP:0001733)2.16944501
97Hyperuricemia (HP:0002149)2.15883624
98Increased purine levels (HP:0004368)2.15883624
99Spastic diplegia (HP:0001264)2.13304699
100Systemic lupus erythematosus (HP:0002725)2.11928264
101Enlarged kidneys (HP:0000105)2.10275862
102Neonatal onset (HP:0003623)2.08709885
103Abnormality of the gallbladder (HP:0005264)2.06982896
104Muscle stiffness (HP:0003552)2.05631515
105Rickets (HP:0002748)2.03760443
106Nephritis (HP:0000123)2.03756335
107Abnormality of urine glucose concentration (HP:0011016)2.02889569
108Glycosuria (HP:0003076)2.02889569
109Malnutrition (HP:0004395)2.01559706
110Abnormality of glycolysis (HP:0004366)2.01332869
111Increased serum pyruvate (HP:0003542)2.01332869
112Hypertriglyceridemia (HP:0002155)2.01295072
113Neurofibrillary tangles (HP:0002185)2.00765158
114Late onset (HP:0003584)2.00118022
115Hemorrhage of the eye (HP:0011885)1.99997700
116Mitral stenosis (HP:0001718)1.99946391
117Renal cortical cysts (HP:0000803)1.99713741
118Neck muscle weakness (HP:0000467)1.99644221
119Breech presentation (HP:0001623)1.98956206
120Mildly elevated creatine phosphokinase (HP:0008180)1.97746975
121Reticulocytosis (HP:0001923)1.94531862
122Hypophosphatemic rickets (HP:0004912)1.93371274
123Distal lower limb amyotrophy (HP:0008944)1.92260423
124Opisthotonus (HP:0002179)1.89818832
125Hyperinsulinemic hypoglycemia (HP:0000825)1.89738713
126Cerebral aneurysm (HP:0004944)1.89082051
127Purpura (HP:0000979)1.88773764
128Methylmalonic aciduria (HP:0012120)1.88638607
129Abnormal enzyme/coenzyme activity (HP:0012379)1.88367524
130Oligomenorrhea (HP:0000876)1.87266185
131Abnormal cartilage morphology (HP:0002763)1.86700560
132Myoglobinuria (HP:0002913)1.85253090
133Growth hormone excess (HP:0000845)1.85065715
134Back pain (HP:0003418)1.84182336
135Abnormality of vitamin metabolism (HP:0100508)1.83082270
136Acute hepatic failure (HP:0006554)1.82441286
137Abnormal tarsal ossification (HP:0008369)1.81664237
138Abnormality of the Achilles tendon (HP:0005109)1.80562343
139Elevated hepatic transaminases (HP:0002910)1.79306874
140Stridor (HP:0010307)1.76191031
141Thin bony cortex (HP:0002753)1.76083864
142Hyporeflexia of lower limbs (HP:0002600)1.75915506
143Muscle fiber splitting (HP:0003555)1.75335135
144Ventricular tachycardia (HP:0004756)1.75196956
145Abnormal ossification of hand bones (HP:0005921)1.74114172
146Esophageal varix (HP:0002040)1.71214039
147Mucopolysacchariduria (HP:0008155)1.68595303
148Urinary glycosaminoglycan excretion (HP:0003541)1.68595303
149EMG: myopathic abnormalities (HP:0003458)1.67809134
150Cupped ribs (HP:0000887)1.65809513
151Sudden death (HP:0001699)1.65365657
152Dysostosis multiplex (HP:0000943)1.64225815
153Widely patent fontanelles and sutures (HP:0004492)1.64060865

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.11608084
2SIK14.18619255
3FGFR43.26230392
4CAMK1D2.81376845
5STK392.75202109
6INSRR2.51839737
7OXSR12.45757852
8WNK42.42085679
9ERN12.39587044
10EPHB12.25285425
11CAMK1G2.24072239
12EEF2K2.17193410
13PRPF4B2.15735261
14PDK42.05285997
15PDK32.05285997
16EPHA22.02824394
17TTN2.00692583
18TRIB31.93945104
19MST1R1.84768933
20ERBB41.82436527
21FGFR21.81349502
22MAP2K41.70860413
23PINK11.69428962
24RIPK41.60858784
25PDGFRA1.56593816
26PRKAA21.53744218
27TAOK31.50664555
28DAPK21.43827917
29MAP3K61.39564953
30DDR21.35931829
31TESK11.29581683
32EPHB21.26468571
33MAP3K11.22798137
34MAPK111.22239055
35MYLK1.22188778
36MET1.21905644
37PIK3CG1.21033334
38SGK2231.20897684
39SGK4941.20897684
40MAP3K71.19606014
41PDK21.18479041
42PRKG21.16225770
43LATS21.09433607
44WNK31.07746159
45MAPKAPK31.06898883
46JAK21.04917590
47PDPK11.04514883
48ABL21.02018102
49EPHA41.01706252
50PKN10.97155663
51TGFBR20.96629430
52PKN20.95327110
53PBK0.93686617
54TYK20.92506479
55SMG10.92096182
56PAK40.91755851
57PRKAA10.90463194
58FLT30.90106554
59MAP3K30.88978452
60CDC42BPA0.88554144
61ZAP700.87577120
62LMTK20.84477513
63MAP3K130.83661298
64JAK10.82596896
65PHKG10.81937043
66PHKG20.81937043
67PRKACG0.80194866
68PRKCQ0.79172275
69ICK0.78898610
70PTK60.76572795
71FRK0.76372934
72CAMK2G0.76249771
73TAOK20.75833056
74PDK10.73876711
75PRKCZ0.73846758
76CSNK1G10.72167864
77MAPK120.72066703
78NTRK10.71732997
79TIE10.71716566
80MTOR0.71652602
81GSK3A0.71288889
82NEK90.71041694
83GRK60.70410698
84RIPK10.67038545
85FER0.66108046
86MAPK150.66039367
87CDK60.65945460
88ARAF0.65798110
89BMX0.64949085
90CSNK1G20.63118372
91MAP3K110.62898719
92CSNK1G30.62618951
93TBK10.62396028
94PAK30.62254594
95MAPK40.61361579
96SGK30.61107095
97ERBB20.60417245
98TYRO30.59032832
99WNK10.56025741
100IRAK20.55924820
101RET0.55741160
102MARK20.55455339
103DYRK1B0.53882605
104SCYL20.53470578
105CSNK1A1L0.53082132
106TESK20.52486775
107PIM20.52045281
108DMPK0.51161775
109MATK0.50428396
110CSK0.50407651
111ACVR1B0.50310711
112JAK30.49994615
113TRPM70.49754079
114MAP2K60.49226422
115IRAK10.49183412
116NME20.47975583
117KSR20.45868171
118PRKCH0.45148797
119IGF1R0.44867950
120FGFR30.44630754
121MAP3K140.44120278
122MAP2K10.43972543
123PRKD10.43946763
124RAF10.42886059
125TAOK10.41999239
126LRRK20.41610320
127IRAK30.41552934
128MAP3K20.41490256
129KDR0.41279552
130SGK20.41091568
131MAPK70.40349438
132OBSCN0.39114502
133PTK20.38969693
134MAPKAPK50.38718257
135MAP3K40.38021548
136CDK120.35635889
137RPS6KA20.35337137
138SRC0.34796518
139PIK3CA0.34678683
140MAP3K80.34495816
141MAP2K30.34417486
142EPHA30.34191039
143PRKACA0.32429099
144LATS10.30303996
145ITK0.29546108
146PRKCA0.29147512
147IKBKE0.28473451

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.75965604
2Nitrogen metabolism_Homo sapiens_hsa009103.35032070
3Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.07514779
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.02365154
5Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.80025367
6Fatty acid degradation_Homo sapiens_hsa000712.74517240
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.68836591
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.66331197
9* Propanoate metabolism_Homo sapiens_hsa006402.59018789
10Arginine biosynthesis_Homo sapiens_hsa002202.57426872
11Butanoate metabolism_Homo sapiens_hsa006502.56637831
12Tryptophan metabolism_Homo sapiens_hsa003802.49421124
13Fatty acid metabolism_Homo sapiens_hsa012122.45792038
14Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.31512063
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.24961825
16Peroxisome_Homo sapiens_hsa041462.20455540
17PPAR signaling pathway_Homo sapiens_hsa033202.16917829
18Pentose and glucuronate interconversions_Homo sapiens_hsa000402.07673863
19Complement and coagulation cascades_Homo sapiens_hsa046102.02690216
20Fatty acid elongation_Homo sapiens_hsa000621.99599543
21Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.95691436
22Steroid biosynthesis_Homo sapiens_hsa001001.93095025
23beta-Alanine metabolism_Homo sapiens_hsa004101.82138676
24Histidine metabolism_Homo sapiens_hsa003401.78850497
25* Pyruvate metabolism_Homo sapiens_hsa006201.73665753
262-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.71314576
27Chemical carcinogenesis_Homo sapiens_hsa052041.69966554
28Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.69898189
29Steroid hormone biosynthesis_Homo sapiens_hsa001401.66139366
30Other glycan degradation_Homo sapiens_hsa005111.61937236
31Fatty acid biosynthesis_Homo sapiens_hsa000611.58656177
32Caffeine metabolism_Homo sapiens_hsa002321.55260358
33Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.50958418
34Retinol metabolism_Homo sapiens_hsa008301.48112327
35Sulfur metabolism_Homo sapiens_hsa009201.47561508
36Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.43209354
37Bile secretion_Homo sapiens_hsa049761.43118045
38Phenylalanine metabolism_Homo sapiens_hsa003601.38107244
39Drug metabolism - other enzymes_Homo sapiens_hsa009831.35552257
40Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.28897800
41Staphylococcus aureus infection_Homo sapiens_hsa051501.27838252
42Tyrosine metabolism_Homo sapiens_hsa003501.27368275
43* Carbon metabolism_Homo sapiens_hsa012001.26985214
44Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.20210468
45Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.20115306
46Starch and sucrose metabolism_Homo sapiens_hsa005001.19710690
47Selenocompound metabolism_Homo sapiens_hsa004501.17769193
48ABC transporters_Homo sapiens_hsa020101.14590954
49Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.08876399
50Fat digestion and absorption_Homo sapiens_hsa049751.08710261
51Biosynthesis of amino acids_Homo sapiens_hsa012301.06983654
52Cysteine and methionine metabolism_Homo sapiens_hsa002701.05981049
53Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.04784267
54Glycerolipid metabolism_Homo sapiens_hsa005611.03176371
55Cyanoamino acid metabolism_Homo sapiens_hsa004601.00038254
56Folate biosynthesis_Homo sapiens_hsa007900.98052254
57Arginine and proline metabolism_Homo sapiens_hsa003300.95432431
58Vitamin B6 metabolism_Homo sapiens_hsa007500.94655452
59Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.88981555
60Vitamin digestion and absorption_Homo sapiens_hsa049770.85524036
61Glycosaminoglycan degradation_Homo sapiens_hsa005310.80039024
62Sulfur relay system_Homo sapiens_hsa041220.76604490
63Lysine degradation_Homo sapiens_hsa003100.74374350
64Glutathione metabolism_Homo sapiens_hsa004800.73229505
65Maturity onset diabetes of the young_Homo sapiens_hsa049500.69878790
66Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.66074901
67* Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.65890445
68Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.64721689
69Pentose phosphate pathway_Homo sapiens_hsa000300.62854653
70* Metabolic pathways_Homo sapiens_hsa011000.50481562
71alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.47460321
72Adipocytokine signaling pathway_Homo sapiens_hsa049200.45609987
73Glycerophospholipid metabolism_Homo sapiens_hsa005640.35849800
74Central carbon metabolism in cancer_Homo sapiens_hsa052300.33753634
75Pertussis_Homo sapiens_hsa051330.32388171
76Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.31435779
77Linoleic acid metabolism_Homo sapiens_hsa005910.30784143
78Acute myeloid leukemia_Homo sapiens_hsa052210.30157945
79Insulin resistance_Homo sapiens_hsa049310.26938795
80Amoebiasis_Homo sapiens_hsa051460.24617437
81Fructose and mannose metabolism_Homo sapiens_hsa000510.23694334
82ECM-receptor interaction_Homo sapiens_hsa045120.21876746
83AMPK signaling pathway_Homo sapiens_hsa041520.20367401
84Prion diseases_Homo sapiens_hsa050200.18282494
85One carbon pool by folate_Homo sapiens_hsa006700.17733507
86Focal adhesion_Homo sapiens_hsa045100.16954076
87Dilated cardiomyopathy_Homo sapiens_hsa054140.15399333
88Sphingolipid metabolism_Homo sapiens_hsa006000.15261035
89Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.15250246
90Glucagon signaling pathway_Homo sapiens_hsa049220.15188679
91Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.14860875
92GnRH signaling pathway_Homo sapiens_hsa049120.13252829
93HIF-1 signaling pathway_Homo sapiens_hsa040660.12730457
94VEGF signaling pathway_Homo sapiens_hsa043700.12374592
95AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.12088367
96Galactose metabolism_Homo sapiens_hsa000520.11068483
97Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.09622538
98Ether lipid metabolism_Homo sapiens_hsa005650.07195434
99Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.06267002
100Ovarian steroidogenesis_Homo sapiens_hsa049130.03600733
101Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563-0.1979468
102Renin-angiotensin system_Homo sapiens_hsa04614-0.1933640
103Protein digestion and absorption_Homo sapiens_hsa04974-0.1919386
104Hepatitis C_Homo sapiens_hsa05160-0.1906367
105Type II diabetes mellitus_Homo sapiens_hsa04930-0.1875474
106African trypanosomiasis_Homo sapiens_hsa05143-0.1814827
107Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1724402
108Parkinsons disease_Homo sapiens_hsa05012-0.1718196
109Alzheimers disease_Homo sapiens_hsa05010-0.1572499
110Lysosome_Homo sapiens_hsa04142-0.1536184
111Regulation of autophagy_Homo sapiens_hsa04140-0.1294859
112Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1135849
113Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1117872
114Mineral absorption_Homo sapiens_hsa04978-0.1023462
115Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0782492
116Oxidative phosphorylation_Homo sapiens_hsa00190-0.0721655
117Insulin signaling pathway_Homo sapiens_hsa04910-0.0089918

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