ACSS3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1tryptophan catabolic process (GO:0006569)5.42369880
2indole-containing compound catabolic process (GO:0042436)5.42369880
3indolalkylamine catabolic process (GO:0046218)5.42369880
4aromatic amino acid family catabolic process (GO:0009074)5.16753814
5tryptophan metabolic process (GO:0006568)5.13245167
6homocysteine metabolic process (GO:0050667)4.95241704
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.87300866
8L-phenylalanine catabolic process (GO:0006559)4.87300866
9triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.64797715
10high-density lipoprotein particle remodeling (GO:0034375)4.53150652
11regulation of apoptotic cell clearance (GO:2000425)4.52588866
12erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.51144657
13L-phenylalanine metabolic process (GO:0006558)4.51144657
14kynurenine metabolic process (GO:0070189)4.45984775
15intestinal cholesterol absorption (GO:0030299)4.42931215
16urea metabolic process (GO:0019627)4.29129124
17urea cycle (GO:0000050)4.29129124
18protein-lipid complex assembly (GO:0065005)4.27961671
19cellular biogenic amine catabolic process (GO:0042402)4.27505592
20amine catabolic process (GO:0009310)4.27505592
21embryonic retina morphogenesis in camera-type eye (GO:0060059)4.26646032
22regulation of plasminogen activation (GO:0010755)4.09010969
23indolalkylamine metabolic process (GO:0006586)4.01349720
24reverse cholesterol transport (GO:0043691)4.01054225
25regulation of triglyceride catabolic process (GO:0010896)3.98236605
26bile acid biosynthetic process (GO:0006699)3.97103245
27NAD biosynthetic process (GO:0009435)3.93955252
28acylglycerol homeostasis (GO:0055090)3.92789382
29triglyceride homeostasis (GO:0070328)3.92789382
30ethanol oxidation (GO:0006069)3.92663144
31complement activation, alternative pathway (GO:0006957)3.90410150
32phospholipid efflux (GO:0033700)3.89554327
33plasma lipoprotein particle remodeling (GO:0034369)3.86957475
34protein-lipid complex remodeling (GO:0034368)3.86957475
35macromolecular complex remodeling (GO:0034367)3.86957475
36nitrogen cycle metabolic process (GO:0071941)3.84536660
37fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.83191180
38superoxide anion generation (GO:0042554)3.80224228
39negative regulation of lipase activity (GO:0060192)3.79908837
40protein-lipid complex subunit organization (GO:0071825)3.79097628
41protein carboxylation (GO:0018214)3.78722555
42peptidyl-glutamic acid carboxylation (GO:0017187)3.78722555
43amino-acid betaine metabolic process (GO:0006577)3.77634251
44biotin metabolic process (GO:0006768)3.75812802
45bile acid metabolic process (GO:0008206)3.71414701
46aromatic amino acid family metabolic process (GO:0009072)3.71328410
47fibrinolysis (GO:0042730)3.62929960
48regulation of protein activation cascade (GO:2000257)3.62496648
49regulation of cholesterol esterification (GO:0010872)3.60501461
50tyrosine metabolic process (GO:0006570)3.58133415
51cellular glucuronidation (GO:0052695)3.53543577
52alpha-linolenic acid metabolic process (GO:0036109)3.51958531
53linoleic acid metabolic process (GO:0043651)3.51207927
54pyridine nucleotide biosynthetic process (GO:0019363)3.50166652
55nicotinamide nucleotide biosynthetic process (GO:0019359)3.50166652
56plasma lipoprotein particle clearance (GO:0034381)3.49921198
57low-density lipoprotein particle remodeling (GO:0034374)3.49902382
58low-density lipoprotein particle clearance (GO:0034383)3.44936601
59bile acid and bile salt transport (GO:0015721)3.43901353
60imidazole-containing compound metabolic process (GO:0052803)3.40179098
61phospholipid homeostasis (GO:0055091)3.39250718
62regulation of fibrinolysis (GO:0051917)3.38862369
63sulfur amino acid catabolic process (GO:0000098)3.37807914
64regulation of complement activation (GO:0030449)3.35917664
65glyoxylate metabolic process (GO:0046487)3.34211655
66regulation of sequestering of triglyceride (GO:0010889)3.34107623
67negative regulation of complement activation (GO:0045916)3.34036813
68serine family amino acid catabolic process (GO:0009071)3.33973527
69alpha-amino acid catabolic process (GO:1901606)3.32105707
70cholesterol efflux (GO:0033344)3.30246455
71regulation of cholesterol biosynthetic process (GO:0045540)3.29086084
72coenzyme catabolic process (GO:0009109)3.25534900
73positive regulation of lipid catabolic process (GO:0050996)3.24108416
74regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.22380681
75ethanol metabolic process (GO:0006067)3.21929147
76valine metabolic process (GO:0006573)3.21591822
77negative regulation of fibrinolysis (GO:0051918)3.18462921
78neutral lipid catabolic process (GO:0046461)3.16925262
79acylglycerol catabolic process (GO:0046464)3.16925262
80negative regulation of blood coagulation (GO:0030195)3.16861790
81negative regulation of hemostasis (GO:1900047)3.16861790
82very-low-density lipoprotein particle assembly (GO:0034379)3.13874944
83glucuronate metabolic process (GO:0019585)3.12511472
84uronic acid metabolic process (GO:0006063)3.12511472
85benzene-containing compound metabolic process (GO:0042537)3.12350938
86opsonization (GO:0008228)3.10434487
87carnitine metabolic process (GO:0009437)3.09578421
88glutamate metabolic process (GO:0006536)3.09188606
89epoxygenase P450 pathway (GO:0019373)3.09149387
90negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.05642444
91cysteine metabolic process (GO:0006534)3.03737847
92branched-chain amino acid catabolic process (GO:0009083)3.03114907
93plasma lipoprotein particle organization (GO:0071827)3.02973605
94regulation of bile acid biosynthetic process (GO:0070857)3.02704278
95exogenous drug catabolic process (GO:0042738)3.02621571
96positive regulation of hemostasis (GO:1900048)3.00395699
97positive regulation of blood coagulation (GO:0030194)3.00395699
98regulation of humoral immune response (GO:0002920)3.00296649
99cellular amino acid catabolic process (GO:0009063)2.97613609
100blood coagulation, intrinsic pathway (GO:0007597)2.96417969
101drug catabolic process (GO:0042737)2.96021857
102positive regulation of cellular amide metabolic process (GO:0034250)2.95883518
103fatty acid beta-oxidation (GO:0006635)2.95749481
104regulation of non-canonical Wnt signaling pathway (GO:2000050)2.95353087
105positive regulation of fatty acid beta-oxidation (GO:0032000)2.95257428
106response to mercury ion (GO:0046689)2.94179075
107complement activation, classical pathway (GO:0006958)2.93532531
108positive regulation of triglyceride lipase activity (GO:0061365)2.92340835
109positive regulation of lipoprotein lipase activity (GO:0051006)2.92340835
110cholesterol homeostasis (GO:0042632)2.92201915
111negative regulation of coagulation (GO:0050819)2.91954809
112fatty acid oxidation (GO:0019395)2.90818809
113triglyceride catabolic process (GO:0019433)2.90147304
114intestinal absorption (GO:0050892)2.88448705
115sterol homeostasis (GO:0055092)2.88377305
116arginine metabolic process (GO:0006525)2.88058654
117lipid oxidation (GO:0034440)2.87514959
118lipoprotein metabolic process (GO:0042157)2.86787708
119acute-phase response (GO:0006953)2.86726274
120carboxylic acid catabolic process (GO:0046395)2.86711952
121organic acid catabolic process (GO:0016054)2.86711952
122diacylglycerol metabolic process (GO:0046339)2.86376886
123protein activation cascade (GO:0072376)2.86214092
124negative regulation of wound healing (GO:0061045)2.85057190
125sterol transport (GO:0015918)2.84369048
126cholesterol transport (GO:0030301)2.84369048
127negative regulation of protein activation cascade (GO:2000258)2.84326058
128dicarboxylic acid biosynthetic process (GO:0043650)2.83484659
129monocarboxylic acid catabolic process (GO:0072329)2.83044448
130short-chain fatty acid metabolic process (GO:0046459)2.83012859
131androgen biosynthetic process (GO:0006702)2.81761833
132negative regulation of cholesterol transport (GO:0032375)2.81134440
133negative regulation of sterol transport (GO:0032372)2.81134440
134indole-containing compound metabolic process (GO:0042430)2.80713145
135plasma lipoprotein particle assembly (GO:0034377)2.79286005
136fatty acid catabolic process (GO:0009062)2.78364315
137branched-chain amino acid metabolic process (GO:0009081)2.77615068
138positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.76160334
139positive regulation of coagulation (GO:0050820)2.75751553
140regulation of cholesterol homeostasis (GO:2000188)2.72572891
141glycine metabolic process (GO:0006544)2.71390619
142negative regulation of sodium ion transport (GO:0010766)2.67939524
143complement activation (GO:0006956)2.63535286
144omega-hydroxylase P450 pathway (GO:0097267)2.62394904
145positive regulation of extracellular matrix organization (GO:1903055)2.61907143
146regulation of cholesterol metabolic process (GO:0090181)2.61170375
147fatty acid homeostasis (GO:0055089)2.60865684
148neurotransmitter-gated ion channel clustering (GO:0072578)2.59449767
149G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.59379535
150lipid homeostasis (GO:0055088)2.58433699

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EGR1_23403033_ChIP-Seq_LIVER_Mouse4.47131423
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.44768901
3RXR_22158963_ChIP-Seq_LIVER_Mouse3.48274587
4GBX2_23144817_ChIP-Seq_PC3_Human3.35973806
5ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.29333988
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.00262257
7* LXR_22158963_ChIP-Seq_LIVER_Mouse2.87172370
8FOXA2_19822575_ChIP-Seq_HepG2_Human2.71093051
9* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.65502459
10RBPJ_22232070_ChIP-Seq_NCS_Mouse2.55489454
11ZFP57_27257070_Chip-Seq_ESCs_Mouse2.45240501
12PCGF2_27294783_Chip-Seq_ESCs_Mouse2.45167482
13FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.41358265
14SUZ12_27294783_Chip-Seq_NPCs_Mouse2.34837197
15NFE2_27457419_Chip-Seq_LIVER_Mouse2.26310317
16FLI1_27457419_Chip-Seq_LIVER_Mouse2.25812685
17NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.24934665
18CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.22050648
19PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.16418445
20PCGF2_27294783_Chip-Seq_NPCs_Mouse2.13159929
21* CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.10561470
22EZH2_27294783_Chip-Seq_NPCs_Mouse2.01461427
23GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.98337505
24CLOCK_20551151_ChIP-Seq_293T_Human1.94530092
25* HNF4A_19822575_ChIP-Seq_HepG2_Human1.87222887
26IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.80299668
27EP300_21415370_ChIP-Seq_HL-1_Mouse1.76277389
28POU3F2_20337985_ChIP-ChIP_501MEL_Human1.73025925
29P53_22387025_ChIP-Seq_ESCs_Mouse1.72783814
30EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.72638797
31HTT_18923047_ChIP-ChIP_STHdh_Human1.69637044
32CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.69119110
33SUZ12_18555785_Chip-Seq_ESCs_Mouse1.68185185
34ESR1_20079471_ChIP-ChIP_T-47D_Human1.67078342
35STAT3_18555785_Chip-Seq_ESCs_Mouse1.64483775
36* PIAS1_25552417_ChIP-Seq_VCAP_Human1.64062373
37E2F1_18555785_Chip-Seq_ESCs_Mouse1.62409489
38SALL4_18804426_ChIP-ChIP_XEN_Mouse1.62404318
39NANOG_18555785_Chip-Seq_ESCs_Mouse1.60852570
40EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.60511318
41ESR1_15608294_ChIP-ChIP_MCF-7_Human1.60339101
42SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.60197973
43GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.59205075
44RUNX1_27457419_Chip-Seq_LIVER_Mouse1.58437940
45TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.58335226
46TRIM28_21343339_ChIP-Seq_HEK293_Human1.57886757
47NMYC_18555785_Chip-Seq_ESCs_Mouse1.56981440
48ZNF217_24962896_ChIP-Seq_MCF-7_Human1.55313661
49OCT4_18555785_Chip-Seq_ESCs_Mouse1.54738523
50CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.51402251
51HIF1A_21447827_ChIP-Seq_MCF-7_Human1.51309249
52Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.51201259
53PU1_27457419_Chip-Seq_LIVER_Mouse1.50647262
54P300_18555785_Chip-Seq_ESCs_Mouse1.50611046
55AR_21572438_ChIP-Seq_LNCaP_Human1.50108468
56* P300_19829295_ChIP-Seq_ESCs_Human1.48670415
57TCF4_18268006_ChIP-ChIP_LS174T_Human1.48661196
58OCT4_21477851_ChIP-Seq_ESCs_Mouse1.48599462
59CMYC_18555785_Chip-Seq_ESCs_Mouse1.48561056
60HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.47714141
61STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.46211290
62* CRX_20693478_ChIP-Seq_RETINA_Mouse1.45988380
63TAF15_26573619_Chip-Seq_HEK293_Human1.45780864
64SOX2_18555785_Chip-Seq_ESCs_Mouse1.43151017
65ESRRB_18555785_Chip-Seq_ESCs_Mouse1.43147478
66SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.42658849
67TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.41012250
68SMAD1_18555785_Chip-Seq_ESCs_Mouse1.39542676
69ZFX_18555785_Chip-Seq_ESCs_Mouse1.39261958
70IGF1R_20145208_ChIP-Seq_DFB_Human1.38640802
71CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.35992703
72PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.34580700
73* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.34418944
74NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.34395109
75BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.34230006
76CDX2_19796622_ChIP-Seq_MESCs_Mouse1.34126990
77KAP1_22055183_ChIP-Seq_ESCs_Mouse1.34106566
78KLF4_18555785_Chip-Seq_ESCs_Mouse1.33322184
79CTCF_18555785_Chip-Seq_ESCs_Mouse1.32618953
80AR_21909140_ChIP-Seq_LNCAP_Human1.31975494
81TAL1_26923725_Chip-Seq_HPCs_Mouse1.30056254
82SMAD4_21799915_ChIP-Seq_A2780_Human1.29980841
83CBX2_27304074_Chip-Seq_ESCs_Mouse1.29689521
84ESR1_21235772_ChIP-Seq_MCF-7_Human1.28681429
85IRF8_22096565_ChIP-ChIP_GC-B_Human1.28524050
86SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.28468346
87MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.28344396
88TP53_16413492_ChIP-PET_HCT116_Human1.26358536
89BMI1_23680149_ChIP-Seq_NPCS_Mouse1.25501222
90ESR2_21235772_ChIP-Seq_MCF-7_Human1.25280078
91* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24864903
92BP1_19119308_ChIP-ChIP_Hs578T_Human1.24465020
93SALL1_21062744_ChIP-ChIP_HESCs_Human1.24413835
94TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24379285
95CTNNB1_20460455_ChIP-Seq_HCT116_Human1.22112001
96ISL1_27105846_Chip-Seq_CPCs_Mouse1.21915011
97* SMAD3_21741376_ChIP-Seq_HESCs_Human1.21337557
98TBX3_20139965_ChIP-Seq_ESCs_Mouse1.20457613
99* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.20435420
100KDM2B_26808549_Chip-Seq_REH_Human1.19915581
101TBX3_20139965_ChIP-Seq_MESCs_Mouse1.19903811
102IRF1_19129219_ChIP-ChIP_H3396_Human1.19576046
103EED_16625203_ChIP-ChIP_MESCs_Mouse1.19093942
104TP53_18474530_ChIP-ChIP_U2OS_Human1.19029282
105ER_23166858_ChIP-Seq_MCF-7_Human1.18070981
106STAT1_17558387_ChIP-Seq_HELA_Human1.17430383
107STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.16106445
108SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.14251141
109SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.11741417
110POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.11289111
111SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.10709421
112* SMAD4_21741376_ChIP-Seq_HESCs_Human1.08361475
113STAT3_23295773_ChIP-Seq_U87_Human1.07960142
114NFIB_24661679_ChIP-Seq_LUNG_Mouse1.06265347
115SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.04991854
116TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04850598
117* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.04622668
118SMAD_19615063_ChIP-ChIP_OVARY_Human1.04379634
119EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.03400852
120GATA1_22025678_ChIP-Seq_K562_Human1.03269546
121STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.03146283
122* AR_25329375_ChIP-Seq_VCAP_Human1.02067537
123NRF2_20460467_ChIP-Seq_MEFs_Mouse0.99690917
124NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.99690917
125PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.98340374
126FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.98111389
127TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98026908
128POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.98026908
129SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.97565109
130TCF4_23295773_ChIP-Seq_U87_Human0.96562321
131BCAT_22108803_ChIP-Seq_LS180_Human0.95618129
132KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.95233574
133KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.95233574
134KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.95233574
135SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.95182761
136FOXM1_26456572_ChIP-Seq_MCF-7_Human0.95138895
137WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.94677464
138ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.94669052
139RNF2_18974828_ChIP-Seq_MESCs_Mouse0.93648016
140EZH2_18974828_ChIP-Seq_MESCs_Mouse0.93648016
141SMAD3_21741376_ChIP-Seq_EPCs_Human0.93619411
142YAP1_20516196_ChIP-Seq_MESCs_Mouse0.93276451
143AHR_22903824_ChIP-Seq_MCF-7_Human0.93067079
144* CTBP1_25329375_ChIP-Seq_LNCAP_Human0.92925556
145PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.92410596
146ARNT_22903824_ChIP-Seq_MCF-7_Human0.92120515
147RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.92076584
148POU5F1_16518401_ChIP-PET_MESCs_Mouse0.91646681
149* RUNX2_22187159_ChIP-Seq_PCA_Human0.91406384
150* CTBP2_25329375_ChIP-Seq_LNCAP_Human0.91353191
151* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.91103648
152CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91071489
153CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.90022321
154TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.89729568
155FOXO3_23340844_ChIP-Seq_DLD1_Human0.89556078
156FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.88922399
157TCF3_18692474_ChIP-Seq_MESCs_Mouse0.88499473
158KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.87660966
159* GATA4_25053715_ChIP-Seq_YYC3_Human0.87451889
160WT1_19549856_ChIP-ChIP_CCG9911_Human0.87198674
161CDX2_20551321_ChIP-Seq_CACO-2_Human0.86784838
162TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.86244099
163NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.85466049

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.52701392
2MP0005360_urolithiasis5.75192727
3MP0005085_abnormal_gallbladder_physiolo5.16037321
4MP0005365_abnormal_bile_salt5.15957686
5MP0003122_maternal_imprinting3.77673140
6MP0008875_abnormal_xenobiotic_pharmacok3.49713371
7MP0003252_abnormal_bile_duct3.28544489
8MP0002876_abnormal_thyroid_physiology3.23728321
9MP0009697_abnormal_copulation3.12854976
10MP0010329_abnormal_lipoprotein_level3.08306639
11MP0005670_abnormal_white_adipose2.93344213
12MP0003195_calcinosis2.80494506
13MP0004019_abnormal_vitamin_homeostasis2.74941089
14MP0000566_synostosis2.47870813
15MP0004272_abnormal_basement_membrane2.30381565
16MP0003806_abnormal_nucleotide_metabolis2.30364461
17MP0010368_abnormal_lymphatic_system2.27644461
18MP0005451_abnormal_body_composition2.16436416
19MP0003011_delayed_dark_adaptation2.15017120
20MP0003890_abnormal_embryonic-extraembry2.11458675
21MP0003123_paternal_imprinting2.03433885
22MP0009764_decreased_sensitivity_to1.98249015
23MP0005332_abnormal_amino_acid1.93850242
24MP0001764_abnormal_homeostasis1.90519265
25MP0003191_abnormal_cellular_cholesterol1.89322374
26MP0002138_abnormal_hepatobiliary_system1.89275818
27MP0005647_abnormal_sex_gland1.81358239
28MP0002118_abnormal_lipid_homeostasis1.75376885
29MP0005083_abnormal_biliary_tract1.68606342
30MP0001666_abnormal_nutrient_absorption1.68413587
31MP0003868_abnormal_feces_composition1.65431667
32MP0004782_abnormal_surfactant_physiolog1.61436627
33MP0003878_abnormal_ear_physiology1.60972816
34MP0005377_hearing/vestibular/ear_phenot1.60972816
35MP0005408_hypopigmentation1.59079724
36MP0003724_increased_susceptibility_to1.57223659
37MP0005646_abnormal_pituitary_gland1.56089329
38MP0009780_abnormal_chondrocyte_physiolo1.55831499
39MP0001188_hyperpigmentation1.52481805
40MP0000609_abnormal_liver_physiology1.48617639
41MP0003186_abnormal_redox_activity1.45061000
42MP0003121_genomic_imprinting1.44117025
43MP0002132_abnormal_respiratory_system1.44082921
44MP0005645_abnormal_hypothalamus_physiol1.43315697
45MP0002089_abnormal_postnatal_growth/wei1.42348062
46MP0010030_abnormal_orbit_morphology1.42003528
47MP0009384_cardiac_valve_regurgitation1.40262575
48MP0002938_white_spotting1.40031341
49MP0006054_spinal_hemorrhage1.35202350
50MP0001915_intracranial_hemorrhage1.34113058
51MP0005257_abnormal_intraocular_pressure1.29765700
52MP0003942_abnormal_urinary_system1.27264962
53MP0003567_abnormal_fetal_cardiomyocyte1.26029656
54MP0005319_abnormal_enzyme/_coenzyme1.22779003
55MP0002697_abnormal_eye_size1.19362660
56MP0002909_abnormal_adrenal_gland1.15397634
57MP0002254_reproductive_system_inflammat1.14848082
58MP0001293_anophthalmia1.14809659
59MP0003937_abnormal_limbs/digits/tail_de1.14438425
60MP0005334_abnormal_fat_pad1.13636945
61MP0006292_abnormal_olfactory_placode1.12590615
62MP0002971_abnormal_brown_adipose1.09349155
63MP0005584_abnormal_enzyme/coenzyme_acti1.09253766
64MP0002233_abnormal_nose_morphology1.08144203
65MP0001984_abnormal_olfaction1.05552919
66MP0005248_abnormal_Harderian_gland1.03842343
67MP0005535_abnormal_body_temperature1.03780011
68MP0009840_abnormal_foam_cell1.03635329
69MP0004130_abnormal_muscle_cell1.02955732
70MP0005171_absent_coat_pigmentation1.02097979
71MP0009672_abnormal_birth_weight0.98608951
72MP0009785_altered_susceptibility_to0.97866636
73MP0002102_abnormal_ear_morphology0.96278524
74MP0001299_abnormal_eye_distance/0.95921375
75MP0009763_increased_sensitivity_to0.95880908
76MP0004381_abnormal_hair_follicle0.95426789
77MP0001835_abnormal_antigen_presentation0.93605312
78MP0000639_abnormal_adrenal_gland0.93097123
79MP0003119_abnormal_digestive_system0.92047070
80MP0003941_abnormal_skin_development0.91756652
81MP0003115_abnormal_respiratory_system0.91467716
82MP0008469_abnormal_protein_level0.89912368
83MP0000751_myopathy0.89675389
84MP0005379_endocrine/exocrine_gland_phen0.88966861
85MP0000534_abnormal_ureter_morphology0.88907516
86MP0008260_abnormal_autophagy0.88689824
87MP0005084_abnormal_gallbladder_morpholo0.87521005
88MP0004133_heterotaxia0.87035832
89MP0005666_abnormal_adipose_tissue0.86700075
90MP0009115_abnormal_fat_cell0.86579767
91MP0002928_abnormal_bile_duct0.86235344
92MP0006138_congestive_heart_failure0.85625929
93MP0008004_abnormal_stomach_pH0.85412394
94MP0001346_abnormal_lacrimal_gland0.84924272
95MP0000579_abnormal_nail_morphology0.83596381
96MP0003632_abnormal_nervous_system0.82850832
97MP0009643_abnormal_urine_homeostasis0.81980023
98MP0003385_abnormal_body_wall0.81872896
99MP0003690_abnormal_glial_cell0.80477284
100MP0002277_abnormal_respiratory_mucosa0.79413560
101MP0002108_abnormal_muscle_morphology0.78840677
102MP0001286_abnormal_eye_development0.78832170
103MP0005167_abnormal_blood-brain_barrier0.78378352
104MP0010630_abnormal_cardiac_muscle0.76747026
105MP0003950_abnormal_plasma_membrane0.76013970
106MP0002092_abnormal_eye_morphology0.75872332
107MP0002419_abnormal_innate_immunity0.75421411
108MP0001986_abnormal_taste_sensitivity0.73675805
109MP0005503_abnormal_tendon_morphology0.70696168
110MP0000681_abnormal_thyroid_gland0.70532232
111MP0009642_abnormal_blood_homeostasis0.69832549
112MP0000427_abnormal_hair_cycle0.69098489
113MP0004215_abnormal_myocardial_fiber0.68420901
114MP0008438_abnormal_cutaneous_collagen0.68372734
115MP0005187_abnormal_penis_morphology0.68038810
116MP0001502_abnormal_circadian_rhythm0.67957798
117MP0002128_abnormal_blood_circulation0.66998726
118MP0005375_adipose_tissue_phenotype0.65915673
119MP0002282_abnormal_trachea_morphology0.65791834
120MP0005330_cardiomyopathy0.65210675
121MP0003136_yellow_coat_color0.64990775
122MP0005448_abnormal_energy_balance0.64976493
123MP0003329_amyloid_beta_deposits0.64682105
124MP0002168_other_aberrant_phenotype0.64425379
125MP0004084_abnormal_cardiac_muscle0.64076887
126MP0005075_abnormal_melanosome_morpholog0.63909064
127MP0009765_abnormal_xenobiotic_induced0.63609539
128MP0002148_abnormal_hypersensitivity_rea0.63017308
129MP0001324_abnormal_eye_pigmentation0.62804220
130MP0002078_abnormal_glucose_homeostasis0.62268974
131MP0001661_extended_life_span0.62252299
132MP0001177_atelectasis0.61920951
133MP0005551_abnormal_eye_electrophysiolog0.61869656
134MP0001119_abnormal_female_reproductive0.61790171
135MP0005636_abnormal_mineral_homeostasis0.61782633
136MP0002060_abnormal_skin_morphology0.61078583
137MP0009053_abnormal_anal_canal0.59245151
138MP0002295_abnormal_pulmonary_circulatio0.59080104
139MP0000569_abnormal_digit_pigmentation0.58931772
140MP0000598_abnormal_liver_morphology0.58338858
141MP0010386_abnormal_urinary_bladder0.58154246
142MP0005395_other_phenotype0.58028667
143MP0008775_abnormal_heart_ventricle0.57116363
144MP0003566_abnormal_cell_adhesion0.56909616
145MP0000428_abnormal_craniofacial_morphol0.56806186
146MP0005464_abnormal_platelet_physiology0.56362283
147MP0004087_abnormal_muscle_fiber0.56329508
148MP0002896_abnormal_bone_mineralization0.55465919
149MP0002269_muscular_atrophy0.55283320
150MP0001529_abnormal_vocalization0.55051986
151MP0005025_abnormal_response_to0.54790653
152MP0002249_abnormal_larynx_morphology0.53850437
153MP0000538_abnormal_urinary_bladder0.53834569
154MP0003436_decreased_susceptibility_to0.53781222
155MP0009703_decreased_birth_body0.53689308
156MP0002136_abnormal_kidney_physiology0.53676367
157MP0004147_increased_porphyrin_level0.53607162
158MP0000762_abnormal_tongue_morphology0.53291491
159MP0004185_abnormal_adipocyte_glucose0.53146157
160MP0003953_abnormal_hormone_level0.53057775
161MP0006082_CNS_inflammation0.52557388
162MP0006276_abnormal_autonomic_nervous0.51587267
163MP0005220_abnormal_exocrine_pancreas0.50757589
164MP0005376_homeostasis/metabolism_phenot0.47161636

Predicted human phenotypes

RankGene SetZ-score
1Prolonged partial thromboplastin time (HP:0003645)5.48984627
2Intrahepatic cholestasis (HP:0001406)5.07002452
3Joint hemorrhage (HP:0005261)4.94535328
4Deep venous thrombosis (HP:0002625)4.28854517
5Abnormality of aromatic amino acid family metabolism (HP:0004338)4.20258308
6Abnormality of monocarboxylic acid metabolism (HP:0010996)3.95721022
7Epidermoid cyst (HP:0200040)3.94345870
8Renal cortical cysts (HP:0000803)3.85465499
9Conjugated hyperbilirubinemia (HP:0002908)3.85321443
10Hyperlipoproteinemia (HP:0010980)3.79519158
11Xanthomatosis (HP:0000991)3.62220227
12Hypobetalipoproteinemia (HP:0003563)3.60000500
13Hyperglycinuria (HP:0003108)3.55685583
14Chromosomal breakage induced by crosslinking agents (HP:0003221)3.50241622
15Abnormality of pyrimidine metabolism (HP:0004353)3.46612673
16Abnormality of methionine metabolism (HP:0010901)3.38787677
17Abnormality of glutamine family amino acid metabolism (HP:0010902)3.36679634
18Complement deficiency (HP:0004431)3.33932385
19Hypoalphalipoproteinemia (HP:0003233)3.28422426
20Abnormality of aspartate family amino acid metabolism (HP:0010899)3.25032076
21Hyperammonemia (HP:0001987)3.23730544
22Hypolipoproteinemia (HP:0010981)3.17542109
23Hyperglycinemia (HP:0002154)3.14295790
24Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.07949020
25Chromsome breakage (HP:0040012)3.06614751
26Abnormality of glycine metabolism (HP:0010895)3.06561258
27Abnormality of serine family amino acid metabolism (HP:0010894)3.06561258
28Vascular calcification (HP:0004934)3.02321561
29Fat malabsorption (HP:0002630)2.99009838
30Abnormality of the common coagulation pathway (HP:0010990)2.98374960
31Chronic hepatic failure (HP:0100626)2.92600182
32Prostate neoplasm (HP:0100787)2.91727591
33Hepatoblastoma (HP:0002884)2.88003456
34Small epiphyses (HP:0010585)2.87831279
35Abnormality of carpal bone ossification (HP:0006257)2.80375151
36Abnormal tarsal ossification (HP:0008369)2.79991029
37Fair hair (HP:0002286)2.77576427
38Cardiovascular calcification (HP:0011915)2.74353650
39Abnormality of sulfur amino acid metabolism (HP:0004339)2.73398393
40Abnormality of the intrinsic pathway (HP:0010989)2.73385036
41Hyperventilation (HP:0002883)2.73157069
42Nephritis (HP:0000123)2.69152287
43Abnormality of the prostate (HP:0008775)2.68876393
44Gingival bleeding (HP:0000225)2.66724709
45Hypophosphatemic rickets (HP:0004912)2.64874551
46Acanthocytosis (HP:0001927)2.64552668
47Alveolar cell carcinoma (HP:0006519)2.64301684
48Hypercholesterolemia (HP:0003124)2.60526017
49Enlarged kidneys (HP:0000105)2.57596379
50Hypoglycemic coma (HP:0001325)2.57006427
51Abnormality of fatty-acid metabolism (HP:0004359)2.56713321
52Reduced antithrombin III activity (HP:0001976)2.55095920
53Bile duct proliferation (HP:0001408)2.50716895
54Abnormal biliary tract physiology (HP:0012439)2.50716895
55Hemorrhage of the eye (HP:0011885)2.49546728
56Ketosis (HP:0001946)2.48700873
57Myocardial infarction (HP:0001658)2.48597527
58Abnormality of serum amino acid levels (HP:0003112)2.45871611
59Abnormality of nucleobase metabolism (HP:0010932)2.45296401
60Osteomalacia (HP:0002749)2.45150381
61Menorrhagia (HP:0000132)2.43082338
62Abnormality of the renal cortex (HP:0011035)2.38925869
63Systemic lupus erythematosus (HP:0002725)2.37296725
64Hypoglycemic seizures (HP:0002173)2.35531983
65Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.35013735
66Steatorrhea (HP:0002570)2.33932590
67Recurrent gram-negative bacterial infections (HP:0005420)2.33374092
68Arthropathy (HP:0003040)2.33284717
69Increased serum pyruvate (HP:0003542)2.30680997
70Choanal stenosis (HP:0000452)2.30369645
71Pancreatitis (HP:0001733)2.29897605
72Neonatal hypoglycemia (HP:0001998)2.29104632
73Hepatocellular carcinoma (HP:0001402)2.28654072
74Abnormality of complement system (HP:0005339)2.25978518
75Hyperbilirubinemia (HP:0002904)2.25672548
76Thyroid-stimulating hormone excess (HP:0002925)2.25264458
77Febrile seizures (HP:0002373)2.25059860
78Hypochromic microcytic anemia (HP:0004840)2.24444390
79Vaginal fistula (HP:0004320)2.23598185
80Abnormality of glycolysis (HP:0004366)2.23082831
81Protrusio acetabuli (HP:0003179)2.20841082
82Abnormal hand bone ossification (HP:0010660)2.20439796
83Broad alveolar ridges (HP:0000187)2.20370832
84Neoplasm of the tracheobronchial system (HP:0100552)2.20037863
85Metabolic acidosis (HP:0001942)2.16837321
86Skin nodule (HP:0200036)2.16779848
87Tubulointerstitial nephritis (HP:0001970)2.16334500
88Abnormality of proline metabolism (HP:0010907)2.15947577
89Hydroxyprolinuria (HP:0003080)2.15947577
90Azoospermia (HP:0000027)2.12256943
91Abnormal ossification of hand bones (HP:0005921)2.08457844
92Pancreatic islet-cell hyperplasia (HP:0004510)2.07643175
93Alacrima (HP:0000522)2.05608612
94Potter facies (HP:0002009)2.05321356
95Facial shape deformation (HP:0011334)2.05321356
96Neonatal short-limb short stature (HP:0008921)2.04612462
97Bronchomalacia (HP:0002780)2.04351786
98Generalized hypopigmentation of hair (HP:0011358)2.04033232
99Spontaneous abortion (HP:0005268)2.01508654
100Mesomelia (HP:0003027)2.01001026
101Broad palm (HP:0001169)2.00830777
102Dicarboxylic aciduria (HP:0003215)2.00715359
103Abnormality of dicarboxylic acid metabolism (HP:0010995)2.00715359
104Myelomeningocele (HP:0002475)2.00125043
105Abnormality of the pubic bones (HP:0003172)1.99672737
106Sensorimotor neuropathy (HP:0007141)1.99236592
107Pigmentary retinal degeneration (HP:0001146)1.98387257
108Proximal tubulopathy (HP:0000114)1.98256996
109Papillary thyroid carcinoma (HP:0002895)1.98103660
110Lethargy (HP:0001254)1.97973515
111Asymmetry of the thorax (HP:0001555)1.97282911
112Symptomatic seizures (HP:0011145)1.96630235
113Epiphyseal dysplasia (HP:0002656)1.94811563
114Abnormality of purine metabolism (HP:0004352)1.94638265
115Supernumerary spleens (HP:0009799)1.94406087
116Bifid scrotum (HP:0000048)1.94023365
117Hypothermia (HP:0002045)1.92603990
118Elevated hepatic transaminases (HP:0002910)1.92603202
119Oligomenorrhea (HP:0000876)1.92393668
120Generalized aminoaciduria (HP:0002909)1.91795117
121Opisthotonus (HP:0002179)1.91720406
122Hypertriglyceridemia (HP:0002155)1.90441899
123Back pain (HP:0003418)1.88157122
124Delayed CNS myelination (HP:0002188)1.88108733
125Prolonged neonatal jaundice (HP:0006579)1.88034745
126Flat acetabular roof (HP:0003180)1.87138461
127Glomerulonephritis (HP:0000099)1.86881873
128Irregular epiphyses (HP:0010582)1.86426537
129Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.85769326
130Midline defect of the nose (HP:0004122)1.85505462
131Abnormal delivery (HP:0001787)1.83812247
132Joint swelling (HP:0001386)1.82537344
133Mitral stenosis (HP:0001718)1.81484199
134Cerebral edema (HP:0002181)1.78011514
135Blue irides (HP:0000635)1.75466042
136Anophthalmia (HP:0000528)1.74974603
137Arterial tortuosity (HP:0005116)1.74308836
138Aplasia involving bones of the upper limbs (HP:0009823)1.74304514
139Aplasia of the phalanges of the hand (HP:0009802)1.74304514
140Aplasia involving bones of the extremities (HP:0009825)1.74304514
141Prominent supraorbital ridges (HP:0000336)1.73234822
142Congenital sensorineural hearing impairment (HP:0008527)1.73190429
143Rickets (HP:0002748)1.73113137
144Coronal craniosynostosis (HP:0004440)1.71777377
145Hypoplasia of the capital femoral epiphysis (HP:0003090)1.70167346
146Decreased lacrimation (HP:0000633)1.70113338
147Absent eyebrow (HP:0002223)1.65454278
148Limited elbow extension (HP:0001377)1.65319314
149Abnormality of the nasal septum (HP:0000419)1.64619631
150Vascular tortuosity (HP:0004948)1.63520032
151Abnormality of the lacrimal duct (HP:0011481)1.63490512
152Partial duplication of thumb phalanx (HP:0009944)1.62969477
153Absent epiphyses (HP:0010577)1.62400004
154Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.62400004
155Bifid tongue (HP:0010297)1.59096664
156Abnormal foot bone ossification (HP:0010675)1.58429272
157Diastasis recti (HP:0001540)1.57687696
158Abnormality of pain sensation (HP:0010832)1.57170957
159Impaired pain sensation (HP:0007328)1.57170957
160Prenatal maternal abnormality (HP:0002686)1.56735306

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK3.82652852
2INSRR3.32744046
3IRAK32.86664219
4MAP3K142.73624999
5EIF2AK22.59141338
6PDGFRA2.45962115
7PKN22.31281227
8ZAK2.30220996
9FGFR12.21641940
10PRPF4B2.20600135
11TYRO32.17645350
12TXK2.15146172
13RIPK12.07986284
14STK38L2.07446920
15TNIK2.06211467
16PIK3CG2.04192769
17SIK12.02646891
18BCKDK2.02308169
19LATS21.92769000
20MAP2K71.90676363
21WNK41.87075347
22FRK1.84798787
23GRK11.83604960
24CAMK1D1.79531512
25NUAK11.68223544
26TAOK21.65045823
27TIE11.64745868
28WNK31.60488160
29TAOK31.59482056
30AKT31.58241237
31YES11.54882470
32ADRBK21.50101484
33SGK21.49071864
34PINK11.46404108
35DDR21.43646983
36IRAK41.42906548
37ICK1.40746888
38JAK11.39449746
39LATS11.37679807
40TEC1.36675402
41TRIB31.32812963
42MST1R1.29789927
43CDK121.26471166
44ERBB41.25251371
45EEF2K1.23053523
46RET1.22286470
47NLK1.20736558
48BMPR21.17234288
49FGFR41.15772782
50NTRK21.09113183
51SIK31.08043936
52EPHA31.07102595
53IKBKE1.06108580
54TGFBR21.04564155
55NEK61.03567807
56PRKAA21.03310116
57IKBKB1.02223313
58ERBB21.01747252
59NTRK11.01236986
60IRAK11.00713253
61WNK10.99903627
62PIK3CA0.98762992
63CDK30.96463094
64JAK30.96003304
65NEK20.92887372
66STK160.92291348
67TNK20.91061090
68NEK90.90659302
69BRSK20.88963004
70DMPK0.87150335
71SGK30.87044955
72GRK70.85485709
73TRPM70.84009798
74DYRK1B0.83107598
75MAPK70.81496646
76CAMK1G0.80245691
77MARK10.80096855
78PLK30.79057864
79MAPKAPK30.78701728
80NEK10.78454502
81STK390.77927270
82CSNK1E0.76729494
83SGK2230.76635811
84SGK4940.76635811
85TBK10.76494021
86FGFR30.73846800
87MAP3K30.73628141
88CHUK0.73104335
89PNCK0.72551856
90PKN10.72364403
91MKNK10.69458245
92PAK20.68773533
93DAPK20.67754186
94PRKCE0.67328330
95PLK20.66160020
96PDGFRB0.66029166
97PRKCG0.65197632
98TYK20.63798020
99FLT30.63177023
100MUSK0.62402144
101IRAK20.61687632
102PBK0.60537886
103LMTK20.60228032
104MAPK110.60050286
105PDK20.59605227
106STK30.58432908
107ERBB30.57041781
108MTOR0.57005250
109FGFR20.56113362
110PLK40.55103111
111TTK0.54214691
112OBSCN0.54089245
113MET0.53455863
114PDPK10.52918767
115PRKACB0.52749452
116DYRK20.51360856
117MKNK20.50807254
118RPS6KB10.50649264
119CSNK1D0.49904298
120NTRK30.49509424
121BRD40.49202237
122MAPK130.49114955
123FER0.48594353
124STK240.48312530
125CAMK2D0.47570777
126PRKAA10.47515069
127MAP3K40.46295059
128BRSK10.45571075
129MYLK0.45374979
130LYN0.45246267
131BCR0.44859741
132CDK60.44729911
133RPS6KA30.44697135
134IGF1R0.44185083
135BMPR1B0.43771977
136EPHA40.42303529
137PRKCQ0.40853901
138PRKG10.40581635
139SGK10.40142822
140JAK20.40029421
141MELK0.39971792
142PRKCZ0.39505223
143MAPK100.39454036
144CDK70.39257497
145KIT0.38804706
146CAMK2B0.38414127
147EIF2AK30.38303534
148CAMK10.36733735
149ROCK20.36665420
150PRKACG0.36644676
151EIF2AK10.36536720
152CDK80.35917438
153SRPK10.35587026
154CAMK40.35442684
155AKT20.35090185
156PRKDC0.34747656
157CSF1R0.34561825
158PRKACA0.34374895
159MAP2K30.34306346

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.72592693
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.95835469
3Tryptophan metabolism_Homo sapiens_hsa003802.64293520
4Complement and coagulation cascades_Homo sapiens_hsa046102.62398673
5Steroid hormone biosynthesis_Homo sapiens_hsa001402.58721310
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.51998314
7Pentose and glucuronate interconversions_Homo sapiens_hsa000402.51459946
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.47578508
9Fatty acid degradation_Homo sapiens_hsa000712.44649777
10beta-Alanine metabolism_Homo sapiens_hsa004102.44349606
11Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.34137604
12Peroxisome_Homo sapiens_hsa041462.28242582
13Retinol metabolism_Homo sapiens_hsa008302.26330268
14Arginine biosynthesis_Homo sapiens_hsa002202.24665868
15Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.22690438
16Staphylococcus aureus infection_Homo sapiens_hsa051502.15254729
17PPAR signaling pathway_Homo sapiens_hsa033202.15029353
18Histidine metabolism_Homo sapiens_hsa003402.12274588
19* Propanoate metabolism_Homo sapiens_hsa006402.08061650
20Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.05546761
21Chemical carcinogenesis_Homo sapiens_hsa052041.99328782
22Fatty acid metabolism_Homo sapiens_hsa012121.98972765
23Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.94842102
24Nitrogen metabolism_Homo sapiens_hsa009101.81238839
25Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.80115239
26Butanoate metabolism_Homo sapiens_hsa006501.78970357
27Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.78259995
28ABC transporters_Homo sapiens_hsa020101.76076160
29Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.73970357
30Phenylalanine metabolism_Homo sapiens_hsa003601.70524691
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.69660561
32Vitamin digestion and absorption_Homo sapiens_hsa049771.62161479
33Fatty acid elongation_Homo sapiens_hsa000621.59156611
34Drug metabolism - other enzymes_Homo sapiens_hsa009831.58317750
35Tyrosine metabolism_Homo sapiens_hsa003501.50317567
36Starch and sucrose metabolism_Homo sapiens_hsa005001.49126952
37Steroid biosynthesis_Homo sapiens_hsa001001.33512185
38Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.25827322
39Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.25395292
40Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.25009977
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.24799757
42Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.23050529
43Selenocompound metabolism_Homo sapiens_hsa004501.15883395
44Fatty acid biosynthesis_Homo sapiens_hsa000611.14113259
45Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.07185322
46Caffeine metabolism_Homo sapiens_hsa002321.06114184
47Sulfur metabolism_Homo sapiens_hsa009201.06034853
48Bile secretion_Homo sapiens_hsa049760.98063485
49Glycerolipid metabolism_Homo sapiens_hsa005610.95976926
50Pyruvate metabolism_Homo sapiens_hsa006200.94027628
51Vitamin B6 metabolism_Homo sapiens_hsa007500.90983793
52Arginine and proline metabolism_Homo sapiens_hsa003300.90866800
53One carbon pool by folate_Homo sapiens_hsa006700.89463822
54Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.88147606
55Lysine degradation_Homo sapiens_hsa003100.87067511
56Maturity onset diabetes of the young_Homo sapiens_hsa049500.85995702
57Fat digestion and absorption_Homo sapiens_hsa049750.83966302
58ECM-receptor interaction_Homo sapiens_hsa045120.80116079
59Prion diseases_Homo sapiens_hsa050200.74205598
60alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.69123715
61Autoimmune thyroid disease_Homo sapiens_hsa053200.67551160
62Arachidonic acid metabolism_Homo sapiens_hsa005900.63309236
63Cysteine and methionine metabolism_Homo sapiens_hsa002700.62710243
64Thyroid hormone synthesis_Homo sapiens_hsa049180.60654907
65Folate biosynthesis_Homo sapiens_hsa007900.60425768
66Linoleic acid metabolism_Homo sapiens_hsa005910.58701759
67* Metabolic pathways_Homo sapiens_hsa011000.53980119
68Intestinal immune network for IgA production_Homo sapiens_hsa046720.53140947
69Glucagon signaling pathway_Homo sapiens_hsa049220.52653419
70Graft-versus-host disease_Homo sapiens_hsa053320.52028928
71Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.51079549
72Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.50741223
73Glycosaminoglycan degradation_Homo sapiens_hsa005310.49208985
74Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.48264938
75NF-kappa B signaling pathway_Homo sapiens_hsa040640.47850845
76Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.47734833
77Adherens junction_Homo sapiens_hsa045200.47443961
78Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.47144992
792-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.46104265
80Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.45951532
81Basal cell carcinoma_Homo sapiens_hsa052170.45860102
82AMPK signaling pathway_Homo sapiens_hsa041520.45856465
83Glutathione metabolism_Homo sapiens_hsa004800.45507487
84Renin-angiotensin system_Homo sapiens_hsa046140.45378330
85Carbon metabolism_Homo sapiens_hsa012000.43064287
86Allograft rejection_Homo sapiens_hsa053300.42463383
87Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.39412841
88RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.39401086
89TGF-beta signaling pathway_Homo sapiens_hsa043500.37487677
90Circadian rhythm_Homo sapiens_hsa047100.37037425
91Protein digestion and absorption_Homo sapiens_hsa049740.36232510
92Hippo signaling pathway_Homo sapiens_hsa043900.36026206
93Ovarian steroidogenesis_Homo sapiens_hsa049130.35057624
94Toll-like receptor signaling pathway_Homo sapiens_hsa046200.32937971
95Fructose and mannose metabolism_Homo sapiens_hsa000510.31638556
96African trypanosomiasis_Homo sapiens_hsa051430.30293711
97Tight junction_Homo sapiens_hsa045300.29502366
98Sulfur relay system_Homo sapiens_hsa041220.29176506
99Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.29042481
100Wnt signaling pathway_Homo sapiens_hsa043100.28669556
101Dilated cardiomyopathy_Homo sapiens_hsa054140.27210572
102Cyanoamino acid metabolism_Homo sapiens_hsa004600.26500788
103N-Glycan biosynthesis_Homo sapiens_hsa005100.24723189
104Insulin signaling pathway_Homo sapiens_hsa049100.24722556
105Central carbon metabolism in cancer_Homo sapiens_hsa052300.24085507
106Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.23467394
107Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.23109570
108Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.23062613
109Malaria_Homo sapiens_hsa051440.22898460
110Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.21873395
111Galactose metabolism_Homo sapiens_hsa000520.20999282
112Biosynthesis of amino acids_Homo sapiens_hsa012300.20449600
113Glycerophospholipid metabolism_Homo sapiens_hsa005640.20230605
114Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.19853618
115TNF signaling pathway_Homo sapiens_hsa046680.19838297
116Regulation of autophagy_Homo sapiens_hsa041400.19036594
117Adipocytokine signaling pathway_Homo sapiens_hsa049200.18951982
118Focal adhesion_Homo sapiens_hsa045100.18865629
119Rheumatoid arthritis_Homo sapiens_hsa053230.18152534
120Mineral absorption_Homo sapiens_hsa049780.17137626
121Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.16742540
122Hedgehog signaling pathway_Homo sapiens_hsa043400.16488574
123Hematopoietic cell lineage_Homo sapiens_hsa046400.15767816
124Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.15525803
125Sphingolipid metabolism_Homo sapiens_hsa006000.13912305
126Fanconi anemia pathway_Homo sapiens_hsa034600.13895151
127Jak-STAT signaling pathway_Homo sapiens_hsa046300.13834670
128Proteoglycans in cancer_Homo sapiens_hsa052050.13588629
129Measles_Homo sapiens_hsa051620.13139873
130Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.12661456
131Axon guidance_Homo sapiens_hsa043600.12298016
132Insulin resistance_Homo sapiens_hsa049310.11583414
133NOD-like receptor signaling pathway_Homo sapiens_hsa046210.10996552
134Pentose phosphate pathway_Homo sapiens_hsa000300.10355995

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