ACTB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes one of six different actin proteins. Actins are highly conserved proteins that are involved in cell motility, structure, and integrity. This actin is a major constituent of the contractile apparatus and one of the two nonmuscle cytoskeletal actins. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of viral latency (GO:0019043)4.12345570
2sequestering of actin monomers (GO:0042989)4.09485277
3Arp2/3 complex-mediated actin nucleation (GO:0034314)4.05696714
4establishment of integrated proviral latency (GO:0075713)4.02435317
5antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.97505276
6modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.91929651
7positive regulation by organism of defense response of other organism involved in symbiotic interact3.91929651
8modulation by symbiont of host immune response (GO:0052553)3.91929651
9positive regulation by symbiont of host defense response (GO:0052509)3.91929651
10modulation by symbiont of host defense response (GO:0052031)3.91929651
11modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.91929651
12negative regulation of cell killing (GO:0031342)3.85478082
13negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.85478082
14neutrophil activation involved in immune response (GO:0002283)3.84904173
15ribosomal small subunit assembly (GO:0000028)3.72271851
16antigen processing and presentation of endogenous antigen (GO:0019883)3.51589845
17immunoglobulin mediated immune response (GO:0016064)3.26199558
18antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.22470448
19antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.22470448
20NIK/NF-kappaB signaling (GO:0038061)3.18361036
21response to interferon-beta (GO:0035456)3.16500515
22positive regulation of gamma-delta T cell activation (GO:0046645)3.16383293
23cellular response to interferon-beta (GO:0035458)3.13821424
24COPI coating of Golgi vesicle (GO:0048205)3.12514374
25Golgi transport vesicle coating (GO:0048200)3.12514374
26chaperone mediated protein folding requiring cofactor (GO:0051085)3.10967423
27detection of bacterium (GO:0016045)3.10243605
28regulation of defense response to virus by virus (GO:0050690)3.08659898
29pentose-phosphate shunt (GO:0006098)3.07526110
30protein maturation by protein folding (GO:0022417)3.07250721
31positive regulation of interferon-alpha production (GO:0032727)3.06833219
32B cell mediated immunity (GO:0019724)3.06514433
33myeloid dendritic cell activation (GO:0001773)3.03819716
34detection of other organism (GO:0098543)3.02977019
35NADPH regeneration (GO:0006740)3.01581891
36negative regulation of phagocytosis (GO:0050765)3.01467669
37positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.01100262
38actin nucleation (GO:0045010)3.00420691
39neutrophil activation (GO:0042119)2.99264227
40regulation of dendritic cell antigen processing and presentation (GO:0002604)2.95397067
41cellular response to type I interferon (GO:0071357)2.95066480
42type I interferon signaling pathway (GO:0060337)2.95066480
43positive regulation of antigen processing and presentation (GO:0002579)2.91715895
44response to type I interferon (GO:0034340)2.90935971
45antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.89755811
46regulation of interferon-alpha production (GO:0032647)2.88694014
47cellular response to zinc ion (GO:0071294)2.87519889
48regulation of B cell receptor signaling pathway (GO:0050855)2.85044255
49negative thymic T cell selection (GO:0045060)2.84737287
50natural killer cell mediated immunity (GO:0002228)2.82586842
51natural killer cell mediated cytotoxicity (GO:0042267)2.82586842
52antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.81279825
53interferon-gamma-mediated signaling pathway (GO:0060333)2.80810279
54regulation of antigen processing and presentation (GO:0002577)2.80586098
55telomere maintenance via semi-conservative replication (GO:0032201)2.80130680
56response to peptidoglycan (GO:0032494)2.79556809
57dendritic cell chemotaxis (GO:0002407)2.79077815
58negative T cell selection (GO:0043383)2.78564742
59positive regulation of natural killer cell differentiation (GO:0032825)2.76000654
60mitotic nuclear envelope reassembly (GO:0007084)2.74624751
61nuclear envelope reassembly (GO:0031468)2.74624751
62positive regulation of alpha-beta T cell proliferation (GO:0046641)2.74514529
63granulocyte activation (GO:0036230)2.73485392
64B cell receptor signaling pathway (GO:0050853)2.71015112
65negative regulation of B cell apoptotic process (GO:0002903)2.70636803
66telomere maintenance via recombination (GO:0000722)2.70482569
67regulation of RIG-I signaling pathway (GO:0039535)2.69915766
68peptidyl-arginine omega-N-methylation (GO:0035247)2.69794515
69regulation of T-helper 1 cell differentiation (GO:0045625)2.68708851
70defense response to protozoan (GO:0042832)2.67510893
71myeloid dendritic cell differentiation (GO:0043011)2.65975620
72positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.65716107
73regulation of alpha-beta T cell proliferation (GO:0046640)2.65715387
74response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.65149188
75response to host immune response (GO:0052572)2.65149188
76positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.62121160
77negative regulation of ligase activity (GO:0051352)2.61457813
78negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.61457813
79DNA strand elongation involved in DNA replication (GO:0006271)2.60756543
80cellular response to interleukin-4 (GO:0071353)2.60145900
81regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.59850742
82response to interleukin-15 (GO:0070672)2.59517317
83response to muramyl dipeptide (GO:0032495)2.59371526
84regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.58745051
85negative regulation of interleukin-12 production (GO:0032695)2.57812620
86interferon-gamma production (GO:0032609)2.57725084
87positive thymic T cell selection (GO:0045059)2.57218884
88leukocyte aggregation (GO:0070486)2.57063976
89cellular response to interleukin-15 (GO:0071350)2.56273830
90activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.55812774
91negative regulation of viral genome replication (GO:0045071)2.55205475
92respiratory burst (GO:0045730)2.55103063
93positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.54250145
94response to interferon-alpha (GO:0035455)2.54143876
95response to protozoan (GO:0001562)2.53669061
96positive regulation of lamellipodium assembly (GO:0010592)2.53458732
97positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.53171991
98dendritic cell migration (GO:0036336)2.53102635
99regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.52962869
100positive regulation of T cell mediated cytotoxicity (GO:0001916)2.52510281
101regulation of cellular amino acid metabolic process (GO:0006521)2.52436611
102regulation of interferon-beta biosynthetic process (GO:0045357)2.51904557
103thymic T cell selection (GO:0045061)2.51730731
104DNA strand elongation (GO:0022616)2.50224304
105positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.50062165
106T cell migration (GO:0072678)2.49926226
107regulation of B cell differentiation (GO:0045577)2.49334677
108response to host (GO:0075136)2.49328517
109response to host defenses (GO:0052200)2.49328517
110response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.49328517
111positive regulation of macrophage differentiation (GO:0045651)2.49213730
112mitotic recombination (GO:0006312)2.44987410
113positive regulation of interleukin-12 production (GO:0032735)2.43393127
114anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.42386149
115membrane raft organization (GO:0031579)2.41343158
116positive regulation of T cell chemotaxis (GO:0010820)2.41127177
117regulation of T cell chemotaxis (GO:0010819)2.41127177
118DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.40978584
119antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.40749090
120positive regulation of isotype switching (GO:0045830)2.40532884
121mast cell activation (GO:0045576)2.39796356
122cellular response to exogenous dsRNA (GO:0071360)2.39690797
123proteasome assembly (GO:0043248)2.38943265
124dendritic cell differentiation (GO:0097028)2.37657182
125negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.37525236
126DNA deamination (GO:0045006)2.37369535
127signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.37224926
128signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.37224926
129signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.37224926
130hepatocyte apoptotic process (GO:0097284)2.36993620
131intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.36820645
132signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.36820645
133natural killer cell activation (GO:0030101)2.36713616
134lymphocyte mediated immunity (GO:0002449)2.34750435
135regulation of interleukin-12 biosynthetic process (GO:0045075)2.34190396
136barbed-end actin filament capping (GO:0051016)2.33920913
137negative regulation of leukocyte mediated immunity (GO:0002704)2.33496083
138negative regulation of lymphocyte mediated immunity (GO:0002707)2.33321934
139regulation of protein heterodimerization activity (GO:0043497)2.33270831
140negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.33037846
141regulation of T cell mediated cytotoxicity (GO:0001914)2.33020427
142positive regulation of T cell migration (GO:2000406)2.29916236
143positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.29545560
144leukocyte mediated cytotoxicity (GO:0001909)2.29389009
145positive regulation of protein import into nucleus, translocation (GO:0033160)2.29310148
146positive regulation of interferon-beta production (GO:0032728)2.28789425
147regulation of T cell migration (GO:2000404)2.27414313
148positive regulation of B cell differentiation (GO:0045579)2.25767735
149positive regulation of interleukin-2 production (GO:0032743)2.25239195
150signal transduction involved in DNA integrity checkpoint (GO:0072401)2.24572393
151signal transduction involved in DNA damage checkpoint (GO:0072422)2.24572393
152regulation of response to interferon-gamma (GO:0060330)2.24124552
153signal transduction involved in cell cycle checkpoint (GO:0072395)2.23759505
154deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.23619591

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.76808303
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.57069950
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.21675045
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.75215280
5* IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.58858642
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.15416808
7* SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.92373772
8EGR1_19374776_ChIP-ChIP_THP-1_Human2.88668146
9ELF1_17652178_ChIP-ChIP_JURKAT_Human2.62066176
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.56232671
11EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.55697312
12STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.55449738
13STAT4_19710469_ChIP-ChIP_TH1__Mouse2.54582591
14E2F4_17652178_ChIP-ChIP_JURKAT_Human2.48741092
15SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.48555883
16IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.42613743
17MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.32940710
18* MYC_18555785_ChIP-Seq_MESCs_Mouse2.30065372
19IRF8_27001747_Chip-Seq_BMDM_Mouse2.23173154
20GABP_17652178_ChIP-ChIP_JURKAT_Human2.20924269
21* STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.15264395
22SPI1_23547873_ChIP-Seq_NB4_Human2.15215117
23MYB_21317192_ChIP-Seq_ERMYB_Mouse2.09646868
24FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.09507765
25* FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.08369448
26EST1_17652178_ChIP-ChIP_JURKAT_Human2.08070919
27KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.06999610
28ELK1_19687146_ChIP-ChIP_HELA_Human2.04353561
29FOXM1_23109430_ChIP-Seq_U2OS_Human2.02064173
30ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.01879392
31* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.97696896
32NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.94920656
33* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.90179429
34* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.87032104
35* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.85742951
36VDR_23849224_ChIP-Seq_CD4+_Human1.82999918
37HOXB4_20404135_ChIP-ChIP_EML_Mouse1.82473131
38* MYB_26560356_Chip-Seq_TH2_Human1.81451119
39RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.77860675
40CREB1_15753290_ChIP-ChIP_HEK293T_Human1.72706359
41JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.65279988
42THAP11_20581084_ChIP-Seq_MESCs_Mouse1.62807157
43SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.62611846
44* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.62398634
45* ELK3_25401928_ChIP-Seq_HUVEC_Human1.62280540
46* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.62076642
47TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.59820074
48RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.59683275
49MYB_26560356_Chip-Seq_TH1_Human1.59624357
50NOTCH1_21737748_ChIP-Seq_TLL_Human1.59162033
51MYC_18358816_ChIP-ChIP_MESCs_Mouse1.56909549
52MAF_26560356_Chip-Seq_TH1_Human1.56428970
53SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.54204650
54ETS1_20019798_ChIP-Seq_JURKAT_Human1.48909906
55ERG_20887958_ChIP-Seq_HPC-7_Mouse1.47453697
56MYC_22102868_ChIP-Seq_BL_Human1.45761848
57RUNX1_22412390_ChIP-Seq_EML_Mouse1.44364833
58* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.42309597
59FOXP3_21729870_ChIP-Seq_TREG_Human1.42032150
60DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.41902758
61* XRN2_22483619_ChIP-Seq_HELA_Human1.41629856
62FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.41463189
63* MYC_19079543_ChIP-ChIP_MESCs_Mouse1.41335286
64DCP1A_22483619_ChIP-Seq_HELA_Human1.37621148
65E2F1_21310950_ChIP-Seq_MCF-7_Human1.37516855
66CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.33320775
67PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.33224518
68* VDR_21846776_ChIP-Seq_THP-1_Human1.32839704
69BRD4_27068464_Chip-Seq_AML-cells_Mouse1.30207434
70SCL_19346495_ChIP-Seq_HPC-7_Human1.30138166
71* VDR_24763502_ChIP-Seq_THP-1_Human1.30078426
72MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.29812929
73* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.29608415
74* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.27448760
75ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.25472523
76SRF_21415370_ChIP-Seq_HL-1_Mouse1.25161159
77GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.24176271
78TP63_17297297_ChIP-ChIP_HaCaT_Human1.23941180
79* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.23743744
80POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.22509276
81NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.22363087
82RUNX_20019798_ChIP-Seq_JUKART_Human1.22186989
83FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.21867364
84E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.21494789
85* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.20185964
86* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.19774868
87POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.19084257
88CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.17093244
89MYCN_18555785_ChIP-Seq_MESCs_Mouse1.16659283
90HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.16447897
91HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.15745960
92* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.14590263
93* YY1_21170310_ChIP-Seq_MESCs_Mouse1.14333858
94SRY_22984422_ChIP-ChIP_TESTIS_Rat1.12723888
95* UTX_26944678_Chip-Seq_JUKART_Human1.12682095
96TP63_19390658_ChIP-ChIP_HaCaT_Human1.12275317
97* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.10882255
98GATA1_22383799_ChIP-Seq_G1ME_Mouse1.10078124
99* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.08734006
100PU_27001747_Chip-Seq_BMDM_Mouse1.08454265
101* TTF2_22483619_ChIP-Seq_HELA_Human1.08402743
102ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.07492035
103KLF4_18555785_ChIP-Seq_MESCs_Mouse1.06699096
104SPI1_23127762_ChIP-Seq_K562_Human1.05848006
105* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.05614399
106* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04811279
107ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.04350140
108CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04335570
109TFEB_21752829_ChIP-Seq_HELA_Human1.03613704
110PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03456697
111SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02717608
112* TCF7_22412390_ChIP-Seq_EML_Mouse1.02571897
113* ELK1_22589737_ChIP-Seq_MCF10A_Human1.02024754
114GATA2_22383799_ChIP-Seq_G1ME_Mouse1.01254276
115CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00511691
116Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.00196060
117* GABP_19822575_ChIP-Seq_HepG2_Human0.99666876
118* MAF_26560356_Chip-Seq_TH2_Human0.97738242
119* CIITA_25753668_ChIP-Seq_RAJI_Human0.96985758
120TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.96417523
121* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.96191006
122GATA3_27048872_Chip-Seq_THYMUS_Human0.90655282
123* LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.90270737
124CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.89580210
125NANOG_18555785_ChIP-Seq_MESCs_Mouse0.89227251
126CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.89091381
127AR_21909140_ChIP-Seq_LNCAP_Human0.88859307
128* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.88313992

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.45219663
2MP0002148_abnormal_hypersensitivity_rea3.23439847
3MP0005671_abnormal_response_to3.18460018
4MP0009785_altered_susceptibility_to3.08349922
5MP0000685_abnormal_immune_system2.93771663
6MP0008260_abnormal_autophagy2.84719560
7MP0003436_decreased_susceptibility_to2.77445952
8MP0005000_abnormal_immune_tolerance2.65237838
9MP0001790_abnormal_immune_system2.50202013
10MP0005387_immune_system_phenotype2.50202013
11MP0003763_abnormal_thymus_physiology2.49313486
12MP0002452_abnormal_antigen_presenting2.47222532
13MP0001800_abnormal_humoral_immune2.43919660
14MP0005025_abnormal_response_to2.39828142
15MP0002396_abnormal_hematopoietic_system2.30108037
16MP0001819_abnormal_immune_cell2.29192268
17MP0002420_abnormal_adaptive_immunity2.28710114
18MP0002419_abnormal_innate_immunity2.28374306
19MP0002723_abnormal_immune_serum2.27508424
20MP0009333_abnormal_splenocyte_physiolog2.21025262
21MP0002166_altered_tumor_susceptibility2.11665956
22MP0008007_abnormal_cellular_replicative2.09817603
23MP0002398_abnormal_bone_marrow2.03896696
24MP0002405_respiratory_system_inflammati2.01871138
25MP0002006_tumorigenesis2.01851906
26MP0003724_increased_susceptibility_to1.97677385
27MP0001853_heart_inflammation1.95658488
28MP0003300_gastrointestinal_ulcer1.91366922
29MP0000716_abnormal_immune_system1.84462439
30MP0003693_abnormal_embryo_hatching1.81070075
31MP0006082_CNS_inflammation1.77299760
32MP0000858_altered_metastatic_potential1.75551517
33MP0004808_abnormal_hematopoietic_stem1.73728686
34MP0008057_abnormal_DNA_replication1.69914862
35MP0003191_abnormal_cellular_cholesterol1.68019571
36MP0000689_abnormal_spleen_morphology1.66315335
37MP0010094_abnormal_chromosome_stability1.65171803
38MP0010155_abnormal_intestine_physiology1.64431879
39MP0003077_abnormal_cell_cycle1.63039466
40MP0002722_abnormal_immune_system1.62810405
41MP0002429_abnormal_blood_cell1.59339624
42MP0001545_abnormal_hematopoietic_system1.53830643
43MP0005397_hematopoietic_system_phenotyp1.53830643
44MP0005464_abnormal_platelet_physiology1.50199609
45MP0003806_abnormal_nucleotide_metabolis1.50037772
46MP0000490_abnormal_crypts_of1.49545933
47MP0003448_altered_tumor_morphology1.48827400
48MP0001845_abnormal_inflammatory_respons1.44162960
49MP0004510_myositis1.39966223
50MP0005451_abnormal_body_composition1.39752713
51MP0008058_abnormal_DNA_repair1.38981316
52MP0000703_abnormal_thymus_morphology1.38474332
53MP0001533_abnormal_skeleton_physiology1.37056144
54MP0006054_spinal_hemorrhage1.34593442
55MP0010352_gastrointestinal_tract_polyps1.33543750
56MP0003111_abnormal_nucleus_morphology1.31181239
57MP0003303_peritoneal_inflammation1.30818002
58MP0002163_abnormal_gland_morphology1.26742656
59MP0001849_ear_inflammation1.24631656
60MP0004957_abnormal_blastocyst_morpholog1.23886167
61MP0005623_abnormal_meninges_morphology1.21542181
62MP0003221_abnormal_cardiomyocyte_apopto1.21066239
63MP0004947_skin_inflammation1.16818528
64MP0003279_aneurysm1.14813026
65MP0010307_abnormal_tumor_latency1.13489394
66MP0002009_preneoplasia1.13312579
67MP0000343_altered_response_to1.13078493
68MP0003186_abnormal_redox_activity1.10973157
69MP0002877_abnormal_melanocyte_morpholog1.07963685
70MP0001873_stomach_inflammation1.06880626
71MP0000358_abnormal_cell_content/1.05926161
72MP0006035_abnormal_mitochondrial_morpho1.05763041
73MP0008469_abnormal_protein_level1.03526175
74* MP0002019_abnormal_tumor_incidence1.03166380
75MP0001730_embryonic_growth_arrest1.03015172
76MP0005621_abnormal_cell_physiology1.02890540
77MP0005310_abnormal_salivary_gland1.01361266
78MP0003075_altered_response_to1.01194083
79MP0002933_joint_inflammation1.00812742
80MP0001348_abnormal_lacrimal_gland0.98664599
81MP0005174_abnormal_tail_pigmentation0.97375180
82MP0003786_premature_aging0.97296194
83MP0003566_abnormal_cell_adhesion0.95262689
84MP0000465_gastrointestinal_hemorrhage0.93946965
85MP0002132_abnormal_respiratory_system0.93236352
86MP0008438_abnormal_cutaneous_collagen0.92895220
87MP0009764_decreased_sensitivity_to0.92572333
88MP0005384_cellular_phenotype0.91796963
89MP0000015_abnormal_ear_pigmentation0.91386248
90MP0003866_abnormal_defecation0.91311518
91MP0009763_increased_sensitivity_to0.90272215
92MP0008932_abnormal_embryonic_tissue0.88954386
93MP0005023_abnormal_wound_healing0.88713565
94MP0005390_skeleton_phenotype0.87095377
95MP0005058_abnormal_lysosome_morphology0.87035088
96MP0003943_abnormal_hepatobiliary_system0.87007068
97MP0009379_abnormal_foot_pigmentation0.86459915
98MP0001542_abnormal_bone_strength0.86194437
99MP0002277_abnormal_respiratory_mucosa0.85249153
100MP0004782_abnormal_surfactant_physiolog0.85036764
101MP0001879_abnormal_lymphatic_vessel0.84334493
102MP0004883_abnormal_blood_vessel0.81593116
103MP0000313_abnormal_cell_death0.81361767
104MP0000350_abnormal_cell_proliferation0.81058277
105MP0005075_abnormal_melanosome_morpholog0.80153869
106MP0001915_intracranial_hemorrhage0.79510759
107MP0005501_abnormal_skin_physiology0.79200957
108MP0003941_abnormal_skin_development0.78570129
109MP0002095_abnormal_skin_pigmentation0.78050325
110MP0003828_pulmonary_edema0.77864912
111MP0002998_abnormal_bone_remodeling0.77604766
112MP0003172_abnormal_lysosome_physiology0.77550643
113* MP0002080_prenatal_lethality0.76454441
114MP0003091_abnormal_cell_migration0.75718853
115MP0003705_abnormal_hypodermis_morpholog0.75536932
116MP0005076_abnormal_cell_differentiation0.73964607
117MP0000372_irregular_coat_pigmentation0.73083142
118MP0002138_abnormal_hepatobiliary_system0.71901726
119MP0002254_reproductive_system_inflammat0.71369645
120MP0009278_abnormal_bone_marrow0.71319894
121MP0001851_eye_inflammation0.70723521
122MP0001529_abnormal_vocalization0.70594587
123MP0005165_increased_susceptibility_to0.69806332
124MP0001243_abnormal_dermal_layer0.69750394
125MP0001958_emphysema0.68096988
126MP0001727_abnormal_embryo_implantation0.66661483
127MP0000371_diluted_coat_color0.58254589

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)4.93048298
2Elevated erythrocyte sedimentation rate (HP:0003565)4.59032970
3Eczematoid dermatitis (HP:0000976)4.49577883
4Recurrent bacterial skin infections (HP:0005406)4.30044971
5Myositis (HP:0100614)4.11576975
6Mediastinal lymphadenopathy (HP:0100721)3.51980896
7Thrombocytosis (HP:0001894)3.40070382
8Increased IgM level (HP:0003496)3.37992756
9Recurrent fungal infections (HP:0002841)3.19807823
10Retrobulbar optic neuritis (HP:0100654)3.18941091
11Optic neuritis (HP:0100653)3.18941091
12Cholecystitis (HP:0001082)3.18903585
13Abnormal gallbladder physiology (HP:0012438)3.18903585
14Orchitis (HP:0100796)3.18272963
15Recurrent viral infections (HP:0004429)3.07106515
16Autoimmune thrombocytopenia (HP:0001973)3.03957407
17Petechiae (HP:0000967)2.99560672
18Abnormality of macrophages (HP:0004311)2.98114339
19IgM deficiency (HP:0002850)2.95481854
20Hepatosplenomegaly (HP:0001433)2.94940140
21Urticaria (HP:0001025)2.91658191
22Obstructive lung disease (HP:0006536)2.89707070
23Chronic obstructive pulmonary disease (HP:0006510)2.89707070
24Spinal cord lesions (HP:0100561)2.85859344
25Syringomyelia (HP:0003396)2.85859344
26Chronic otitis media (HP:0000389)2.81490093
27Recurrent skin infections (HP:0001581)2.77851019
28Abnormality of T cell number (HP:0011839)2.77306694
29Vasculitis (HP:0002633)2.76272052
30Eosinophilia (HP:0001880)2.73437292
31Granulocytopenia (HP:0001913)2.70072619
32Poor head control (HP:0002421)2.69270207
33Cellulitis (HP:0100658)2.68562188
34Chest pain (HP:0100749)2.65026945
35Meningitis (HP:0001287)2.64955886
36Abnormality of T cells (HP:0002843)2.61258994
37IgG deficiency (HP:0004315)2.60940890
38Abnormality of the anterior horn cell (HP:0006802)2.60771929
39Degeneration of anterior horn cells (HP:0002398)2.60771929
40Cortical dysplasia (HP:0002539)2.60217586
41Hypertensive crisis (HP:0100735)2.59599886
42Recurrent gram-negative bacterial infections (HP:0005420)2.59429489
43Recurrent bronchitis (HP:0002837)2.57103661
44Leukocytosis (HP:0001974)2.55748442
45Hypergammaglobulinemia (HP:0010702)2.52577423
46Increased mean platelet volume (HP:0011877)2.50074188
47Basal ganglia calcification (HP:0002135)2.49427046
48Gastrointestinal stroma tumor (HP:0100723)2.47587423
49Rough bone trabeculation (HP:0100670)2.47312527
50Abnormality of T cell physiology (HP:0011840)2.47163407
51T lymphocytopenia (HP:0005403)2.46734483
52Vertebral compression fractures (HP:0002953)2.45470712
53Recurrent pneumonia (HP:0006532)2.45256824
54Recurrent cutaneous fungal infections (HP:0011370)2.43988129
55Chronic mucocutaneous candidiasis (HP:0002728)2.43988129
56Reticulocytopenia (HP:0001896)2.42535004
5711 pairs of ribs (HP:0000878)2.42356805
58Spastic diplegia (HP:0001264)2.40816918
59Abnormality of cells of the lymphoid lineage (HP:0012140)2.38218671
60Abnormality of eosinophils (HP:0001879)2.37942795
61Sepsis (HP:0100806)2.36534089
62Aplastic anemia (HP:0001915)2.34752649
63Pustule (HP:0200039)2.34032584
64Agammaglobulinemia (HP:0004432)2.33344453
65Abnormal delayed hypersensitivity skin test (HP:0002963)2.31959399
66Prostate neoplasm (HP:0100787)2.30719298
67Keratoconjunctivitis sicca (HP:0001097)2.30316652
68Increased IgE level (HP:0003212)2.30165400
69IgA deficiency (HP:0002720)2.30012849
70Lymphopenia (HP:0001888)2.27940658
71Lymphoma (HP:0002665)2.27675929
72Pulmonary infiltrates (HP:0002113)2.26795749
73Upper limb muscle weakness (HP:0003484)2.26729793
74Severe combined immunodeficiency (HP:0004430)2.25367176
75Abnormality of the prostate (HP:0008775)2.25128811
76Entropion (HP:0000621)2.24420392
77Verrucae (HP:0200043)2.23254517
78Papilloma (HP:0012740)2.23254517
79Recurrent lower respiratory tract infections (HP:0002783)2.21024365
80Amyotrophic lateral sclerosis (HP:0007354)2.20551409
81Periodontitis (HP:0000704)2.17919647
82Pelvic girdle muscle weakness (HP:0003749)2.16108380
83Keratoconjunctivitis (HP:0001096)2.16085184
84Chromsome breakage (HP:0040012)2.15263857
85Spontaneous hematomas (HP:0007420)2.14789412
86Gingivitis (HP:0000230)2.14515275
87Agnosia (HP:0010524)2.13090461
88Distal lower limb amyotrophy (HP:0008944)2.12140902
89Microvesicular hepatic steatosis (HP:0001414)2.10967501
90Osteolytic defects of the phalanges of the hand (HP:0009771)2.10663639
91Osteolytic defects of the hand bones (HP:0009699)2.10663639
92Encephalitis (HP:0002383)2.10145758
93Epistaxis (HP:0000421)2.09141817
94Combined immunodeficiency (HP:0005387)2.08989390
95Osteomyelitis (HP:0002754)2.08100046
96Bilateral sensorineural hearing impairment (HP:0008619)2.07034775
97Panhypogammaglobulinemia (HP:0003139)2.05216821
98Premature loss of primary teeth (HP:0006323)2.04522964
99Prolonged bleeding time (HP:0003010)2.02621241
100Gastrointestinal infarctions (HP:0005244)2.01846106
101Shoulder girdle muscle weakness (HP:0003547)2.01775052
102Interstitial pulmonary disease (HP:0006530)2.01697791
103Autoimmune hemolytic anemia (HP:0001890)1.99719772
104Hemoptysis (HP:0002105)1.99305817
105Abnormality of the hip-girdle musculature (HP:0001445)1.97108266
106Abnormality of the musculature of the pelvis (HP:0001469)1.97108266
107Amaurosis fugax (HP:0100576)1.96485032
108Skin ulcer (HP:0200042)1.95891004
109Gastrointestinal inflammation (HP:0004386)1.95386978
110Type I transferrin isoform profile (HP:0003642)1.94547040
111Chromosomal breakage induced by crosslinking agents (HP:0003221)1.94469321
112Thyroiditis (HP:0100646)1.94425662
113Chronic diarrhea (HP:0002028)1.93883306
114Arterial thrombosis (HP:0004420)1.93013290
115Increased density of long bones (HP:0006392)1.92239834
116Skin rash (HP:0000988)1.92063840
117Glomerulopathy (HP:0100820)1.91510916
118Pulmonary fibrosis (HP:0002206)1.90638406
119Premature rupture of membranes (HP:0001788)1.89852467
120Reduced subcutaneous adipose tissue (HP:0003758)1.89507580
121Selective tooth agenesis (HP:0001592)1.89452305
122Inflammation of the large intestine (HP:0002037)1.87163125
123Micronodular cirrhosis (HP:0001413)1.87017379
124Stomatitis (HP:0010280)1.86998305
125Birth length less than 3rd percentile (HP:0003561)1.86772886
126Viral hepatitis (HP:0006562)1.85431499
127Atrophy/Degeneration involving motor neurons (HP:0007373)1.84988319
128Vacuolated lymphocytes (HP:0001922)1.83837854
129Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.83476165
130Abnormal neuron morphology (HP:0012757)1.80774519
131Abnormality of the motor neurons (HP:0002450)1.80774519
132Reduced antithrombin III activity (HP:0001976)1.80769590
133Acute hepatic failure (HP:0006554)1.80492817
134Recurrent sinusitis (HP:0011108)1.79499201
135Abnormal number of erythroid precursors (HP:0012131)1.79381805
136Impaired platelet aggregation (HP:0003540)1.79376494
137Abnormal platelet function (HP:0011869)1.79376494
138Abnormal platelet volume (HP:0011876)1.79310407
139Cleft eyelid (HP:0000625)1.79089695
140Abnormality of the pleura (HP:0002103)1.78697949
141Clubbing of toes (HP:0100760)1.77244223
142Acute myeloid leukemia (HP:0004808)1.75731762
143B lymphocytopenia (HP:0010976)1.75713085
144Abnormality of B cell number (HP:0010975)1.75713085
145Exertional dyspnea (HP:0002875)1.75655364
146Aplasia/Hypoplasia of the sacrum (HP:0008517)1.73415526

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK23.78311268
2MAP3K143.73431694
3SMG12.87967128
4PIM22.80802872
5IRAK42.73352840
6MAP4K12.68357542
7TXK2.58584842
8JAK32.34725069
9TESK12.30491104
10TESK22.29162829
11BLK2.28591651
12NME22.25105712
13EIF2AK12.15945955
14TBK12.07695729
15TYK22.04913556
16BUB12.04177289
17IKBKE1.98974698
18IKBKB1.93960860
19KIT1.87984476
20PRPF4B1.75611782
21ERBB31.72369029
22IRAK31.72054555
23ERN11.70023298
24EPHB11.64825376
25SIK31.64750212
26RPS6KA41.63739074
27ZAK1.63273275
28KDR1.55996829
29TRIM281.53172977
30BCKDK1.51984570
31PIM11.47732990
32ZAP701.46118292
33NEK91.45426311
34TEC1.44131101
35CHUK1.42774312
36BTK1.36943764
37MST41.36090444
38TGFBR11.34322439
39VRK11.33641236
40MKNK11.32681187
41DAPK11.32639904
42PBK1.31822414
43WEE11.28123643
44STK101.26813712
45LIMK11.25299630
46CLK11.24273627
47EIF2AK31.22755834
48EIF2AK21.22516036
49PLK41.21583365
50SYK1.21447647
51NEK11.16543159
52BMPR21.16231368
53CSF1R1.15876310
54CDK191.15029890
55TLK11.14998035
56SRPK11.13576145
57ACVR1B1.12152854
58ARAF1.11277253
59TAF11.09702792
60TRPM71.08301863
61STK161.07389148
62STK41.05944246
63FES1.01013815
64NLK1.00719552
65FGR0.98735009
66CDC70.95855899
67LCK0.94510585
68LYN0.90935973
69TTN0.88107250
70MAP3K120.87715203
71TSSK60.86575625
72NUAK10.83402551
73LRRK20.80342943
74JAK10.80328319
75CSK0.79670561
76ITK0.79164185
77YES10.78717709
78BRSK20.77572128
79ATR0.76616540
80AURKA0.75884765
81CSNK1G30.75026705
82GRK60.74054727
83FLT30.74043659
84HCK0.73219949
85TAOK10.71577955
86BMPR1B0.71134654
87RIPK40.67620928
88PAK40.66147700
89MAPKAPK20.66021612
90ALK0.65404842
91RPS6KB20.64922425
92CDK140.63289904
93DAPK30.62610850
94DYRK20.60950870
95TAOK20.60538435
96RPS6KA50.60431131
97CSNK1A1L0.58228451
98AURKB0.57379712
99RPS6KA60.56860822
100PLK30.55728274
101EPHA30.55466976
102ABL20.54909602
103MAP2K30.54092703
104MAP3K80.52293136
105FGFR30.52236819
106CDK70.52056992
107TGFBR20.51097308
108PRKCD0.51016846
109EPHA20.50796863
110MOS0.50062636
111ERBB40.49982593
112MAP3K50.47883408
113CDK180.47800247
114CDK40.47710217
115MKNK20.47631314
116MYLK0.47618201
117MATK0.47428425
118RPS6KL10.47089094
119RPS6KC10.47089094
120ROCK20.46748413
121MAP3K110.45765453
122PASK0.44531465
123ADRBK20.43789917
124MAP2K70.43516337
125SCYL20.43469225
126PLK10.43067907
127RAF10.42772021
128MAP3K30.42618409
129CDK80.41891304
130CCNB10.41421032
131CDK150.40283817
132PTK60.40266018
133CDK11A0.39916009
134BCR0.37940214
135CSNK1G20.35729682
136PAK10.35537291
137JAK20.35151454
138PRKD20.33838898
139FYN0.32299372
140CDK90.32189693
141PRKCQ0.30183429

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030302.84278393
2Proteasome_Homo sapiens_hsa030502.81775853
3Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.55703278
4Allograft rejection_Homo sapiens_hsa053302.51862670
5Graft-versus-host disease_Homo sapiens_hsa053322.40543145
6Primary immunodeficiency_Homo sapiens_hsa053402.18720695
7Leishmaniasis_Homo sapiens_hsa051402.13579318
8Mismatch repair_Homo sapiens_hsa034302.12209435
9Ribosome_Homo sapiens_hsa030102.05409295
10NF-kappa B signaling pathway_Homo sapiens_hsa040642.02996705
11Intestinal immune network for IgA production_Homo sapiens_hsa046722.02284484
12Measles_Homo sapiens_hsa051622.01597298
13Base excision repair_Homo sapiens_hsa034101.97629190
14Antigen processing and presentation_Homo sapiens_hsa046121.85990010
15Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.79757064
16Legionellosis_Homo sapiens_hsa051341.75504927
17* Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.69062421
18Herpes simplex infection_Homo sapiens_hsa051681.68103887
19Homologous recombination_Homo sapiens_hsa034401.64796646
20Pentose phosphate pathway_Homo sapiens_hsa000301.63192483
21RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.61134048
22Toll-like receptor signaling pathway_Homo sapiens_hsa046201.60776103
23Spliceosome_Homo sapiens_hsa030401.55042863
24RNA polymerase_Homo sapiens_hsa030201.54897726
25Autoimmune thyroid disease_Homo sapiens_hsa053201.52362523
26Nucleotide excision repair_Homo sapiens_hsa034201.50287293
27Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.49704039
28* Shigellosis_Homo sapiens_hsa051311.48351149
29NOD-like receptor signaling pathway_Homo sapiens_hsa046211.43540893
30Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.40548815
31p53 signaling pathway_Homo sapiens_hsa041151.38901877
32Pertussis_Homo sapiens_hsa051331.37238671
33Hematopoietic cell lineage_Homo sapiens_hsa046401.36925643
34Cell cycle_Homo sapiens_hsa041101.35963747
35Biosynthesis of amino acids_Homo sapiens_hsa012301.33583893
36Pyrimidine metabolism_Homo sapiens_hsa002401.33233588
37* Influenza A_Homo sapiens_hsa051641.32594372
38Epstein-Barr virus infection_Homo sapiens_hsa051691.30971033
39Osteoclast differentiation_Homo sapiens_hsa043801.29066184
40* Apoptosis_Homo sapiens_hsa042101.27852795
41Asthma_Homo sapiens_hsa053101.24612063
42* Viral myocarditis_Homo sapiens_hsa054161.24402253
43Malaria_Homo sapiens_hsa051441.23182811
44Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.21717641
45Jak-STAT signaling pathway_Homo sapiens_hsa046301.19809964
46Type I diabetes mellitus_Homo sapiens_hsa049401.19541642
47Toxoplasmosis_Homo sapiens_hsa051451.17186955
482-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.16520031
49Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.16065803
50TNF signaling pathway_Homo sapiens_hsa046681.15233120
51B cell receptor signaling pathway_Homo sapiens_hsa046621.13450726
52Hepatitis B_Homo sapiens_hsa051611.12288771
53One carbon pool by folate_Homo sapiens_hsa006701.11337888
54Tuberculosis_Homo sapiens_hsa051521.10341355
55* Salmonella infection_Homo sapiens_hsa051321.09313652
56Non-homologous end-joining_Homo sapiens_hsa034501.06324109
57Fanconi anemia pathway_Homo sapiens_hsa034601.05357654
58RNA transport_Homo sapiens_hsa030131.04924976
59Viral carcinogenesis_Homo sapiens_hsa052031.03463668
60T cell receptor signaling pathway_Homo sapiens_hsa046601.03269537
61RNA degradation_Homo sapiens_hsa030181.01724081
62* Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.00839525
63Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.97696067
64Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.92727075
65Systemic lupus erythematosus_Homo sapiens_hsa053220.91575788
66Rheumatoid arthritis_Homo sapiens_hsa053230.91322776
67HTLV-I infection_Homo sapiens_hsa051660.90865676
68Chemokine signaling pathway_Homo sapiens_hsa040620.90078810
69Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.89854752
70Endocytosis_Homo sapiens_hsa041440.88960478
71Carbon metabolism_Homo sapiens_hsa012000.88764660
72Galactose metabolism_Homo sapiens_hsa000520.87883026
73Protein export_Homo sapiens_hsa030600.86106525
74Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.83779519
75* Leukocyte transendothelial migration_Homo sapiens_hsa046700.81772873
76Transcriptional misregulation in cancer_Homo sapiens_hsa052020.81214543
77Central carbon metabolism in cancer_Homo sapiens_hsa052300.80600990
78Basal transcription factors_Homo sapiens_hsa030220.79266086
79Acute myeloid leukemia_Homo sapiens_hsa052210.75111751
80Fatty acid elongation_Homo sapiens_hsa000620.73522022
81* Vibrio cholerae infection_Homo sapiens_hsa051100.71885834
82Small cell lung cancer_Homo sapiens_hsa052220.70417237
83Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.69871854
84African trypanosomiasis_Homo sapiens_hsa051430.69722719
85Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.69358006
86* Phagosome_Homo sapiens_hsa041450.69098867
87Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.68701668
88Other glycan degradation_Homo sapiens_hsa005110.67975837
89SNARE interactions in vesicular transport_Homo sapiens_hsa041300.67845913
90AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.67409531
91Chronic myeloid leukemia_Homo sapiens_hsa052200.61986033
92Hepatitis C_Homo sapiens_hsa051600.61542841
93Staphylococcus aureus infection_Homo sapiens_hsa051500.59994102
94Fructose and mannose metabolism_Homo sapiens_hsa000510.58890359
95MicroRNAs in cancer_Homo sapiens_hsa052060.57648714
96Purine metabolism_Homo sapiens_hsa002300.55201841
97Alcoholism_Homo sapiens_hsa050340.54442171
98Bladder cancer_Homo sapiens_hsa052190.53653145
99Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.53311085
100Pancreatic cancer_Homo sapiens_hsa052120.53096218
101Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.52546929
102Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.52470889
103Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.51956672
104Non-small cell lung cancer_Homo sapiens_hsa052230.48016392
105Steroid biosynthesis_Homo sapiens_hsa001000.47594884
106Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.45028994
107Thyroid cancer_Homo sapiens_hsa052160.44880696
108* Platelet activation_Homo sapiens_hsa046110.44754057
109Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.43478537
110Lysosome_Homo sapiens_hsa041420.40730850
111N-Glycan biosynthesis_Homo sapiens_hsa005100.39493123
112Sphingolipid signaling pathway_Homo sapiens_hsa040710.37537925
113Colorectal cancer_Homo sapiens_hsa052100.37269131
114Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.37180670
115HIF-1 signaling pathway_Homo sapiens_hsa040660.36994894
116Notch signaling pathway_Homo sapiens_hsa043300.36873173
117* Regulation of actin cytoskeleton_Homo sapiens_hsa048100.35896014
118Neurotrophin signaling pathway_Homo sapiens_hsa047220.35848396
119Prolactin signaling pathway_Homo sapiens_hsa049170.34299382
120mRNA surveillance pathway_Homo sapiens_hsa030150.33715057
121Pathways in cancer_Homo sapiens_hsa052000.32944910
122Glycosaminoglycan degradation_Homo sapiens_hsa005310.30722550
123* Adherens junction_Homo sapiens_hsa045200.30612745

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