ACTBP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.99300667
2regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450916.12351037
3cytidine metabolic process (GO:0046087)5.38261277
4cytidine catabolic process (GO:0006216)5.38261277
5cytidine deamination (GO:0009972)5.38261277
6pyrimidine ribonucleoside catabolic process (GO:0046133)4.68290909
7Arp2/3 complex-mediated actin nucleation (GO:0034314)4.44566581
8positive regulation of T cell mediated cytotoxicity (GO:0001916)4.08906883
9cellular response to interleukin-15 (GO:0071350)4.07195593
10actin nucleation (GO:0045010)3.95296325
11protein deneddylation (GO:0000338)3.90575526
12positive regulation of defense response to virus by host (GO:0002230)3.66065506
13regulation of T cell mediated cytotoxicity (GO:0001914)3.60666410
14protein neddylation (GO:0045116)3.51836143
15platelet dense granule organization (GO:0060155)3.50611916
16positive regulation of interleukin-17 production (GO:0032740)3.50543909
17proteasome assembly (GO:0043248)3.44899295
18ATP synthesis coupled proton transport (GO:0015986)3.41811884
19energy coupled proton transport, down electrochemical gradient (GO:0015985)3.41811884
20positive regulation of alpha-beta T cell proliferation (GO:0046641)3.38336545
21antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.37560472
22response to interleukin-15 (GO:0070672)3.36309883
23regulation of B cell receptor signaling pathway (GO:0050855)3.36171039
24response to interferon-beta (GO:0035456)3.34658761
25mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.33236947
26regulation of cellular amino acid metabolic process (GO:0006521)3.32483311
27regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.26894809
28positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.25844622
29regulation of activation of Janus kinase activity (GO:0010533)3.22837648
30cullin deneddylation (GO:0010388)3.22033669
31positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.20483873
32negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.14991940
33antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.14871339
34DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.13673672
35immunoglobulin mediated immune response (GO:0016064)3.12457170
36nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.10392134
37positive regulation of T cell mediated immunity (GO:0002711)3.06596033
38signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.04198588
39signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.04198588
40signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.04198588
41metallo-sulfur cluster assembly (GO:0031163)3.04184182
42iron-sulfur cluster assembly (GO:0016226)3.04184182
43antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.03884680
44regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.03143070
45signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.02206263
46intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.02206263
47regulation of leukocyte mediated cytotoxicity (GO:0001910)3.01902706
48regulation of defense response to virus by host (GO:0050691)3.01645768
49positive regulation of cell killing (GO:0031343)3.00762711
50tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.00184940
51RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.00184940
52exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.99523982
53mast cell activation (GO:0045576)2.96594124
54negative regulation of T cell apoptotic process (GO:0070233)2.94522268
55regulation of alpha-beta T cell proliferation (GO:0046640)2.94079630
56establishment of protein localization to mitochondrial membrane (GO:0090151)2.93968704
57positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.93923328
58positive regulation of T-helper 1 type immune response (GO:0002827)2.93174393
59B cell mediated immunity (GO:0019724)2.91951147
60regulation of memory T cell differentiation (GO:0043380)2.91075118
61regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.90672089
62sequestering of actin monomers (GO:0042989)2.90073381
63mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.88416863
64RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.88350357
65signal transduction involved in DNA integrity checkpoint (GO:0072401)2.87260627
66signal transduction involved in DNA damage checkpoint (GO:0072422)2.87260627
67mannosylation (GO:0097502)2.84599188
68signal transduction involved in cell cycle checkpoint (GO:0072395)2.84485492
69negative T cell selection (GO:0043383)2.82890734
70protein-cofactor linkage (GO:0018065)2.82873055
71antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.80008793
72chaperone mediated protein folding requiring cofactor (GO:0051085)2.79827418
73regulation of cell killing (GO:0031341)2.79751809
74T cell migration (GO:0072678)2.78308541
75positive thymic T cell selection (GO:0045059)2.77405403
76regulation of regulatory T cell differentiation (GO:0045589)2.75908109
77negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.74565802
78negative regulation of ligase activity (GO:0051352)2.74565802
79regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.72117347
80regulation of isotype switching to IgG isotypes (GO:0048302)2.71285546
81adenosine metabolic process (GO:0046085)2.69842487
82regulation of immunoglobulin secretion (GO:0051023)2.68736536
83positive regulation of adaptive immune response based on somatic recombination of immune receptors b2.68375425
84negative regulation of lymphocyte apoptotic process (GO:0070229)2.68319374
85respiratory electron transport chain (GO:0022904)2.67981813
86electron transport chain (GO:0022900)2.67637852
87negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.67339640
88mast cell activation involved in immune response (GO:0002279)2.66770006
89mast cell degranulation (GO:0043303)2.66770006
90T cell receptor signaling pathway (GO:0050852)2.66500161
91T cell costimulation (GO:0031295)2.66363125
92lymphocyte costimulation (GO:0031294)2.62886845
93positive regulation of adaptive immune response (GO:0002821)2.60970263
94negative regulation of mast cell activation (GO:0033004)2.58287335
95negative thymic T cell selection (GO:0045060)2.57251175
96negative regulation of viral genome replication (GO:0045071)2.56639218
97anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.54124341
98pyrimidine nucleoside catabolic process (GO:0046135)2.53778527
99positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.53104930
100positive regulation of lymphocyte mediated immunity (GO:0002708)2.49813535

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.10496008
2NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.65623351
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.64299494
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.54524644
5ELF1_17652178_ChIP-ChIP_JURKAT_Human3.48083237
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.27842732
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.21345982
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.18820346
9IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.03233288
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.89988298
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.78478462
12VDR_23849224_ChIP-Seq_CD4+_Human2.71079637
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.55256739
14E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.45176632
15VDR_22108803_ChIP-Seq_LS180_Human2.44044818
16IRF8_21731497_ChIP-ChIP_J774_Mouse2.43692295
17FLI1_27457419_Chip-Seq_LIVER_Mouse2.36688568
18STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.31242554
19SRF_21415370_ChIP-Seq_HL-1_Mouse2.28458972
20FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.27846420
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.09215655
22ETS1_20019798_ChIP-Seq_JURKAT_Human2.08188281
23SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.08041562
24MYB_26560356_Chip-Seq_TH2_Human2.04211424
25CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.00586931
26BP1_19119308_ChIP-ChIP_Hs578T_Human2.00426132
27IRF1_19129219_ChIP-ChIP_H3396_Human1.97104525
28SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.95845278
29EGR1_23403033_ChIP-Seq_LIVER_Mouse1.95171391
30STAT4_19710469_ChIP-ChIP_TH1__Mouse1.94648122
31ELK1_19687146_ChIP-ChIP_HELA_Human1.93541788
32ZNF274_21170338_ChIP-Seq_K562_Hela1.91317180
33PCGF2_27294783_Chip-Seq_ESCs_Mouse1.90130065
34FOXP3_21729870_ChIP-Seq_TREG_Human1.87978888
35NOTCH1_21737748_ChIP-Seq_TLL_Human1.86077629
36FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.80277239
37GATA3_26560356_Chip-Seq_TH2_Human1.78610766
38PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.72743226
39CREB1_15753290_ChIP-ChIP_HEK293T_Human1.66089991
40RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.65354708
41HOXB4_20404135_ChIP-ChIP_EML_Mouse1.64665150
42LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.60728739
43SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.56517435
44E2F4_17652178_ChIP-ChIP_JURKAT_Human1.54153035
45MYC_18940864_ChIP-ChIP_HL60_Human1.53474008
46RUNX_20019798_ChIP-Seq_JUKART_Human1.51530934
47GATA3_27048872_Chip-Seq_THYMUS_Human1.42946180
48CIITA_25753668_ChIP-Seq_RAJI_Human1.36548567
49YY1_21170310_ChIP-Seq_MESCs_Mouse1.35832297
50PCGF2_27294783_Chip-Seq_NPCs_Mouse1.35142782
51PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.31807527
52NFE2_27457419_Chip-Seq_LIVER_Mouse1.22991461
53FOXA1_25329375_ChIP-Seq_VCAP_Human1.20358972
54FOXA1_27270436_Chip-Seq_PROSTATE_Human1.20358972
55MYB_26560356_Chip-Seq_TH1_Human1.19935961
56MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.19929502
57DCP1A_22483619_ChIP-Seq_HELA_Human1.19922539
58SUZ12_27294783_Chip-Seq_NPCs_Mouse1.19570451
59TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.19114906
60AR_20517297_ChIP-Seq_VCAP_Human1.18780526
61SPI1_23547873_ChIP-Seq_NB4_Human1.18766540
62PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.18241319
63EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.17899385
64IGF1R_20145208_ChIP-Seq_DFB_Human1.17660069
65LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.14872124
66FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14379211
67MYC_18358816_ChIP-ChIP_MESCs_Mouse1.13595137
68CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.12367157
69EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.12325080
70PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11618751
71FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.11077468
72TP53_22573176_ChIP-Seq_HFKS_Human1.09415426
73PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.08264729
74CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.08106973
75PADI4_21655091_ChIP-ChIP_MCF-7_Human1.06742697
76ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.05511600
77EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.04673778
78GABP_19822575_ChIP-Seq_HepG2_Human1.03039237
79E2F1_18555785_ChIP-Seq_MESCs_Mouse1.01935084
80TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.01785425
81CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.01151099
82RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.00654496
83SOX2_19829295_ChIP-Seq_ESCs_Human1.00114347
84NANOG_19829295_ChIP-Seq_ESCs_Human1.00114347
85EWS_26573619_Chip-Seq_HEK293_Human0.97133639
86NANOG_20526341_ChIP-Seq_ESCs_Human0.96673065
87MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.95523789
88EZH2_27294783_Chip-Seq_NPCs_Mouse0.95291099
89GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.95092642
90NCOR_22424771_ChIP-Seq_293T_Human0.94053490
91AUTS2_25519132_ChIP-Seq_293T-REX_Human0.91883609
92ERG_20517297_ChIP-Seq_VCAP_Human0.91319256
93RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.90112975
94STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.87579303
95GATA3_26560356_Chip-Seq_TH1_Human0.87291494
96FOXA1_21572438_ChIP-Seq_LNCaP_Human0.86690400
97THAP11_20581084_ChIP-Seq_MESCs_Mouse0.86670595
98MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.86579826
99GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85803591
100POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.85365247

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to5.48057924
2MP0001835_abnormal_antigen_presentation4.04866687
3MP0009785_altered_susceptibility_to2.95916025
4MP0005000_abnormal_immune_tolerance2.73286174
5MP0000685_abnormal_immune_system2.71586899
6MP0003724_increased_susceptibility_to2.71240626
7MP0001800_abnormal_humoral_immune2.56142557
8MP0003763_abnormal_thymus_physiology2.53844705
9MP0001790_abnormal_immune_system2.46459144
10MP0005387_immune_system_phenotype2.46459144
11MP0002166_altered_tumor_susceptibility2.40124752
12MP0002138_abnormal_hepatobiliary_system2.38463875
13MP0005645_abnormal_hypothalamus_physiol2.36804846
14MP0002148_abnormal_hypersensitivity_rea2.23318084
15MP0002723_abnormal_immune_serum2.19452962
16MP0000372_irregular_coat_pigmentation2.13787038
17MP0004147_increased_porphyrin_level2.10602723
18MP0003195_calcinosis2.05877517
19MP0003436_decreased_susceptibility_to2.04284550
20MP0002420_abnormal_adaptive_immunity2.00900576
21MP0002102_abnormal_ear_morphology1.99950030
22MP0002452_abnormal_antigen_presenting1.99337946
23MP0001819_abnormal_immune_cell1.99087643
24MP0002006_tumorigenesis1.98191169
25MP0005025_abnormal_response_to1.94517475
26MP0005084_abnormal_gallbladder_morpholo1.80862547
27MP0001529_abnormal_vocalization1.76584326
28MP0005075_abnormal_melanosome_morpholog1.76045818
29MP0009333_abnormal_splenocyte_physiolog1.75000591
30MP0003866_abnormal_defecation1.65535866
31MP0008875_abnormal_xenobiotic_pharmacok1.63394802
32MP0000465_gastrointestinal_hemorrhage1.62104327
33MP0008872_abnormal_physiological_respon1.59415763
34MP0002933_joint_inflammation1.57804392
35MP0005464_abnormal_platelet_physiology1.56144820
36MP0010155_abnormal_intestine_physiology1.53013217
37MP0003806_abnormal_nucleotide_metabolis1.49262738
38MP0000716_abnormal_immune_system1.48063468
39MP0002398_abnormal_bone_marrow1.47842807
40MP0006072_abnormal_retinal_apoptosis1.46364871
41MP0000689_abnormal_spleen_morphology1.42354050
42MP0006036_abnormal_mitochondrial_physio1.41676432
43MP0001845_abnormal_inflammatory_respons1.41086250
44MP0002419_abnormal_innate_immunity1.36922872
45MP0002876_abnormal_thyroid_physiology1.33982418
46MP0003786_premature_aging1.33329922
47MP0002736_abnormal_nociception_after1.32928589
48MP0001853_heart_inflammation1.31734460
49MP0001986_abnormal_taste_sensitivity1.30231933
50MP0002722_abnormal_immune_system1.26899141
51MP0009764_decreased_sensitivity_to1.25905616
52MP0001764_abnormal_homeostasis1.25452629
53MP0003011_delayed_dark_adaptation1.21276191
54MP0002429_abnormal_blood_cell1.20272047
55MP0005167_abnormal_blood-brain_barrier1.18305965
56MP0001919_abnormal_reproductive_system1.18285769
57MP0000703_abnormal_thymus_morphology1.17485687
58MP0001533_abnormal_skeleton_physiology1.16462405
59MP0002405_respiratory_system_inflammati1.13231921
60MP0005646_abnormal_pituitary_gland1.12206202
61MP0001968_abnormal_touch/_nociception1.11866918
62MP0001905_abnormal_dopamine_level1.09564763
63MP0006035_abnormal_mitochondrial_morpho1.08706196
64MP0005253_abnormal_eye_physiology1.08305198
65MP0008877_abnormal_DNA_methylation1.02860948
66MP0003638_abnormal_response/metabolism_1.00683695
67MP0008058_abnormal_DNA_repair0.95600835
68MP0005551_abnormal_eye_electrophysiolog0.92771512
69MP0008995_early_reproductive_senescence0.91605086
70MP0002822_catalepsy0.91598560
71MP0008469_abnormal_protein_level0.89978922
72MP0003880_abnormal_central_pattern0.89290535
73MP0006054_spinal_hemorrhage0.85486109
74MP0002653_abnormal_ependyma_morphology0.85033412
75MP0009763_increased_sensitivity_to0.84356513
76MP0004145_abnormal_muscle_electrophysio0.84119823
77MP0001873_stomach_inflammation0.82801247
78MP0002837_dystrophic_cardiac_calcinosis0.82172277
79MP0003693_abnormal_embryo_hatching0.80795929
80MP0003646_muscle_fatigue0.76524786
81MP0005389_reproductive_system_phenotype0.75676006
82MP0005410_abnormal_fertilization0.75355502
83MP0005332_abnormal_amino_acid0.75218345
84MP0005085_abnormal_gallbladder_physiolo0.75215328
85MP0005360_urolithiasis0.74042407
86MP0004142_abnormal_muscle_tone0.73464209
87MP0004947_skin_inflammation0.72505281
88MP0009697_abnormal_copulation0.71084463
89MP0001765_abnormal_ion_homeostasis0.70238018
90MP0003448_altered_tumor_morphology0.70229113
91MP0005636_abnormal_mineral_homeostasis0.69610422
92MP0005377_hearing/vestibular/ear_phenot0.69567153
93MP0003878_abnormal_ear_physiology0.69567153
94MP0002019_abnormal_tumor_incidence0.69448805
95MP0002095_abnormal_skin_pigmentation0.65437378
96MP0002272_abnormal_nervous_system0.63629449
97MP0009643_abnormal_urine_homeostasis0.62866640
98MP0002277_abnormal_respiratory_mucosa0.62136968
99MP0003252_abnormal_bile_duct0.59585180
100MP0003045_fibrosis0.59217969

Predicted human phenotypes

RankGene SetZ-score
1IgG deficiency (HP:0004315)4.95978111
2Elevated erythrocyte sedimentation rate (HP:0003565)4.44810594
3Hepatocellular necrosis (HP:0001404)3.74138495
4Mitochondrial inheritance (HP:0001427)3.68466363
5Stomatitis (HP:0010280)3.56918011
6Hepatic necrosis (HP:0002605)3.44605302
7Acute necrotizing encephalopathy (HP:0006965)3.38271854
8Increased CSF lactate (HP:0002490)3.35647138
9Severe combined immunodeficiency (HP:0004430)3.23163597
10Abnormal mitochondria in muscle tissue (HP:0008316)3.19564497
11Chronic mucocutaneous candidiasis (HP:0002728)3.17456722
12Recurrent cutaneous fungal infections (HP:0011370)3.17456722
13Increased IgM level (HP:0003496)3.10808644
14T lymphocytopenia (HP:0005403)3.08259942
15Renal Fanconi syndrome (HP:0001994)3.07270569
16Panhypogammaglobulinemia (HP:0003139)3.05509571
17Acute encephalopathy (HP:0006846)3.03928219
18Abnormality of T cells (HP:0002843)2.97963891
19Increased hepatocellular lipid droplets (HP:0006565)2.94413520
20Hypoproteinemia (HP:0003075)2.92717402
213-Methylglutaconic aciduria (HP:0003535)2.92639236
22Abnormality of the prostate (HP:0008775)2.88294700
23Abnormality of T cell number (HP:0011839)2.83919506
24Encephalitis (HP:0002383)2.83036274
25Lipid accumulation in hepatocytes (HP:0006561)2.76017303
26Optic neuritis (HP:0100653)2.73962229
27Retrobulbar optic neuritis (HP:0100654)2.73962229
28Progressive macrocephaly (HP:0004481)2.71334528
29Abnormality of T cell physiology (HP:0011840)2.70423704
30Increased serum lactate (HP:0002151)2.68552677
31Type I transferrin isoform profile (HP:0003642)2.65275378
32Cerebral edema (HP:0002181)2.61085768
33Exertional dyspnea (HP:0002875)2.58747979
34Aplastic anemia (HP:0001915)2.58558937
35Myositis (HP:0100614)2.57872308
36Prostate neoplasm (HP:0100787)2.57029896
37Combined immunodeficiency (HP:0005387)2.49672487
38Decreased electroretinogram (ERG) amplitude (HP:0000654)2.49223301
39Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.48127351
40Agammaglobulinemia (HP:0004432)2.47473640
41Lactic acidosis (HP:0003128)2.45368880
42Abolished electroretinogram (ERG) (HP:0000550)2.43148365
43Generalized aminoaciduria (HP:0002909)2.38351681
44Congenital stationary night blindness (HP:0007642)2.37772000
45Abnormality of eosinophils (HP:0001879)2.37488690
46Recurrent bronchitis (HP:0002837)2.36219287
47Abnormal protein glycosylation (HP:0012346)2.31750142
48Abnormal glycosylation (HP:0012345)2.31750142
49Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.31750142
50Abnormal protein N-linked glycosylation (HP:0012347)2.31750142
51Increased intramyocellular lipid droplets (HP:0012240)2.28918457
52Abnormal delayed hypersensitivity skin test (HP:0002963)2.28369025
53IgM deficiency (HP:0002850)2.25007983
54Renal cortical cysts (HP:0000803)2.19986146
55Conical tooth (HP:0000698)2.16736270
56Orchitis (HP:0100796)2.15566677
57Chronic diarrhea (HP:0002028)2.13989437
58Thyroiditis (HP:0100646)2.10159823
59Recurrent fungal infections (HP:0002841)2.07287722
60Optic disc pallor (HP:0000543)2.06083280
61Congenital, generalized hypertrichosis (HP:0004540)2.05541127
62Lymphopenia (HP:0001888)2.03965567
63Meningitis (HP:0001287)2.02836267
64Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.98170486
65Aplasia/hypoplasia of the uterus (HP:0008684)1.97168836
66Hypoplasia of the uterus (HP:0000013)1.96839576
67Abnormality of aspartate family amino acid metabolism (HP:0010899)1.95585963
68Petechiae (HP:0000967)1.95115743
69Keratoconjunctivitis (HP:0001096)1.95083996
70Respiratory failure (HP:0002878)1.93479640
71Increased muscle lipid content (HP:0009058)1.91179216
72Vasculitis (HP:0002633)1.91094635
73Hypothermia (HP:0002045)1.89339024
74Decreased central vision (HP:0007663)1.88430289
75Pulmonary infiltrates (HP:0002113)1.85941354
76IgA deficiency (HP:0002720)1.85760671
77Abnormality of B cell number (HP:0010975)1.84980167
78Abnormality of urine glucose concentration (HP:0011016)1.84585265
79Glycosuria (HP:0003076)1.84585265
80Keratoconjunctivitis sicca (HP:0001097)1.82806260
81Pulmonary fibrosis (HP:0002206)1.82634515
82Pancytopenia (HP:0001876)1.82549703
83Opisthotonus (HP:0002179)1.82311199
84Neutropenia (HP:0001875)1.80882317
85Lethargy (HP:0001254)1.80665323
86Dry hair (HP:0011359)1.80539925
87Thyroid-stimulating hormone excess (HP:0002925)1.79647233
88Stomach cancer (HP:0012126)1.77959917
89Abnormality of cells of the lymphoid lineage (HP:0012140)1.77932796
90Leukocytosis (HP:0001974)1.77616484
91B lymphocytopenia (HP:0010976)1.76931618
92Dicarboxylic aciduria (HP:0003215)1.76654733
93Abnormality of dicarboxylic acid metabolism (HP:0010995)1.76654733
94Eosinophilia (HP:0001880)1.75730832
95Pancreatitis (HP:0001733)1.75432865
96Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.74642524
97Attenuation of retinal blood vessels (HP:0007843)1.74145040
98Cerebral palsy (HP:0100021)1.73817112
99Exercise intolerance (HP:0003546)1.73383574
100Pancreatic cysts (HP:0001737)1.73096461

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK34.41602593
2TLK14.05498917
3TXK3.71043673
4ZAK3.50244407
5BCKDK3.24489454
6MAP4K23.21622894
7VRK22.92102452
8KDR2.80402598
9VRK12.76180352
10TESK22.61722578
11MST42.42854427
12NUAK12.16349947
13MAP4K11.89767998
14GRK61.71713374
15TEC1.54676545
16NEK11.53858586
17MAP3K121.53140787
18IKBKB1.52126818
19TIE11.41259850
20ADRBK21.37194432
21GRK11.32661410
22TRIM281.30639662
23BUB11.27912967
24TESK11.26962171
25SYK1.26616453
26DAPK11.24879049
27MAP3K141.16695351
28BTK1.14660458
29IKBKE1.13861837
30KIT1.13819927
31MYLK1.11283537
32LIMK11.07657767
33CSNK1G31.03237376
34TBK11.01307761
35ITK1.01127979
36MAPKAPK30.98321662
37PRKCQ0.96532665
38OXSR10.94287918
39RPS6KA50.93997044
40CDK190.93775209
41SIK30.93623840
42BMPR20.92842175
43EIF2AK30.88156985
44LYN0.88079443
45DAPK30.87404511
46LCK0.86093758
47FES0.85480551
48TNK20.85297698
49CSNK1A1L0.84578404
50CSF1R0.82566217
51CSNK1G20.75926688
52CCNB10.75752014
53TSSK60.74926172
54ERBB30.74023799
55SRPK10.72133400
56EIF2AK20.71904003
57MAP2K20.71635858
58JAK30.71393576
59WNK30.71203854
60DYRK20.69889749
61CSNK1G10.68313431
62MATK0.68010450
63BCR0.67475424
64TAF10.64125028
65IGF1R0.61818506
66PDK20.58303941
67ZAP700.57520538
68PINK10.57214961
69INSRR0.55086091
70PLK30.54726930
71EPHA30.53933368
72AURKA0.52462494
73CSK0.52296542
74WNK40.51215421
75JAK10.51162853
76EIF2AK10.50831499
77MAPK130.50811839
78MAPKAPK50.47916780
79PHKG10.44850510
80PHKG20.44850510
81GRK50.44529739
82AURKB0.43292438
83PTK2B0.41703539
84MUSK0.41535890
85STK390.39996421
86PIM10.39030973
87HCK0.38948818
88ABL10.38406235
89MAP3K110.36433722
90ILK0.34486450
91PIM20.34038809
92MARK30.31810981
93PLK40.29377370
94RIPK40.29004147
95ADRBK10.28904056
96PRKCD0.27241038
97PAK10.26612177
98INSR0.25988766
99PKN10.25933542
100ATR0.25917942

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.95368085
2Primary immunodeficiency_Homo sapiens_hsa053403.72945350
3Asthma_Homo sapiens_hsa053103.34221239
4Graft-versus-host disease_Homo sapiens_hsa053323.31011208
5Allograft rejection_Homo sapiens_hsa053303.30961805
6Intestinal immune network for IgA production_Homo sapiens_hsa046723.18250840
7Autoimmune thyroid disease_Homo sapiens_hsa053203.17835225
8Oxidative phosphorylation_Homo sapiens_hsa001902.59355529
9Systemic lupus erythematosus_Homo sapiens_hsa053222.52546151
10Type I diabetes mellitus_Homo sapiens_hsa049402.50542723
11Antigen processing and presentation_Homo sapiens_hsa046122.43342669
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.27321177
13Parkinsons disease_Homo sapiens_hsa050122.24800135
14Protein export_Homo sapiens_hsa030601.70191886
15Viral myocarditis_Homo sapiens_hsa054161.68311752
16Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.63510408
17RNA polymerase_Homo sapiens_hsa030201.55798842
18Rheumatoid arthritis_Homo sapiens_hsa053231.53555501
19Hematopoietic cell lineage_Homo sapiens_hsa046401.50499331
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.42150234
21Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.33476891
22Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.28230692
23Fatty acid elongation_Homo sapiens_hsa000621.21810729
24Huntingtons disease_Homo sapiens_hsa050161.20957809
25Alzheimers disease_Homo sapiens_hsa050101.20261058
26Propanoate metabolism_Homo sapiens_hsa006401.16847254
27RNA degradation_Homo sapiens_hsa030181.10688076
28Nitrogen metabolism_Homo sapiens_hsa009101.08470115
29Alcoholism_Homo sapiens_hsa050341.07908945
30Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.05728110
31Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.03798209
32T cell receptor signaling pathway_Homo sapiens_hsa046601.03395611
33Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.01479722
34Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.01442919
35Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.99102400
36Shigellosis_Homo sapiens_hsa051310.93594808
37Tryptophan metabolism_Homo sapiens_hsa003800.92436570
38Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.90285468
39Caffeine metabolism_Homo sapiens_hsa002320.89904938
40Sulfur metabolism_Homo sapiens_hsa009200.89367727
41Phototransduction_Homo sapiens_hsa047440.87160735
42Peroxisome_Homo sapiens_hsa041460.86384375
43Staphylococcus aureus infection_Homo sapiens_hsa051500.84734642
44One carbon pool by folate_Homo sapiens_hsa006700.83440025
45Leishmaniasis_Homo sapiens_hsa051400.82363457
46alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.81345940
47Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.80537405
48Collecting duct acid secretion_Homo sapiens_hsa049660.80400009
49Basal transcription factors_Homo sapiens_hsa030220.79768013
50Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.77449040
51Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.77357682
52NF-kappa B signaling pathway_Homo sapiens_hsa040640.77005182
53Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.76787102
54Pyrimidine metabolism_Homo sapiens_hsa002400.76575402
55Nucleotide excision repair_Homo sapiens_hsa034200.73582198
56Spliceosome_Homo sapiens_hsa030400.73096701
57Butanoate metabolism_Homo sapiens_hsa006500.71926614
58DNA replication_Homo sapiens_hsa030300.70932772
59Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.70702072
60Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.69082568
61Purine metabolism_Homo sapiens_hsa002300.67189458
62Mismatch repair_Homo sapiens_hsa034300.66403334
63Herpes simplex infection_Homo sapiens_hsa051680.66168141
64Homologous recombination_Homo sapiens_hsa034400.65012429
65Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.64761960
66Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.63576174
672-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.63093052
68Linoleic acid metabolism_Homo sapiens_hsa005910.62597936
69SNARE interactions in vesicular transport_Homo sapiens_hsa041300.62511911
70Measles_Homo sapiens_hsa051620.60172715
71Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.58867223
72Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.58753399
73Epstein-Barr virus infection_Homo sapiens_hsa051690.57858703
74Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.57013859
75Regulation of autophagy_Homo sapiens_hsa041400.56898641
76Cardiac muscle contraction_Homo sapiens_hsa042600.56879600
77Chemical carcinogenesis_Homo sapiens_hsa052040.55580379
78Fanconi anemia pathway_Homo sapiens_hsa034600.54404284
79Sulfur relay system_Homo sapiens_hsa041220.54022164
80Cysteine and methionine metabolism_Homo sapiens_hsa002700.53988921
81NOD-like receptor signaling pathway_Homo sapiens_hsa046210.51780484
82Ribosome_Homo sapiens_hsa030100.49648356
83Fatty acid degradation_Homo sapiens_hsa000710.46916837
84Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.46370299
85Primary bile acid biosynthesis_Homo sapiens_hsa001200.45999776
86Phagosome_Homo sapiens_hsa041450.45822791
87Base excision repair_Homo sapiens_hsa034100.44328625
88Legionellosis_Homo sapiens_hsa051340.43059968
89Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.42816317
90Metabolic pathways_Homo sapiens_hsa011000.41517922
91Biosynthesis of amino acids_Homo sapiens_hsa012300.39724974
92Jak-STAT signaling pathway_Homo sapiens_hsa046300.39461998
93Retinol metabolism_Homo sapiens_hsa008300.38714988
94Arachidonic acid metabolism_Homo sapiens_hsa005900.38639919
95Glutathione metabolism_Homo sapiens_hsa004800.38638510
96Steroid hormone biosynthesis_Homo sapiens_hsa001400.38555618
97Malaria_Homo sapiens_hsa051440.37641567
98Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.36994013
99Carbon metabolism_Homo sapiens_hsa012000.36570710
100Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.35872112

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