ACTBP14

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.52094809
2Arp2/3 complex-mediated actin nucleation (GO:0034314)4.80533696
3actin nucleation (GO:0045010)4.37586985
4regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.33710221
5cytidine metabolic process (GO:0046087)4.25545551
6cytidine catabolic process (GO:0006216)4.25545551
7cytidine deamination (GO:0009972)4.25545551
8pyrimidine ribonucleoside catabolic process (GO:0046133)3.74296671
9ATP synthesis coupled proton transport (GO:0015986)3.68762527
10energy coupled proton transport, down electrochemical gradient (GO:0015985)3.68762527
11platelet dense granule organization (GO:0060155)3.62579110
12mast cell activation (GO:0045576)3.53067723
13negative T cell selection (GO:0043383)3.51115701
14mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.44691461
15immunoglobulin mediated immune response (GO:0016064)3.43266872
16protein deneddylation (GO:0000338)3.42361035
17antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.42261763
18positive regulation of interleukin-8 secretion (GO:2000484)3.42226827
19positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.36847988
20cellular response to interleukin-15 (GO:0071350)3.36750764
21positive regulation of gamma-delta T cell activation (GO:0046645)3.35777368
22negative regulation of T cell apoptotic process (GO:0070233)3.35055118
23positive regulation of defense response to virus by host (GO:0002230)3.33662622
24tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.31044313
25RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.31044313
26positive regulation of T cell mediated cytotoxicity (GO:0001916)3.30861285
27sequestering of actin monomers (GO:0042989)3.27578641
28regulation of interleukin-8 secretion (GO:2000482)3.25451220
29regulation of regulatory T cell differentiation (GO:0045589)3.21487461
30negative thymic T cell selection (GO:0045060)3.18885340
31iron-sulfur cluster assembly (GO:0016226)3.18192883
32metallo-sulfur cluster assembly (GO:0031163)3.18192883
33regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.18016943
34regulation of T cell receptor signaling pathway (GO:0050856)3.17398782
35preassembly of GPI anchor in ER membrane (GO:0016254)3.16537162
36B cell mediated immunity (GO:0019724)3.09626845
37positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.08896375
38regulation of isotype switching to IgG isotypes (GO:0048302)3.07000135
39positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.03287234
40regulation of gamma-delta T cell differentiation (GO:0045586)3.02399167
41response to interferon-beta (GO:0035456)3.01596049
42mature B cell differentiation involved in immune response (GO:0002313)3.01460869
43GPI anchor biosynthetic process (GO:0006506)3.01363424
44regulation of T cell mediated cytotoxicity (GO:0001914)3.01141427
45positive regulation of T cell cytokine production (GO:0002726)2.98958247
46T cell receptor signaling pathway (GO:0050852)2.98126130
47GPI anchor metabolic process (GO:0006505)2.96056775
48positive regulation of alpha-beta T cell proliferation (GO:0046641)2.93947026
49mast cell activation involved in immune response (GO:0002279)2.91186298
50mast cell degranulation (GO:0043303)2.91186298
51positive thymic T cell selection (GO:0045059)2.89089140
52regulation of leukocyte mediated cytotoxicity (GO:0001910)2.88468108
53regulation of hypersensitivity (GO:0002883)2.88462364
54regulation of germinal center formation (GO:0002634)2.88289821
55positive regulation of protein homodimerization activity (GO:0090073)2.87854786
56T cell costimulation (GO:0031295)2.85243607
57cullin deneddylation (GO:0010388)2.85151913
58lymphocyte costimulation (GO:0031294)2.84838491
59regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.83813037
60mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.81940789
61chaperone mediated protein folding requiring cofactor (GO:0051085)2.80299348
62regulation of B cell receptor signaling pathway (GO:0050855)2.79382926
63positive regulation of T cell mediated immunity (GO:0002711)2.78282951
64positive regulation of calcium-mediated signaling (GO:0050850)2.77494998
65positive T cell selection (GO:0043368)2.77293509
66regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.74751504
67positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.72396058
68L-fucose metabolic process (GO:0042354)2.72079791
69L-fucose catabolic process (GO:0042355)2.72079791
70fucose catabolic process (GO:0019317)2.72079791
71response to interleukin-15 (GO:0070672)2.71877443
72L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.71684001
73antigen receptor-mediated signaling pathway (GO:0050851)2.71172508
74tolerance induction (GO:0002507)2.69793807
75negative regulation of mast cell activation (GO:0033004)2.68830080
76negative regulation of heart rate (GO:0010459)2.68789518
77sleep (GO:0030431)2.68235002
78negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.67889837
79positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.65656983
80protein neddylation (GO:0045116)2.64573793
81negative regulation of lymphocyte apoptotic process (GO:0070229)2.64185418
82mannosylation (GO:0097502)2.63724425
83S-adenosylmethionine metabolic process (GO:0046500)2.63693109
84positive regulation of cell killing (GO:0031343)2.63115952
85positive regulation of adaptive immune response based on somatic recombination of immune receptors b2.61225953
86electron transport chain (GO:0022900)2.60576593
87purine deoxyribonucleotide catabolic process (GO:0009155)2.59783741
88positive regulation of adaptive immune response (GO:0002821)2.59430492
89respiratory electron transport chain (GO:0022904)2.58995353
90positive regulation of T-helper 1 type immune response (GO:0002827)2.58698810
91regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.58259817
92regulation of cellular amino acid metabolic process (GO:0006521)2.57249917
93regulation of defense response to virus by host (GO:0050691)2.56592149
94regulation of cell killing (GO:0031341)2.54315800
95negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.53367408
96RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.52977564
97regulation of gamma-delta T cell activation (GO:0046643)2.51368777
98positive regulation of natural killer cell mediated immunity (GO:0002717)2.50266565
99adenosine metabolic process (GO:0046085)2.49966458
100regulation of alpha-beta T cell proliferation (GO:0046640)2.49451958

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.40644122
2NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.44476200
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.34509474
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.16947529
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.14779175
6ELF1_17652178_ChIP-ChIP_JURKAT_Human3.06623011
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.05003775
8BP1_19119308_ChIP-ChIP_Hs578T_Human3.00071262
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.93399849
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.86317694
11CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.61711453
12FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.53404514
13IRF8_21731497_ChIP-ChIP_J774_Mouse2.49280108
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.48085542
15FLI1_27457419_Chip-Seq_LIVER_Mouse2.37447124
16VDR_23849224_ChIP-Seq_CD4+_Human2.36947104
17EST1_17652178_ChIP-ChIP_JURKAT_Human2.36536436
18HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.18029152
19MYB_26560356_Chip-Seq_TH2_Human2.15581435
20GATA3_26560356_Chip-Seq_TH2_Human2.10333070
21LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.07974151
22VDR_22108803_ChIP-Seq_LS180_Human2.06223777
23ZNF274_21170338_ChIP-Seq_K562_Hela1.94302204
24SRF_21415370_ChIP-Seq_HL-1_Mouse1.92633946
25PCGF2_27294783_Chip-Seq_ESCs_Mouse1.86188841
26FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.82212731
27RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.79721605
28IGF1R_20145208_ChIP-Seq_DFB_Human1.77113250
29RUNX_20019798_ChIP-Seq_JUKART_Human1.75377674
30SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.73347478
31ELK1_19687146_ChIP-ChIP_HELA_Human1.71996886
32NOTCH1_21737748_ChIP-Seq_TLL_Human1.70941683
33ETS1_20019798_ChIP-Seq_JURKAT_Human1.65372666
34FOXP3_21729870_ChIP-Seq_TREG_Human1.63531238
35GATA3_27048872_Chip-Seq_THYMUS_Human1.58588689
36PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.51167557
37FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.50187288
38STAT4_19710469_ChIP-ChIP_TH1__Mouse1.48854787
39AR_20517297_ChIP-Seq_VCAP_Human1.46943603
40E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.43903613
41MYC_18940864_ChIP-ChIP_HL60_Human1.43412930
42FOXA1_27270436_Chip-Seq_PROSTATE_Human1.40037569
43FOXA1_25329375_ChIP-Seq_VCAP_Human1.40037569
44CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.39084567
45GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36460742
46CIITA_25753668_ChIP-Seq_RAJI_Human1.36395072
47LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.35192646
48EGR1_23403033_ChIP-Seq_LIVER_Mouse1.34365857
49PCGF2_27294783_Chip-Seq_NPCs_Mouse1.34142255
50PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.31835483
51TAF15_26573619_Chip-Seq_HEK293_Human1.29270296
52PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.25537296
53EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.25335806
54SPI1_23547873_ChIP-Seq_NB4_Human1.23704084
55ZFP57_27257070_Chip-Seq_ESCs_Mouse1.23477895
56TP53_22573176_ChIP-Seq_HFKS_Human1.22698513
57CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.21226328
58SOX2_19829295_ChIP-Seq_ESCs_Human1.20689816
59NANOG_19829295_ChIP-Seq_ESCs_Human1.20689816
60SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.20430291
61RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.20056400
62FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17507145
63TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.16178849
64CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.14417679
65GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.14196369
66FOXA1_21572438_ChIP-Seq_LNCaP_Human1.13690749
67BCL6_27268052_Chip-Seq_Bcells_Human1.13168830
68EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.12149192
69CREB1_15753290_ChIP-ChIP_HEK293T_Human1.11476772
70MYB_26560356_Chip-Seq_TH1_Human1.11171636
71IRF1_19129219_ChIP-ChIP_H3396_Human1.10449421
72NFE2_27457419_Chip-Seq_LIVER_Mouse1.09226789
73ERA_21632823_ChIP-Seq_H3396_Human1.08993041
74AUTS2_25519132_ChIP-Seq_293T-REX_Human1.08781350
75SUZ12_27294783_Chip-Seq_NPCs_Mouse1.08538766
76NCOR_22424771_ChIP-Seq_293T_Human1.07587752
77GATA3_21878914_ChIP-Seq_MCF-7_Human1.06517092
78TAF2_19829295_ChIP-Seq_ESCs_Human1.05979999
79RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.05723282
80STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.04282616
81NANOG_20526341_ChIP-Seq_ESCs_Human1.04198206
82ER_23166858_ChIP-Seq_MCF-7_Human1.03156303
83IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.01126112
84CBP_20019798_ChIP-Seq_JUKART_Human1.01126112
85GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.01033837
86GATA3_26560356_Chip-Seq_TH1_Human1.00481283
87CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.00295656
88MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.99248755
89MYC_19829295_ChIP-Seq_ESCs_Human0.98779729
90FOXH1_21741376_ChIP-Seq_EPCs_Human0.98015928
91STAT1_20625510_ChIP-Seq_HELA_Human0.97659208
92GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.97460706
93MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.96885969
94EWS_26573619_Chip-Seq_HEK293_Human0.96593059
95EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.96433334
96CTBP1_25329375_ChIP-Seq_LNCAP_Human0.95403234
97ERG_20517297_ChIP-Seq_VCAP_Human0.95192076
98TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94947094
99P300_27268052_Chip-Seq_Bcells_Human0.92943096
100POU3F2_20337985_ChIP-ChIP_501MEL_Human0.92023774

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to5.11017279
2MP0003724_increased_susceptibility_to3.81231886
3MP0001835_abnormal_antigen_presentation3.60873622
4MP0009785_altered_susceptibility_to2.61788207
5MP0005000_abnormal_immune_tolerance2.61297518
6MP0001800_abnormal_humoral_immune2.57909853
7MP0002148_abnormal_hypersensitivity_rea2.57346850
8MP0000685_abnormal_immune_system2.44184695
9MP0006072_abnormal_retinal_apoptosis2.35867018
10MP0002723_abnormal_immune_serum2.19392630
11MP0002166_altered_tumor_susceptibility2.15576119
12MP0004147_increased_porphyrin_level2.09366456
13MP0002452_abnormal_antigen_presenting1.99301000
14MP0009764_decreased_sensitivity_to1.98153088
15MP0002420_abnormal_adaptive_immunity1.97828698
16MP0001819_abnormal_immune_cell1.96299299
17MP0003763_abnormal_thymus_physiology1.94285343
18MP0001790_abnormal_immune_system1.90700041
19MP0005387_immune_system_phenotype1.90700041
20MP0003436_decreased_susceptibility_to1.89978746
21MP0001968_abnormal_touch/_nociception1.89461098
22MP0005025_abnormal_response_to1.88317767
23MP0002138_abnormal_hepatobiliary_system1.86557667
24MP0009333_abnormal_splenocyte_physiolog1.85386593
25MP0001986_abnormal_taste_sensitivity1.83969110
26MP0002006_tumorigenesis1.81340060
27MP0002102_abnormal_ear_morphology1.80501454
28MP0005075_abnormal_melanosome_morpholog1.77056512
29MP0002736_abnormal_nociception_after1.69341123
30MP0008875_abnormal_xenobiotic_pharmacok1.66790341
31MP0005084_abnormal_gallbladder_morpholo1.66620199
32MP0003866_abnormal_defecation1.64335358
33MP0008872_abnormal_physiological_respon1.61321361
34MP0000465_gastrointestinal_hemorrhage1.56828916
35MP0002419_abnormal_innate_immunity1.50597313
36MP0006082_CNS_inflammation1.47638073
37MP0005645_abnormal_hypothalamus_physiol1.46406807
38MP0003646_muscle_fatigue1.42499934
39MP0000716_abnormal_immune_system1.41603980
40MP0001845_abnormal_inflammatory_respons1.38715207
41MP0002933_joint_inflammation1.38532041
42MP0000372_irregular_coat_pigmentation1.37257944
43MP0002398_abnormal_bone_marrow1.36393778
44MP0005253_abnormal_eye_physiology1.34851832
45MP0010155_abnormal_intestine_physiology1.32448913
46MP0003195_calcinosis1.31373858
47MP0003878_abnormal_ear_physiology1.31246156
48MP0005377_hearing/vestibular/ear_phenot1.31246156
49MP0001905_abnormal_dopamine_level1.27242563
50MP0000689_abnormal_spleen_morphology1.26109799
51MP0005464_abnormal_platelet_physiology1.24936822
52MP0003806_abnormal_nucleotide_metabolis1.24912930
53MP0005551_abnormal_eye_electrophysiolog1.23225889
54MP0001533_abnormal_skeleton_physiology1.22987674
55MP0006036_abnormal_mitochondrial_physio1.18454064
56MP0002405_respiratory_system_inflammati1.17628464
57MP0004145_abnormal_muscle_electrophysio1.17552442
58MP0001873_stomach_inflammation1.17270051
59MP0002722_abnormal_immune_system1.11683219
60MP0001919_abnormal_reproductive_system1.10491307
61MP0001501_abnormal_sleep_pattern1.08993610
62MP0004947_skin_inflammation1.08468407
63MP0002429_abnormal_blood_cell1.07721483
64MP0008469_abnormal_protein_level1.06607391
65MP0005360_urolithiasis1.00680249
66MP0003786_premature_aging0.99675323
67MP0002095_abnormal_skin_pigmentation0.99062729
68MP0000703_abnormal_thymus_morphology0.98316745
69MP0003011_delayed_dark_adaptation0.97983928
70MP0002653_abnormal_ependyma_morphology0.96205549
71MP0003638_abnormal_response/metabolism_0.94645916
72MP0002837_dystrophic_cardiac_calcinosis0.93750949
73MP0005083_abnormal_biliary_tract0.92391168
74MP0005085_abnormal_gallbladder_physiolo0.89239901
75MP0002876_abnormal_thyroid_physiology0.88772435
76MP0008877_abnormal_DNA_methylation0.88741969
77MP0003252_abnormal_bile_duct0.86788969
78MP0005174_abnormal_tail_pigmentation0.85846566
79MP0006035_abnormal_mitochondrial_morpho0.85676146
80MP0009763_increased_sensitivity_to0.84643762
81MP0000569_abnormal_digit_pigmentation0.83403221
82MP0004885_abnormal_endolymph0.83355719
83MP0008058_abnormal_DNA_repair0.82206865
84MP0005646_abnormal_pituitary_gland0.81950855
85MP0009697_abnormal_copulation0.81388096
86MP0005389_reproductive_system_phenotype0.78982705
87MP0006054_spinal_hemorrhage0.78476202
88MP0006276_abnormal_autonomic_nervous0.78407163
89MP0001542_abnormal_bone_strength0.78129119
90MP0008775_abnormal_heart_ventricle0.76575438
91MP0000015_abnormal_ear_pigmentation0.74784213
92MP0005332_abnormal_amino_acid0.72806663
93MP0001853_heart_inflammation0.71254306
94MP0008995_early_reproductive_senescence0.70155258
95MP0005636_abnormal_mineral_homeostasis0.69447536
96MP0001765_abnormal_ion_homeostasis0.69220297
97MP0002277_abnormal_respiratory_mucosa0.68367826
98MP0005410_abnormal_fertilization0.66933602
99MP0004142_abnormal_muscle_tone0.65977949
100MP0009745_abnormal_behavioral_response0.65438931

Predicted human phenotypes

RankGene SetZ-score
1IgG deficiency (HP:0004315)5.20220676
2Elevated erythrocyte sedimentation rate (HP:0003565)4.03249072
3Severe combined immunodeficiency (HP:0004430)3.69126546
4Congenital stationary night blindness (HP:0007642)3.26718204
53-Methylglutaconic aciduria (HP:0003535)3.20670353
6Abnormality of B cell number (HP:0010975)3.20358838
7Increased IgM level (HP:0003496)3.17981217
8Mitochondrial inheritance (HP:0001427)3.15443971
9B lymphocytopenia (HP:0010976)3.10640246
10Aplastic anemia (HP:0001915)3.10066197
11Abnormality of the prostate (HP:0008775)3.04960371
12Abnormality of eosinophils (HP:0001879)3.04377748
13T lymphocytopenia (HP:0005403)3.02375498
14Increased CSF lactate (HP:0002490)3.02000434
15Hypoproteinemia (HP:0003075)3.01143618
16Increased intramyocellular lipid droplets (HP:0012240)2.98127673
17Abnormality of T cell number (HP:0011839)2.95973472
18Hepatocellular necrosis (HP:0001404)2.91908430
19Decreased activity of mitochondrial respiratory chain (HP:0008972)2.83425296
20Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.83425296
21Abolished electroretinogram (ERG) (HP:0000550)2.82907833
22Recurrent bronchitis (HP:0002837)2.82338071
23Decreased electroretinogram (ERG) amplitude (HP:0000654)2.77698449
24Acute necrotizing encephalopathy (HP:0006965)2.76898246
25Abnormal mitochondria in muscle tissue (HP:0008316)2.74451819
26Combined immunodeficiency (HP:0005387)2.72676204
27Hepatic necrosis (HP:0002605)2.70687348
28IgM deficiency (HP:0002850)2.70462613
29Stomatitis (HP:0010280)2.70397166
30Abnormality of T cells (HP:0002843)2.66945592
31Eosinophilia (HP:0001880)2.65786199
32Thyroiditis (HP:0100646)2.65604672
33Prostate neoplasm (HP:0100787)2.65313575
34Pancreatic cysts (HP:0001737)2.53818163
35Increased muscle lipid content (HP:0009058)2.52526083
36Increased hepatocellular lipid droplets (HP:0006565)2.51660027
37Myositis (HP:0100614)2.48143183
38Increased serum lactate (HP:0002151)2.48140999
39Type 2 muscle fiber atrophy (HP:0003554)2.45756293
40Lactic acidosis (HP:0003128)2.44723716
41Decreased central vision (HP:0007663)2.42117091
42Lipid accumulation in hepatocytes (HP:0006561)2.41291879
43Molar tooth sign on MRI (HP:0002419)2.40693871
44Abnormality of midbrain morphology (HP:0002418)2.40693871
45Renal Fanconi syndrome (HP:0001994)2.37757279
46Facial diplegia (HP:0001349)2.36153264
47Exertional dyspnea (HP:0002875)2.31692795
48Acute encephalopathy (HP:0006846)2.31096994
49Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.29969418
50Congenital, generalized hypertrichosis (HP:0004540)2.25517397
51Autoimmune hemolytic anemia (HP:0001890)2.25472053
52Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.25012333
53Abnormality of alanine metabolism (HP:0010916)2.25012333
54Hyperalaninemia (HP:0003348)2.25012333
55Attenuation of retinal blood vessels (HP:0007843)2.22695343
56Progressive macrocephaly (HP:0004481)2.21013134
57Abnormality of T cell physiology (HP:0011840)2.18845923
58Generalized aminoaciduria (HP:0002909)2.18531546
59Granulocytopenia (HP:0001913)2.18520494
60Renal cortical cysts (HP:0000803)2.16160677
61Chronic diarrhea (HP:0002028)2.14651212
62Leukocytosis (HP:0001974)2.11129640
63Pustule (HP:0200039)2.10938042
64Chronic sinusitis (HP:0011109)2.10417376
65Pulmonary fibrosis (HP:0002206)2.09092076
66Retrobulbar optic neuritis (HP:0100654)2.07925642
67Optic neuritis (HP:0100653)2.07925642
68Hypothermia (HP:0002045)2.03939024
69Absent rod-and cone-mediated responses on ERG (HP:0007688)2.03157160
70Pulmonary infiltrates (HP:0002113)2.02121649
71Cerebral edema (HP:0002181)2.00759790
72Muscle fiber atrophy (HP:0100295)2.00449179
73Encephalitis (HP:0002383)1.99874446
74Dynein arm defect of respiratory motile cilia (HP:0012255)1.99389062
75Absent/shortened dynein arms (HP:0200106)1.99389062
76Bronchitis (HP:0012387)1.98417205
77True hermaphroditism (HP:0010459)1.94529439
78Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.93295607
79Abnormality of the renal cortex (HP:0011035)1.92463065
80Aplasia/hypoplasia of the uterus (HP:0008684)1.91462681
81Type I transferrin isoform profile (HP:0003642)1.90998789
82Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.89092773
83Abnormal protein N-linked glycosylation (HP:0012347)1.89092773
84Abnormal protein glycosylation (HP:0012346)1.89092773
85Abnormal glycosylation (HP:0012345)1.89092773
86Constricted visual fields (HP:0001133)1.86645697
87Stomach cancer (HP:0012126)1.83831455
88Abnormal rod and cone electroretinograms (HP:0008323)1.83417686
89Short tibia (HP:0005736)1.82570979
90Nephronophthisis (HP:0000090)1.82281885
91Progressive microcephaly (HP:0000253)1.81810076
92Pancytopenia (HP:0001876)1.81413793
93Panhypogammaglobulinemia (HP:0003139)1.80940225
94Pancreatitis (HP:0001733)1.79395455
95Pancreatic fibrosis (HP:0100732)1.79377940
96Vasculitis (HP:0002633)1.77391258
97Agammaglobulinemia (HP:0004432)1.76944093
98Hemoptysis (HP:0002105)1.73941385
99Optic disc pallor (HP:0000543)1.73053787
100Hypergammaglobulinemia (HP:0010702)1.70203401

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK4.17394301
2TAOK33.97942713
3MAP4K23.81019732
4TLK13.72634354
5TESK23.65972733
6KDR2.96682871
7ZAK2.70316215
8BCKDK2.68337412
9GRK62.46228016
10MAPKAPK32.17186426
11GRK12.13074706
12NUAK11.99013299
13MAP3K121.96012875
14ADRBK21.95835610
15BMPR21.93561225
16MAP4K11.89423841
17TIE11.67946627
18CDK191.59585450
19FES1.54064431
20TRIM281.47812424
21MST41.41490543
22SYK1.37770530
23IKBKB1.34236161
24VRK21.32862942
25KIT1.28808441
26MYLK1.26858121
27DAPK11.24530975
28ITK1.23893989
29VRK11.22020260
30TEC1.12966937
31MAP2K21.08681154
32ERBB31.07331947
33TBK11.04080230
34ZAP701.03291276
35OXSR11.01891001
36BTK0.99662584
37LIMK10.96707508
38LCK0.96242690
39CSNK1G30.94992185
40IKBKE0.94605771
41FRK0.92325571
42CSF1R0.91311303
43MAP3K140.91258566
44LYN0.88649068
45JAK30.88645046
46TESK10.85106734
47INSRR0.82463877
48MAPKAPK50.78788084
49BCR0.78281905
50JAK10.77438754
51SRPK10.77123059
52PRKCQ0.76115107
53MATK0.74137981
54RIPK40.69926037
55BMPR1B0.69869821
56CSNK1G10.69483798
57CSK0.68742835
58CSNK1G20.68178497
59CSNK1A1L0.64892436
60WNK30.64801145
61MAPK130.63995180
62MUSK0.61927042
63PIM20.61733690
64PIM10.61654776
65PTK2B0.61032738
66IGF1R0.60424044
67EIF2AK30.58488973
68RPS6KA50.57959631
69CCNB10.54439070
70HCK0.52786251
71PHKG10.52583172
72PHKG20.52583172
73TRPM70.51359492
74OBSCN0.50683628
75BLK0.49320131
76MAP2K60.49093716
77ARAF0.48766535
78PINK10.48340732
79FLT30.48201576
80BUB10.47603534
81PDK20.45902665
82ABL10.45456469
83SIK30.44804008
84ILK0.41685650
85SIK20.40665514
86CDK80.40414177
87MAP3K50.39241373
88PRKCE0.37805176
89PLK40.37655536
90EPHA30.36709278
91ADRBK10.36682739
92SCYL20.34354768
93GRK50.34195310
94WNK40.33801019
95GRK70.32754119
96PLK20.31200370
97MARK30.29946945
98DAPK30.29884347
99PRKCA0.29746323
100MAPK70.28839602

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053104.06455945
2Intestinal immune network for IgA production_Homo sapiens_hsa046723.52473068
3Allograft rejection_Homo sapiens_hsa053303.52041653
4Graft-versus-host disease_Homo sapiens_hsa053323.48242910
5Autoimmune thyroid disease_Homo sapiens_hsa053203.43204180
6Primary immunodeficiency_Homo sapiens_hsa053403.33221708
7Proteasome_Homo sapiens_hsa030503.11206843
8Type I diabetes mellitus_Homo sapiens_hsa049402.78667676
9Oxidative phosphorylation_Homo sapiens_hsa001902.50149116
10Antigen processing and presentation_Homo sapiens_hsa046122.40086558
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.17814739
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.10684815
13Parkinsons disease_Homo sapiens_hsa050122.06078636
14Rheumatoid arthritis_Homo sapiens_hsa053231.89495047
15Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.80100235
16Viral myocarditis_Homo sapiens_hsa054161.79971450
17Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.66483363
18Hematopoietic cell lineage_Homo sapiens_hsa046401.64049208
19Protein export_Homo sapiens_hsa030601.58207658
20Phototransduction_Homo sapiens_hsa047441.56951506
21RNA polymerase_Homo sapiens_hsa030201.53072726
22Staphylococcus aureus infection_Homo sapiens_hsa051501.35520076
23Leishmaniasis_Homo sapiens_hsa051401.24187646
24Alzheimers disease_Homo sapiens_hsa050101.23187034
25Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.18393371
26Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.17143294
27Nitrogen metabolism_Homo sapiens_hsa009101.12122050
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.07758432
29Huntingtons disease_Homo sapiens_hsa050161.06412598
30Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.03978489
31Regulation of autophagy_Homo sapiens_hsa041401.03217678
32Linoleic acid metabolism_Homo sapiens_hsa005911.02294844
33T cell receptor signaling pathway_Homo sapiens_hsa046601.01452325
34Systemic lupus erythematosus_Homo sapiens_hsa053221.00593787
35Homologous recombination_Homo sapiens_hsa034400.99856994
36Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.97930600
37Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.97020343
38Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.96977823
39Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.96086335
40NF-kappa B signaling pathway_Homo sapiens_hsa040640.94747699
41Primary bile acid biosynthesis_Homo sapiens_hsa001200.89697390
42Propanoate metabolism_Homo sapiens_hsa006400.88693188
43Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.84821192
44Shigellosis_Homo sapiens_hsa051310.83521867
45Tryptophan metabolism_Homo sapiens_hsa003800.83427727
46alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.83362304
47Peroxisome_Homo sapiens_hsa041460.78366066
48Sulfur metabolism_Homo sapiens_hsa009200.78146236
49NOD-like receptor signaling pathway_Homo sapiens_hsa046210.77500793
50Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.76407934
51Cardiac muscle contraction_Homo sapiens_hsa042600.75794040
52Chemical carcinogenesis_Homo sapiens_hsa052040.75693026
53SNARE interactions in vesicular transport_Homo sapiens_hsa041300.73396972
54Caffeine metabolism_Homo sapiens_hsa002320.73193750
55Arachidonic acid metabolism_Homo sapiens_hsa005900.73003909
56Fatty acid elongation_Homo sapiens_hsa000620.70314710
57Herpes simplex infection_Homo sapiens_hsa051680.68832237
58One carbon pool by folate_Homo sapiens_hsa006700.66978581
59Collecting duct acid secretion_Homo sapiens_hsa049660.66692793
60Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.66201088
61Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.65897686
62RNA degradation_Homo sapiens_hsa030180.65120487
63Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.61560337
64Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.61498618
65Fanconi anemia pathway_Homo sapiens_hsa034600.56832192
66Butanoate metabolism_Homo sapiens_hsa006500.56004869
67Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.55950503
68Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.55227680
69Pentose and glucuronate interconversions_Homo sapiens_hsa000400.54867490
70Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.54790099
71Purine metabolism_Homo sapiens_hsa002300.53391705
72Retinol metabolism_Homo sapiens_hsa008300.52193431
73Olfactory transduction_Homo sapiens_hsa047400.51935556
74Salmonella infection_Homo sapiens_hsa051320.50292559
75Legionellosis_Homo sapiens_hsa051340.50092994
76Ribosome_Homo sapiens_hsa030100.49927997
77Steroid hormone biosynthesis_Homo sapiens_hsa001400.47790733
78Measles_Homo sapiens_hsa051620.46577222
79RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.44953949
80Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.44814736
81Phagosome_Homo sapiens_hsa041450.43886927
82Tuberculosis_Homo sapiens_hsa051520.43786414
83Drug metabolism - other enzymes_Homo sapiens_hsa009830.41954959
84Taste transduction_Homo sapiens_hsa047420.41809818
85Pyrimidine metabolism_Homo sapiens_hsa002400.41782354
86Epstein-Barr virus infection_Homo sapiens_hsa051690.41755340
87Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.41577952
88Glycosaminoglycan degradation_Homo sapiens_hsa005310.39976919
89Ether lipid metabolism_Homo sapiens_hsa005650.39104813
90Basal transcription factors_Homo sapiens_hsa030220.37729322
91Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.37684431
92Cysteine and methionine metabolism_Homo sapiens_hsa002700.36253352
93Toxoplasmosis_Homo sapiens_hsa051450.36225003
94Mismatch repair_Homo sapiens_hsa034300.35008035
95Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.34793279
96Metabolic pathways_Homo sapiens_hsa011000.34412768
97Sulfur relay system_Homo sapiens_hsa041220.32610688
98Base excision repair_Homo sapiens_hsa034100.32348957
99Jak-STAT signaling pathway_Homo sapiens_hsa046300.30217764
100beta-Alanine metabolism_Homo sapiens_hsa004100.28793233

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »