ACTBP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)7.47547194
2regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.75095456
3cytidine deamination (GO:0009972)5.65234383
4cytidine metabolic process (GO:0046087)5.65234383
5cytidine catabolic process (GO:0006216)5.65234383
6pyrimidine ribonucleoside catabolic process (GO:0046133)4.83950834
7Arp2/3 complex-mediated actin nucleation (GO:0034314)4.07320051
8sequestering of actin monomers (GO:0042989)4.03358362
9RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.78397646
10tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.78397646
11actin nucleation (GO:0045010)3.70426745
12positive regulation of interleukin-8 secretion (GO:2000484)3.58695955
13negative regulation of T cell apoptotic process (GO:0070233)3.58557138
14regulation of cellular amino acid metabolic process (GO:0006521)3.57594277
15energy coupled proton transport, down electrochemical gradient (GO:0015985)3.54335754
16ATP synthesis coupled proton transport (GO:0015986)3.54335754
17cellular response to interleukin-15 (GO:0071350)3.53034752
18positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.52157678
19platelet dense granule organization (GO:0060155)3.47988198
20iron-sulfur cluster assembly (GO:0016226)3.39266924
21metallo-sulfur cluster assembly (GO:0031163)3.39266924
22positive regulation of calcium-mediated signaling (GO:0050850)3.39248063
23DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.37323463
24mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.33418825
25negative T cell selection (GO:0043383)3.31571445
26proteasome assembly (GO:0043248)3.29179885
27signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.25191631
28signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.25191631
29signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.25191631
30positive regulation of T cell mediated cytotoxicity (GO:0001916)3.23825999
31intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.23249828
32signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.23249828
33negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.18711884
34positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.13882444
35antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.10287257
36protein neddylation (GO:0045116)3.08622381
37signal transduction involved in DNA damage checkpoint (GO:0072422)3.07497514
38signal transduction involved in DNA integrity checkpoint (GO:0072401)3.07497514
39positive regulation of defense response to virus by host (GO:0002230)3.07192681
40signal transduction involved in cell cycle checkpoint (GO:0072395)3.04837251
41mature B cell differentiation involved in immune response (GO:0002313)3.04494320
42regulation of activation of Janus kinase activity (GO:0010533)3.02789584
43regulation of interleukin-8 secretion (GO:2000482)2.99681683
44regulation of chronic inflammatory response (GO:0002676)2.98358055
45antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.96645529
46regulation of T cell mediated cytotoxicity (GO:0001914)2.94644051
47antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.92343647
48negative regulation by host of viral transcription (GO:0043922)2.90888497
49positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.90603787
50negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.88051711
51regulation of T cell receptor signaling pathway (GO:0050856)2.86938932
52regulation of leukocyte mediated cytotoxicity (GO:0001910)2.86087807
53negative regulation of ligase activity (GO:0051352)2.83562978
54negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.83562978
55purine deoxyribonucleotide catabolic process (GO:0009155)2.83390854
56positive regulation of alpha-beta T cell proliferation (GO:0046641)2.83158998
57positive thymic T cell selection (GO:0045059)2.82766537
58positive regulation of natural killer cell mediated immunity (GO:0002717)2.81935654
59regulation of B cell receptor signaling pathway (GO:0050855)2.80166959
60positive regulation of cell killing (GO:0031343)2.79209926
61adenosine metabolic process (GO:0046085)2.77951556
62positive T cell selection (GO:0043368)2.76679860
63preassembly of GPI anchor in ER membrane (GO:0016254)2.75287444
64negative regulation of lymphocyte apoptotic process (GO:0070229)2.74881029
65regulation of regulatory T cell differentiation (GO:0045589)2.74711075
66negative thymic T cell selection (GO:0045060)2.73444512
67positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.72720827
68GTP biosynthetic process (GO:0006183)2.72174895
69regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.69938416
70xenobiotic catabolic process (GO:0042178)2.68480056
71base-excision repair, AP site formation (GO:0006285)2.68075094
72DNA demethylation (GO:0080111)2.67155432
73positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.64228598
74pyrimidine nucleoside catabolic process (GO:0046135)2.63138132
75positive regulation of hair cycle (GO:0042635)2.61475076
76positive regulation of hair follicle development (GO:0051798)2.61475076
77regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.61083905
78epithelial cell maturation (GO:0002070)2.60459634
79mast cell activation (GO:0045576)2.58102449
80thymic T cell selection (GO:0045061)2.57230694
81regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.57166451
82regulation of cell killing (GO:0031341)2.56604808
83DNA dealkylation (GO:0035510)2.55931750
84mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.55047537
85protein complex biogenesis (GO:0070271)2.54814355
86DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.53667969
87regulation of cellular amine metabolic process (GO:0033238)2.53320611
88electron transport chain (GO:0022900)2.51959728
89response to interferon-beta (GO:0035456)2.51669449
90positive regulation of interleukin-4 production (GO:0032753)2.49823395
91respiratory electron transport chain (GO:0022904)2.49822383
92negative regulation of oxidoreductase activity (GO:0051354)2.49189740
93nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.48877683
94regulation of calcium-mediated signaling (GO:0050848)2.47645310
95regulation of cell proliferation involved in kidney development (GO:1901722)2.47537467
96antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.47352247
97regulation of T cell apoptotic process (GO:0070232)2.46271375
98T cell costimulation (GO:0031295)2.45985240
99lymphocyte costimulation (GO:0031294)2.45928736
100positive regulation of macrophage differentiation (GO:0045651)2.45329051

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.90697405
2IRF8_22096565_ChIP-ChIP_GC-B_Human3.83003350
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.71357610
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.52323506
5ELF1_17652178_ChIP-ChIP_JURKAT_Human3.29095713
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.22201258
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.08973554
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.90698820
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.82054049
10IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.81216616
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.80527554
12FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.60172988
13NOTCH1_21737748_ChIP-Seq_TLL_Human2.59441047
14HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.59068734
15EST1_17652178_ChIP-ChIP_JURKAT_Human2.56438928
16VDR_23849224_ChIP-Seq_CD4+_Human2.43601750
17LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.29111236
18IRF8_21731497_ChIP-ChIP_J774_Mouse2.27966356
19E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.24691253
20MYB_26560356_Chip-Seq_TH2_Human2.10369121
21ZNF274_21170338_ChIP-Seq_K562_Hela2.07606351
22RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.03466288
23FOXP3_21729870_ChIP-Seq_TREG_Human1.97989205
24ETS1_20019798_ChIP-Seq_JURKAT_Human1.96424622
25FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.93898563
26SRF_21415370_ChIP-Seq_HL-1_Mouse1.93468255
27RUNX_20019798_ChIP-Seq_JUKART_Human1.88108809
28VDR_22108803_ChIP-Seq_LS180_Human1.81311969
29CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.75436730
30PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.70123750
31TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.69091604
32ELK1_19687146_ChIP-ChIP_HELA_Human1.68970240
33SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.68342760
34FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.65395543
35STAT4_19710469_ChIP-ChIP_TH1__Mouse1.64442690
36CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.63685215
37PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.62546399
38GATA3_26560356_Chip-Seq_TH2_Human1.58611466
39GATA3_27048872_Chip-Seq_THYMUS_Human1.58026784
40CREB1_15753290_ChIP-ChIP_HEK293T_Human1.54548727
41MYC_18940864_ChIP-ChIP_HL60_Human1.53516976
42FLI1_27457419_Chip-Seq_LIVER_Mouse1.51869580
43TP53_22573176_ChIP-Seq_HFKS_Human1.51704773
44HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.42179366
45LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.39444394
46ESR1_15608294_ChIP-ChIP_MCF-7_Human1.34742209
47IGF1R_20145208_ChIP-Seq_DFB_Human1.34432439
48EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.32842478
49MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.31419289
50CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.31117726
51YY1_21170310_ChIP-Seq_MESCs_Mouse1.29933766
52AR_20517297_ChIP-Seq_VCAP_Human1.28638845
53MYB_26560356_Chip-Seq_TH1_Human1.28561420
54EGR1_23403033_ChIP-Seq_LIVER_Mouse1.26207063
55RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.23755050
56CIITA_25753668_ChIP-Seq_RAJI_Human1.23713461
57FOXA1_27270436_Chip-Seq_PROSTATE_Human1.23059004
58FOXA1_25329375_ChIP-Seq_VCAP_Human1.23059004
59ER_23166858_ChIP-Seq_MCF-7_Human1.22959087
60HOXB4_20404135_ChIP-ChIP_EML_Mouse1.22437621
61TDRD3_21172665_ChIP-Seq_MCF-7_Human1.22425123
62NANOG_20526341_ChIP-Seq_ESCs_Human1.22350971
63SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.21960530
64EWS_26573619_Chip-Seq_HEK293_Human1.21432043
65CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.20997513
66GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.20644101
67IRF1_19129219_ChIP-ChIP_H3396_Human1.20380606
68EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.19243957
69PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.18251511
70TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.15669224
71TAF2_19829295_ChIP-Seq_ESCs_Human1.14545499
72MYC_18358816_ChIP-ChIP_MESCs_Mouse1.14107306
73FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10403056
74ERA_21632823_ChIP-Seq_H3396_Human1.09754526
75TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.09696186
76NCOR_22424771_ChIP-Seq_293T_Human1.09421276
77POU5F1_16153702_ChIP-ChIP_HESCs_Human1.08210994
78AUTS2_25519132_ChIP-Seq_293T-REX_Human1.07808545
79PADI4_21655091_ChIP-ChIP_MCF-7_Human1.07753346
80MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.06795079
81POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.06310641
82PCGF2_27294783_Chip-Seq_ESCs_Mouse1.04866359
83BCL6_27268052_Chip-Seq_Bcells_Human1.03713152
84PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01690522
85CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.01458651
86HOXB7_26014856_ChIP-Seq_BT474_Human1.01058181
87CTBP1_25329375_ChIP-Seq_LNCAP_Human0.98488505
88GATA3_21878914_ChIP-Seq_MCF-7_Human0.97471808
89GABP_19822575_ChIP-Seq_HepG2_Human0.97112935
90FOXA1_21572438_ChIP-Seq_LNCaP_Human0.95415947
91DCP1A_22483619_ChIP-Seq_HELA_Human0.93861196
92BMI1_23680149_ChIP-Seq_NPCS_Mouse0.92295709
93FOXH1_21741376_ChIP-Seq_EPCs_Human0.91651900
94UTX_26944678_Chip-Seq_JUKART_Human0.91537107
95EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.90786258
96TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.90586982
97NANOG_19829295_ChIP-Seq_ESCs_Human0.90561375
98SOX2_19829295_ChIP-Seq_ESCs_Human0.90561375
99BCAT_22108803_ChIP-Seq_LS180_Human0.89448396
100E2F1_18555785_ChIP-Seq_MESCs_Mouse0.89095315

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to5.03233140
2MP0001835_abnormal_antigen_presentation2.85999200
3MP0002736_abnormal_nociception_after2.76569343
4MP0002909_abnormal_adrenal_gland2.60459982
5MP0009785_altered_susceptibility_to2.54879525
6MP0003763_abnormal_thymus_physiology2.49297205
7MP0002653_abnormal_ependyma_morphology2.28619801
8MP0000465_gastrointestinal_hemorrhage2.26736358
9MP0002148_abnormal_hypersensitivity_rea2.25168978
10MP0001968_abnormal_touch/_nociception2.24247069
11MP0005000_abnormal_immune_tolerance2.23619388
12MP0008875_abnormal_xenobiotic_pharmacok2.18590653
13MP0001800_abnormal_humoral_immune2.12690100
14MP0003724_increased_susceptibility_to2.12292369
15MP0005646_abnormal_pituitary_gland2.11816444
16MP0008872_abnormal_physiological_respon2.11417033
17MP0002166_altered_tumor_susceptibility2.08476772
18MP0003806_abnormal_nucleotide_metabolis1.95667567
19MP0009333_abnormal_splenocyte_physiolog1.92334680
20MP0005075_abnormal_melanosome_morpholog1.91562174
21MP0005360_urolithiasis1.91121292
22MP0002723_abnormal_immune_serum1.86158634
23MP0002420_abnormal_adaptive_immunity1.85809856
24MP0006072_abnormal_retinal_apoptosis1.85212370
25MP0001819_abnormal_immune_cell1.83921640
26MP0005025_abnormal_response_to1.83048370
27MP0001873_stomach_inflammation1.82622278
28MP0005645_abnormal_hypothalamus_physiol1.74627563
29MP0002452_abnormal_antigen_presenting1.72865440
30MP0002006_tumorigenesis1.67821132
31MP0002102_abnormal_ear_morphology1.67143503
32MP0003646_muscle_fatigue1.64154000
33MP0001790_abnormal_immune_system1.55741415
34MP0005387_immune_system_phenotype1.55741415
35MP0000372_irregular_coat_pigmentation1.54102691
36MP0003866_abnormal_defecation1.53112432
37MP0000685_abnormal_immune_system1.48836092
38MP0001919_abnormal_reproductive_system1.48311322
39MP0002277_abnormal_respiratory_mucosa1.45770972
40MP0003195_calcinosis1.44349595
41MP0002398_abnormal_bone_marrow1.43883204
42MP0000716_abnormal_immune_system1.43675045
43MP0005084_abnormal_gallbladder_morpholo1.42674456
44MP0002876_abnormal_thyroid_physiology1.41754518
45MP0006292_abnormal_olfactory_placode1.35624173
46MP0009764_decreased_sensitivity_to1.35311185
47MP0002098_abnormal_vibrissa_morphology1.33080817
48MP0000689_abnormal_spleen_morphology1.30366074
49MP0003011_delayed_dark_adaptation1.29398989
50MP0003786_premature_aging1.28703656
51MP0006276_abnormal_autonomic_nervous1.27820319
52MP0003878_abnormal_ear_physiology1.25703637
53MP0005377_hearing/vestibular/ear_phenot1.25703637
54MP0004147_increased_porphyrin_level1.24420926
55MP0000703_abnormal_thymus_morphology1.23926344
56MP0001845_abnormal_inflammatory_respons1.23348891
57MP0001529_abnormal_vocalization1.20359974
58MP0002722_abnormal_immune_system1.20106552
59MP0005253_abnormal_eye_physiology1.18035086
60MP0005551_abnormal_eye_electrophysiolog1.17321553
61MP0002429_abnormal_blood_cell1.17177452
62MP0002933_joint_inflammation1.12792493
63MP0004381_abnormal_hair_follicle1.11610894
64MP0008995_early_reproductive_senescence1.11581737
65MP0001542_abnormal_bone_strength1.08342237
66MP0002419_abnormal_innate_immunity1.07811781
67MP0005389_reproductive_system_phenotype1.06477654
68MP0002405_respiratory_system_inflammati1.05497915
69MP0001764_abnormal_homeostasis1.04671137
70MP0000579_abnormal_nail_morphology1.04520499
71MP0003436_decreased_susceptibility_to1.03616123
72MP0006082_CNS_inflammation1.02808984
73MP0001905_abnormal_dopamine_level1.02531682
74MP0002009_preneoplasia1.00661144
75MP0003638_abnormal_response/metabolism_0.97810967
76MP0001853_heart_inflammation0.97386142
77MP0002837_dystrophic_cardiac_calcinosis0.96450667
78MP0005410_abnormal_fertilization0.92727738
79MP0009697_abnormal_copulation0.92052333
80MP0005464_abnormal_platelet_physiology0.90108661
81MP0010155_abnormal_intestine_physiology0.89904837
82MP0008877_abnormal_DNA_methylation0.89821837
83MP0008469_abnormal_protein_level0.88696461
84MP0002693_abnormal_pancreas_physiology0.87458268
85MP0002160_abnormal_reproductive_system0.83415697
86MP0001533_abnormal_skeleton_physiology0.81193742
87MP0005083_abnormal_biliary_tract0.80085045
88MP0006036_abnormal_mitochondrial_physio0.79320574
89MP0008058_abnormal_DNA_repair0.79252444
90MP0010329_abnormal_lipoprotein_level0.78097199
91MP0002163_abnormal_gland_morphology0.77773007
92MP0002019_abnormal_tumor_incidence0.74282714
93MP0000639_abnormal_adrenal_gland0.72361040
94MP0003718_maternal_effect0.71938016
95MP0004142_abnormal_muscle_tone0.67940350
96MP0002138_abnormal_hepatobiliary_system0.67724888
97MP0005636_abnormal_mineral_homeostasis0.65675003
98MP0001119_abnormal_female_reproductive0.65612252
99MP0001984_abnormal_olfaction0.64806205
100MP0008789_abnormal_olfactory_epithelium0.64031032

Predicted human phenotypes

RankGene SetZ-score
1Concave nail (HP:0001598)4.85969150
2IgG deficiency (HP:0004315)4.42625645
3Aplastic anemia (HP:0001915)4.10030180
4Abnormality of lateral ventricle (HP:0030047)3.94547781
5Severe combined immunodeficiency (HP:0004430)3.86326777
6T lymphocytopenia (HP:0005403)3.57427943
7Elevated erythrocyte sedimentation rate (HP:0003565)3.53144354
8Abnormality of T cell number (HP:0011839)3.41104591
9Mitochondrial inheritance (HP:0001427)3.21758151
10Hypoproteinemia (HP:0003075)3.16086522
11Abolished electroretinogram (ERG) (HP:0000550)3.15316339
12Congenital stationary night blindness (HP:0007642)3.12599737
133-Methylglutaconic aciduria (HP:0003535)3.08751581
14Hepatocellular necrosis (HP:0001404)3.08495898
15Decreased electroretinogram (ERG) amplitude (HP:0000654)3.07744733
16Increased CSF lactate (HP:0002490)2.97936410
17Thyroiditis (HP:0100646)2.97926225
18Increased intramyocellular lipid droplets (HP:0012240)2.97535152
19Combined immunodeficiency (HP:0005387)2.91139610
20Increased IgM level (HP:0003496)2.84994279
21Increased hepatocellular lipid droplets (HP:0006565)2.84286662
22Acute necrotizing encephalopathy (HP:0006965)2.78749363
23Hepatic necrosis (HP:0002605)2.77761068
24Abnormality of T cells (HP:0002843)2.73095492
25Abnormality of B cell number (HP:0010975)2.72824656
26Decreased central vision (HP:0007663)2.70844013
27Decreased activity of mitochondrial respiratory chain (HP:0008972)2.67243195
28Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.67243195
29Attenuation of retinal blood vessels (HP:0007843)2.66896055
30Abnormality of the prostate (HP:0008775)2.66564794
31Abnormal mitochondria in muscle tissue (HP:0008316)2.65963598
32Lipid accumulation in hepatocytes (HP:0006561)2.64923792
33B lymphocytopenia (HP:0010976)2.62374434
34Abnormality of eosinophils (HP:0001879)2.58517596
35Stomatitis (HP:0010280)2.53859410
36Constricted visual fields (HP:0001133)2.51823263
37Increased muscle lipid content (HP:0009058)2.47725378
38Renal Fanconi syndrome (HP:0001994)2.42014654
39Increased serum lactate (HP:0002151)2.40780998
40Absent rod-and cone-mediated responses on ERG (HP:0007688)2.34243208
41Acute encephalopathy (HP:0006846)2.33449892
42Generalized aminoaciduria (HP:0002909)2.33147539
43Autoimmune hemolytic anemia (HP:0001890)2.31571261
44Methylmalonic acidemia (HP:0002912)2.26385772
45Hypotrichosis (HP:0001006)2.22968343
46Abnormality of alanine metabolism (HP:0010916)2.22340524
47Hyperalaninemia (HP:0003348)2.22340524
48Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.22340524
49Progressive macrocephaly (HP:0004481)2.22193483
50Exertional dyspnea (HP:0002875)2.21478086
51Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.20326338
52Methylmalonic aciduria (HP:0012120)2.18109139
53Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.17419297
54Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.15718913
55Abnormal protein N-linked glycosylation (HP:0012347)2.15718913
56Abnormal protein glycosylation (HP:0012346)2.15718913
57Abnormal glycosylation (HP:0012345)2.15718913
58Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.15407621
59Pancreatic cysts (HP:0001737)2.14983009
60Eosinophilia (HP:0001880)2.14242645
61Pancytopenia (HP:0001876)2.14018996
62Prostate neoplasm (HP:0100787)2.11374995
63Abnormality of the phalanges of the 2nd finger (HP:0009541)2.10349268
64Progressive microcephaly (HP:0000253)2.09170188
65Lactic acidosis (HP:0003128)2.08570348
66Keratoconjunctivitis (HP:0001096)2.08161202
67Aplasia/hypoplasia of the uterus (HP:0008684)2.07729874
68Chronic diarrhea (HP:0002028)2.06737708
69Abnormality of aspartate family amino acid metabolism (HP:0010899)2.06204295
70Keratoconjunctivitis sicca (HP:0001097)2.04901376
71Short tibia (HP:0005736)2.04151033
72Type I transferrin isoform profile (HP:0003642)2.03398738
73Cerebral edema (HP:0002181)2.01527312
74Dynein arm defect of respiratory motile cilia (HP:0012255)2.00694229
75Absent/shortened dynein arms (HP:0200106)2.00694229
76Hypoplasia of the uterus (HP:0000013)1.99624058
77Myositis (HP:0100614)1.96385543
78Abnormality of the phalanges of the 5th finger (HP:0004213)1.94184050
79Cerebral palsy (HP:0100021)1.90789582
80Renal cortical cysts (HP:0000803)1.90659827
81Abnormality of T cell physiology (HP:0011840)1.88138606
82Abnormal rod and cone electroretinograms (HP:0008323)1.86399580
83Lethargy (HP:0001254)1.85599188
84Leukocytosis (HP:0001974)1.83885966
85Pustule (HP:0200039)1.83243895
86Encephalitis (HP:0002383)1.82863073
87Neonatal respiratory distress (HP:0002643)1.81373034
88Abnormality of the parietal bone (HP:0002696)1.80501433
89Joint swelling (HP:0001386)1.80189724
90Aplasia/Hypoplasia of the tibia (HP:0005772)1.79564358
91Failure to thrive in infancy (HP:0001531)1.79416600
92Congenital, generalized hypertrichosis (HP:0004540)1.78672065
93Dicarboxylic aciduria (HP:0003215)1.76965229
94Abnormality of dicarboxylic acid metabolism (HP:0010995)1.76965229
95Metaphyseal dysplasia (HP:0100255)1.75769339
96Widely patent fontanelles and sutures (HP:0004492)1.75656206
97True hermaphroditism (HP:0010459)1.74965662
98Dysautonomia (HP:0002459)1.73467079
99Molar tooth sign on MRI (HP:0002419)1.73442321
100Abnormality of midbrain morphology (HP:0002418)1.73442321

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK24.73621961
2TXK4.25232773
3KDR3.83553767
4VRK23.15719711
5BCKDK2.82489498
6ZAK2.70601003
7TAOK32.69034527
8TLK12.63953823
9TRIM282.22427071
10MAP4K22.18155841
11NUAK12.13711714
12TESK12.13625450
13PIM21.96348562
14MAP3K121.93188386
15MUSK1.90185110
16LIMK11.89535630
17VRK11.86389474
18EPHA21.70999090
19GRK11.67752943
20ADRBK21.64435128
21GRK61.63087050
22BUB11.54823118
23MAP4K11.46545841
24MST41.45304768
25SCYL21.43753244
26MAP2K21.33204074
27DAPK11.33012835
28MAPKAPK31.21558048
29IKBKE1.19458989
30ITK1.17748715
31MYLK1.05919341
32IKBKB1.05078983
33CSNK1G31.04234512
34BMPR21.03874586
35PINK11.02636625
36SYK1.01493462
37CSF1R0.93960330
38FES0.90791637
39PIK3CA0.90323151
40MAP2K70.86337663
41PIM10.85485836
42GRK70.83924563
43CSNK1A1L0.81730043
44TIE10.80758565
45TEC0.77073564
46FRK0.74775947
47PRKCQ0.74750301
48LCK0.74284508
49TBK10.73757001
50INSRR0.72552498
51CSNK1G20.71477914
52ERBB30.71343399
53SRPK10.70647620
54RPS6KA50.68965017
55LYN0.68856592
56WNK30.68812823
57CSNK1G10.68371696
58MAP3K110.67929410
59ADRBK10.67325707
60EIF2AK30.66546764
61TNK20.65640055
62AURKA0.61062774
63BTK0.60573885
64EIF2AK20.59727806
65KIT0.58922857
66GRK50.57970249
67TAF10.57582384
68ZAP700.55534603
69CSK0.55447468
70BCR0.50050880
71BMPR1B0.47133311
72RPS6KA40.45002835
73CDK190.44667036
74IGF1R0.44559728
75STK160.43637193
76CCNB10.40786753
77DYRK20.39165860
78MAPKAPK20.38697936
79HIPK20.35928469
80WNK40.35444892
81MAPK130.35259862
82ABL10.34959070
83DAPK30.34349324
84CSNK1A10.33754691
85JAK30.33718134
86ATR0.33563989
87PRKCE0.33489127
88CSNK2A10.33154928
89OXSR10.32648371
90PRKCA0.32365427
91MAPKAPK50.30278196
92MAPK150.29105777
93CHUK0.27803179
94SIK30.27415524
95MAP2K10.27159216
96CAMKK20.26187712
97ROCK10.25671726
98RIPK40.25663385
99CDK60.25580815
100CAMK2A0.25421246

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.48734231
2Primary immunodeficiency_Homo sapiens_hsa053403.99287047
3Oxidative phosphorylation_Homo sapiens_hsa001902.77942003
4Graft-versus-host disease_Homo sapiens_hsa053322.68608761
5Allograft rejection_Homo sapiens_hsa053302.65507423
6Autoimmune thyroid disease_Homo sapiens_hsa053202.64274113
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.50270951
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.39337300
9Asthma_Homo sapiens_hsa053102.36791939
10Antigen processing and presentation_Homo sapiens_hsa046122.33015088
11Parkinsons disease_Homo sapiens_hsa050122.27989607
12Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.13695220
13Type I diabetes mellitus_Homo sapiens_hsa049402.12162674
14RNA polymerase_Homo sapiens_hsa030201.93114825
15Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.75015573
16Hematopoietic cell lineage_Homo sapiens_hsa046401.68374936
17Protein export_Homo sapiens_hsa030601.68174329
18Phototransduction_Homo sapiens_hsa047441.64823176
19Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.59495899
20Rheumatoid arthritis_Homo sapiens_hsa053231.59283866
21Sulfur metabolism_Homo sapiens_hsa009201.56803541
22Alzheimers disease_Homo sapiens_hsa050101.44056083
23Homologous recombination_Homo sapiens_hsa034401.29324192
24Huntingtons disease_Homo sapiens_hsa050161.25053279
25Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.24684070
26Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.23768295
27Systemic lupus erythematosus_Homo sapiens_hsa053221.18268232
28Viral myocarditis_Homo sapiens_hsa054161.18112321
29Tryptophan metabolism_Homo sapiens_hsa003801.13112120
30Chemical carcinogenesis_Homo sapiens_hsa052041.12910273
31Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.11977409
32Caffeine metabolism_Homo sapiens_hsa002321.10656472
33Steroid hormone biosynthesis_Homo sapiens_hsa001401.08962061
34DNA replication_Homo sapiens_hsa030301.08729165
35Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.07992566
36Sulfur relay system_Homo sapiens_hsa041221.06566865
37Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.05850104
38Nitrogen metabolism_Homo sapiens_hsa009101.05291982
39Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.05030241
40NF-kappa B signaling pathway_Homo sapiens_hsa040640.99783807
41Pyrimidine metabolism_Homo sapiens_hsa002400.98284281
42Olfactory transduction_Homo sapiens_hsa047400.98069589
43Retinol metabolism_Homo sapiens_hsa008300.96601463
44T cell receptor signaling pathway_Homo sapiens_hsa046600.96521654
45Fanconi anemia pathway_Homo sapiens_hsa034600.95275665
46Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.94946313
47Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.91620082
48Peroxisome_Homo sapiens_hsa041460.91454030
49Base excision repair_Homo sapiens_hsa034100.90700980
50Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.89326725
51Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.88337648
52Cardiac muscle contraction_Homo sapiens_hsa042600.88271941
53RNA degradation_Homo sapiens_hsa030180.88195740
54Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.87975500
55Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.86678618
56Drug metabolism - other enzymes_Homo sapiens_hsa009830.84222313
57Fatty acid elongation_Homo sapiens_hsa000620.83082790
58SNARE interactions in vesicular transport_Homo sapiens_hsa041300.81700891
59Linoleic acid metabolism_Homo sapiens_hsa005910.79560425
60Mismatch repair_Homo sapiens_hsa034300.77485438
61Ribosome_Homo sapiens_hsa030100.74427418
62Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.72607729
63Collecting duct acid secretion_Homo sapiens_hsa049660.70779637
64Butanoate metabolism_Homo sapiens_hsa006500.70682348
65Purine metabolism_Homo sapiens_hsa002300.70639238
66Propanoate metabolism_Homo sapiens_hsa006400.70026204
67Pentose and glucuronate interconversions_Homo sapiens_hsa000400.67396820
68Shigellosis_Homo sapiens_hsa051310.66243292
69alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.65197315
70Arachidonic acid metabolism_Homo sapiens_hsa005900.65182619
71Basal transcription factors_Homo sapiens_hsa030220.63448081
72Selenocompound metabolism_Homo sapiens_hsa004500.63343532
73Measles_Homo sapiens_hsa051620.61227810
74One carbon pool by folate_Homo sapiens_hsa006700.59501833
75Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.56914746
76Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.56666249
77Herpes simplex infection_Homo sapiens_hsa051680.54878071
78Spliceosome_Homo sapiens_hsa030400.54281067
79Steroid biosynthesis_Homo sapiens_hsa001000.54131229
80Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.53354327
81Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.52580116
82Primary bile acid biosynthesis_Homo sapiens_hsa001200.52449344
83Metabolic pathways_Homo sapiens_hsa011000.49661716
84Nucleotide excision repair_Homo sapiens_hsa034200.49439188
85Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.47989056
86Cysteine and methionine metabolism_Homo sapiens_hsa002700.46924519
87RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.44170875
88Staphylococcus aureus infection_Homo sapiens_hsa051500.43375845
89Salmonella infection_Homo sapiens_hsa051320.43071499
90Legionellosis_Homo sapiens_hsa051340.42820086
91Epstein-Barr virus infection_Homo sapiens_hsa051690.41971227
92Regulation of autophagy_Homo sapiens_hsa041400.40268199
93Glutathione metabolism_Homo sapiens_hsa004800.37527924
94NOD-like receptor signaling pathway_Homo sapiens_hsa046210.35000712
95Phagosome_Homo sapiens_hsa041450.34110154
96Maturity onset diabetes of the young_Homo sapiens_hsa049500.33082708
97beta-Alanine metabolism_Homo sapiens_hsa004100.33021784
98Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.32703037
99Ether lipid metabolism_Homo sapiens_hsa005650.32224159
100Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.31125318

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