ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	cobalamin metabolic process (GO:0009235)	5.54086021
2	DNA deamination (GO:0045006)	5.10139311
3	platelet dense granule organization (GO:0060155)	4.36516755
4	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	4.21370597
5	regulation of memory T cell differentiation (GO:0043380)	3.99596260
6	protein neddylation (GO:0045116)	3.96559773
7	proteasome assembly (GO:0043248)	3.82626833
8	regulation of cellular amino acid metabolic process (GO:0006521)	3.65118366
9	L-fucose catabolic process (GO:0042355)	3.50230631
10	fucose catabolic process (GO:0019317)	3.50230631
11	L-fucose metabolic process (GO:0042354)	3.50230631
12	water-soluble vitamin biosynthetic process (GO:0042364)	3.49640416
13	respiratory chain complex IV assembly (GO:0008535)	3.43167688
14	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	3.41668927
15	response to gravity (GO:0009629)	3.37327341
16	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	3.33578881
17	DNA catabolic process, exonucleolytic (GO:0000738)	3.29879566
18	xenobiotic catabolic process (GO:0042178)	3.25808716
19	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.18094819
20	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.18094819
21	cellular response to interleukin-15 (GO:0071350)	3.16952564
22	rRNA catabolic process (GO:0016075)	3.10058531
23	preassembly of GPI anchor in ER membrane (GO:0016254)	3.09609654
24	multicellular organism reproduction (GO:0032504)	3.07651973
25	positive regulation of defense response to virus by host (GO:0002230)	3.07284979
26	protein deneddylation (GO:0000338)	3.06851514
27	response to pheromone (GO:0019236)	3.05138835
28	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	3.03840675
29	rRNA modification (GO:0000154)	3.02888043
30	negative regulation of thymocyte apoptotic process (GO:0070244)	3.02243862
31	adenosine metabolic process (GO:0046085)	2.97252511
32	sleep (GO:0030431)	2.96267024
33	negative regulation of mast cell activation (GO:0033004)	2.94162501
34	DNA double-strand break processing (GO:0000729)	2.93984297
35	rRNA methylation (GO:0031167)	2.91335717
36	regulation of defense response to virus by host (GO:0050691)	2.90820700
37	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.90521158
38	cullin deneddylation (GO:0010388)	2.89016966
39	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.88273729
40	resolution of meiotic recombination intermediates (GO:0000712)	2.86976191
41	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.84982297
42	ATP synthesis coupled proton transport (GO:0015986)	2.84982297
43	negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)	2.84571317
44	regulation of acute inflammatory response to antigenic stimulus (GO:0002864)	2.83980795
45	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.83060163
46	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.83060163
47	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.83060163
48	cytidine deamination (GO:0009972)	2.82270888
49	cytidine metabolic process (GO:0046087)	2.82270888
50	cytidine catabolic process (GO:0006216)	2.82270888
51	protein polyglutamylation (GO:0018095)	2.81969022
52	regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)	2.79441728
53	protein complex biogenesis (GO:0070271)	2.78236246
54	mast cell degranulation (GO:0043303)	2.77207847
55	mast cell activation involved in immune response (GO:0002279)	2.77207847
56	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.76768641
57	positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)	2.76625738
58	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.76440757
59	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.76440757
60	positive regulation of alpha-beta T cell proliferation (GO:0046641)	2.72759465
61	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.72120783
62	regulation of hypersensitivity (GO:0002883)	2.70983470
63	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.70790238
64	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.70790238
65	NADH dehydrogenase complex assembly (GO:0010257)	2.70790238
66	cytochrome complex assembly (GO:0017004)	2.69744436
67	endoderm formation (GO:0001706)	2.69511963
68	regulation of metalloenzyme activity (GO:0048552)	2.69038167
69	regulation of interleukin-8 secretion (GO:2000482)	2.68093258
70	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.66543540
71	mast cell activation (GO:0045576)	2.65985652
72	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.62648563
73	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.62648563
74	positive regulation of T cell mediated cytotoxicity (GO:0001916)	2.60141466
75	regulation of T cell mediated cytotoxicity (GO:0001914)	2.59489786
76	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	2.58613254
77	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.58572648
78	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.57985916
79	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.57213715
80	regulation of mitotic spindle checkpoint (GO:1903504)	2.57213715
81	positive regulation of activated T cell proliferation (GO:0042104)	2.57005540
82	mitochondrial respiratory chain complex assembly (GO:0033108)	2.56481525
83	response to interferon-beta (GO:0035456)	2.56454735
84	regulation of T cell receptor signaling pathway (GO:0050856)	2.52840527
85	anterograde synaptic vesicle transport (GO:0048490)	2.51802974
86	regulation of cellular amine metabolic process (GO:0033238)	2.51616337
87	L-methionine salvage (GO:0071267)	2.51151192
88	L-methionine biosynthetic process (GO:0071265)	2.51151192
89	amino acid salvage (GO:0043102)	2.51151192
90	piRNA metabolic process (GO:0034587)	2.49100370
91	digestion (GO:0007586)	2.48760775
92	protein-cofactor linkage (GO:0018065)	2.48656705
93	negative regulation of inflammatory response to antigenic stimulus (GO:0002862)	2.47740588
94	positive regulation of DNA recombination (GO:0045911)	2.46956522
95	auditory receptor cell stereocilium organization (GO:0060088)	2.46863752
96	positive regulation of interleukin-17 production (GO:0032740)	2.46357949
97	mannosylation (GO:0097502)	2.45938294
98	fusion of sperm to egg plasma membrane (GO:0007342)	2.45869306
99	regulation of inflammatory response to antigenic stimulus (GO:0002861)	2.45495799
100	leukotriene biosynthetic process (GO:0019370)	2.43705952

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.88948380
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.43045680
3	ZNF274_21170338_ChIP-Seq_K562_Hela	2.88708684
4	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.75611864
5	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.68487694
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.58800262
7	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.54176746
8	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.40107961
9	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.39958134
10	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.38585009
11	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.31474285
12	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	2.29148660
13	VDR_22108803_ChIP-Seq_LS180_Human	2.28645236
14	ELK1_19687146_ChIP-ChIP_HELA_Human	2.22002998
15	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	2.06146832
16	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	2.04160535
17	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.03857943
18	VDR_23849224_ChIP-Seq_CD4+_Human	2.03604346
19	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.03105641
20	IRF1_19129219_ChIP-ChIP_H3396_Human	1.94546074
21	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.87268399
22	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.84287237
23	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.79540467
24	EWS_26573619_Chip-Seq_HEK293_Human	1.74405001
25	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.73589636
26	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.68378627
27	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.67408381
28	FOXP3_21729870_ChIP-Seq_TREG_Human	1.65002842
29	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.64399616
30	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.64186755
31	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.61329229
32	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.61266027
33	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.61241939
34	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.59568623
35	GATA3_26560356_Chip-Seq_TH2_Human	1.58964296
36	P300_19829295_ChIP-Seq_ESCs_Human	1.56527108
37	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.54053335
38	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.52185684
39	MYC_18940864_ChIP-ChIP_HL60_Human	1.50683122
40	TP53_22573176_ChIP-Seq_HFKS_Human	1.48599419
41	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.47240513
42	IGF1R_20145208_ChIP-Seq_DFB_Human	1.45825776
43	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.45298420
44	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.45250841
45	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.44928434
46	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.44146695
47	GBX2_23144817_ChIP-Seq_PC3_Human	1.40759437
48	CBP_20019798_ChIP-Seq_JUKART_Human	1.39218731
49	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.39218731
50	AR_20517297_ChIP-Seq_VCAP_Human	1.38869817
51	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.38382023
52	NANOG_19829295_ChIP-Seq_ESCs_Human	1.38052964
53	SOX2_19829295_ChIP-Seq_ESCs_Human	1.38052964
54	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.37968377
55	BCAT_22108803_ChIP-Seq_LS180_Human	1.37960096
56	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.32947875
57	ER_23166858_ChIP-Seq_MCF-7_Human	1.32918671
58	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.31933267
59	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.31489142
60	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.31489142
61	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.31336179
62	RUNX_20019798_ChIP-Seq_JUKART_Human	1.29526674
63	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.28174384
64	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.27401552
65	TAF15_26573619_Chip-Seq_HEK293_Human	1.27077146
66	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.26120773
67	NCOR_22424771_ChIP-Seq_293T_Human	1.26057755
68	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.24476066
69	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.23348711
70	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.21574354
71	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.21484846
72	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.16303139
73	NANOG_20526341_ChIP-Seq_ESCs_Human	1.15704138
74	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.15666430
75	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.14917906
76	TAF2_19829295_ChIP-Seq_ESCs_Human	1.13453521
77	HOXB7_26014856_ChIP-Seq_BT474_Human	1.12238580
78	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.11973947
79	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.11821616
80	TCF4_22108803_ChIP-Seq_LS180_Human	1.09968390
81	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.06043847
82	MYC_19829295_ChIP-Seq_ESCs_Human	1.04400451
83	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.03907844
84	FUS_26573619_Chip-Seq_HEK293_Human	1.03865651
85	MYB_26560356_Chip-Seq_TH2_Human	1.03321162
86	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.03122307
87	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.01262094
88	GATA2_21666600_ChIP-Seq_HMVEC_Human	1.00524433
89	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.00215182
90	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.99691672
91	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.96865922
92	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.96096943
93	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.95209455
94	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	0.94845074
95	SMAD4_21799915_ChIP-Seq_A2780_Human	0.94831074
96	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.94536800
97	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.94160344
98	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	0.94080946
99	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.93882296
100	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.92862808

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005084_abnormal_gallbladder_morpholo	3.73236631
2	MP0005671_abnormal_response_to	3.35130140
3	MP0002736_abnormal_nociception_after	2.83483957
4	MP0008872_abnormal_physiological_respon	2.72933468
5	MP0003724_increased_susceptibility_to	2.62453025
6	MP0001835_abnormal_antigen_presentation	2.57811473
7	MP0005083_abnormal_biliary_tract	2.41643842
8	MP0001968_abnormal_touch/_nociception	2.37736114
9	MP0003011_delayed_dark_adaptation	2.29394465
10	MP0003806_abnormal_nucleotide_metabolis	2.28769577
11	MP0002876_abnormal_thyroid_physiology	2.22660104
12	MP0002148_abnormal_hypersensitivity_rea	2.18056886
13	MP0000372_irregular_coat_pigmentation	2.12655304
14	MP0008877_abnormal_DNA_methylation	2.11229577
15	MP0003195_calcinosis	2.10743868
16	MP0006072_abnormal_retinal_apoptosis	2.09251638
17	MP0005410_abnormal_fertilization	1.94043351
18	MP0003718_maternal_effect	1.84039117
19	MP0002166_altered_tumor_susceptibility	1.83921214
20	MP0008875_abnormal_xenobiotic_pharmacok	1.81743176
21	MP0005167_abnormal_blood-brain_barrier	1.79279274
22	MP0000685_abnormal_immune_system	1.74849189
23	MP0008058_abnormal_DNA_repair	1.71196629
24	MP0005075_abnormal_melanosome_morpholog	1.70271405
25	MP0002653_abnormal_ependyma_morphology	1.67503590
26	MP0005000_abnormal_immune_tolerance	1.62905183
27	MP0005551_abnormal_eye_electrophysiolog	1.58184417
28	MP0003186_abnormal_redox_activity	1.58123167
29	MP0001800_abnormal_humoral_immune	1.55455693
30	MP0006054_spinal_hemorrhage	1.52601529
31	MP0003646_muscle_fatigue	1.52403894
32	MP0006036_abnormal_mitochondrial_physio	1.51644800
33	MP0005253_abnormal_eye_physiology	1.49649838
34	MP0002837_dystrophic_cardiac_calcinosis	1.49296057
35	MP0002006_tumorigenesis	1.46896363
36	MP0002928_abnormal_bile_duct	1.46424402
37	MP0002163_abnormal_gland_morphology	1.45550377
38	MP0002138_abnormal_hepatobiliary_system	1.44371795
39	MP0000465_gastrointestinal_hemorrhage	1.41424557
40	MP0001529_abnormal_vocalization	1.41224006
41	MP0003763_abnormal_thymus_physiology	1.39433535
42	MP0003252_abnormal_bile_duct	1.33547291
43	MP0002723_abnormal_immune_serum	1.32118979
44	MP0003950_abnormal_plasma_membrane	1.31462334
45	MP0001984_abnormal_olfaction	1.26862132
46	MP0002452_abnormal_antigen_presenting	1.26215883
47	MP0001853_heart_inflammation	1.23797814
48	MP0004885_abnormal_endolymph	1.23516368
49	MP0002102_abnormal_ear_morphology	1.21008105
50	MP0001819_abnormal_immune_cell	1.20779550
51	MP0002420_abnormal_adaptive_immunity	1.19945235
52	MP0001661_extended_life_span	1.18850971
53	MP0001879_abnormal_lymphatic_vessel	1.18018434
54	MP0001790_abnormal_immune_system	1.15492316
55	MP0005387_immune_system_phenotype	1.15492316
56	MP0009785_altered_susceptibility_to	1.14764636
57	MP0005464_abnormal_platelet_physiology	1.14489562
58	MP0009764_decreased_sensitivity_to	1.10985391
59	MP0006276_abnormal_autonomic_nervous	1.08726968
60	MP0005365_abnormal_bile_salt	1.08429865
61	MP0001501_abnormal_sleep_pattern	1.04681317
62	MP0006035_abnormal_mitochondrial_morpho	1.00514885
63	MP0005360_urolithiasis	0.98647658
64	MP0008775_abnormal_heart_ventricle	0.96944252
65	MP0009697_abnormal_copulation	0.96628041
66	MP0002272_abnormal_nervous_system	0.95922076
67	MP0004381_abnormal_hair_follicle	0.95261635
68	MP0010094_abnormal_chromosome_stability	0.93478956
69	MP0005165_increased_susceptibility_to	0.92345146
70	MP0003638_abnormal_response/metabolism_	0.91176958
71	MP0005085_abnormal_gallbladder_physiolo	0.89875643
72	MP0002398_abnormal_bone_marrow	0.88793617
73	MP0001873_stomach_inflammation	0.88364622
74	MP0002419_abnormal_innate_immunity	0.88195316
75	MP0003786_premature_aging	0.87793767
76	MP0005174_abnormal_tail_pigmentation	0.87734386
77	MP0000716_abnormal_immune_system	0.86486766
78	MP0003866_abnormal_defecation	0.85644677
79	MP0001845_abnormal_inflammatory_respons	0.85222712
80	MP0001929_abnormal_gametogenesis	0.84001340
81	MP0000538_abnormal_urinary_bladder	0.81850235
82	MP0001533_abnormal_skeleton_physiology	0.81639771
83	MP0009333_abnormal_splenocyte_physiolog	0.81112822
84	MP0000689_abnormal_spleen_morphology	0.80531326
85	MP0005332_abnormal_amino_acid	0.80149767
86	MP0005389_reproductive_system_phenotype	0.79502034
87	MP0005379_endocrine/exocrine_gland_phen	0.79099701
88	MP0010368_abnormal_lymphatic_system	0.78724173
89	MP0010386_abnormal_urinary_bladder	0.78470656
90	MP0005645_abnormal_hypothalamus_physiol	0.78371848
91	MP0004142_abnormal_muscle_tone	0.77758586
92	MP0001919_abnormal_reproductive_system	0.76568372
93	MP0001986_abnormal_taste_sensitivity	0.75956466
94	MP0009643_abnormal_urine_homeostasis	0.75767416
95	MP0002405_respiratory_system_inflammati	0.74473374
96	MP0004147_increased_porphyrin_level	0.74060849
97	MP0002429_abnormal_blood_cell	0.73089630
98	MP0005025_abnormal_response_to	0.72754596
99	MP0010329_abnormal_lipoprotein_level	0.72415273
100	MP0005646_abnormal_pituitary_gland	0.72193649

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hypoproteinemia (HP:0003075)	4.38133397
2	Abnormality of alanine metabolism (HP:0010916)	3.61949153
3	Hyperalaninemia (HP:0003348)	3.61949153
4	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	3.61949153
5	Methylmalonic acidemia (HP:0002912)	3.55514436
6	Severe combined immunodeficiency (HP:0004430)	3.25073011
7	Abnormality of the renal cortex (HP:0011035)	3.21086545
8	Congenital, generalized hypertrichosis (HP:0004540)	3.16138479
9	Methylmalonic aciduria (HP:0012120)	3.12542333
10	Elevated erythrocyte sedimentation rate (HP:0003565)	3.07023420
11	Abolished electroretinogram (ERG) (HP:0000550)	3.06050855
12	IgG deficiency (HP:0004315)	3.02119053
13	3-Methylglutaconic aciduria (HP:0003535)	2.97999881
14	Increased serum lactate (HP:0002151)	2.96760077
15	Prostate neoplasm (HP:0100787)	2.94786091
16	Renal cortical cysts (HP:0000803)	2.86149459
17	Increased CSF lactate (HP:0002490)	2.81360955
18	Thyroiditis (HP:0100646)	2.81177336
19	Hepatocellular necrosis (HP:0001404)	2.79123904
20	Mitochondrial inheritance (HP:0001427)	2.78316285
21	Congenital stationary night blindness (HP:0007642)	2.77105694
22	Attenuation of retinal blood vessels (HP:0007843)	2.74296292
23	Decreased central vision (HP:0007663)	2.65139217
24	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.63578779
25	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.60212873
26	Abnormality of T cell number (HP:0011839)	2.58533799
27	T lymphocytopenia (HP:0005403)	2.57591182
28	Hepatic necrosis (HP:0002605)	2.54770444
29	Hypoplasia of the fovea (HP:0007750)	2.54744833
30	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.54744833
31	Stomach cancer (HP:0012126)	2.54646148
32	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.51777889
33	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.51777889
34	Stomatitis (HP:0010280)	2.50207935
35	Pancreatic cysts (HP:0001737)	2.44337025
36	Combined immunodeficiency (HP:0005387)	2.43808832
37	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.42248667
38	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.40881720
39	Acute necrotizing encephalopathy (HP:0006965)	2.40710629
40	Hypoplasia of the uterus (HP:0000013)	2.40678783
41	Abnormality of the prostate (HP:0008775)	2.36384769
42	Hypomagnesemia (HP:0002917)	2.36250224
43	Abnormality of eosinophils (HP:0001879)	2.36208128
44	Progressive inability to walk (HP:0002505)	2.35586498
45	Increased hepatocellular lipid droplets (HP:0006565)	2.29719793
46	True hermaphroditism (HP:0010459)	2.28140643
47	Abnormality of vitamin B metabolism (HP:0004340)	2.28003971
48	Aplasia/hypoplasia of the uterus (HP:0008684)	2.27571881
49	Medial flaring of the eyebrow (HP:0010747)	2.22602831
50	Inability to walk (HP:0002540)	2.21990369
51	Abnormality of the renal medulla (HP:0100957)	2.20938230
52	Abnormality of the pons (HP:0007361)	2.20003673
53	Abnormal mitochondria in muscle tissue (HP:0008316)	2.19241757
54	Hydroxyprolinuria (HP:0003080)	2.16843314
55	Abnormality of proline metabolism (HP:0010907)	2.16843314
56	Abnormality of B cell number (HP:0010975)	2.15776823
57	Lactic acidosis (HP:0003128)	2.15659625
58	Abnormality of T cells (HP:0002843)	2.14273432
59	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.13974922
60	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.13364350
61	Absent/shortened dynein arms (HP:0200106)	2.13364350
62	Lipid accumulation in hepatocytes (HP:0006561)	2.11991154
63	Progressive macrocephaly (HP:0004481)	2.09227251
64	Abnormality of the fovea (HP:0000493)	2.08947862
65	Acute encephalopathy (HP:0006846)	2.08230329
66	Abnormality of serum amino acid levels (HP:0003112)	2.07913017
67	Conical tooth (HP:0000698)	2.07730152
68	Pancreatic fibrosis (HP:0100732)	2.01266785
69	Dicarboxylic aciduria (HP:0003215)	2.00920856
70	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.00920856
71	Progressive microcephaly (HP:0000253)	2.00708409
72	Nephronophthisis (HP:0000090)	1.99545572
73	Eosinophilia (HP:0001880)	1.98416348
74	Abnormality of magnesium homeostasis (HP:0004921)	1.97003629
75	Tubular atrophy (HP:0000092)	1.96571853
76	Bony spicule pigmentary retinopathy (HP:0007737)	1.95123270
77	Exertional dyspnea (HP:0002875)	1.94738713
78	Increased serum pyruvate (HP:0003542)	1.94688986
79	Renal Fanconi syndrome (HP:0001994)	1.94335167
80	Opisthotonus (HP:0002179)	1.93648162
81	Colon cancer (HP:0003003)	1.92084764
82	Type 2 muscle fiber atrophy (HP:0003554)	1.91534183
83	Abnormality of glutamine family amino acid metabolism (HP:0010902)	1.89988037
84	Hypoplasia of the pons (HP:0012110)	1.89976112
85	Petechiae (HP:0000967)	1.89865320
86	B lymphocytopenia (HP:0010976)	1.89343919
87	Constricted visual fields (HP:0001133)	1.88551288
88	Optic disc pallor (HP:0000543)	1.88195037
89	Abnormality of the vocal cords (HP:0008777)	1.85421131
90	Delayed CNS myelination (HP:0002188)	1.84919854
91	Large for gestational age (HP:0001520)	1.84352330
92	Broad-based gait (HP:0002136)	1.80479214
93	Type II lissencephaly (HP:0007260)	1.79118575
94	Goiter (HP:0000853)	1.78714412
95	Poor head control (HP:0002421)	1.77096752
96	Tubulointerstitial nephritis (HP:0001970)	1.75641836
97	Facial diplegia (HP:0001349)	1.75503072
98	Respiratory failure (HP:0002878)	1.73613784
99	Molar tooth sign on MRI (HP:0002419)	1.73460684
100	Abnormality of midbrain morphology (HP:0002418)	1.73460684

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	VRK2	4.05435507
2	TLK1	3.35741999
3	TXK	3.29295879
4	MST4	2.84809012
5	NUAK1	2.84557906
6	ZAK	2.80411393
7	TAOK3	2.44706376
8	MAP4K2	2.30460574
9	VRK1	2.13455137
10	TIE1	2.10264297
11	FRK	2.02110559
12	TSSK6	1.96984608
13	TESK2	1.96672788
14	GRK1	1.92304737
15	MAP3K12	1.81550323
16	BMPR1B	1.80541026
17	PDK2	1.74773402
18	ADRBK2	1.74597455
19	KDR	1.73967775
20	STK39	1.73160884
21	BUB1	1.68136420
22	MAP3K14	1.66380923
23	WNK3	1.47319313
24	MAP2K2	1.46779683
25	NEK1	1.46503260
26	TRIM28	1.45263151
27	OXSR1	1.41621601
28	MYLK	1.33395632
29	IKBKB	1.28582548
30	EIF2AK3	1.28268349
31	EIF2AK1	1.26690896
32	TEC	1.23668809
33	EIF2AK2	1.09018368
34	BMPR2	1.08329007
35	GRK6	1.07576145
36	PIK3CG	1.07066770
37	PLK3	1.02983565
38	INSRR	0.98568590
39	DAPK1	0.96755919
40	WNK4	0.93655882
41	PLK2	0.92089867
42	FES	0.86124707
43	IKBKE	0.82062122
44	PTK2B	0.81994371
45	MKNK2	0.81727458
46	GRK5	0.80666588
47	PINK1	0.78790677
48	PLK4	0.78408805
49	MAPK13	0.76598635
50	BCKDK	0.75870999
51	SYK	0.75292404
52	MAP4K1	0.74219416
53	MAPKAPK3	0.73261360
54	ERBB3	0.72685030
55	ITK	0.72547080
56	KIT	0.71348666
57	SRPK1	0.69639307
58	IGF1R	0.65551212
59	PRKCQ	0.65354276
60	ZAP70	0.63554475
61	TAF1	0.62143231
62	CAMKK2	0.61438829
63	TBK1	0.61245386
64	FER	0.61191765
65	MAPKAPK5	0.55635043
66	BCR	0.51364110
67	MKNK1	0.50935459
68	ADRBK1	0.49911246
69	CSNK1G2	0.49372699
70	PHKG1	0.49311509
71	PHKG2	0.49311509
72	LYN	0.44891449
73	PRKCE	0.44726285
74	CDK8	0.44446094
75	EGFR	0.43112119
76	LCK	0.42013061
77	CCNB1	0.41948280
78	CSNK1G3	0.41310679
79	TGFBR1	0.41112877
80	DYRK2	0.40576133
81	MUSK	0.40114365
82	BRSK2	0.39641559
83	BTK	0.39535778
84	MAP3K4	0.39126369
85	ABL1	0.38354673
86	CSNK1G1	0.38172574
87	RPS6KA5	0.37849591
88	PLK1	0.36236114
89	LIMK1	0.35801548
90	STK10	0.35285164
91	DAPK2	0.34524647
92	RPS6KA4	0.33874975
93	TNIK	0.33700890
94	TRPM7	0.33353162
95	ILK	0.33100229
96	JAK1	0.33007665
97	PRKCI	0.32806669
98	PRKCG	0.32680661
99	STK3	0.31811608
100	MAP2K7	0.29938984

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	3.75924716
2	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.56646579
3	Asthma_Homo sapiens_hsa05310	2.56368061
4	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.48481936
5	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	2.37750160
6	Sulfur metabolism_Homo sapiens_hsa00920	2.35769797
7	Allograft rejection_Homo sapiens_hsa05330	2.27014249
8	Protein export_Homo sapiens_hsa03060	2.22065804
9	Primary immunodeficiency_Homo sapiens_hsa05340	2.16691005
10	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.15403282
11	Graft-versus-host disease_Homo sapiens_hsa05332	2.01986112
12	Oxidative phosphorylation_Homo sapiens_hsa00190	1.99322922
13	Non-homologous end-joining_Homo sapiens_hsa03450	1.95704881
14	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.94861845
15	RNA polymerase_Homo sapiens_hsa03020	1.79292066
16	Phototransduction_Homo sapiens_hsa04744	1.77187905
17	Homologous recombination_Homo sapiens_hsa03440	1.73575903
18	Basal transcription factors_Homo sapiens_hsa03022	1.64058568
19	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.59364637
20	Parkinsons disease_Homo sapiens_hsa05012	1.58263538
21	Type I diabetes mellitus_Homo sapiens_hsa04940	1.57332476
22	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.57161686
23	Fatty acid elongation_Homo sapiens_hsa00062	1.55023395
24	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.54589721
25	Antigen processing and presentation_Homo sapiens_hsa04612	1.46324733
26	Fanconi anemia pathway_Homo sapiens_hsa03460	1.46302624
27	Propanoate metabolism_Homo sapiens_hsa00640	1.41334055
28	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.31870966
29	One carbon pool by folate_Homo sapiens_hsa00670	1.29600298
30	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.20683951
31	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.20209771
32	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.19868405
33	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.18763174
34	Retinol metabolism_Homo sapiens_hsa00830	1.18226587
35	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.16849263
36	Linoleic acid metabolism_Homo sapiens_hsa00591	1.16290760
37	RNA degradation_Homo sapiens_hsa03018	1.15352734
38	Rheumatoid arthritis_Homo sapiens_hsa05323	1.12679555
39	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	1.11883683
40	Nitrogen metabolism_Homo sapiens_hsa00910	1.10144050
41	Peroxisome_Homo sapiens_hsa04146	1.09120932
42	Olfactory transduction_Homo sapiens_hsa04740	1.06907028
43	Mismatch repair_Homo sapiens_hsa03430	1.05554182
44	Tryptophan metabolism_Homo sapiens_hsa00380	1.04184041
45	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.02505807
46	Chemical carcinogenesis_Homo sapiens_hsa05204	1.02099353
47	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.01733867
48	Huntingtons disease_Homo sapiens_hsa05016	1.01298077
49	Regulation of autophagy_Homo sapiens_hsa04140	0.96023847
50	beta-Alanine metabolism_Homo sapiens_hsa00410	0.95845395
51	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.93836937
52	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.93113699
53	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.91638048
54	Glutathione metabolism_Homo sapiens_hsa00480	0.89583215
55	Alzheimers disease_Homo sapiens_hsa05010	0.87887534
56	Butanoate metabolism_Homo sapiens_hsa00650	0.86538810
57	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.84534103
58	Pyrimidine metabolism_Homo sapiens_hsa00240	0.83829717
59	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.83599410
60	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.82754364
61	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.81034390
62	Purine metabolism_Homo sapiens_hsa00230	0.76278599
63	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.75898294
64	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.75720289
65	Ether lipid metabolism_Homo sapiens_hsa00565	0.75419295
66	Viral myocarditis_Homo sapiens_hsa05416	0.75113805
67	Legionellosis_Homo sapiens_hsa05134	0.75032977
68	Nucleotide excision repair_Homo sapiens_hsa03420	0.74017457
69	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.73929119
70	Base excision repair_Homo sapiens_hsa03410	0.70826459
71	Caffeine metabolism_Homo sapiens_hsa00232	0.69539801
72	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.65689699
73	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.62334911
74	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.61952262
75	Collecting duct acid secretion_Homo sapiens_hsa04966	0.61466038
76	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.61111689
77	Pyruvate metabolism_Homo sapiens_hsa00620	0.60138786
78	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.59918892
79	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.58081772
80	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.57825274
81	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.57656800
82	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.56615737
83	Spliceosome_Homo sapiens_hsa03040	0.56370747
84	RNA transport_Homo sapiens_hsa03013	0.56098317
85	Metabolic pathways_Homo sapiens_hsa01100	0.54902575
86	Pancreatic secretion_Homo sapiens_hsa04972	0.52017585
87	Protein digestion and absorption_Homo sapiens_hsa04974	0.51367897
88	Circadian rhythm_Homo sapiens_hsa04710	0.50890271
89	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.50743881
90	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.50188943
91	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.49667293
92	Glycerolipid metabolism_Homo sapiens_hsa00561	0.49644836
93	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.48571545
94	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.47730468
95	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.45325176
96	Fat digestion and absorption_Homo sapiens_hsa04975	0.43988680
97	Herpes simplex infection_Homo sapiens_hsa05168	0.43122052
98	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.41668039
99	Sulfur relay system_Homo sapiens_hsa04122	0.41030818
100	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.37672201

ACTBP7

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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