ACTBP8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.42229727
2cellular response to interleukin-15 (GO:0071350)4.53305770
3cytidine metabolic process (GO:0046087)4.29781213
4cytidine catabolic process (GO:0006216)4.29781213
5cytidine deamination (GO:0009972)4.29781213
6regulation of gonadotropin secretion (GO:0032276)4.08337458
7response to interleukin-15 (GO:0070672)4.07636800
8regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.04089140
9positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.98967371
10positive regulation of T cell mediated cytotoxicity (GO:0001916)3.94249386
11regulation of B cell receptor signaling pathway (GO:0050855)3.91017542
12antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.88850297
13positive regulation of growth hormone secretion (GO:0060124)3.88845884
14positive regulation of interleukin-17 production (GO:0032740)3.88033191
15mast cell activation (GO:0045576)3.78869429
16pyrimidine ribonucleoside catabolic process (GO:0046133)3.77131521
17positive regulation of defense response to virus by host (GO:0002230)3.72344319
18regulation of memory T cell differentiation (GO:0043380)3.71691825
19regulation of T cell mediated cytotoxicity (GO:0001914)3.71121219
20regulation of isotype switching to IgG isotypes (GO:0048302)3.69945409
21negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.67660687
22negative regulation of cell killing (GO:0031342)3.67660687
23proteasome assembly (GO:0043248)3.59000778
24mast cell activation involved in immune response (GO:0002279)3.52554346
25mast cell degranulation (GO:0043303)3.52554346
26negative T cell selection (GO:0043383)3.48566717
27Arp2/3 complex-mediated actin nucleation (GO:0034314)3.42699079
28positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.37254489
29regulation of leukocyte mediated cytotoxicity (GO:0001910)3.36346133
30positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.35404339
31ATP synthesis coupled proton transport (GO:0015986)3.23840324
32energy coupled proton transport, down electrochemical gradient (GO:0015985)3.23840324
33regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.18235971
34neutrophil activation involved in immune response (GO:0002283)3.15629195
35response to interferon-beta (GO:0035456)3.13908358
36positive regulation of T-helper 1 type immune response (GO:0002827)3.13734326
37leukocyte aggregation (GO:0070486)3.11999016
38regulation of activation of Janus kinase activity (GO:0010533)3.10680210
39leukocyte degranulation (GO:0043299)3.10228179
40negative thymic T cell selection (GO:0045060)3.09132888
41regulation of regulatory T cell differentiation (GO:0045589)3.07328617
42RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.06163390
43tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.06163390
44positive regulation of cell killing (GO:0031343)3.06097989
45regulation of cell killing (GO:0031341)3.03841694
46actin nucleation (GO:0045010)3.02704128
47antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.99672505
48positive regulation of alpha-beta T cell proliferation (GO:0046641)2.99229548
49antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.95899970
50molting cycle (GO:0042303)2.95667947
51hair cycle (GO:0042633)2.95667947
52regulation of natural killer cell mediated immunity (GO:0002715)2.93007116
53regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.93007116
54positive regulation of isotype switching (GO:0045830)2.90103790
55neutrophil activation (GO:0042119)2.88968583
56antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.88729582
57antigen processing and presentation of endogenous antigen (GO:0019883)2.88694512
58regulation of defense response to virus by host (GO:0050691)2.88474684
59positive regulation of DNA recombination (GO:0045911)2.87153796
60regulation of alpha-beta T cell proliferation (GO:0046640)2.80462542
61positive regulation of T cell mediated immunity (GO:0002711)2.78646038
62cellular defense response (GO:0006968)2.76852216
63DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.76807930
64regulation of immunoglobulin secretion (GO:0051023)2.76409965
65protein deneddylation (GO:0000338)2.76243028
66positive regulation of gamma-delta T cell activation (GO:0046645)2.73549833
67regulation of T-helper 1 type immune response (GO:0002825)2.73153539
68regulation of cellular amino acid metabolic process (GO:0006521)2.72826887
69negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.71206384
70negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.71047400
71regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.71037983
72tolerance induction (GO:0002507)2.70317201
73signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.69795298
74signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.69795298
75signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.69795298
76regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.68127468
77regulation of B cell differentiation (GO:0045577)2.67281219
78regulation of interleukin-17 production (GO:0032660)2.67035855
79signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.65943100
80intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.65943100
81positive regulation of immunoglobulin mediated immune response (GO:0002891)2.65814487
82positive regulation of B cell mediated immunity (GO:0002714)2.65814487
83positive regulation of adaptive immune response based on somatic recombination of immune receptors b2.64518593
84antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.62933481
85regulation of chronic inflammatory response (GO:0002676)2.62890743
86positive regulation of natural killer cell mediated immunity (GO:0002717)2.61066709
87positive regulation of lymphocyte mediated immunity (GO:0002708)2.58239993
88negative regulation of T-helper cell differentiation (GO:0045623)2.57648861
89negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.57648861
90positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.57144247
91signal transduction involved in DNA damage checkpoint (GO:0072422)2.55029170
92signal transduction involved in DNA integrity checkpoint (GO:0072401)2.55029170
93antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.54813250
94positive regulation of adaptive immune response (GO:0002821)2.52507440
95positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.51634555
96signal transduction involved in cell cycle checkpoint (GO:0072395)2.50369518
97mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.50156807
98regulation of T cell receptor signaling pathway (GO:0050856)2.50035710
99positive thymic T cell selection (GO:0045059)2.49424662
100regulation of T cell mediated immunity (GO:0002709)2.48915942

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.43410032
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.73307747
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.48309031
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.39938508
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.37327610
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.27778730
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.10743461
8IRF8_21731497_ChIP-ChIP_J774_Mouse3.05003616
9ELF1_17652178_ChIP-ChIP_JURKAT_Human2.81044830
10BP1_19119308_ChIP-ChIP_Hs578T_Human2.80636487
11FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.77585364
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.75945376
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.73139316
14NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.68448038
15VDR_23849224_ChIP-Seq_CD4+_Human2.53970015
16SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.53376191
17SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.47130889
18FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.43431378
19STAT4_19710469_ChIP-ChIP_TH1__Mouse2.42404308
20CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.27646389
21MYB_26560356_Chip-Seq_TH2_Human2.26983306
22HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.16951765
23ETS1_20019798_ChIP-Seq_JURKAT_Human2.13730640
24RUNX_20019798_ChIP-Seq_JUKART_Human2.10498842
25RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.03268188
26NOTCH1_21737748_ChIP-Seq_TLL_Human2.03215329
27FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.02617616
28GATA3_26560356_Chip-Seq_TH2_Human2.00676023
29FOXP3_21729870_ChIP-Seq_TREG_Human1.96899892
30SRF_21415370_ChIP-Seq_HL-1_Mouse1.93919021
31LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.88096391
32CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.83825414
33HOXB4_20404135_ChIP-ChIP_EML_Mouse1.75266524
34SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.73796510
35IRF1_19129219_ChIP-ChIP_H3396_Human1.69878854
36EGR1_23403033_ChIP-Seq_LIVER_Mouse1.69522549
37SPI1_23547873_ChIP-Seq_NB4_Human1.69150265
38MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.63908611
39VDR_22108803_ChIP-Seq_LS180_Human1.58498307
40PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.56603217
41CREB1_15753290_ChIP-ChIP_HEK293T_Human1.56591611
42GATA3_27048872_Chip-Seq_THYMUS_Human1.56147955
43ZNF274_21170338_ChIP-Seq_K562_Hela1.53074616
44ELK1_19687146_ChIP-ChIP_HELA_Human1.52896786
45LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.50036440
46EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.46505091
47FLI1_27457419_Chip-Seq_LIVER_Mouse1.44161806
48MYB_26560356_Chip-Seq_TH1_Human1.44111099
49TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.37060129
50E2F4_17652178_ChIP-ChIP_JURKAT_Human1.35294958
51CIITA_25753668_ChIP-Seq_RAJI_Human1.34791268
52STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.34535153
53CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.33153430
54MYC_18940864_ChIP-ChIP_HL60_Human1.32972153
55GATA1_22025678_ChIP-Seq_K562_Human1.31861553
56GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.29082475
57YY1_21170310_ChIP-Seq_MESCs_Mouse1.28773000
58BCL6_27268052_Chip-Seq_Bcells_Human1.26592500
59FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.25731784
60RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.24595127
61MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.23181241
62MYC_18358816_ChIP-ChIP_MESCs_Mouse1.22296893
63EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.21569469
64MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.21520326
65MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.19586243
66EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.18238060
67NANOG_20526341_ChIP-Seq_ESCs_Human1.17294673
68CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.16436711
69GABP_19822575_ChIP-Seq_HepG2_Human1.12723837
70IRF8_27001747_Chip-Seq_BMDM_Mouse1.10776442
71PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.10205313
72PCGF2_27294783_Chip-Seq_ESCs_Mouse1.07652039
73MAF_26560356_Chip-Seq_TH1_Human1.07075976
74UTX_26944678_Chip-Seq_JUKART_Human1.06888813
75TP53_22573176_ChIP-Seq_HFKS_Human1.05317625
76PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.05073230
77P300_27268052_Chip-Seq_Bcells_Human1.04737660
78PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.02427867
79VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.00947688
80YY1_22570637_ChIP-Seq_MALME-3M_Human0.99862798
81SPI1_20517297_ChIP-Seq_HL60_Human0.99647833
82DCP1A_22483619_ChIP-Seq_HELA_Human0.99395133
83TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.99357060
84RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.98523754
85FOXA1_27270436_Chip-Seq_PROSTATE_Human0.97495069
86FOXA1_25329375_ChIP-Seq_VCAP_Human0.97495069
87AR_20517297_ChIP-Seq_VCAP_Human0.96937948
88TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.96927182
89SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.95942930
90FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.95752389
91RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.92425381
92BCOR_27268052_Chip-Seq_Bcells_Human0.92128300
93ELF1_20517297_ChIP-Seq_JURKAT_Human0.91008967
94STAT1_20625510_ChIP-Seq_HELA_Human0.90013367
95CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.89987482
96CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.89935848
97ELK1_22589737_ChIP-Seq_MCF10A_Human0.89802657
98RUNX1_22412390_ChIP-Seq_EML_Mouse0.89354760
99GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.88708595
100ERA_21632823_ChIP-Seq_H3396_Human0.87703401

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002163_abnormal_gland_morphology5.09375809
2MP0005671_abnormal_response_to4.34933262
3MP0001835_abnormal_antigen_presentation4.28741846
4MP0003724_increased_susceptibility_to3.71963119
5MP0005379_endocrine/exocrine_gland_phen2.98274809
6MP0003436_decreased_susceptibility_to2.89289873
7MP0009785_altered_susceptibility_to2.79169697
8MP0005000_abnormal_immune_tolerance2.77260350
9MP0003806_abnormal_nucleotide_metabolis2.76006397
10MP0003763_abnormal_thymus_physiology2.68492012
11MP0000685_abnormal_immune_system2.65897960
12MP0001800_abnormal_humoral_immune2.65146991
13MP0001790_abnormal_immune_system2.55325084
14MP0005387_immune_system_phenotype2.55325084
15MP0002148_abnormal_hypersensitivity_rea2.54265903
16MP0002723_abnormal_immune_serum2.29365062
17MP0002452_abnormal_antigen_presenting2.17474662
18MP0005025_abnormal_response_to2.14853369
19MP0002420_abnormal_adaptive_immunity2.12782581
20MP0001819_abnormal_immune_cell2.11965047
21MP0005084_abnormal_gallbladder_morpholo1.98862093
22MP0009333_abnormal_splenocyte_physiolog1.94127613
23MP0002138_abnormal_hepatobiliary_system1.93403941
24MP0003866_abnormal_defecation1.91168137
25MP0002419_abnormal_innate_immunity1.89236888
26MP0008872_abnormal_physiological_respon1.83777967
27MP0001348_abnormal_lacrimal_gland1.82766853
28MP0002166_altered_tumor_susceptibility1.79400562
29MP0001873_stomach_inflammation1.77554384
30MP0000465_gastrointestinal_hemorrhage1.72442204
31MP0002006_tumorigenesis1.65105526
32MP0009764_decreased_sensitivity_to1.64570319
33MP0010155_abnormal_intestine_physiology1.58797451
34MP0002398_abnormal_bone_marrow1.56808000
35MP0002405_respiratory_system_inflammati1.56576690
36MP0002277_abnormal_respiratory_mucosa1.53712110
37MP0002102_abnormal_ear_morphology1.53532131
38MP0000716_abnormal_immune_system1.52561360
39MP0001533_abnormal_skeleton_physiology1.52038922
40MP0005464_abnormal_platelet_physiology1.47925582
41MP0001845_abnormal_inflammatory_respons1.47319822
42MP0000689_abnormal_spleen_morphology1.45350094
43MP0004147_increased_porphyrin_level1.37372793
44MP0002722_abnormal_immune_system1.32346373
45MP0003786_premature_aging1.30509264
46MP0003878_abnormal_ear_physiology1.30145350
47MP0005377_hearing/vestibular/ear_phenot1.30145350
48MP0005645_abnormal_hypothalamus_physiol1.29037065
49MP0002429_abnormal_blood_cell1.26944352
50MP0000613_abnormal_salivary_gland1.23757619
51MP0003646_muscle_fatigue1.23638450
52MP0001853_heart_inflammation1.21411175
53MP0006082_CNS_inflammation1.20512117
54MP0002132_abnormal_respiratory_system1.20026411
55MP0000703_abnormal_thymus_morphology1.18377527
56MP0008875_abnormal_xenobiotic_pharmacok1.16445584
57MP0002933_joint_inflammation1.13238365
58MP0005075_abnormal_melanosome_morpholog1.12546419
59MP0003300_gastrointestinal_ulcer1.10510929
60MP0004947_skin_inflammation1.09149904
61MP0005167_abnormal_blood-brain_barrier1.04971679
62MP0003195_calcinosis1.01150396
63MP0008469_abnormal_protein_level1.00730166
64MP0004145_abnormal_muscle_electrophysio0.99975193
65MP0001984_abnormal_olfaction0.93219064
66MP0001986_abnormal_taste_sensitivity0.87818071
67MP0008058_abnormal_DNA_repair0.87734279
68MP0006072_abnormal_retinal_apoptosis0.87317088
69MP0003045_fibrosis0.87275730
70MP0006035_abnormal_mitochondrial_morpho0.87259322
71MP0002837_dystrophic_cardiac_calcinosis0.86231795
72MP0008877_abnormal_DNA_methylation0.85452998
73MP0006036_abnormal_mitochondrial_physio0.85406911
74MP0001529_abnormal_vocalization0.83436577
75MP0005310_abnormal_salivary_gland0.81830394
76MP0000647_abnormal_sebaceous_gland0.81003044
77MP0003718_maternal_effect0.77952019
78MP0003638_abnormal_response/metabolism_0.77778049
79MP0002876_abnormal_thyroid_physiology0.74346792
80MP0000372_irregular_coat_pigmentation0.73583888
81MP0009763_increased_sensitivity_to0.72429090
82MP0001765_abnormal_ion_homeostasis0.72210374
83MP0002736_abnormal_nociception_after0.72068811
84MP0001968_abnormal_touch/_nociception0.71828399
85MP0003448_altered_tumor_morphology0.70585065
86MP0001501_abnormal_sleep_pattern0.70211607
87MP0002019_abnormal_tumor_incidence0.69056385
88MP0001663_abnormal_digestive_system0.66798579
89MP0005166_decreased_susceptibility_to0.66773783
90MP0004142_abnormal_muscle_tone0.64106177
91MP0008995_early_reproductive_senescence0.63480637
92MP0005551_abnormal_eye_electrophysiolog0.63294474
93MP0005410_abnormal_fertilization0.61737227
94MP0001905_abnormal_dopamine_level0.60381360
95MP0000639_abnormal_adrenal_gland0.59776671
96MP0005390_skeleton_phenotype0.58261226
97MP0001243_abnormal_dermal_layer0.57881076
98MP0005636_abnormal_mineral_homeostasis0.53912904
99MP0005360_urolithiasis0.53629782
100MP0000858_altered_metastatic_potential0.51630042

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)4.93357449
2Stomatitis (HP:0010280)4.82781383
3IgG deficiency (HP:0004315)4.59959449
4Myositis (HP:0100614)3.75277570
5Severe combined immunodeficiency (HP:0004430)3.56742589
6Retrobulbar optic neuritis (HP:0100654)3.42521500
7Optic neuritis (HP:0100653)3.42521500
8Brittle hair (HP:0002299)3.35322544
9Increased IgM level (HP:0003496)3.34036469
10Orchitis (HP:0100796)3.13939076
11Prostate neoplasm (HP:0100787)3.10370934
12T lymphocytopenia (HP:0005403)2.99519424
13Abnormality of T cells (HP:0002843)2.99378709
143-Methylglutaconic aciduria (HP:0003535)2.92603812
15Acute necrotizing encephalopathy (HP:0006965)2.90485473
16Abnormality of T cell number (HP:0011839)2.87504191
17Abnormality of the prostate (HP:0008775)2.82750131
18Panhypogammaglobulinemia (HP:0003139)2.80263342
19Recurrent fungal infections (HP:0002841)2.78020986
20Combined immunodeficiency (HP:0005387)2.74772695
21Abnormal mitochondria in muscle tissue (HP:0008316)2.72808689
22Mitochondrial inheritance (HP:0001427)2.71571336
23Congenital stationary night blindness (HP:0007642)2.66958555
24Chronic mucocutaneous candidiasis (HP:0002728)2.64765487
25Recurrent cutaneous fungal infections (HP:0011370)2.64765487
26Increased CSF lactate (HP:0002490)2.62257233
27Abnormality of T cell physiology (HP:0011840)2.60457233
28Encephalitis (HP:0002383)2.58516589
29Acute encephalopathy (HP:0006846)2.57564412
30Abolished electroretinogram (ERG) (HP:0000550)2.55812943
31Hypoproteinemia (HP:0003075)2.54689485
32Keratoconjunctivitis (HP:0001096)2.53914871
33Hepatocellular necrosis (HP:0001404)2.44975234
34Keratoconjunctivitis sicca (HP:0001097)2.44634850
35Abnormality of eosinophils (HP:0001879)2.39239205
36Pulmonary infiltrates (HP:0002113)2.38355432
37Pustule (HP:0200039)2.38144053
38Progressive macrocephaly (HP:0004481)2.33830351
39Absent rod-and cone-mediated responses on ERG (HP:0007688)2.33649757
40Hepatic necrosis (HP:0002605)2.30687748
41Congenital, generalized hypertrichosis (HP:0004540)2.30644623
42Decreased electroretinogram (ERG) amplitude (HP:0000654)2.28479536
43Abnormal delayed hypersensitivity skin test (HP:0002963)2.26021671
44Eczematoid dermatitis (HP:0000976)2.25552115
45Abnormal rod and cone electroretinograms (HP:0008323)2.25117040
46Chronic diarrhea (HP:0002028)2.21254672
47Renal cortical cysts (HP:0000803)2.20059533
48Petechiae (HP:0000967)2.19097808
49Gastrointestinal infarctions (HP:0005244)2.15982277
50Vasculitis (HP:0002633)2.15534165
51Increased serum lactate (HP:0002151)2.15404726
52Leukocytosis (HP:0001974)2.15323369
53Pulmonary fibrosis (HP:0002206)2.13763910
54Abnormality of B cell number (HP:0010975)2.12617708
55Aplastic anemia (HP:0001915)2.10220046
56Anorexia (HP:0002039)2.09761698
57Thyroiditis (HP:0100646)2.07018169
58Exertional dyspnea (HP:0002875)2.05869438
59Hypotrichosis (HP:0001006)2.03152746
60Stomach cancer (HP:0012126)2.02052717
61Hemoptysis (HP:0002105)2.01836706
62Mediastinal lymphadenopathy (HP:0100721)2.01121548
63B lymphocytopenia (HP:0010976)1.99586008
64Cleft eyelid (HP:0000625)1.98716293
65IgM deficiency (HP:0002850)1.97527788
66Abnormality of alanine metabolism (HP:0010916)1.97384989
67Hyperalaninemia (HP:0003348)1.97384989
68Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.97384989
69Lactic acidosis (HP:0003128)1.96965319
70Decreased activity of mitochondrial respiratory chain (HP:0008972)1.96167755
71Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.96167755
72Progressive microcephaly (HP:0000253)1.95587885
73Tinnitus (HP:0000360)1.92751578
74Recurrent abscess formation (HP:0002722)1.92589152
75Eosinophilia (HP:0001880)1.91743143
76Meningitis (HP:0001287)1.91272232
77Skin rash (HP:0000988)1.90854950
78Recurrent bacterial skin infections (HP:0005406)1.90683325
79Erythema (HP:0010783)1.89318515
80Recurrent skin infections (HP:0001581)1.88912114
81Hypergammaglobulinemia (HP:0010702)1.87708973
82Joint swelling (HP:0001386)1.87490381
83Arterial thrombosis (HP:0004420)1.87082688
84Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.86204460
85Abnormal protein N-linked glycosylation (HP:0012347)1.86204460
86Abnormal protein glycosylation (HP:0012346)1.86204460
87Abnormal glycosylation (HP:0012345)1.86204460
88Episodic fever (HP:0001954)1.86088105
89Type I transferrin isoform profile (HP:0003642)1.85456269
90Pancytopenia (HP:0001876)1.85185506
91Acute hepatic failure (HP:0006554)1.84998932
92Granulocytopenia (HP:0001913)1.83670635
93Optic disc pallor (HP:0000543)1.83090759
94Cerebral edema (HP:0002181)1.83053817
95Generalized aminoaciduria (HP:0002909)1.82295566
96Abnormality of the renal cortex (HP:0011035)1.81827126
97Attenuation of retinal blood vessels (HP:0007843)1.80377112
98Pancreatic cysts (HP:0001737)1.80240513
99Lipid accumulation in hepatocytes (HP:0006561)1.77280785
100Urticaria (HP:0001025)1.76811818

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK14.65550133
2ZAK4.46713445
3TXK3.81946233
4TESK23.65997604
5VRK23.09123601
6MAP4K12.80979533
7LMTK22.61185675
8TAOK32.57400980
9KDR2.23246261
10VRK12.17024776
11BUB11.97211914
12BCKDK1.92239868
13NUAK11.84640211
14GRK61.83151056
15NEK11.82919493
16RIPK41.64201182
17MST41.55806010
18SYK1.41433176
19BLK1.33603089
20ADRBK21.30656091
21IKBKB1.29179667
22GRK11.28528348
23DAPK11.25727917
24ZAP701.22195575
25TEC1.21883343
26EPHA31.18236582
27MAP3K141.16501111
28TESK11.13282442
29FES1.12850147
30MAP4K21.11494827
31ITK1.10053386
32LIMK11.09005442
33BTK1.07734992
34EPHB11.06892615
35MAP3K121.05442011
36TBK11.01184503
37TIE11.00880817
38BMPR21.00048419
39KIT0.99783993
40MYLK0.99425874
41IKBKE0.99261848
42MAP2K60.98582155
43EIF2AK30.91145492
44LYN0.88737528
45EIF2AK20.88628259
46IRAK40.86366326
47JAK30.85123338
48CDK190.82981634
49MAP2K20.81276626
50TSSK60.80660137
51RPS6KA40.80298875
52PRKG20.80096945
53PTK2B0.79863645
54RPS6KA50.79086976
55GRK50.78530071
56SMG10.78316017
57TAF10.77908731
58CSF1R0.74264728
59CSNK1G30.73719342
60OXSR10.73645493
61MAPKAPK30.73428604
62LCK0.73385062
63EIF2AK10.69648048
64CSK0.68994076
65EPHA20.68488237
66PRKCQ0.67230149
67DAPK20.67228340
68TNK20.66678593
69TRIM280.66296451
70HCK0.66279140
71WNK30.59661729
72ARAF0.59310667
73TYK20.57352056
74NME10.57210281
75SIK30.56908626
76CSNK1A1L0.56686809
77DAPK30.54864674
78AURKA0.53789563
79JAK10.51455516
80STK100.50490659
81GRK70.50249243
82PDK20.49747975
83DYRK20.49355938
84SCYL20.48586439
85PIM10.47197898
86CSNK1G20.46353561
87JAK20.42907800
88MATK0.38781949
89PIM20.38051971
90PHKG10.37172730
91PHKG20.37172730
92MUSK0.36503467
93IGF1R0.36286197
94STK160.35529543
95ADRBK10.35044070
96WNK40.34840246
97INSRR0.34465125
98PINK10.34247403
99CSNK1G10.32564731
100PLK30.32317643

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.15147383
2Primary immunodeficiency_Homo sapiens_hsa053403.72338441
3Allograft rejection_Homo sapiens_hsa053303.11827330
4Graft-versus-host disease_Homo sapiens_hsa053322.91124020
5Autoimmune thyroid disease_Homo sapiens_hsa053202.88081954
6Intestinal immune network for IgA production_Homo sapiens_hsa046722.80451751
7Asthma_Homo sapiens_hsa053102.74256251
8Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.59027335
9Oxidative phosphorylation_Homo sapiens_hsa001902.19934430
10Antigen processing and presentation_Homo sapiens_hsa046122.17194270
11Type I diabetes mellitus_Homo sapiens_hsa049402.12860610
12Systemic lupus erythematosus_Homo sapiens_hsa053222.07697592
13Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.05298277
14Parkinsons disease_Homo sapiens_hsa050122.02946877
15Hematopoietic cell lineage_Homo sapiens_hsa046401.85753082
16Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.75197435
17RNA polymerase_Homo sapiens_hsa030201.73567412
18Mismatch repair_Homo sapiens_hsa034301.56493216
19Protein export_Homo sapiens_hsa030601.55309013
20Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.54860792
21Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.51304619
22Homologous recombination_Homo sapiens_hsa034401.51245815
23T cell receptor signaling pathway_Homo sapiens_hsa046601.49035082
24NF-kappa B signaling pathway_Homo sapiens_hsa040641.45867834
25Viral myocarditis_Homo sapiens_hsa054161.36707049
26Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.34051185
27DNA replication_Homo sapiens_hsa030301.32239595
28Rheumatoid arthritis_Homo sapiens_hsa053231.31286987
29Leishmaniasis_Homo sapiens_hsa051401.26785188
30Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.24532515
31Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.11973608
32Measles_Homo sapiens_hsa051621.09903448
33Shigellosis_Homo sapiens_hsa051311.08536690
34Malaria_Homo sapiens_hsa051441.07891108
35Pyrimidine metabolism_Homo sapiens_hsa002401.06943377
36Huntingtons disease_Homo sapiens_hsa050161.06414554
37Spliceosome_Homo sapiens_hsa030401.01392676
38Regulation of autophagy_Homo sapiens_hsa041401.00976496
39Base excision repair_Homo sapiens_hsa034101.00393905
40SNARE interactions in vesicular transport_Homo sapiens_hsa041300.98531307
41Alzheimers disease_Homo sapiens_hsa050100.96298625
42Fatty acid elongation_Homo sapiens_hsa000620.94836486
43One carbon pool by folate_Homo sapiens_hsa006700.94057642
44Jak-STAT signaling pathway_Homo sapiens_hsa046300.93256826
45Nucleotide excision repair_Homo sapiens_hsa034200.92240753
46NOD-like receptor signaling pathway_Homo sapiens_hsa046210.92101785
47Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.90751275
48Staphylococcus aureus infection_Homo sapiens_hsa051500.90446109
49Basal transcription factors_Homo sapiens_hsa030220.89784448
50alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.89464521
51Herpes simplex infection_Homo sapiens_hsa051680.88472887
52Phototransduction_Homo sapiens_hsa047440.86969494
53Legionellosis_Homo sapiens_hsa051340.86823789
54RNA degradation_Homo sapiens_hsa030180.86038421
55Linoleic acid metabolism_Homo sapiens_hsa005910.82743539
56Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.81929775
57Purine metabolism_Homo sapiens_hsa002300.76495508
58Nitrogen metabolism_Homo sapiens_hsa009100.73536919
59Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.72798186
60Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.72749878
61Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.70317380
62RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.69944492
63Alcoholism_Homo sapiens_hsa050340.68839154
64Epstein-Barr virus infection_Homo sapiens_hsa051690.67980002
65Non-homologous end-joining_Homo sapiens_hsa034500.67917686
66Osteoclast differentiation_Homo sapiens_hsa043800.63813043
67Fanconi anemia pathway_Homo sapiens_hsa034600.62661794
68Ribosome_Homo sapiens_hsa030100.60966437
69African trypanosomiasis_Homo sapiens_hsa051430.60770563
70Selenocompound metabolism_Homo sapiens_hsa004500.60564175
71Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.59561617
72Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.57816721
73Viral carcinogenesis_Homo sapiens_hsa052030.56958555
74Tuberculosis_Homo sapiens_hsa051520.56513763
75Sulfur metabolism_Homo sapiens_hsa009200.56132816
76Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.54432651
77Cysteine and methionine metabolism_Homo sapiens_hsa002700.53555478
78Collecting duct acid secretion_Homo sapiens_hsa049660.53407138
79Caffeine metabolism_Homo sapiens_hsa002320.52947668
80Vibrio cholerae infection_Homo sapiens_hsa051100.51706492
81Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.50958215
82Phagosome_Homo sapiens_hsa041450.50159011
83Pentose phosphate pathway_Homo sapiens_hsa000300.47125243
84Apoptosis_Homo sapiens_hsa042100.46964763
852-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.46745284
86Propanoate metabolism_Homo sapiens_hsa006400.44744704
87Arachidonic acid metabolism_Homo sapiens_hsa005900.44643943
88Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.42792968
89Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.42752863
90Sulfur relay system_Homo sapiens_hsa041220.40853534
91Influenza A_Homo sapiens_hsa051640.40423652
92Transcriptional misregulation in cancer_Homo sapiens_hsa052020.39991523
93RNA transport_Homo sapiens_hsa030130.37817802
94Peroxisome_Homo sapiens_hsa041460.37732357
95Tryptophan metabolism_Homo sapiens_hsa003800.36760062
96Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.36187730
97Salmonella infection_Homo sapiens_hsa051320.35983231
98Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.35297817
99Drug metabolism - other enzymes_Homo sapiens_hsa009830.34349065
100Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.33781605

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