ACTBP9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.26032162
2proteasome assembly (GO:0043248)4.38701824
3cellular response to interleukin-15 (GO:0071350)4.36800358
4regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.23397665
5cytidine metabolic process (GO:0046087)4.14083954
6cytidine catabolic process (GO:0006216)4.14083954
7cytidine deamination (GO:0009972)4.14083954
8regulation of isotype switching to IgG isotypes (GO:0048302)3.98889010
9Arp2/3 complex-mediated actin nucleation (GO:0034314)3.86392372
10protein neddylation (GO:0045116)3.83692753
11pyrimidine ribonucleoside catabolic process (GO:0046133)3.69538106
12response to interleukin-15 (GO:0070672)3.48063091
13actin nucleation (GO:0045010)3.42943039
14platelet dense granule organization (GO:0060155)3.37319633
15regulation of cellular amino acid metabolic process (GO:0006521)3.34877080
16regulation of chronic inflammatory response (GO:0002676)3.34803505
17positive regulation of T cell mediated cytotoxicity (GO:0001916)3.26647042
18metallo-sulfur cluster assembly (GO:0031163)3.24354275
19iron-sulfur cluster assembly (GO:0016226)3.24354275
20positive regulation of alpha-beta T cell proliferation (GO:0046641)3.24299366
21energy coupled proton transport, down electrochemical gradient (GO:0015985)3.22688440
22ATP synthesis coupled proton transport (GO:0015986)3.22688440
23DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.22089250
24regulation of immunoglobulin secretion (GO:0051023)3.20855871
25positive regulation of defense response to virus by host (GO:0002230)3.20024756
26negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.16454344
27tolerance induction (GO:0002507)3.15008796
28signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.13341280
29signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.13341280
30signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.13341280
31intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.09688351
32signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.09688351
33regulation of B cell receptor signaling pathway (GO:0050855)3.06154951
34regulation of regulatory T cell differentiation (GO:0045589)3.06126438
35antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.03447717
36positive regulation of T-helper 1 type immune response (GO:0002827)3.02101085
37mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.01480544
38DNA catabolic process, exonucleolytic (GO:0000738)2.99898113
39positive regulation of B cell mediated immunity (GO:0002714)2.99190549
40positive regulation of immunoglobulin mediated immune response (GO:0002891)2.99190549
41positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.98431422
42positive regulation of interleukin-8 secretion (GO:2000484)2.98012373
43positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.96938479
44regulation of T cell mediated cytotoxicity (GO:0001914)2.96829330
45signal transduction involved in DNA damage checkpoint (GO:0072422)2.96114402
46signal transduction involved in DNA integrity checkpoint (GO:0072401)2.96114402
47signal transduction involved in cell cycle checkpoint (GO:0072395)2.95232928
48antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.93741042
49positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.91785674
50mast cell activation (GO:0045576)2.91747233
51negative T cell selection (GO:0043383)2.90864962
52regulation of alpha-beta T cell proliferation (GO:0046640)2.89956079
53regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.86614092
54positive regulation of isotype switching (GO:0045830)2.85276642
55protein deneddylation (GO:0000338)2.85232572
56cullin deneddylation (GO:0010388)2.83269990
57L-fucose catabolic process (GO:0042355)2.80978900
58fucose catabolic process (GO:0019317)2.80978900
59L-fucose metabolic process (GO:0042354)2.80978900
60antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.80336424
61positive regulation of cell killing (GO:0031343)2.80315610
62regulation of T cell receptor signaling pathway (GO:0050856)2.78503220
63regulation of leukocyte mediated cytotoxicity (GO:0001910)2.76386910
64T cell differentiation involved in immune response (GO:0002292)2.75227576
65alpha-beta T cell differentiation involved in immune response (GO:0002293)2.75227576
66alpha-beta T cell activation involved in immune response (GO:0002287)2.75227576
67negative regulation of ligase activity (GO:0051352)2.75039537
68negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.75039537
69positive regulation of DNA recombination (GO:0045911)2.72450426
70positive regulation of immunoglobulin production (GO:0002639)2.71546064
71regulation of defense response to virus by host (GO:0050691)2.71306538
72regulation of interleukin-8 secretion (GO:2000482)2.71281123
73regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.70372957
74nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.67928159
75antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.66690734
76negative thymic T cell selection (GO:0045060)2.66490533
77positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.64308685
78exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.63763179
79regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.63551822
80tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.63110715
81RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.63110715
82response to interferon-beta (GO:0035456)2.62268031
83DNA double-strand break processing (GO:0000729)2.61242780
84mast cell activation involved in immune response (GO:0002279)2.61205873
85mast cell degranulation (GO:0043303)2.61205873
86positive regulation of protein homodimerization activity (GO:0090073)2.60074385
87RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.59984000
88regulation of cell killing (GO:0031341)2.59710437
89CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.59332227
90T-helper cell differentiation (GO:0042093)2.59332227
91positive T cell selection (GO:0043368)2.57189968
92positive regulation of adaptive immune response based on somatic recombination of immune receptors b2.57011162
93B cell mediated immunity (GO:0019724)2.55703063
94adenosine metabolic process (GO:0046085)2.55394248
95negative regulation of mast cell activation (GO:0033004)2.53799328
96negative regulation of heart rate (GO:0010459)2.52927259
97positive thymic T cell selection (GO:0045059)2.51678224
98immunoglobulin mediated immune response (GO:0016064)2.50464807
99positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.50413769
100water-soluble vitamin biosynthetic process (GO:0042364)2.48857869

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.45446427
2ELF1_17652178_ChIP-ChIP_JURKAT_Human4.03625957
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.98566310
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.88180681
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.51837728
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.23539907
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.04716288
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.89526797
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.85808073
10VDR_23849224_ChIP-Seq_CD4+_Human2.82010956
11BP1_19119308_ChIP-ChIP_Hs578T_Human2.78275790
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.75771270
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.69642756
14SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.67060305
15CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.64781740
16FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.52762942
17STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.46715945
18IRF8_21731497_ChIP-ChIP_J774_Mouse2.40237746
19FLI1_27457419_Chip-Seq_LIVER_Mouse2.34472755
20ETS1_20019798_ChIP-Seq_JURKAT_Human2.33335942
21FOXP3_21729870_ChIP-Seq_TREG_Human2.03534866
22NOTCH1_21737748_ChIP-Seq_TLL_Human2.00599503
23CREB1_15753290_ChIP-ChIP_HEK293T_Human2.00024913
24MYB_26560356_Chip-Seq_TH2_Human1.98416423
25SRF_21415370_ChIP-Seq_HL-1_Mouse1.97431154
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.95357539
27ZNF274_21170338_ChIP-Seq_K562_Hela1.88979388
28VDR_22108803_ChIP-Seq_LS180_Human1.88851064
29ELK1_19687146_ChIP-ChIP_HELA_Human1.85456775
30SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.82548342
31PCGF2_27294783_Chip-Seq_ESCs_Mouse1.81024288
32GATA3_26560356_Chip-Seq_TH2_Human1.79940182
33PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.69644622
34STAT4_19710469_ChIP-ChIP_TH1__Mouse1.67799604
35FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.60214291
36RUNX_20019798_ChIP-Seq_JUKART_Human1.54635068
37PCGF2_27294783_Chip-Seq_NPCs_Mouse1.53889951
38HOXB4_20404135_ChIP-ChIP_EML_Mouse1.52562886
39SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.52183030
40IRF1_19129219_ChIP-ChIP_H3396_Human1.49433841
41LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.48536635
42CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.39470244
43RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.36450121
44FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.34944812
45CIITA_25753668_ChIP-Seq_RAJI_Human1.34939364
46SPI1_23547873_ChIP-Seq_NB4_Human1.33135835
47MYC_18940864_ChIP-ChIP_HL60_Human1.29782893
48EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.28386765
49PADI4_21655091_ChIP-ChIP_MCF-7_Human1.27486972
50SUZ12_27294783_Chip-Seq_NPCs_Mouse1.27197276
51NFE2_27457419_Chip-Seq_LIVER_Mouse1.26857800
52GATA3_27048872_Chip-Seq_THYMUS_Human1.24141198
53EGR1_23403033_ChIP-Seq_LIVER_Mouse1.23870308
54YY1_21170310_ChIP-Seq_MESCs_Mouse1.21271082
55MYB_26560356_Chip-Seq_TH1_Human1.21223018
56MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.20320006
57AR_20517297_ChIP-Seq_VCAP_Human1.20012719
58DCP1A_22483619_ChIP-Seq_HELA_Human1.19829022
59MYC_18358816_ChIP-ChIP_MESCs_Mouse1.19807328
60FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17536528
61CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.16997927
62TP53_22573176_ChIP-Seq_HFKS_Human1.16025410
63GABP_19822575_ChIP-Seq_HepG2_Human1.15259112
64E2F4_17652178_ChIP-ChIP_JURKAT_Human1.14771120
65FOXA1_27270436_Chip-Seq_PROSTATE_Human1.14292610
66FOXA1_25329375_ChIP-Seq_VCAP_Human1.14292610
67ELK1_22589737_ChIP-Seq_MCF10A_Human1.13784839
68PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.13154085
69PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12801925
70PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.11462623
71EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.07814385
72STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.06796300
73NANOG_20526341_ChIP-Seq_ESCs_Human1.06734666
74LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.04190723
75NCOR_22424771_ChIP-Seq_293T_Human1.01073464
76TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.00654274
77TAF2_19829295_ChIP-Seq_ESCs_Human1.00428028
78EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.99606061
79TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.98920480
80MYC_18555785_ChIP-Seq_MESCs_Mouse0.97642724
81FOXH1_21741376_ChIP-Seq_EPCs_Human0.97341928
82MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.96630793
83EZH2_27294783_Chip-Seq_NPCs_Mouse0.96462103
84E2F1_18555785_ChIP-Seq_MESCs_Mouse0.96168362
85HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.94317053
86HOXB7_26014856_ChIP-Seq_BT474_Human0.93495503
87EWS_26573619_Chip-Seq_HEK293_Human0.93022107
88GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.92253194
89MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.91979915
90GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.90985493
91GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.90170412
92IGF1R_20145208_ChIP-Seq_DFB_Human0.89866802
93GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.89741271
94PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.89573310
95FOXA1_21572438_ChIP-Seq_LNCaP_Human0.89359981
96CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.89229897
97RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.88840746
98SOX2_19829295_ChIP-Seq_ESCs_Human0.88752040
99NANOG_19829295_ChIP-Seq_ESCs_Human0.88752040
100RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.84162962

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to5.12235122
2MP0001835_abnormal_antigen_presentation4.54272593
3MP0000685_abnormal_immune_system2.91775468
4MP0001800_abnormal_humoral_immune2.76952693
5MP0001873_stomach_inflammation2.66991098
6MP0005387_immune_system_phenotype2.66096012
7MP0001790_abnormal_immune_system2.66096012
8MP0009785_altered_susceptibility_to2.65549997
9MP0005000_abnormal_immune_tolerance2.63940793
10MP0003806_abnormal_nucleotide_metabolis2.63669950
11MP0002148_abnormal_hypersensitivity_rea2.57087842
12MP0003724_increased_susceptibility_to2.48974687
13MP0003763_abnormal_thymus_physiology2.32458285
14MP0002166_altered_tumor_susceptibility2.32106039
15MP0002723_abnormal_immune_serum2.26016731
16MP0002006_tumorigenesis2.13285379
17MP0002452_abnormal_antigen_presenting2.08136716
18MP0003436_decreased_susceptibility_to2.07938896
19MP0005084_abnormal_gallbladder_morpholo2.07794892
20MP0010155_abnormal_intestine_physiology2.06265443
21MP0002420_abnormal_adaptive_immunity2.00438537
22MP0001819_abnormal_immune_cell1.99939453
23MP0009333_abnormal_splenocyte_physiolog1.99455620
24MP0005025_abnormal_response_to1.90122317
25MP0008872_abnormal_physiological_respon1.87994572
26MP0000465_gastrointestinal_hemorrhage1.82573101
27MP0004147_increased_porphyrin_level1.77843683
28MP0009764_decreased_sensitivity_to1.75674872
29MP0003866_abnormal_defecation1.75275724
30MP0006072_abnormal_retinal_apoptosis1.72566119
31MP0005645_abnormal_hypothalamus_physiol1.69707927
32MP0002138_abnormal_hepatobiliary_system1.69219641
33MP0008875_abnormal_xenobiotic_pharmacok1.65387510
34MP0003195_calcinosis1.63388569
35MP0001845_abnormal_inflammatory_respons1.52379933
36MP0005075_abnormal_melanosome_morpholog1.49429017
37MP0000716_abnormal_immune_system1.45008670
38MP0002398_abnormal_bone_marrow1.42776866
39MP0005085_abnormal_gallbladder_physiolo1.40745149
40MP0002419_abnormal_innate_immunity1.40416187
41MP0004145_abnormal_muscle_electrophysio1.39400719
42MP0005360_urolithiasis1.35404488
43MP0006036_abnormal_mitochondrial_physio1.35035910
44MP0000689_abnormal_spleen_morphology1.33789117
45MP0002933_joint_inflammation1.31582632
46MP0001853_heart_inflammation1.29356557
47MP0002405_respiratory_system_inflammati1.28674378
48MP0005167_abnormal_blood-brain_barrier1.24507206
49MP0001501_abnormal_sleep_pattern1.24118409
50MP0002254_reproductive_system_inflammat1.21784211
51MP0003718_maternal_effect1.20829921
52MP0002429_abnormal_blood_cell1.18472530
53MP0002722_abnormal_immune_system1.17162522
54MP0003693_abnormal_embryo_hatching1.16666005
55MP0006082_CNS_inflammation1.15571217
56MP0001533_abnormal_skeleton_physiology1.13334707
57MP0004782_abnormal_surfactant_physiolog1.13053712
58MP0005464_abnormal_platelet_physiology1.10029562
59MP0005365_abnormal_bile_salt1.10001571
60MP0008877_abnormal_DNA_methylation1.08934331
61MP0008469_abnormal_protein_level1.04219379
62MP0001986_abnormal_taste_sensitivity1.03853580
63MP0003252_abnormal_bile_duct1.02323680
64MP0000372_irregular_coat_pigmentation1.01989161
65MP0000703_abnormal_thymus_morphology1.00913586
66MP0003011_delayed_dark_adaptation0.99891524
67MP0003186_abnormal_redox_activity0.99653221
68MP0002736_abnormal_nociception_after0.99433973
69MP0008058_abnormal_DNA_repair0.98866098
70MP0005253_abnormal_eye_physiology0.97822560
71MP0006035_abnormal_mitochondrial_morpho0.96123473
72MP0001663_abnormal_digestive_system0.95742090
73MP0002277_abnormal_respiratory_mucosa0.94811770
74MP0005166_decreased_susceptibility_to0.91037593
75MP0001968_abnormal_touch/_nociception0.90546186
76MP0003448_altered_tumor_morphology0.90018047
77MP0006276_abnormal_autonomic_nervous0.89915736
78MP0005551_abnormal_eye_electrophysiolog0.87248380
79MP0001529_abnormal_vocalization0.86883239
80MP0001905_abnormal_dopamine_level0.85940484
81MP0003786_premature_aging0.84286377
82MP0002102_abnormal_ear_morphology0.83841087
83MP0005332_abnormal_amino_acid0.82695729
84MP0001188_hyperpigmentation0.81168975
85MP0009763_increased_sensitivity_to0.80777377
86MP0004947_skin_inflammation0.79684603
87MP0001764_abnormal_homeostasis0.78728597
88MP0003880_abnormal_central_pattern0.78361772
89MP0002019_abnormal_tumor_incidence0.76097239
90MP0003646_muscle_fatigue0.74711898
91MP0004142_abnormal_muscle_tone0.74109248
92MP0002876_abnormal_thyroid_physiology0.71229323
93MP0009765_abnormal_xenobiotic_induced0.69935923
94MP0005310_abnormal_salivary_gland0.68258231
95MP0004957_abnormal_blastocyst_morpholog0.66023304
96MP0001919_abnormal_reproductive_system0.64496997
97MP0000015_abnormal_ear_pigmentation0.61468512
98MP0003303_peritoneal_inflammation0.60432371
99MP0005410_abnormal_fertilization0.59654940
100MP0003950_abnormal_plasma_membrane0.58949041

Predicted human phenotypes

RankGene SetZ-score
1IgG deficiency (HP:0004315)4.93416643
2Elevated erythrocyte sedimentation rate (HP:0003565)4.68785662
3Stomatitis (HP:0010280)4.63951585
43-Methylglutaconic aciduria (HP:0003535)4.09891629
5Increased IgM level (HP:0003496)3.71718251
6Hypoproteinemia (HP:0003075)3.30457419
7Mitochondrial inheritance (HP:0001427)3.23050303
8Hepatocellular necrosis (HP:0001404)3.14573980
9Severe combined immunodeficiency (HP:0004430)3.10636993
10Chronic diarrhea (HP:0002028)3.00962879
11Increased CSF lactate (HP:0002490)2.99049758
12Hepatic necrosis (HP:0002605)2.95827014
13Increased hepatocellular lipid droplets (HP:0006565)2.95582308
14Acute necrotizing encephalopathy (HP:0006965)2.95135481
15Congenital stationary night blindness (HP:0007642)2.85051951
16Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.82339053
17Abnormality of the prostate (HP:0008775)2.82237622
18Increased serum lactate (HP:0002151)2.80696685
19Lipid accumulation in hepatocytes (HP:0006561)2.71348474
20Abnormality of T cell number (HP:0011839)2.69083043
21Acute encephalopathy (HP:0006846)2.68919248
22T lymphocytopenia (HP:0005403)2.68090092
23Abnormal mitochondria in muscle tissue (HP:0008316)2.66546376
24Abnormality of T cells (HP:0002843)2.61693692
25Abnormality of eosinophils (HP:0001879)2.60935814
26Abolished electroretinogram (ERG) (HP:0000550)2.58233293
27Exertional dyspnea (HP:0002875)2.55131278
28Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.55114215
29Increased intramyocellular lipid droplets (HP:0012240)2.53365723
30Congenital, generalized hypertrichosis (HP:0004540)2.51357436
31Myositis (HP:0100614)2.45345259
32Recurrent cutaneous fungal infections (HP:0011370)2.44778073
33Chronic mucocutaneous candidiasis (HP:0002728)2.44778073
34Lactic acidosis (HP:0003128)2.44443355
35Progressive macrocephaly (HP:0004481)2.42369281
36Abnormality of T cell physiology (HP:0011840)2.41793431
37Thyroiditis (HP:0100646)2.36788103
38Renal Fanconi syndrome (HP:0001994)2.33752689
39Combined immunodeficiency (HP:0005387)2.33136864
40Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.29059922
41Abnormality of alanine metabolism (HP:0010916)2.29059922
42Hyperalaninemia (HP:0003348)2.29059922
43IgM deficiency (HP:0002850)2.27708719
44Absent rod-and cone-mediated responses on ERG (HP:0007688)2.27110623
45Decreased electroretinogram (ERG) amplitude (HP:0000654)2.26857433
46Pulmonary infiltrates (HP:0002113)2.24933556
47Cerebral edema (HP:0002181)2.24285075
48Encephalitis (HP:0002383)2.24129258
49Pustule (HP:0200039)2.22595454
50Eosinophilia (HP:0001880)2.20850387
51Cerebral hypomyelination (HP:0006808)2.20263210
52Prostate neoplasm (HP:0100787)2.16605044
53Panhypogammaglobulinemia (HP:0003139)2.16560765
54Decreased activity of mitochondrial respiratory chain (HP:0008972)2.15094460
55Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.15094460
56Type I transferrin isoform profile (HP:0003642)2.14007711
57Pancreatic cysts (HP:0001737)2.13280142
58Abnormality of B cell number (HP:0010975)2.13207358
59Increased muscle lipid content (HP:0009058)2.09270515
60Recurrent bronchitis (HP:0002837)2.09227141
61Optic neuritis (HP:0100653)2.07866791
62Retrobulbar optic neuritis (HP:0100654)2.07866791
63Abnormality of aspartate family amino acid metabolism (HP:0010899)2.07515840
64Stomach cancer (HP:0012126)2.06143566
65Cerebral palsy (HP:0100021)2.05798335
66Abnormal rod and cone electroretinograms (HP:0008323)2.05277750
67IgA deficiency (HP:0002720)2.05274283
68Conical tooth (HP:0000698)2.04866783
69Hemoptysis (HP:0002105)2.04449050
70Lethargy (HP:0001254)1.99373665
71Recurrent fungal infections (HP:0002841)1.97022025
72Vasculitis (HP:0002633)1.95061983
73Abnormality of the pons (HP:0007361)1.93687946
74Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.91551369
75Abnormal protein N-linked glycosylation (HP:0012347)1.91551369
76Abnormal protein glycosylation (HP:0012346)1.91551369
77Abnormal glycosylation (HP:0012345)1.91551369
78Abnormality of serum amino acid levels (HP:0003112)1.89359951
79Opisthotonus (HP:0002179)1.89107703
80Pulmonary fibrosis (HP:0002206)1.87212384
81Glycosuria (HP:0003076)1.87081713
82Abnormality of urine glucose concentration (HP:0011016)1.87081713
83Joint swelling (HP:0001386)1.86674850
84Optic disc pallor (HP:0000543)1.85382338
85Molar tooth sign on MRI (HP:0002419)1.85144731
86Abnormality of midbrain morphology (HP:0002418)1.85144731
87Abnormal delayed hypersensitivity skin test (HP:0002963)1.82896440
88Dicarboxylic aciduria (HP:0003215)1.82081187
89Abnormality of dicarboxylic acid metabolism (HP:0010995)1.82081187
90Agammaglobulinemia (HP:0004432)1.80983627
91Decreased central vision (HP:0007663)1.80103552
92Facial diplegia (HP:0001349)1.79806266
93Abnormality of glutamine family amino acid metabolism (HP:0010902)1.78369401
94Lissencephaly (HP:0001339)1.76734197
95Constricted visual fields (HP:0001133)1.76633936
96Leukocytosis (HP:0001974)1.76260953
97Respiratory failure (HP:0002878)1.76123276
98Granulocytopenia (HP:0001913)1.75423728
99Hypoplasia of the pons (HP:0012110)1.75046454
100Anorexia (HP:0002039)1.74187650

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK23.42949352
2TLK13.26673790
3TXK3.24004398
4BCKDK3.09100434
5TSSK62.67549464
6TESK22.53897703
7ZAK2.50067809
8MAP4K22.32371838
9MAP4K12.26423451
10TIE12.18570387
11EIF2AK32.18305243
12NUAK12.14835123
13MAP3K122.12793303
14NEK12.09084207
15ADRBK22.08267381
16MST42.08022636
17GRK12.04680946
18TRIM282.00997486
19FES1.92100122
20KDR1.89942634
21VRK11.82671718
22MUSK1.76543492
23TEC1.69425581
24TAOK31.60795975
25GRK61.57952389
26MAPKAPK31.54294276
27DAPK11.53144986
28MYLK1.44385969
29ITK1.42848836
30IKBKB1.40167829
31EIF2AK11.38808834
32BUB11.24680887
33KIT1.22380803
34SYK1.21584179
35SRPK11.17298460
36BTK1.15256148
37NME11.10421058
38LIMK11.08679362
39IKBKE1.07670438
40SIK31.05961229
41BMPR21.04942842
42TESK11.02284353
43PINK11.00487020
44PDK21.00133268
45MAP3K140.95013062
46TBK10.89611313
47CDK190.88664078
48LCK0.87791395
49CCNB10.82289040
50LYN0.82057422
51JAK30.80815715
52OXSR10.79804149
53CSNK1G30.77541201
54CSK0.76593351
55PLK30.75606546
56EIF2AK20.75565237
57BCR0.74318181
58WNK30.72680429
59MAP2K20.72093479
60MATK0.69037149
61IRAK40.66791556
62CSF1R0.65076759
63RPS6KA50.64261317
64IGF1R0.59827370
65DYRK20.58709870
66CSNK1G20.58375344
67CSNK1A1L0.58103968
68PRKCQ0.58078064
69ZAP700.55151428
70PIK3CG0.54409692
71HCK0.53849784
72CAMKK20.52127539
73MKNK10.51138787
74RIPK40.49741103
75RPS6KA40.48958030
76PBK0.48168162
77FRK0.48138865
78CSNK1G10.46974846
79ERBB30.46209957
80MAPKAPK50.44068457
81PLK20.41538684
82MAPK130.40959142
83PASK0.38173525
84GRK50.36272795
85JAK10.35941334
86CSNK2A10.35524466
87STK160.33317783
88EPHA30.33012082
89PRKCE0.32722802
90DAPK30.31962280
91ACVR1B0.30403586
92EGFR0.30046291
93ILK0.29845141
94TYK20.29832157
95PIM10.28780751
96INSRR0.28431758
97PLK40.27969730
98ABL10.27357565
99FER0.26974382
100CDK80.25950114

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.08748839
2Asthma_Homo sapiens_hsa053103.80767546
3Allograft rejection_Homo sapiens_hsa053303.73963421
4Intestinal immune network for IgA production_Homo sapiens_hsa046723.52357537
5Autoimmune thyroid disease_Homo sapiens_hsa053203.40025157
6Graft-versus-host disease_Homo sapiens_hsa053323.15409884
7Primary immunodeficiency_Homo sapiens_hsa053402.83543901
8Type I diabetes mellitus_Homo sapiens_hsa049402.61637245
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.49981301
10Antigen processing and presentation_Homo sapiens_hsa046122.13688465
11Protein export_Homo sapiens_hsa030602.13152590
12Oxidative phosphorylation_Homo sapiens_hsa001902.10280180
13Parkinsons disease_Homo sapiens_hsa050121.82527262
14Sulfur metabolism_Homo sapiens_hsa009201.54319949
15Viral myocarditis_Homo sapiens_hsa054161.54114430
16Rheumatoid arthritis_Homo sapiens_hsa053231.51862915
17Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.47538822
18Hematopoietic cell lineage_Homo sapiens_hsa046401.46233018
19RNA polymerase_Homo sapiens_hsa030201.41477248
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.38794558
21Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.38589800
22alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.27785473
23Linoleic acid metabolism_Homo sapiens_hsa005911.27213307
24Propanoate metabolism_Homo sapiens_hsa006401.14593640
25Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.11933778
26Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.10822479
27One carbon pool by folate_Homo sapiens_hsa006701.07057456
28Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.03514447
29Fat digestion and absorption_Homo sapiens_hsa049751.02517540
30Non-homologous end-joining_Homo sapiens_hsa034501.01744790
31RNA degradation_Homo sapiens_hsa030181.00679306
32Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.98132517
33Cyanoamino acid metabolism_Homo sapiens_hsa004600.97256144
34Systemic lupus erythematosus_Homo sapiens_hsa053220.97116664
35Fatty acid elongation_Homo sapiens_hsa000620.97101758
36Huntingtons disease_Homo sapiens_hsa050160.96597870
37Sulfur relay system_Homo sapiens_hsa041220.96469992
38Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.96241350
39T cell receptor signaling pathway_Homo sapiens_hsa046600.95228452
40Tryptophan metabolism_Homo sapiens_hsa003800.93056855
41Homologous recombination_Homo sapiens_hsa034400.91149617
42Alzheimers disease_Homo sapiens_hsa050100.90934535
43Regulation of autophagy_Homo sapiens_hsa041400.90866515
44Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.90150990
45Spliceosome_Homo sapiens_hsa030400.89868308
46NF-kappa B signaling pathway_Homo sapiens_hsa040640.89529848
47Caffeine metabolism_Homo sapiens_hsa002320.88632604
48Leishmaniasis_Homo sapiens_hsa051400.86592446
49Phototransduction_Homo sapiens_hsa047440.86336438
50Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.84664037
51Staphylococcus aureus infection_Homo sapiens_hsa051500.80897476
52Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.80103599
53Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.79792912
54Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.79125000
55Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.78456289
56Butanoate metabolism_Homo sapiens_hsa006500.77036499
57Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.75562271
58Basal transcription factors_Homo sapiens_hsa030220.73159667
59Peroxisome_Homo sapiens_hsa041460.72466591
60Purine metabolism_Homo sapiens_hsa002300.70367952
61Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.69520211
62Arachidonic acid metabolism_Homo sapiens_hsa005900.67311689
63Pyrimidine metabolism_Homo sapiens_hsa002400.67149601
64Measles_Homo sapiens_hsa051620.66882765
65Mismatch repair_Homo sapiens_hsa034300.66504128
66Herpes simplex infection_Homo sapiens_hsa051680.65482650
67Shigellosis_Homo sapiens_hsa051310.65177763
68Chemical carcinogenesis_Homo sapiens_hsa052040.65141680
69Nitrogen metabolism_Homo sapiens_hsa009100.60355026
70Ether lipid metabolism_Homo sapiens_hsa005650.59991356
71Legionellosis_Homo sapiens_hsa051340.59427450
72Vitamin digestion and absorption_Homo sapiens_hsa049770.59082116
73Fanconi anemia pathway_Homo sapiens_hsa034600.58947566
74NOD-like receptor signaling pathway_Homo sapiens_hsa046210.58382352
75RNA transport_Homo sapiens_hsa030130.58006091
762-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.57952477
77Base excision repair_Homo sapiens_hsa034100.57866533
78Cysteine and methionine metabolism_Homo sapiens_hsa002700.56966858
79Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.52362674
80Epstein-Barr virus infection_Homo sapiens_hsa051690.51198506
81Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.50286936
82Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.47928806
83Collecting duct acid secretion_Homo sapiens_hsa049660.47816910
84Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.47543123
85Ribosome_Homo sapiens_hsa030100.47508890
86Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.47481302
87Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.46998296
88Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.46968180
89Biosynthesis of amino acids_Homo sapiens_hsa012300.46272369
90SNARE interactions in vesicular transport_Homo sapiens_hsa041300.45142984
91Primary bile acid biosynthesis_Homo sapiens_hsa001200.42701870
92Nucleotide excision repair_Homo sapiens_hsa034200.40461793
93Metabolic pathways_Homo sapiens_hsa011000.39698803
94Jak-STAT signaling pathway_Homo sapiens_hsa046300.38299485
95Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.37613514
96Drug metabolism - other enzymes_Homo sapiens_hsa009830.37137423
97Glutathione metabolism_Homo sapiens_hsa004800.34375708
98Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.33033592
99Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.32925061
100DNA replication_Homo sapiens_hsa030300.32522171

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »