ACTC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Actins are highly conserved proteins that are involved in various types of cell motility. Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to four others. The protein encoded by this gene belongs to the actin family which is comprised of three main groups of actin isoforms, alpha, beta, and gamma. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. Defects in this gene have been associated with idiopathic dilated cardiomyopathy (IDC) and familial hypertrophic cardiomyopathy (FHC). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* muscle filament sliding (GO:0030049)9.20487722
2* actin-myosin filament sliding (GO:0033275)9.20487722
3muscle cell cellular homeostasis (GO:0046716)9.16139286
4sarcomere organization (GO:0045214)9.10915464
5* cardiac myofibril assembly (GO:0055003)9.04099015
6* actin-mediated cell contraction (GO:0070252)7.75258194
7* myofibril assembly (GO:0030239)7.67750511
8negative regulation of cardiac muscle cell apoptotic process (GO:0010667)7.61892338
9* cardiac muscle tissue morphogenesis (GO:0055008)7.58605666
10cardiac muscle cell development (GO:0055013)7.48219857
11negative regulation of nitric-oxide synthase activity (GO:0051001)7.47664180
12ventricular cardiac muscle tissue morphogenesis (GO:0055010)7.41878127
13cardiac muscle hypertrophy (GO:0003300)7.28567857
14* cardiac muscle contraction (GO:0060048)7.19708523
15cardiac cell development (GO:0055006)7.07376038
16negative regulation of muscle hypertrophy (GO:0014741)6.89932034
17striated muscle hypertrophy (GO:0014897)6.86042868
18negative regulation of potassium ion transmembrane transporter activity (GO:1901017)6.81841168
19striated muscle atrophy (GO:0014891)6.75313019
20* muscle tissue morphogenesis (GO:0060415)6.75150693
21negative regulation of striated muscle cell apoptotic process (GO:0010664)6.50935065
22adult heart development (GO:0007512)6.45638154
23mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.39545744
24membrane raft organization (GO:0031579)6.19890234
25muscle cell fate commitment (GO:0042693)6.17830496
26* actomyosin structure organization (GO:0031032)6.13585330
27muscle hypertrophy (GO:0014896)6.13266056
28negative regulation of potassium ion transmembrane transport (GO:1901380)6.06590263
29muscle atrophy (GO:0014889)5.92948532
30ATP synthesis coupled proton transport (GO:0015986)5.92260535
31energy coupled proton transport, down electrochemical gradient (GO:0015985)5.92260535
32regulation of relaxation of muscle (GO:1901077)5.90625561
33regulation of cardioblast differentiation (GO:0051890)5.88880709
34response to muscle activity (GO:0014850)5.79711152
35tricarboxylic acid cycle (GO:0006099)5.78118945
36regulation of sarcomere organization (GO:0060297)5.77373467
37regulation of the force of heart contraction (GO:0002026)5.72316285
38* actin filament-based movement (GO:0030048)5.70526483
39* striated muscle contraction (GO:0006941)5.55611043
40heart trabecula formation (GO:0060347)5.53068663
41oxidative phosphorylation (GO:0006119)5.31129169
42regulation of actin filament-based movement (GO:1903115)5.27877314
43skeletal muscle contraction (GO:0003009)5.25233003
44positive regulation of myotube differentiation (GO:0010831)5.14037470
45ventricular cardiac muscle cell development (GO:0055015)5.05301759
46skeletal muscle tissue regeneration (GO:0043403)5.01011019
47myoblast fusion (GO:0007520)4.96818863
48membrane assembly (GO:0071709)4.96286017
49regulation of striated muscle cell apoptotic process (GO:0010662)4.95447675
50regulation of integrin-mediated signaling pathway (GO:2001044)4.93559696
51positive regulation of myoblast differentiation (GO:0045663)4.88489671
52negative regulation of cardiac muscle tissue growth (GO:0055022)4.84416761
53negative regulation of heart growth (GO:0061117)4.84416761
54bundle of His cell to Purkinje myocyte communication (GO:0086069)4.83993588
55ventricular cardiac muscle cell action potential (GO:0086005)4.83340613
56cardiac muscle adaptation (GO:0014887)4.83025255
57cardiac muscle hypertrophy in response to stress (GO:0014898)4.83025255
58muscle hypertrophy in response to stress (GO:0003299)4.83025255
59regulation of skeletal muscle contraction (GO:0014819)4.82845910
60regulation of striated muscle contraction (GO:0006942)4.76617524
61response to gravity (GO:0009629)4.73346277
62regulation of cardiac muscle cell apoptotic process (GO:0010665)4.69507874
63regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.66425880
64musculoskeletal movement (GO:0050881)4.65734825
65multicellular organismal movement (GO:0050879)4.65734825
66skeletal muscle tissue development (GO:0007519)4.58997947
67regulation of cardiac muscle cell differentiation (GO:2000725)4.58407589
68negative regulation of monooxygenase activity (GO:0032769)4.54993326
69cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.48256588
70negative regulation of cardiac muscle hypertrophy (GO:0010614)4.44002644
71regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.43981360
72negative regulation of protein localization to cell surface (GO:2000009)4.39993517
73regulation of alkaline phosphatase activity (GO:0010692)4.36954413
74atrial septum morphogenesis (GO:0060413)4.36629881
75regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.33225488
76* heart contraction (GO:0060047)4.33136530
77* heart process (GO:0003015)4.33136530
78respiratory electron transport chain (GO:0022904)4.30696580
79outflow tract septum morphogenesis (GO:0003148)4.30685176
80syncytium formation by plasma membrane fusion (GO:0000768)4.27251065
81regulation of ATPase activity (GO:0043462)4.24274499
82regulation of ATP catabolic process (GO:1903289)4.24274499
83electron transport chain (GO:0022900)4.21580202
84cardiac chamber formation (GO:0003207)4.19064029
85striated muscle adaptation (GO:0014888)4.14539585
86muscle organ development (GO:0007517)4.14313363
87striated muscle cell development (GO:0055002)4.11097770
88activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO4.10521830
89cardiac right ventricle morphogenesis (GO:0003215)4.08145194
90negative regulation of myotube differentiation (GO:0010832)4.06701973
91muscle structure development (GO:0061061)4.04597499
92positive regulation of cardiac muscle tissue development (GO:0055025)4.03733401
93negative regulation of cell size (GO:0045792)3.97465148
94regulation of action potential (GO:0098900)3.97219189
95regulation of cell communication by electrical coupling (GO:0010649)3.97069268
96actin filament depolymerization (GO:0030042)3.96419559
97skeletal muscle adaptation (GO:0043501)3.94702038
98regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.93155642
99response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.90333038
100regulation of muscle hypertrophy (GO:0014743)3.88996252
101positive regulation of cardiac muscle cell proliferation (GO:0060045)3.88013297
102plasma membrane repair (GO:0001778)3.87254055
103regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.86758472
104positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.86175898
105negative regulation of cardiac muscle tissue development (GO:0055026)3.85257162
106cell communication by electrical coupling (GO:0010644)3.83158369
107ATP biosynthetic process (GO:0006754)3.82612223
108regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.79377871
109skeletal muscle fiber development (GO:0048741)3.78370159
110negative regulation of potassium ion transport (GO:0043267)3.76463742
111response to inactivity (GO:0014854)3.74524052
112regulation of heart rate (GO:0002027)3.72059749
113trabecula formation (GO:0060343)3.72013708
114cardiac ventricle formation (GO:0003211)3.69650435
115positive regulation of cardiac muscle tissue growth (GO:0055023)3.67436735
116striated muscle tissue development (GO:0014706)3.65691313
117mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.65549599
118positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc3.65467302
119regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.63993968
120regulation of membrane repolarization (GO:0060306)3.63781959
121regulation of cardiac muscle contraction (GO:0055117)3.63212674
122regulation of muscle contraction (GO:0006937)3.62974224
123syncytium formation (GO:0006949)3.62870889
124cell communication involved in cardiac conduction (GO:0086065)3.60388613
125sarcoplasmic reticulum calcium ion transport (GO:0070296)3.59302301
126muscle fiber development (GO:0048747)3.58961300
127cardiac muscle cell action potential involved in contraction (GO:0086002)3.56089316
128muscle cell development (GO:0055001)3.54683259
129myotube cell development (GO:0014904)3.54604706
130positive regulation of ATP catabolic process (GO:1903291)3.53761547
131positive regulation of ATPase activity (GO:0032781)3.53761547
132cytidine deamination (GO:0009972)3.53737382
133cytidine metabolic process (GO:0046087)3.53737382
134cytidine catabolic process (GO:0006216)3.53737382
135cardiac muscle cell action potential (GO:0086001)3.46782365
136positive regulation of striated muscle cell differentiation (GO:0051155)3.46068878
137negative regulation of skeletal muscle tissue development (GO:0048642)3.42195046
138regulation of acyl-CoA biosynthetic process (GO:0050812)3.41569620
139regulation of heart contraction (GO:0008016)3.36115214
140regulation of coenzyme metabolic process (GO:0051196)3.35340358
141regulation of cofactor metabolic process (GO:0051193)3.35340358
142cardiac muscle tissue development (GO:0048738)3.34563857
143regulation of cardiac muscle tissue development (GO:0055024)3.32745603
144regulation of p38MAPK cascade (GO:1900744)3.31227425
145gap junction assembly (GO:0016264)3.30349561
146* muscle contraction (GO:0006936)3.27305035
147negative regulation of organelle assembly (GO:1902116)3.26927890
148positive regulation of cardiac muscle cell differentiation (GO:2000727)3.26921551
149atrioventricular valve morphogenesis (GO:0003181)3.26287573
150neuromuscular junction development (GO:0007528)3.25327101
151regulation of cardiac muscle tissue growth (GO:0055021)3.23422479
152positive regulation of heart growth (GO:0060421)3.22086212
153regulation of cardiac muscle cell proliferation (GO:0060043)3.21954386
154regulation of muscle system process (GO:0090257)3.20806969
155carnitine shuttle (GO:0006853)3.20485707

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EP300_21415370_ChIP-Seq_HL-1_Mouse6.61077326
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.57899460
3ESRRB_18555785_ChIP-Seq_MESCs_Mouse5.24376961
4BP1_19119308_ChIP-ChIP_Hs578T_Human5.01397566
5RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.78892092
6MEF2A_21415370_ChIP-Seq_HL-1_Mouse4.55075231
7CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human4.33960867
8SMAD_19615063_ChIP-ChIP_OVARY_Human3.60245451
9GATA4_21415370_ChIP-Seq_HL-1_Mouse3.56732390
10* TBX20_22080862_ChIP-Seq_HEART_Mouse3.51731443
11* TBX20_22328084_ChIP-Seq_HEART_Mouse3.51731443
12ESR1_20079471_ChIP-ChIP_T-47D_Human3.43093838
13VDR_22108803_ChIP-Seq_LS180_Human3.12272602
14TRIM28_21343339_ChIP-Seq_HEK293_Human3.11808365
15* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.98234286
16EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.72500038
17HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.66463920
18KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.63121568
19PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.60243364
20ISL1_27105846_Chip-Seq_CPCs_Mouse2.55324796
21TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.54146825
22NKX2-5_21415370_ChIP-Seq_HL-1_Mouse2.47347087
23HIF1A_21447827_ChIP-Seq_MCF-7_Human2.45874466
24CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.30629864
25* SRF_21415370_ChIP-Seq_HL-1_Mouse2.29065174
26GATA1_22025678_ChIP-Seq_K562_Human2.22175256
27GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.09547731
28SALL1_21062744_ChIP-ChIP_HESCs_Human2.07885643
29WT1_19549856_ChIP-ChIP_CCG9911_Human2.03205656
30TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.99448193
31BRD4_25478319_ChIP-Seq_HGPS_Human1.99203393
32CREB1_15753290_ChIP-ChIP_HEK293T_Human1.95574975
33PCGF2_27294783_Chip-Seq_NPCs_Mouse1.94545898
34HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.92859435
35TP53_18474530_ChIP-ChIP_U2OS_Human1.87223557
36PIAS1_25552417_ChIP-Seq_VCAP_Human1.81202112
37ZFP57_27257070_Chip-Seq_ESCs_Mouse1.80098878
38SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.72258362
39CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.71522816
40CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.69709082
41PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.68929854
42OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.64777889
43SALL4_18804426_ChIP-ChIP_XEN_Mouse1.63918131
44PPAR_26484153_Chip-Seq_NCI-H1993_Human1.56664571
45BCAT_22108803_ChIP-Seq_LS180_Human1.56624956
46RBPJ_22232070_ChIP-Seq_NCS_Mouse1.54325560
47AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.53626915
48DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.52807745
49MYC_18555785_ChIP-Seq_MESCs_Mouse1.48016849
50BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.47536137
51NFE2_27457419_Chip-Seq_LIVER_Mouse1.47192029
52PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.46071005
53NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.43259644
54CRX_20693478_ChIP-Seq_RETINA_Mouse1.41822077
55IGF1R_20145208_ChIP-Seq_DFB_Human1.40558303
56YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.37061831
57EZH2_27294783_Chip-Seq_NPCs_Mouse1.36120206
58RARG_19884340_ChIP-ChIP_MEFs_Mouse1.33188776
59SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.33129868
60NRF2_20460467_ChIP-Seq_MEFs_Mouse1.32959440
61NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.32959440
62NELFA_20434984_ChIP-Seq_ESCs_Mouse1.32660647
63CDX2_19796622_ChIP-Seq_MESCs_Mouse1.31921466
64SUZ12_27294783_Chip-Seq_NPCs_Mouse1.31762962
65EST1_17652178_ChIP-ChIP_JURKAT_Human1.30500831
66GATA2_21666600_ChIP-Seq_HMVEC_Human1.30463989
67NR3C1_21868756_ChIP-Seq_MCF10A_Human1.29362163
68P53_22387025_ChIP-Seq_ESCs_Mouse1.29201844
69SOX2_18555785_Chip-Seq_ESCs_Mouse1.28798519
70* TBX5_21415370_ChIP-Seq_HL-1_Mouse1.28052383
71CTNNB1_20460455_ChIP-Seq_HCT116_Human1.26900082
72SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.25487820
73* SMAD4_21799915_ChIP-Seq_A2780_Human1.24937401
74E2F1_18555785_Chip-Seq_ESCs_Mouse1.23945645
75NFIB_24661679_ChIP-Seq_LUNG_Mouse1.22595960
76* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.22273044
77MYC_19030024_ChIP-ChIP_MESCs_Mouse1.22190153
78THAP11_20581084_ChIP-Seq_MESCs_Mouse1.20458103
79NANOG_18555785_Chip-Seq_ESCs_Mouse1.20232970
80POU3F2_20337985_ChIP-ChIP_501MEL_Human1.19721348
81TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.19308816
82* STAT3_18555785_Chip-Seq_ESCs_Mouse1.19263695
83ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.18442690
84CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.17775197
85JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.16124597
86FLI1_27457419_Chip-Seq_LIVER_Mouse1.15962169
87* NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.15732311
88TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.15660414
89E2F1_18555785_ChIP-Seq_MESCs_Mouse1.14892376
90TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.14671090
91EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.13827311
92GBX2_23144817_ChIP-Seq_PC3_Human1.12823351
93CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.11335759
94PCGF2_27294783_Chip-Seq_ESCs_Mouse1.11011439
95EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.10257397
96EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.09846357
97GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.07049253
98CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.06422820
99MYC_18358816_ChIP-ChIP_MESCs_Mouse1.05745993
100OCT4_18555785_Chip-Seq_ESCs_Mouse1.05313868
101SOX17_20123909_ChIP-Seq_XEN_Mouse1.04369944
102* RUNX1_27457419_Chip-Seq_LIVER_Mouse1.03270655
103PU1_27457419_Chip-Seq_LIVER_Mouse1.03266873
104KDM2B_26808549_Chip-Seq_REH_Human1.03103185
105PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.02580358
106ZNF274_21170338_ChIP-Seq_K562_Hela1.01579326
107SOX9_24532713_ChIP-Seq_HFSC_Mouse1.00122693
108ETS1_20019798_ChIP-Seq_JURKAT_Human0.99708645
109RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.99586861
110PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.99528868
111TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.99359863
112STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.99351837
113* ZFX_18555785_Chip-Seq_ESCs_Mouse0.99221277
114FUS_26573619_Chip-Seq_HEK293_Human0.98850311
115CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.98829174
116SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.97815563
117AUTS2_25519132_ChIP-Seq_293T-REX_Human0.97814367
118KLF5_20875108_ChIP-Seq_MESCs_Mouse0.96384350
119STAT6_21828071_ChIP-Seq_BEAS2B_Human0.96083169
120CDX2_22108803_ChIP-Seq_LS180_Human0.95913642
121IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.95650670
122CBP_20019798_ChIP-Seq_JUKART_Human0.95650670
123RAD21_21589869_ChIP-Seq_MESCs_Mouse0.95377760
124LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95046264
125STAT3_23295773_ChIP-Seq_U87_Human0.94909899
126FOXM1_23109430_ChIP-Seq_U2OS_Human0.94156719
127HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.92858393
128ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.91687795
129PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.91483007
130SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.91058076
131P300_19829295_ChIP-Seq_ESCs_Human0.90867832
132OCT4_21477851_ChIP-Seq_ESCs_Mouse0.90810075
133CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.90032754
134TP53_16413492_ChIP-PET_HCT116_Human0.89709134
135NANOG_21062744_ChIP-ChIP_HESCs_Human0.89632774
136GABP_17652178_ChIP-ChIP_JURKAT_Human0.89263885
137TP63_19390658_ChIP-ChIP_HaCaT_Human0.88888082
138SMAD3_21741376_ChIP-Seq_HESCs_Human0.87430289
139* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.86392072
140NANOG_18555785_ChIP-Seq_MESCs_Mouse0.86363165
141P300_18555785_Chip-Seq_ESCs_Mouse0.85970764
142SOX9_26525672_Chip-Seq_HEART_Mouse0.85860944
143DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.84108224
144MYC_19829295_ChIP-Seq_ESCs_Human0.83140827
145TOP2B_26459242_ChIP-Seq_MCF-7_Human0.83052105
146SPI1_20517297_ChIP-Seq_HL60_Human0.82807380
147AR_21909140_ChIP-Seq_LNCAP_Human0.82369433
148CMYC_18555785_Chip-Seq_ESCs_Mouse0.81200582
149CTCF_18555785_Chip-Seq_ESCs_Mouse0.80587525
150TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.79568704
151NANOG_16153702_ChIP-ChIP_HESCs_Human0.79184830
152ZFX_18555785_ChIP-Seq_MESCs_Mouse0.77858691
153ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.77208827
154TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.74396448
155ZFP281_18757296_ChIP-ChIP_E14_Mouse0.73180370
156ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.72590131
157NR3C1_23031785_ChIP-Seq_PC12_Mouse0.71844503
158TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.69585256
159RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.69020826
160CJUN_26792858_Chip-Seq_BT549_Human0.67773308
161* CLOCK_20551151_ChIP-Seq_293T_Human0.67663686
162ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.67242251
163LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.64277226
164PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.64214198
165YY1_21170310_ChIP-Seq_MESCs_Mouse0.63675248
166SMC3_22415368_ChIP-Seq_MEFs_Mouse0.63106935
167TP63_17297297_ChIP-ChIP_HaCaT_Human0.61918954
168DCP1A_22483619_ChIP-Seq_HELA_Human0.61869639
169HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.61847637
170GATA1_19941826_ChIP-Seq_K562_Human0.61471130
171SOX3_22085726_ChIP-Seq_NPCs_Mouse0.60518204
172OCT4_20526341_ChIP-Seq_ESCs_Human0.59846350
173CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.59700919
174E2F4_17652178_ChIP-ChIP_JURKAT_Human0.58758066

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0004084_abnormal_cardiac_muscle5.71086347
2MP0002837_dystrophic_cardiac_calcinosis5.00270359
3MP0005330_cardiomyopathy4.40138265
4* MP0000749_muscle_degeneration4.23951157
5MP0004215_abnormal_myocardial_fiber4.17022487
6* MP0004036_abnormal_muscle_relaxation4.08859920
7* MP0002972_abnormal_cardiac_muscle3.71830666
8MP0000751_myopathy3.67877574
9MP0008775_abnormal_heart_ventricle3.56853611
10MP0003646_muscle_fatigue3.18998924
11* MP0004087_abnormal_muscle_fiber3.01683814
12MP0004510_myositis2.97463406
13MP0003137_abnormal_impulse_conducting2.96295559
14* MP0010630_abnormal_cardiac_muscle2.95686126
15MP0006138_congestive_heart_failure2.93376132
16* MP0005620_abnormal_muscle_contractility2.89483829
17MP0003828_pulmonary_edema2.85348461
18MP0004270_analgesia2.68529586
19* MP0001544_abnormal_cardiovascular_syste2.65678449
20* MP0005385_cardiovascular_system_phenoty2.65678449
21MP0003122_maternal_imprinting2.61664979
22MP0002127_abnormal_cardiovascular_syste2.59982014
23MP0004085_abnormal_heartbeat2.54171770
24MP0004145_abnormal_muscle_electrophysio2.41487875
25MP0005451_abnormal_body_composition2.41059080
26MP0002106_abnormal_muscle_physiology2.39161858
27MP0003950_abnormal_plasma_membrane2.38137551
28MP0003567_abnormal_fetal_cardiomyocyte2.34722633
29MP0002269_muscular_atrophy2.32245819
30MP0009780_abnormal_chondrocyte_physiolo2.17053362
31MP0004484_altered_response_of2.07722581
32MP0000750_abnormal_muscle_regeneration2.01558690
33MP0003123_paternal_imprinting1.92941934
34MP0005369_muscle_phenotype1.88413661
35* MP0003221_abnormal_cardiomyocyte_apopto1.86856669
36MP0008438_abnormal_cutaneous_collagen1.80131495
37MP0004233_abnormal_muscle_weight1.79439538
38MP0006036_abnormal_mitochondrial_physio1.70761542
39MP0000747_muscle_weakness1.67356982
40MP0003121_genomic_imprinting1.67132533
41MP0002102_abnormal_ear_morphology1.63746854
42MP0000759_abnormal_skeletal_muscle1.62616721
43MP0008789_abnormal_olfactory_epithelium1.60396700
44MP0005360_urolithiasis1.57250346
45MP0001542_abnormal_bone_strength1.56768982
46MP0003806_abnormal_nucleotide_metabolis1.43403725
47* MP0000266_abnormal_heart_morphology1.39767578
48MP0004883_abnormal_blood_vessel1.36009756
49MP0004272_abnormal_basement_membrane1.32899733
50MP0001299_abnormal_eye_distance/1.31023239
51MP0002332_abnormal_exercise_endurance1.20345183
52MP0003045_fibrosis1.15864891
53MP0009384_cardiac_valve_regurgitation1.15071380
54MP0003279_aneurysm1.14944159
55MP0003566_abnormal_cell_adhesion1.09755494
56MP0002088_abnormal_embryonic_growth/wei1.09375608
57MP0006035_abnormal_mitochondrial_morpho1.08088695
58MP0003984_embryonic_growth_retardation1.07931908
59MP0004130_abnormal_muscle_cell1.07344953
60MP0000372_irregular_coat_pigmentation1.05514213
61MP0003941_abnormal_skin_development0.99640649
62MP0001986_abnormal_taste_sensitivity0.99049041
63MP0002128_abnormal_blood_circulation0.94115157
64MP0003191_abnormal_cellular_cholesterol0.90726969
65MP0001485_abnormal_pinna_reflex0.90154826
66MP0001958_emphysema0.89068490
67MP0000767_abnormal_smooth_muscle0.85704173
68MP0003011_delayed_dark_adaptation0.80217264
69MP0010368_abnormal_lymphatic_system0.79667521
70MP0002234_abnormal_pharynx_morphology0.79135056
71MP0009697_abnormal_copulation0.78264661
72MP0005380_embryogenesis_phenotype0.78201439
73MP0001672_abnormal_embryogenesis/_devel0.78201439
74* MP0002925_abnormal_cardiovascular_devel0.77421991
75MP0000343_altered_response_to0.77415281
76MP0005275_abnormal_skin_tensile0.77154520
77MP0002089_abnormal_postnatal_growth/wei0.75638081
78MP0005266_abnormal_metabolism0.75216859
79MP0001730_embryonic_growth_arrest0.74912322
80MP0005394_taste/olfaction_phenotype0.73090568
81MP0005499_abnormal_olfactory_system0.73090568
82MP0003385_abnormal_body_wall0.71227412
83MP0000537_abnormal_urethra_morphology0.70046055
84MP0001784_abnormal_fluid_regulation0.69280613
85MP0003115_abnormal_respiratory_system0.64973983
86* MP0000230_abnormal_systemic_arterial0.64483856
87MP0005377_hearing/vestibular/ear_phenot0.62742393
88MP0003878_abnormal_ear_physiology0.62742393
89MP0005023_abnormal_wound_healing0.61980828
90MP0001661_extended_life_span0.60215707
91MP0001614_abnormal_blood_vessel0.59249270
92MP0003091_abnormal_cell_migration0.58886207
93MP0005165_increased_susceptibility_to0.58104776
94MP0001697_abnormal_embryo_size0.56457223
95MP0002168_other_aberrant_phenotype0.56199916
96MP0006054_spinal_hemorrhage0.55672402
97MP0002114_abnormal_axial_skeleton0.55251296
98MP0009250_abnormal_appendicular_skeleto0.54680772
99MP0002896_abnormal_bone_mineralization0.54210055
100MP0003705_abnormal_hypodermis_morpholog0.53580145
101MP0002086_abnormal_extraembryonic_tissu0.53228740
102MP0002734_abnormal_mechanical_nocicepti0.51367895
103MP0000762_abnormal_tongue_morphology0.50043866
104MP0009672_abnormal_birth_weight0.49783666
105MP0005171_absent_coat_pigmentation0.49779677
106MP0001879_abnormal_lymphatic_vessel0.49436028
107MP0000013_abnormal_adipose_tissue0.49195795
108MP0000733_abnormal_muscle_development0.48280228
109MP0005164_abnormal_response_to0.47197602
110MP0003948_abnormal_gas_homeostasis0.46667346
111MP0005623_abnormal_meninges_morphology0.46603950
112MP0002184_abnormal_innervation0.45604924
113MP0005595_abnormal_vascular_smooth0.44825392
114MP0010030_abnormal_orbit_morphology0.44120631
115MP0004197_abnormal_fetal_growth/weight/0.43013985
116MP0002233_abnormal_nose_morphology0.42775177
117MP0003959_abnormal_lean_body0.42705175
118MP0005503_abnormal_tendon_morphology0.42463430
119MP0001175_abnormal_lung_morphology0.41011371
120MP0002133_abnormal_respiratory_system0.40979431
121MP0005388_respiratory_system_phenotype0.40979431
122MP0002295_abnormal_pulmonary_circulatio0.39727572
123MP0003942_abnormal_urinary_system0.38025263
124* MP0002080_prenatal_lethality0.36421911
125MP0005670_abnormal_white_adipose0.34960725
126MP0003935_abnormal_craniofacial_develop0.34534018
127MP0005367_renal/urinary_system_phenotyp0.33928721
128MP0000516_abnormal_urinary_system0.33928721
129MP0002108_abnormal_muscle_morphology0.33723588
130MP0003283_abnormal_digestive_organ0.33705969
131MP0000569_abnormal_digit_pigmentation0.33655289
132MP0003119_abnormal_digestive_system0.33491388
133MP0002933_joint_inflammation0.32585062
134MP0001943_abnormal_respiration0.32481437
135MP0008877_abnormal_DNA_methylation0.30414420
136MP0003315_abnormal_perineum_morphology0.29870521
137MP0001727_abnormal_embryo_implantation0.28276094
138MP0002249_abnormal_larynx_morphology0.27910505
139MP0005248_abnormal_Harderian_gland0.27893764
140MP0002282_abnormal_trachea_morphology0.27780975

Predicted human phenotypes

RankGene SetZ-score
1Popliteal pterygium (HP:0009756)9.96140556
2Type 2 muscle fiber atrophy (HP:0003554)9.34272691
3Muscle fiber atrophy (HP:0100295)8.41324554
4Sudden death (HP:0001699)8.07338562
5Abnormality of placental membranes (HP:0011409)7.73506297
6Amniotic constriction ring (HP:0009775)7.73506297
7Abnormality of the neuromuscular junction (HP:0003398)6.99828513
8Fatigable weakness (HP:0003473)6.99828513
9Exercise-induced muscle cramps (HP:0003710)6.68576712
10Calf muscle hypertrophy (HP:0008981)6.55493205
11Ventricular tachycardia (HP:0004756)6.51992925
12Subaortic stenosis (HP:0001682)6.22889820
13Abnormality of the left ventricular outflow tract (HP:0011103)6.22889820
14Atrial fibrillation (HP:0005110)6.21183372
15Weak cry (HP:0001612)6.00315424
16Fetal akinesia sequence (HP:0001989)5.91734847
17Gowers sign (HP:0003391)5.90087088
18Aplasia of the musculature (HP:0100854)5.88457947
19Muscle hypertrophy of the lower extremities (HP:0008968)5.79666904
20Primary atrial arrhythmia (HP:0001692)5.77040403
21Supraventricular tachycardia (HP:0004755)5.61503772
22Supraventricular arrhythmia (HP:0005115)5.48777096
23* Lipoatrophy (HP:0100578)5.42803396
24Abnormality of the calf musculature (HP:0001430)5.22143609
25Easy fatigability (HP:0003388)5.19225863
26Exercise-induced myalgia (HP:0003738)5.13256378
27Malignant hyperthermia (HP:0002047)4.84076052
28Nemaline bodies (HP:0003798)4.70533244
29Pterygium (HP:0001059)4.66145410
30Dilated cardiomyopathy (HP:0001644)4.57984417
31Right ventricular cardiomyopathy (HP:0011663)4.46494151
32Thin ribs (HP:0000883)4.28987373
33Syncope (HP:0001279)4.26582250
34Palpitations (HP:0001962)4.25238324
35EMG: myopathic abnormalities (HP:0003458)4.21387098
36Hyporeflexia of lower limbs (HP:0002600)4.20185474
37Myoglobinuria (HP:0002913)4.15397472
38Prolonged QT interval (HP:0001657)4.15311678
39Centrally nucleated skeletal muscle fibers (HP:0003687)4.08124097
40Akinesia (HP:0002304)3.88147154
41Ragged-red muscle fibers (HP:0003200)3.86622312
42Muscle fiber inclusion bodies (HP:0100299)3.78308761
43Asymmetric septal hypertrophy (HP:0001670)3.71228369
44Congenital malformation of the right heart (HP:0011723)3.66247534
45Double outlet right ventricle (HP:0001719)3.66247534
46* Ventricular arrhythmia (HP:0004308)3.63275100
47Aortic aneurysm (HP:0004942)3.57468728
48Nonprogressive disorder (HP:0003680)3.57074934
49Aplasia/Hypoplasia involving the musculature (HP:0001460)3.54153067
50Acute necrotizing encephalopathy (HP:0006965)3.51785318
51Muscle fiber splitting (HP:0003555)3.51678856
52Rhabdomyolysis (HP:0003201)3.50270188
53Abnormal mitochondria in muscle tissue (HP:0008316)3.42623086
54Increased serum pyruvate (HP:0003542)3.34479554
55Abnormality of glycolysis (HP:0004366)3.34479554
56Cystic hygroma (HP:0000476)3.32455540
57Patent foramen ovale (HP:0001655)3.21403686
58Round ear (HP:0100830)3.16000276
59Ventricular fibrillation (HP:0001663)3.12050837
60Abnormal EKG (HP:0003115)3.10443480
61Type 1 muscle fiber predominance (HP:0003803)3.09316554
62Decreased muscle mass (HP:0003199)3.05940285
63Neoplasm of the adrenal gland (HP:0100631)3.04397704
64Conjunctival hamartoma (HP:0100780)3.02560162
65Depressed nasal tip (HP:0000437)3.00807717
66Distal arthrogryposis (HP:0005684)2.98532499
67Aortic dissection (HP:0002647)2.97361339
68Hepatic necrosis (HP:0002605)2.96935040
69Neck muscle weakness (HP:0000467)2.96673632
70Hypoplastic left heart (HP:0004383)2.93561352
71Exercise intolerance (HP:0003546)2.92507687
72Pheochromocytoma (HP:0002666)2.90269693
73Respiratory insufficiency due to muscle weakness (HP:0002747)2.88593729
74Mitochondrial inheritance (HP:0001427)2.87174468
75Bundle branch block (HP:0011710)2.83132744
76Increased CSF lactate (HP:0002490)2.83049260
77Progressive macrocephaly (HP:0004481)2.81801272
78Acute encephalopathy (HP:0006846)2.81790736
79Poor suck (HP:0002033)2.78019734
80Abnormalities of placenta or umbilical cord (HP:0001194)2.76306966
81Heart block (HP:0012722)2.70417611
82* Palmoplantar keratoderma (HP:0000982)2.67317697
83Atrioventricular block (HP:0001678)2.65210206
84Distal lower limb muscle weakness (HP:0009053)2.64973800
85Diaphragmatic weakness (HP:0009113)2.63970858
86Absent phalangeal crease (HP:0006109)2.62483870
87Neuroendocrine neoplasm (HP:0100634)2.61986285
88Bulbar palsy (HP:0001283)2.61385074
89Hypoplastic heart (HP:0001961)2.60095783
90Generalized muscle weakness (HP:0003324)2.58749573
91Hepatocellular necrosis (HP:0001404)2.58347935
92Rimmed vacuoles (HP:0003805)2.56275584
93Arterial tortuosity (HP:0005116)2.53017878
94Abnormal atrioventricular conduction (HP:0005150)2.50724982
95Ulnar deviation of the wrist (HP:0003049)2.44959884
96* Left ventricular hypertrophy (HP:0001712)2.41154309
97Abnormality of the foot musculature (HP:0001436)2.41077567
98Calcaneovalgus deformity (HP:0001848)2.32044805
99Cerebral edema (HP:0002181)2.30736849
100Vascular tortuosity (HP:0004948)2.29298100
101Myotonia (HP:0002486)2.28471895
102Steppage gait (HP:0003376)2.25599304
103EMG: neuropathic changes (HP:0003445)2.24268350
104Cerebral aneurysm (HP:0004944)2.20691788
105Mildly elevated creatine phosphokinase (HP:0008180)2.20299932
106Preauricular pit (HP:0004467)2.19142680
107Periauricular skin pits (HP:0100277)2.19142680
108Hypoglycemic coma (HP:0001325)2.15249406
109Abnormal finger flexion creases (HP:0006143)2.14726499
110Abnormal ventriculo-arterial connection (HP:0011563)2.12454569
111Transposition of the great arteries (HP:0001669)2.12454569
112Abnormal connection of the cardiac segments (HP:0011545)2.12454569
113Abnormal pupillary function (HP:0007686)2.07210079
114Deformed tarsal bones (HP:0008119)2.05575413
115Lactic acidosis (HP:0003128)2.04272887
116Respiratory failure (HP:0002878)2.02844553
117Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.02779939
118Increased connective tissue (HP:0009025)2.01789770
119Arthrogryposis multiplex congenita (HP:0002804)1.99106098
120Hip contracture (HP:0003273)1.98226938
121Areflexia of lower limbs (HP:0002522)1.97885826
122Muscle stiffness (HP:0003552)1.95632828
123Limb-girdle muscle atrophy (HP:0003797)1.91288750
124Long clavicles (HP:0000890)1.91149549
125Hamartoma of the eye (HP:0010568)1.90587002
126Foot dorsiflexor weakness (HP:0009027)1.90399269
127Lipid accumulation in hepatocytes (HP:0006561)1.90118981
128Increased serum lactate (HP:0002151)1.89995459
129Abnormality of urine glucose concentration (HP:0011016)1.88478461
130Glycosuria (HP:0003076)1.88478461
131Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.86447556
132Diminished movement (HP:0002374)1.83507146
133Hypoplastic ischia (HP:0003175)1.83364268
134Pulmonary artery stenosis (HP:0004415)1.83049420
135Pancreatic islet-cell hyperplasia (HP:0004510)1.82682051
136Increased hepatocellular lipid droplets (HP:0006565)1.79888049
137Ketoacidosis (HP:0001993)1.78975396
138Webbed neck (HP:0000465)1.78488242
139Generalized aminoaciduria (HP:0002909)1.78272551
140Delayed gross motor development (HP:0002194)1.77975997
141Sudden cardiac death (HP:0001645)1.77006833
142Abnormal gallbladder physiology (HP:0012438)1.76996631
143Cholecystitis (HP:0001082)1.76996631
144Abnormality of the endocardium (HP:0004306)1.75764114
145Esophageal neoplasm (HP:0100751)1.75693371
146Neoplasm of head and neck (HP:0012288)1.75693371
147Protrusio acetabuli (HP:0003179)1.75194961
148Increased muscle lipid content (HP:0009058)1.74627905
149Abnormality of the umbilical cord (HP:0010881)1.74539214
150Spondylolisthesis (HP:0003302)1.73832472
151* Congestive heart failure (HP:0001635)1.73060066
152Limited hip movement (HP:0008800)1.69874122
153Abnormality of the ischium (HP:0003174)1.62984555
154Short palpebral fissure (HP:0012745)1.57562875
155Short thorax (HP:0010306)1.52296767
156Metatarsus adductus (HP:0001840)1.49463278
157Reduced subcutaneous adipose tissue (HP:0003758)1.46609922
158Absent septum pellucidum (HP:0001331)1.45278390
159Dyschromatopsia (HP:0007641)1.44912612
160Generalized amyotrophy (HP:0003700)1.42575212

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN9.27481844
2MYLK5.66233429
3STK244.06580655
4CCNB13.95223532
5ZAK3.27186086
6PIK3CA3.02582290
7PKN22.99327581
8STK38L2.88831675
9MAP3K122.66019793
10PIK3CG2.31846930
11DMPK2.25628071
12CDC42BPA2.09206578
13CDK82.08884816
14TTN2.08312299
15LIMK11.96198424
16NEK11.95042627
17BRSK21.79230001
18PDK41.71598363
19PDK31.71598363
20ILK1.69911139
21LMTK21.67706855
22VRK21.66886617
23MUSK1.58994814
24BCKDK1.57508778
25PHKG11.57269748
26PHKG21.57269748
27MOS1.53470888
28TESK11.47635744
29EIF2AK31.43239750
30TRPM71.40979817
31DAPK31.37811971
32TIE11.32837083
33BRSK11.15857557
34ROCK11.09778891
35FLT31.06055116
36PAK41.06044403
37MAPKAPK51.05493035
38PTK2B1.04425226
39TRIB31.01196005
40STK41.01163715
41PRKD30.99695901
42FRK0.98426860
43NUAK10.87760197
44PAK30.87416595
45MARK30.84832205
46TGFBR20.84680179
47PLK40.80700195
48PDK20.78618954
49MAP3K50.78360989
50STK30.76563132
51CAMK2D0.75396559
52DDR20.74304425
53CAMK10.73001932
54FER0.70364552
55EIF2AK10.69020192
56CDK90.68581171
57WNK40.68575121
58PAK20.65264587
59MAP2K30.63584310
60MAP3K30.62089482
61PKN10.61487011
62MAP3K100.60624449
63PRKD10.59483478
64MAPK70.58654157
65MARK10.56653291
66MAP2K10.56473442
67MAPK120.53662297
68CAMK2B0.53522980
69DAPK10.48817321
70PAK60.48417667
71STK160.45467072
72ROCK20.45109952
73PRKACB0.45097187
74KDR0.44505451
75RPS6KC10.44403690
76RPS6KL10.44403690
77PRKAA10.44354669
78MAP3K70.41548247
79BCR0.40446478
80FGFR10.39891276
81EPHB20.38256982
82CAMK2A0.37725695
83PRKAA20.37603671
84PRKD20.37511982
85STK390.36035296
86PRKG10.35483170
87ABL10.35377100
88AKT20.35292788
89RPS6KA60.34544309
90OXSR10.33645108
91AURKB0.33042534
92PTK20.32827714
93PLK30.32730599
94PLK20.30942222
95MAPK40.30687204
96VRK10.30624437
97BMPR1B0.29477849
98WNK10.29445995
99ARAF0.29007107
100EIF2AK20.28386734
101PINK10.27965208
102RAF10.26851565
103PRKACA0.26675904
104UHMK10.26365764
105CAMK40.26243356
106CDK40.26137161
107RIPK10.26023892
108MINK10.22801865
109PRKG20.21299951
110GRK70.21073553
111PAK10.20512840
112CSNK1G20.20187683
113NTRK20.19779368
114PBK0.19538974
115MELK0.19386282
116LATS20.19211485
117FGFR20.18975790
118TTK0.18944325
119CAMK2G0.18694487
120WEE10.18295790
121CSNK2A10.18141375
122MAPKAPK30.17624946
123MARK20.16825555
124NEK90.16693120
125INSR0.16527358
126STK380.16318955
127PRKCE0.16113933
128MAPKAPK20.15695194
129KSR10.15480193
130LRRK20.14590129
131LATS10.13832323
132TAF10.13465122
133INSRR0.13448231
134TNK20.13309571
135CLK10.12998673
136SRPK10.12807922
137PRKCQ0.11991109
138PRKACG0.11738876
139DAPK20.11207804
140CSNK1D0.10443762
141MAP3K110.10017314
142PRKCA0.09278950
143STK110.09153296
144GSK3A0.07536380
145RPS6KA30.06320013

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000206.01366085
2* Cardiac muscle contraction_Homo sapiens_hsa042605.49615165
3Parkinsons disease_Homo sapiens_hsa050124.24978047
4Oxidative phosphorylation_Homo sapiens_hsa001904.03489257
5* Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.84712351
62-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.79101604
7* Dilated cardiomyopathy_Homo sapiens_hsa054143.66819986
8Huntingtons disease_Homo sapiens_hsa050162.92764939
9Alzheimers disease_Homo sapiens_hsa050102.88124094
10Carbon metabolism_Homo sapiens_hsa012002.68605437
11Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.42653512
12Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.31162889
13Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.22890232
14Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.18788250
15Propanoate metabolism_Homo sapiens_hsa006402.11940629
16Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.09419987
17* Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.90786373
18Biosynthesis of amino acids_Homo sapiens_hsa012301.85329640
19Pyruvate metabolism_Homo sapiens_hsa006201.69955428
20Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.53086464
21Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.51514538
22Fatty acid degradation_Homo sapiens_hsa000711.47639993
23Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.44204003
24Circadian rhythm_Homo sapiens_hsa047101.42414248
25Galactose metabolism_Homo sapiens_hsa000521.29590834
26HIF-1 signaling pathway_Homo sapiens_hsa040661.26435730
27Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.22213290
28cGMP-PKG signaling pathway_Homo sapiens_hsa040221.17223367
29Proteasome_Homo sapiens_hsa030501.15532610
30Viral myocarditis_Homo sapiens_hsa054161.14837517
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.13764808
32Selenocompound metabolism_Homo sapiens_hsa004501.12390806
33Renin secretion_Homo sapiens_hsa049241.12196378
34Fatty acid metabolism_Homo sapiens_hsa012121.10396379
35Tight junction_Homo sapiens_hsa045301.09871088
36Fructose and mannose metabolism_Homo sapiens_hsa000511.09171390
37Glucagon signaling pathway_Homo sapiens_hsa049221.03696417
38Central carbon metabolism in cancer_Homo sapiens_hsa052301.02783304
39Gap junction_Homo sapiens_hsa045400.95130047
40Starch and sucrose metabolism_Homo sapiens_hsa005000.88765559
41Fatty acid elongation_Homo sapiens_hsa000620.78096770
42Focal adhesion_Homo sapiens_hsa045100.74738749
43Melanoma_Homo sapiens_hsa052180.72767814
44Vascular smooth muscle contraction_Homo sapiens_hsa042700.70854242
45Phenylalanine metabolism_Homo sapiens_hsa003600.66468417
46p53 signaling pathway_Homo sapiens_hsa041150.63111234
47Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.61707255
48Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.60556902
49Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.60376040
50Salivary secretion_Homo sapiens_hsa049700.59727219
51Pancreatic secretion_Homo sapiens_hsa049720.59378719
52Insulin resistance_Homo sapiens_hsa049310.57198873
53Colorectal cancer_Homo sapiens_hsa052100.57016852
54One carbon pool by folate_Homo sapiens_hsa006700.56823283
55RNA degradation_Homo sapiens_hsa030180.56247586
56Adherens junction_Homo sapiens_hsa045200.53615796
57Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.53473347
58Insulin signaling pathway_Homo sapiens_hsa049100.52589142
59Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.51724245
60Mismatch repair_Homo sapiens_hsa034300.50717480
61Protein digestion and absorption_Homo sapiens_hsa049740.50147536
62Oxytocin signaling pathway_Homo sapiens_hsa049210.49966099
63Tyrosine metabolism_Homo sapiens_hsa003500.49509764
64Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.48666194
65Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.48474443
66Hippo signaling pathway_Homo sapiens_hsa043900.48157135
67Protein export_Homo sapiens_hsa030600.47464993
68Calcium signaling pathway_Homo sapiens_hsa040200.47024527
69Pentose phosphate pathway_Homo sapiens_hsa000300.46166563
70Cysteine and methionine metabolism_Homo sapiens_hsa002700.44183598
71Metabolic pathways_Homo sapiens_hsa011000.41540928
72Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.41502317
73Folate biosynthesis_Homo sapiens_hsa007900.41346300
74Butanoate metabolism_Homo sapiens_hsa006500.41217694
75Legionellosis_Homo sapiens_hsa051340.41035334
76Leukocyte transendothelial migration_Homo sapiens_hsa046700.40945247
77Small cell lung cancer_Homo sapiens_hsa052220.40543919
78Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.40342276
79Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.39917264
80Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.37495102
81Histidine metabolism_Homo sapiens_hsa003400.35638200
82Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.35052415
83Endocytosis_Homo sapiens_hsa041440.33967444
84Oocyte meiosis_Homo sapiens_hsa041140.33876629
85Basal transcription factors_Homo sapiens_hsa030220.31810843
86Caffeine metabolism_Homo sapiens_hsa002320.29261922
87Basal cell carcinoma_Homo sapiens_hsa052170.29190994
88PI3K-Akt signaling pathway_Homo sapiens_hsa041510.29165328
89Homologous recombination_Homo sapiens_hsa034400.29150761
90Cell cycle_Homo sapiens_hsa041100.29024410
91Mineral absorption_Homo sapiens_hsa049780.28382624
92Purine metabolism_Homo sapiens_hsa002300.28302535
93Proteoglycans in cancer_Homo sapiens_hsa052050.28265001
94TGF-beta signaling pathway_Homo sapiens_hsa043500.27786936
95PPAR signaling pathway_Homo sapiens_hsa033200.27654467
96Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.27501522
97Adipocytokine signaling pathway_Homo sapiens_hsa049200.27319928
98Taste transduction_Homo sapiens_hsa047420.27237244
99RNA polymerase_Homo sapiens_hsa030200.25674361
100SNARE interactions in vesicular transport_Homo sapiens_hsa041300.25227160
101Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.23883831
102Pertussis_Homo sapiens_hsa051330.23839275
103AMPK signaling pathway_Homo sapiens_hsa041520.23406258
104Lysine degradation_Homo sapiens_hsa003100.22799984
105AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.22783908
106ECM-receptor interaction_Homo sapiens_hsa045120.21427697
107Steroid biosynthesis_Homo sapiens_hsa001000.20652205
108Regulation of actin cytoskeleton_Homo sapiens_hsa048100.20313591
109Sulfur metabolism_Homo sapiens_hsa009200.18504601
110DNA replication_Homo sapiens_hsa030300.17246296
111Glutathione metabolism_Homo sapiens_hsa004800.17018471
112Peroxisome_Homo sapiens_hsa041460.16753734
113Thyroid hormone signaling pathway_Homo sapiens_hsa049190.14670309
114Ribosome_Homo sapiens_hsa030100.13973002
115Arginine and proline metabolism_Homo sapiens_hsa003300.13615820
116Pyrimidine metabolism_Homo sapiens_hsa002400.13480970
117Circadian entrainment_Homo sapiens_hsa047130.13381496
118Melanogenesis_Homo sapiens_hsa049160.13005222
119cAMP signaling pathway_Homo sapiens_hsa040240.12792254
120Tryptophan metabolism_Homo sapiens_hsa003800.12651947
121RNA transport_Homo sapiens_hsa030130.11958633
122HTLV-I infection_Homo sapiens_hsa051660.11829076
123Nucleotide excision repair_Homo sapiens_hsa034200.11733102
124Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.11388120
125Hedgehog signaling pathway_Homo sapiens_hsa043400.10263131
126Type II diabetes mellitus_Homo sapiens_hsa049300.10095335
127Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.09963943
128beta-Alanine metabolism_Homo sapiens_hsa004100.08770114
129Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.07124160
130Base excision repair_Homo sapiens_hsa034100.05420124
131mRNA surveillance pathway_Homo sapiens_hsa030150.05268047
132Wnt signaling pathway_Homo sapiens_hsa043100.04568540
133Amoebiasis_Homo sapiens_hsa051460.03776547
134Longevity regulating pathway - mammal_Homo sapiens_hsa042110.02466900
135Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.01850975
136Insulin secretion_Homo sapiens_hsa049110.01715480
137FoxO signaling pathway_Homo sapiens_hsa040680.01693381
138Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.00871317

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