ACTG1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Actins are highly conserved proteins that are involved in various types of cell motility, and maintenance of the cytoskeleton. In vertebrates, three main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins co-exist in most cell types as components of the cytoskeleton, and as mediators of internal cell motility. Actin, gamma 1, encoded by this gene, is a cytoplasmic actin found in non-muscle cells. Mutations in this gene are associated with DFNA20/26, a subtype of autosomal dominant non-syndromic sensorineural progressive hearing loss. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of integrated proviral latency (GO:0075713)4.22614887
2pyrimidine nucleobase catabolic process (GO:0006208)4.00818240
3establishment of viral latency (GO:0019043)3.65473474
4planar cell polarity pathway involved in neural tube closure (GO:0090179)3.48169550
5sequestering of actin monomers (GO:0042989)3.47819497
6regulation of protein heterodimerization activity (GO:0043497)3.35399325
7formation of translation preinitiation complex (GO:0001731)3.32333804
8regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.30512403
9spliceosomal tri-snRNP complex assembly (GO:0000244)3.26286467
10Arp2/3 complex-mediated actin nucleation (GO:0034314)3.24479638
11establishment of mitochondrion localization (GO:0051654)3.21742060
12DNA unwinding involved in DNA replication (GO:0006268)3.19188867
13regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.10434262
14regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)3.08924433
15axon extension (GO:0048675)3.08602055
16retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.06917591
17COPI coating of Golgi vesicle (GO:0048205)3.06084309
18Golgi transport vesicle coating (GO:0048200)3.06084309
19mitotic chromosome condensation (GO:0007076)3.01218998
20maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.96931271
21peptidyl-arginine omega-N-methylation (GO:0035247)2.95058986
22layer formation in cerebral cortex (GO:0021819)2.91885413
23heterochromatin organization (GO:0070828)2.90790168
24barbed-end actin filament capping (GO:0051016)2.90609140
25protein retention in ER lumen (GO:0006621)2.89164516
26lens fiber cell development (GO:0070307)2.87847874
27cell migration in hindbrain (GO:0021535)2.87745929
28convergent extension (GO:0060026)2.85274791
29nucleobase catabolic process (GO:0046113)2.82647007
30dosage compensation (GO:0007549)2.82618208
31proline biosynthetic process (GO:0006561)2.82050032
32L-serine metabolic process (GO:0006563)2.80382136
33de novo posttranslational protein folding (GO:0051084)2.77676188
34neuron projection extension (GO:1990138)2.77356559
35ganglion development (GO:0061548)2.76649079
36de novo protein folding (GO:0006458)2.76150567
37glycolytic process (GO:0006096)2.73754855
38mitotic nuclear envelope disassembly (GO:0007077)2.69943151
39protein maturation by protein folding (GO:0022417)2.68008471
40peptidyl-arginine methylation (GO:0018216)2.66780726
41peptidyl-arginine N-methylation (GO:0035246)2.66780726
42G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.66369744
43negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.66237162
44endothelial tube morphogenesis (GO:0061154)2.65932736
45morphogenesis of an endothelium (GO:0003159)2.65932736
46DNA strand elongation involved in DNA replication (GO:0006271)2.64974208
47positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.64150436
48lens morphogenesis in camera-type eye (GO:0002089)2.62380653
49negative regulation of chondrocyte differentiation (GO:0032331)2.61368044
50mitochondrion transport along microtubule (GO:0047497)2.61267524
51establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.61267524
52DNA damage response, detection of DNA damage (GO:0042769)2.60495177
53nuclear envelope disassembly (GO:0051081)2.58857646
54membrane disassembly (GO:0030397)2.58857646
55mitotic sister chromatid segregation (GO:0000070)2.58379014
56Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.56694016
57negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.55860143
58positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.55084117
59regulation of sister chromatid cohesion (GO:0007063)2.54484889
60regulation of mammary gland epithelial cell proliferation (GO:0033599)2.52572306
61dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.52441071
62protein localization to kinetochore (GO:0034501)2.51776132
63positive regulation of mitochondrial fission (GO:0090141)2.51313117
64DNA strand elongation (GO:0022616)2.51295991
65regulation of NFAT protein import into nucleus (GO:0051532)2.51002277
66positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.50713679
67regulation of establishment of planar polarity (GO:0090175)2.49923385
68positive regulation of actin filament depolymerization (GO:0030836)2.49835632
69histone arginine methylation (GO:0034969)2.48789498
70regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.47531595
71RNA localization (GO:0006403)2.46220909
72cholesterol biosynthetic process (GO:0006695)2.46182853
73anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.46104221
74negative regulation of ligase activity (GO:0051352)2.45444736
75negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.45444736
76neuron recognition (GO:0008038)2.45141685
77positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling2.44940540
78regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 2.44940540
79chondrocyte proliferation (GO:0035988)2.44707969
80axonal fasciculation (GO:0007413)2.44486890
81wound healing, spreading of epidermal cells (GO:0035313)2.43024107
82negative regulation of RNA splicing (GO:0033119)2.42640928
83protein localization to microtubule (GO:0035372)2.42196194
84mitotic metaphase plate congression (GO:0007080)2.40392020
85wound healing, spreading of cells (GO:0044319)2.39336980
86sister chromatid segregation (GO:0000819)2.38415315
87actin nucleation (GO:0045010)2.37222951
88mitotic cytokinesis (GO:0000281)2.35887662
89NIK/NF-kappaB signaling (GO:0038061)2.35671843
90mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.35372878
91tRNA aminoacylation for protein translation (GO:0006418)2.34823698
92T cell apoptotic process (GO:0070231)2.34427012
93regulation of translational fidelity (GO:0006450)2.33810120
94ephrin receptor signaling pathway (GO:0048013)2.32360884
95protein insertion into membrane (GO:0051205)2.31314661
96establishment or maintenance of apical/basal cell polarity (GO:0035088)2.30289884
97establishment or maintenance of bipolar cell polarity (GO:0061245)2.30289884
98negative regulation of axon guidance (GO:1902668)2.30175338
99positive regulation of epithelial to mesenchymal transition (GO:0010718)2.29494027
100cochlea morphogenesis (GO:0090103)2.28946220
101cell migration involved in sprouting angiogenesis (GO:0002042)2.28427900
102negative regulation of mRNA processing (GO:0050686)2.27370291
103DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.24755824
104mitotic spindle organization (GO:0007052)2.24040686
105negative regulation of microtubule polymerization (GO:0031115)2.23272825
106ATP-dependent chromatin remodeling (GO:0043044)2.22746604
107DNA replication initiation (GO:0006270)2.22662047
108telomere maintenance via semi-conservative replication (GO:0032201)2.22458073
109amino acid activation (GO:0043038)2.22119906
110tRNA aminoacylation (GO:0043039)2.22119906
111ribosomal small subunit assembly (GO:0000028)2.21673963
112intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.21257140
113signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.21257140
114nuclear pore organization (GO:0006999)2.20879396
115semaphorin-plexin signaling pathway (GO:0071526)2.20705973
116protein complex localization (GO:0031503)2.20473777
117regulation of SMAD protein import into nucleus (GO:0060390)2.20047865
118activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.19586132
119hippo signaling (GO:0035329)2.19360121
120hepatocyte apoptotic process (GO:0097284)2.19327483
121regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.18510150
122maternal placenta development (GO:0001893)2.18153311
123signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.17505680
124signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.17505680
125signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.17505680
126antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.17466650
127regulation of hippo signaling (GO:0035330)2.17391677
128nuclear pore complex assembly (GO:0051292)2.16846337
129protein localization to endosome (GO:0036010)2.16752899
130positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.16485406
131vesicle coating (GO:0006901)2.15714017
132postreplication repair (GO:0006301)2.14611881
133signal transduction involved in cell cycle checkpoint (GO:0072395)2.13975042
134paraxial mesoderm development (GO:0048339)2.13910941
135signal transduction involved in DNA damage checkpoint (GO:0072422)2.13817111
136signal transduction involved in DNA integrity checkpoint (GO:0072401)2.13817111
137mitotic nuclear envelope reassembly (GO:0007084)2.13350648
138nuclear envelope reassembly (GO:0031468)2.13350648
139antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.12346091
140nucleosome disassembly (GO:0006337)2.11644884
141protein-DNA complex disassembly (GO:0032986)2.11644884
142maturation of SSU-rRNA (GO:0030490)2.10928326
143mitotic spindle assembly checkpoint (GO:0007094)2.10718567
144epithelial cell-cell adhesion (GO:0090136)2.10182003
145interferon-gamma secretion (GO:0072643)2.10098293
146membrane budding (GO:0006900)2.09478269
147negative regulation of cell fate specification (GO:0009996)2.09012078
148mitotic recombination (GO:0006312)2.08626682
149nuclear envelope organization (GO:0006998)2.08600207
150actin filament depolymerization (GO:0030042)2.08112010
151positive regulation of cell cycle arrest (GO:0071158)2.07771892
152negative regulation of sister chromatid segregation (GO:0033046)2.07176720
153negative regulation of mitotic sister chromatid separation (GO:2000816)2.07176720
154negative regulation of mitotic sister chromatid segregation (GO:0033048)2.07176720
155negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.07176720
156cullin deneddylation (GO:0010388)2.06702745
157axon extension involved in axon guidance (GO:0048846)2.05668903
158neuron projection extension involved in neuron projection guidance (GO:1902284)2.05668903
159telomere maintenance via recombination (GO:0000722)2.05424124
1603-UTR-mediated mRNA stabilization (GO:0070935)2.04822161
161negative regulation of chromosome segregation (GO:0051985)2.04127328
162spindle assembly checkpoint (GO:0071173)2.04123401
163negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)2.03653971
164establishment of chromosome localization (GO:0051303)2.00429321
165glucocorticoid receptor signaling pathway (GO:0042921)1.99972806
166protein localization to chromosome, centromeric region (GO:0071459)1.99941514
167positive regulation of ligase activity (GO:0051351)1.99779750
168DNA replication-dependent nucleosome assembly (GO:0006335)1.99722564
169DNA replication-dependent nucleosome organization (GO:0034723)1.99722564
170lymphocyte apoptotic process (GO:0070227)1.99431929

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.29359151
2EGR1_19374776_ChIP-ChIP_THP-1_Human4.25097279
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.37185310
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.36121556
5* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.25922922
6TP63_17297297_ChIP-ChIP_HaCaT_Human3.21050478
7MYC_18555785_ChIP-Seq_MESCs_Mouse3.10149745
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.64774288
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.42449754
10MYC_22102868_ChIP-Seq_BL_Human2.36795420
11NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.36309834
12* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.31940403
13E2F4_17652178_ChIP-ChIP_JURKAT_Human2.28493171
14NELFA_20434984_ChIP-Seq_ESCs_Mouse2.20419574
15* XRN2_22483619_ChIP-Seq_HELA_Human2.15248387
16* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.98100198
17MYC_18358816_ChIP-ChIP_MESCs_Mouse1.88860720
18RARG_19884340_ChIP-ChIP_MEFs_Mouse1.81299878
19ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.81205309
20TP63_19390658_ChIP-ChIP_HaCaT_Human1.80223417
21CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.79486996
22FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.79380415
23GABP_17652178_ChIP-ChIP_JURKAT_Human1.78201063
24CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.73716829
25CREB1_15753290_ChIP-ChIP_HEK293T_Human1.69967915
26ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.67366705
27ZNF263_19887448_ChIP-Seq_K562_Human1.64207148
28MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.62071638
29AR_21909140_ChIP-Seq_LNCAP_Human1.61242405
30HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.59346967
31CIITA_25753668_ChIP-Seq_RAJI_Human1.56978946
32* ELK3_25401928_ChIP-Seq_HUVEC_Human1.55770304
33* TTF2_22483619_ChIP-Seq_HELA_Human1.54048472
34ETS1_20019798_ChIP-Seq_JURKAT_Human1.53595621
35* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.53429430
36* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.52724699
37* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.51288077
38RBPJ_22232070_ChIP-Seq_NCS_Mouse1.49812053
39ELF1_17652178_ChIP-ChIP_JURKAT_Human1.49614021
40* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.49362831
41EST1_17652178_ChIP-ChIP_JURKAT_Human1.49218911
42E2F1_21310950_ChIP-Seq_MCF-7_Human1.49040199
43DCP1A_22483619_ChIP-Seq_HELA_Human1.48956812
44ELK1_19687146_ChIP-ChIP_HELA_Human1.48523365
45GABP_19822575_ChIP-Seq_HepG2_Human1.47736821
46ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.43459899
47WT1_19549856_ChIP-ChIP_CCG9911_Human1.42944331
48SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.41773521
49* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.40934161
50MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.40614468
51* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.39348803
52* VDR_21846776_ChIP-Seq_THP-1_Human1.39313913
53JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.38823476
54* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.37992677
55POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.37940749
56KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.36872247
57TFEB_21752829_ChIP-Seq_HELA_Human1.36569411
58ELK1_22589737_ChIP-Seq_MCF10A_Human1.36178219
59NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.35741199
60SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.35728595
61PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.35066427
62ZFP281_18757296_ChIP-ChIP_E14_Mouse1.34592863
63STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.34367640
64* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.34184140
65* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.33506707
66* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.32562480
67PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.32001226
68HIF1A_21447827_ChIP-Seq_MCF-7_Human1.31412585
69MYCN_18555785_ChIP-Seq_MESCs_Mouse1.30645765
70YY1_21170310_ChIP-Seq_MESCs_Mouse1.30518507
71KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.30051309
72VDR_23849224_ChIP-Seq_CD4+_Human1.29463440
73CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.29220998
74* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.26028020
75NANOG_21062744_ChIP-ChIP_HESCs_Human1.25313053
76NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.25206934
77KLF4_18555785_ChIP-Seq_MESCs_Mouse1.25083399
78CLOCK_20551151_ChIP-Seq_293T_Human1.24219619
79HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.24129230
80POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.23870639
81SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.23168724
82SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.23168724
83SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.23072795
84IRF8_21731497_ChIP-ChIP_J774_Mouse1.22579118
85SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.21816495
86SOX2_18555785_ChIP-Seq_MESCs_Mouse1.20688837
87* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.19154582
88TP53_22127205_ChIP-Seq_IMR90_Human1.18740787
89ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.18516620
90SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.18361690
91OCT4_18692474_ChIP-Seq_MEFs_Mouse1.17731196
92TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.17666632
93SOX2_16153702_ChIP-ChIP_HESCs_Human1.16475914
94TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.15587069
95* MAF_26560356_Chip-Seq_TH1_Human1.14749580
96P300_27058665_Chip-Seq_ZR-75-30cells_Human1.14591488
97* ATF3_27146783_Chip-Seq_COLON_Human1.14399762
98CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.13996816
99DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.13647753
100* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.13647280
101OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.13446625
102SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.12918422
103CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.11987785
104SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.11723551
105HOXB4_20404135_ChIP-ChIP_EML_Mouse1.11135982
106NANOG_18555785_ChIP-Seq_MESCs_Mouse1.11060564
107ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.09892304
108SPI1_23547873_ChIP-Seq_NB4_Human1.09861059
109TRIM28_21343339_ChIP-Seq_HEK293_Human1.09004201
110TCF3_18692474_ChIP-Seq_MEFs_Mouse1.08777765
111RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.08284913
112STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.08154206
113ESR1_15608294_ChIP-ChIP_MCF-7_Human1.06925526
114DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.06608379
115EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.06400562
116FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.06237012
117SRY_22984422_ChIP-ChIP_TESTIS_Rat1.04841272
118* EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.04762851
119SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.04736685
120KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.04643488
121PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.04557087
122TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.03464318
123FOXP3_21729870_ChIP-Seq_TREG_Human1.03446057
124SOX2_18692474_ChIP-Seq_MEFs_Mouse1.02948036
125YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.02633936
126MYB_26560356_Chip-Seq_TH2_Human1.02255592
127UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.01335021
128SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.00701387
129* SOX17_20123909_ChIP-Seq_XEN_Mouse1.00329150
130SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.00178656
131KDM5A_27292631_Chip-Seq_BREAST_Human0.98658379
132THAP11_20581084_ChIP-Seq_MESCs_Mouse0.98449974
133* UTX_26944678_Chip-Seq_JUKART_Human0.98092297
134* TCF7_22412390_ChIP-Seq_EML_Mouse0.97529513
135FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.97315953
136SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.96414062
137TET1_21451524_ChIP-Seq_MESCs_Mouse0.95829473

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010352_gastrointestinal_tract_polyps3.06634405
2MP0010030_abnormal_orbit_morphology2.96552493
3MP0003705_abnormal_hypodermis_morpholog2.49466257
4MP0005394_taste/olfaction_phenotype2.43389253
5MP0005499_abnormal_olfactory_system2.43389253
6MP0003693_abnormal_embryo_hatching2.41309298
7MP0000537_abnormal_urethra_morphology2.29724379
8MP0008007_abnormal_cellular_replicative2.21626337
9MP0000778_abnormal_nervous_system2.16752151
10MP0001529_abnormal_vocalization2.15676645
11MP0004957_abnormal_blastocyst_morpholog2.10651292
12MP0003077_abnormal_cell_cycle1.96358359
13MP0003566_abnormal_cell_adhesion1.95574228
14MP0000566_synostosis1.95155750
15MP0005076_abnormal_cell_differentiation1.91491351
16MP0009053_abnormal_anal_canal1.80690527
17MP0003111_abnormal_nucleus_morphology1.76381498
18MP0008932_abnormal_embryonic_tissue1.73698576
19MP0006054_spinal_hemorrhage1.65286397
20MP0003091_abnormal_cell_migration1.61658177
21MP0010094_abnormal_chromosome_stability1.60806072
22MP0008438_abnormal_cutaneous_collagen1.58714483
23MP0002697_abnormal_eye_size1.57907054
24MP0003279_aneurysm1.53734893
25MP0003123_paternal_imprinting1.53571284
26MP0004858_abnormal_nervous_system1.52808144
27MP0002233_abnormal_nose_morphology1.51177983
28MP0001730_embryonic_growth_arrest1.50204656
29MP0005623_abnormal_meninges_morphology1.49725132
30MP0003861_abnormal_nervous_system1.49694485
31MP0001299_abnormal_eye_distance/1.49681731
32MP0000350_abnormal_cell_proliferation1.48285705
33MP0005023_abnormal_wound_healing1.48140706
34MP0003122_maternal_imprinting1.46938949
35MP0000858_altered_metastatic_potential1.46145297
36MP0002092_abnormal_eye_morphology1.45106477
37MP0003942_abnormal_urinary_system1.41681965
38MP0001348_abnormal_lacrimal_gland1.40537870
39MP0004808_abnormal_hematopoietic_stem1.39755705
40MP0000490_abnormal_crypts_of1.39385897
41MP0001958_emphysema1.38470192
42MP0003121_genomic_imprinting1.38439075
43MP0004272_abnormal_basement_membrane1.36411998
44MP0001293_anophthalmia1.35984433
45MP0003385_abnormal_body_wall1.33984678
46MP0006292_abnormal_olfactory_placode1.33419462
47MP0001849_ear_inflammation1.30301569
48MP0005248_abnormal_Harderian_gland1.30295503
49MP0002396_abnormal_hematopoietic_system1.27536303
50MP0010368_abnormal_lymphatic_system1.26813586
51MP0004859_abnormal_synaptic_plasticity1.25055146
52MP0001286_abnormal_eye_development1.24695583
53MP0009672_abnormal_birth_weight1.24518402
54MP0000733_abnormal_muscle_development1.24252948
55MP0009333_abnormal_splenocyte_physiolog1.24228205
56MP0003119_abnormal_digestive_system1.23670080
57MP0001697_abnormal_embryo_size1.22482511
58MP0003221_abnormal_cardiomyocyte_apopto1.22069275
59MP0000762_abnormal_tongue_morphology1.21415252
60MP0008789_abnormal_olfactory_epithelium1.20488957
61MP0004197_abnormal_fetal_growth/weight/1.19695644
62MP0002084_abnormal_developmental_patter1.17548124
63MP0000534_abnormal_ureter_morphology1.17471691
64MP0002085_abnormal_embryonic_tissue1.17154723
65MP0003115_abnormal_respiratory_system1.15991572
66MP0001835_abnormal_antigen_presentation1.15738998
67MP0002184_abnormal_innervation1.14854106
68MP0005275_abnormal_skin_tensile1.14560556
69MP0000569_abnormal_digit_pigmentation1.14421570
70MP0003436_decreased_susceptibility_to1.13486847
71MP0005501_abnormal_skin_physiology1.13117241
72MP0003941_abnormal_skin_development1.12450895
73MP0003938_abnormal_ear_development1.12341194
74MP0003448_altered_tumor_morphology1.11800227
75MP0000685_abnormal_immune_system1.11611285
76MP0000049_abnormal_middle_ear1.11599581
77MP0003763_abnormal_thymus_physiology1.10663507
78MP0005197_abnormal_uvea_morphology1.09820951
79MP0000579_abnormal_nail_morphology1.09392999
80MP0005380_embryogenesis_phenotype1.09353633
81MP0001672_abnormal_embryogenesis/_devel1.09353633
82MP0003890_abnormal_embryonic-extraembry1.08759995
83MP0003315_abnormal_perineum_morphology1.08367185
84MP0002282_abnormal_trachea_morphology1.08125949
85* MP0002081_perinatal_lethality1.06284682
86MP0003984_embryonic_growth_retardation1.05817513
87MP0004233_abnormal_muscle_weight1.04381856
88MP0008058_abnormal_DNA_repair1.04365470
89MP0002086_abnormal_extraembryonic_tissu1.04267422
90MP0002088_abnormal_embryonic_growth/wei1.04217119
91MP0002080_prenatal_lethality1.02676110
92MP0008260_abnormal_autophagy1.01765323
93MP0000462_abnormal_digestive_system0.99116845
94MP0005503_abnormal_tendon_morphology0.98734182
95MP0004811_abnormal_neuron_physiology0.96745117
96MP0003755_abnormal_palate_morphology0.95928983
97MP0000955_abnormal_spinal_cord0.95080274
98MP0002938_white_spotting0.94185663
99MP0002405_respiratory_system_inflammati0.93416088
100MP0002152_abnormal_brain_morphology0.92599833
101MP0001188_hyperpigmentation0.91713956
102MP0002751_abnormal_autonomic_nervous0.91391490
103MP0000516_abnormal_urinary_system0.91309583
104MP0005367_renal/urinary_system_phenotyp0.91309583
105MP0005257_abnormal_intraocular_pressure0.90765624
106MP0001346_abnormal_lacrimal_gland0.89292594
107MP0009250_abnormal_appendicular_skeleto0.89257829
108MP0009278_abnormal_bone_marrow0.89111386
109MP0002932_abnormal_joint_morphology0.89063970
110MP0000432_abnormal_head_morphology0.89014100
111MP0000358_abnormal_cell_content/0.88537766
112MP0009703_decreased_birth_body0.88410879
113MP0010307_abnormal_tumor_latency0.88248640
114MP0002877_abnormal_melanocyte_morpholog0.88005914
115MP0002398_abnormal_bone_marrow0.87124987
116MP0002089_abnormal_postnatal_growth/wei0.86826269
117MP0001915_intracranial_hemorrhage0.86705724
118MP0001340_abnormal_eyelid_morphology0.86622341
119MP0002249_abnormal_larynx_morphology0.86344755
120MP0000703_abnormal_thymus_morphology0.86273594
121MP0005508_abnormal_skeleton_morphology0.86212791
122MP0002925_abnormal_cardiovascular_devel0.85752793
123MP0002822_catalepsy0.85060973
124MP0002452_abnormal_antigen_presenting0.84819400
125MP0002111_abnormal_tail_morphology0.83864032
126MP0010234_abnormal_vibrissa_follicle0.83614205
127MP0005423_abnormal_somatic_nervous0.83462498
128MP0000767_abnormal_smooth_muscle0.82926016
129MP0003937_abnormal_limbs/digits/tail_de0.82840821
130MP0002148_abnormal_hypersensitivity_rea0.81414716
131MP0001819_abnormal_immune_cell0.81066824
132MP0001879_abnormal_lymphatic_vessel0.80770500
133MP0002019_abnormal_tumor_incidence0.80632010
134MP0004133_heterotaxia0.80287503
135MP0002420_abnormal_adaptive_immunity0.80152644
136MP0009785_altered_susceptibility_to0.79257925
137MP0002116_abnormal_craniofacial_bone0.78283274
138MP0003567_abnormal_fetal_cardiomyocyte0.78045211
139MP0000428_abnormal_craniofacial_morphol0.77389442
140MP0002177_abnormal_outer_ear0.76364391
141MP0000313_abnormal_cell_death0.76353038
142MP0003943_abnormal_hepatobiliary_system0.75120768
143MP0003935_abnormal_craniofacial_develop0.75087884

Predicted human phenotypes

RankGene SetZ-score
1Cortical dysplasia (HP:0002539)4.38175674
2Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.26952615
3Short 4th metacarpal (HP:0010044)3.26952615
4Degeneration of anterior horn cells (HP:0002398)3.21513178
5Abnormality of the anterior horn cell (HP:0006802)3.21513178
6High anterior hairline (HP:0009890)3.08408384
7Protrusio acetabuli (HP:0003179)3.01106064
8Selective tooth agenesis (HP:0001592)2.98504685
9Increased density of long bones (HP:0006392)2.93444045
10Wrist flexion contracture (HP:0001239)2.86650596
11Insomnia (HP:0100785)2.65940173
12Shallow orbits (HP:0000586)2.61050965
13Ulnar bowing (HP:0003031)2.57632391
14Abnormality of the calcaneus (HP:0008364)2.56834122
15Atrophy/Degeneration involving motor neurons (HP:0007373)2.56822642
1611 pairs of ribs (HP:0000878)2.47651853
17Spastic diplegia (HP:0001264)2.44307240
18Renal duplication (HP:0000075)2.43693316
19Deviation of the thumb (HP:0009603)2.42715457
20Spinal cord lesions (HP:0100561)2.37034365
21Syringomyelia (HP:0003396)2.37034365
22Generalized hypotonia (HP:0001290)2.36010736
23Dilatation of the ascending aorta (HP:0005111)2.35867830
24Cervical subluxation (HP:0003308)2.34502021
25Hypoplasia of the brainstem (HP:0002365)2.33234573
26Aplasia/Hypoplasia of the brainstem (HP:0007362)2.33234573
27Broad face (HP:0000283)2.23896832
28Overriding aorta (HP:0002623)2.20506516
29Persistence of primary teeth (HP:0006335)2.17205742
30Hyperacusis (HP:0010780)2.16660250
31Aortic aneurysm (HP:0004942)2.16369764
32Microglossia (HP:0000171)2.16007988
33Abnormality of the lower motor neuron (HP:0002366)2.14340358
34Upper limb muscle weakness (HP:0003484)2.12773184
35Abnormality of the 4th metacarpal (HP:0010012)2.12174195
36Pelvic girdle muscle weakness (HP:0003749)2.11176437
37Vertebral compression fractures (HP:0002953)2.10148419
38Premature rupture of membranes (HP:0001788)2.09966975
39* Trigonocephaly (HP:0000243)2.09458336
40Colon cancer (HP:0003003)2.08463358
41Trismus (HP:0000211)2.06930562
42Elfin facies (HP:0004428)2.06178567
43Bowel diverticulosis (HP:0005222)2.05842575
44Shoulder girdle muscle weakness (HP:0003547)2.05182874
45Proximal placement of thumb (HP:0009623)2.05060118
46Termporal pattern (HP:0011008)1.99896755
47Insidious onset (HP:0003587)1.99896755
48Missing ribs (HP:0000921)1.99845204
49Retinal dysplasia (HP:0007973)1.98529253
50Cholecystitis (HP:0001082)1.98019481
51Abnormal gallbladder physiology (HP:0012438)1.98019481
52Glossoptosis (HP:0000162)1.95928533
53Cerebral aneurysm (HP:0004944)1.95454635
54Bladder diverticulum (HP:0000015)1.94247868
55Wormian bones (HP:0002645)1.92427335
56Bicuspid aortic valve (HP:0001647)1.88541290
57Patellar aplasia (HP:0006443)1.88226612
58Spinal cord compression (HP:0002176)1.87393283
59Asymmetry of the thorax (HP:0001555)1.84783177
60Abnormality of the phalanges of the hallux (HP:0010057)1.84505214
61Abnormality of dentin (HP:0010299)1.81326996
62Hypoplastic pelvis (HP:0008839)1.80849227
63Neonatal short-limb short stature (HP:0008921)1.79654587
64Abnormality of the labia minora (HP:0012880)1.79085027
65Aplasia/Hypoplasia of the patella (HP:0006498)1.78028382
66Radial bowing (HP:0002986)1.77758743
67Spinal rigidity (HP:0003306)1.76480905
68Myelomeningocele (HP:0002475)1.76426284
69Abnormality of the antihelix (HP:0009738)1.76129042
70Back pain (HP:0003418)1.75408167
71Increased nuchal translucency (HP:0010880)1.74723100
72Aplasia/Hypoplasia of the clavicles (HP:0006710)1.73730619
73Arnold-Chiari malformation (HP:0002308)1.73302453
74Hypoplasia of the capital femoral epiphysis (HP:0003090)1.72487034
75Hypoventilation (HP:0002791)1.71652206
76Facial hemangioma (HP:0000329)1.71328110
77Long toe (HP:0010511)1.71255482
78Mitral regurgitation (HP:0001653)1.71110535
79Hand muscle atrophy (HP:0009130)1.71045876
80Disproportionate tall stature (HP:0001519)1.71034560
81Atrophic scars (HP:0001075)1.70784800
82Elevated erythrocyte sedimentation rate (HP:0003565)1.70659306
83Limb-girdle muscle weakness (HP:0003325)1.70046518
84Spina bifida occulta (HP:0003298)1.69954735
85Abnormality of the hip-girdle musculature (HP:0001445)1.69797647
86Abnormality of the musculature of the pelvis (HP:0001469)1.69797647
87Abnormality of the aortic arch (HP:0012303)1.69684599
88Mesomelia (HP:0003027)1.67768195
89Megalocornea (HP:0000485)1.67449983
90Deviation of the hallux (HP:0010051)1.67299383
91Ankle contracture (HP:0006466)1.66926071
92Absent epiphyses (HP:0010577)1.66350348
93Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.66350348
94Thrombocytosis (HP:0001894)1.65854104
95Vertebral arch anomaly (HP:0008438)1.65625683
96Abnormality of the umbilical cord (HP:0010881)1.64528656
97Abnormality of the distal phalanx of the thumb (HP:0009617)1.63271361
98Hallux valgus (HP:0001822)1.63080405
99Diminished motivation (HP:0000745)1.63002772
100Short nail (HP:0001799)1.61746389
101Amyotrophic lateral sclerosis (HP:0007354)1.61321367
102Slender long bone (HP:0003100)1.61316827
103Spinal muscular atrophy (HP:0007269)1.61278265
104Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.60768162
105Vertebral hypoplasia (HP:0008417)1.60768162
106Coronal craniosynostosis (HP:0004440)1.60375293
107Fused cervical vertebrae (HP:0002949)1.59773564
108Broad distal phalanx of finger (HP:0009836)1.59430213
109Lower limb amyotrophy (HP:0007210)1.58614298
110Hemivertebrae (HP:0002937)1.58360194
111Abnormality of oral frenula (HP:0000190)1.58336997
112Deep palmar crease (HP:0006191)1.57939963
113* Abnormality of the metopic suture (HP:0005556)1.57635788
114Adducted thumb (HP:0001181)1.57159207
115Distal lower limb amyotrophy (HP:0008944)1.56706319
116Micronodular cirrhosis (HP:0001413)1.56703785
117Short clavicles (HP:0000894)1.56587634
118Vascular tortuosity (HP:0004948)1.55212969
119Entropion (HP:0000621)1.55023362
120Abnormality of abdominal situs (HP:0011620)1.54723660
121Abdominal situs inversus (HP:0003363)1.54723660
122Achilles tendon contracture (HP:0001771)1.54044316
123Flattened epiphyses (HP:0003071)1.53842643
124Limb-girdle muscle atrophy (HP:0003797)1.53805451
125Hydroureter (HP:0000072)1.53487021
126Abnormality of glycolysis (HP:0004366)1.53402133
127Aortic dissection (HP:0002647)1.53294905
128* Long palpebral fissure (HP:0000637)1.53051638
129Pachygyria (HP:0001302)1.52478100
130Agnosia (HP:0010524)1.52077729
131Oligodactyly (HP:0012165)1.51698036
132Gastrointestinal carcinoma (HP:0002672)1.51642884
133Malignant gastrointestinal tract tumors (HP:0006749)1.51642884
134Apathy (HP:0000741)1.51489879
135Peritonitis (HP:0002586)1.51114709
136Failure to thrive in infancy (HP:0001531)1.51001875
137Soft skin (HP:0000977)1.50806110
138Atresia of the external auditory canal (HP:0000413)1.50327805
139Overlapping toe (HP:0001845)1.49574164
140Myositis (HP:0100614)1.49513648
141Natal tooth (HP:0000695)1.49232308
142Neoplasm of the pancreas (HP:0002894)1.48552850
143Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.48495131
144* Optic nerve coloboma (HP:0000588)1.46050914
145Broad thumb (HP:0011304)1.45448366
146Interstitial pulmonary disease (HP:0006530)1.45352827
147Rough bone trabeculation (HP:0100670)1.45122564
148Preauricular skin tag (HP:0000384)1.43964937
149Aseptic necrosis (HP:0010885)1.42756740
150Down-sloping shoulders (HP:0200021)1.42518307
151Thin bony cortex (HP:0002753)1.42185509
152Broad phalanges of the hand (HP:0009768)1.41656762
153Abnormality of the distal phalanges of the toes (HP:0010182)1.41613464
154Short 5th finger (HP:0009237)1.40088530
155Upper limb amyotrophy (HP:0009129)1.39994721
156Distal upper limb amyotrophy (HP:0007149)1.39994721
157Genu recurvatum (HP:0002816)1.39979304
158Camptodactyly of toe (HP:0001836)1.39621422
159* Pointed chin (HP:0000307)1.39452226
160Absent frontal sinuses (HP:0002688)1.39416206

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK14.12103387
2TESK23.09167945
3LIMK13.08913359
4BUB12.90994429
5EPHA22.67645729
6ERBB32.54247881
7TGFBR12.47976763
8TRIM282.31783140
9SIK32.20226764
10TRIB32.12622025
11SMG12.07034779
12PASK2.06308803
13RPS6KA42.02436441
14TTN1.89700066
15ICK1.77832946
16PAK41.76361558
17CDC71.75429732
18TSSK61.75126289
19EPHB21.73166369
20CDK191.66757880
21PIM21.63184075
22MAP2K71.63026256
23EEF2K1.60025927
24NTRK11.59816839
25EIF2AK11.53649028
26MAP3K101.53447088
27RPS6KB21.48120622
28STK101.47814846
29WEE11.43807036
30LATS21.42248039
31ACVR1B1.40022785
32KSR11.37337510
33LRRK21.33871793
34ERBB41.29707216
35BCR1.25416736
36CSNK1G31.23921822
37NEK11.21453954
38PKN21.19681729
39CSNK1A1L1.15476018
40VRK21.13858370
41ILK1.12651209
42SCYL21.12395251
43JAK31.12306074
44PAK61.11167655
45DYRK21.11121034
46KDR1.09788592
47MAP3K81.09050168
48NME21.07805135
49MAP3K111.07360972
50NEK21.05044488
51CDK121.04236685
52PTK21.03961251
53CSNK1G21.03269973
54SIK11.03172870
55TAOK21.02956182
56ARAF1.00659488
57MKNK10.99649751
58MAP3K30.99519153
59PAK10.98841182
60LMTK20.97536130
61FER0.96886792
62PBK0.96307664
63PLK30.96126069
64PTK60.92430537
65PRKD30.92000039
66FGFR10.91479477
67CHUK0.91330893
68MET0.90488714
69PDGFRA0.89909075
70TBK10.89115218
71MAP3K120.88708842
72TTK0.88085195
73CASK0.87963747
74BRSK10.87435924
75AURKA0.85929785
76ROCK20.84325974
77MAP3K140.80707829
78CSNK1G10.80627158
79MAP4K10.79461322
80AURKB0.79311870
81ZAP700.78924367
82PLK40.78385531
83BLK0.77754659
84PLK10.75610149
85EPHB10.75295546
86PAK20.74600478
87ATR0.72070294
88MST1R0.71885133
89BRSK20.71362330
90EPHA30.70858309
91CDK70.69371774
92MAP3K40.69303530
93CCNB10.69292464
94MAP2K30.68570157
95MAPKAPK20.67432438
96MOS0.66853639
97CDK180.63376498
98RPS6KA20.62206094
99NEK90.61934281
100PNCK0.61115968
101ALK0.61098199
102AKT20.60465460
103BCKDK0.59858833
104DYRK30.59588864
105NTRK20.58954751
106MAP3K90.58671177
107DDR20.57400390
108SRPK10.57324640
109MAPKAPK30.56431604
110CDK140.56000873
111BMPR1B0.54227568
112PRKCI0.53258414
113SIK20.52853847
114MAP2K20.52654479
115CDK150.51815211
116DYRK1B0.51786696
117MINK10.51524096
118MAP2K10.50352483
119MTOR0.50234460
120BRAF0.50007180
121CDK11A0.49444654
122BTK0.49240819
123ITK0.49090744
124FGFR40.47269851
125BRD40.46032101
126TAF10.45917049
127MARK10.43798424
128PAK30.43758818
129CHEK10.42253889
130ROCK10.40534894
131CDK60.39699982
132PRKG20.38510088
133CDK80.37745769
134TAOK10.36545165
135CDK90.36338549
136BMX0.34289919
137ERN10.33445179
138CHEK20.32369554

Predicted pathways (KEGG)

RankGene SetZ-score
1* Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.60171108
2Steroid biosynthesis_Homo sapiens_hsa001002.55876244
3Proteasome_Homo sapiens_hsa030502.45397580
4Biosynthesis of amino acids_Homo sapiens_hsa012302.44532083
5DNA replication_Homo sapiens_hsa030302.36868227
6Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.10585051
72-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.98825260
8* Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.95826925
9Spliceosome_Homo sapiens_hsa030401.90837466
10Mismatch repair_Homo sapiens_hsa034301.84601033
11Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.83909151
12Cell cycle_Homo sapiens_hsa041101.82905085
13Base excision repair_Homo sapiens_hsa034101.80975583
14* Shigellosis_Homo sapiens_hsa051311.80452850
15RNA transport_Homo sapiens_hsa030131.78742985
16Pentose phosphate pathway_Homo sapiens_hsa000301.68960781
17Non-homologous end-joining_Homo sapiens_hsa034501.56786968
18Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.50747500
19Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.46592106
20p53 signaling pathway_Homo sapiens_hsa041151.44423802
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.43289876
22Carbon metabolism_Homo sapiens_hsa012001.42710873
23Legionellosis_Homo sapiens_hsa051341.42542811
24Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.40141221
25Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.37397506
26Epstein-Barr virus infection_Homo sapiens_hsa051691.37215910
27* Adherens junction_Homo sapiens_hsa045201.35192915
28Colorectal cancer_Homo sapiens_hsa052101.34481717
29* Hippo signaling pathway_Homo sapiens_hsa043901.33826036
30* Viral myocarditis_Homo sapiens_hsa054161.33633148
31Chronic myeloid leukemia_Homo sapiens_hsa052201.30416751
32Leishmaniasis_Homo sapiens_hsa051401.28773492
33HTLV-I infection_Homo sapiens_hsa051661.28066039
34Nucleotide excision repair_Homo sapiens_hsa034201.27558834
35Antigen processing and presentation_Homo sapiens_hsa046121.27462370
36Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.27345605
37* Vibrio cholerae infection_Homo sapiens_hsa051101.24548590
38Small cell lung cancer_Homo sapiens_hsa052221.24034270
39MicroRNAs in cancer_Homo sapiens_hsa052061.23406032
40* Apoptosis_Homo sapiens_hsa042101.18896059
41Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.18002004
42mRNA surveillance pathway_Homo sapiens_hsa030151.15577229
43Viral carcinogenesis_Homo sapiens_hsa052031.14325685
44Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.13459334
45* Leukocyte transendothelial migration_Homo sapiens_hsa046701.13407353
46* Salmonella infection_Homo sapiens_hsa051321.13151579
47Toxoplasmosis_Homo sapiens_hsa051451.10730963
48AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.10388595
49Sulfur relay system_Homo sapiens_hsa041221.10266666
50* Proteoglycans in cancer_Homo sapiens_hsa052051.09119690
51Bladder cancer_Homo sapiens_hsa052191.08502354
52Gap junction_Homo sapiens_hsa045401.06250104
53Graft-versus-host disease_Homo sapiens_hsa053321.05570880
54RNA polymerase_Homo sapiens_hsa030201.05335234
55Neurotrophin signaling pathway_Homo sapiens_hsa047221.04859757
56Thyroid cancer_Homo sapiens_hsa052161.03462126
57Pancreatic cancer_Homo sapiens_hsa052121.02782456
58Hepatitis B_Homo sapiens_hsa051611.02676849
59TNF signaling pathway_Homo sapiens_hsa046681.02326215
60Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.02282789
61Measles_Homo sapiens_hsa051621.01843164
62Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.01488802
63Ribosome_Homo sapiens_hsa030101.01107513
64Allograft rejection_Homo sapiens_hsa053301.01085174
65Endometrial cancer_Homo sapiens_hsa052131.00583220
66Basal cell carcinoma_Homo sapiens_hsa052171.00015365
67Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.97516461
68Herpes simplex infection_Homo sapiens_hsa051680.96269793
69* Focal adhesion_Homo sapiens_hsa045100.96047425
70Pyrimidine metabolism_Homo sapiens_hsa002400.95423120
71Galactose metabolism_Homo sapiens_hsa000520.93556094
72TGF-beta signaling pathway_Homo sapiens_hsa043500.92990954
73Fructose and mannose metabolism_Homo sapiens_hsa000510.91853532
74NF-kappa B signaling pathway_Homo sapiens_hsa040640.91116654
75Homologous recombination_Homo sapiens_hsa034400.89143346
76Notch signaling pathway_Homo sapiens_hsa043300.88352307
77Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.86353329
78Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.86071069
79T cell receptor signaling pathway_Homo sapiens_hsa046600.85902491
80* Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.85025510
81Alcoholism_Homo sapiens_hsa050340.84159682
82Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.82565108
83* Influenza A_Homo sapiens_hsa051640.82383957
84Melanogenesis_Homo sapiens_hsa049160.82232366
85Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.81556494
86Pathways in cancer_Homo sapiens_hsa052000.80502440
87Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.80281634
88* Regulation of actin cytoskeleton_Homo sapiens_hsa048100.79117885
89Acute myeloid leukemia_Homo sapiens_hsa052210.79067869
90One carbon pool by folate_Homo sapiens_hsa006700.77838683
91Type I diabetes mellitus_Homo sapiens_hsa049400.77734019
92Osteoclast differentiation_Homo sapiens_hsa043800.77597236
93Hedgehog signaling pathway_Homo sapiens_hsa043400.77073040
94Pertussis_Homo sapiens_hsa051330.77069293
95Toll-like receptor signaling pathway_Homo sapiens_hsa046200.76937290
96Vitamin B6 metabolism_Homo sapiens_hsa007500.76321026
97VEGF signaling pathway_Homo sapiens_hsa043700.75916929
98NOD-like receptor signaling pathway_Homo sapiens_hsa046210.75394648
99Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.74984099
100Fatty acid elongation_Homo sapiens_hsa000620.74528972
101N-Glycan biosynthesis_Homo sapiens_hsa005100.74462052
102* Phagosome_Homo sapiens_hsa041450.74271692
103Cysteine and methionine metabolism_Homo sapiens_hsa002700.73582453
104Oocyte meiosis_Homo sapiens_hsa041140.72825128
105RNA degradation_Homo sapiens_hsa030180.72780575
106Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.72436837
107Basal transcription factors_Homo sapiens_hsa030220.70247254
108* Tight junction_Homo sapiens_hsa045300.70116865
109Protein export_Homo sapiens_hsa030600.69767385
110ErbB signaling pathway_Homo sapiens_hsa040120.68980597
111Axon guidance_Homo sapiens_hsa043600.67331487
112HIF-1 signaling pathway_Homo sapiens_hsa040660.67067356
113* Thyroid hormone signaling pathway_Homo sapiens_hsa049190.65725790
114AMPK signaling pathway_Homo sapiens_hsa041520.65369980
115Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.64575860
116ECM-receptor interaction_Homo sapiens_hsa045120.64096113
117Tuberculosis_Homo sapiens_hsa051520.63979474
118Endocytosis_Homo sapiens_hsa041440.63854446
119Amoebiasis_Homo sapiens_hsa051460.62978029
120Jak-STAT signaling pathway_Homo sapiens_hsa046300.62480510
121Selenocompound metabolism_Homo sapiens_hsa004500.62363683
122Prolactin signaling pathway_Homo sapiens_hsa049170.62300889
123B cell receptor signaling pathway_Homo sapiens_hsa046620.61408185
124Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.61371347
125Non-small cell lung cancer_Homo sapiens_hsa052230.60779730
126Prostate cancer_Homo sapiens_hsa052150.60570164
127Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.59224424
128Transcriptional misregulation in cancer_Homo sapiens_hsa052020.58527994
129Melanoma_Homo sapiens_hsa052180.58335327
130Renal cell carcinoma_Homo sapiens_hsa052110.58194289
131Central carbon metabolism in cancer_Homo sapiens_hsa052300.57875274
132PI3K-Akt signaling pathway_Homo sapiens_hsa041510.57680025
133Wnt signaling pathway_Homo sapiens_hsa043100.56795928
134Chemokine signaling pathway_Homo sapiens_hsa040620.55927814
135Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.54603734
136Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.53173168
137Fanconi anemia pathway_Homo sapiens_hsa034600.51434763
138Cocaine addiction_Homo sapiens_hsa050300.51315361
139* Rap1 signaling pathway_Homo sapiens_hsa040150.51227861
140Glioma_Homo sapiens_hsa052140.50982924
141Synaptic vesicle cycle_Homo sapiens_hsa047210.50375698
142Lysine degradation_Homo sapiens_hsa003100.50311387
143Pyruvate metabolism_Homo sapiens_hsa006200.45409818

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