ACTG1P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1base-excision repair, AP site formation (GO:0006285)4.32811223
2platelet dense granule organization (GO:0060155)4.32281811
3sequestering of actin monomers (GO:0042989)4.24229916
4DNA double-strand break processing (GO:0000729)4.23509939
5vitamin transmembrane transport (GO:0035461)4.14530806
6mannosylation (GO:0097502)4.10292544
7cullin deneddylation (GO:0010388)4.06098494
8piRNA metabolic process (GO:0034587)4.01394926
9protein-cofactor linkage (GO:0018065)3.97824453
10positive regulation of mitochondrial fission (GO:0090141)3.91202352
11DNA deamination (GO:0045006)3.88706560
12negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.88000484
13preassembly of GPI anchor in ER membrane (GO:0016254)3.87606801
14histone H2A acetylation (GO:0043968)3.86938705
15resolution of meiotic recombination intermediates (GO:0000712)3.80332168
16water-soluble vitamin biosynthetic process (GO:0042364)3.74171062
17substrate-independent telencephalic tangential migration (GO:0021826)3.65479469
18substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.65479469
19anterograde synaptic vesicle transport (GO:0048490)3.65058000
20protein deneddylation (GO:0000338)3.64191945
21pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.57828969
22response to pheromone (GO:0019236)3.51965651
23respiratory chain complex IV assembly (GO:0008535)3.47125226
24DNA methylation involved in gamete generation (GO:0043046)3.45488171
25C-terminal protein amino acid modification (GO:0018410)3.41414808
26fatty acid elongation (GO:0030497)3.40567139
27pyrimidine nucleobase catabolic process (GO:0006208)3.37154055
28DNA damage response, detection of DNA damage (GO:0042769)3.35352062
29metallo-sulfur cluster assembly (GO:0031163)3.34689728
30iron-sulfur cluster assembly (GO:0016226)3.34689728
31GPI anchor metabolic process (GO:0006505)3.32998643
32regulation of feeding behavior (GO:0060259)3.30085034
33positive regulation of protein homodimerization activity (GO:0090073)3.28404578
34negative regulation of telomere maintenance (GO:0032205)3.26699285
35C-terminal protein lipidation (GO:0006501)3.21292195
36proteasome assembly (GO:0043248)3.19092219
37cell wall macromolecule catabolic process (GO:0016998)3.18130134
38estrogen biosynthetic process (GO:0006703)3.14695050
39GPI anchor biosynthetic process (GO:0006506)3.10212039
40branched-chain amino acid catabolic process (GO:0009083)3.09369193
41synapsis (GO:0007129)3.09111575
42pyrimidine-containing compound transmembrane transport (GO:0072531)3.08778061
43protein neddylation (GO:0045116)3.05910688
44tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.04415564
45RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.04415564
46neural tube formation (GO:0001841)3.03947980
47negative regulation of membrane potential (GO:0045837)3.02172565
48glial cell proliferation (GO:0014009)3.01461099
49regulation of cilium movement (GO:0003352)3.00374348
50pyrimidine nucleotide catabolic process (GO:0006244)2.97761793
51cell wall macromolecule metabolic process (GO:0044036)2.97484523
52adenosine metabolic process (GO:0046085)2.95680803
53male meiosis (GO:0007140)2.94089912
54intraciliary transport (GO:0042073)2.88119568
55cytochrome complex assembly (GO:0017004)2.86915663
56fucose catabolic process (GO:0019317)2.82428268
57L-fucose metabolic process (GO:0042354)2.82428268
58L-fucose catabolic process (GO:0042355)2.82428268
59retinal cone cell development (GO:0046549)2.82334179
60folic acid transport (GO:0015884)2.82163280
61regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.82118347
62regulation of mitotic spindle checkpoint (GO:1903504)2.82118347
63nucleobase catabolic process (GO:0046113)2.80377852
64regulation of mitochondrial fission (GO:0090140)2.77353316
65cornea development in camera-type eye (GO:0061303)2.77044240
66DNA catabolic process, exonucleolytic (GO:0000738)2.73443913
67tRNA processing (GO:0008033)2.72182407
68regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.69058488
69protein localization to cilium (GO:0061512)2.68636133
70negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.68005908
71negative regulation of neurological system process (GO:0031645)2.67926444
72positive regulation of circadian rhythm (GO:0042753)2.65939382
73cellular ketone body metabolic process (GO:0046950)2.64736031
74glycolipid biosynthetic process (GO:0009247)2.60331028
75pseudouridine synthesis (GO:0001522)2.55188757
76peptidyl-histidine modification (GO:0018202)2.54687903
77pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.54105612
78organelle disassembly (GO:1903008)2.52344636
79negative regulation of DNA recombination (GO:0045910)2.50833456
80establishment of mitochondrion localization (GO:0051654)2.50696636
81regulation of cellular amino acid metabolic process (GO:0006521)2.50409354
82regulation of sarcomere organization (GO:0060297)2.50176085
83protein complex biogenesis (GO:0070271)2.48568476
84negative regulation of protein oligomerization (GO:0032460)2.47297117
85somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.47022804
86somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.47022804
87isotype switching (GO:0045190)2.47022804
88anterograde axon cargo transport (GO:0008089)2.45192701
89regulation of glucokinase activity (GO:0033131)2.45028250
90regulation of hexokinase activity (GO:1903299)2.45028250
91regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.44645388
92positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.44568035
93positive regulation of catecholamine secretion (GO:0033605)2.44469684
94negative regulation of transcription regulatory region DNA binding (GO:2000678)2.43730040
95tRNA modification (GO:0006400)2.43349195
96nonmotile primary cilium assembly (GO:0035058)2.42828987
97limb bud formation (GO:0060174)2.42695461
98tRNA metabolic process (GO:0006399)2.42379919
99behavioral response to nicotine (GO:0035095)2.41380354
100regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.39474979

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela4.24725958
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.24052231
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.68674844
4NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.57929380
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.40303075
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.25744248
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.98733762
8VDR_22108803_ChIP-Seq_LS180_Human2.73982239
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.69050793
10TAF15_26573619_Chip-Seq_HEK293_Human2.58732451
11GBX2_23144817_ChIP-Seq_PC3_Human2.50050166
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.38725907
13POU3F2_20337985_ChIP-ChIP_501MEL_Human2.35763335
14ELK1_19687146_ChIP-ChIP_HELA_Human2.33136955
15IGF1R_20145208_ChIP-Seq_DFB_Human2.32787525
16SALL1_21062744_ChIP-ChIP_HESCs_Human2.20724502
17VDR_23849224_ChIP-Seq_CD4+_Human2.20547211
18ELF1_17652178_ChIP-ChIP_JURKAT_Human2.14104683
19ZFP57_27257070_Chip-Seq_ESCs_Mouse2.13534891
20TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.08616576
21EWS_26573619_Chip-Seq_HEK293_Human1.98681075
22ETS1_20019798_ChIP-Seq_JURKAT_Human1.93982035
23CREB1_15753290_ChIP-ChIP_HEK293T_Human1.91809403
24FLI1_27457419_Chip-Seq_LIVER_Mouse1.88939048
25IRF1_19129219_ChIP-ChIP_H3396_Human1.86384914
26NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.84211238
27PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.81992008
28P300_19829295_ChIP-Seq_ESCs_Human1.80965605
29CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.77135237
30SRF_21415370_ChIP-Seq_HL-1_Mouse1.73895887
31CTBP2_25329375_ChIP-Seq_LNCAP_Human1.73835550
32TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.70665337
33MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.67044420
34FUS_26573619_Chip-Seq_HEK293_Human1.62665473
35PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.60641812
36TP53_22573176_ChIP-Seq_HFKS_Human1.57043447
37MYC_18940864_ChIP-ChIP_HL60_Human1.55272485
38CTBP1_25329375_ChIP-Seq_LNCAP_Human1.52217670
39EZH2_22144423_ChIP-Seq_EOC_Human1.52000066
40NOTCH1_21737748_ChIP-Seq_TLL_Human1.51683231
41FOXP3_21729870_ChIP-Seq_TREG_Human1.47931575
42FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.47584351
43PCGF2_27294783_Chip-Seq_ESCs_Mouse1.46315400
44PADI4_21655091_ChIP-ChIP_MCF-7_Human1.40538075
45GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.39468116
46ER_23166858_ChIP-Seq_MCF-7_Human1.38079166
47GABP_19822575_ChIP-Seq_HepG2_Human1.37284822
48GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.35825360
49CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.30347443
50YY1_21170310_ChIP-Seq_MESCs_Mouse1.24042025
51PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.21298349
52PCGF2_27294783_Chip-Seq_NPCs_Mouse1.20424581
53SUZ12_27294783_Chip-Seq_NPCs_Mouse1.19893772
54UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.19353113
55YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.15933503
56POU5F1_16153702_ChIP-ChIP_HESCs_Human1.15466016
57MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.13793877
58NFE2_27457419_Chip-Seq_LIVER_Mouse1.12139809
59RNF2_27304074_Chip-Seq_NSC_Mouse1.12109980
60KLF5_20875108_ChIP-Seq_MESCs_Mouse1.11938592
61THAP11_20581084_ChIP-Seq_MESCs_Mouse1.11503315
62FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.10458418
63EZH2_27294783_Chip-Seq_NPCs_Mouse1.08481226
64IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.08053868
65CBP_20019798_ChIP-Seq_JUKART_Human1.08053868
66SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06770928
67SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.06100470
68ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.05356628
69NANOG_19829295_ChIP-Seq_ESCs_Human1.04969508
70SOX2_19829295_ChIP-Seq_ESCs_Human1.04969508
71SOX2_16153702_ChIP-ChIP_HESCs_Human1.04132512
72EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.03965567
73NR3C1_21868756_ChIP-Seq_MCF10A_Human1.02077670
74SMAD4_21799915_ChIP-Seq_A2780_Human1.01350470
75OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01196902
76NCOR_22424771_ChIP-Seq_293T_Human1.01194003
77STAT3_23295773_ChIP-Seq_U87_Human0.99855785
78HOXB4_20404135_ChIP-ChIP_EML_Mouse0.99283532
79E2F4_17652178_ChIP-ChIP_JURKAT_Human0.99233476
80AUTS2_25519132_ChIP-Seq_293T-REX_Human0.98411839
81AR_25329375_ChIP-Seq_VCAP_Human0.97727236
82TCF4_22108803_ChIP-Seq_LS180_Human0.96940203
83CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.96871361
84FOXA1_27270436_Chip-Seq_PROSTATE_Human0.96354934
85FOXA1_25329375_ChIP-Seq_VCAP_Human0.96354934
86EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.95899283
87MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.95862360
88MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.95689899
89AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.95523183
90LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94979250
91SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.93480663
92HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.93409777
93BCAT_22108803_ChIP-Seq_LS180_Human0.92789591
94HTT_18923047_ChIP-ChIP_STHdh_Human0.91854941
95FOXA1_21572438_ChIP-Seq_LNCaP_Human0.91722054
96RUNX2_22187159_ChIP-Seq_PCA_Human0.90708377
97CRX_20693478_ChIP-Seq_RETINA_Mouse0.90480948
98AR_20517297_ChIP-Seq_VCAP_Human0.88321778
99BMI1_23680149_ChIP-Seq_NPCS_Mouse0.87708846
100TOP2B_26459242_ChIP-Seq_MCF-7_Human0.86940708

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002102_abnormal_ear_morphology3.25054656
2MP0003011_delayed_dark_adaptation3.16419628
3MP0001188_hyperpigmentation3.05320379
4MP0008877_abnormal_DNA_methylation2.91662731
5MP0001984_abnormal_olfaction2.83142528
6MP0003122_maternal_imprinting2.79406805
7MP0002736_abnormal_nociception_after2.49418984
8MP0004147_increased_porphyrin_level2.36863743
9MP0005645_abnormal_hypothalamus_physiol2.31520495
10MP0001529_abnormal_vocalization2.29764609
11MP0003880_abnormal_central_pattern2.26077431
12MP0006292_abnormal_olfactory_placode2.24803873
13MP0008995_early_reproductive_senescence2.20306994
14MP0001968_abnormal_touch/_nociception2.17066908
15MP0008789_abnormal_olfactory_epithelium2.15222701
16MP0006072_abnormal_retinal_apoptosis2.10131610
17MP0003787_abnormal_imprinting2.04781038
18MP0005499_abnormal_olfactory_system2.01817517
19MP0005394_taste/olfaction_phenotype2.01817517
20MP0003121_genomic_imprinting2.00159379
21MP0001501_abnormal_sleep_pattern1.97835411
22MP0008058_abnormal_DNA_repair1.97014618
23MP0004270_analgesia1.92663524
24MP0005253_abnormal_eye_physiology1.90880997
25MP0005551_abnormal_eye_electrophysiolog1.82703706
26MP0003786_premature_aging1.73599280
27MP0006276_abnormal_autonomic_nervous1.70571332
28MP0008875_abnormal_xenobiotic_pharmacok1.65720436
29MP0002876_abnormal_thyroid_physiology1.63043472
30MP0002751_abnormal_autonomic_nervous1.59576407
31MP0009745_abnormal_behavioral_response1.53373011
32MP0001486_abnormal_startle_reflex1.50625629
33MP0002272_abnormal_nervous_system1.49556798
34MP0002234_abnormal_pharynx_morphology1.49271749
35MP0001986_abnormal_taste_sensitivity1.46765433
36MP0002837_dystrophic_cardiac_calcinosis1.43173010
37MP0005084_abnormal_gallbladder_morpholo1.41671376
38MP0002638_abnormal_pupillary_reflex1.39906534
39MP0004885_abnormal_endolymph1.38515996
40MP0005646_abnormal_pituitary_gland1.31042160
41MP0003693_abnormal_embryo_hatching1.30847171
42MP0009046_muscle_twitch1.30557120
43MP0002572_abnormal_emotion/affect_behav1.26371028
44MP0006035_abnormal_mitochondrial_morpho1.25601317
45MP0002160_abnormal_reproductive_system1.24733528
46MP0001293_anophthalmia1.23187571
47MP0002557_abnormal_social/conspecific_i1.19492870
48MP0008872_abnormal_physiological_respon1.18973722
49MP0001502_abnormal_circadian_rhythm1.18512380
50MP0000631_abnormal_neuroendocrine_gland1.13871478
51MP0003635_abnormal_synaptic_transmissio1.12874627
52MP0002734_abnormal_mechanical_nocicepti1.12305561
53MP0000372_irregular_coat_pigmentation1.11442672
54MP0005367_renal/urinary_system_phenotyp1.10986531
55MP0000516_abnormal_urinary_system1.10986531
56MP0002653_abnormal_ependyma_morphology1.09020068
57MP0002735_abnormal_chemical_nociception1.07050436
58MP0003718_maternal_effect1.04885946
59MP0002822_catalepsy1.04705811
60MP0004133_heterotaxia1.03792268
61MP0003195_calcinosis1.02901789
62MP0002063_abnormal_learning/memory/cond1.02789945
63MP0004859_abnormal_synaptic_plasticity1.01829122
64MP0005075_abnormal_melanosome_morpholog1.00675673
65MP0004142_abnormal_muscle_tone1.00611369
66MP0002184_abnormal_innervation0.99927365
67MP0000647_abnormal_sebaceous_gland0.99821468
68MP0009780_abnormal_chondrocyte_physiolo0.99365808
69MP0002254_reproductive_system_inflammat0.98138244
70MP0002752_abnormal_somatic_nervous0.98027472
71MP0003119_abnormal_digestive_system0.97922594
72MP0001970_abnormal_pain_threshold0.97184908
73MP0000778_abnormal_nervous_system0.97168197
74MP0001177_atelectasis0.97151990
75MP0002210_abnormal_sex_determination0.95929112
76MP0000049_abnormal_middle_ear0.95327620
77MP0002733_abnormal_thermal_nociception0.95087559
78MP0003567_abnormal_fetal_cardiomyocyte0.91331172
79MP0003137_abnormal_impulse_conducting0.91171081
80MP0005423_abnormal_somatic_nervous0.89967719
81MP0003698_abnormal_male_reproductive0.89647926
82MP0003221_abnormal_cardiomyocyte_apopto0.88692465
83MP0004215_abnormal_myocardial_fiber0.88228235
84MP0001929_abnormal_gametogenesis0.87596051
85MP0005365_abnormal_bile_salt0.86972340
86MP0001963_abnormal_hearing_physiology0.84340286
87MP0005389_reproductive_system_phenotype0.83059024
88MP0002069_abnormal_eating/drinking_beha0.83022998
89MP0000653_abnormal_sex_gland0.82929496
90MP0001145_abnormal_male_reproductive0.82110389
91MP0000026_abnormal_inner_ear0.82065920
92MP0002064_seizures0.81869962
93MP0004811_abnormal_neuron_physiology0.80900921
94MP0002067_abnormal_sensory_capabilities0.80330687
95MP0005671_abnormal_response_to0.79532704
96MP0004085_abnormal_heartbeat0.79373215
97MP0005386_behavior/neurological_phenoty0.78888661
98MP0004924_abnormal_behavior0.78888661
99MP0002095_abnormal_skin_pigmentation0.78277871
100MP0005391_vision/eye_phenotype0.76993244

Predicted human phenotypes

RankGene SetZ-score
1Retinal dysplasia (HP:0007973)5.04163054
2Type II lissencephaly (HP:0007260)4.84340221
3Lissencephaly (HP:0001339)4.21416595
4Abnormality of the labia minora (HP:0012880)3.43478861
5Polyphagia (HP:0002591)3.29841981
6Pancreatic cysts (HP:0001737)3.04827350
7Medial flaring of the eyebrow (HP:0010747)2.94077309
8True hermaphroditism (HP:0010459)2.84878905
9Pancreatic fibrosis (HP:0100732)2.82541537
10Congenital stationary night blindness (HP:0007642)2.79070759
11Nephrogenic diabetes insipidus (HP:0009806)2.77146084
12Gait imbalance (HP:0002141)2.77069426
13Congenital primary aphakia (HP:0007707)2.68832223
14Renal cortical cysts (HP:0000803)2.68326585
153-Methylglutaconic aciduria (HP:0003535)2.65442316
16Methylmalonic acidemia (HP:0002912)2.64094090
17Abolished electroretinogram (ERG) (HP:0000550)2.62828288
18Inability to walk (HP:0002540)2.61491038
19Abnormality of midbrain morphology (HP:0002418)2.61221481
20Molar tooth sign on MRI (HP:0002419)2.61221481
21Pachygyria (HP:0001302)2.46557166
22Esotropia (HP:0000565)2.45601677
23Lipid accumulation in hepatocytes (HP:0006561)2.45475494
24Acute necrotizing encephalopathy (HP:0006965)2.44745702
25Cerebellar dysplasia (HP:0007033)2.43326926
26Nephronophthisis (HP:0000090)2.42951390
27Absent speech (HP:0001344)2.42047466
28Acute encephalopathy (HP:0006846)2.31883510
29Methylmalonic aciduria (HP:0012120)2.31229463
30Abnormal biliary tract physiology (HP:0012439)2.25463373
31Bile duct proliferation (HP:0001408)2.25463373
32Mitochondrial inheritance (HP:0001427)2.25174540
33Genital tract atresia (HP:0001827)2.22120866
34Colon cancer (HP:0003003)2.20455169
35Vaginal atresia (HP:0000148)2.18427913
36Decreased electroretinogram (ERG) amplitude (HP:0000654)2.18182366
37Abnormality of the metopic suture (HP:0005556)2.16335388
38Abnormality of the renal cortex (HP:0011035)2.16115234
39Ependymoma (HP:0002888)2.15599972
40Increased CSF lactate (HP:0002490)2.14822405
41Failure to thrive in infancy (HP:0001531)2.14689289
42Thyroid-stimulating hormone excess (HP:0002925)2.13435643
43Pendular nystagmus (HP:0012043)2.13049580
44Progressive inability to walk (HP:0002505)2.12465769
45Cerebral edema (HP:0002181)2.11412391
46Abnormal mitochondria in muscle tissue (HP:0008316)2.07702266
47Cortical dysplasia (HP:0002539)2.07305954
48Postaxial foot polydactyly (HP:0001830)2.05844303
49Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.04513543
50Small hand (HP:0200055)2.04046082
51Postaxial hand polydactyly (HP:0001162)2.02508444
52Narrow forehead (HP:0000341)2.00972464
53Abnormality of aspartate family amino acid metabolism (HP:0010899)1.96284050
54Hyperventilation (HP:0002883)1.94480192
55Abnormal protein glycosylation (HP:0012346)1.93088173
56Abnormal glycosylation (HP:0012345)1.93088173
57Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.93088173
58Abnormal protein N-linked glycosylation (HP:0012347)1.93088173
59Aplasia/hypoplasia of the uterus (HP:0008684)1.91436836
60Aplasia/Hypoplasia of the brainstem (HP:0007362)1.90008734
61Hypoplasia of the brainstem (HP:0002365)1.90008734
62Abnormality of the renal medulla (HP:0100957)1.89198212
63Progressive macrocephaly (HP:0004481)1.88860717
64IgG deficiency (HP:0004315)1.86878182
65Aplasia/Hypoplasia of the tongue (HP:0010295)1.86161912
66Cone-rod dystrophy (HP:0000548)1.85726447
67Poor suck (HP:0002033)1.84808175
68Abnormality of glycine metabolism (HP:0010895)1.83917172
69Abnormality of serine family amino acid metabolism (HP:0010894)1.83917172
70Megaloblastic anemia (HP:0001889)1.80515497
71Type I transferrin isoform profile (HP:0003642)1.80319015
72Agitation (HP:0000713)1.79875898
73Abnormality of dicarboxylic acid metabolism (HP:0010995)1.77292180
74Dicarboxylic aciduria (HP:0003215)1.77292180
75Cystic liver disease (HP:0006706)1.76539620
76Prominent metopic ridge (HP:0005487)1.76120187
77Ketosis (HP:0001946)1.75598669
78Atrophy/Degeneration involving motor neurons (HP:0007373)1.75437519
79Dyschromatopsia (HP:0007641)1.74841308
80Oligodactyly (hands) (HP:0001180)1.74070680
81Short tibia (HP:0005736)1.73822496
82Aplasia/Hypoplasia of the tibia (HP:0005772)1.73637408
83Spastic tetraplegia (HP:0002510)1.73532790
84Hepatocellular necrosis (HP:0001404)1.72717065
85Lethargy (HP:0001254)1.72084872
86Optic disc pallor (HP:0000543)1.72027269
87Increased corneal curvature (HP:0100692)1.71991372
88Keratoconus (HP:0000563)1.71991372
89Optic nerve hypoplasia (HP:0000609)1.71984576
90Tented upper lip vermilion (HP:0010804)1.71966011
91Increased hepatocellular lipid droplets (HP:0006565)1.71239925
92Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.70959420
93Supernumerary spleens (HP:0009799)1.70175582
94Attenuation of retinal blood vessels (HP:0007843)1.69772515
95Muscular hypotonia of the trunk (HP:0008936)1.69565321
96Drooling (HP:0002307)1.69296902
97Hepatic necrosis (HP:0002605)1.69166274
98Dandy-Walker malformation (HP:0001305)1.69130695
99Abnormal eating behavior (HP:0100738)1.67927565
100Meckel diverticulum (HP:0002245)1.67924416

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K24.44386012
2TESK23.84414732
3BCKDK3.59517988
4TRIM283.05778363
5MAP2K72.88649259
6TAOK32.83111447
7MAP3K42.71417659
8MARK12.57435606
9BCR2.42768754
10TSSK62.33487744
11SRPK12.27291045
12NUAK12.19954474
13ZAK2.06194437
14BUB11.91565913
15WNK31.91398529
16MAPK131.83234089
17GRK11.65493903
18CSNK1G31.64897712
19CSNK1G21.57956764
20ERBB31.54377989
21CSNK1A1L1.53224225
22CSNK1G11.51186976
23STK38L1.51089246
24PINK11.47060936
25CASK1.39610643
26ADRBK21.38710696
27TLK11.36961742
28PAK61.32699565
29VRK11.26045925
30MKNK11.24487870
31NEK11.21505837
32TIE11.20913578
33MST41.19824170
34PAK31.14963416
35DYRK21.12569841
36AKT31.11869003
37CCNB11.11380967
38PLK31.10499533
39MKNK21.10136041
40VRK21.08887899
41FRK1.08611491
42EPHA31.03939869
43TNIK1.03134902
44LIMK11.01755364
45BMPR1B0.96222411
46PLK20.94455203
47RPS6KA40.92082848
48CDK190.90944747
49PBK0.89676012
50EIF2AK30.87634342
51PHKG10.87630865
52PHKG20.87630865
53INSRR0.86323218
54OXSR10.82830006
55MINK10.82416952
56PLK40.81399183
57TXK0.77621939
58PRKCE0.75667271
59ATR0.71747533
60PRKCG0.71361780
61WNK40.62014131
62ACVR1B0.61487482
63TESK10.59800099
64SIK30.58909401
65MATK0.55656423
66PLK10.54389507
67FER0.53115978
68TNK20.50846913
69DAPK10.50510123
70RPS6KA50.49675996
71KDR0.49461258
72CSNK1A10.48400341
73ADRBK10.46649758
74MAP2K40.44452996
75DYRK30.44020269
76CLK10.42162487
77NME10.41407669
78CAMK2A0.41281957
79EPHA40.41184366
80KSR10.40290263
81NTRK20.38729066
82MAP3K50.37266147
83PRKACA0.36478420
84TEC0.36430533
85CSNK2A10.36311330
86PRKACB0.34333712
87ATM0.33160867
88GRK70.32555933
89STK160.32471990
90DAPK20.30950667
91CSNK1D0.27685666
92FLT30.27153287
93PRKG10.26866413
94PRKCI0.25383641
95CSNK1E0.24248246
96CDK50.23256387
97PASK0.23052041
98CDK140.22404962
99PKN10.22026051
100EIF2AK20.20318409

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030603.40295448
2Proteasome_Homo sapiens_hsa030503.28075224
3Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.15735746
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.58168356
5Propanoate metabolism_Homo sapiens_hsa006402.26971647
6Selenocompound metabolism_Homo sapiens_hsa004502.20239451
7Nicotine addiction_Homo sapiens_hsa050332.17239751
8Oxidative phosphorylation_Homo sapiens_hsa001902.15429024
9Sulfur metabolism_Homo sapiens_hsa009202.10286035
10Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.08969824
11Fatty acid elongation_Homo sapiens_hsa000621.97567488
12Basal transcription factors_Homo sapiens_hsa030221.96097812
13Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.94071808
14RNA polymerase_Homo sapiens_hsa030201.92664456
15Phototransduction_Homo sapiens_hsa047441.87245902
16Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.84267283
17Parkinsons disease_Homo sapiens_hsa050121.81807976
18Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.76018486
19Base excision repair_Homo sapiens_hsa034101.71161397
20Butanoate metabolism_Homo sapiens_hsa006501.68411601
21Peroxisome_Homo sapiens_hsa041461.63296546
22Steroid biosynthesis_Homo sapiens_hsa001001.61057779
23Fanconi anemia pathway_Homo sapiens_hsa034601.51781392
24Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.47521539
25Primary bile acid biosynthesis_Homo sapiens_hsa001201.45643712
26RNA degradation_Homo sapiens_hsa030181.42277701
27Caffeine metabolism_Homo sapiens_hsa002321.41165216
28Vitamin digestion and absorption_Homo sapiens_hsa049771.36578751
29Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.32758675
30Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.30822422
31Non-homologous end-joining_Homo sapiens_hsa034501.29389250
32Collecting duct acid secretion_Homo sapiens_hsa049661.28154210
33Taste transduction_Homo sapiens_hsa047421.27917149
34Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.27067927
35alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.25790751
36Homologous recombination_Homo sapiens_hsa034401.23935272
37Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.22526017
38RNA transport_Homo sapiens_hsa030131.20225015
39Fatty acid metabolism_Homo sapiens_hsa012121.17960006
40Huntingtons disease_Homo sapiens_hsa050161.15892148
41Nitrogen metabolism_Homo sapiens_hsa009101.12352734
42Linoleic acid metabolism_Homo sapiens_hsa005911.09305540
43Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.05046451
44Cysteine and methionine metabolism_Homo sapiens_hsa002701.01356677
45GABAergic synapse_Homo sapiens_hsa047271.00843378
46Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.99383951
47Spliceosome_Homo sapiens_hsa030400.99188003
48Ether lipid metabolism_Homo sapiens_hsa005650.97363701
49Purine metabolism_Homo sapiens_hsa002300.96680366
50Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.95445206
51Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.95384423
52Tryptophan metabolism_Homo sapiens_hsa003800.93640338
53Alzheimers disease_Homo sapiens_hsa050100.91343782
54Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.90012231
55Regulation of autophagy_Homo sapiens_hsa041400.89693614
56Pyrimidine metabolism_Homo sapiens_hsa002400.89287684
57Retinol metabolism_Homo sapiens_hsa008300.86446588
582-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.81546160
59Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.80583819
60mRNA surveillance pathway_Homo sapiens_hsa030150.77397287
61Chemical carcinogenesis_Homo sapiens_hsa052040.76853075
62Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.76120996
63Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.74521344
64Metabolic pathways_Homo sapiens_hsa011000.73148334
65Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.72257047
66beta-Alanine metabolism_Homo sapiens_hsa004100.72083943
67Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.71786398
68Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.69756431
69Circadian rhythm_Homo sapiens_hsa047100.69326949
70Primary immunodeficiency_Homo sapiens_hsa053400.69264440
71Olfactory transduction_Homo sapiens_hsa047400.66081742
72Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.63469568
73Oocyte meiosis_Homo sapiens_hsa041140.62729132
74Fatty acid degradation_Homo sapiens_hsa000710.62657797
75Mismatch repair_Homo sapiens_hsa034300.61951401
76Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.61638373
77Synaptic vesicle cycle_Homo sapiens_hsa047210.59120000
78Morphine addiction_Homo sapiens_hsa050320.57295198
79Pyruvate metabolism_Homo sapiens_hsa006200.56762279
80Steroid hormone biosynthesis_Homo sapiens_hsa001400.56665947
81Intestinal immune network for IgA production_Homo sapiens_hsa046720.54968089
82Long-term depression_Homo sapiens_hsa047300.54551796
83Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.52918655
84Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.52821557
85Dopaminergic synapse_Homo sapiens_hsa047280.51343568
86ABC transporters_Homo sapiens_hsa020100.50485426
87Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.48086914
88Vitamin B6 metabolism_Homo sapiens_hsa007500.47818777
89Maturity onset diabetes of the young_Homo sapiens_hsa049500.46584333
90Fat digestion and absorption_Homo sapiens_hsa049750.45372505
91Carbon metabolism_Homo sapiens_hsa012000.44733487
92Biosynthesis of amino acids_Homo sapiens_hsa012300.43257867
93One carbon pool by folate_Homo sapiens_hsa006700.42937778
94Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.41576190
95Cardiac muscle contraction_Homo sapiens_hsa042600.40895368
96Pentose and glucuronate interconversions_Homo sapiens_hsa000400.40019367
97Glutamatergic synapse_Homo sapiens_hsa047240.38143368
98Circadian entrainment_Homo sapiens_hsa047130.37595479
99Vibrio cholerae infection_Homo sapiens_hsa051100.36795882
100Nucleotide excision repair_Homo sapiens_hsa034200.36626379

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