ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	6.01065867
2	cytidine metabolic process (GO:0046087)	5.60451900
3	cytidine catabolic process (GO:0006216)	5.60451900
4	cytidine deamination (GO:0009972)	5.60451900
5	pyrimidine ribonucleoside catabolic process (GO:0046133)	5.03545061
6	response to gravity (GO:0009629)	4.96839480
7	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	4.87256513
8	DNA demethylation (GO:0080111)	4.25655821
9	positive regulation of mitochondrial fission (GO:0090141)	4.25153154
10	protein polyglutamylation (GO:0018095)	4.03196847
11	negative regulation of mast cell activation (GO:0033004)	3.93372806
12	DNA dealkylation (GO:0035510)	3.77945302
13	DNA double-strand break processing (GO:0000729)	3.55873601
14	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.55774536
15	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.55774536
16	water-soluble vitamin biosynthetic process (GO:0042364)	3.54973241
17	platelet dense granule organization (GO:0060155)	3.47440073
18	regulation of activation of Janus kinase activity (GO:0010533)	3.37970813
19	positive regulation of defense response to virus by host (GO:0002230)	3.33440458
20	C-terminal protein lipidation (GO:0006501)	3.24308197
21	skeletal muscle adaptation (GO:0043501)	3.23375444
22	proteasome assembly (GO:0043248)	3.22911885
23	cullin deneddylation (GO:0010388)	3.22748889
24	regulation of relaxation of muscle (GO:1901077)	3.22461042
25	regulation of memory T cell differentiation (GO:0043380)	3.07134542
26	protein deneddylation (GO:0000338)	3.06955662
27	C-terminal protein amino acid modification (GO:0018410)	3.04334181
28	adenosine metabolic process (GO:0046085)	3.03412516
29	peroxisome fission (GO:0016559)	3.02466972
30	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	3.01942827
31	sequestering of actin monomers (GO:0042989)	3.01935163
32	positive regulation of alpha-beta T cell proliferation (GO:0046641)	3.00538779
33	regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)	3.00502019
34	positive regulation of histone H3-K4 methylation (GO:0051571)	2.99896392
35	histone H2A acetylation (GO:0043968)	2.98599062
36	striated muscle atrophy (GO:0014891)	2.91911572
37	negative regulation of T cell apoptotic process (GO:0070233)	2.89604945
38	mismatch repair (GO:0006298)	2.89466338
39	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.87459212
40	branched-chain amino acid catabolic process (GO:0009083)	2.86697850
41	regulation of mitochondrial fission (GO:0090140)	2.86340057
42	anterograde synaptic vesicle transport (GO:0048490)	2.82773299
43	positive regulation of cell fate commitment (GO:0010455)	2.81981616
44	peptidyl-arginine methylation (GO:0018216)	2.81449240
45	peptidyl-arginine N-methylation (GO:0035246)	2.81449240
46	protein K6-linked ubiquitination (GO:0085020)	2.80983584
47	regulation of skeletal muscle contraction (GO:0014819)	2.78394804
48	positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)	2.76883514
49	cellular ketone body metabolic process (GO:0046950)	2.75117802
50	regulation of cellular amino acid metabolic process (GO:0006521)	2.75066093
51	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	2.68832232
52	purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)	2.67975278
53	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.67365773
54	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.67365773
55	negative regulation of execution phase of apoptosis (GO:1900118)	2.66994075
56	mannosylation (GO:0097502)	2.66528351
57	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.65615490
58	muscle atrophy (GO:0014889)	2.65164138
59	reciprocal DNA recombination (GO:0035825)	2.64966004
60	reciprocal meiotic recombination (GO:0007131)	2.64966004
61	actin-myosin filament sliding (GO:0033275)	2.64768959
62	muscle filament sliding (GO:0030049)	2.64768959
63	preassembly of GPI anchor in ER membrane (GO:0016254)	2.61533053
64	adaptation of signaling pathway (GO:0023058)	2.59968903
65	protein complex biogenesis (GO:0070271)	2.59752740
66	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.58919242
67	cell wall macromolecule catabolic process (GO:0016998)	2.58624824
68	rRNA modification (GO:0000154)	2.56695591
69	L-fucose catabolic process (GO:0042355)	2.55978363
70	fucose catabolic process (GO:0019317)	2.55978363
71	L-fucose metabolic process (GO:0042354)	2.55978363
72	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.53524321
73	isotype switching (GO:0045190)	2.53524321
74	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.53524321
75	termination of RNA polymerase III transcription (GO:0006386)	2.52124844
76	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.52124844
77	negative regulation of lymphocyte apoptotic process (GO:0070229)	2.51875036
78	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.51450767
79	negative regulation of ligase activity (GO:0051352)	2.51450767
80	cell wall macromolecule metabolic process (GO:0044036)	2.51243548
81	negative T cell selection (GO:0043383)	2.50761176
82	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.50394382
83	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.49068446
84	deoxyribonucleoside triphosphate metabolic process (GO:0009200)	2.45988910
85	protein neddylation (GO:0045116)	2.45748615
86	regulation of regulatory T cell differentiation (GO:0045589)	2.44623758
87	regulation of hexokinase activity (GO:1903299)	2.44534253
88	regulation of glucokinase activity (GO:0033131)	2.44534253
89	recombinational repair (GO:0000725)	2.43466601
90	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.41674469
91	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.41674469
92	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.41674469
93	amino-acid betaine metabolic process (GO:0006577)	2.41545520
94	rRNA methylation (GO:0031167)	2.41306769
95	photoreceptor cell maintenance (GO:0045494)	2.41202413
96	mitochondrial respiratory chain complex assembly (GO:0033108)	2.40707713
97	negative regulation of telomere maintenance (GO:0032205)	2.40547159
98	double-strand break repair via homologous recombination (GO:0000724)	2.40453382
99	ketone body metabolic process (GO:1902224)	2.40178008
100	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.38790422

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.88921191
2	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.85503044
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.78969641
4	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.56982090
5	VDR_22108803_ChIP-Seq_LS180_Human	3.18497635
6	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.10009740
7	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.86234009
8	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.72196360
9	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.57487912
10	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.53089443
11	ZNF274_21170338_ChIP-Seq_K562_Hela	2.50028634
12	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.46449183
13	TAF15_26573619_Chip-Seq_HEK293_Human	2.43552113
14	VDR_23849224_ChIP-Seq_CD4+_Human	2.34017075
15	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.25381510
16	IGF1R_20145208_ChIP-Seq_DFB_Human	2.17276185
17	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.16441197
18	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	2.08589819
19	GBX2_23144817_ChIP-Seq_PC3_Human	1.96417353
20	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.95406025
21	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.95042572
22	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.90903459
23	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.88424454
24	ELK1_19687146_ChIP-ChIP_HELA_Human	1.85607221
25	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.84083701
26	FOXP3_21729870_ChIP-Seq_TREG_Human	1.83877602
27	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.78950086
28	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.75273109
29	TP53_22573176_ChIP-Seq_HFKS_Human	1.75166577
30	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.75002909
31	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.66883408
32	FUS_26573619_Chip-Seq_HEK293_Human	1.64981880
33	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.60861025
34	MYC_18940864_ChIP-ChIP_HL60_Human	1.59579372
35	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.58802957
36	P300_19829295_ChIP-Seq_ESCs_Human	1.57251671
37	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.55395990
38	EWS_26573619_Chip-Seq_HEK293_Human	1.55261964
39	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.52801433
40	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.52583735
41	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.51432370
42	ER_23166858_ChIP-Seq_MCF-7_Human	1.50743471
43	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.44231580
44	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.43190980
45	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.41516523
46	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.39068922
47	AR_20517297_ChIP-Seq_VCAP_Human	1.38115529
48	GATA3_26560356_Chip-Seq_TH2_Human	1.37284894
49	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.34349693
50	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.33737481
51	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.32470935
52	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.27077889
53	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.25687146
54	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.25668695
55	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.25244591
56	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.24919662
57	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.24794701
58	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.24431735
59	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.24174188
60	NCOR_22424771_ChIP-Seq_293T_Human	1.22201468
61	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.20862081
62	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.20751782
63	CBP_20019798_ChIP-Seq_JUKART_Human	1.20392916
64	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.20392916
65	IRF1_19129219_ChIP-ChIP_H3396_Human	1.20027443
66	SOX2_19829295_ChIP-Seq_ESCs_Human	1.18090117
67	NANOG_19829295_ChIP-Seq_ESCs_Human	1.18090117
68	AR_21572438_ChIP-Seq_LNCaP_Human	1.16495288
69	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.16268996
70	MYB_26560356_Chip-Seq_TH2_Human	1.15324554
71	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.14487630
72	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.13592678
73	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.13592678
74	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.12627464
75	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.11475701
76	CIITA_25753668_ChIP-Seq_RAJI_Human	1.11404122
77	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.09619740
78	BCAT_22108803_ChIP-Seq_LS180_Human	1.08398733
79	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.07255602
80	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.06557437
81	MYC_19829295_ChIP-Seq_ESCs_Human	1.06152074
82	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.04820441
83	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.04797418
84	SMAD4_21799915_ChIP-Seq_A2780_Human	1.03827133
85	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.00624971
86	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.99675008
87	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	0.99615095
88	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.98433291
89	DCP1A_22483619_ChIP-Seq_HELA_Human	0.96563713
90	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.95676628
91	RUNX1_17652178_ChIP-ChIP_JURKAT_Human	0.94962048
92	HOXB7_26014856_ChIP-Seq_BT474_Human	0.94475529
93	GATA3_27048872_Chip-Seq_THYMUS_Human	0.94086101
94	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.93267454
95	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.92503436
96	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.92494787
97	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	0.92289595
98	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.91412072
99	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.91089584
100	GABP_19822575_ChIP-Seq_HepG2_Human	0.89457595

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002837_dystrophic_cardiac_calcinosis	4.84302972
2	MP0004145_abnormal_muscle_electrophysio	3.46819067
3	MP0005671_abnormal_response_to	3.28848471
4	MP0004147_increased_porphyrin_level	3.03313594
5	MP0000569_abnormal_digit_pigmentation	2.97315603
6	MP0002736_abnormal_nociception_after	2.56900662
7	MP0006072_abnormal_retinal_apoptosis	2.53304975
8	MP0003646_muscle_fatigue	2.50692322
9	MP0001968_abnormal_touch/_nociception	2.42417095
10	MP0000372_irregular_coat_pigmentation	2.37160311
11	MP0004036_abnormal_muscle_relaxation	2.11534855
12	MP0008877_abnormal_DNA_methylation	1.96663387
13	MP0008872_abnormal_physiological_respon	1.91811958
14	MP0003045_fibrosis	1.89877526
15	MP0010094_abnormal_chromosome_stability	1.87510661
16	MP0003195_calcinosis	1.83503796
17	MP0002638_abnormal_pupillary_reflex	1.81040312
18	MP0005551_abnormal_eye_electrophysiolog	1.80235968
19	MP0004885_abnormal_endolymph	1.76881936
20	MP0003787_abnormal_imprinting	1.76772702
21	MP0005646_abnormal_pituitary_gland	1.73870803
22	MP0005084_abnormal_gallbladder_morpholo	1.73634072
23	MP0004084_abnormal_cardiac_muscle	1.73162352
24	MP0008058_abnormal_DNA_repair	1.72373086
25	MP0003763_abnormal_thymus_physiology	1.61678948
26	MP0005253_abnormal_eye_physiology	1.61590104
27	MP0003880_abnormal_central_pattern	1.60445305
28	MP0005645_abnormal_hypothalamus_physiol	1.58073811
29	MP0001529_abnormal_vocalization	1.53600206
30	MP0003786_premature_aging	1.53514314
31	MP0002163_abnormal_gland_morphology	1.46799489
32	MP0001984_abnormal_olfaction	1.40319375
33	MP0005075_abnormal_melanosome_morpholog	1.39738534
34	MP0005167_abnormal_blood-brain_barrier	1.39642133
35	MP0005379_endocrine/exocrine_gland_phen	1.34010515
36	MP0006276_abnormal_autonomic_nervous	1.33684142
37	MP0004142_abnormal_muscle_tone	1.30894719
38	MP0003806_abnormal_nucleotide_metabolis	1.29474556
39	MP0002095_abnormal_skin_pigmentation	1.25037010
40	MP0006036_abnormal_mitochondrial_physio	1.24992590
41	MP0001835_abnormal_antigen_presentation	1.24521177
42	MP0009785_altered_susceptibility_to	1.20976819
43	MP0001764_abnormal_homeostasis	1.20828455
44	MP0006035_abnormal_mitochondrial_morpho	1.20476535
45	MP0001485_abnormal_pinna_reflex	1.20253520
46	MP0004215_abnormal_myocardial_fiber	1.19500633
47	MP0002269_muscular_atrophy	1.18750345
48	MP0000747_muscle_weakness	1.16672612
49	MP0001905_abnormal_dopamine_level	1.16460433
50	MP0008875_abnormal_xenobiotic_pharmacok	1.15838369
51	MP0002909_abnormal_adrenal_gland	1.15178997
52	MP0000749_muscle_degeneration	1.12285462
53	MP0005083_abnormal_biliary_tract	1.09151195
54	MP0001919_abnormal_reproductive_system	1.03755372
55	MP0003718_maternal_effect	1.00885696
56	MP0001800_abnormal_humoral_immune	1.00263514
57	MP0005174_abnormal_tail_pigmentation	0.99588340
58	MP0002723_abnormal_immune_serum	0.99542927
59	MP0002653_abnormal_ependyma_morphology	0.99180765
60	MP0002735_abnormal_chemical_nociception	0.98982345
61	MP0003137_abnormal_impulse_conducting	0.98937032
62	MP0009697_abnormal_copulation	0.98770266
63	MP0001486_abnormal_startle_reflex	0.98390354
64	MP0009745_abnormal_behavioral_response	0.98255428
65	MP0002106_abnormal_muscle_physiology	0.95193630
66	MP0000516_abnormal_urinary_system	0.94297533
67	MP0005367_renal/urinary_system_phenotyp	0.94297533
68	MP0002168_other_aberrant_phenotype	0.91175637
69	MP0002148_abnormal_hypersensitivity_rea	0.90368361
70	MP0000465_gastrointestinal_hemorrhage	0.90256340
71	MP0002166_altered_tumor_susceptibility	0.88845119
72	MP0002102_abnormal_ear_morphology	0.88306260
73	MP0000427_abnormal_hair_cycle	0.84145916
74	MP0005000_abnormal_immune_tolerance	0.84109058
75	MP0002420_abnormal_adaptive_immunity	0.83848797
76	MP0005395_other_phenotype	0.82494344
77	MP0005620_abnormal_muscle_contractility	0.82458956
78	MP0002557_abnormal_social/conspecific_i	0.80432892
79	MP0001119_abnormal_female_reproductive	0.78710368
80	MP0003866_abnormal_defecation	0.78586971
81	MP0001819_abnormal_immune_cell	0.78372303
82	MP0002693_abnormal_pancreas_physiology	0.77856340
83	MP0002876_abnormal_thyroid_physiology	0.77232275
84	MP0000703_abnormal_thymus_morphology	0.75512160
85	MP0002277_abnormal_respiratory_mucosa	0.74382796
86	MP0008775_abnormal_heart_ventricle	0.73464786
87	MP0002398_abnormal_bone_marrow	0.73339053
88	MP0002067_abnormal_sensory_capabilities	0.73319100
89	MP0001501_abnormal_sleep_pattern	0.72931260
90	MP0002138_abnormal_hepatobiliary_system	0.72411125
91	MP0000631_abnormal_neuroendocrine_gland	0.72105246
92	MP0009333_abnormal_splenocyte_physiolog	0.72025695
93	MP0002069_abnormal_eating/drinking_beha	0.71878214
94	MP0000371_diluted_coat_color	0.71726046
95	MP0002210_abnormal_sex_determination	0.71129916
96	MP0003011_delayed_dark_adaptation	0.70895340
97	MP0002006_tumorigenesis	0.70890566
98	MP0010386_abnormal_urinary_bladder	0.69704181
99	MP0002938_white_spotting	0.69579875
100	MP0000689_abnormal_spleen_morphology	0.69408167

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hypoproteinemia (HP:0003075)	4.16878952
2	Hepatocellular necrosis (HP:0001404)	3.29986887
3	IgG deficiency (HP:0004315)	3.26547702
4	Severe combined immunodeficiency (HP:0004430)	3.26359662
5	Pancreatic cysts (HP:0001737)	3.24294739
6	Aplastic anemia (HP:0001915)	3.09183982
7	Rectal fistula (HP:0100590)	2.98068537
8	Rectovaginal fistula (HP:0000143)	2.98068537
9	Hepatic necrosis (HP:0002605)	2.93445516
10	Palpebral edema (HP:0100540)	2.88254959
11	Abolished electroretinogram (ERG) (HP:0000550)	2.81446759
12	Abnormality of midbrain morphology (HP:0002418)	2.80343073
13	Molar tooth sign on MRI (HP:0002419)	2.80343073
14	Nephronophthisis (HP:0000090)	2.78753774
15	Thyroiditis (HP:0100646)	2.75609756
16	Mitochondrial inheritance (HP:0001427)	2.75541282
17	Septate vagina (HP:0001153)	2.67123771
18	True hermaphroditism (HP:0010459)	2.65198033
19	Pancreatic fibrosis (HP:0100732)	2.62873853
20	Increased CSF lactate (HP:0002490)	2.61125743
21	B lymphocytopenia (HP:0010976)	2.60724012
22	Chronic hepatic failure (HP:0100626)	2.60091281
23	Medial flaring of the eyebrow (HP:0010747)	2.58686535
24	T lymphocytopenia (HP:0005403)	2.55502034
25	Stomatitis (HP:0010280)	2.52759882
26	Abnormality of B cell number (HP:0010975)	2.49550847
27	Methylmalonic aciduria (HP:0012120)	2.47588903
28	Hyperglycinemia (HP:0002154)	2.46678421
29	Methylmalonic acidemia (HP:0002912)	2.45997284
30	Intestinal fistula (HP:0100819)	2.45050664
31	Congenital stationary night blindness (HP:0007642)	2.44069403
32	Combined immunodeficiency (HP:0005387)	2.43915637
33	Distal arthrogryposis (HP:0005684)	2.43204891
34	Abnormality of T cell number (HP:0011839)	2.40204234
35	Abnormality of the renal cortex (HP:0011035)	2.40108026
36	Abnormal mitochondria in muscle tissue (HP:0008316)	2.39664272
37	Hypothermia (HP:0002045)	2.38757744
38	Vaginal fistula (HP:0004320)	2.38391296
39	Acute necrotizing encephalopathy (HP:0006965)	2.36112484
40	3-Methylglutaconic aciduria (HP:0003535)	2.34700796
41	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.34542248
42	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.34542248
43	Abnormality of the renal medulla (HP:0100957)	2.34254088
44	Abnormal biliary tract physiology (HP:0012439)	2.33395569
45	Bile duct proliferation (HP:0001408)	2.33395569
46	Autoimmune hemolytic anemia (HP:0001890)	2.32331611
47	Abnormal hair whorl (HP:0010721)	2.29170680
48	IgM deficiency (HP:0002850)	2.26756161
49	Generalized aminoaciduria (HP:0002909)	2.24241568
50	Fair hair (HP:0002286)	2.22591943
51	Hyperlipoproteinemia (HP:0010980)	2.20173297
52	Hypoplasia of the pons (HP:0012110)	2.17800616
53	Increased serum lactate (HP:0002151)	2.13979858
54	Increased hepatocellular lipid droplets (HP:0006565)	2.13862806
55	Acute encephalopathy (HP:0006846)	2.10815491
56	Abnormality of T cells (HP:0002843)	2.10034586
57	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.09599316
58	Abnormal protein N-linked glycosylation (HP:0012347)	2.09599316
59	Abnormal protein glycosylation (HP:0012346)	2.09599316
60	Abnormal glycosylation (HP:0012345)	2.09599316
61	Horizontal nystagmus (HP:0000666)	2.07039462
62	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.06297494
63	Lipid accumulation in hepatocytes (HP:0006561)	2.05431725
64	Congenital primary aphakia (HP:0007707)	2.05168621
65	Adactyly (HP:0009776)	2.03842049
66	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.03028595
67	Dicarboxylic aciduria (HP:0003215)	2.03028595
68	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.02319858
69	Abnormality of alanine metabolism (HP:0010916)	2.02319858
70	Hyperalaninemia (HP:0003348)	2.02319858
71	Abnormality of eosinophils (HP:0001879)	2.01265686
72	Absent phalangeal crease (HP:0006109)	2.01129678
73	Type I transferrin isoform profile (HP:0003642)	2.00914521
74	Abnormality of the pons (HP:0007361)	2.00588922
75	Ependymoma (HP:0002888)	2.00441345
76	Renal cortical cysts (HP:0000803)	1.99928004
77	Attenuation of retinal blood vessels (HP:0007843)	1.98688164
78	Increased intramyocellular lipid droplets (HP:0012240)	1.98543909
79	Gait imbalance (HP:0002141)	1.96009218
80	Lactic acidosis (HP:0003128)	1.95487643
81	Progressive macrocephaly (HP:0004481)	1.94801209
82	Intestinal atresia (HP:0011100)	1.94703416
83	Glioma (HP:0009733)	1.94104217
84	Ketosis (HP:0001946)	1.94086077
85	Pancytopenia (HP:0001876)	1.93359504
86	Nephrogenic diabetes insipidus (HP:0009806)	1.91765278
87	Ketoacidosis (HP:0001993)	1.91326482
88	Round ear (HP:0100830)	1.91103650
89	Elevated erythrocyte sedimentation rate (HP:0003565)	1.88220488
90	Abnormal drinking behavior (HP:0030082)	1.87124762
91	Polydipsia (HP:0001959)	1.87124762
92	Vaginal atresia (HP:0000148)	1.86247758
93	Genital tract atresia (HP:0001827)	1.85861036
94	Large for gestational age (HP:0001520)	1.85013255
95	Colon cancer (HP:0003003)	1.83965200
96	Nemaline bodies (HP:0003798)	1.82949903
97	Congenital hepatic fibrosis (HP:0002612)	1.81679519
98	Constricted visual fields (HP:0001133)	1.81600398
99	Abnormality of the prostate (HP:0008775)	1.80775679
100	Renal Fanconi syndrome (HP:0001994)	1.80581424

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	EPHA3	4.03963236
2	TESK2	3.03630617
3	ZAK	3.01563908
4	FRK	2.82212218
5	MAP4K2	2.69466797
6	MAPK13	2.67828513
7	TXK	2.41302096
8	KDR	2.33143433
9	TRIM28	2.33021311
10	NUAK1	2.21005182
11	TIE1	2.18858305
12	TAOK3	2.07554768
13	GRK1	1.99941851
14	BCR	1.98085945
15	TLK1	1.94052564
16	MST4	1.92606598
17	VRK1	1.88879934
18	OBSCN	1.80835468
19	BCKDK	1.70550316
20	VRK2	1.59703450
21	PINK1	1.56041681
22	PIK3CA	1.55377978
23	EIF2AK3	1.50264274
24	ADRBK2	1.46491270
25	SIK3	1.46475257
26	WNK3	1.46130357
27	PKN1	1.45786382
28	CAMKK2	1.36739497
29	PHKG1	1.36462558
30	PHKG2	1.36462558
31	LIMK1	1.36382921
32	CSNK1G3	1.35897086
33	SRPK1	1.35286617
34	INSRR	1.28567885
35	BUB1	1.24598642
36	STK38L	1.23296650
37	MAP2K7	1.20136921
38	CSNK1G1	1.16261892
39	TEC	1.14506449
40	CSNK1A1L	1.12995734
41	CSNK1G2	1.11013978
42	ITK	1.10929081
43	FER	1.09531387
44	TESK1	1.05839571
45	CCNB1	1.01862389
46	PDK2	0.92058458
47	OXSR1	0.82663605
48	DYRK2	0.81660515
49	BLK	0.81418192
50	MAP4K1	0.80941431
51	ERBB3	0.80749988
52	WNK4	0.78927691
53	RPS6KA5	0.74899741
54	IRAK1	0.73190403
55	MAP3K4	0.70534363
56	IKBKB	0.69543019
57	PRKCQ	0.68973380
58	TSSK6	0.68062369
59	BMPR1B	0.67035040
60	PLK3	0.66670376
61	PLK2	0.64386789
62	ATR	0.61507562
63	PLK4	0.60888155
64	STK16	0.60541734
65	TNK2	0.58678924
66	DAPK2	0.58454769
67	MAPKAPK3	0.58449669
68	MAP2K6	0.55888676
69	FES	0.55772541
70	PIK3CG	0.55308195
71	NEK1	0.55254686
72	SYK	0.54337924
73	PRKCE	0.54250121
74	DAPK1	0.54248812
75	LCK	0.51796704
76	CAMK2G	0.48929902
77	PLK1	0.47625017
78	NLK	0.46105550
79	MARK3	0.45394793
80	FLT3	0.43110419
81	STK38	0.41483477
82	RPS6KA4	0.40130828
83	ZAP70	0.39958693
84	BTK	0.38706754
85	MUSK	0.37162334
86	PAK3	0.37098316
87	IKBKE	0.37021503
88	CAMK1	0.36363999
89	CHEK2	0.34845425
90	PBK	0.32285165
91	PIM1	0.32031550
92	AURKA	0.31848528
93	STK39	0.29697094
94	EGFR	0.29595532
95	ROCK1	0.29164267
96	CAMK2D	0.28959866
97	PRKACA	0.28733764
98	ADRBK1	0.28684683
99	GRK6	0.27419414
100	CSNK1A1	0.27252584

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	3.94127927
2	Primary immunodeficiency_Homo sapiens_hsa05340	3.26577617
3	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	3.23508102
4	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.98869611
5	RNA polymerase_Homo sapiens_hsa03020	2.57677672
6	Oxidative phosphorylation_Homo sapiens_hsa00190	2.38839604
7	Protein export_Homo sapiens_hsa03060	2.37619589
8	Regulation of autophagy_Homo sapiens_hsa04140	2.25138612
9	Phototransduction_Homo sapiens_hsa04744	2.16019625
10	Parkinsons disease_Homo sapiens_hsa05012	2.12723252
11	Fanconi anemia pathway_Homo sapiens_hsa03460	2.06105467
12	Homologous recombination_Homo sapiens_hsa03440	1.91787535
13	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.77312408
14	Propanoate metabolism_Homo sapiens_hsa00640	1.63861973
15	Caffeine metabolism_Homo sapiens_hsa00232	1.60305159
16	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.57641245
17	Butanoate metabolism_Homo sapiens_hsa00650	1.50814975
18	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.46101780
19	RNA degradation_Homo sapiens_hsa03018	1.43925059
20	Allograft rejection_Homo sapiens_hsa05330	1.42783503
21	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.41260047
22	Alzheimers disease_Homo sapiens_hsa05010	1.38912567
23	Mismatch repair_Homo sapiens_hsa03430	1.38760753
24	Graft-versus-host disease_Homo sapiens_hsa05332	1.29394377
25	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.25343756
26	Non-homologous end-joining_Homo sapiens_hsa03450	1.25341286
27	Nitrogen metabolism_Homo sapiens_hsa00910	1.24311620
28	Selenocompound metabolism_Homo sapiens_hsa00450	1.21324641
29	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.21282668
30	Basal transcription factors_Homo sapiens_hsa03022	1.20798565
31	Type I diabetes mellitus_Homo sapiens_hsa04940	1.20244751
32	Peroxisome_Homo sapiens_hsa04146	1.20176007
33	Purine metabolism_Homo sapiens_hsa00230	1.20122437
34	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.17066181
35	Steroid biosynthesis_Homo sapiens_hsa00100	1.16472832
36	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.16422792
37	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.16343749
38	Asthma_Homo sapiens_hsa05310	1.15223619
39	Huntingtons disease_Homo sapiens_hsa05016	1.13692683
40	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.13343791
41	Linoleic acid metabolism_Homo sapiens_hsa00591	1.10304420
42	One carbon pool by folate_Homo sapiens_hsa00670	1.09529576
43	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.05241975
44	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.04029787
45	Pyrimidine metabolism_Homo sapiens_hsa00240	1.02248050
46	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.98440526
47	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.97585584
48	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.94286617
49	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.92172631
50	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.91146400
51	Antigen processing and presentation_Homo sapiens_hsa04612	0.89500752
52	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.86690297
53	Olfactory transduction_Homo sapiens_hsa04740	0.86021148
54	Tryptophan metabolism_Homo sapiens_hsa00380	0.84981710
55	Ether lipid metabolism_Homo sapiens_hsa00565	0.83197656
56	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.80209750
57	Base excision repair_Homo sapiens_hsa03410	0.79601495
58	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.79167737
59	Fatty acid elongation_Homo sapiens_hsa00062	0.77606927
60	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.75978141
61	Cardiac muscle contraction_Homo sapiens_hsa04260	0.75946027
62	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.75600229
63	Oocyte meiosis_Homo sapiens_hsa04114	0.72666913
64	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.69295690
65	Alcoholism_Homo sapiens_hsa05034	0.67916815
66	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.67303623
67	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.67209264
68	Spliceosome_Homo sapiens_hsa03040	0.64094018
69	Metabolic pathways_Homo sapiens_hsa01100	0.63838296
70	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.63701514
71	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.63622606
72	Chemical carcinogenesis_Homo sapiens_hsa05204	0.63413075
73	RNA transport_Homo sapiens_hsa03013	0.62045336
74	Sulfur metabolism_Homo sapiens_hsa00920	0.60048802
75	Nicotine addiction_Homo sapiens_hsa05033	0.57689035
76	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.56322158
77	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.55931267
78	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.54287433
79	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.52638263
80	Shigellosis_Homo sapiens_hsa05131	0.52429732
81	Fatty acid metabolism_Homo sapiens_hsa01212	0.52171262
82	Glutathione metabolism_Homo sapiens_hsa00480	0.51148003
83	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.50214634
84	DNA replication_Homo sapiens_hsa03030	0.48103847
85	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.46970294
86	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.46944770
87	Rheumatoid arthritis_Homo sapiens_hsa05323	0.44928319
88	Pyruvate metabolism_Homo sapiens_hsa00620	0.44025782
89	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.40142092
90	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.40075210
91	Lysine degradation_Homo sapiens_hsa00310	0.37787808
92	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.36400356
93	Calcium signaling pathway_Homo sapiens_hsa04020	0.35998795
94	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.35397182
95	Retinol metabolism_Homo sapiens_hsa00830	0.35126622
96	Fat digestion and absorption_Homo sapiens_hsa04975	0.34919084
97	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.34373007
98	Nucleotide excision repair_Homo sapiens_hsa03420	0.33880838
99	Measles_Homo sapiens_hsa05162	0.33319753
100	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.31277562

ACTG1P10

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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