ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	protein-cofactor linkage (GO:0018065)	4.55336944
2	DNA deamination (GO:0045006)	4.34473007
3	L-fucose metabolic process (GO:0042354)	4.29151184
4	L-fucose catabolic process (GO:0042355)	4.29151184
5	fucose catabolic process (GO:0019317)	4.29151184
6	cullin deneddylation (GO:0010388)	4.19746536
7	protein deneddylation (GO:0000338)	4.03932296
8	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.97083437
9	NADH dehydrogenase complex assembly (GO:0010257)	3.97083437
10	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.97083437
11	protein neddylation (GO:0045116)	3.91717968
12	protein complex biogenesis (GO:0070271)	3.86445328
13	negative regulation of telomere maintenance (GO:0032205)	3.75743623
14	proteasome assembly (GO:0043248)	3.65352369
15	respiratory chain complex IV assembly (GO:0008535)	3.62009745
16	mitochondrial respiratory chain complex assembly (GO:0033108)	3.61480168
17	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.61239437
18	ATP synthesis coupled proton transport (GO:0015986)	3.55550550
19	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.55550550
20	water-soluble vitamin biosynthetic process (GO:0042364)	3.51526450
21	preassembly of GPI anchor in ER membrane (GO:0016254)	3.49419811
22	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.49413896
23	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.49413896
24	positive regulation of mitochondrial fission (GO:0090141)	3.42522420
25	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.38058273
26	amino acid salvage (GO:0043102)	3.28772658
27	L-methionine salvage (GO:0071267)	3.28772658
28	L-methionine biosynthetic process (GO:0071265)	3.28772658
29	GPI anchor metabolic process (GO:0006505)	3.27868795
30	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.24369125
31	regulation of cellular amino acid metabolic process (GO:0006521)	3.19433144
32	mannosylation (GO:0097502)	3.18580815
33	base-excision repair, AP site formation (GO:0006285)	3.16049904
34	protein polyglutamylation (GO:0018095)	3.14277070
35	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.12842566
36	cytochrome complex assembly (GO:0017004)	3.04887762
37	DNA damage response, detection of DNA damage (GO:0042769)	3.04780282
38	negative regulation of synaptic transmission, GABAergic (GO:0032229)	3.04661642
39	platelet dense granule organization (GO:0060155)	3.02480835
40	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.98700338
41	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.98623807
42	GPI anchor biosynthetic process (GO:0006506)	2.98421803
43	iron-sulfur cluster assembly (GO:0016226)	2.95090731
44	metallo-sulfur cluster assembly (GO:0031163)	2.95090731
45	piRNA metabolic process (GO:0034587)	2.93731304
46	regulation of isotype switching to IgG isotypes (GO:0048302)	2.92485682
47	aldehyde catabolic process (GO:0046185)	2.92470409
48	behavioral response to nicotine (GO:0035095)	2.89658293
49	DNA double-strand break processing (GO:0000729)	2.87860238
50	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.87475268
51	positive regulation of defense response to virus by host (GO:0002230)	2.85273443
52	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.82581768
53	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.82581768
54	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.82581768
55	ubiquinone biosynthetic process (GO:0006744)	2.82089890
56	electron transport chain (GO:0022900)	2.81543781
57	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.80487960
58	ubiquinone metabolic process (GO:0006743)	2.79882539
59	tRNA processing (GO:0008033)	2.79411563
60	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.78934077
61	respiratory electron transport chain (GO:0022904)	2.77709896
62	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.76506121
63	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.76222676
64	regulation of mitotic spindle checkpoint (GO:1903504)	2.76222676
65	C-terminal protein lipidation (GO:0006501)	2.75056377
66	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.74920750
67	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.74920750
68	maturation of 5.8S rRNA (GO:0000460)	2.69934115
69	protein localization to cilium (GO:0061512)	2.69850469
70	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.68911165
71	regulation of chronic inflammatory response (GO:0002676)	2.68509054
72	tRNA metabolic process (GO:0006399)	2.67705644
73	sequestering of actin monomers (GO:0042989)	2.66633794
74	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.65462594
75	isotype switching (GO:0045190)	2.65462594
76	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.65462594
77	pyrimidine nucleobase catabolic process (GO:0006208)	2.65099105
78	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.64550767
79	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.64550767
80	pseudouridine synthesis (GO:0001522)	2.64283803
81	gamma-aminobutyric acid transport (GO:0015812)	2.64204509
82	tRNA modification (GO:0006400)	2.63283109
83	termination of RNA polymerase III transcription (GO:0006386)	2.62878321
84	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.62878321
85	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.62728105
86	regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)	2.62360224
87	branched-chain amino acid catabolic process (GO:0009083)	2.61907716
88	C-terminal protein amino acid modification (GO:0018410)	2.61214602
89	DNA catabolic process, exonucleolytic (GO:0000738)	2.60925805
90	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.58293316
91	negative regulation of ligase activity (GO:0051352)	2.58293316
92	energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)	2.58254986
93	ATP hydrolysis coupled proton transport (GO:0015991)	2.58254986
94	peptidyl-histidine modification (GO:0018202)	2.52968499
95	regulation of immunoglobulin secretion (GO:0051023)	2.52709962
96	methionine biosynthetic process (GO:0009086)	2.51371574
97	regulation of mitochondrial fission (GO:0090140)	2.51334956
98	hydrogen ion transmembrane transport (GO:1902600)	2.48453920
99	proton transport (GO:0015992)	2.47849865
100	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.47385598

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.17133473
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.06791403
3	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.62100043
4	ZNF274_21170338_ChIP-Seq_K562_Hela	3.54008757
5	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.30933197
6	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.22851419
7	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.17840311
8	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.02273531
9	VDR_22108803_ChIP-Seq_LS180_Human	2.70912502
10	VDR_23849224_ChIP-Seq_CD4+_Human	2.67791314
11	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.59255787
12	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.57491113
13	ELK1_19687146_ChIP-ChIP_HELA_Human	2.35405392
14	IGF1R_20145208_ChIP-Seq_DFB_Human	2.32312222
15	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.21702492
16	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.11830438
17	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	2.07700933
18	FOXP3_21729870_ChIP-Seq_TREG_Human	2.07005957
19	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.03888656
20	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.03219752
21	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.02993625
22	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.02633696
23	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.98779324
24	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.94053011
25	MYC_18940864_ChIP-ChIP_HL60_Human	1.91717849
26	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.87239080
27	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.87076911
28	TAF15_26573619_Chip-Seq_HEK293_Human	1.84513635
29	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.77627580
30	GBX2_23144817_ChIP-Seq_PC3_Human	1.77054917
31	EWS_26573619_Chip-Seq_HEK293_Human	1.76332461
32	IRF1_19129219_ChIP-ChIP_H3396_Human	1.74157629
33	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.71104586
34	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.67384052
35	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.67313255
36	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.64086223
37	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.60865817
38	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.60045069
39	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.59976267
40	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.54583213
41	FUS_26573619_Chip-Seq_HEK293_Human	1.52392644
42	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.49831600
43	TP53_22573176_ChIP-Seq_HFKS_Human	1.48504435
44	GABP_19822575_ChIP-Seq_HepG2_Human	1.47935394
45	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.46715141
46	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.42209977
47	P300_19829295_ChIP-Seq_ESCs_Human	1.42001445
48	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.41970404
49	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.38217002
50	DCP1A_22483619_ChIP-Seq_HELA_Human	1.35642150
51	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.35400374
52	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.32432670
53	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.31815204
54	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.27518865
55	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.27118403
56	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.24920742
57	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.21953161
58	CBP_20019798_ChIP-Seq_JUKART_Human	1.21953161
59	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.20983082
60	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.20009542
61	ER_23166858_ChIP-Seq_MCF-7_Human	1.18464705
62	GATA3_26560356_Chip-Seq_TH2_Human	1.16833237
63	AR_20517297_ChIP-Seq_VCAP_Human	1.15361235
64	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.15344205
65	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.15344205
66	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.14929886
67	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.11825215
68	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.07930197
69	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.06046620
70	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.05915836
71	TTF2_22483619_ChIP-Seq_HELA_Human	1.05883684
72	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.05771543
73	NANOG_19829295_ChIP-Seq_ESCs_Human	1.05713469
74	SOX2_19829295_ChIP-Seq_ESCs_Human	1.05713469
75	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.04327860
76	NCOR_22424771_ChIP-Seq_293T_Human	1.03403314
77	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.02292508
78	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.02267249
79	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.01494802
80	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.00394807
81	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.99280375
82	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.98815350
83	MYC_18358816_ChIP-ChIP_MESCs_Mouse	0.97283906
84	CIITA_25753668_ChIP-Seq_RAJI_Human	0.94918913
85	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	0.91900357
86	HOXB7_26014856_ChIP-Seq_BT474_Human	0.91562655
87	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.91505958
88	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.91244899
89	THAP11_20581084_ChIP-Seq_MESCs_Mouse	0.90502274
90	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.90274818
91	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.90251369
92	MYC_18555785_ChIP-Seq_MESCs_Mouse	0.88641623
93	E2F1_18555785_ChIP-Seq_MESCs_Mouse	0.87472142
94	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.86380277
95	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	0.84747853
96	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.84145028
97	TCF4_22108803_ChIP-Seq_LS180_Human	0.82842648
98	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.81967535
99	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.81410599
100	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.81163556

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002102_abnormal_ear_morphology	3.08579268
2	MP0001529_abnormal_vocalization	2.85849548
3	MP0006072_abnormal_retinal_apoptosis	2.71603371
4	MP0008877_abnormal_DNA_methylation	2.55382158
5	MP0001835_abnormal_antigen_presentation	2.50123179
6	MP0005646_abnormal_pituitary_gland	2.49082982
7	MP0001984_abnormal_olfaction	2.33096212
8	MP0005084_abnormal_gallbladder_morpholo	2.28240632
9	MP0008875_abnormal_xenobiotic_pharmacok	2.23252311
10	MP0004147_increased_porphyrin_level	2.23095762
11	MP0005645_abnormal_hypothalamus_physiol	2.12405523
12	MP0002138_abnormal_hepatobiliary_system	2.08618124
13	MP0003195_calcinosis	2.06849500
14	MP0008058_abnormal_DNA_repair	2.01948305
15	MP0005671_abnormal_response_to	1.97954324
16	MP0003724_increased_susceptibility_to	1.94739607
17	MP0001968_abnormal_touch/_nociception	1.85943442
18	MP0002736_abnormal_nociception_after	1.85889525
19	MP0005551_abnormal_eye_electrophysiolog	1.85108731
20	MP0004142_abnormal_muscle_tone	1.77648212
21	MP0001501_abnormal_sleep_pattern	1.74220904
22	MP0005253_abnormal_eye_physiology	1.71614195
23	MP0009046_muscle_twitch	1.70955336
24	MP0006276_abnormal_autonomic_nervous	1.69800294
25	MP0001873_stomach_inflammation	1.67641659
26	MP0008995_early_reproductive_senescence	1.67186722
27	MP0003806_abnormal_nucleotide_metabolis	1.63797688
28	MP0002822_catalepsy	1.62946582
29	MP0008872_abnormal_physiological_respon	1.60232579
30	MP0002148_abnormal_hypersensitivity_rea	1.58939662
31	MP0003646_muscle_fatigue	1.58286762
32	MP0003011_delayed_dark_adaptation	1.53744517
33	MP0000569_abnormal_digit_pigmentation	1.53238025
34	MP0003880_abnormal_central_pattern	1.48631392
35	MP0009785_altered_susceptibility_to	1.46897696
36	MP0002272_abnormal_nervous_system	1.45989080
37	MP0001986_abnormal_taste_sensitivity	1.44909056
38	MP0003718_maternal_effect	1.43017020
39	MP0003786_premature_aging	1.40425099
40	MP0000685_abnormal_immune_system	1.39592230
41	MP0003787_abnormal_imprinting	1.37705342
42	MP0002837_dystrophic_cardiac_calcinosis	1.36990179
43	MP0000372_irregular_coat_pigmentation	1.36733200
44	MP0009745_abnormal_behavioral_response	1.36728794
45	MP0002751_abnormal_autonomic_nervous	1.33642689
46	MP0003186_abnormal_redox_activity	1.30017127
47	MP0003122_maternal_imprinting	1.29612857
48	MP0001905_abnormal_dopamine_level	1.29026764
49	MP0006036_abnormal_mitochondrial_physio	1.26514822
50	MP0005387_immune_system_phenotype	1.24346986
51	MP0001790_abnormal_immune_system	1.24346986
52	MP0009764_decreased_sensitivity_to	1.23154644
53	MP0001486_abnormal_startle_reflex	1.22433128
54	MP0005167_abnormal_blood-brain_barrier	1.20477605
55	MP0001800_abnormal_humoral_immune	1.16486087
56	MP0002876_abnormal_thyroid_physiology	1.13728570
57	MP0006035_abnormal_mitochondrial_morpho	1.12861158
58	MP0005000_abnormal_immune_tolerance	1.12398986
59	MP0002572_abnormal_emotion/affect_behav	1.11451218
60	MP0008789_abnormal_olfactory_epithelium	1.09082183
61	MP0002277_abnormal_respiratory_mucosa	1.05864807
62	MP0003121_genomic_imprinting	1.02228813
63	MP0005499_abnormal_olfactory_system	1.01649449
64	MP0005394_taste/olfaction_phenotype	1.01649449
65	MP0002557_abnormal_social/conspecific_i	0.99946988
66	MP0006292_abnormal_olfactory_placode	0.98061221
67	MP0002733_abnormal_thermal_nociception	0.97992160
68	MP0001764_abnormal_homeostasis	0.95599731
69	MP0001502_abnormal_circadian_rhythm	0.94574457
70	MP0002653_abnormal_ependyma_morphology	0.94466500
71	MP0004145_abnormal_muscle_electrophysio	0.92970957
72	MP0000631_abnormal_neuroendocrine_gland	0.91779256
73	MP0002638_abnormal_pupillary_reflex	0.89996041
74	MP0003567_abnormal_fetal_cardiomyocyte	0.89815556
75	MP0002723_abnormal_immune_serum	0.88689794
76	MP0008775_abnormal_heart_ventricle	0.86899258
77	MP0004742_abnormal_vestibular_system	0.85796001
78	MP0005410_abnormal_fertilization	0.84836713
79	MP0002735_abnormal_chemical_nociception	0.83356927
80	MP0005332_abnormal_amino_acid	0.81998987
81	MP0004215_abnormal_myocardial_fiber	0.80992961
82	MP0002064_seizures	0.80214565
83	MP0002452_abnormal_antigen_presenting	0.80210105
84	MP0003866_abnormal_defecation	0.79918512
85	MP0004885_abnormal_endolymph	0.78708526
86	MP0002234_abnormal_pharynx_morphology	0.77065026
87	MP0001970_abnormal_pain_threshold	0.76569527
88	MP0002063_abnormal_learning/memory/cond	0.74891094
89	MP0000427_abnormal_hair_cycle	0.74345211
90	MP0005075_abnormal_melanosome_morpholog	0.73917238
91	MP0003635_abnormal_synaptic_transmissio	0.73823721
92	MP0004782_abnormal_surfactant_physiolog	0.72563696
93	MP0000465_gastrointestinal_hemorrhage	0.72404656
94	MP0004924_abnormal_behavior	0.71473222
95	MP0005386_behavior/neurological_phenoty	0.71473222
96	MP0003252_abnormal_bile_duct	0.71315865
97	MP0005266_abnormal_metabolism	0.69070536
98	MP0001819_abnormal_immune_cell	0.68719857
99	MP0005636_abnormal_mineral_homeostasis	0.68257117
100	MP0002420_abnormal_adaptive_immunity	0.67763254

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	3.97284949
2	Mitochondrial inheritance (HP:0001427)	3.62777750
3	Abnormal mitochondria in muscle tissue (HP:0008316)	3.59995348
4	Acute encephalopathy (HP:0006846)	3.58527409
5	Increased CSF lactate (HP:0002490)	3.55671228
6	Hepatocellular necrosis (HP:0001404)	3.42067151
7	Progressive macrocephaly (HP:0004481)	3.34811701
8	Hepatic necrosis (HP:0002605)	3.29272112
9	Increased hepatocellular lipid droplets (HP:0006565)	3.27467167
10	Lipid accumulation in hepatocytes (HP:0006561)	3.19725598
11	Congenital stationary night blindness (HP:0007642)	3.08189940
12	Pancreatic cysts (HP:0001737)	3.06343376
13	3-Methylglutaconic aciduria (HP:0003535)	3.00281900
14	Increased serum lactate (HP:0002151)	2.91809481
15	Methylmalonic acidemia (HP:0002912)	2.88879365
16	Renal cortical cysts (HP:0000803)	2.82813368
17	IgG deficiency (HP:0004315)	2.82375833
18	Type II lissencephaly (HP:0007260)	2.77841995
19	Stomatitis (HP:0010280)	2.70470769
20	Abnormality of midbrain morphology (HP:0002418)	2.68729217
21	Molar tooth sign on MRI (HP:0002419)	2.68729217
22	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.68487900
23	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.68487900
24	Abolished electroretinogram (ERG) (HP:0000550)	2.64183251
25	Hypothermia (HP:0002045)	2.61943507
26	Abnormality of the renal cortex (HP:0011035)	2.60203098
27	Lactic acidosis (HP:0003128)	2.58067840
28	Nephronophthisis (HP:0000090)	2.57046041
29	Methylmalonic aciduria (HP:0012120)	2.54697646
30	True hermaphroditism (HP:0010459)	2.53704682
31	Lissencephaly (HP:0001339)	2.51229112
32	Cerebral edema (HP:0002181)	2.48286692
33	Congenital, generalized hypertrichosis (HP:0004540)	2.42399062
34	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.42258649
35	Medial flaring of the eyebrow (HP:0010747)	2.41737947
36	Optic disc pallor (HP:0000543)	2.41217007
37	Renal Fanconi syndrome (HP:0001994)	2.40969653
38	Progressive microcephaly (HP:0000253)	2.40627195
39	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.39059081
40	Exertional dyspnea (HP:0002875)	2.37966459
41	Increased intramyocellular lipid droplets (HP:0012240)	2.37943845
42	Pancreatic fibrosis (HP:0100732)	2.36413632
43	Retinal dysplasia (HP:0007973)	2.32840216
44	Abnormality of the labia minora (HP:0012880)	2.32234887
45	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.30018951
46	Pendular nystagmus (HP:0012043)	2.29682623
47	Generalized aminoaciduria (HP:0002909)	2.28422027
48	Inability to walk (HP:0002540)	2.24541608
49	Severe combined immunodeficiency (HP:0004430)	2.21319784
50	Abnormality of the renal medulla (HP:0100957)	2.16617400
51	Elevated erythrocyte sedimentation rate (HP:0003565)	2.15988428
52	Progressive inability to walk (HP:0002505)	2.13245604
53	Delayed CNS myelination (HP:0002188)	2.12290367
54	Degeneration of anterior horn cells (HP:0002398)	2.11879312
55	Abnormality of the anterior horn cell (HP:0006802)	2.11879312
56	Aplasia/hypoplasia of the uterus (HP:0008684)	2.10922328
57	Stomach cancer (HP:0012126)	2.07694042
58	Respiratory failure (HP:0002878)	2.07286296
59	Hyperglycinemia (HP:0002154)	2.07074115
60	Hyperglycinuria (HP:0003108)	2.06511713
61	Short tibia (HP:0005736)	2.05337130
62	Lethargy (HP:0001254)	2.05125262
63	Failure to thrive in infancy (HP:0001531)	2.04472409
64	Polyphagia (HP:0002591)	2.04146355
65	Abnormal protein glycosylation (HP:0012346)	2.03977953
66	Abnormal glycosylation (HP:0012345)	2.03977953
67	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.03977953
68	Abnormal protein N-linked glycosylation (HP:0012347)	2.03977953
69	Type I transferrin isoform profile (HP:0003642)	2.03810723
70	Increased corneal curvature (HP:0100692)	2.01906366
71	Keratoconus (HP:0000563)	2.01906366
72	Increased muscle lipid content (HP:0009058)	1.98383006
73	Attenuation of retinal blood vessels (HP:0007843)	1.95832311
74	Abnormality of glycine metabolism (HP:0010895)	1.93885137
75	Abnormality of serine family amino acid metabolism (HP:0010894)	1.93885137
76	Thyroiditis (HP:0100646)	1.93425253
77	Abnormality of urine glucose concentration (HP:0011016)	1.92312031
78	Glycosuria (HP:0003076)	1.92312031
79	Cerebral hypomyelination (HP:0006808)	1.89970626
80	Fibular aplasia (HP:0002990)	1.89528568
81	Nephrogenic diabetes insipidus (HP:0009806)	1.88849430
82	Humeroradial synostosis (HP:0003041)	1.86728382
83	Synostosis involving the elbow (HP:0003938)	1.86728382
84	Exercise intolerance (HP:0003546)	1.85225469
85	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.83750599
86	Gait imbalance (HP:0002141)	1.80829920
87	Colon cancer (HP:0003003)	1.80406645
88	Abnormality of the prostate (HP:0008775)	1.79970339
89	Congenital primary aphakia (HP:0007707)	1.79921881
90	Ketoacidosis (HP:0001993)	1.79846616
91	Large for gestational age (HP:0001520)	1.78203007
92	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.76949227
93	Abnormality of alanine metabolism (HP:0010916)	1.76949227
94	Hyperalaninemia (HP:0003348)	1.76949227
95	Ketosis (HP:0001946)	1.76585078
96	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.75932365
97	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.75234131
98	CNS demyelination (HP:0007305)	1.74961386
99	Abnormal drinking behavior (HP:0030082)	1.73754934
100	Polydipsia (HP:0001959)	1.73754934

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	4.10496708
2	TAOK3	3.93108409
3	TLK1	2.80947252
4	BCKDK	2.79012305
5	ZAK	2.78883600
6	TXK	2.64608394
7	TSSK6	2.64249933
8	TRIM28	2.56263695
9	BCR	2.23057954
10	NUAK1	2.10674355
11	ADRBK2	2.00329932
12	VRK2	1.97556019
13	BMPR1B	1.84361684
14	CSNK1G3	1.83778292
15	SRPK1	1.81585436
16	GRK1	1.75262634
17	PINK1	1.73191632
18	EIF2AK3	1.69200239
19	WNK3	1.65202794
20	CSNK1A1L	1.64810858
21	CSNK1G1	1.58605718
22	CSNK1G2	1.53923047
23	MAPKAPK3	1.48782798
24	EPHA3	1.43745480
25	FRK	1.41340522
26	MAP3K4	1.33412031
27	VRK1	1.29199141
28	TIE1	1.26820323
29	DYRK2	1.23652487
30	TESK2	1.23646133
31	WNK4	1.18895899
32	MAP3K12	1.18010138
33	OXSR1	1.17605333
34	INSRR	1.14026435
35	CDK19	1.13008742
36	STK16	1.11308572
37	MAP2K7	1.07510113
38	SIK3	1.07437602
39	MKNK1	1.06636825
40	PLK2	1.06622483
41	MST4	1.06508098
42	RPS6KA4	1.05164686
43	KIT	1.01185410
44	NME1	0.98302863
45	PLK3	0.96877570
46	MAPK13	0.96517215
47	DAPK1	0.92975015
48	BUB1	0.92321754
49	MAP2K6	0.90497262
50	NEK1	0.88391671
51	RPS6KA5	0.86214823
52	ERBB3	0.84569840
53	PAK6	0.82615882
54	MINK1	0.82463586
55	PHKG2	0.78568128
56	PHKG1	0.78568128
57	FLT3	0.77755427
58	TEC	0.76580749
59	IKBKB	0.75018873
60	PAK3	0.73874167
61	PRKCE	0.73154762
62	FES	0.71284164
63	SYK	0.68902710
64	BMPR2	0.68836638
65	MAP4K1	0.68338291
66	TGFBR1	0.63034910
67	KDR	0.60774554
68	GRK5	0.60769806
69	EIF2AK2	0.59726438
70	MARK1	0.59000489
71	ITK	0.56039771
72	PRKCG	0.54309965
73	CDK8	0.53962079
74	GRK7	0.53866992
75	DAPK2	0.51175803
76	ADRBK1	0.50479053
77	MKNK2	0.49520407
78	LIMK1	0.49190269
79	PBK	0.47333310
80	CSNK1A1	0.46951979
81	CCNB1	0.46131073
82	MAP2K2	0.45071830
83	TNK2	0.44616549
84	EIF2AK1	0.41259878
85	MAPKAPK5	0.40190734
86	CAMK2A	0.39078851
87	GRK6	0.38818000
88	LYN	0.38380215
89	IKBKE	0.37191041
90	IGF1R	0.36557825
91	TNIK	0.35392637
92	PLK4	0.34935895
93	LCK	0.34527741
94	ATR	0.34350216
95	CSNK2A1	0.34162204
96	TBK1	0.31394796
97	PTK2B	0.29440568
98	PRKCQ	0.28582505
99	STK39	0.28504248
100	SIK2	0.28196866

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	3.91813229
2	Protein export_Homo sapiens_hsa03060	3.31093690
3	Oxidative phosphorylation_Homo sapiens_hsa00190	3.13135318
4	Asthma_Homo sapiens_hsa05310	2.70292989
5	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.62345631
6	Parkinsons disease_Homo sapiens_hsa05012	2.58094130
7	RNA polymerase_Homo sapiens_hsa03020	2.28559529
8	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.26386669
9	Phototransduction_Homo sapiens_hsa04744	2.11746632
10	Allograft rejection_Homo sapiens_hsa05330	2.01812626
11	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.99502967
12	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.85941982
13	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.81251526
14	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.74165100
15	Type I diabetes mellitus_Homo sapiens_hsa04940	1.67254560
16	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.65875576
17	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.64730226
18	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.59775851
19	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.59163765
20	RNA degradation_Homo sapiens_hsa03018	1.56331611
21	Propanoate metabolism_Homo sapiens_hsa00640	1.52204382
22	Huntingtons disease_Homo sapiens_hsa05016	1.51328481
23	Basal transcription factors_Homo sapiens_hsa03022	1.47413468
24	Alzheimers disease_Homo sapiens_hsa05010	1.46112413
25	One carbon pool by folate_Homo sapiens_hsa00670	1.43140433
26	Primary immunodeficiency_Homo sapiens_hsa05340	1.41908454
27	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.41641766
28	Butanoate metabolism_Homo sapiens_hsa00650	1.41124807
29	Graft-versus-host disease_Homo sapiens_hsa05332	1.39152009
30	Regulation of autophagy_Homo sapiens_hsa04140	1.33402560
31	Non-homologous end-joining_Homo sapiens_hsa03450	1.27607126
32	Selenocompound metabolism_Homo sapiens_hsa00450	1.24241805
33	Collecting duct acid secretion_Homo sapiens_hsa04966	1.23150120
34	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.23006740
35	Linoleic acid metabolism_Homo sapiens_hsa00591	1.21628262
36	Rheumatoid arthritis_Homo sapiens_hsa05323	1.21025368
37	Fatty acid elongation_Homo sapiens_hsa00062	1.16442505
38	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.13645951
39	Base excision repair_Homo sapiens_hsa03410	1.12802800
40	Peroxisome_Homo sapiens_hsa04146	1.10507519
41	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.10317298
42	Spliceosome_Homo sapiens_hsa03040	1.09913416
43	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.09206436
44	Antigen processing and presentation_Homo sapiens_hsa04612	1.07271826
45	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.02101818
46	RNA transport_Homo sapiens_hsa03013	1.01610407
47	Nicotine addiction_Homo sapiens_hsa05033	1.00544649
48	Cardiac muscle contraction_Homo sapiens_hsa04260	0.99999447
49	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.99208520
50	Purine metabolism_Homo sapiens_hsa00230	0.98577640
51	Fanconi anemia pathway_Homo sapiens_hsa03460	0.96392059
52	Pyrimidine metabolism_Homo sapiens_hsa00240	0.95509937
53	Caffeine metabolism_Homo sapiens_hsa00232	0.95210541
54	Sulfur metabolism_Homo sapiens_hsa00920	0.93204018
55	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.92748917
56	Nitrogen metabolism_Homo sapiens_hsa00910	0.92716194
57	Tryptophan metabolism_Homo sapiens_hsa00380	0.91896771
58	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.83277277
59	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.81914615
60	Ether lipid metabolism_Homo sapiens_hsa00565	0.81083166
61	GABAergic synapse_Homo sapiens_hsa04727	0.77948616
62	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.77577277
63	Homologous recombination_Homo sapiens_hsa03440	0.75819159
64	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.75578634
65	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.74211921
66	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.73774499
67	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.69144864
68	Metabolic pathways_Homo sapiens_hsa01100	0.69058973
69	Steroid biosynthesis_Homo sapiens_hsa00100	0.68558927
70	Ribosome_Homo sapiens_hsa03010	0.68049462
71	Taste transduction_Homo sapiens_hsa04742	0.64660260
72	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.63290260
73	Morphine addiction_Homo sapiens_hsa05032	0.61600868
74	Chemical carcinogenesis_Homo sapiens_hsa05204	0.60512972
75	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.58027594
76	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.53957365
77	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.53036992
78	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.53011137
79	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.51221491
80	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.49398492
81	Olfactory transduction_Homo sapiens_hsa04740	0.48201813
82	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.48037285
83	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.48020151
84	Vibrio cholerae infection_Homo sapiens_hsa05110	0.47908876
85	Mismatch repair_Homo sapiens_hsa03430	0.47698005
86	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.46867074
87	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.44670505
88	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.42920630
89	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.42105302
90	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.41943668
91	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.41385495
92	beta-Alanine metabolism_Homo sapiens_hsa00410	0.40439995
93	Viral myocarditis_Homo sapiens_hsa05416	0.40218001
94	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.36930617
95	Retinol metabolism_Homo sapiens_hsa00830	0.36168639
96	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.35406119
97	Carbon metabolism_Homo sapiens_hsa01200	0.34229235
98	Nucleotide excision repair_Homo sapiens_hsa03420	0.33062041
99	Serotonergic synapse_Homo sapiens_hsa04726	0.32447698
100	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.32406504

ACTG1P11

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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