ACTG1P12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fat-soluble vitamin catabolic process (GO:0042363)9.95024635
2vitamin catabolic process (GO:0009111)9.95024635
3regulation of female receptivity (GO:0045924)9.41360104
4mature B cell differentiation involved in immune response (GO:0002313)8.92825568
5female mating behavior (GO:0060180)8.15807528
6negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)7.07009418
7mature B cell differentiation (GO:0002335)6.82007760
8phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)6.73451644
9positive regulation of inositol phosphate biosynthetic process (GO:0060732)6.17231948
10detection of light stimulus involved in visual perception (GO:0050908)5.75425164
11detection of light stimulus involved in sensory perception (GO:0050962)5.75425164
12synaptic transmission, dopaminergic (GO:0001963)5.63827008
13cellular glucuronidation (GO:0052695)5.40008530
14lipoxygenase pathway (GO:0019372)5.36990372
15protein targeting to vacuole (GO:0006623)5.30687259
16protein targeting to lysosome (GO:0006622)5.30687259
17establishment of protein localization to vacuole (GO:0072666)5.30687259
18adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)5.23461127
19response to gravity (GO:0009629)5.20656575
20glucuronate metabolic process (GO:0019585)5.08437660
21uronic acid metabolic process (GO:0006063)5.08437660
22polarized epithelial cell differentiation (GO:0030859)5.03132860
23skeletal muscle adaptation (GO:0043501)4.91612030
24embryonic heart tube development (GO:0035050)4.88195830
25regulation of inositol phosphate biosynthetic process (GO:0010919)4.86495947
26morphogenesis of an endothelium (GO:0003159)4.84653001
27endothelial tube morphogenesis (GO:0061154)4.84653001
28negative regulation of oxidoreductase activity (GO:0051354)4.82972268
29striated muscle atrophy (GO:0014891)4.76768447
30positive regulation of cAMP-mediated signaling (GO:0043950)4.74841742
31muscle filament sliding (GO:0030049)4.61403009
32actin-myosin filament sliding (GO:0033275)4.61403009
33coenzyme catabolic process (GO:0009109)4.59892014
34lymphangiogenesis (GO:0001946)4.54860258
35regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.52709760
36pantothenate metabolic process (GO:0015939)4.51924761
37long term synaptic depression (GO:0060292)4.31487086
38glycosphingolipid biosynthetic process (GO:0006688)4.30578546
39regulation of MHC class II biosynthetic process (GO:0045346)4.29978108
40GTP biosynthetic process (GO:0006183)4.22298658
41neuronal action potential (GO:0019228)4.20383624
42regulation of sensory perception of pain (GO:0051930)4.20030904
43regulation of sensory perception (GO:0051931)4.20030904
44ATP synthesis coupled proton transport (GO:0015986)4.19167672
45energy coupled proton transport, down electrochemical gradient (GO:0015985)4.19167672
46muscle atrophy (GO:0014889)4.10749040
47protein localization to vacuole (GO:0072665)4.07418642
48protein localization to lysosome (GO:0061462)4.07418642
49receptor guanylyl cyclase signaling pathway (GO:0007168)4.02128693
50tissue regeneration (GO:0042246)3.99292308
51regulation of germinal center formation (GO:0002634)3.87402479
52regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.83525248
53DNA deamination (GO:0045006)3.69583375
54actin-mediated cell contraction (GO:0070252)3.65036385
55transmission of nerve impulse (GO:0019226)3.62294348
56positive regulation of calcium-mediated signaling (GO:0050850)3.61699687
57primary amino compound metabolic process (GO:1901160)3.59063325
58UTP biosynthetic process (GO:0006228)3.58016708
59collecting duct development (GO:0072044)3.57595287
60protein polyglutamylation (GO:0018095)3.54116832
61pericardium development (GO:0060039)3.50421956
62positive regulation of chemokine secretion (GO:0090197)3.47749225
63positive regulation of macrophage derived foam cell differentiation (GO:0010744)3.43671656
64venous blood vessel morphogenesis (GO:0048845)3.40577751
65positive regulation of phosphatase activity (GO:0010922)3.38140706
66mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.36217879
67positive regulation of macrophage differentiation (GO:0045651)3.34010918
68nonmotile primary cilium assembly (GO:0035058)3.27417355
69UTP metabolic process (GO:0046051)3.26063129
70regulation of macrophage chemotaxis (GO:0010758)3.20852031
71regulation of megakaryocyte differentiation (GO:0045652)3.18374386
72response to muscle activity (GO:0014850)3.18149260
73regulation of skeletal muscle contraction (GO:0014819)3.17596314
74B cell activation involved in immune response (GO:0002312)3.15484894
75membrane depolarization during action potential (GO:0086010)3.15472338
76positive regulation of interleukin-8 secretion (GO:2000484)3.12937457
77endothelial cell development (GO:0001885)3.12177156
78multicellular organismal reproductive behavior (GO:0033057)3.11123029
79regulation of mesoderm development (GO:2000380)3.03965016
80basic amino acid transport (GO:0015802)3.03221112
81indolalkylamine metabolic process (GO:0006586)2.99900187
82positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.97150644
83kynurenine metabolic process (GO:0070189)2.95737489
84leukocyte tethering or rolling (GO:0050901)2.94941543
85negative regulation of muscle hypertrophy (GO:0014741)2.93106185
86activation of adenylate cyclase activity (GO:0007190)2.92464967
87apical protein localization (GO:0045176)2.91867826
88negative regulation of monooxygenase activity (GO:0032769)2.91507517
89response to amphetamine (GO:0001975)2.90198779
90L-fucose metabolic process (GO:0042354)2.89982723
91L-fucose catabolic process (GO:0042355)2.89982723
92fucose catabolic process (GO:0019317)2.89982723
93regulation of chemokine secretion (GO:0090196)2.89910867
94serotonin metabolic process (GO:0042428)2.88134631
95cGMP biosynthetic process (GO:0006182)2.84534776
96regulation of calcium-mediated signaling (GO:0050848)2.82806707
97adenosine metabolic process (GO:0046085)2.82335934
98glycosylceramide metabolic process (GO:0006677)2.78285971
99sleep (GO:0030431)2.77626439
100skeletal muscle tissue regeneration (GO:0043403)11.1088254

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.68523626
2NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.24360882
3VDR_22108803_ChIP-Seq_LS180_Human3.16613296
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.98059209
5LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.97898256
6IRF8_22096565_ChIP-ChIP_GC-B_Human2.92425297
7EED_16625203_ChIP-ChIP_MESCs_Mouse2.91519807
8GBX2_23144817_ChIP-Seq_PC3_Human2.58692134
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.56534438
10ZFP57_27257070_Chip-Seq_ESCs_Mouse2.48974025
11EZH2_22144423_ChIP-Seq_EOC_Human2.44669794
12STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.36157958
13FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.17557977
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.17372936
15CTBP2_25329375_ChIP-Seq_LNCAP_Human2.17251352
16KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.09137346
17KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.09137346
18KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.09137346
19TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.05776721
20EWS_26573619_Chip-Seq_HEK293_Human2.03981932
21FUS_26573619_Chip-Seq_HEK293_Human2.00619881
22JARID2_20064375_ChIP-Seq_MESCs_Mouse1.97183428
23ESR1_20079471_ChIP-ChIP_T-47D_Human1.96535550
24TDRD3_21172665_ChIP-Seq_MCF-7_Human1.96192491
25PCGF2_27294783_Chip-Seq_ESCs_Mouse1.95461422
26BCAT_22108803_ChIP-Seq_LS180_Human1.94910129
27CTBP1_25329375_ChIP-Seq_LNCAP_Human1.94610488
28RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.93568691
29POU3F2_20337985_ChIP-ChIP_501MEL_Human1.86965297
30POU5F1_16153702_ChIP-ChIP_HESCs_Human1.84285832
31NCOR_22424771_ChIP-Seq_293T_Human1.69432674
32JARID2_20075857_ChIP-Seq_MESCs_Mouse1.66394950
33ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.65392768
34HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.62623374
35CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.62043571
36SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.57483033
37SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.56761252
38SMAD3_21741376_ChIP-Seq_EPCs_Human1.55239318
39BMI1_23680149_ChIP-Seq_NPCS_Mouse1.54007569
40AUTS2_25519132_ChIP-Seq_293T-REX_Human1.50671558
41UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.50634291
42TP53_22573176_ChIP-Seq_HFKS_Human1.50242035
43LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.49625754
44GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.47101224
45SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.46698954
46SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.45425045
47CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.44787742
48ARNT_22903824_ChIP-Seq_MCF-7_Human1.44490887
49CBX2_27304074_Chip-Seq_ESCs_Mouse1.42432177
50PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.40732447
51PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.40248202
52CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.38949073
53DROSHA_22980978_ChIP-Seq_HELA_Human1.34479804
54FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.33840275
55STAT3_23295773_ChIP-Seq_U87_Human1.32837418
56SMAD4_21799915_ChIP-Seq_A2780_Human1.31668669
57EZH2_27304074_Chip-Seq_ESCs_Mouse1.31238560
58RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.30174742
59FLI1_21867929_ChIP-Seq_TH2_Mouse1.29558298
60IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.27841387
61ER_23166858_ChIP-Seq_MCF-7_Human1.26967855
62P53_21459846_ChIP-Seq_SAOS-2_Human1.26372660
63SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.24780782
64IKZF1_21737484_ChIP-ChIP_HCT116_Human1.21745221
65TAF15_26573619_Chip-Seq_HEK293_Human1.20252906
66EZH2_18974828_ChIP-Seq_MESCs_Mouse1.19510072
67RNF2_18974828_ChIP-Seq_MESCs_Mouse1.19510072
68CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.19394133
69SOX2_21211035_ChIP-Seq_LN229_Human1.18921172
70IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.18708771
71CBP_20019798_ChIP-Seq_JUKART_Human1.18708771
72AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.17773102
73GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.16469315
74P300_19829295_ChIP-Seq_ESCs_Human1.16268464
75PCGF2_27294783_Chip-Seq_NPCs_Mouse1.15980071
76TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.15845710
77TCF4_23295773_ChIP-Seq_U87_Human1.15599043
78TP53_20018659_ChIP-ChIP_R1E_Mouse1.13559667
79EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.10080016
80POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.08276597
81TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08276597
82RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08017660
83PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.07219471
84THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.04187046
85SMAD4_21741376_ChIP-Seq_EPCs_Human1.03792487
86SUZ12_27294783_Chip-Seq_NPCs_Mouse1.03552364
87RAC3_21632823_ChIP-Seq_H3396_Human1.02616283
88TAF2_19829295_ChIP-Seq_ESCs_Human1.02426371
89BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.01888968
90MYC_19829295_ChIP-Seq_ESCs_Human1.01130689
91IRF8_27001747_Chip-Seq_BMDM_Mouse1.00773734
92GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.99450238
93EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.98929963
94PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.97833640
95YY1_21170310_ChIP-Seq_MESCs_Mouse0.97324894
96CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.94929645
97REST_21632747_ChIP-Seq_MESCs_Mouse0.94692595
98FOXH1_21741376_ChIP-Seq_EPCs_Human0.92925696
99FOXA1_21572438_ChIP-Seq_LNCaP_Human0.92099162
100HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.91150837

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002653_abnormal_ependyma_morphology8.86181707
2MP0002736_abnormal_nociception_after6.58818370
3MP0001968_abnormal_touch/_nociception5.02549675
4MP0005360_urolithiasis4.47627515
5MP0005409_darkened_coat_color4.29949921
6MP0005083_abnormal_biliary_tract3.54235733
7MP0009697_abnormal_copulation3.23478266
8MP0003172_abnormal_lysosome_physiology3.19386835
9MP0009840_abnormal_foam_cell3.12079323
10MP0006276_abnormal_autonomic_nervous2.85605125
11MP0002909_abnormal_adrenal_gland2.80083915
12MP0000678_abnormal_parathyroid_gland2.74228882
13MP0004145_abnormal_muscle_electrophysio2.38942210
14MP0002734_abnormal_mechanical_nocicepti2.37813747
15MP0003646_muscle_fatigue2.33873155
16MP0002277_abnormal_respiratory_mucosa2.16309469
17MP0003724_increased_susceptibility_to1.75486043
18MP0001879_abnormal_lymphatic_vessel1.70246024
19MP0002928_abnormal_bile_duct1.58589925
20MP0005646_abnormal_pituitary_gland1.55261654
21MP0000747_muscle_weakness1.53983394
22MP0003950_abnormal_plasma_membrane1.53136831
23MP0001873_stomach_inflammation1.47739310
24MP0002148_abnormal_hypersensitivity_rea1.33898519
25MP0004036_abnormal_muscle_relaxation1.32076237
26MP0009053_abnormal_anal_canal1.28497637
27MP0005671_abnormal_response_to1.26362277
28MP0006072_abnormal_retinal_apoptosis1.22312127
29MP0002108_abnormal_muscle_morphology1.21650515
30MP0004742_abnormal_vestibular_system1.18841871
31MP0001984_abnormal_olfaction1.15730669
32MP0001970_abnormal_pain_threshold1.15352166
33MP0003136_yellow_coat_color1.10049400
34MP0002837_dystrophic_cardiac_calcinosis1.05162194
35MP0002933_joint_inflammation1.05078625
36MP0000049_abnormal_middle_ear1.04629529
37MP0003938_abnormal_ear_development1.04147432
38MP0004130_abnormal_muscle_cell1.02959813
39MP0000631_abnormal_neuroendocrine_gland0.98376400
40MP0009250_abnormal_appendicular_skeleto0.94915212
41MP0006292_abnormal_olfactory_placode0.94379225
42MP0002089_abnormal_postnatal_growth/wei0.93355629
43MP0002282_abnormal_trachea_morphology0.93090659
44MP0000537_abnormal_urethra_morphology0.93024309
45MP0008789_abnormal_olfactory_epithelium0.92927946
46MP0000467_abnormal_esophagus_morphology0.92569558
47MP0003119_abnormal_digestive_system0.92186817
48MP0000749_muscle_degeneration0.91504177
49MP0002098_abnormal_vibrissa_morphology0.86661730
50MP0002269_muscular_atrophy0.86091718
51MP0003718_maternal_effect0.83440937
52MP0002127_abnormal_cardiovascular_syste0.83319459
53MP0008872_abnormal_physiological_respon0.80439260
54MP0002735_abnormal_chemical_nociception0.79856287
55MP0000759_abnormal_skeletal_muscle0.79360969
56MP0002272_abnormal_nervous_system0.77767265
57MP0003195_calcinosis0.76302214
58MP0002896_abnormal_bone_mineralization0.75308057
59MP0000230_abnormal_systemic_arterial0.72035487
60MP0001502_abnormal_circadian_rhythm0.71289434
61MP0002102_abnormal_ear_morphology0.68057066
62MP0004085_abnormal_heartbeat0.67832688
63MP0000470_abnormal_stomach_morphology0.67119722
64MP0002138_abnormal_hepatobiliary_system0.65253118
65MP0005551_abnormal_eye_electrophysiolog0.64533672
66MP0005253_abnormal_eye_physiology0.63878587
67MP0003252_abnormal_bile_duct0.63576084
68MP0005084_abnormal_gallbladder_morpholo0.63375654
69MP0002106_abnormal_muscle_physiology0.63118403
70MP0001963_abnormal_hearing_physiology0.61766274
71MP0000372_irregular_coat_pigmentation0.61266330
72MP0000534_abnormal_ureter_morphology0.60968378
73MP0003959_abnormal_lean_body0.60810833
74MP0005369_muscle_phenotype0.60615786
75MP0010771_integument_phenotype0.57946351
76MP0004381_abnormal_hair_follicle0.57126238
77MP0000465_gastrointestinal_hemorrhage0.56025258
78MP0002249_abnormal_larynx_morphology0.55027473
79MP0004087_abnormal_muscle_fiber0.54765027
80MP0000613_abnormal_salivary_gland0.53477919
81MP0003937_abnormal_limbs/digits/tail_de0.52663522
82MP0002733_abnormal_thermal_nociception0.52559204
83MP0005620_abnormal_muscle_contractility0.51921776
84MP0000516_abnormal_urinary_system0.50534574
85MP0005367_renal/urinary_system_phenotyp0.50534574
86MP0001800_abnormal_humoral_immune0.49227555
87MP0001485_abnormal_pinna_reflex0.48583391
88MP0000026_abnormal_inner_ear0.48219713
89MP0000538_abnormal_urinary_bladder0.48177603
90MP0002572_abnormal_emotion/affect_behav0.46114991
91MP0005000_abnormal_immune_tolerance0.45876546
92MP0000249_abnormal_blood_vessel0.44673073
93MP0004885_abnormal_endolymph0.44573480
94MP0009745_abnormal_behavioral_response0.44332498
95MP0003879_abnormal_hair_cell0.42421350
96MP0002075_abnormal_coat/hair_pigmentati0.41625417
97MP0005394_taste/olfaction_phenotype0.41309012
98MP0005499_abnormal_olfactory_system0.41309012
99MP0004859_abnormal_synaptic_plasticity0.40427797
100MP0000377_abnormal_hair_follicle0.40368362

Predicted human phenotypes

RankGene SetZ-score
1Dynein arm defect of respiratory motile cilia (HP:0012255)6.91975569
2Absent/shortened dynein arms (HP:0200106)6.91975569
3Absent phalangeal crease (HP:0006109)6.07135588
4Abnormality of cochlea (HP:0000375)5.67285406
5Distal arthrogryposis (HP:0005684)5.41941532
6Ulnar deviation of the wrist (HP:0003049)5.37896150
7Failure to thrive in infancy (HP:0001531)5.25030294
8Round ear (HP:0100830)5.23115257
9Abnormal finger flexion creases (HP:0006143)5.17125057
10Decreased central vision (HP:0007663)5.10125847
11Dysautonomia (HP:0002459)4.92619362
12Poor head control (HP:0002421)4.65608784
13Calcaneovalgus deformity (HP:0001848)4.54167111
14Morphological abnormality of the inner ear (HP:0011390)4.44127597
15Keratoconjunctivitis sicca (HP:0001097)4.41746824
16Abolished electroretinogram (ERG) (HP:0000550)4.41571167
17Deformed tarsal bones (HP:0008119)4.24498909
18Tinnitus (HP:0000360)4.24054923
19Constricted visual fields (HP:0001133)4.19324323
20Keratoconjunctivitis (HP:0001096)4.16816604
21Bony spicule pigmentary retinopathy (HP:0007737)4.04205824
22Abnormality of aspartate family amino acid metabolism (HP:0010899)3.93131412
23Follicular hyperkeratosis (HP:0007502)3.77938814
24Abnormal respiratory motile cilium morphology (HP:0005938)3.72756698
25Abnormal respiratory epithelium morphology (HP:0012253)3.72756698
26Attenuation of retinal blood vessels (HP:0007843)3.60554005
27Generalized aminoaciduria (HP:0002909)3.54026338
28Lymphangioma (HP:0100764)3.46072251
29Abnormal ciliary motility (HP:0012262)3.36153810
30Morphological abnormality of the middle ear (HP:0008609)3.27304936
31Palpebral edema (HP:0100540)3.22701345
32Nemaline bodies (HP:0003798)3.15470507
33Abnormality of the costochondral junction (HP:0000919)3.11989295
34Keratoconus (HP:0000563)3.10163058
35Increased corneal curvature (HP:0100692)3.10163058
36Abnormality of the proximal phalanges of the hand (HP:0009834)3.04936959
37Cone-rod dystrophy (HP:0000548)2.97706244
38Decreased electroretinogram (ERG) amplitude (HP:0000654)2.94744967
39Nonimmune hydrops fetalis (HP:0001790)2.92803767
40Abnormal autonomic nervous system physiology (HP:0012332)2.85337395
41Recurrent sinusitis (HP:0011108)2.80217224
42Impaired pain sensation (HP:0007328)2.67139109
43Abnormality of pain sensation (HP:0010832)2.67139109
44Absent eyebrow (HP:0002223)2.57592980
45Muscle fiber inclusion bodies (HP:0100299)2.51884277
46Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.50842568
47Abnormal respiratory motile cilium physiology (HP:0012261)2.46083547
48Abnormality of the peritoneum (HP:0002585)2.43940850
49B lymphocytopenia (HP:0010976)2.40862065
50Stenosis of the external auditory canal (HP:0000402)2.38082952
51Chest pain (HP:0100749)2.32855343
52Abnormality of the renal collecting system (HP:0004742)2.30994256
53Periorbital edema (HP:0100539)2.30853924
54Congenital stationary night blindness (HP:0007642)2.28894306
55Absent eyelashes (HP:0000561)2.22101553
56Abnormality of the middle phalanges of the toes (HP:0010183)2.19529676
57Symphalangism affecting the phalanges of the hand (HP:0009773)2.19164922
58Facial edema (HP:0000282)2.18091633
59Mesangial abnormality (HP:0001966)2.17961930
60Mask-like facies (HP:0000298)2.17132277
61Abnormality of the calcaneus (HP:0008364)2.16316509
62Progressive microcephaly (HP:0000253)2.15787336
63Abnormality of the nasal septum (HP:0000419)2.15037718
64Long nose (HP:0003189)2.09547159
65Exercise-induced myalgia (HP:0003738)2.08543969
66Thyroiditis (HP:0100646)2.07332392
67Abnormality of B cell number (HP:0010975)2.03903904
68Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.03834965
69Hypotrichosis (HP:0001006)2.00487437
70Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.99578260
71Enlarged epiphyses (HP:0010580)1.95703992
72Pustule (HP:0200039)1.95080555
73Mesomelia (HP:0003027)1.94177963
74Keratitis (HP:0000491)1.93726749
75Lip pit (HP:0100267)1.93347272
76Tarsal synostosis (HP:0008368)1.91222173
77Short 1st metacarpal (HP:0010034)1.87996521
78Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.87996521
79Synostosis involving the elbow (HP:0003938)1.87296125
80Humeroradial synostosis (HP:0003041)1.87296125
81Ulnar deviation of finger (HP:0009465)1.86574095
82Abnormality of the phalanges of the 5th finger (HP:0004213)1.86398483
83Abnormality of glutamine family amino acid metabolism (HP:0010902)1.85387336
84Delayed epiphyseal ossification (HP:0002663)1.84744755
85Amaurosis fugax (HP:0100576)1.80415041
86Severe combined immunodeficiency (HP:0004430)1.80384492
87Short hallux (HP:0010109)1.80323175
88Thin bony cortex (HP:0002753)1.76182365
89Neoplasm of the heart (HP:0100544)1.76128607
90Synostosis involving bones of the feet (HP:0009140)1.75364530
91Synostosis involving bones of the lower limbs (HP:0009138)1.75364530
92Down-sloping shoulders (HP:0200021)1.74874992
93Type 1 muscle fiber predominance (HP:0003803)1.73819032
94Short tibia (HP:0005736)1.73481670
95Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.73474975
96Photophobia (HP:0000613)1.72667446
97Arterial thrombosis (HP:0004420)1.72281785
98Vertigo (HP:0002321)1.70923951
99Congenital, generalized hypertrichosis (HP:0004540)1.69716001
100Autoimmune thrombocytopenia (HP:0001973)1.68381549

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP2K24.66178417
2NUAK13.85268327
3TAOK33.75894176
4ZAK3.59193638
5CDK43.10024069
6GRK12.98934603
7MAP4K22.72810320
8TIE12.63778335
9VRK22.58182239
10OBSCN2.52924593
11STK382.44981555
12TXK2.16541229
13FRK2.14734982
14CAMKK21.99517557
15CHEK21.92236831
16TAF11.91609575
17PHKG21.83321749
18PHKG11.83321749
19MAP2K11.79771167
20TLK11.79476145
21PIK3CA1.76974568
22BMPR1B1.76035099
23CSNK1G31.66879651
24CSNK1A1L1.54566821
25KDR1.50563100
26VRK11.42837825
27CSNK1G11.42722162
28ADRBK21.36780554
29CAMK1D1.34691946
30DAPK11.33097149
31WNK41.26872712
32CSNK1G21.21747522
33MYLK1.11889567
34CDK121.11806572
35JAK31.04246539
36MUSK1.01188426
37PIK3CG0.98534995
38GRK50.89046943
39INSRR0.88299993
40PINK10.83961027
41MAPK130.81126884
42PAK40.78887486
43TEC0.75823182
44AURKA0.75139320
45MAP4K10.74428372
46SYK0.72942029
47MAP3K120.72011353
48PLK20.71919980
49TESK20.69784423
50IKBKB0.67152108
51PTK2B0.66324429
52ZAP700.66305901
53CCNB10.65275472
54MAPK40.64716833
55MAPK150.63026781
56MAPKAPK50.62568030
57GRK60.62279002
58CAMK10.61994709
59CAMK2B0.59823142
60CAMK2G0.56550308
61CDK60.55896651
62RIPK40.54189752
63PRKCZ0.50038151
64OXSR10.48339055
65ERBB20.45972237
66WNK30.45911995
67CAMK1G0.45091304
68PRKCA0.43140610
69CSNK1A10.43012698
70PRKCQ0.41960430
71KIT0.41673564
72ITK0.41318939
73PIM10.40172167
74RPS6KA50.39974993
75PLK30.39356658
76PTK20.38984362
77ILK0.37928091
78MAP3K110.37691699
79STK390.37662672
80IRAK10.37567925
81PRKCE0.37198524
82LCK0.37077972
83BLK0.36202077
84MST40.36005693
85MAP2K60.35992258
86PRKACA0.35251774
87MAPKAPK30.34649115
88LYN0.32217267
89MAPKAPK20.31736707
90BCKDK0.30445030
91SMG10.30046910
92CAMKK10.29178086
93DAPK30.27298897
94PRKCB0.27167735
95IKBKE0.27132790
96CSNK2A10.27089063
97ABL20.26707945
98BTK0.26406338
99ADRBK10.25959297
100CAMK2A0.25572891

Predicted pathways (KEGG)

RankGene SetZ-score
1Ascorbate and aldarate metabolism_Homo sapiens_hsa000534.19479092
2Sulfur metabolism_Homo sapiens_hsa009203.48946067
3Pentose and glucuronate interconversions_Homo sapiens_hsa000403.31391022
4Intestinal immune network for IgA production_Homo sapiens_hsa046723.05393387
5Olfactory transduction_Homo sapiens_hsa047403.02491025
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.93138066
7Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.63007250
8Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.61293615
9Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.54069431
10Steroid hormone biosynthesis_Homo sapiens_hsa001402.51399772
11Phototransduction_Homo sapiens_hsa047442.48478505
12Starch and sucrose metabolism_Homo sapiens_hsa005002.42377671
13Retinol metabolism_Homo sapiens_hsa008302.37160663
14Chemical carcinogenesis_Homo sapiens_hsa052042.35873915
15Drug metabolism - other enzymes_Homo sapiens_hsa009832.30277773
16Asthma_Homo sapiens_hsa053102.08995072
17Histidine metabolism_Homo sapiens_hsa003401.90891040
18Sulfur relay system_Homo sapiens_hsa041221.85085313
19Primary immunodeficiency_Homo sapiens_hsa053401.72611277
20Homologous recombination_Homo sapiens_hsa034401.57408508
21Allograft rejection_Homo sapiens_hsa053301.57128333
22SNARE interactions in vesicular transport_Homo sapiens_hsa041301.51014121
23Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.50620800
24Autoimmune thyroid disease_Homo sapiens_hsa053201.50049053
25Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.49324988
26Arachidonic acid metabolism_Homo sapiens_hsa005901.43274522
27Ether lipid metabolism_Homo sapiens_hsa005651.39724449
28Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.36837538
29Oxidative phosphorylation_Homo sapiens_hsa001901.29601256
30Renin secretion_Homo sapiens_hsa049241.25910050
31Systemic lupus erythematosus_Homo sapiens_hsa053221.22353266
32Graft-versus-host disease_Homo sapiens_hsa053321.19669333
33Parkinsons disease_Homo sapiens_hsa050121.19371405
34Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.15900405
35Calcium signaling pathway_Homo sapiens_hsa040201.15656539
36Nitrogen metabolism_Homo sapiens_hsa009101.15276770
37Alzheimers disease_Homo sapiens_hsa050101.14964365
38Circadian entrainment_Homo sapiens_hsa047131.03436310
39Cardiac muscle contraction_Homo sapiens_hsa042601.01687654
40Taste transduction_Homo sapiens_hsa047420.99352119
41Tryptophan metabolism_Homo sapiens_hsa003800.97527005
42Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.91837483
43Protein digestion and absorption_Homo sapiens_hsa049740.91451554
44Gastric acid secretion_Homo sapiens_hsa049710.88501694
45Ribosome_Homo sapiens_hsa030100.85942624
46Type I diabetes mellitus_Homo sapiens_hsa049400.85726513
47Nicotine addiction_Homo sapiens_hsa050330.85437750
48Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.83406414
49beta-Alanine metabolism_Homo sapiens_hsa004100.81839799
50Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.81375034
51ABC transporters_Homo sapiens_hsa020100.78329387
52Tight junction_Homo sapiens_hsa045300.76470732
53Insulin secretion_Homo sapiens_hsa049110.76213289
54Legionellosis_Homo sapiens_hsa051340.74762508
55RNA polymerase_Homo sapiens_hsa030200.69432652
56Arginine and proline metabolism_Homo sapiens_hsa003300.69429132
57Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.68703016
58RNA degradation_Homo sapiens_hsa030180.68648498
59Proteasome_Homo sapiens_hsa030500.61108424
60Hematopoietic cell lineage_Homo sapiens_hsa046400.59580928
61Rheumatoid arthritis_Homo sapiens_hsa053230.59499307
62Viral myocarditis_Homo sapiens_hsa054160.56434695
63cAMP signaling pathway_Homo sapiens_hsa040240.53709667
64Dopaminergic synapse_Homo sapiens_hsa047280.52344895
65Maturity onset diabetes of the young_Homo sapiens_hsa049500.51022028
66Staphylococcus aureus infection_Homo sapiens_hsa051500.50998914
67Mismatch repair_Homo sapiens_hsa034300.49941685
68NF-kappa B signaling pathway_Homo sapiens_hsa040640.49089973
69Lysine degradation_Homo sapiens_hsa003100.47688798
70Glutathione metabolism_Homo sapiens_hsa004800.47559240
71Protein export_Homo sapiens_hsa030600.46385608
72Huntingtons disease_Homo sapiens_hsa050160.44052472
73Purine metabolism_Homo sapiens_hsa002300.43429605
74Oxytocin signaling pathway_Homo sapiens_hsa049210.43365708
75Morphine addiction_Homo sapiens_hsa050320.41197361
76DNA replication_Homo sapiens_hsa030300.40222627
77Aldosterone synthesis and secretion_Homo sapiens_hsa049250.38582099
78Serotonergic synapse_Homo sapiens_hsa047260.36996237
79NOD-like receptor signaling pathway_Homo sapiens_hsa046210.36870251
80Regulation of autophagy_Homo sapiens_hsa041400.36278091
81Vascular smooth muscle contraction_Homo sapiens_hsa042700.34107529
82Basal cell carcinoma_Homo sapiens_hsa052170.32647766
83Antigen processing and presentation_Homo sapiens_hsa046120.32617589
84Metabolic pathways_Homo sapiens_hsa011000.30204643
85Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.29991877
86Collecting duct acid secretion_Homo sapiens_hsa049660.29862813
87Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.29484154
88Caffeine metabolism_Homo sapiens_hsa002320.29415805
89T cell receptor signaling pathway_Homo sapiens_hsa046600.29121124
90Hedgehog signaling pathway_Homo sapiens_hsa043400.28407956
91Salivary secretion_Homo sapiens_hsa049700.27588599
92Peroxisome_Homo sapiens_hsa041460.27257095
93Steroid biosynthesis_Homo sapiens_hsa001000.27020586
94Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.23875848
95Fanconi anemia pathway_Homo sapiens_hsa034600.23795143
96Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.22699670
97Glycerolipid metabolism_Homo sapiens_hsa005610.22524259
98Linoleic acid metabolism_Homo sapiens_hsa005910.17374204
99Dilated cardiomyopathy_Homo sapiens_hsa054140.16535749
100Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.16382834

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