ACTG1P14

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)6.43599847
2epithelial cell maturation (GO:0002070)6.14155523
3DNA deamination (GO:0045006)5.50998409
4regulation of cell-cell adhesion mediated by cadherin (GO:2000047)5.35708525
5regulation of cell proliferation involved in kidney development (GO:1901722)5.01160512
6cellular response to antibiotic (GO:0071236)4.70194330
7epithelial cell differentiation involved in prostate gland development (GO:0060742)4.49182691
8regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.38341695
9regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)4.25468350
10positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO4.25468350
11cytidine catabolic process (GO:0006216)4.05896618
12cytidine deamination (GO:0009972)4.05896618
13cytidine metabolic process (GO:0046087)4.05896618
14peptidyl-threonine dephosphorylation (GO:0035970)4.01197080
15hepatocyte apoptotic process (GO:0097284)3.98450773
16negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.91400835
17dorsal/ventral neural tube patterning (GO:0021904)3.70724778
18omega-hydroxylase P450 pathway (GO:0097267)3.60014159
19positive regulation of mRNA catabolic process (GO:0061014)3.57905586
20positive regulation of defense response to virus by host (GO:0002230)3.55528972
21CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.55188854
22T-helper cell differentiation (GO:0042093)3.55188854
23cellular response to toxic substance (GO:0097237)3.47752101
24xenobiotic catabolic process (GO:0042178)3.44253603
25pyrimidine ribonucleoside catabolic process (GO:0046133)3.40524144
26regulation of cellular amino acid metabolic process (GO:0006521)3.36913705
27exocrine pancreas development (GO:0031017)3.32277726
28interferon-gamma secretion (GO:0072643)3.31285728
29DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.28029634
30T cell differentiation involved in immune response (GO:0002292)3.23015011
31alpha-beta T cell differentiation involved in immune response (GO:0002293)3.23015011
32alpha-beta T cell activation involved in immune response (GO:0002287)3.23015011
33platelet dense granule organization (GO:0060155)3.22476153
34norepinephrine metabolic process (GO:0042415)3.20055202
35cellular response to interleukin-15 (GO:0071350)3.17472126
36positive regulation of hair cycle (GO:0042635)3.15610432
37positive regulation of hair follicle development (GO:0051798)3.15610432
38diterpenoid biosynthetic process (GO:0016102)3.15321373
39signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.14608013
40signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.14608013
41signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.14608013
42mitotic cell cycle arrest (GO:0071850)3.14059197
43intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.14017802
44signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.14017802
45negative T cell selection (GO:0043383)3.11384616
46regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.11301378
47positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.09587347
48GTP biosynthetic process (GO:0006183)3.07583296
49signal transduction involved in DNA damage checkpoint (GO:0072422)3.02078957
50signal transduction involved in DNA integrity checkpoint (GO:0072401)3.02078957
51signal transduction involved in cell cycle checkpoint (GO:0072395)2.98658358
52metallo-sulfur cluster assembly (GO:0031163)2.97510700
53iron-sulfur cluster assembly (GO:0016226)2.97510700
54positive regulation of interleukin-4 production (GO:0032753)2.96278071
55tooth mineralization (GO:0034505)2.93618857
56regulation of mesenchymal cell apoptotic process (GO:2001053)2.93140884
57negative regulation of epidermal cell differentiation (GO:0045605)2.92914112
58positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.92205096
59regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.91774207
60prostate gland epithelium morphogenesis (GO:0060740)2.91068848
61negative regulation of epithelial to mesenchymal transition (GO:0010719)2.89652017
62regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.87754426
63thymic T cell selection (GO:0045061)2.85917900
64endoderm formation (GO:0001706)2.85232068
65negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.84858113
66RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.84594341
67tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.84594341
68lateral ventricle development (GO:0021670)2.84223622
69peptidyl-arginine omega-N-methylation (GO:0035247)2.82858077
70regulation of mRNA catabolic process (GO:0061013)2.80711782
71regulation of memory T cell differentiation (GO:0043380)2.78731990
72keratinocyte development (GO:0003334)2.78148577
73Arp2/3 complex-mediated actin nucleation (GO:0034314)2.75904600
74actin nucleation (GO:0045010)2.73579759
75positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.72400913
76toxin metabolic process (GO:0009404)2.71885544
77positive regulation of cell fate commitment (GO:0010455)2.71820378
78T cell receptor signaling pathway (GO:0050852)2.71330549
79terpenoid biosynthetic process (GO:0016114)2.71018801
80regulation of T cell receptor signaling pathway (GO:0050856)2.69214803
81neuron fate specification (GO:0048665)2.68672697
82regulation of interleukin-13 production (GO:0032656)2.68149118
83negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.67719434
84negative regulation of ligase activity (GO:0051352)2.67719434
85decidualization (GO:0046697)2.65446360
86proteasome assembly (GO:0043248)2.64031162
87epoxygenase P450 pathway (GO:0019373)2.62874093
88positive regulation of alpha-beta T cell proliferation (GO:0046641)2.61393750
89negative thymic T cell selection (GO:0045060)2.60220129
90negative regulation of multicellular organism growth (GO:0040015)2.60197491
91positive T cell selection (GO:0043368)2.60018270
92positive regulation of T cell mediated cytotoxicity (GO:0001916)2.59802484
93negative regulation of transcription regulatory region DNA binding (GO:2000678)2.59764438
94sequestering of actin monomers (GO:0042989)2.59725132
95regulation of defense response to virus by host (GO:0050691)2.59650192
96mesonephros development (GO:0001823)2.57326358
97T cell differentiation (GO:0030217)2.56822990
98regulation of interleukin-4 production (GO:0032673)2.56527065
99antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.55841912
100regulation of regulatory T cell differentiation (GO:0045589)2.54812543

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_21235772_ChIP-Seq_MCF-7_Human4.96577699
2ESR1_15608294_ChIP-ChIP_MCF-7_Human4.86928737
3NOTCH1_21737748_ChIP-Seq_TLL_Human4.73711051
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.46250483
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.41906336
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.35190431
7ELF1_17652178_ChIP-ChIP_JURKAT_Human3.15234513
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.08196668
9IRF8_22096565_ChIP-ChIP_GC-B_Human2.98660220
10ZNF263_19887448_ChIP-Seq_K562_Human2.80772505
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.74694404
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.62600551
13SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.60406295
14IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.55355333
15ESR2_21235772_ChIP-Seq_MCF-7_Human2.49369641
16HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.49009621
17JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.46807726
18VDR_23849224_ChIP-Seq_CD4+_Human2.37552221
19TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.37305166
20RUNX_20019798_ChIP-Seq_JUKART_Human2.36487698
21ZNF274_21170338_ChIP-Seq_K562_Hela2.36254405
22FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.33609877
23BP1_19119308_ChIP-ChIP_Hs578T_Human2.22452555
24ESR1_20079471_ChIP-ChIP_T-47D_Human2.22091457
25FOXP3_21729870_ChIP-Seq_TREG_Human2.03948185
26ER_23166858_ChIP-Seq_MCF-7_Human1.97547029
27PADI4_21655091_ChIP-ChIP_MCF-7_Human1.90695952
28ETS1_20019798_ChIP-Seq_JURKAT_Human1.88821939
29IRF8_21731497_ChIP-ChIP_J774_Mouse1.87485741
30MYB_26560356_Chip-Seq_TH2_Human1.85660231
31CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.82515385
32CREB1_15753290_ChIP-ChIP_HEK293T_Human1.81519974
33ELK1_19687146_ChIP-ChIP_HELA_Human1.79846384
34SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.78515740
35STAT4_19710469_ChIP-ChIP_TH1__Mouse1.73849517
36TP63_19390658_ChIP-ChIP_HaCaT_Human1.72741274
37SRF_21415370_ChIP-Seq_HL-1_Mouse1.64838998
38E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.62708463
39TDRD3_21172665_ChIP-Seq_MCF-7_Human1.60394349
40HIF1A_21447827_ChIP-Seq_MCF-7_Human1.57927387
41MYC_18940864_ChIP-ChIP_HL60_Human1.55888946
42MYB_26560356_Chip-Seq_TH1_Human1.50974840
43IRF1_19129219_ChIP-ChIP_H3396_Human1.46592876
44GATA3_26560356_Chip-Seq_TH2_Human1.46257433
45GATA3_27048872_Chip-Seq_THYMUS_Human1.45389542
46DCP1A_22483619_ChIP-Seq_HELA_Human1.43957610
47PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.43850462
48PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.43730079
49VDR_22108803_ChIP-Seq_LS180_Human1.42271782
50HOXB4_20404135_ChIP-ChIP_EML_Mouse1.41781538
51PKCTHETA_26484144_Chip-Seq_BREAST_Human1.38385664
52LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.37802906
53CIITA_25753668_ChIP-Seq_RAJI_Human1.34597332
54EGR1_23403033_ChIP-Seq_LIVER_Mouse1.34086519
55IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.33780680
56AHR_22903824_ChIP-Seq_MCF-7_Human1.32343938
57TP53_22573176_ChIP-Seq_HFKS_Human1.31019446
58RNF2_27304074_Chip-Seq_NSC_Mouse1.30375210
59HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.29781215
60KDM5A_27292631_Chip-Seq_BREAST_Human1.26105897
61HOXB7_26014856_ChIP-Seq_BT474_Human1.25815576
62TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.25577389
63PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25096915
64FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.23156372
65STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.22658716
66EWS_26573619_Chip-Seq_HEK293_Human1.20091144
67ELF5_23300383_ChIP-Seq_T47D_Human1.18820393
68MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.17946744
69CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.16362559
70EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.15532566
71SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.15013421
72RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.13422934
73FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.12135435
74FLI1_27457419_Chip-Seq_LIVER_Mouse1.10673160
75BMI1_23680149_ChIP-Seq_NPCS_Mouse1.08905354
76STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.06883396
77BCAT_22108803_ChIP-Seq_LS180_Human1.05751039
78GABP_19822575_ChIP-Seq_HepG2_Human1.03601307
79SPI1_23547873_ChIP-Seq_NB4_Human1.02362057
80MAF_26560356_Chip-Seq_TH1_Human1.01631760
81YY1_21170310_ChIP-Seq_MESCs_Mouse1.01267086
82ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.01050826
83ERA_21632823_ChIP-Seq_H3396_Human0.99547136
84CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.98770806
85MYC_18358816_ChIP-ChIP_MESCs_Mouse0.97278914
86FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95832012
87CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.94851689
88MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.93767862
89FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.93400942
90FOXA1_27270436_Chip-Seq_PROSTATE_Human0.92995686
91FOXA1_25329375_ChIP-Seq_VCAP_Human0.92995686
92E2F1_18555785_ChIP-Seq_MESCs_Mouse0.92774088
93FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.86921909
94MYC_19030024_ChIP-ChIP_MESCs_Mouse0.86308539
95RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.85651796
96AR_20517297_ChIP-Seq_VCAP_Human0.82947400
97PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.81852666
98POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.81752556
99GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.81154614
100FOXM1_26456572_ChIP-Seq_MCF-7_Human0.80846175

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to3.78225909
2MP0002009_preneoplasia3.62967105
3MP0002909_abnormal_adrenal_gland3.52255088
4MP0000579_abnormal_nail_morphology3.34290908
5MP0002166_altered_tumor_susceptibility3.02759332
6MP0002098_abnormal_vibrissa_morphology2.96945161
7MP0001835_abnormal_antigen_presentation2.84964931
8MP0004264_abnormal_extraembryonic_tissu2.75183170
9MP0008875_abnormal_xenobiotic_pharmacok2.66404684
10MP0005075_abnormal_melanosome_morpholog2.66359914
11MP0008872_abnormal_physiological_respon2.61676890
12MP0003763_abnormal_thymus_physiology2.53606313
13MP0000465_gastrointestinal_hemorrhage2.52859240
14MP0003878_abnormal_ear_physiology2.35404446
15MP0005377_hearing/vestibular/ear_phenot2.35404446
16MP0004381_abnormal_hair_follicle2.34546421
17MP0002006_tumorigenesis2.23405606
18MP0001800_abnormal_humoral_immune2.15236842
19MP0000372_irregular_coat_pigmentation2.08330393
20MP0009278_abnormal_bone_marrow2.01670858
21MP0005000_abnormal_immune_tolerance1.90651467
22MP0003195_calcinosis1.88820340
23MP0001529_abnormal_vocalization1.87737636
24MP0002736_abnormal_nociception_after1.83445390
25MP0009785_altered_susceptibility_to1.78624262
26MP0002876_abnormal_thyroid_physiology1.72418051
27MP0002452_abnormal_antigen_presenting1.67923670
28MP0001968_abnormal_touch/_nociception1.67920334
29MP0005646_abnormal_pituitary_gland1.64080284
30MP0006292_abnormal_olfactory_placode1.62517540
31MP0002148_abnormal_hypersensitivity_rea1.59902083
32MP0002723_abnormal_immune_serum1.59164864
33MP0002420_abnormal_adaptive_immunity1.57873185
34MP0001819_abnormal_immune_cell1.57620218
35MP0003866_abnormal_defecation1.56676341
36MP0008995_early_reproductive_senescence1.56172985
37MP0005220_abnormal_exocrine_pancreas1.54338816
38MP0000703_abnormal_thymus_morphology1.52362968
39MP0005025_abnormal_response_to1.50996898
40MP0001919_abnormal_reproductive_system1.46570717
41MP0002398_abnormal_bone_marrow1.40871331
42MP0001542_abnormal_bone_strength1.37132349
43MP0000627_abnormal_mammary_gland1.32676975
44MP0000716_abnormal_immune_system1.32508395
45MP0003638_abnormal_response/metabolism_1.28155098
46MP0000689_abnormal_spleen_morphology1.28035326
47MP0001790_abnormal_immune_system1.25630357
48MP0005387_immune_system_phenotype1.25630357
49MP0003724_increased_susceptibility_to1.22377628
50MP0002102_abnormal_ear_morphology1.19268548
51MP0005084_abnormal_gallbladder_morpholo1.18074409
52MP0009780_abnormal_chondrocyte_physiolo1.17368552
53MP0010329_abnormal_lipoprotein_level1.17242863
54MP0003786_premature_aging1.16799265
55MP0000685_abnormal_immune_system1.13346829
56MP0005645_abnormal_hypothalamus_physiol1.09457096
57MP0002429_abnormal_blood_cell1.08545846
58MP0009333_abnormal_splenocyte_physiolog1.08445864
59MP0001243_abnormal_dermal_layer1.06938168
60MP0009764_decreased_sensitivity_to1.05515226
61MP0002722_abnormal_immune_system1.05303327
62MP0000015_abnormal_ear_pigmentation1.03789300
63MP0006072_abnormal_retinal_apoptosis1.03663236
64MP0004142_abnormal_muscle_tone1.02517041
65MP0003646_muscle_fatigue0.99437564
66MP0000427_abnormal_hair_cycle0.97621563
67MP0003936_abnormal_reproductive_system0.94793244
68MP0002693_abnormal_pancreas_physiology0.94210346
69MP0001727_abnormal_embryo_implantation0.90436272
70MP0001853_heart_inflammation0.88190832
71MP0001845_abnormal_inflammatory_respons0.84594325
72MP0001340_abnormal_eyelid_morphology0.78756652
73MP0004133_heterotaxia0.78554024
74MP0002019_abnormal_tumor_incidence0.78383074
75MP0005551_abnormal_eye_electrophysiolog0.77457260
76MP0008873_increased_physiological_sensi0.76304608
77MP0000383_abnormal_hair_follicle0.74248340
78MP0005253_abnormal_eye_physiology0.74061324
79MP0005389_reproductive_system_phenotype0.72085231
80MP0002419_abnormal_innate_immunity0.70595148
81MP0000639_abnormal_adrenal_gland0.69178283
82MP0006036_abnormal_mitochondrial_physio0.68812845
83MP0010155_abnormal_intestine_physiology0.68260354
84MP0008877_abnormal_DNA_methylation0.67130170
85MP0005083_abnormal_biliary_tract0.63728942
86MP0003806_abnormal_nucleotide_metabolis0.63503116
87MP0006276_abnormal_autonomic_nervous0.63419447
88MP0005647_abnormal_sex_gland0.63244931
89MP0004147_increased_porphyrin_level0.62912039
90MP0002160_abnormal_reproductive_system0.62352682
91MP0004130_abnormal_muscle_cell0.61896196
92MP0002277_abnormal_respiratory_mucosa0.61212183
93MP0004484_altered_response_of0.60733258
94MP0001764_abnormal_homeostasis0.59180269
95MP0001533_abnormal_skeleton_physiology0.58859929
96MP0006035_abnormal_mitochondrial_morpho0.58133090
97MP0000367_abnormal_coat/_hair0.57869969
98MP0001119_abnormal_female_reproductive0.57211007
99MP0005367_renal/urinary_system_phenotyp0.57144755
100MP0000516_abnormal_urinary_system0.57144755

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of lateral ventricle (HP:0030047)8.70599628
2IgG deficiency (HP:0004315)4.10524856
3Septate vagina (HP:0001153)4.06280189
4Elevated erythrocyte sedimentation rate (HP:0003565)3.91216223
5Abnormality of the parietal bone (HP:0002696)3.66754014
6Hypotrichosis (HP:0001006)3.66414017
7Hypoplasia of the brainstem (HP:0002365)3.41815947
8Aplasia/Hypoplasia of the brainstem (HP:0007362)3.41815947
9Optic nerve hypoplasia (HP:0000609)3.10150077
10Stomatitis (HP:0010280)3.05837462
11Abnormality of dental color (HP:0011073)2.99839909
12Intellectual disability, profound (HP:0002187)2.99732650
13Abnormality of T cell number (HP:0011839)2.89514207
14T lymphocytopenia (HP:0005403)2.85851454
15Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.82662548
16Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.78425972
17Decreased activity of mitochondrial respiratory chain (HP:0008972)2.78425972
18Aplasia cutis congenita (HP:0001057)2.74959492
19Increased IgM level (HP:0003496)2.68086085
20Abnormality of the phalanges of the 2nd finger (HP:0009541)2.65822364
21Abnormality of T cells (HP:0002843)2.62901598
22Severe combined immunodeficiency (HP:0004430)2.58814777
23Breast carcinoma (HP:0003002)2.46988189
243-Methylglutaconic aciduria (HP:0003535)2.46889979
25Panhypogammaglobulinemia (HP:0003139)2.45029686
26Congenital stationary night blindness (HP:0007642)2.42130993
27Hepatocellular necrosis (HP:0001404)2.41600207
28Hypoproteinemia (HP:0003075)2.41244708
29Short clavicles (HP:0000894)2.40293712
30Hepatic necrosis (HP:0002605)2.38796379
31Abnormality of the 2nd finger (HP:0004100)2.36514815
32Mitochondrial inheritance (HP:0001427)2.35730636
33Increased CSF lactate (HP:0002490)2.34686621
34Abnormality of the prostate (HP:0008775)2.34052948
35Abnormality of eosinophils (HP:0001879)2.31303251
36Increased serum lactate (HP:0002151)2.28466893
37Neonatal respiratory distress (HP:0002643)2.22818011
38Abnormal delayed hypersensitivity skin test (HP:0002963)2.18078649
39Aplasia/Hypoplasia of the clavicles (HP:0006710)2.17721195
40Wrist flexion contracture (HP:0001239)2.16368467
41Prostate neoplasm (HP:0100787)2.16187873
42Abnormality of T cell physiology (HP:0011840)2.14338688
43Absent frontal sinuses (HP:0002688)2.12939849
44Aplasia/Hypoplasia of the uvula (HP:0010293)2.11071419
45Depressed nasal tip (HP:0000437)2.10688108
46Polymicrogyria (HP:0002126)2.10461227
47Abnormality of B cell number (HP:0010975)2.10417705
48Absent rod-and cone-mediated responses on ERG (HP:0007688)2.08949163
49Metaphyseal dysplasia (HP:0100255)2.08725545
50Chronic diarrhea (HP:0002028)2.06204420
51Aplastic anemia (HP:0001915)2.05951941
52Increased intramyocellular lipid droplets (HP:0012240)2.05763611
53Abolished electroretinogram (ERG) (HP:0000550)2.05758772
54Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.05564033
55Widely patent fontanelles and sutures (HP:0004492)2.03811498
56Abnormality of the frontal sinuses (HP:0002687)2.01703521
57Concave nail (HP:0001598)10.1471714
58Thyroiditis (HP:0100646)1.99924592
59Eosinophilia (HP:0001880)1.99362720
60Hyperalaninemia (HP:0003348)1.97505007
61Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.97505007
62Abnormality of alanine metabolism (HP:0010916)1.97505007
63Encephalitis (HP:0002383)1.97117150
64Abnormal mitochondria in muscle tissue (HP:0008316)1.96283472
65Agammaglobulinemia (HP:0004432)1.95523701
66Renal cortical cysts (HP:0000803)1.95226796
67Acute necrotizing encephalopathy (HP:0006965)1.92916835
68Parakeratosis (HP:0001036)1.91907303
69Myositis (HP:0100614)1.89380899
70Stomach cancer (HP:0012126)1.87904559
71Autoimmune hemolytic anemia (HP:0001890)1.86799166
72Meckel diverticulum (HP:0002245)1.86254581
73Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.86167890
74Lipid accumulation in hepatocytes (HP:0006561)1.84930074
75Abnormal rod and cone electroretinograms (HP:0008323)1.84877999
76Recurrent cutaneous fungal infections (HP:0011370)1.84815398
77Chronic mucocutaneous candidiasis (HP:0002728)1.84815398
78Abnormality of male internal genitalia (HP:0000022)1.84684300
79Tongue fasciculations (HP:0001308)1.84155569
80Abnormality of the ileum (HP:0001549)1.82387369
81Optic neuritis (HP:0100653)1.81906514
82Retrobulbar optic neuritis (HP:0100654)1.81906514
83Attenuation of retinal blood vessels (HP:0007843)1.80441504
84Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.80206198
85Increased hepatocellular lipid droplets (HP:0006565)1.79840886
86Methylmalonic acidemia (HP:0002912)1.78428669
87Abnormality of the pons (HP:0007361)1.77805292
88Short middle phalanx of the 5th finger (HP:0004220)1.77598490
89Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.73118833
90Albinism (HP:0001022)1.72074901
91Increased muscle lipid content (HP:0009058)1.71949599
92Lactic acidosis (HP:0003128)1.71835088
93Combined immunodeficiency (HP:0005387)1.71087738
94Pancreatic cysts (HP:0001737)1.69939359
95Acute encephalopathy (HP:0006846)1.68134127
96B lymphocytopenia (HP:0010976)1.65573840
97Amelogenesis imperfecta (HP:0000705)1.65376918
98Abnormality of the phalanges of the 5th finger (HP:0004213)1.65290557
99Hypothermia (HP:0002045)1.65067320
100Pendular nystagmus (HP:0012043)1.62839075

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK24.11521879
2EPHA23.73879787
3PIM23.47889811
4TXK3.21413388
5TAOK33.19137968
6TRIM283.15513853
7MAP4K22.47435467
8VRK22.45341434
9MST42.16791289
10MAP3K122.10839832
11TLK12.07490824
12MUSK2.03286616
13SCYL21.88958003
14NUAK11.80361318
15EIF2AK31.71957076
16IKBKB1.71078565
17KDR1.70821858
18GRK61.69637729
19VRK11.65630665
20ZAK1.59721045
21MAPKAPK31.57935326
22MAP4K11.52112585
23BMPR21.47668370
24TESK11.46408835
25EIF2AK11.42016507
26PIM11.39781467
27EPHA31.39136932
28BUB11.35156737
29PIK3CA1.31649805
30ADRBK21.31464329
31RAF11.26331903
32GRK11.26109637
33HIPK21.25648786
34MAP2K21.23808934
35EIF2AK21.19776981
36IKBKE1.19609983
37CHUK1.14509296
38LIMK11.13939325
39RPS6KB21.01447100
40BCKDK1.00080732
41MAP2K70.99185400
42TAF10.98996684
43ITK0.97567412
44TEC0.96244582
45CSF1R0.92487072
46CDK60.88936742
47YES10.85842774
48SRPK10.83970419
49PINK10.82897671
50TNK20.82679859
51UHMK10.81783740
52TSSK60.78394526
53BMPR1B0.77217819
54FES0.76589941
55ADRBK10.76272875
56OXSR10.75137267
57ERBB30.74582953
58CDK80.74392175
59FRK0.74184142
60TBK10.73273177
61CLK10.69298127
62MAP3K140.67819469
63MAPK150.67190308
64SYK0.67060039
65RPS6KA60.66890162
66WNK30.66232701
67MAP2K10.65676403
68RPS6KC10.65546338
69RPS6KL10.65546338
70DYRK1B0.64774306
71JAK10.60688303
72NEK10.60607289
73PASK0.57479343
74LYN0.56844957
75MYLK0.54326692
76CSK0.52057155
77LCK0.51984693
78MAPKAPK20.48801487
79TIE10.47474402
80DAPK10.45548562
81CDK70.45298018
82PRKCI0.44970084
83PRKCE0.43580923
84NME10.43554822
85MAPK130.42367158
86RPS6KA50.41550184
87PRKCQ0.41274468
88ABL10.39416061
89MAP3K30.38828844
90SIK10.37984352
91DYRK20.37836715
92ATR0.37456828
93BTK0.36547613
94CCNB10.33902734
95AURKA0.32983714
96PRKCD0.32854837
97ILK0.31506700
98MAP3K90.30999034
99CSNK1A10.30810988
100PHKG20.29535281

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.54138331
2Primary immunodeficiency_Homo sapiens_hsa053403.60722145
3Allograft rejection_Homo sapiens_hsa053303.14772060
4Pathogenic Escherichia coli infection_Homo sapiens_hsa051303.10780314
5Autoimmune thyroid disease_Homo sapiens_hsa053203.04850420
6Asthma_Homo sapiens_hsa053103.03333408
7Graft-versus-host disease_Homo sapiens_hsa053323.00441228
8Intestinal immune network for IgA production_Homo sapiens_hsa046722.96137477
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.52239778
10Type I diabetes mellitus_Homo sapiens_hsa049402.45018435
11Antigen processing and presentation_Homo sapiens_hsa046122.32245980
12Oxidative phosphorylation_Homo sapiens_hsa001902.24707619
13Caffeine metabolism_Homo sapiens_hsa002322.06420167
14Selenocompound metabolism_Homo sapiens_hsa004502.02614218
15Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.90475601
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.89367650
17Protein export_Homo sapiens_hsa030601.80123575
18Parkinsons disease_Homo sapiens_hsa050121.63587228
19Rheumatoid arthritis_Homo sapiens_hsa053231.55651409
20Tryptophan metabolism_Homo sapiens_hsa003801.50181710
21RNA polymerase_Homo sapiens_hsa030201.49160493
22T cell receptor signaling pathway_Homo sapiens_hsa046601.45341797
23Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.43425289
24Viral myocarditis_Homo sapiens_hsa054161.41837516
25Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.36695484
26Basal transcription factors_Homo sapiens_hsa030221.31901352
27Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.26765953
28Hematopoietic cell lineage_Homo sapiens_hsa046401.25743871
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.17664536
30RNA degradation_Homo sapiens_hsa030181.13405653
31Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.12984510
32Fanconi anemia pathway_Homo sapiens_hsa034601.08007627
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.07412170
34Butanoate metabolism_Homo sapiens_hsa006501.03801780
35Apoptosis_Homo sapiens_hsa042101.02149646
36Phototransduction_Homo sapiens_hsa047441.02013055
37Collecting duct acid secretion_Homo sapiens_hsa049661.00989143
38Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.98923678
39Propanoate metabolism_Homo sapiens_hsa006400.97894389
40Sulfur relay system_Homo sapiens_hsa041220.97692880
41Spliceosome_Homo sapiens_hsa030400.92037648
42Systemic lupus erythematosus_Homo sapiens_hsa053220.91510766
43Chemical carcinogenesis_Homo sapiens_hsa052040.90650825
44Huntingtons disease_Homo sapiens_hsa050160.89652494
45Alzheimers disease_Homo sapiens_hsa050100.89105537
46Measles_Homo sapiens_hsa051620.88385806
47Steroid hormone biosynthesis_Homo sapiens_hsa001400.86242124
48NF-kappa B signaling pathway_Homo sapiens_hsa040640.86130117
49Linoleic acid metabolism_Homo sapiens_hsa005910.83074566
50Nitrogen metabolism_Homo sapiens_hsa009100.82674435
51Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.79843451
52Epstein-Barr virus infection_Homo sapiens_hsa051690.79667061
53Phagosome_Homo sapiens_hsa041450.77890689
54Pyrimidine metabolism_Homo sapiens_hsa002400.75444801
55Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.74027606
56Shigellosis_Homo sapiens_hsa051310.73575014
57alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.73535600
58p53 signaling pathway_Homo sapiens_hsa041150.71921643
59Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.70827773
60Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.70289245
61Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.69451482
62Jak-STAT signaling pathway_Homo sapiens_hsa046300.69183950
63Fatty acid elongation_Homo sapiens_hsa000620.69174480
64Sulfur metabolism_Homo sapiens_hsa009200.68709883
65RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.67767223
66Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.66191572
67Regulation of autophagy_Homo sapiens_hsa041400.61330066
68Herpes simplex infection_Homo sapiens_hsa051680.60806897
69Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.57574671
70SNARE interactions in vesicular transport_Homo sapiens_hsa041300.57003968
71Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.55244691
72Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.54308505
73One carbon pool by folate_Homo sapiens_hsa006700.53823560
74Steroid biosynthesis_Homo sapiens_hsa001000.53780249
75Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.53415548
76Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.52076210
77Legionellosis_Homo sapiens_hsa051340.50167428
78HTLV-I infection_Homo sapiens_hsa051660.47222272
79RNA transport_Homo sapiens_hsa030130.46662215
80Ovarian steroidogenesis_Homo sapiens_hsa049130.45058761
81Peroxisome_Homo sapiens_hsa041460.44838949
82Base excision repair_Homo sapiens_hsa034100.43620204
83NOD-like receptor signaling pathway_Homo sapiens_hsa046210.42592065
84Primary bile acid biosynthesis_Homo sapiens_hsa001200.42248777
85Tuberculosis_Homo sapiens_hsa051520.41430509
86Purine metabolism_Homo sapiens_hsa002300.41091940
87Staphylococcus aureus infection_Homo sapiens_hsa051500.40434707
88Cardiac muscle contraction_Homo sapiens_hsa042600.40145788
89Retinol metabolism_Homo sapiens_hsa008300.39524750
90Leishmaniasis_Homo sapiens_hsa051400.37880307
91Non-homologous end-joining_Homo sapiens_hsa034500.35314105
92Transcriptional misregulation in cancer_Homo sapiens_hsa052020.34688491
932-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.33819135
94Nucleotide excision repair_Homo sapiens_hsa034200.33486713
95Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.32953374
96Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.31994503
97Homologous recombination_Homo sapiens_hsa034400.31853021
98Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.28418030
99TNF signaling pathway_Homo sapiens_hsa046680.23929942
100Hepatitis B_Homo sapiens_hsa051610.23320231

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