ACTG1P15

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.09071677
2Arp2/3 complex-mediated actin nucleation (GO:0034314)5.72933579
3regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.37684643
4actin nucleation (GO:0045010)5.06279975
5cytidine metabolic process (GO:0046087)4.74021991
6cytidine catabolic process (GO:0006216)4.74021991
7cytidine deamination (GO:0009972)4.74021991
8cellular response to interleukin-15 (GO:0071350)4.35362614
9proteasome assembly (GO:0043248)4.22713570
10pyrimidine ribonucleoside catabolic process (GO:0046133)4.18263882
11positive regulation of defense response to virus by host (GO:0002230)3.70208394
12positive regulation of T cell mediated cytotoxicity (GO:0001916)3.70079531
13metallo-sulfur cluster assembly (GO:0031163)3.63109713
14iron-sulfur cluster assembly (GO:0016226)3.63109713
15negative T cell selection (GO:0043383)3.61784318
16protein neddylation (GO:0045116)3.58757297
17negative regulation of T cell apoptotic process (GO:0070233)3.52437022
18protein deneddylation (GO:0000338)3.51721336
19mast cell activation (GO:0045576)3.47124780
20response to interleukin-15 (GO:0070672)3.44625079
21antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.43399036
22positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.43124026
23positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.42560098
24regulation of T cell mediated cytotoxicity (GO:0001914)3.41348817
25protein-cofactor linkage (GO:0018065)3.38927851
26sequestering of actin monomers (GO:0042989)3.37594842
27energy coupled proton transport, down electrochemical gradient (GO:0015985)3.36762709
28ATP synthesis coupled proton transport (GO:0015986)3.36762709
29positive regulation of alpha-beta T cell proliferation (GO:0046641)3.35107627
30negative thymic T cell selection (GO:0045060)3.34162562
31regulation of leukocyte mediated cytotoxicity (GO:0001910)3.28804483
32regulation of T cell receptor signaling pathway (GO:0050856)3.23338365
33regulation of chronic inflammatory response (GO:0002676)3.23279425
34negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.21075477
35regulation of cellular amino acid metabolic process (GO:0006521)3.19327574
36mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.18457818
37positive regulation of prostaglandin secretion (GO:0032308)3.16645846
38positive regulation of calcium-mediated signaling (GO:0050850)3.11451067
39regulation of alpha-beta T cell proliferation (GO:0046640)3.11342320
40positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.08293063
41regulation of regulatory T cell differentiation (GO:0045589)3.03749448
42regulation of defense response to virus by host (GO:0050691)3.02950134
43regulation of immunoglobulin secretion (GO:0051023)3.02503251
44positive regulation of T cell cytokine production (GO:0002726)2.99932469
45regulation of B cell receptor signaling pathway (GO:0050855)2.99774684
46positive regulation of cell killing (GO:0031343)2.99624160
47positive regulation of T cell mediated immunity (GO:0002711)2.97426076
48positive regulation of natural killer cell mediated immunity (GO:0002717)2.96941577
49negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.96546834
50antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.96345212
51cullin deneddylation (GO:0010388)2.95042542
52positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.94958632
53DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.93543392
54mast cell activation involved in immune response (GO:0002279)2.93013567
55mast cell degranulation (GO:0043303)2.93013567
56regulation of cell killing (GO:0031341)2.89759218
57regulation of T cell tolerance induction (GO:0002664)2.89552898
58regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.89480851
59regulation of gamma-delta T cell differentiation (GO:0045586)2.87419596
60signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.85941816
61signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.85941816
62signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.85941816
63positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.85257980
64L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.85220555
65antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.84722140
66negative regulation of cell killing (GO:0031342)2.84091464
67negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.84091464
68positive regulation of tolerance induction (GO:0002645)2.84064517
69positive regulation of interleukin-8 secretion (GO:2000484)2.82689745
70signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.81880249
71intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.81880249
72regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.81792907
73regulation of natural killer cell mediated immunity (GO:0002715)2.81792907
74T cell receptor signaling pathway (GO:0050852)2.81002147
75negative regulation of ligase activity (GO:0051352)2.79967146
76negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.79967146
77regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.77344414
78positive regulation of gamma-delta T cell activation (GO:0046645)2.76130064
79purine deoxyribonucleotide catabolic process (GO:0009155)2.75932655
80interferon-gamma production (GO:0032609)2.75615080
81tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.75277455
82RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.75277455
83signal transduction involved in cell cycle checkpoint (GO:0072395)2.74516995
84positive regulation of humoral immune response (GO:0002922)2.73783715
85signal transduction involved in DNA damage checkpoint (GO:0072422)2.73309519
86signal transduction involved in DNA integrity checkpoint (GO:0072401)2.73309519
87response to interferon-beta (GO:0035456)2.72111051
88regulation of interleukin-8 secretion (GO:2000482)2.69046492
89tumor necrosis factor-mediated signaling pathway (GO:0033209)2.68118507
90nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.67728550
91positive thymic T cell selection (GO:0045059)2.67277685
92positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.67054672
93regulation of activation of Janus kinase activity (GO:0010533)2.66906341
94negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.66665533
95tolerance induction (GO:0002507)2.66543019
96negative regulation of lymphocyte apoptotic process (GO:0070229)2.64945933
97mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.64550089
98positive T cell selection (GO:0043368)2.64129612
99negative regulation of T cell receptor signaling pathway (GO:0050860)2.63930104
100regulation of prostaglandin secretion (GO:0032306)2.63783739

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.86646184
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.60086447
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.47752885
4ELF1_17652178_ChIP-ChIP_JURKAT_Human3.45127310
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.31739034
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.28758714
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.06003007
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.03494177
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.96958413
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.91366467
11IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.86170766
12VDR_23849224_ChIP-Seq_CD4+_Human2.82651615
13FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.82330121
14BP1_19119308_ChIP-ChIP_Hs578T_Human2.59137749
15SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.57339068
16HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.48958730
17E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.43643575
18VDR_22108803_ChIP-Seq_LS180_Human2.29344479
19FLI1_27457419_Chip-Seq_LIVER_Mouse2.28777410
20CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.22922047
21IRF8_21731497_ChIP-ChIP_J774_Mouse2.22683116
22ETS1_20019798_ChIP-Seq_JURKAT_Human2.22225566
23MYB_26560356_Chip-Seq_TH2_Human2.22083836
24STAT4_19710469_ChIP-ChIP_TH1__Mouse2.20952928
25RUNX_20019798_ChIP-Seq_JUKART_Human2.08489498
26FOXP3_21729870_ChIP-Seq_TREG_Human2.03579929
27SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.02588411
28SRF_21415370_ChIP-Seq_HL-1_Mouse2.02188220
29GATA3_26560356_Chip-Seq_TH2_Human2.00758646
30CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.95644120
31ELK1_19687146_ChIP-ChIP_HELA_Human1.84249294
32NOTCH1_21737748_ChIP-Seq_TLL_Human1.80662881
33ZNF274_21170338_ChIP-Seq_K562_Hela1.74909411
34FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.72136941
35PCGF2_27294783_Chip-Seq_ESCs_Mouse1.69409281
36SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.62017310
37IRF1_19129219_ChIP-ChIP_H3396_Human1.61634294
38GATA3_27048872_Chip-Seq_THYMUS_Human1.60641654
39PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.60026319
40CREB1_15753290_ChIP-ChIP_HEK293T_Human1.54486690
41LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.54407728
42EGR1_23403033_ChIP-Seq_LIVER_Mouse1.53528834
43RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.51797794
44MYC_18940864_ChIP-ChIP_HL60_Human1.50706360
45HOXB4_20404135_ChIP-ChIP_EML_Mouse1.50649447
46HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.42415184
47PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.37094947
48CIITA_25753668_ChIP-Seq_RAJI_Human1.37079908
49E2F4_17652178_ChIP-ChIP_JURKAT_Human1.36417037
50YY1_21170310_ChIP-Seq_MESCs_Mouse1.34199517
51GABP_19822575_ChIP-Seq_HepG2_Human1.31951307
52AR_20517297_ChIP-Seq_VCAP_Human1.30895053
53MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.30335379
54MYB_26560356_Chip-Seq_TH1_Human1.23965523
55STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.23551218
56SPI1_23547873_ChIP-Seq_NB4_Human1.23425044
57PADI4_21655091_ChIP-ChIP_MCF-7_Human1.22645709
58IGF1R_20145208_ChIP-Seq_DFB_Human1.21969827
59CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.21264909
60MYC_18358816_ChIP-ChIP_MESCs_Mouse1.20725762
61TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.20668161
62FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.19402765
63TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.19069079
64PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18814957
65EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.16368143
66FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.14627934
67TP53_22573176_ChIP-Seq_HFKS_Human1.14400175
68CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.11895303
69EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.10153302
70PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.10128748
71FOXA1_27270436_Chip-Seq_PROSTATE_Human1.08507986
72FOXA1_25329375_ChIP-Seq_VCAP_Human1.08507986
73TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.08391689
74MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.08247434
75RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.07710255
76PCGF2_27294783_Chip-Seq_NPCs_Mouse1.04866794
77E2F1_18555785_ChIP-Seq_MESCs_Mouse1.04844499
78LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.03998129
79P300_27268052_Chip-Seq_Bcells_Human1.02847186
80NANOG_20526341_ChIP-Seq_ESCs_Human1.02664177
81EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.02387552
82UTX_26944678_Chip-Seq_JUKART_Human1.01763463
83ELK1_22589737_ChIP-Seq_MCF10A_Human1.00057062
84CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.99479252
85PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.99273511
86MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.97369722
87GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.96747142
88BCL6_27268052_Chip-Seq_Bcells_Human0.96709310
89POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.95686918
90RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.94822500
91SUZ12_27294783_Chip-Seq_NPCs_Mouse0.94545045
92NFE2_27457419_Chip-Seq_LIVER_Mouse0.94480083
93GATA3_26560356_Chip-Seq_TH1_Human0.93911206
94MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.93626844
95GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.93087507
96AUTS2_25519132_ChIP-Seq_293T-REX_Human0.92879135
97TAF2_19829295_ChIP-Seq_ESCs_Human0.91184403
98DCP1A_22483619_ChIP-Seq_HELA_Human0.90701786
99FOXH1_21741376_ChIP-Seq_EPCs_Human0.90091094
100MAF_26560356_Chip-Seq_TH1_Human0.88499697

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to5.73241691
2MP0001835_abnormal_antigen_presentation3.75739479
3MP0003724_increased_susceptibility_to2.99741604
4MP0009785_altered_susceptibility_to2.96987417
5MP0003763_abnormal_thymus_physiology2.79484240
6MP0004147_increased_porphyrin_level2.72188537
7MP0005000_abnormal_immune_tolerance2.67499566
8MP0000685_abnormal_immune_system2.64581961
9MP0001800_abnormal_humoral_immune2.60447265
10MP0008875_abnormal_xenobiotic_pharmacok2.48501073
11MP0002148_abnormal_hypersensitivity_rea2.46169948
12MP0003436_decreased_susceptibility_to2.43937271
13MP0002723_abnormal_immune_serum2.39968119
14MP0005387_immune_system_phenotype2.29125738
15MP0001790_abnormal_immune_system2.29125738
16MP0002166_altered_tumor_susceptibility2.19587293
17MP0001819_abnormal_immune_cell2.16989631
18MP0002420_abnormal_adaptive_immunity2.14878280
19MP0002452_abnormal_antigen_presenting2.13658726
20MP0002006_tumorigenesis1.96965728
21MP0005025_abnormal_response_to1.96032197
22MP0009333_abnormal_splenocyte_physiolog1.86009596
23MP0000465_gastrointestinal_hemorrhage1.80277611
24MP0002102_abnormal_ear_morphology1.79432818
25MP0006072_abnormal_retinal_apoptosis1.72598872
26MP0009764_decreased_sensitivity_to1.71740753
27MP0003866_abnormal_defecation1.69647135
28MP0003195_calcinosis1.68974891
29MP0005645_abnormal_hypothalamus_physiol1.66680178
30MP0005377_hearing/vestibular/ear_phenot1.66467760
31MP0003878_abnormal_ear_physiology1.66467760
32MP0002398_abnormal_bone_marrow1.63135127
33MP0008872_abnormal_physiological_respon1.62270459
34MP0000716_abnormal_immune_system1.60984126
35MP0003806_abnormal_nucleotide_metabolis1.58186320
36MP0002933_joint_inflammation1.57538135
37MP0002419_abnormal_innate_immunity1.56135869
38MP0002138_abnormal_hepatobiliary_system1.55255029
39MP0002405_respiratory_system_inflammati1.53735328
40MP0000689_abnormal_spleen_morphology1.51724389
41MP0010155_abnormal_intestine_physiology1.48123810
42MP0005084_abnormal_gallbladder_morpholo1.45558237
43MP0002722_abnormal_immune_system1.44873240
44MP0003786_premature_aging1.44375215
45MP0000703_abnormal_thymus_morphology1.43618062
46MP0001845_abnormal_inflammatory_respons1.38522821
47MP0001533_abnormal_skeleton_physiology1.34193792
48MP0001873_stomach_inflammation1.31432058
49MP0005075_abnormal_melanosome_morpholog1.29848162
50MP0002429_abnormal_blood_cell1.29774866
51MP0003252_abnormal_bile_duct1.27541292
52MP0006036_abnormal_mitochondrial_physio1.25991261
53MP0005360_urolithiasis1.25441033
54MP0000372_irregular_coat_pigmentation1.24733007
55MP0008058_abnormal_DNA_repair1.24230058
56MP0001919_abnormal_reproductive_system1.23503428
57MP0002163_abnormal_gland_morphology1.23202130
58MP0001905_abnormal_dopamine_level1.23169506
59MP0001501_abnormal_sleep_pattern1.21003408
60MP0003693_abnormal_embryo_hatching1.18002016
61MP0002736_abnormal_nociception_after1.13831710
62MP0001853_heart_inflammation1.13006937
63MP0008877_abnormal_DNA_methylation1.11129435
64MP0004947_skin_inflammation1.06685779
65MP0005551_abnormal_eye_electrophysiolog1.04689730
66MP0003646_muscle_fatigue1.03427193
67MP0008469_abnormal_protein_level1.03336966
68MP0005410_abnormal_fertilization1.02954915
69MP0005379_endocrine/exocrine_gland_phen1.01316437
70MP0005253_abnormal_eye_physiology1.00601962
71MP0004145_abnormal_muscle_electrophysio0.98545712
72MP0006082_CNS_inflammation0.98482910
73MP0001968_abnormal_touch/_nociception0.97942926
74MP0001986_abnormal_taste_sensitivity0.97894233
75MP0009763_increased_sensitivity_to0.94538385
76MP0002876_abnormal_thyroid_physiology0.93758225
77MP0001764_abnormal_homeostasis0.93541809
78MP0005389_reproductive_system_phenotype0.91941961
79MP0003011_delayed_dark_adaptation0.84848971
80MP0005464_abnormal_platelet_physiology0.82208566
81MP0010094_abnormal_chromosome_stability0.81068635
82MP0002019_abnormal_tumor_incidence0.80524481
83MP0001765_abnormal_ion_homeostasis0.79848489
84MP0003718_maternal_effect0.78801036
85MP0005636_abnormal_mineral_homeostasis0.78714106
86MP0002277_abnormal_respiratory_mucosa0.73981443
87MP0009765_abnormal_xenobiotic_induced0.71744682
88MP0003638_abnormal_response/metabolism_0.71085530
89MP0003045_fibrosis0.69012020
90MP0005646_abnormal_pituitary_gland0.68681135
91MP0001984_abnormal_olfaction0.68463404
92MP0005083_abnormal_biliary_tract0.68128007
93MP0005085_abnormal_gallbladder_physiolo0.66397904
94MP0003950_abnormal_plasma_membrane0.63818075
95MP0001529_abnormal_vocalization0.63203981
96MP0004957_abnormal_blastocyst_morpholog0.61559081
97MP0004142_abnormal_muscle_tone0.61472484
98MP0003448_altered_tumor_morphology0.60772544
99MP0000858_altered_metastatic_potential0.60279380
100MP0001119_abnormal_female_reproductive0.60062707

Predicted human phenotypes

RankGene SetZ-score
1IgG deficiency (HP:0004315)5.43537578
2Severe combined immunodeficiency (HP:0004430)4.45772496
3T lymphocytopenia (HP:0005403)4.08164497
4Abnormality of T cell number (HP:0011839)3.82509636
5Elevated erythrocyte sedimentation rate (HP:0003565)3.80688799
63-Methylglutaconic aciduria (HP:0003535)3.76696471
7Increased IgM level (HP:0003496)3.57765749
8Abnormality of alanine metabolism (HP:0010916)3.55225304
9Hyperalaninemia (HP:0003348)3.55225304
10Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.55225304
11Combined immunodeficiency (HP:0005387)3.53005030
12Stomatitis (HP:0010280)3.51798639
13Mitochondrial inheritance (HP:0001427)3.24429584
14Hypoproteinemia (HP:0003075)3.19497177
15Abnormality of T cells (HP:0002843)3.15508979
16Abnormality of eosinophils (HP:0001879)3.13208649
17Aplastic anemia (HP:0001915)3.10235633
18Increased CSF lactate (HP:0002490)3.09929965
19Abnormality of the prostate (HP:0008775)3.08061084
20Hepatocellular necrosis (HP:0001404)3.07981093
21Acute necrotizing encephalopathy (HP:0006965)3.03222570
22Abnormal mitochondria in muscle tissue (HP:0008316)2.93734398
23Thyroiditis (HP:0100646)2.93150139
24Hepatic necrosis (HP:0002605)2.89771305
25Increased hepatocellular lipid droplets (HP:0006565)2.81450163
26Chronic mucocutaneous candidiasis (HP:0002728)2.80678273
27Recurrent cutaneous fungal infections (HP:0011370)2.80678273
28Lipid accumulation in hepatocytes (HP:0006561)2.74116089
29Renal Fanconi syndrome (HP:0001994)2.72107312
30Increased intramyocellular lipid droplets (HP:0012240)2.66780163
31Acute encephalopathy (HP:0006846)2.62570138
32Congenital stationary night blindness (HP:0007642)2.54754795
33IgM deficiency (HP:0002850)2.53355872
34Renal cortical cysts (HP:0000803)2.46444294
35Lactic acidosis (HP:0003128)2.46435210
36Increased serum lactate (HP:0002151)2.43432133
37Abolished electroretinogram (ERG) (HP:0000550)2.42045610
38Abnormality of B cell number (HP:0010975)2.38785323
39Cerebral edema (HP:0002181)2.38506026
40Generalized aminoaciduria (HP:0002909)2.37040966
41Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.36955224
42Decreased activity of mitochondrial respiratory chain (HP:0008972)2.36955224
43Decreased electroretinogram (ERG) amplitude (HP:0000654)2.34708153
44Abnormality of T cell physiology (HP:0011840)2.32684701
45Eosinophilia (HP:0001880)2.32373233
46Absent rod-and cone-mediated responses on ERG (HP:0007688)2.32171124
47Prostate neoplasm (HP:0100787)2.31517343
48Recurrent bronchitis (HP:0002837)2.31020826
49Progressive macrocephaly (HP:0004481)2.29648654
50Increased muscle lipid content (HP:0009058)2.29426268
51Attenuation of retinal blood vessels (HP:0007843)2.22737223
52Congenital, generalized hypertrichosis (HP:0004540)2.22705038
53Conical tooth (HP:0000698)2.16613686
54Pancytopenia (HP:0001876)2.16094876
55B lymphocytopenia (HP:0010976)2.15682804
56Myositis (HP:0100614)2.15587567
57Optic disc pallor (HP:0000543)2.11336482
58Exertional dyspnea (HP:0002875)2.08330654
59Hypoplasia of the uterus (HP:0000013)2.06384987
60Recurrent fungal infections (HP:0002841)2.02705417
61Pustule (HP:0200039)2.02484581
62Leukocytosis (HP:0001974)2.01279019
63Encephalitis (HP:0002383)1.99727606
64Cerebral palsy (HP:0100021)1.99536597
65Pulmonary fibrosis (HP:0002206)1.99351419
66Type I transferrin isoform profile (HP:0003642)1.98571687
67Aplasia/hypoplasia of the uterus (HP:0008684)1.97471054
68Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.96817760
69Panhypogammaglobulinemia (HP:0003139)1.96337312
70Hemoptysis (HP:0002105)1.96095617
71Type 2 muscle fiber atrophy (HP:0003554)1.95825229
72Pulmonary infiltrates (HP:0002113)1.95505464
73Abnormal rod and cone electroretinograms (HP:0008323)1.94109374
74Granulocytopenia (HP:0001913)1.93615784
75Chronic diarrhea (HP:0002028)1.92747709
76Pancreatitis (HP:0001733)1.92318837
77Abnormal spermatogenesis (HP:0008669)1.92104690
78Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.90729372
79Brittle hair (HP:0002299)1.89906673
80Short tibia (HP:0005736)1.89210750
81Autoimmune hemolytic anemia (HP:0001890)1.87747630
82Methylmalonic acidemia (HP:0002912)1.87033779
83Decreased central vision (HP:0007663)1.86471343
84Molar tooth sign on MRI (HP:0002419)1.85658016
85Abnormality of midbrain morphology (HP:0002418)1.85658016
86Constricted visual fields (HP:0001133)1.84955737
87Hypoplasia of the thymus (HP:0000778)1.83015617
88Pancreatic cysts (HP:0001737)1.80950413
89Joint swelling (HP:0001386)1.80631003
90Anhidrosis (HP:0000970)1.79692708
91Stomach cancer (HP:0012126)1.78548624
92Vasculitis (HP:0002633)1.76635460
93Abnormal delayed hypersensitivity skin test (HP:0002963)1.75685596
94Abnormality of male internal genitalia (HP:0000022)1.75303161
95Abnormality of the renal cortex (HP:0011035)1.74874450
96Abnormality of serum amino acid levels (HP:0003112)1.73664600
97Lethargy (HP:0001254)1.72918456
98Muscle fiber atrophy (HP:0100295)1.71993975
99Progressive microcephaly (HP:0000253)1.71423726
100Abnormality of the labia minora (HP:0012880)1.71256649

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK14.68706111
2TXK4.35956853
3TESK24.13444863
4ZAK3.98998009
5MAP4K23.56551684
6BCKDK3.14022750
7KDR3.07235543
8VRK22.69530285
9TAOK32.63428882
10MAP3K122.54820956
11VRK12.16818023
12MAP4K11.98590719
13TESK11.93994712
14LIMK11.87080620
15GRK61.83737504
16NUAK11.81725110
17BUB11.68616150
18FES1.59160413
19NEK11.55493343
20MAP3K141.45245240
21BMPR21.44586488
22ADRBK21.38787833
23IKBKB1.37480859
24TIE11.34061714
25MAP2K21.23318904
26GRK11.21634909
27MST41.20245572
28TBK11.15850237
29MYLK1.15303410
30DAPK11.14602260
31IKBKE1.14108528
32MUSK1.12710824
33SYK1.02545374
34ITK1.02174855
35RPS6KA50.98310935
36MAPKAPK30.96782739
37SCYL20.94607812
38TRIM280.90286823
39CSNK1G30.90206628
40ZAP700.89077025
41LCK0.88997769
42PINK10.87827796
43CSF1R0.87240951
44PRKCQ0.85327523
45SRPK10.83404031
46CCNB10.82444084
47MATK0.78772744
48TEC0.75932744
49EIF2AK20.75285690
50BTK0.74651377
51WNK40.73392158
52CSNK1A1L0.71587149
53RPS6KA40.70499933
54PIM10.69755328
55EIF2AK30.69643153
56INSRR0.68364599
57KIT0.68351828
58PDK20.67544556
59CSNK1G10.66212730
60LYN0.65257723
61NME10.61357721
62CDK190.59231942
63OXSR10.57168619
64WNK30.56801546
65CSNK1G20.54662952
66GRK50.53208217
67ERBB30.52552163
68AURKA0.50307241
69CSK0.49757771
70GRK70.49259914
71MAPKAPK50.48905583
72JAK10.48267315
73IGF1R0.46966209
74MAP3K110.45546165
75PHKG20.45121440
76PHKG10.45121440
77STK160.44614070
78TSSK60.42291951
79JAK30.41899989
80RIPK40.41402189
81BLK0.41227422
82DAPK30.39486992
83TNK20.39471169
84PKN10.35698522
85ILK0.35370266
86PAK10.33320823
87MAP3K50.30715297
88PLK30.30542050
89BCR0.29383732
90ADRBK10.28894267
91ATR0.26979957
92CDK80.26290337
93AURKB0.26238979
94HCK0.26024869
95PLK40.24922681
96ROCK10.24597424
97DYRK20.24407177
98CHUK0.24289660
99ABL10.23007258
100MAPK130.22737219

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.07569613
2Primary immunodeficiency_Homo sapiens_hsa053403.74177334
3Graft-versus-host disease_Homo sapiens_hsa053323.00250124
4Allograft rejection_Homo sapiens_hsa053302.83767148
5Autoimmune thyroid disease_Homo sapiens_hsa053202.76361335
6Asthma_Homo sapiens_hsa053102.72711436
7Oxidative phosphorylation_Homo sapiens_hsa001902.69138177
8Intestinal immune network for IgA production_Homo sapiens_hsa046722.63107364
9Caffeine metabolism_Homo sapiens_hsa002322.47489316
10Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.43335028
11Parkinsons disease_Homo sapiens_hsa050122.28970514
12Antigen processing and presentation_Homo sapiens_hsa046122.25884575
13Type I diabetes mellitus_Homo sapiens_hsa049402.17165063
14Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.02787228
15Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.97216096
16RNA polymerase_Homo sapiens_hsa030201.95218612
17Protein export_Homo sapiens_hsa030601.82454091
18Systemic lupus erythematosus_Homo sapiens_hsa053221.78967711
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.67977707
20Rheumatoid arthritis_Homo sapiens_hsa053231.62191283
21Viral myocarditis_Homo sapiens_hsa054161.48159060
22Hematopoietic cell lineage_Homo sapiens_hsa046401.44538980
23NF-kappa B signaling pathway_Homo sapiens_hsa040641.37243979
24Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.36642593
25Alzheimers disease_Homo sapiens_hsa050101.35014693
26Huntingtons disease_Homo sapiens_hsa050161.33565132
27Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.29809055
28Phototransduction_Homo sapiens_hsa047441.29249925
29T cell receptor signaling pathway_Homo sapiens_hsa046601.23232852
30RNA degradation_Homo sapiens_hsa030181.22484121
31Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.21618362
32Tryptophan metabolism_Homo sapiens_hsa003801.19027840
33Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.18950776
34Nitrogen metabolism_Homo sapiens_hsa009101.18918991
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.12299812
36Homologous recombination_Homo sapiens_hsa034401.11185763
37Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.10117541
38Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.06974452
39Sulfur metabolism_Homo sapiens_hsa009201.05505118
40Shigellosis_Homo sapiens_hsa051311.01858794
41Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.97816295
42Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.97061831
43Spliceosome_Homo sapiens_hsa030400.96214421
44NOD-like receptor signaling pathway_Homo sapiens_hsa046210.90781680
45Propanoate metabolism_Homo sapiens_hsa006400.89859199
46Purine metabolism_Homo sapiens_hsa002300.84184332
47Pyrimidine metabolism_Homo sapiens_hsa002400.83727052
48Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.83263915
49DNA replication_Homo sapiens_hsa030300.82489890
50Cardiac muscle contraction_Homo sapiens_hsa042600.81741096
51Fanconi anemia pathway_Homo sapiens_hsa034600.76584023
52Nucleotide excision repair_Homo sapiens_hsa034200.76433071
53Fatty acid elongation_Homo sapiens_hsa000620.75714199
54Cysteine and methionine metabolism_Homo sapiens_hsa002700.75705997
55Mismatch repair_Homo sapiens_hsa034300.74737283
56Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.74192848
57Peroxisome_Homo sapiens_hsa041460.73989239
58Ribosome_Homo sapiens_hsa030100.73948010
59One carbon pool by folate_Homo sapiens_hsa006700.70491397
60Basal transcription factors_Homo sapiens_hsa030220.70478069
61Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.69899041
62RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.69625848
63Collecting duct acid secretion_Homo sapiens_hsa049660.67726117
64Herpes simplex infection_Homo sapiens_hsa051680.67594356
65Leishmaniasis_Homo sapiens_hsa051400.67474366
66Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.67467372
67Measles_Homo sapiens_hsa051620.64182676
68Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.64168831
69Base excision repair_Homo sapiens_hsa034100.61916390
70Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.60489339
71Epstein-Barr virus infection_Homo sapiens_hsa051690.60246335
72alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.60059772
73Linoleic acid metabolism_Homo sapiens_hsa005910.59657278
74Staphylococcus aureus infection_Homo sapiens_hsa051500.59522621
75Chemical carcinogenesis_Homo sapiens_hsa052040.59381315
76Alcoholism_Homo sapiens_hsa050340.58719535
77SNARE interactions in vesicular transport_Homo sapiens_hsa041300.53744648
78RNA transport_Homo sapiens_hsa030130.53717244
79Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.52848812
80Legionellosis_Homo sapiens_hsa051340.50923537
81Regulation of autophagy_Homo sapiens_hsa041400.49867331
82Drug metabolism - other enzymes_Homo sapiens_hsa009830.48135403
83Primary bile acid biosynthesis_Homo sapiens_hsa001200.47694885
84Sulfur relay system_Homo sapiens_hsa041220.46291726
85Phenylalanine metabolism_Homo sapiens_hsa003600.44313638
86Metabolic pathways_Homo sapiens_hsa011000.40643233
87Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.37075575
88Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.36681315
89Butanoate metabolism_Homo sapiens_hsa006500.35978882
90Malaria_Homo sapiens_hsa051440.35383807
91Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.32557582
92Olfactory transduction_Homo sapiens_hsa047400.32080458
93Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.30074540
94Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.28350246
95Non-homologous end-joining_Homo sapiens_hsa034500.27356362
96Retinol metabolism_Homo sapiens_hsa008300.26764693
97Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.25782839
98Tyrosine metabolism_Homo sapiens_hsa003500.25780110
99Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.25175072
100Arachidonic acid metabolism_Homo sapiens_hsa005900.23112702

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