ACTG1P17

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein polyglutamylation (GO:0018095)5.17215106
2sperm motility (GO:0030317)5.09754213
3DNA deamination (GO:0045006)5.02391697
4L-fucose catabolic process (GO:0042355)4.64334995
5fucose catabolic process (GO:0019317)4.64334995
6L-fucose metabolic process (GO:0042354)4.64334995
7response to pheromone (GO:0019236)4.56903872
8behavioral response to nicotine (GO:0035095)4.43710177
9single strand break repair (GO:0000012)4.43459834
10regulation of cilium movement (GO:0003352)4.26909807
11establishment of protein localization to Golgi (GO:0072600)4.25701638
12axoneme assembly (GO:0035082)4.10616085
13acrosome reaction (GO:0007340)4.09791920
14protein targeting to Golgi (GO:0000042)4.08445354
15epithelial cilium movement (GO:0003351)4.06380296
16negative regulation of telomere maintenance (GO:0032205)3.94655825
17regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.74821420
18multicellular organism reproduction (GO:0032504)3.70439900
19retrograde transport, vesicle recycling within Golgi (GO:0000301)3.62064124
20fusion of sperm to egg plasma membrane (GO:0007342)3.54416342
21heart field specification (GO:0003128)3.51129496
22secondary heart field specification (GO:0003139)3.51129496
23seminiferous tubule development (GO:0072520)3.50582119
24cilium movement (GO:0003341)3.50499891
25cytidine deamination (GO:0009972)3.49298409
26cytidine metabolic process (GO:0046087)3.49298409
27cytidine catabolic process (GO:0006216)3.49298409
28arginine catabolic process (GO:0006527)3.48222373
29detection of light stimulus involved in sensory perception (GO:0050962)3.44890761
30detection of light stimulus involved in visual perception (GO:0050908)3.44890761
31specification of organ identity (GO:0010092)3.43176582
32protein localization to Golgi apparatus (GO:0034067)3.40954888
33cilium or flagellum-dependent cell motility (GO:0001539)3.38868550
34spermatid development (GO:0007286)3.36381240
35piRNA metabolic process (GO:0034587)3.36226652
36rRNA methylation (GO:0031167)3.28268241
37axonemal dynein complex assembly (GO:0070286)3.25722307
38cellular ketone body metabolic process (GO:0046950)3.23133516
39epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.22783610
40regulation of mesoderm development (GO:2000380)3.22279203
41pyrimidine ribonucleoside catabolic process (GO:0046133)3.21770847
42centriole replication (GO:0007099)3.19125425
43regulation of microtubule-based movement (GO:0060632)3.11051182
44sperm-egg recognition (GO:0035036)3.09957042
45DNA methylation involved in gamete generation (GO:0043046)3.08705779
46regulation of action potential (GO:0098900)3.08418281
47regulation of telomere maintenance (GO:0032204)3.08145596
48indole-containing compound catabolic process (GO:0042436)3.02085935
49indolalkylamine catabolic process (GO:0046218)3.02085935
50tryptophan catabolic process (GO:0006569)3.02085935
51rRNA modification (GO:0000154)3.01697571
52spermatid nucleus differentiation (GO:0007289)3.01387268
53microtubule polymerization or depolymerization (GO:0031109)3.00752862
54regulation of neurotransmitter uptake (GO:0051580)3.00697303
55platelet dense granule organization (GO:0060155)3.00150575
56somite rostral/caudal axis specification (GO:0032525)2.99661875
57detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.98852169
58cellular anion homeostasis (GO:0030002)2.95225732
59microtubule severing (GO:0051013)2.94537591
60water-soluble vitamin biosynthetic process (GO:0042364)2.90847173
61indolalkylamine metabolic process (GO:0006586)2.90831129
62synaptic transmission, cholinergic (GO:0007271)2.88785371
63male meiosis (GO:0007140)2.85757184
64ketone body metabolic process (GO:1902224)2.85448951
65plasma membrane fusion (GO:0045026)2.83222555
66microtubule depolymerization (GO:0007019)2.80810876
67mitochondrial respiratory chain complex I assembly (GO:0032981)2.80293876
68NADH dehydrogenase complex assembly (GO:0010257)2.80293876
69mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.80293876
70cilium morphogenesis (GO:0060271)2.79207434
71regulation of telomere maintenance via telomerase (GO:0032210)2.78699093
72detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.78280084
73RNA destabilization (GO:0050779)2.78216938
74phosphatidylethanolamine biosynthetic process (GO:0006646)2.77467213
75male meiosis I (GO:0007141)2.77358796
76pyrimidine nucleobase catabolic process (GO:0006208)2.75786210
77negative regulation of multicellular organism growth (GO:0040015)2.75433100
78protein complex biogenesis (GO:0070271)2.73390559
79phosphatidylethanolamine metabolic process (GO:0046337)2.72663692
80positive regulation of defense response to virus by host (GO:0002230)2.72314991
81cardiac ventricle formation (GO:0003211)2.71151234
82exogenous drug catabolic process (GO:0042738)2.70990797
83preassembly of GPI anchor in ER membrane (GO:0016254)2.69402679
84photoreceptor cell maintenance (GO:0045494)2.66597144
85regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.65374054
86regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.65374054
87cell-cell recognition (GO:0009988)2.65131002
88kynurenine metabolic process (GO:0070189)2.64558857
89positive regulation of cell fate commitment (GO:0010455)2.59825549
90male gamete generation (GO:0048232)2.57305989
91cilium organization (GO:0044782)2.57141143
92spermatogenesis (GO:0007283)2.56402270
93reproduction (GO:0000003)2.55855162
94postsynaptic membrane organization (GO:0001941)2.52712437
95photoreceptor cell development (GO:0042461)2.52256521
96tryptophan metabolic process (GO:0006568)2.52114448
97calcium ion-dependent exocytosis (GO:0017156)2.51089543
98positive regulation of mitochondrial fission (GO:0090141)2.50979400
99tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.50879273
100RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.50879273

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.95357121
2VDR_22108803_ChIP-Seq_LS180_Human3.25530074
3EZH2_22144423_ChIP-Seq_EOC_Human2.62614226
4CTBP2_25329375_ChIP-Seq_LNCAP_Human2.40220748
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.27629215
6IGF1R_20145208_ChIP-Seq_DFB_Human2.23813170
7FUS_26573619_Chip-Seq_HEK293_Human2.20874672
8MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.16652664
9GBX2_23144817_ChIP-Seq_PC3_Human2.14508887
10CTBP1_25329375_ChIP-Seq_LNCAP_Human2.10946897
11EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human2.08790294
12SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.02132927
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.96623756
14GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.96311548
15ZFP57_27257070_Chip-Seq_ESCs_Mouse1.95816803
16TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.90705143
17POU3F2_20337985_ChIP-ChIP_501MEL_Human1.83225248
18P300_19829295_ChIP-Seq_ESCs_Human1.81611182
19SALL1_21062744_ChIP-ChIP_HESCs_Human1.79838515
20ER_23166858_ChIP-Seq_MCF-7_Human1.79798302
21HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.79774892
22UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.77616751
23E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.76856181
24IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.72612284
25CBP_20019798_ChIP-Seq_JUKART_Human1.72612284
26FLI1_27457419_Chip-Seq_LIVER_Mouse1.72210302
27NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.63995086
28TAF15_26573619_Chip-Seq_HEK293_Human1.63588366
29ERA_21632823_ChIP-Seq_H3396_Human1.54742440
30TP53_22573176_ChIP-Seq_HFKS_Human1.51712956
31GATA3_21878914_ChIP-Seq_MCF-7_Human1.48801087
32EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.48238445
33MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.46831502
34ETV2_25802403_ChIP-Seq_MESCs_Mouse1.46724105
35IRF1_19129219_ChIP-ChIP_H3396_Human1.46223604
36TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.46162840
37AR_25329375_ChIP-Seq_VCAP_Human1.43804533
38TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43721441
39POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.43721441
40NCOR_22424771_ChIP-Seq_293T_Human1.41364313
41STAT3_23295773_ChIP-Seq_U87_Human1.41140697
42MYC_19829295_ChIP-Seq_ESCs_Human1.41105336
43SOX2_19829295_ChIP-Seq_ESCs_Human1.39855419
44NANOG_19829295_ChIP-Seq_ESCs_Human1.39855419
45GABP_17652178_ChIP-ChIP_JURKAT_Human1.37279275
46NANOG_20526341_ChIP-Seq_ESCs_Human1.36907003
47SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36549029
48KLF5_20875108_ChIP-Seq_MESCs_Mouse1.36011558
49PCGF2_27294783_Chip-Seq_ESCs_Mouse1.35673301
50FOXA1_21572438_ChIP-Seq_LNCaP_Human1.35533306
51GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.35278042
52AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.34966011
53REST_21632747_ChIP-Seq_MESCs_Mouse1.34908167
54TAF2_19829295_ChIP-Seq_ESCs_Human1.34249210
55EWS_26573619_Chip-Seq_HEK293_Human1.33149929
56FOXA1_25329375_ChIP-Seq_VCAP_Human1.32194129
57FOXA1_27270436_Chip-Seq_PROSTATE_Human1.32194129
58HOXB7_26014856_ChIP-Seq_BT474_Human1.30551341
59BCAT_22108803_ChIP-Seq_LS180_Human1.29495732
60OCT4_20526341_ChIP-Seq_ESCs_Human1.27039487
61SMAD4_21741376_ChIP-Seq_EPCs_Human1.26933280
62SMAD4_21799915_ChIP-Seq_A2780_Human1.26543289
63SMAD3_21741376_ChIP-Seq_EPCs_Human1.26074448
64TCF4_23295773_ChIP-Seq_U87_Human1.25866856
65PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.25620384
66RUNX2_22187159_ChIP-Seq_PCA_Human1.22568483
67TCF4_22108803_ChIP-Seq_LS180_Human1.22518110
68NR3C1_21868756_ChIP-Seq_MCF10A_Human1.21820921
69TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.20063143
70BMI1_23680149_ChIP-Seq_NPCS_Mouse1.19300016
71MYC_18940864_ChIP-ChIP_HL60_Human1.19188804
72FOXH1_21741376_ChIP-Seq_EPCs_Human1.17687909
73PRDM14_20953172_ChIP-Seq_ESCs_Human1.16070740
74NOTCH1_21737748_ChIP-Seq_TLL_Human1.15867069
75P53_21459846_ChIP-Seq_SAOS-2_Human1.15238996
76TOP2B_26459242_ChIP-Seq_MCF-7_Human1.14680919
77CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.14043322
78PIAS1_25552417_ChIP-Seq_VCAP_Human1.14034743
79EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.12632022
80AR_20517297_ChIP-Seq_VCAP_Human1.10668021
81RNF2_27304074_Chip-Seq_NSC_Mouse1.10457912
82CBX2_27304074_Chip-Seq_ESCs_Mouse1.09728439
83AUTS2_25519132_ChIP-Seq_293T-REX_Human1.09334849
84PCGF2_27294783_Chip-Seq_NPCs_Mouse1.09189525
85CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.08210375
86MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.07494791
87EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.07079912
88SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.07012316
89PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.06967207
90ETV1_20927104_ChIP-Seq_GIST48_Human1.06906608
91REST_18959480_ChIP-ChIP_MESCs_Mouse1.05918549
92RAC3_21632823_ChIP-Seq_H3396_Human1.05783959
93EST1_17652178_ChIP-ChIP_JURKAT_Human1.05046560
94PHF8_20622853_ChIP-Seq_HELA_Human1.02120012
95CDX2_22108803_ChIP-Seq_LS180_Human1.01900164
96FOXH1_21741376_ChIP-Seq_ESCs_Human1.01363707
97ERG_20517297_ChIP-Seq_VCAP_Human1.01326476
98RBPJ_21746931_ChIP-Seq_IB4_Human1.01188177
99EGR1_23403033_ChIP-Seq_LIVER_Mouse0.98751344
100KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.98209136

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization3.53308370
2MP0002234_abnormal_pharynx_morphology3.10634566
3MP0003646_muscle_fatigue2.80092819
4MP0006292_abnormal_olfactory_placode2.62212311
5MP0008877_abnormal_DNA_methylation2.57959521
6MP0002102_abnormal_ear_morphology2.52530968
7MP0005551_abnormal_eye_electrophysiolog2.48259012
8MP0003878_abnormal_ear_physiology2.25205758
9MP0005377_hearing/vestibular/ear_phenot2.25205758
10MP0001986_abnormal_taste_sensitivity2.23427758
11MP0004147_increased_porphyrin_level2.05324253
12MP0008872_abnormal_physiological_respon2.04968359
13MP0003011_delayed_dark_adaptation1.98314609
14MP0001968_abnormal_touch/_nociception1.95066476
15MP0002837_dystrophic_cardiac_calcinosis1.94383056
16MP0001873_stomach_inflammation1.93767563
17MP0003787_abnormal_imprinting1.78515204
18MP0008875_abnormal_xenobiotic_pharmacok1.72254214
19MP0003698_abnormal_male_reproductive1.71576308
20MP0005253_abnormal_eye_physiology1.70749768
21MP0006276_abnormal_autonomic_nervous1.69309356
22MP0001486_abnormal_startle_reflex1.68496870
23MP0003880_abnormal_central_pattern1.68269494
24MP0001485_abnormal_pinna_reflex1.67449376
25MP0006072_abnormal_retinal_apoptosis1.65034302
26MP0005645_abnormal_hypothalamus_physiol1.64812178
27MP0000569_abnormal_digit_pigmentation1.64801795
28MP0003195_calcinosis1.64743030
29MP0009745_abnormal_behavioral_response1.63383883
30MP0005379_endocrine/exocrine_gland_phen1.61784214
31MP0001348_abnormal_lacrimal_gland1.58438173
32MP0002876_abnormal_thyroid_physiology1.55290689
33MP0002736_abnormal_nociception_after1.50558473
34MP0001929_abnormal_gametogenesis1.46898835
35MP0002735_abnormal_chemical_nociception1.44575550
36MP0005084_abnormal_gallbladder_morpholo1.41694189
37MP0009046_muscle_twitch1.37222752
38MP0008775_abnormal_heart_ventricle1.36759394
39MP0005646_abnormal_pituitary_gland1.36202466
40MP0004885_abnormal_endolymph1.35848685
41MP0001984_abnormal_olfaction1.35033071
42MP0002272_abnormal_nervous_system1.32722406
43MP0004742_abnormal_vestibular_system1.31199402
44MP0002638_abnormal_pupillary_reflex1.29139020
45MP0004043_abnormal_pH_regulation1.28533445
46MP0008789_abnormal_olfactory_epithelium1.27859545
47MP0005174_abnormal_tail_pigmentation1.27347384
48MP0002163_abnormal_gland_morphology1.26331523
49MP0000631_abnormal_neuroendocrine_gland1.25311674
50MP0002733_abnormal_thermal_nociception1.22539433
51MP0005167_abnormal_blood-brain_barrier1.22268684
52MP0001501_abnormal_sleep_pattern1.21780814
53MP0005670_abnormal_white_adipose1.19521042
54MP0003718_maternal_effect1.17747549
55MP0003950_abnormal_plasma_membrane1.16116017
56MP0000372_irregular_coat_pigmentation1.15531898
57MP0001905_abnormal_dopamine_level1.13024437
58MP0004133_heterotaxia1.11898868
59MP0002653_abnormal_ependyma_morphology1.08326761
60MP0004130_abnormal_muscle_cell1.06541819
61MP0004142_abnormal_muscle_tone1.06445096
62MP0002210_abnormal_sex_determination1.05934480
63MP0008058_abnormal_DNA_repair1.04067802
64MP0001529_abnormal_vocalization1.04017353
65MP0002938_white_spotting1.03974849
66MP0002557_abnormal_social/conspecific_i1.03334646
67MP0003137_abnormal_impulse_conducting1.02842234
68MP0001970_abnormal_pain_threshold1.02540052
69MP0003136_yellow_coat_color1.01651125
70MP0001963_abnormal_hearing_physiology1.01072999
71MP0002822_catalepsy1.00622641
72MP0002572_abnormal_emotion/affect_behav0.99551695
73MP0005389_reproductive_system_phenotype0.99199295
74MP0000427_abnormal_hair_cycle0.98203833
75MP0005075_abnormal_melanosome_morpholog0.95415527
76MP0002229_neurodegeneration0.95347128
77MP0000230_abnormal_systemic_arterial0.94953042
78MP0005332_abnormal_amino_acid0.94871913
79MP0002160_abnormal_reproductive_system0.94297197
80MP0002138_abnormal_hepatobiliary_system0.91344503
81MP0005423_abnormal_somatic_nervous0.90985795
82MP0002928_abnormal_bile_duct0.90578925
83MP0005394_taste/olfaction_phenotype0.89437452
84MP0005499_abnormal_olfactory_system0.89437452
85MP0005195_abnormal_posterior_eye0.89099129
86MP0008995_early_reproductive_senescence0.88363194
87MP0000653_abnormal_sex_gland0.88235207
88MP0000026_abnormal_inner_ear0.87490357
89MP0002752_abnormal_somatic_nervous0.86887110
90MP0002693_abnormal_pancreas_physiology0.86804913
91MP0002067_abnormal_sensory_capabilities0.86695552
92MP0004145_abnormal_muscle_electrophysio0.85687371
93MP0001919_abnormal_reproductive_system0.85025061
94MP0003635_abnormal_synaptic_transmissio0.84851587
95MP0002095_abnormal_skin_pigmentation0.84644407
96MP0002751_abnormal_autonomic_nervous0.84018908
97MP0001764_abnormal_homeostasis0.83046151
98MP0003252_abnormal_bile_duct0.82587287
99MP0002184_abnormal_innervation0.82323923
100MP0005360_urolithiasis0.82087824

Predicted human phenotypes

RankGene SetZ-score
1Nephronophthisis (HP:0000090)4.14813705
2Pancreatic cysts (HP:0001737)3.97326541
3Chronic hepatic failure (HP:0100626)3.88292006
4Abnormality of midbrain morphology (HP:0002418)3.85037166
5Molar tooth sign on MRI (HP:0002419)3.85037166
6Birth length less than 3rd percentile (HP:0003561)3.74697762
7Congenital stationary night blindness (HP:0007642)3.72371988
8Pancreatic fibrosis (HP:0100732)3.71888651
9True hermaphroditism (HP:0010459)3.66095890
10Autoimmune thrombocytopenia (HP:0001973)3.45786419
11Abnormality of the renal medulla (HP:0100957)3.45705934
12Severe visual impairment (HP:0001141)3.41438346
13Attenuation of retinal blood vessels (HP:0007843)3.29477650
14Pendular nystagmus (HP:0012043)3.15685486
15Increased IgM level (HP:0003496)3.05308748
16Abnormality of the renal cortex (HP:0011035)3.04840795
17Abnormal rod and cone electroretinograms (HP:0008323)3.04447632
18Abnormal drinking behavior (HP:0030082)2.96176881
19Polydipsia (HP:0001959)2.96176881
20Progressive cerebellar ataxia (HP:0002073)2.95387273
21Type II lissencephaly (HP:0007260)2.95071811
22Medial flaring of the eyebrow (HP:0010747)2.94607820
23Genetic anticipation (HP:0003743)2.91535756
24Absent/shortened dynein arms (HP:0200106)2.73955707
25Dynein arm defect of respiratory motile cilia (HP:0012255)2.73955707
26Abnormal delayed hypersensitivity skin test (HP:0002963)2.63843878
27Tubular atrophy (HP:0000092)2.62770884
28Tubulointerstitial nephritis (HP:0001970)2.49448658
29Increased corneal curvature (HP:0100692)2.44104973
30Keratoconus (HP:0000563)2.44104973
31Cystic liver disease (HP:0006706)2.40553370
32Gaze-evoked nystagmus (HP:0000640)2.40067854
33Decreased central vision (HP:0007663)2.39248068
34Polyuria (HP:0000103)2.38396857
35Autoimmune hemolytic anemia (HP:0001890)2.37691400
36Abolished electroretinogram (ERG) (HP:0000550)2.32837276
37Abnormal respiratory motile cilium morphology (HP:0005938)2.30219765
38Abnormal respiratory epithelium morphology (HP:0012253)2.30219765
39Bile duct proliferation (HP:0001408)2.29984695
40Abnormal biliary tract physiology (HP:0012439)2.29984695
41Absent rod-and cone-mediated responses on ERG (HP:0007688)2.29225930
42Lissencephaly (HP:0001339)2.28729260
43Enlarged epiphyses (HP:0010580)2.24559775
44Bony spicule pigmentary retinopathy (HP:0007737)2.24184204
45Anterior segment dysgenesis (HP:0007700)2.22385184
46Hyperventilation (HP:0002883)2.18822251
47Abnormality of macular pigmentation (HP:0008002)2.18653037
48Sclerocornea (HP:0000647)2.18337776
49Cerebellar dysplasia (HP:0007033)2.17471238
50Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.15590700
51Abnormal respiratory motile cilium physiology (HP:0012261)2.13021579
52Renal cortical cysts (HP:0000803)2.11370796
53Abnormal ciliary motility (HP:0012262)2.10866804
54Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.10725573
55Decreased activity of mitochondrial respiratory chain (HP:0008972)2.10725573
56Inability to walk (HP:0002540)2.10705384
57Decreased electroretinogram (ERG) amplitude (HP:0000654)2.09298332
58Anencephaly (HP:0002323)2.07423129
59Abnormal urine output (HP:0012590)2.04113126
60Gait imbalance (HP:0002141)2.03424101
61Hypochromic anemia (HP:0001931)2.02294977
62Nephrogenic diabetes insipidus (HP:0009806)2.01959260
63Constricted visual fields (HP:0001133)2.01422486
64Congenital primary aphakia (HP:0007707)1.99658942
65Congenital hepatic fibrosis (HP:0002612)1.99584009
66Optic nerve hypoplasia (HP:0000609)1.98504522
673-Methylglutaconic aciduria (HP:0003535)1.93423042
68Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.92542151
69Depressed nasal tip (HP:0000437)1.91933034
70Type 2 muscle fiber atrophy (HP:0003554)1.89432114
71Abnormal albumin level (HP:0012116)1.89372916
72Hypoalbuminemia (HP:0003073)1.89372916
73Insulin-resistant diabetes mellitus (HP:0000831)1.89135363
74Mitochondrial inheritance (HP:0001427)1.88654116
75Epileptic encephalopathy (HP:0200134)1.87588547
76Postaxial foot polydactyly (HP:0001830)1.87361922
77Broad-based gait (HP:0002136)1.85270668
78Aplasia/Hypoplasia of the tongue (HP:0010295)1.83800364
79Abnormality of T cell physiology (HP:0011840)1.81354754
80Male pseudohermaphroditism (HP:0000037)1.79434195
81Hepatocellular necrosis (HP:0001404)1.78657771
82Abnormality of renal excretion (HP:0011036)1.77795826
83Retinal dysplasia (HP:0007973)1.77347077
84Hypomagnesemia (HP:0002917)1.76850844
85Stage 5 chronic kidney disease (HP:0003774)1.76359451
86Increased CSF lactate (HP:0002490)1.74387248
87Hyperglycinemia (HP:0002154)1.73574174
88Oculomotor apraxia (HP:0000657)1.73477616
89Progressive microcephaly (HP:0000253)1.71139055
90Acute necrotizing encephalopathy (HP:0006965)1.69816141
91Abnormality of eosinophils (HP:0001879)1.69814763
92Retinitis pigmentosa (HP:0000510)1.68929607
93Decreased circulating renin level (HP:0003351)1.68243582
94Hypoplasia of the fovea (HP:0007750)1.67717074
95Aplasia/Hypoplasia of the fovea (HP:0008060)1.67717074
96Hepatic necrosis (HP:0002605)1.66631978
97Large for gestational age (HP:0001520)1.66270960
98Methylmalonic acidemia (HP:0002912)1.66147063
99Aplasia/Hypoplasia of the patella (HP:0006498)1.65681315
100Glycosuria (HP:0003076)1.65369148

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK14.42770781
2FRK4.34002129
3MAP4K23.42255053
4CDK193.40550000
5PIK3CA2.98038433
6OXSR12.86486493
7PLK42.71047096
8INSRR2.44608975
9ADRBK22.41807389
10TXK2.31243171
11TAOK32.21430712
12PINK12.19989351
13BMPR1B2.08883989
14ZAK2.07675474
15WNK41.95055884
16GRK11.87485522
17WNK31.76481708
18NUAK11.74284622
19ACVR1B1.64851035
20PLK21.62297332
21MAPK131.50863778
22DAPK21.32521490
23TRIM281.27290334
24CASK1.26092636
25CAMKK21.22353942
26MAP3K41.21780067
27PRKCG1.21603726
28STK391.15858698
29MUSK1.15036356
30CSNK1G31.14145932
31MAP2K71.04521124
32STK160.99359662
33MKNK20.98260625
34CSNK1G20.97972823
35CSNK1G10.97569977
36TEC0.96704157
37CSNK1A1L0.96071739
38MAP2K60.95454341
39BCR0.95225418
40KIT0.94933723
41GRK70.93582575
42CAMK1G0.93462738
43DYRK20.92060774
44BRD40.91489799
45PAK30.86234105
46ADRBK10.85990479
47CAMK1D0.82032495
48MARK10.81334919
49STK110.80926391
50BCKDK0.76917972
51ITK0.75124303
52TIE10.75076860
53MAP3K70.73031920
54MAPK150.72486603
55FGFR20.72428258
56TNK20.72207837
57PTK2B0.69888494
58MAPKAPK30.69464938
59PIK3CG0.68198644
60MST40.68044839
61CAMK10.66698135
62SIK20.66147408
63NTRK30.64236214
64PRKCE0.62018051
65PNCK0.61010616
66EPHA40.60736975
67STK38L0.59840885
68NME10.59192625
69NTRK20.58514075
70EIF2AK30.56340118
71VRK20.55967463
72MINK10.53868028
73VRK10.53142740
74PHKG20.52686555
75PHKG10.52686555
76MAPKAPK50.52507057
77IKBKB0.48829339
78CSNK1A10.48634267
79PRKAA10.47439956
80PKN10.45600691
81CAMK2A0.45521509
82TNIK0.44802347
83PRKCI0.44667468
84CSNK1D0.43058441
85PRKACA0.41665799
86RPS6KA50.39195850
87PRKCQ0.38198626
88STK30.37183243
89IGF1R0.35625208
90MKNK10.35567473
91PRKG10.35464463
92PDK10.32914588
93SYK0.31338821
94GRK50.31282116
95CCNB10.29938274
96PRKAA20.29287398
97MARK30.29205237
98PRKCA0.28729318
99BTK0.28295004
100LCK0.27592682

Predicted pathways (KEGG)

RankGene SetZ-score
1Caffeine metabolism_Homo sapiens_hsa002322.94704345
2Phototransduction_Homo sapiens_hsa047442.83067556
3Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.79950788
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.78852163
5Linoleic acid metabolism_Homo sapiens_hsa005912.77474602
6Olfactory transduction_Homo sapiens_hsa047402.33697264
7Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.25263795
8alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.24057653
9Butanoate metabolism_Homo sapiens_hsa006502.22051313
10Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.02106986
11Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.00163011
12Primary bile acid biosynthesis_Homo sapiens_hsa001201.92814669
13Nicotine addiction_Homo sapiens_hsa050331.77318702
14Nitrogen metabolism_Homo sapiens_hsa009101.76256718
15Maturity onset diabetes of the young_Homo sapiens_hsa049501.74478976
16Oxidative phosphorylation_Homo sapiens_hsa001901.73810847
17Ether lipid metabolism_Homo sapiens_hsa005651.64928791
18Fatty acid biosynthesis_Homo sapiens_hsa000611.61677345
19RNA polymerase_Homo sapiens_hsa030201.57913632
20Propanoate metabolism_Homo sapiens_hsa006401.55639023
21Tryptophan metabolism_Homo sapiens_hsa003801.54494818
22Fanconi anemia pathway_Homo sapiens_hsa034601.53897304
23Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.53658142
24Homologous recombination_Homo sapiens_hsa034401.53380663
25Allograft rejection_Homo sapiens_hsa053301.49142064
26Selenocompound metabolism_Homo sapiens_hsa004501.48262247
27Autoimmune thyroid disease_Homo sapiens_hsa053201.48153130
28Type I diabetes mellitus_Homo sapiens_hsa049401.47482066
29Taste transduction_Homo sapiens_hsa047421.45921280
30Vitamin B6 metabolism_Homo sapiens_hsa007501.45175876
31Graft-versus-host disease_Homo sapiens_hsa053321.34596493
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.31381533
33African trypanosomiasis_Homo sapiens_hsa051431.30604433
34Retinol metabolism_Homo sapiens_hsa008301.28424706
35Basal transcription factors_Homo sapiens_hsa030221.28270547
36Protein export_Homo sapiens_hsa030601.24442595
37Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.24240936
38Steroid hormone biosynthesis_Homo sapiens_hsa001401.23360380
39ABC transporters_Homo sapiens_hsa020101.18761716
40Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.17869948
41Morphine addiction_Homo sapiens_hsa050321.12237600
42Chemical carcinogenesis_Homo sapiens_hsa052041.11420980
43Sulfur relay system_Homo sapiens_hsa041221.10396154
44Parkinsons disease_Homo sapiens_hsa050121.08910245
45Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.07759286
46Regulation of autophagy_Homo sapiens_hsa041401.05541244
47Intestinal immune network for IgA production_Homo sapiens_hsa046721.01037425
48Peroxisome_Homo sapiens_hsa041460.97186122
49Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.92014308
50Primary immunodeficiency_Homo sapiens_hsa053400.91338171
51Cardiac muscle contraction_Homo sapiens_hsa042600.90546737
52Fat digestion and absorption_Homo sapiens_hsa049750.89144686
53RNA transport_Homo sapiens_hsa030130.88805316
54Salivary secretion_Homo sapiens_hsa049700.87750940
55Collecting duct acid secretion_Homo sapiens_hsa049660.87504660
56Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.85286475
57Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.83787485
58Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.83711006
59Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.83082637
60Huntingtons disease_Homo sapiens_hsa050160.81673870
61Insulin secretion_Homo sapiens_hsa049110.80434492
62Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.78790557
63Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.78650863
64Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.78293054
65GABAergic synapse_Homo sapiens_hsa047270.77411657
66Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.75981256
67Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.75395601
68One carbon pool by folate_Homo sapiens_hsa006700.74212292
69Fatty acid degradation_Homo sapiens_hsa000710.74137830
70Glycerolipid metabolism_Homo sapiens_hsa005610.73660774
71Circadian entrainment_Homo sapiens_hsa047130.72962142
72Serotonergic synapse_Homo sapiens_hsa047260.72674564
73Glutamatergic synapse_Homo sapiens_hsa047240.71396849
74Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.70599317
75Alzheimers disease_Homo sapiens_hsa050100.70044609
76beta-Alanine metabolism_Homo sapiens_hsa004100.67273525
77RNA degradation_Homo sapiens_hsa030180.66743025
78Purine metabolism_Homo sapiens_hsa002300.65850934
79Dorso-ventral axis formation_Homo sapiens_hsa043200.65604843
80Arachidonic acid metabolism_Homo sapiens_hsa005900.64763126
81Metabolic pathways_Homo sapiens_hsa011000.64299738
82Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.64079561
83Glycerophospholipid metabolism_Homo sapiens_hsa005640.63856205
84Carbohydrate digestion and absorption_Homo sapiens_hsa049730.63710460
85Fatty acid metabolism_Homo sapiens_hsa012120.62074377
86Pentose and glucuronate interconversions_Homo sapiens_hsa000400.61820070
87Fatty acid elongation_Homo sapiens_hsa000620.56049037
88Calcium signaling pathway_Homo sapiens_hsa040200.55381468
89Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.54620396
90Pyrimidine metabolism_Homo sapiens_hsa002400.46759224
91Type II diabetes mellitus_Homo sapiens_hsa049300.46034757
92Ovarian steroidogenesis_Homo sapiens_hsa049130.45565329
93Asthma_Homo sapiens_hsa053100.42249177
94cAMP signaling pathway_Homo sapiens_hsa040240.37947501
95Base excision repair_Homo sapiens_hsa034100.36076299
96Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.34826857
97Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.33622573
98Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.32129480
99Arginine and proline metabolism_Homo sapiens_hsa003300.31648166
100Cysteine and methionine metabolism_Homo sapiens_hsa002700.31382190

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