ACTG1P18

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of female receptivity (GO:0045924)5.77965171
2fat-soluble vitamin catabolic process (GO:0042363)5.01129913
3vitamin catabolic process (GO:0009111)5.01129913
4female mating behavior (GO:0060180)4.75812179
5negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)4.56035085
6positive regulation of inositol phosphate biosynthetic process (GO:0060732)4.52382859
7detection of light stimulus involved in visual perception (GO:0050908)4.46329000
8detection of light stimulus involved in sensory perception (GO:0050962)4.46329000
9glycosphingolipid biosynthetic process (GO:0006688)4.39213194
10negative regulation of dendrite development (GO:2000171)4.39093875
11adenosine metabolic process (GO:0046085)4.18320024
12auditory behavior (GO:0031223)4.03716754
13acrosome reaction (GO:0007340)3.83680474
14lymphangiogenesis (GO:0001946)3.80026723
15heparin metabolic process (GO:0030202)3.79909742
16heparin biosynthetic process (GO:0030210)3.79909742
17aggressive behavior (GO:0002118)3.78709628
18regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.77848290
19regulation of DNA endoreduplication (GO:0032875)3.69981113
20skeletal muscle tissue regeneration (GO:0043403)3.64765253
21positive regulation of cAMP-mediated signaling (GO:0043950)3.60705632
22otic vesicle formation (GO:0030916)3.59024311
23DNA deamination (GO:0045006)3.55481732
24inositol phosphate-mediated signaling (GO:0048016)3.50896831
25mature B cell differentiation involved in immune response (GO:0002313)3.48631278
26response to methylmercury (GO:0051597)3.46692134
27negative regulation of execution phase of apoptosis (GO:1900118)3.44693883
28neuronal action potential (GO:0019228)3.42100052
29retinal cone cell development (GO:0046549)3.38703235
30protein polyglutamylation (GO:0018095)3.38263252
31positive regulation of glomerulus development (GO:0090193)3.36620507
32synaptic transmission, dopaminergic (GO:0001963)3.34504407
33L-fucose catabolic process (GO:0042355)3.29860941
34fucose catabolic process (GO:0019317)3.29860941
35L-fucose metabolic process (GO:0042354)3.29860941
36negative regulation of cytosolic calcium ion concentration (GO:0051481)3.26920608
37C4-dicarboxylate transport (GO:0015740)3.24752231
38protein targeting to lysosome (GO:0006622)3.24199684
39establishment of protein localization to vacuole (GO:0072666)3.24199684
40protein targeting to vacuole (GO:0006623)3.24199684
41maturation of 5.8S rRNA (GO:0000460)3.19576891
42pantothenate metabolic process (GO:0015939)3.16966858
43primary amino compound metabolic process (GO:1901160)3.16454205
44mitotic G2 DNA damage checkpoint (GO:0007095)3.15837437
45serotonin metabolic process (GO:0042428)3.13766602
46protein localization to cilium (GO:0061512)3.10306972
47anterior/posterior axis specification, embryo (GO:0008595)3.04509542
48regulation of glomerulus development (GO:0090192)3.03433331
49retinal ganglion cell axon guidance (GO:0031290)3.02131615
50zinc ion transport (GO:0006829)3.00686614
51regulation of inositol phosphate biosynthetic process (GO:0010919)2.99186819
52behavioral response to nicotine (GO:0035095)2.96146991
53mechanosensory behavior (GO:0007638)2.91745134
54negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.91410757
55negative regulation of translation, ncRNA-mediated (GO:0040033)2.91410757
56regulation of translation, ncRNA-mediated (GO:0045974)2.91410757
57detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)2.91095690
58response to amphetamine (GO:0001975)2.85304958
59regulation of penile erection (GO:0060405)2.82607713
60indole-containing compound catabolic process (GO:0042436)2.81984667
61indolalkylamine catabolic process (GO:0046218)2.81984667
62tryptophan catabolic process (GO:0006569)2.81984667
63attachment of spindle microtubules to kinetochore (GO:0008608)2.81098148
64kynurenine metabolic process (GO:0070189)2.77949946
65mature B cell differentiation (GO:0002335)2.75100779
66indolalkylamine metabolic process (GO:0006586)2.74976719
67cornea development in camera-type eye (GO:0061303)2.74769937
68adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.74647515
69preassembly of GPI anchor in ER membrane (GO:0016254)2.74491092
70negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)2.73193402
71response to auditory stimulus (GO:0010996)2.70530582
72cell morphogenesis involved in neuron differentiation (GO:0048667)2.70418157
73ovulation cycle (GO:0042698)2.69641751
74glycosylceramide metabolic process (GO:0006677)2.68120012
75eye photoreceptor cell development (GO:0042462)2.67319846
76venous blood vessel morphogenesis (GO:0048845)2.65112505
77photoreceptor cell development (GO:0042461)2.63240196
78exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.62541069
79tryptophan metabolic process (GO:0006568)2.61417929
80indole-containing compound metabolic process (GO:0042430)2.61171123
81regulation of sensory perception (GO:0051931)2.60828654
82regulation of sensory perception of pain (GO:0051930)2.60828654
83RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.59561356
84detection of chemical stimulus involved in sensory perception of taste (GO:0050912)2.59374452
85response to cocaine (GO:0042220)2.55532450
86visual perception (GO:0007601)2.54632870
87endoderm formation (GO:0001706)2.52821574
88transmission of nerve impulse (GO:0019226)2.51777362
89photoreceptor cell maintenance (GO:0045494)2.51570888
90sensory perception of light stimulus (GO:0050953)2.51081603
91sensory perception of smell (GO:0007608)2.50952680
92positive regulation of mRNA processing (GO:0050685)2.50361485
93activated T cell proliferation (GO:0050798)2.50154058
94cyclic nucleotide catabolic process (GO:0009214)2.49267615
95retinol metabolic process (GO:0042572)2.45855980
96long term synaptic depression (GO:0060292)2.45508608
97cellular glucuronidation (GO:0052695)2.45373098
98nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.42897364
99positive regulation of mRNA 3-end processing (GO:0031442)2.42647222
100regulation of neuron migration (GO:2001222)2.41032762

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.19442212
2GBX2_23144817_ChIP-Seq_PC3_Human3.43275162
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.23380343
4ZFP57_27257070_Chip-Seq_ESCs_Mouse3.09549902
5POU3F2_20337985_ChIP-ChIP_501MEL_Human2.93073995
6NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.77683999
7FUS_26573619_Chip-Seq_HEK293_Human2.67614221
8EWS_26573619_Chip-Seq_HEK293_Human2.47002846
9BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.46640627
10CTBP2_25329375_ChIP-Seq_LNCAP_Human2.38254612
11FLI1_27457419_Chip-Seq_LIVER_Mouse2.35030523
12IGF1R_20145208_ChIP-Seq_DFB_Human2.34220466
13AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.27096201
14CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.22946705
15P300_19829295_ChIP-Seq_ESCs_Human2.08795881
16PCGF2_27294783_Chip-Seq_ESCs_Mouse1.95941781
17PIAS1_25552417_ChIP-Seq_VCAP_Human1.95134698
18PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.95026893
19IRF1_19129219_ChIP-ChIP_H3396_Human1.92449517
20SMAD4_21799915_ChIP-Seq_A2780_Human1.91920269
21HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.91585689
22BCAT_22108803_ChIP-Seq_LS180_Human1.86644684
23SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.85916371
24SMAD3_21741376_ChIP-Seq_EPCs_Human1.85230547
25STAT3_23295773_ChIP-Seq_U87_Human1.82577732
26CTBP1_25329375_ChIP-Seq_LNCAP_Human1.81201321
27POU5F1_16153702_ChIP-ChIP_HESCs_Human1.80050564
28ER_23166858_ChIP-Seq_MCF-7_Human1.78447775
29MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.68746789
30SALL1_21062744_ChIP-ChIP_HESCs_Human1.64338769
31SUZ12_27294783_Chip-Seq_NPCs_Mouse1.61526466
32TAF15_26573619_Chip-Seq_HEK293_Human1.61274218
33TCF4_23295773_ChIP-Seq_U87_Human1.55095823
34ZNF274_21170338_ChIP-Seq_K562_Hela1.54864102
35SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.54043214
36EZH2_27294783_Chip-Seq_NPCs_Mouse1.53140765
37UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.52058783
38NFE2_27457419_Chip-Seq_LIVER_Mouse1.51790535
39TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.47140774
40E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.46766550
41CBP_20019798_ChIP-Seq_JUKART_Human1.46266964
42IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.46266964
43AR_25329375_ChIP-Seq_VCAP_Human1.45838446
44SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.43931405
45NR3C1_21868756_ChIP-Seq_MCF10A_Human1.42629483
46HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.42248228
47MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.39210018
48TOP2B_26459242_ChIP-Seq_MCF-7_Human1.38476738
49SMAD_19615063_ChIP-ChIP_OVARY_Human1.37584537
50RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.35333351
51EED_16625203_ChIP-ChIP_MESCs_Mouse1.33018199
52CRX_20693478_ChIP-Seq_RETINA_Mouse1.32732707
53CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.31900575
54ARNT_22903824_ChIP-Seq_MCF-7_Human1.28823837
55ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.28781524
56SOX2_21211035_ChIP-Seq_LN229_Gbm1.28686766
57AR_21572438_ChIP-Seq_LNCaP_Human1.27933237
58ELK1_19687146_ChIP-ChIP_HELA_Human1.26724074
59OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26656082
60E2F1_18555785_Chip-Seq_ESCs_Mouse1.26276022
61P53_22387025_ChIP-Seq_ESCs_Mouse1.25535952
62VDR_22108803_ChIP-Seq_LS180_Human1.25319553
63CBX2_27304074_Chip-Seq_ESCs_Mouse1.25246386
64SMAD4_21741376_ChIP-Seq_EPCs_Human1.24206832
65RNF2_27304074_Chip-Seq_NSC_Mouse1.22785167
66TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.22402884
67PCGF2_27294783_Chip-Seq_NPCs_Mouse1.20122059
68SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.19993600
69REST_21632747_ChIP-Seq_MESCs_Mouse1.19585633
70FLI1_21867929_ChIP-Seq_TH2_Mouse1.19324542
71NANOG_18555785_Chip-Seq_ESCs_Mouse1.18311652
72RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.18052487
73EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.17418884
74BMI1_23680149_ChIP-Seq_NPCS_Mouse1.15437285
75ETV1_20927104_ChIP-Seq_GIST48_Human1.15432423
76SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.15225181
77TCF4_22108803_ChIP-Seq_LS180_Human1.14971833
78EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.13995284
79AHR_22903824_ChIP-Seq_MCF-7_Human1.13465084
80TBL1_22424771_ChIP-Seq_293T_Human1.10981330
81TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.10803173
82EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.10794093
83JUN_21703547_ChIP-Seq_K562_Human1.10587981
84NANOG_19829295_ChIP-Seq_ESCs_Human1.09572623
85SOX2_19829295_ChIP-Seq_ESCs_Human1.09572623
86OCT4_21477851_ChIP-Seq_ESCs_Mouse1.08049797
87STAT3_18555785_Chip-Seq_ESCs_Mouse1.07864134
88SOX2_18555785_Chip-Seq_ESCs_Mouse1.06554709
89TDRD3_21172665_ChIP-Seq_MCF-7_Human1.05503435
90TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.05406291
91PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.05237713
92KLF5_20875108_ChIP-Seq_MESCs_Mouse1.04016544
93KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.03796200
94NRF2_20460467_ChIP-Seq_MEFs_Mouse1.03286385
95NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.03286385
96KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.02790631
97P300_18555785_Chip-Seq_ESCs_Mouse1.02241598
98IRF8_22096565_ChIP-ChIP_GC-B_Human1.02147594
99TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.01770833
100SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.01411590

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002736_abnormal_nociception_after4.01385575
2MP0001968_abnormal_touch/_nociception3.63103747
3MP0002653_abnormal_ependyma_morphology3.22464387
4MP0005083_abnormal_biliary_tract2.95847984
5MP0002163_abnormal_gland_morphology2.84166861
6MP0005379_endocrine/exocrine_gland_phen2.69895774
7MP0005646_abnormal_pituitary_gland2.61247607
8MP0006072_abnormal_retinal_apoptosis2.59450750
9MP0003172_abnormal_lysosome_physiology2.53768315
10MP0006292_abnormal_olfactory_placode2.50030052
11MP0005551_abnormal_eye_electrophysiolog2.43479503
12MP0005360_urolithiasis2.41599404
13MP0002909_abnormal_adrenal_gland2.35416682
14MP0001346_abnormal_lacrimal_gland2.34496585
15MP0005171_absent_coat_pigmentation2.19056920
16MP0005248_abnormal_Harderian_gland2.10650246
17MP0002837_dystrophic_cardiac_calcinosis2.08577830
18MP0005253_abnormal_eye_physiology2.04780177
19MP0006276_abnormal_autonomic_nervous1.91947077
20MP0002734_abnormal_mechanical_nocicepti1.90347705
21MP0001984_abnormal_olfaction1.87900606
22MP0001324_abnormal_eye_pigmentation1.84396344
23MP0009780_abnormal_chondrocyte_physiolo1.77021057
24MP0003646_muscle_fatigue1.70952945
25MP0002928_abnormal_bile_duct1.69070854
26MP0000631_abnormal_neuroendocrine_gland1.61372995
27MP0000538_abnormal_urinary_bladder1.57266195
28MP0009046_muscle_twitch1.56526124
29MP0005389_reproductive_system_phenotype1.56449556
30MP0004270_analgesia1.55355161
31MP0009697_abnormal_copulation1.54906790
32MP0001919_abnormal_reproductive_system1.54349802
33MP0005195_abnormal_posterior_eye1.44012025
34MP0004215_abnormal_myocardial_fiber1.38964385
35MP0004142_abnormal_muscle_tone1.38679057
36MP0002272_abnormal_nervous_system1.37394464
37MP0009745_abnormal_behavioral_response1.34611441
38MP0002160_abnormal_reproductive_system1.33934614
39MP0005367_renal/urinary_system_phenotyp1.32921479
40MP0000516_abnormal_urinary_system1.32921479
41MP0005409_darkened_coat_color1.32578997
42MP0009250_abnormal_appendicular_skeleto1.29347765
43MP0010352_gastrointestinal_tract_polyps1.26649238
44MP0001970_abnormal_pain_threshold1.20929727
45MP0001502_abnormal_circadian_rhythm1.20858945
46MP0004084_abnormal_cardiac_muscle1.18880088
47MP0002876_abnormal_thyroid_physiology1.17997293
48MP0005187_abnormal_penis_morphology1.17306863
49MP0000613_abnormal_salivary_gland1.15177450
50MP0003045_fibrosis1.13774200
51MP0004036_abnormal_muscle_relaxation1.10613286
52MP0002127_abnormal_cardiovascular_syste1.09936262
53MP0002557_abnormal_social/conspecific_i1.06182448
54MP0008872_abnormal_physiological_respon1.03736868
55MP0002233_abnormal_nose_morphology1.00174602
56MP0002064_seizures0.99956832
57MP0002572_abnormal_emotion/affect_behav0.99908277
58MP0002752_abnormal_somatic_nervous0.97432829
59MP0008789_abnormal_olfactory_epithelium0.95805678
60MP0002090_abnormal_vision0.95243405
61MP0002168_other_aberrant_phenotype0.93495518
62MP0000049_abnormal_middle_ear0.92472532
63MP0002063_abnormal_learning/memory/cond0.91027583
64MP0001440_abnormal_grooming_behavior0.90607481
65MP0005084_abnormal_gallbladder_morpholo0.90134756
66MP0003718_maternal_effect0.88755220
67MP0005391_vision/eye_phenotype0.88744730
68MP0004134_abnormal_chest_morphology0.87819176
69MP0010329_abnormal_lipoprotein_level0.87568842
70MP0003890_abnormal_embryonic-extraembry0.87541295
71MP0003787_abnormal_imprinting0.86869863
72MP0001879_abnormal_lymphatic_vessel0.85372897
73MP0001486_abnormal_startle_reflex0.85221858
74MP0008875_abnormal_xenobiotic_pharmacok0.84618911
75MP0001348_abnormal_lacrimal_gland0.84345846
76MP0005395_other_phenotype0.83022606
77MP0004924_abnormal_behavior0.82996498
78MP0005386_behavior/neurological_phenoty0.82996498
79MP0004484_altered_response_of0.82733465
80MP0002102_abnormal_ear_morphology0.81018923
81MP0003283_abnormal_digestive_organ0.80433845
82MP0002138_abnormal_hepatobiliary_system0.78880167
83MP0003937_abnormal_limbs/digits/tail_de0.76964258
84MP0002733_abnormal_thermal_nociception0.76613355
85MP0001764_abnormal_homeostasis0.75982247
86MP0004859_abnormal_synaptic_plasticity0.75923871
87MP0008775_abnormal_heart_ventricle0.74695874
88MP0002882_abnormal_neuron_morphology0.74297211
89MP0010386_abnormal_urinary_bladder0.74078400
90MP0008877_abnormal_DNA_methylation0.73870440
91MP0005075_abnormal_melanosome_morpholog0.71472061
92MP0002735_abnormal_chemical_nociception0.71380914
93MP0003119_abnormal_digestive_system0.69920607
94MP0002229_neurodegeneration0.69189032
95MP0000462_abnormal_digestive_system0.67582104
96MP0001501_abnormal_sleep_pattern0.67557673
97MP0001963_abnormal_hearing_physiology0.66319355
98MP0002067_abnormal_sensory_capabilities0.65487146
99MP0003635_abnormal_synaptic_transmissio0.64915809
100MP0003122_maternal_imprinting0.64694839

Predicted human phenotypes

RankGene SetZ-score
1True hermaphroditism (HP:0010459)4.42560536
2Pancreatic fibrosis (HP:0100732)4.33966952
3Abolished electroretinogram (ERG) (HP:0000550)4.29556073
4Pancreatic cysts (HP:0001737)4.26118423
5Keratoconus (HP:0000563)4.14593942
6Increased corneal curvature (HP:0100692)4.14593942
7Decreased central vision (HP:0007663)4.09167642
8Nephronophthisis (HP:0000090)3.53552215
9Chorioretinal atrophy (HP:0000533)3.40649875
10Attenuation of retinal blood vessels (HP:0007843)3.39242994
11Absent/shortened dynein arms (HP:0200106)3.27853254
12Dynein arm defect of respiratory motile cilia (HP:0012255)3.27853254
13Hepatoblastoma (HP:0002884)3.19875926
14Molar tooth sign on MRI (HP:0002419)3.19706589
15Abnormality of midbrain morphology (HP:0002418)3.19706589
16Aplasia/Hypoplasia of the tongue (HP:0010295)3.13221022
17Abnormality of the phalanges of the 2nd finger (HP:0009541)3.13098017
18Furrowed tongue (HP:0000221)3.11795550
19Abnormality of the proximal phalanges of the hand (HP:0009834)3.10124275
20Bony spicule pigmentary retinopathy (HP:0007737)3.08607742
21Poor head control (HP:0002421)3.06118762
22Congenital stationary night blindness (HP:0007642)3.01165439
23Failure to thrive in infancy (HP:0001531)2.99802891
24Hypoplasia of the uterus (HP:0000013)2.94391904
25Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.88450477
26Short 1st metacarpal (HP:0010034)2.88450477
27Neoplasm of the adrenal cortex (HP:0100641)2.87887363
28Absent rod-and cone-mediated responses on ERG (HP:0007688)2.85353670
29Oligodactyly (hands) (HP:0001180)2.76681951
30Cystic liver disease (HP:0006706)2.75457766
31Stenosis of the external auditory canal (HP:0000402)2.73752472
32Decreased electroretinogram (ERG) amplitude (HP:0000654)2.69230571
33Abnormality of the renal medulla (HP:0100957)2.66926262
34Constricted visual fields (HP:0001133)2.50879241
35Abnormality of the 1st metacarpal (HP:0010009)2.50781685
36Type II lissencephaly (HP:0007260)2.49121304
37Congenital hepatic fibrosis (HP:0002612)2.46528330
38Occipital encephalocele (HP:0002085)2.46412062
39Mesangial abnormality (HP:0001966)2.45081868
40Abnormality of the costochondral junction (HP:0000919)2.38429700
41Abnormality of cochlea (HP:0000375)2.38114966
42Colon cancer (HP:0003003)2.37085729
43Short hallux (HP:0010109)2.35914835
44Symphalangism affecting the phalanges of the hand (HP:0009773)2.34366030
45Long clavicles (HP:0000890)2.34150985
46Progressive inability to walk (HP:0002505)2.32638770
47Abnormality of the labia minora (HP:0012880)2.28522148
48Chronic hepatic failure (HP:0100626)2.26655832
49Severe Myopia (HP:0011003)2.24898612
50Abnormality of the middle phalanges of the toes (HP:0010183)2.24215353
51Inability to walk (HP:0002540)2.22322396
52Aplasia/hypoplasia of the uterus (HP:0008684)2.21665923
53Morphological abnormality of the inner ear (HP:0011390)2.20326919
54Medial flaring of the eyebrow (HP:0010747)2.18530264
55Methylmalonic aciduria (HP:0012120)2.18095455
56Aplasia/Hypoplasia of the hallux (HP:0008362)2.17696582
57Abnormality of aspartate family amino acid metabolism (HP:0010899)2.16680981
58Birth length less than 3rd percentile (HP:0003561)2.14369922
59Action tremor (HP:0002345)2.12581525
60Hyperventilation (HP:0002883)2.11914695
61Intestinal atresia (HP:0011100)2.04602696
62Postaxial hand polydactyly (HP:0001162)2.03682493
63Alacrima (HP:0000522)2.02956007
64Macular degeneration (HP:0000608)2.02844349
65Epidermoid cyst (HP:0200040)1.99645976
66Abnormal respiratory epithelium morphology (HP:0012253)1.99246351
67Abnormal respiratory motile cilium morphology (HP:0005938)1.99246351
68Abnormality of the 2nd finger (HP:0004100)1.99219480
69Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.98674008
70Sclerocornea (HP:0000647)1.98465507
71Thyroiditis (HP:0100646)1.97736804
72Pendular nystagmus (HP:0012043)1.96721810
73Anencephaly (HP:0002323)1.94855607
74Astigmatism (HP:0000483)1.93509193
75Abnormal rod and cone electroretinograms (HP:0008323)1.93274798
76Abnormality of chromosome stability (HP:0003220)1.92972006
77Methylmalonic acidemia (HP:0002912)1.92947361
78Acute encephalopathy (HP:0006846)1.92813157
79Tinnitus (HP:0000360)1.92628700
80Gonadotropin excess (HP:0000837)1.92297542
81Decreased lacrimation (HP:0000633)1.90988895
82Renal cortical cysts (HP:0000803)1.90333943
83Hypoalbuminemia (HP:0003073)1.90130091
84Abnormal albumin level (HP:0012116)1.90130091
85Hypoplasia of the ulna (HP:0003022)1.89936128
86Posterior subcapsular cataract (HP:0007787)1.89706046
87Broad-based gait (HP:0002136)1.89530530
88Preaxial hand polydactyly (HP:0001177)1.88937505
89Lymphangioma (HP:0100764)1.88144431
90Dysautonomia (HP:0002459)1.84724340
91Labial hypoplasia (HP:0000066)1.83958255
92Male pseudohermaphroditism (HP:0000037)1.83691712
93Oligodactyly (HP:0012165)1.83601598
94Aqueductal stenosis (HP:0002410)1.83046352
95Widely patent fontanelles and sutures (HP:0004492)1.79153971
96B lymphocytopenia (HP:0010976)1.76483299
97Hemiparesis (HP:0001269)1.76435306
98Cerebellar dysplasia (HP:0007033)1.76387870
99Abnormality of the renal cortex (HP:0011035)1.75510460
100Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.74422490

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NEK14.85376218
2NUAK14.30184481
3FRK4.18544892
4TRIM283.37563051
5BUB13.36841833
6BCR2.68411544
7WNK32.66644054
8MAP4K22.53645477
9STK162.36504244
10PLK42.26844422
11MAP3K42.25415173
12CAMKK22.18983626
13CCNB12.01626042
14BMPR1B1.89625330
15CSNK1G21.78135180
16ACVR1B1.77718830
17CSNK1G31.70210958
18FGFR21.70000407
19NTRK11.69211577
20CSNK1A1L1.68293054
21CDK191.66357589
22AKT31.63361801
23ZAK1.56746172
24BRSK21.50394210
25MAP2K21.48278863
26MKNK21.47170848
27PLK21.45919030
28CSNK1G11.45917918
29ERBB31.45824455
30NTRK21.44471817
31GRK11.34545603
32ADRBK21.34336085
33TNIK1.32647815
34SIK31.28644240
35PAK31.27870390
36STK31.27755427
37CASK1.26622684
38MINK11.10014080
39TLK11.06380156
40STK381.05197544
41NEK21.05065094
42TAOK30.93654774
43BRSK10.93044850
44MAP2K10.85405527
45VRK10.76897267
46TAF10.71300938
47CAMK2D0.70006192
48CAMK2A0.69809336
49INSRR0.67754929
50DDR20.64784650
51ADRBK10.61473118
52PRKCE0.60947448
53PIK3CA0.59190032
54MAPK130.59003681
55MUSK0.55449339
56DYRK1A0.55245661
57MAP3K30.55068877
58FER0.53419356
59NLK0.52359986
60PRKCG0.49897262
61CAMK2B0.49879186
62MKNK10.48519185
63DMPK0.45418387
64PKN10.44892736
65ROCK10.42239167
66VRK20.41924480
67OBSCN0.41886906
68PHKG10.41880681
69PHKG20.41880681
70MAP2K70.37758466
71PRKACG0.37218253
72PRKCZ0.36835471
73GSK3A0.36134942
74PLK30.35273266
75OXSR10.33828248
76PDK20.33224620
77EPHA30.32729519
78PRKACA0.30565556
79CSNK1D0.30099718
80TGFBR20.30031533
81PTK2B0.30019751
82LATS10.29950571
83IRAK10.28103656
84CSNK1A10.27791146
85PINK10.27618150
86GRK50.27143913
87MYLK0.27133386
88PRKG10.25770939
89NTRK30.22973914
90PRKACB0.22786778
91CAMK10.22421846
92PRKCA0.21090836
93CAMK40.20671214
94PRKDC0.20157041
95DYRK20.19820295
96CAMKK10.18919275
97BRD40.18470212
98UHMK10.18070650
99PRKCB0.18013538
100RPS6KA30.17110612

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.70307333
2Phototransduction_Homo sapiens_hsa047442.98533779
3Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.73613978
4Olfactory transduction_Homo sapiens_hsa047402.55418478
5Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.44083598
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.28846126
7Retinol metabolism_Homo sapiens_hsa008302.24696059
8Nicotine addiction_Homo sapiens_hsa050332.07637247
9Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.02920849
10Taste transduction_Homo sapiens_hsa047421.94332754
11Intestinal immune network for IgA production_Homo sapiens_hsa046721.93320454
12Sulfur metabolism_Homo sapiens_hsa009201.82615578
13Chemical carcinogenesis_Homo sapiens_hsa052041.76960327
14Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.73739097
15Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.71979600
16Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.71428107
17Homologous recombination_Homo sapiens_hsa034401.66963678
18Protein export_Homo sapiens_hsa030601.66011104
19Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.61536649
20Propanoate metabolism_Homo sapiens_hsa006401.60971573
21Vitamin B6 metabolism_Homo sapiens_hsa007501.58023576
22Ether lipid metabolism_Homo sapiens_hsa005651.57120956
23RNA polymerase_Homo sapiens_hsa030201.54507551
24Pentose and glucuronate interconversions_Homo sapiens_hsa000401.53718252
25Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.50687133
26Steroid hormone biosynthesis_Homo sapiens_hsa001401.50249538
27Asthma_Homo sapiens_hsa053101.47086269
28RNA degradation_Homo sapiens_hsa030181.42731041
29SNARE interactions in vesicular transport_Homo sapiens_hsa041301.40643246
30Maturity onset diabetes of the young_Homo sapiens_hsa049501.37358257
31Insulin secretion_Homo sapiens_hsa049111.36271131
32Steroid biosynthesis_Homo sapiens_hsa001001.35850429
33Lysine degradation_Homo sapiens_hsa003101.33657309
34Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.30398687
35Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.29554852
36Type I diabetes mellitus_Homo sapiens_hsa049401.29267339
37Morphine addiction_Homo sapiens_hsa050321.24501455
38Circadian entrainment_Homo sapiens_hsa047131.11200019
39Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.08256774
40Systemic lupus erythematosus_Homo sapiens_hsa053221.05878402
41Glutamatergic synapse_Homo sapiens_hsa047241.05025500
42Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.03669250
43Fanconi anemia pathway_Homo sapiens_hsa034601.03307176
44beta-Alanine metabolism_Homo sapiens_hsa004101.02482959
45Calcium signaling pathway_Homo sapiens_hsa040200.99803128
46Butanoate metabolism_Homo sapiens_hsa006500.97437109
47Starch and sucrose metabolism_Homo sapiens_hsa005000.89416472
48Oxidative phosphorylation_Homo sapiens_hsa001900.85685830
49GABAergic synapse_Homo sapiens_hsa047270.83313731
50Graft-versus-host disease_Homo sapiens_hsa053320.81845759
51Tryptophan metabolism_Homo sapiens_hsa003800.81590004
52Allograft rejection_Homo sapiens_hsa053300.80989940
53Autoimmune thyroid disease_Homo sapiens_hsa053200.80895134
54Peroxisome_Homo sapiens_hsa041460.80282248
55Glycerolipid metabolism_Homo sapiens_hsa005610.78764824
56Histidine metabolism_Homo sapiens_hsa003400.77648626
57Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.73095212
58Drug metabolism - other enzymes_Homo sapiens_hsa009830.71432221
59Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.69681024
60Serotonergic synapse_Homo sapiens_hsa047260.69632927
61Linoleic acid metabolism_Homo sapiens_hsa005910.67848227
62Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.66741931
63Dopaminergic synapse_Homo sapiens_hsa047280.65388378
64Arachidonic acid metabolism_Homo sapiens_hsa005900.64040245
65Cocaine addiction_Homo sapiens_hsa050300.63826543
66Parkinsons disease_Homo sapiens_hsa050120.63687581
67Hedgehog signaling pathway_Homo sapiens_hsa043400.63195001
68Primary bile acid biosynthesis_Homo sapiens_hsa001200.63004526
69Glycosaminoglycan degradation_Homo sapiens_hsa005310.62567112
70Caffeine metabolism_Homo sapiens_hsa002320.62102854
71Alcoholism_Homo sapiens_hsa050340.61557177
72Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.60802307
73Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.58674857
74Non-homologous end-joining_Homo sapiens_hsa034500.58049611
75Cardiac muscle contraction_Homo sapiens_hsa042600.57932416
76cAMP signaling pathway_Homo sapiens_hsa040240.57806906
77Metabolic pathways_Homo sapiens_hsa011000.55511967
78Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.52501580
79Amphetamine addiction_Homo sapiens_hsa050310.52392712
80Mineral absorption_Homo sapiens_hsa049780.52253847
81Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.52127625
82Glycerophospholipid metabolism_Homo sapiens_hsa005640.50137672
83Circadian rhythm_Homo sapiens_hsa047100.49413728
84Collecting duct acid secretion_Homo sapiens_hsa049660.49153668
85ABC transporters_Homo sapiens_hsa020100.48847883
86Glutathione metabolism_Homo sapiens_hsa004800.47750279
87Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.47255906
88Oxytocin signaling pathway_Homo sapiens_hsa049210.45829347
89Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.45273506
90Alzheimers disease_Homo sapiens_hsa050100.44831957
91Fatty acid metabolism_Homo sapiens_hsa012120.43018791
92Gastric acid secretion_Homo sapiens_hsa049710.42045436
93TGF-beta signaling pathway_Homo sapiens_hsa043500.41350905
94Salivary secretion_Homo sapiens_hsa049700.39684245
95Transcriptional misregulation in cancer_Homo sapiens_hsa052020.38940095
96Dilated cardiomyopathy_Homo sapiens_hsa054140.38754762
97Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.38313077
98Renin secretion_Homo sapiens_hsa049240.36569235
99Melanoma_Homo sapiens_hsa052180.30003811
100alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.29636685

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