ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	6.21105981
2	protein neddylation (GO:0045116)	5.33217377
3	proteasome assembly (GO:0043248)	4.85673214
4	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	4.41214588
5	cytidine metabolic process (GO:0046087)	4.07183096
6	cytidine catabolic process (GO:0006216)	4.07183096
7	cytidine deamination (GO:0009972)	4.07183096
8	regulation of cellular amino acid metabolic process (GO:0006521)	3.94742033
9	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.90464829
10	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	3.81592062
11	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	3.75741704
12	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	3.75741704
13	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	3.75741704
14	protein deneddylation (GO:0000338)	3.73140745
15	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	3.70890444
16	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	3.70890444
17	regulation of mitotic spindle checkpoint (GO:1903504)	3.62456046
18	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	3.62456046
19	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.60262021
20	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.59378510
21	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.59378510
22	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.58680297
23	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.58537025
24	ATP synthesis coupled proton transport (GO:0015986)	3.58537025
25	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.58347222
26	respiratory chain complex IV assembly (GO:0008535)	3.53981716
27	signal transduction involved in DNA damage checkpoint (GO:0072422)	3.53815050
28	signal transduction involved in DNA integrity checkpoint (GO:0072401)	3.53815050
29	cullin deneddylation (GO:0010388)	3.51978163
30	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	3.51688646
31	pyrimidine ribonucleoside catabolic process (GO:0046133)	3.50644212
32	signal transduction involved in cell cycle checkpoint (GO:0072395)	3.49150726
33	water-soluble vitamin biosynthetic process (GO:0042364)	3.48828099
34	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	3.44281496
35	negative regulation of ligase activity (GO:0051352)	3.41575750
36	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	3.41575750
37	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:	3.41024542
38	antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)	3.28596187
39	platelet dense granule organization (GO:0060155)	3.13972226
40	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	3.11109361
41	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.10507228
42	Arp2/3 complex-mediated actin nucleation (GO:0034314)	3.07264895
43	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.05272527
44	mast cell activation (GO:0045576)	3.04372740
45	protein complex biogenesis (GO:0070271)	2.94120333
46	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	2.92821101
47	mast cell degranulation (GO:0043303)	2.91478465
48	mast cell activation involved in immune response (GO:0002279)	2.91478465
49	cytochrome complex assembly (GO:0017004)	2.91053843
50	positive regulation of ligase activity (GO:0051351)	2.88630919
51	antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)	2.88414087
52	regulation of cellular amine metabolic process (GO:0033238)	2.86818286
53	chaperone-mediated protein transport (GO:0072321)	2.86499615
54	DNA catabolic process, exonucleolytic (GO:0000738)	2.85932956
55	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.85687676
56	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.85687676
57	NADH dehydrogenase complex assembly (GO:0010257)	2.85687676
58	negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)	2.85205013
59	positive regulation of cell cycle arrest (GO:0071158)	2.84909215
60	regulation of chronic inflammatory response (GO:0002676)	2.83806142
61	mitochondrial respiratory chain complex assembly (GO:0033108)	2.82119102
62	actin nucleation (GO:0045010)	2.81106608
63	purine deoxyribonucleotide catabolic process (GO:0009155)	2.80469967
64	positive regulation of alpha-beta T cell proliferation (GO:0046641)	2.78888226
65	rRNA modification (GO:0000154)	2.78601142
66	DNA double-strand break processing (GO:0000729)	2.76427334
67	indole-containing compound catabolic process (GO:0042436)	2.76354457
68	indolalkylamine catabolic process (GO:0046218)	2.76354457
69	tryptophan catabolic process (GO:0006569)	2.76354457
70	purine nucleobase biosynthetic process (GO:0009113)	2.72705162
71	rRNA methylation (GO:0031167)	2.72172611
72	DNA damage response, signal transduction by p53 class mediator (GO:0030330)	2.70129929
73	respiratory electron transport chain (GO:0022904)	2.69384281
74	electron transport chain (GO:0022900)	2.68960473
75	regulation of isotype switching to IgG isotypes (GO:0048302)	2.67643847
76	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.67001090
77	termination of RNA polymerase III transcription (GO:0006386)	2.67001090
78	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.65762003
79	regulation of B cell receptor signaling pathway (GO:0050855)	2.65639848
80	behavioral response to nicotine (GO:0035095)	2.65559861
81	negative T cell selection (GO:0043383)	2.64253315
82	DNA damage response, detection of DNA damage (GO:0042769)	2.62912813
83	negative regulation of calcium ion transport into cytosol (GO:0010523)	2.62172752
84	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	2.60194327
85	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.58570060
86	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.58570060
87	isotype switching (GO:0045190)	2.58570060
88	B cell mediated immunity (GO:0019724)	2.57273277
89	protein-cofactor linkage (GO:0018065)	2.57023669
90	adenosine metabolic process (GO:0046085)	2.56019632
91	kynurenine metabolic process (GO:0070189)	2.54962957
92	cellular response to interleukin-15 (GO:0071350)	2.53116479
93	IMP biosynthetic process (GO:0006188)	2.51821123
94	positive regulation of T cell mediated cytotoxicity (GO:0001916)	2.51512687
95	regulation of alpha-beta T cell proliferation (GO:0046640)	2.49898566
96	positive regulation of defense response to virus by host (GO:0002230)	2.46057117
97	positive regulation of DNA recombination (GO:0045911)	2.45965812
98	purine nucleotide salvage (GO:0032261)	2.43550882
99	regulation of ubiquitin-protein transferase activity (GO:0051438)	2.43428105
100	sulfation (GO:0051923)	2.43271216

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.66194070
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.20119268
3	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.57487045
4	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.31259580
5	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.85394149
6	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	2.77189935
7	VDR_22108803_ChIP-Seq_LS180_Human	2.76123320
8	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	2.75855263
9	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.73958887
10	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.66920923
11	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.62454629
12	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.60206247
13	VDR_23849224_ChIP-Seq_CD4+_Human	2.54276942
14	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.53250486
15	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.42555297
16	IRF8_21731497_ChIP-ChIP_J774_Mouse	2.31022114
17	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.29371592
18	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.27765759
19	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.20319303
20	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.15303492
21	ELK1_19687146_ChIP-ChIP_HELA_Human	2.15151304
22	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.08376155
23	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.05390951
24	FOXP3_21729870_ChIP-Seq_TREG_Human	2.03808089
25	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.01697365
26	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.99382345
27	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.91315976
28	ZNF274_21170338_ChIP-Seq_K562_Hela	1.90367408
29	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.81471862
30	MYB_26560356_Chip-Seq_TH2_Human	1.80545885
31	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.72968199
32	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.71838865
33	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.68930279
34	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.64860014
35	GATA3_26560356_Chip-Seq_TH2_Human	1.63214031
36	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.62619040
37	EWS_26573619_Chip-Seq_HEK293_Human	1.61497983
38	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.55984105
39	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.54481231
40	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.44640668
41	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.44022220
42	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.39479041
43	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.38066938
44	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.37596568
45	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.37423001
46	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.34615409
47	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.34219931
48	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.33269571
49	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.29978674
50	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.28672762
51	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.28672762
52	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.28075146
53	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.27962127
54	AR_20517297_ChIP-Seq_VCAP_Human	1.24223499
55	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.24098591
56	IRF1_19129219_ChIP-ChIP_H3396_Human	1.23817425
57	DCP1A_22483619_ChIP-Seq_HELA_Human	1.22076223
58	MYC_18940864_ChIP-ChIP_HL60_Human	1.20690608
59	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.19827520
60	RUNX_20019798_ChIP-Seq_JUKART_Human	1.19202008
61	IGF1R_20145208_ChIP-Seq_DFB_Human	1.17067535
62	SPI1_23547873_ChIP-Seq_NB4_Human	1.16204035
63	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	1.10714503
64	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.09460204
65	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.09343389
66	P300_19829295_ChIP-Seq_ESCs_Human	1.09270472
67	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.08876402
68	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.07866799
69	TP53_22573176_ChIP-Seq_HFKS_Human	1.07688423
70	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.07599942
71	SOX2_19829295_ChIP-Seq_ESCs_Human	1.07330112
72	NANOG_19829295_ChIP-Seq_ESCs_Human	1.07330112
73	TAF15_26573619_Chip-Seq_HEK293_Human	1.05332086
74	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.05200501
75	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.03121547
76	GATA3_27048872_Chip-Seq_THYMUS_Human	1.02989078
77	GABP_19822575_ChIP-Seq_HepG2_Human	1.02715195
78	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.02273843
79	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.00610353
80	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.00009991
81	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.99727920
82	POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.98686410
83	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.98192582
84	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.95901456
85	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	0.94738446
86	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.94355653
87	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.94274814
88	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.94181149
89	NCOR_22424771_ChIP-Seq_293T_Human	0.93693106
90	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.90807142
91	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.89802001
92	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.89057071
93	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.88603260
94	NANOG_20526341_ChIP-Seq_ESCs_Human	0.88014054
95	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.87610840
96	CDX2_22108803_ChIP-Seq_LS180_Human	0.87158611
97	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	0.86796043
98	MYB_26560356_Chip-Seq_TH1_Human	0.86778909
99	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.86629856
100	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.86359985

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005671_abnormal_response_to	4.56418453
2	MP0001835_abnormal_antigen_presentation	3.87774057
3	MP0003806_abnormal_nucleotide_metabolis	3.44761388
4	MP0004147_increased_porphyrin_level	2.76105128
5	MP0003724_increased_susceptibility_to	2.59020986
6	MP0008872_abnormal_physiological_respon	2.53736584
7	MP0009785_altered_susceptibility_to	2.48920803
8	MP0002166_altered_tumor_susceptibility	2.36401128
9	MP0003195_calcinosis	2.22052995
10	MP0001800_abnormal_humoral_immune	2.15716964
11	MP0000685_abnormal_immune_system	2.15449258
12	MP0004145_abnormal_muscle_electrophysio	2.07951634
13	MP0002148_abnormal_hypersensitivity_rea	2.07371815
14	MP0006036_abnormal_mitochondrial_physio	2.06746204
15	MP0005000_abnormal_immune_tolerance	2.03361207
16	MP0001790_abnormal_immune_system	2.01932654
17	MP0005387_immune_system_phenotype	2.01932654
18	MP0003763_abnormal_thymus_physiology	1.90967623
19	MP0002006_tumorigenesis	1.89160329
20	MP0002138_abnormal_hepatobiliary_system	1.88989377
21	MP0008875_abnormal_xenobiotic_pharmacok	1.79120806
22	MP0009333_abnormal_splenocyte_physiolog	1.73602489
23	MP0002723_abnormal_immune_serum	1.73016747
24	MP0003866_abnormal_defecation	1.71951941
25	MP0010155_abnormal_intestine_physiology	1.71715635
26	MP0002452_abnormal_antigen_presenting	1.71697925
27	MP0002102_abnormal_ear_morphology	1.71268621
28	MP0001819_abnormal_immune_cell	1.69568243
29	MP0003646_muscle_fatigue	1.67940038
30	MP0002420_abnormal_adaptive_immunity	1.67013141
31	MP0005025_abnormal_response_to	1.65982185
32	MP0005084_abnormal_gallbladder_morpholo	1.64643177
33	MP0009764_decreased_sensitivity_to	1.62513406
34	MP0003718_maternal_effect	1.62406634
35	MP0000372_irregular_coat_pigmentation	1.61911035
36	MP0005360_urolithiasis	1.59050316
37	MP0001873_stomach_inflammation	1.58490867
38	MP0003693_abnormal_embryo_hatching	1.57794402
39	MP0008877_abnormal_DNA_methylation	1.54519488
40	MP0005464_abnormal_platelet_physiology	1.48601402
41	MP0006035_abnormal_mitochondrial_morpho	1.46222987
42	MP0001529_abnormal_vocalization	1.45759725
43	MP0001853_heart_inflammation	1.43150784
44	MP0005167_abnormal_blood-brain_barrier	1.42422623
45	MP0006072_abnormal_retinal_apoptosis	1.39040199
46	MP0002736_abnormal_nociception_after	1.31392901
47	MP0003186_abnormal_redox_activity	1.30474935
48	MP0002837_dystrophic_cardiac_calcinosis	1.30133435
49	MP0002398_abnormal_bone_marrow	1.29358326
50	MP0003786_premature_aging	1.29263963
51	MP0010094_abnormal_chromosome_stability	1.28043333
52	MP0000716_abnormal_immune_system	1.26860879
53	MP0002277_abnormal_respiratory_mucosa	1.24493121
54	MP0009697_abnormal_copulation	1.24443846
55	MP0002419_abnormal_innate_immunity	1.21232974
56	MP0001845_abnormal_inflammatory_respons	1.21091544
57	MP0005075_abnormal_melanosome_morpholog	1.20964321
58	MP0001905_abnormal_dopamine_level	1.20289234
59	MP0004215_abnormal_myocardial_fiber	1.20228838
60	MP0005645_abnormal_hypothalamus_physiol	1.18833288
61	MP0003638_abnormal_response/metabolism_	1.18729503
62	MP0008058_abnormal_DNA_repair	1.18170037
63	MP0000689_abnormal_spleen_morphology	1.17892115
64	MP0002429_abnormal_blood_cell	1.08412961
65	MP0004957_abnormal_blastocyst_morpholog	1.07585301
66	MP0001968_abnormal_touch/_nociception	1.06482809
67	MP0001485_abnormal_pinna_reflex	1.04805270
68	MP0003011_delayed_dark_adaptation	1.04583399
69	MP0000703_abnormal_thymus_morphology	1.02566866
70	MP0005551_abnormal_eye_electrophysiolog	0.99771026
71	MP0002722_abnormal_immune_system	0.97094082
72	MP0006082_CNS_inflammation	0.94941701
73	MP0005310_abnormal_salivary_gland	0.94723943
74	MP0005636_abnormal_mineral_homeostasis	0.93801083
75	MP0003436_decreased_susceptibility_to	0.88735374
76	MP0000465_gastrointestinal_hemorrhage	0.88341136
77	MP0005085_abnormal_gallbladder_physiolo	0.88314657
78	MP0003448_altered_tumor_morphology	0.84034394
79	MP0001986_abnormal_taste_sensitivity	0.83403097
80	MP0005332_abnormal_amino_acid	0.82683987
81	MP0000015_abnormal_ear_pigmentation	0.81006872
82	MP0009763_increased_sensitivity_to	0.80159706
83	MP0001765_abnormal_ion_homeostasis	0.79389285
84	MP0002933_joint_inflammation	0.78559627
85	MP0003878_abnormal_ear_physiology	0.78029658
86	MP0005377_hearing/vestibular/ear_phenot	0.78029658
87	MP0005410_abnormal_fertilization	0.77039303
88	MP0001919_abnormal_reproductive_system	0.75059607
89	MP0005083_abnormal_biliary_tract	0.74536042
90	MP0002876_abnormal_thyroid_physiology	0.73449000
91	MP0001542_abnormal_bone_strength	0.73186523
92	MP0008789_abnormal_olfactory_epithelium	0.72668884
93	MP0005166_decreased_susceptibility_to	0.72353523
94	MP0003252_abnormal_bile_duct	0.71415408
95	MP0009765_abnormal_xenobiotic_induced	0.69541779
96	MP0002405_respiratory_system_inflammati	0.69150249
97	MP0001188_hyperpigmentation	0.68555426
98	MP0000230_abnormal_systemic_arterial	0.68194856
99	MP0004142_abnormal_muscle_tone	0.66600868
100	MP0000490_abnormal_crypts_of	0.66557049

Predicted human phenotypes

Rank	Gene Set	Z-score
1	3-Methylglutaconic aciduria (HP:0003535)	4.22528970
2	IgG deficiency (HP:0004315)	3.91379413
3	Mitochondrial inheritance (HP:0001427)	3.45146464
4	Increased hepatocellular lipid droplets (HP:0006565)	3.44992533
5	Hepatocellular necrosis (HP:0001404)	3.38778876
6	Methylmalonic acidemia (HP:0002912)	3.34931146
7	Acute necrotizing encephalopathy (HP:0006965)	3.32791754
8	Increased CSF lactate (HP:0002490)	3.30076191
9	Severe combined immunodeficiency (HP:0004430)	3.26426338
10	Hypoproteinemia (HP:0003075)	3.25947427
11	Abnormality of aspartate family amino acid metabolism (HP:0010899)	3.19292604
12	Hepatic necrosis (HP:0002605)	3.17838806
13	Elevated erythrocyte sedimentation rate (HP:0003565)	3.16871297
14	Abnormal mitochondria in muscle tissue (HP:0008316)	3.11884452
15	Lipid accumulation in hepatocytes (HP:0006561)	3.06744636
16	Methylmalonic aciduria (HP:0012120)	2.98970334
17	Stomatitis (HP:0010280)	2.97855774
18	Panhypogammaglobulinemia (HP:0003139)	2.93989287
19	Renal cortical cysts (HP:0000803)	2.93164465
20	Increased intramyocellular lipid droplets (HP:0012240)	2.92663042
21	Acute encephalopathy (HP:0006846)	2.88819274
22	Renal Fanconi syndrome (HP:0001994)	2.78945742
23	Exertional dyspnea (HP:0002875)	2.77043730
24	Abolished electroretinogram (ERG) (HP:0000550)	2.76116190
25	Progressive macrocephaly (HP:0004481)	2.71035165
26	Increased serum lactate (HP:0002151)	2.70826441
27	T lymphocytopenia (HP:0005403)	2.70824071
28	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.68754977
29	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.68754977
30	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.66370232
31	Combined immunodeficiency (HP:0005387)	2.65476212
32	Abnormality of B cell number (HP:0010975)	2.60467326
33	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.58524064
34	Type I transferrin isoform profile (HP:0003642)	2.56634784
35	Abnormality of methionine metabolism (HP:0010901)	2.56301451
36	Abnormality of T cell number (HP:0011839)	2.55234118
37	B lymphocytopenia (HP:0010976)	2.54823905
38	Aplastic anemia (HP:0001915)	2.51380426
39	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.50426237
40	Abnormality of T cells (HP:0002843)	2.46593832
41	Abnormality of the prostate (HP:0008775)	2.42617940
42	Lactic acidosis (HP:0003128)	2.40943952
43	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.38075121
44	Congenital stationary night blindness (HP:0007642)	2.37283269
45	Increased muscle lipid content (HP:0009058)	2.35508914
46	Abnormality of vitamin B metabolism (HP:0004340)	2.31668069
47	Congenital, generalized hypertrichosis (HP:0004540)	2.31566924
48	Abnormality of serum amino acid levels (HP:0003112)	2.29249293
49	Thyroiditis (HP:0100646)	2.29120941
50	Petechiae (HP:0000967)	2.27709979
51	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.21542358
52	Abnormality of alanine metabolism (HP:0010916)	2.21542358
53	Hyperalaninemia (HP:0003348)	2.21542358
54	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.20808707
55	Abnormality of the renal cortex (HP:0011035)	2.20096921
56	Dicarboxylic aciduria (HP:0003215)	2.16631698
57	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.16631698
58	Cerebral edema (HP:0002181)	2.16189440
59	Cerebral palsy (HP:0100021)	2.13868811
60	Progressive inability to walk (HP:0002505)	2.11072244
61	Abnormality of eosinophils (HP:0001879)	2.09423873
62	Reduced antithrombin III activity (HP:0001976)	2.07683426
63	Decreased central vision (HP:0007663)	2.07169772
64	Increased IgM level (HP:0003496)	2.06866688
65	Optic disc pallor (HP:0000543)	2.01910374
66	Abnormality of T cell physiology (HP:0011840)	2.01608743
67	Eosinophilia (HP:0001880)	2.00140057
68	Homocystinuria (HP:0002156)	1.99705341
69	Abnormality of homocysteine metabolism (HP:0010919)	1.99705341
70	Chronic diarrhea (HP:0002028)	1.98889463
71	Prostate neoplasm (HP:0100787)	1.96753608
72	Pancytopenia (HP:0001876)	1.96373838
73	Glycosuria (HP:0003076)	1.94222756
74	Abnormality of urine glucose concentration (HP:0011016)	1.94222756
75	Abnormal glycosylation (HP:0012345)	1.92777394
76	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.92777394
77	Abnormal protein N-linked glycosylation (HP:0012347)	1.92777394
78	Abnormal protein glycosylation (HP:0012346)	1.92777394
79	Respiratory failure (HP:0002878)	1.92545650
80	Abnormal rod and cone electroretinograms (HP:0008323)	1.91598951
81	Generalized aminoaciduria (HP:0002909)	1.88019958
82	Microvesicular hepatic steatosis (HP:0001414)	1.86221235
83	Optic neuritis (HP:0100653)	1.85873844
84	Retrobulbar optic neuritis (HP:0100654)	1.85873844
85	Porencephaly (HP:0002132)	1.85809371
86	Inability to walk (HP:0002540)	1.85541594
87	Chronic mucocutaneous candidiasis (HP:0002728)	1.85302686
88	Recurrent cutaneous fungal infections (HP:0011370)	1.85302686
89	Myositis (HP:0100614)	1.85167111
90	Pancreatic cysts (HP:0001737)	1.84154054
91	Recurrent fungal infections (HP:0002841)	1.83962212
92	Lethargy (HP:0001254)	1.83785647
93	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.81225267
94	Hypoplasia of the fovea (HP:0007750)	1.81225267
95	Megaloblastic anemia (HP:0001889)	1.80943192
96	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	1.80709107
97	Hypoplasia of the thymus (HP:0000778)	1.80304905
98	Encephalitis (HP:0002383)	1.80268790
99	Abnormality of the labia minora (HP:0012880)	1.79020603
100	Colon cancer (HP:0003003)	1.78434399

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MST4	3.78101515
2	VRK2	3.36368332
3	TXK	3.25226545
4	MAP3K12	3.06932002
5	NUAK1	2.99732061
6	TLK1	2.99210648
7	ZAK	2.95210532
8	TESK2	2.47836748
9	MAP4K2	2.36899970
10	BUB1	2.14671666
11	GRK1	2.10700692
12	EIF2AK1	2.07013859
13	MYLK	2.04918139
14	EIF2AK3	1.97382963
15	TSSK6	1.95409350
16	TIE1	1.94434240
17	KDR	1.85305414
18	BMPR2	1.81524455
19	TAOK3	1.80665752
20	TRIM28	1.77140242
21	VRK1	1.72094783
22	DAPK1	1.69797413
23	PINK1	1.66705178
24	TEC	1.64871319
25	ADRBK2	1.58324253
26	NEK1	1.47102143
27	WNK3	1.31840336
28	ITK	1.25106504
29	MAP4K1	1.20875448
30	PLK3	1.20757641
31	IKBKB	1.19972147
32	SYK	1.18098030
33	SRPK1	1.17335042
34	MAPKAPK3	1.14927198
35	TESK1	1.07811366
36	TAF1	1.05807853
37	OXSR1	1.03465365
38	RIPK4	1.03371096
39	EIF2AK2	1.02068152
40	STK16	1.00562693
41	GRK6	1.00550231
42	BCKDK	0.99516601
43	FES	0.95321806
44	LIMK1	0.93773849
45	ZAP70	0.92401089
46	GRK5	0.88559520
47	SCYL2	0.88485525
48	ILK	0.82025195
49	ACVR1B	0.80253973
50	BTK	0.77767937
51	MKNK2	0.77490711
52	WNK4	0.75988719
53	CSNK1G3	0.72655893
54	KIT	0.70016081
55	BMPR1B	0.68349331
56	MKNK1	0.64927236
57	PBK	0.64749072
58	IGF1R	0.63784361
59	LCK	0.63093250
60	DYRK2	0.62981745
61	CCNB1	0.61642691
62	LYN	0.61448614
63	MAPK13	0.59299671
64	RPS6KA5	0.56317566
65	PRKCQ	0.56115885
66	MAP2K6	0.54978864
67	DAPK3	0.54219568
68	PIK3CG	0.53796420
69	ERBB3	0.53714253
70	CDK8	0.53682765
71	CSNK1G1	0.52273831
72	PDK2	0.52263678
73	TTK	0.50846799
74	FRK	0.47169680
75	STK39	0.46773002
76	NME1	0.46708877
77	CSF1R	0.46696595
78	CSNK1A1L	0.45845744
79	CLK1	0.45631308
80	MAPKAPK5	0.45104328
81	INSRR	0.44520212
82	ATR	0.43787932
83	MAP2K2	0.43159273
84	CSK	0.41632636
85	PLK4	0.41280122
86	PTK2B	0.40007627
87	CSNK1G2	0.39723088
88	STK38L	0.38722857
89	MATK	0.35564169
90	IKBKE	0.35441816
91	BRSK2	0.35386204
92	ALK	0.35092611
93	RPS6KA4	0.33837966
94	PAK4	0.31134663
95	OBSCN	0.30818911
96	CSNK2A1	0.30628649
97	TGFBR1	0.29976525
98	AURKB	0.29635263
99	PLK1	0.28041081
100	ABL1	0.27352891

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	4.92794100
2	Asthma_Homo sapiens_hsa05310	3.28244294
3	Allograft rejection_Homo sapiens_hsa05330	2.90866499
4	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.85880597
5	Protein export_Homo sapiens_hsa03060	2.72509357
6	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.69101004
7	Primary immunodeficiency_Homo sapiens_hsa05340	2.65013359
8	Oxidative phosphorylation_Homo sapiens_hsa00190	2.63081175
9	Graft-versus-host disease_Homo sapiens_hsa05332	2.43046123
10	Parkinsons disease_Homo sapiens_hsa05012	2.39729803
11	Antigen processing and presentation_Homo sapiens_hsa04612	2.15103489
12	Type I diabetes mellitus_Homo sapiens_hsa04940	1.98338997
13	RNA polymerase_Homo sapiens_hsa03020	1.79256585
14	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.77847445
15	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.71488043
16	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.66644727
17	Homologous recombination_Homo sapiens_hsa03440	1.63368017
18	Mismatch repair_Homo sapiens_hsa03430	1.63345030
19	DNA replication_Homo sapiens_hsa03030	1.61091295
20	Fatty acid elongation_Homo sapiens_hsa00062	1.56361458
21	Sulfur metabolism_Homo sapiens_hsa00920	1.50985403
22	One carbon pool by folate_Homo sapiens_hsa00670	1.38398268
23	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.36944071
24	Viral myocarditis_Homo sapiens_hsa05416	1.36123480
25	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.33935988
26	Propanoate metabolism_Homo sapiens_hsa00640	1.31448572
27	Huntingtons disease_Homo sapiens_hsa05016	1.30649039
28	RNA degradation_Homo sapiens_hsa03018	1.30558000
29	Non-homologous end-joining_Homo sapiens_hsa03450	1.26688054
30	Rheumatoid arthritis_Homo sapiens_hsa05323	1.24491610
31	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.24332148
32	Phototransduction_Homo sapiens_hsa04744	1.24295153
33	Alzheimers disease_Homo sapiens_hsa05010	1.23926509
34	Basal transcription factors_Homo sapiens_hsa03022	1.23462020
35	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	1.11710289
36	Tryptophan metabolism_Homo sapiens_hsa00380	1.10926610
37	Nucleotide excision repair_Homo sapiens_hsa03420	1.05845214
38	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.98127118
39	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.95936611
40	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.95612792
41	Purine metabolism_Homo sapiens_hsa00230	0.92502452
42	Fanconi anemia pathway_Homo sapiens_hsa03460	0.92097866
43	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.90764115
44	Regulation of autophagy_Homo sapiens_hsa04140	0.89870523
45	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.88457632
46	Pyrimidine metabolism_Homo sapiens_hsa00240	0.85230270
47	Chemical carcinogenesis_Homo sapiens_hsa05204	0.83427359
48	Spliceosome_Homo sapiens_hsa03040	0.79737558
49	Base excision repair_Homo sapiens_hsa03410	0.77691010
50	Ribosome_Homo sapiens_hsa03010	0.76776865
51	Linoleic acid metabolism_Homo sapiens_hsa00591	0.76444517
52	Glutathione metabolism_Homo sapiens_hsa00480	0.75470445
53	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.75304481
54	Peroxisome_Homo sapiens_hsa04146	0.75242198
55	RNA transport_Homo sapiens_hsa03013	0.74559866
56	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.74406081
57	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.74319181
58	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.73567981
59	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.73119394
60	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.71540532
61	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.70273568
62	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.69878794
63	Cardiac muscle contraction_Homo sapiens_hsa04260	0.69790674
64	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.69736659
65	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.68201457
66	Steroid biosynthesis_Homo sapiens_hsa00100	0.67511287
67	Collecting duct acid secretion_Homo sapiens_hsa04966	0.67359334
68	Retinol metabolism_Homo sapiens_hsa00830	0.67267165
69	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.66700514
70	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.64251275
71	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.63274502
72	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.62469197
73	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.62029335
74	Caffeine metabolism_Homo sapiens_hsa00232	0.61328139
75	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.60643418
76	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.57846822
77	Shigellosis_Homo sapiens_hsa05131	0.57684760
78	Fat digestion and absorption_Homo sapiens_hsa04975	0.57587445
79	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.56910715
80	Butanoate metabolism_Homo sapiens_hsa00650	0.56423448
81	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.55684137
82	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.55202840
83	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.50606287
84	Nitrogen metabolism_Homo sapiens_hsa00910	0.50589556
85	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.50578943
86	Renin-angiotensin system_Homo sapiens_hsa04614	0.48926429
87	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.44228623
88	Metabolic pathways_Homo sapiens_hsa01100	0.43076288
89	beta-Alanine metabolism_Homo sapiens_hsa00410	0.42966055
90	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.41874711
91	Pyruvate metabolism_Homo sapiens_hsa00620	0.41027165
92	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.38319420
93	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.36467606
94	Leishmaniasis_Homo sapiens_hsa05140	0.36346351
95	Olfactory transduction_Homo sapiens_hsa04740	0.34873617
96	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.34786454
97	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.32063618
98	Legionellosis_Homo sapiens_hsa05134	0.31045219
99	Herpes simplex infection_Homo sapiens_hsa05168	0.30806154
100	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.28018127

ACTG1P19

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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