ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	proteasome assembly (GO:0043248)	5.34903363
2	DNA deamination (GO:0045006)	5.26502668
3	protein deneddylation (GO:0000338)	4.62379204
4	cullin deneddylation (GO:0010388)	4.38800707
5	rRNA modification (GO:0000154)	3.92661129
6	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.90796795
7	regulation of cellular amino acid metabolic process (GO:0006521)	3.83269350
8	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.71740761
9	rRNA methylation (GO:0031167)	3.62889148
10	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	3.61396050
11	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.61174529
12	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	3.59408219
13	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.59363327
14	ATP synthesis coupled proton transport (GO:0015986)	3.59363327
15	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.58709627
16	ribosome assembly (GO:0042255)	3.57293328
17	regulation of mitotic spindle checkpoint (GO:1903504)	3.55791538
18	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	3.55791538
19	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	3.55625152
20	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	3.55625152
21	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	3.55625152
22	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	3.54340273
23	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.53832720
24	protein neddylation (GO:0045116)	3.52238516
25	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	3.50969103
26	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	3.50969103
27	negative regulation of ligase activity (GO:0051352)	3.45572473
28	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	3.45572473
29	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.42534992
30	NADH dehydrogenase complex assembly (GO:0010257)	3.42534992
31	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.42534992
32	signal transduction involved in cell cycle checkpoint (GO:0072395)	3.40806655
33	signal transduction involved in DNA integrity checkpoint (GO:0072401)	3.39189603
34	signal transduction involved in DNA damage checkpoint (GO:0072422)	3.39189603
35	chaperone-mediated protein transport (GO:0072321)	3.37815885
36	mannosylation (GO:0097502)	3.37065055
37	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	3.33524639
38	respiratory chain complex IV assembly (GO:0008535)	3.33432606
39	platelet dense granule organization (GO:0060155)	3.25121476
40	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.23901109
41	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	3.19646263
42	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	3.19646263
43	isotype switching (GO:0045190)	3.19646263
44	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	3.17393386
45	protein complex biogenesis (GO:0070271)	3.15991681
46	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.13655289
47	termination of RNA polymerase III transcription (GO:0006386)	3.13655289
48	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.12205465
49	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.12205465
50	cytidine metabolic process (GO:0046087)	3.09843813
51	cytidine catabolic process (GO:0006216)	3.09843813
52	cytidine deamination (GO:0009972)	3.09843813
53	positive regulation of ligase activity (GO:0051351)	3.06669206
54	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.05972272
55	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.00539468
56	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:	2.97831198
57	metallo-sulfur cluster assembly (GO:0031163)	2.97382289
58	iron-sulfur cluster assembly (GO:0016226)	2.97382289
59	DNA double-strand break processing (GO:0000729)	2.96188751
60	mitochondrial respiratory chain complex assembly (GO:0033108)	2.95274304
61	water-soluble vitamin biosynthetic process (GO:0042364)	2.94176894
62	preassembly of GPI anchor in ER membrane (GO:0016254)	2.89639220
63	protein K6-linked ubiquitination (GO:0085020)	2.88120768
64	chaperone mediated protein folding requiring cofactor (GO:0051085)	2.88067786
65	GMP metabolic process (GO:0046037)	2.88002233
66	tRNA processing (GO:0008033)	2.85204540
67	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.84640385
68	establishment of integrated proviral latency (GO:0075713)	2.84592290
69	tRNA metabolic process (GO:0006399)	2.84229084
70	antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)	2.82099514
71	tRNA aminoacylation (GO:0043039)	2.79891317
72	amino acid activation (GO:0043038)	2.79891317
73	GPI anchor biosynthetic process (GO:0006506)	2.77224214
74	GPI anchor metabolic process (GO:0006505)	2.76963626
75	tRNA aminoacylation for protein translation (GO:0006418)	2.75601625
76	L-methionine salvage (GO:0071267)	2.71661093
77	L-methionine biosynthetic process (GO:0071265)	2.71661093
78	amino acid salvage (GO:0043102)	2.71661093
79	aldehyde catabolic process (GO:0046185)	2.70899202
80	mitochondrial RNA metabolic process (GO:0000959)	2.68961620
81	DNA ligation (GO:0006266)	2.68300343
82	DNA damage response, signal transduction by p53 class mediator (GO:0030330)	2.68170313
83	establishment of viral latency (GO:0019043)	2.67932528
84	regulation of cellular amine metabolic process (GO:0033238)	2.67637063
85	branched-chain amino acid catabolic process (GO:0009083)	2.67494663
86	C-terminal protein lipidation (GO:0006501)	2.65905393
87	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.65302167
88	histone mRNA metabolic process (GO:0008334)	2.65196660
89	regulation of ubiquitin-protein transferase activity (GO:0051438)	2.63712712
90	positive regulation of cell cycle arrest (GO:0071158)	2.63245858
91	C-terminal protein amino acid modification (GO:0018410)	2.62937092
92	regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)	2.62689519
93	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.62542017
94	spliceosomal snRNP assembly (GO:0000387)	2.62496930
95	DNA damage response, detection of DNA damage (GO:0042769)	2.61410720
96	protein-cofactor linkage (GO:0018065)	2.61395011
97	regulation of chronic inflammatory response (GO:0002676)	2.61394085
98	termination of RNA polymerase I transcription (GO:0006363)	2.61155892
99	de novo protein folding (GO:0006458)	2.60485882
100	purine nucleobase biosynthetic process (GO:0009113)	2.59726636

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	5.32161893
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.44358118
3	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.89926219
4	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.55873316
5	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.47554582
6	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.13867949
7	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.08019860
8	VDR_23849224_ChIP-Seq_CD4+_Human	2.99007268
9	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.98204776
10	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.94392205
11	ELK1_19687146_ChIP-ChIP_HELA_Human	2.91962939
12	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.80998691
13	ZNF274_21170338_ChIP-Seq_K562_Hela	2.57115635
14	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.54221451
15	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.44018122
16	FOXP3_21729870_ChIP-Seq_TREG_Human	2.38374769
17	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.35944878
18	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.30840187
19	VDR_22108803_ChIP-Seq_LS180_Human	2.28897043
20	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.28609992
21	DCP1A_22483619_ChIP-Seq_HELA_Human	2.19576688
22	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.15789995
23	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.15525407
24	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.12824541
25	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	2.04015835
26	MYC_18940864_ChIP-ChIP_HL60_Human	1.96748498
27	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.86150666
28	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.85959799
29	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.83467786
30	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.81559736
31	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.78815704
32	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.76909294
33	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.75265193
34	GABP_19822575_ChIP-Seq_HepG2_Human	1.68307046
35	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.66455651
36	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.64071033
37	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.63331109
38	EWS_26573619_Chip-Seq_HEK293_Human	1.59346960
39	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.54692110
40	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.53145293
41	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.51993872
42	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.51001478
43	TTF2_22483619_ChIP-Seq_HELA_Human	1.49855968
44	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.48394337
45	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.45885997
46	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.39343073
47	IGF1R_20145208_ChIP-Seq_DFB_Human	1.38050608
48	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.34946631
49	CIITA_25753668_ChIP-Seq_RAJI_Human	1.34520920
50	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.34251825
51	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.33793546
52	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.25250494
53	E2F7_22180533_ChIP-Seq_HELA_Human	1.24445667
54	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.23448313
55	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.23322228
56	GATA3_26560356_Chip-Seq_TH2_Human	1.18212907
57	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.16278600
58	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.14938016
59	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.14736651
60	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.13574253
61	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.13502351
62	FUS_26573619_Chip-Seq_HEK293_Human	1.12747305
63	IRF1_19129219_ChIP-ChIP_H3396_Human	1.11273080
64	TP53_22573176_ChIP-Seq_HFKS_Human	1.11082834
65	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.10468510
66	SOX2_19829295_ChIP-Seq_ESCs_Human	1.10362689
67	NANOG_19829295_ChIP-Seq_ESCs_Human	1.10362689
68	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.09207378
69	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.07639634
70	AR_20517297_ChIP-Seq_VCAP_Human	1.07412720
71	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.07308360
72	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.07308360
73	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.06815368
74	XRN2_22483619_ChIP-Seq_HELA_Human	1.06310131
75	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	1.06047650
76	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.05933641
77	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.05775200
78	P300_19829295_ChIP-Seq_ESCs_Human	1.01686011
79	SPI1_23547873_ChIP-Seq_NB4_Human	1.00380165
80	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	1.00321576
81	TAF15_26573619_Chip-Seq_HEK293_Human	0.98449858
82	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	0.98243856
83	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.96917073
84	MYB_26560356_Chip-Seq_TH2_Human	0.94557418
85	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.94441120
86	KDM5A_27292631_Chip-Seq_BREAST_Human	0.94058205
87	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.90194870
88	SALL4_22934838_ChIP-ChIP_CD34+_Human	0.89310528
89	ZFP57_27257070_Chip-Seq_ESCs_Mouse	0.88830785
90	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	0.88762717
91	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.86859320
92	SALL1_21062744_ChIP-ChIP_HESCs_Human	0.85975382
93	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.84956502
94	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.84298416
95	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.83006663
96	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	0.82731374
97	CBP_20019798_ChIP-Seq_JUKART_Human	0.82390279
98	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.82390279
99	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.82146851
100	MYCN_18555785_ChIP-Seq_MESCs_Mouse	0.80811578

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0001835_abnormal_antigen_presentation	3.33078866
2	MP0008058_abnormal_DNA_repair	3.28983787
3	MP0000372_irregular_coat_pigmentation	3.27253660
4	MP0003806_abnormal_nucleotide_metabolis	3.17642977
5	MP0003786_premature_aging	2.83813325
6	MP0002102_abnormal_ear_morphology	2.83319736
7	MP0003195_calcinosis	2.71363999
8	MP0010094_abnormal_chromosome_stability	2.68908260
9	MP0005671_abnormal_response_to	2.63152665
10	MP0006072_abnormal_retinal_apoptosis	2.51203573
11	MP0006036_abnormal_mitochondrial_physio	2.46064252
12	MP0005075_abnormal_melanosome_morpholog	2.38264576
13	MP0008877_abnormal_DNA_methylation	2.27190976
14	MP0004147_increased_porphyrin_level	2.22861279
15	MP0001529_abnormal_vocalization	2.19406578
16	MP0008007_abnormal_cellular_replicative	2.15017382
17	MP0003186_abnormal_redox_activity	2.14539687
18	MP0009785_altered_susceptibility_to	2.05414855
19	MP0003111_abnormal_nucleus_morphology	2.00219953
20	MP0008995_early_reproductive_senescence	1.94314462
21	MP0005645_abnormal_hypothalamus_physiol	1.80475718
22	MP0003718_maternal_effect	1.80010225
23	MP0005253_abnormal_eye_physiology	1.75063347
24	MP0009764_decreased_sensitivity_to	1.69263346
25	MP0002148_abnormal_hypersensitivity_rea	1.68292397
26	MP0008875_abnormal_xenobiotic_pharmacok	1.67701606
27	MP0003693_abnormal_embryo_hatching	1.64714064
28	MP0004957_abnormal_blastocyst_morpholog	1.64339843
29	MP0001873_stomach_inflammation	1.55176874
30	MP0005551_abnormal_eye_electrophysiolog	1.54789518
31	MP0003950_abnormal_plasma_membrane	1.50013473
32	MP0002396_abnormal_hematopoietic_system	1.47624092
33	MP0000358_abnormal_cell_content/	1.46752303
34	MP0005000_abnormal_immune_tolerance	1.41935474
35	MP0001800_abnormal_humoral_immune	1.41601249
36	MP0006035_abnormal_mitochondrial_morpho	1.40579386
37	MP0005084_abnormal_gallbladder_morpholo	1.40264659
38	MP0008872_abnormal_physiological_respon	1.38432326
39	MP0002166_altered_tumor_susceptibility	1.36582320
40	MP0009697_abnormal_copulation	1.36012656
41	MP0005408_hypopigmentation	1.33006312
42	MP0000685_abnormal_immune_system	1.32165461
43	MP0003077_abnormal_cell_cycle	1.31610834
44	MP0002006_tumorigenesis	1.27496310
45	MP0002723_abnormal_immune_serum	1.21172376
46	MP0002751_abnormal_autonomic_nervous	1.17390572
47	MP0001790_abnormal_immune_system	1.16985926
48	MP0005387_immune_system_phenotype	1.16985926
49	MP0002452_abnormal_antigen_presenting	1.14867225
50	MP0009333_abnormal_splenocyte_physiolog	1.14824629
51	MP0003724_increased_susceptibility_to	1.13533433
52	MP0004145_abnormal_muscle_electrophysio	1.11728775
53	MP0001542_abnormal_bone_strength	1.09626411
54	MP0003646_muscle_fatigue	1.08518461
55	MP0003866_abnormal_defecation	1.07940631
56	MP0002234_abnormal_pharynx_morphology	1.07781802
57	MP0003436_decreased_susceptibility_to	1.07367254
58	MP0001819_abnormal_immune_cell	1.04339339
59	MP0002420_abnormal_adaptive_immunity	1.01722568
60	MP0002938_white_spotting	1.00815615
61	MP0002095_abnormal_skin_pigmentation	0.99619523
62	MP0001984_abnormal_olfaction	0.99072629
63	MP0005171_absent_coat_pigmentation	0.98332709
64	MP0002019_abnormal_tumor_incidence	0.97510026
65	MP0005165_increased_susceptibility_to	0.97272162
66	MP0001986_abnormal_taste_sensitivity	0.97266650
67	MP0008932_abnormal_embryonic_tissue	0.96586531
68	MP0010386_abnormal_urinary_bladder	0.96223042
69	MP0001243_abnormal_dermal_layer	0.93271970
70	MP0005332_abnormal_amino_acid	0.92697386
71	MP0001929_abnormal_gametogenesis	0.91014767
72	MP0005410_abnormal_fertilization	0.90100341
73	MP0001919_abnormal_reproductive_system	0.88128754
74	MP0002398_abnormal_bone_marrow	0.86891215
75	MP0001853_heart_inflammation	0.86653931
76	MP0002090_abnormal_vision	0.86347641
77	MP0000689_abnormal_spleen_morphology	0.86105626
78	MP0004215_abnormal_myocardial_fiber	0.86095138
79	MP0002736_abnormal_nociception_after	0.84088273
80	MP0000465_gastrointestinal_hemorrhage	0.81963136
81	MP0008873_increased_physiological_sensi	0.81684312
82	MP0004142_abnormal_muscle_tone	0.80914343
83	MP0010155_abnormal_intestine_physiology	0.79144819
84	MP0005389_reproductive_system_phenotype	0.78760246
85	MP0005360_urolithiasis	0.78542151
86	MP0002722_abnormal_immune_system	0.77982497
87	MP0009763_increased_sensitivity_to	0.77919778
88	MP0005025_abnormal_response_to	0.76078820
89	MP0001845_abnormal_inflammatory_respons	0.76021501
90	MP0001905_abnormal_dopamine_level	0.75643334
91	MP0000716_abnormal_immune_system	0.75505525
92	MP0003011_delayed_dark_adaptation	0.75404811
93	MP0001764_abnormal_homeostasis	0.73551727
94	MP0005174_abnormal_tail_pigmentation	0.72426701
95	MP0002429_abnormal_blood_cell	0.72423175
96	MP0002210_abnormal_sex_determination	0.71844588
97	MP0002419_abnormal_innate_immunity	0.70958250
98	MP0003880_abnormal_central_pattern	0.70891583
99	MP0005395_other_phenotype	0.69661454
100	MP0002254_reproductive_system_inflammat	0.67928529

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	4.45024109
2	Hepatocellular necrosis (HP:0001404)	4.17398483
3	Mitochondrial inheritance (HP:0001427)	4.16081510
4	Increased CSF lactate (HP:0002490)	4.06996045
5	Abnormal mitochondria in muscle tissue (HP:0008316)	3.98492577
6	Acute encephalopathy (HP:0006846)	3.97837910
7	Progressive macrocephaly (HP:0004481)	3.71821809
8	Hepatic necrosis (HP:0002605)	3.61986672
9	Type I transferrin isoform profile (HP:0003642)	3.43087777
10	Increased hepatocellular lipid droplets (HP:0006565)	3.37055721
11	Increased serum lactate (HP:0002151)	3.35164913
12	Lipid accumulation in hepatocytes (HP:0006561)	3.22007650
13	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	3.19513310
14	Abnormal protein N-linked glycosylation (HP:0012347)	3.19513310
15	Abnormal protein glycosylation (HP:0012346)	3.19513310
16	Abnormal glycosylation (HP:0012345)	3.19513310
17	Cerebral edema (HP:0002181)	3.16106929
18	Methylmalonic acidemia (HP:0002912)	3.10971995
19	Congenital stationary night blindness (HP:0007642)	2.99763206
20	IgG deficiency (HP:0004315)	2.96972259
21	Renal Fanconi syndrome (HP:0001994)	2.94952350
22	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.88113063
23	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.88113063
24	Type 2 muscle fiber atrophy (HP:0003554)	2.87593805
25	Exertional dyspnea (HP:0002875)	2.83402629
26	Lactic acidosis (HP:0003128)	2.78845052
27	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.76304824
28	Hypoproteinemia (HP:0003075)	2.75583832
29	Optic disc pallor (HP:0000543)	2.62852033
30	Abnormality of the prostate (HP:0008775)	2.62583544
31	Methylmalonic aciduria (HP:0012120)	2.60672973
32	Increased intramyocellular lipid droplets (HP:0012240)	2.57438605
33	Attenuation of retinal blood vessels (HP:0007843)	2.53437679
34	Molar tooth sign on MRI (HP:0002419)	2.53312006
35	Abnormality of midbrain morphology (HP:0002418)	2.53312006
36	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.51774730
37	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.48683853
38	Hypothermia (HP:0002045)	2.41713798
39	Decreased central vision (HP:0007663)	2.40657862
40	Muscle fiber atrophy (HP:0100295)	2.40566355
41	3-Methylglutaconic aciduria (HP:0003535)	2.39828759
42	Pancreatic cysts (HP:0001737)	2.35891742
43	Posterior subcapsular cataract (HP:0007787)	2.32965512
44	Exercise intolerance (HP:0003546)	2.32738433
45	Abnormality of methionine metabolism (HP:0010901)	2.29974748
46	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.29874196
47	Abolished electroretinogram (ERG) (HP:0000550)	2.29847113
48	Panhypogammaglobulinemia (HP:0003139)	2.29324992
49	Microvesicular hepatic steatosis (HP:0001414)	2.26654965
50	Meckel diverticulum (HP:0002245)	2.24909402
51	Abnormality of the ileum (HP:0001549)	2.22583518
52	Type II lissencephaly (HP:0007260)	2.21450811
53	Respiratory failure (HP:0002878)	2.18722542
54	Lethargy (HP:0001254)	2.18046425
55	Dyschromatopsia (HP:0007641)	2.17583386
56	Abnormality of glycolysis (HP:0004366)	2.13322642
57	Short tibia (HP:0005736)	2.11475291
58	Congenital, generalized hypertrichosis (HP:0004540)	2.11025455
59	Increased serum pyruvate (HP:0003542)	2.10381063
60	Increased muscle lipid content (HP:0009058)	2.07944225
61	CNS demyelination (HP:0007305)	2.07057526
62	Severe combined immunodeficiency (HP:0004430)	2.06893892
63	Reduced antithrombin III activity (HP:0001976)	2.06350418
64	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.02705255
65	Nephronophthisis (HP:0000090)	2.00137373
66	Leukodystrophy (HP:0002415)	1.97798719
67	Abnormality of chromosome stability (HP:0003220)	1.95758932
68	Progressive microcephaly (HP:0000253)	1.94125543
69	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.92285368
70	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.91860890
71	Recurrent cutaneous fungal infections (HP:0011370)	1.91290820
72	Chronic mucocutaneous candidiasis (HP:0002728)	1.91290820
73	Sensory axonal neuropathy (HP:0003390)	1.90578633
74	Degeneration of anterior horn cells (HP:0002398)	1.87297086
75	Abnormality of the anterior horn cell (HP:0006802)	1.87297086
76	Constricted visual fields (HP:0001133)	1.83643736
77	B lymphocytopenia (HP:0010976)	1.82674005
78	Abnormality of serum amino acid levels (HP:0003112)	1.82484060
79	Sloping forehead (HP:0000340)	1.82244594
80	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.81033699
81	Abnormality of placental membranes (HP:0011409)	1.80829488
82	Amniotic constriction ring (HP:0009775)	1.80829488
83	Abnormality of T cell physiology (HP:0011840)	1.80044708
84	Stomatitis (HP:0010280)	1.79710852
85	Abnormality of the preputium (HP:0100587)	1.79328238
86	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.78729048
87	Hypoplasia of the fovea (HP:0007750)	1.78729048
88	Respiratory difficulties (HP:0002880)	1.78129757
89	Emotional lability (HP:0000712)	1.77882089
90	Aplasia/hypoplasia of the uterus (HP:0008684)	1.77536093
91	Cerebral hypomyelination (HP:0006808)	1.77223144
92	True hermaphroditism (HP:0010459)	1.77052857
93	Abnormality of B cell number (HP:0010975)	1.76831021
94	Duodenal stenosis (HP:0100867)	1.76719878
95	Small intestinal stenosis (HP:0012848)	1.76719878
96	Elevated erythrocyte sedimentation rate (HP:0003565)	1.76424297
97	Neonatal respiratory distress (HP:0002643)	1.75474961
98	Retinal dysplasia (HP:0007973)	1.74993600
99	Lissencephaly (HP:0001339)	1.74768999
100	Opisthotonus (HP:0002179)	1.74415972

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TRIM28	3.84254690
2	MAP4K2	3.43977620
3	NUAK1	3.21010771
4	MST4	3.06416332
5	VRK2	3.00071164
6	BUB1	2.91282484
7	TSSK6	2.82772581
8	ZAK	2.62916553
9	TAOK3	2.54120487
10	EIF2AK3	2.38474485
11	BCKDK	2.30489922
12	MAP3K12	2.15478257
13	NEK1	2.15463362
14	SRPK1	2.10025083
15	MYLK	1.90109570
16	TLK1	1.82778164
17	TXK	1.79522410
18	PDK2	1.65226004
19	BMPR2	1.62401480
20	TIE1	1.60690369
21	EIF2AK1	1.59484804
22	ADRBK2	1.47345288
23	DAPK1	1.46380521
24	GRK6	1.43347735
25	GRK1	1.40647526
26	VRK1	1.40526462
27	PLK3	1.40236880
28	BMPR1B	1.39008577
29	WNK3	1.34530951
30	PBK	1.29573992
31	TAF1	1.26420240
32	SIK3	1.23546525
33	EIF2AK2	1.17044380
34	MUSK	1.13746776
35	KIT	1.12045582
36	MKNK1	1.11508474
37	OXSR1	1.11207049
38	FRK	1.09293944
39	CSNK1G3	1.06744300
40	CDK19	0.99298201
41	CDK8	0.96758189
42	TEC	0.92813755
43	CSNK1A1L	0.89593045
44	KDR	0.89150466
45	IKBKB	0.87336661
46	MKNK2	0.82382805
47	NME1	0.81874086
48	ATR	0.80403935
49	CSNK1G2	0.80290989
50	LIMK1	0.79961304
51	TGFBR1	0.78706325
52	CSNK1G1	0.78683260
53	ERBB3	0.77950582
54	BCR	0.76916388
55	FLT3	0.74526339
56	TTK	0.72245281
57	CDC7	0.71689904
58	MAPKAPK3	0.67291064
59	GRK5	0.66720423
60	PIM2	0.66411731
61	AURKB	0.64812096
62	TESK1	0.64805585
63	PIK3CG	0.63688796
64	STK38L	0.63532018
65	MARK3	0.62621190
66	PLK1	0.62169860
67	DYRK2	0.61362993
68	WNK4	0.55439380
69	INSRR	0.55390858
70	MAPK13	0.54233150
71	ILK	0.52507377
72	CLK1	0.51425199
73	CCNB1	0.51217524
74	TESK2	0.51212747
75	STK16	0.51120477
76	ADRBK1	0.49298853
77	STK3	0.48652183
78	CHEK2	0.48626695
79	CSF1R	0.47965938
80	TBK1	0.47908183
81	DAPK3	0.46089542
82	NME2	0.45035449
83	JAK3	0.44834220
84	RPS6KA4	0.44142547
85	ITK	0.43967624
86	PLK2	0.43306203
87	RPS6KA5	0.43287468
88	MAP4K1	0.41432887
89	GRK7	0.40980640
90	MAPKAPK5	0.40031954
91	PASK	0.39032196
92	CSNK2A1	0.38758758
93	PLK4	0.37550388
94	ATM	0.36396280
95	CSNK2A2	0.34542324
96	PAK3	0.34232566
97	TGFBR2	0.34079650
98	LYN	0.33609279
99	SYK	0.32460717
100	STK39	0.31458462

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	4.30293080
2	Asthma_Homo sapiens_hsa05310	3.64440804
3	Protein export_Homo sapiens_hsa03060	3.04620732
4	Allograft rejection_Homo sapiens_hsa05330	3.01824623
5	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.82991374
6	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.75339797
7	RNA polymerase_Homo sapiens_hsa03020	2.57403357
8	Graft-versus-host disease_Homo sapiens_hsa05332	2.52761202
9	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.43557921
10	Type I diabetes mellitus_Homo sapiens_hsa04940	2.40164509
11	Oxidative phosphorylation_Homo sapiens_hsa00190	2.33452334
12	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.13159785
13	Parkinsons disease_Homo sapiens_hsa05012	2.02702402
14	Non-homologous end-joining_Homo sapiens_hsa03450	2.00453971
15	One carbon pool by folate_Homo sapiens_hsa00670	1.92048448
16	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.87593039
17	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.87397709
18	Propanoate metabolism_Homo sapiens_hsa00640	1.75438889
19	Homologous recombination_Homo sapiens_hsa03440	1.67334860
20	Viral myocarditis_Homo sapiens_hsa05416	1.62847552
21	Rheumatoid arthritis_Homo sapiens_hsa05323	1.59987709
22	RNA degradation_Homo sapiens_hsa03018	1.57399866
23	Fanconi anemia pathway_Homo sapiens_hsa03460	1.55863211
24	Basal transcription factors_Homo sapiens_hsa03022	1.44520375
25	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.43721841
26	RNA transport_Homo sapiens_hsa03013	1.43386388
27	Antigen processing and presentation_Homo sapiens_hsa04612	1.41069140
28	Mismatch repair_Homo sapiens_hsa03430	1.35102406
29	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.34967337
30	Huntingtons disease_Homo sapiens_hsa05016	1.34051665
31	Pyrimidine metabolism_Homo sapiens_hsa00240	1.27327978
32	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.23463345
33	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.22245700
34	DNA replication_Homo sapiens_hsa03030	1.22138899
35	Spliceosome_Homo sapiens_hsa03040	1.21829589
36	Primary immunodeficiency_Homo sapiens_hsa05340	1.21433154
37	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.20785453
38	Fatty acid elongation_Homo sapiens_hsa00062	1.19450250
39	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.13317494
40	Ribosome_Homo sapiens_hsa03010	1.11995899
41	Phototransduction_Homo sapiens_hsa04744	1.09846098
42	Purine metabolism_Homo sapiens_hsa00230	1.09088573
43	Nucleotide excision repair_Homo sapiens_hsa03420	1.07897971
44	Alzheimers disease_Homo sapiens_hsa05010	1.05235568
45	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.00859525
46	Base excision repair_Homo sapiens_hsa03410	0.98019643
47	Sulfur metabolism_Homo sapiens_hsa00920	0.95236340
48	Steroid biosynthesis_Homo sapiens_hsa00100	0.91151514
49	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.90780377
50	Regulation of autophagy_Homo sapiens_hsa04140	0.88790433
51	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.87937675
52	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.86822292
53	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.84196301
54	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.82503572
55	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.80952913
56	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.74342861
57	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.73287195
58	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.70653289
59	Glutathione metabolism_Homo sapiens_hsa00480	0.69725088
60	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.66055401
61	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.65330863
62	Herpes simplex infection_Homo sapiens_hsa05168	0.65100624
63	Butanoate metabolism_Homo sapiens_hsa00650	0.64574048
64	Leishmaniasis_Homo sapiens_hsa05140	0.64180217
65	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.62113252
66	Peroxisome_Homo sapiens_hsa04146	0.59885116
67	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.58338103
68	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.57644796
69	Nitrogen metabolism_Homo sapiens_hsa00910	0.57324841
70	Metabolic pathways_Homo sapiens_hsa01100	0.57285791
71	Collecting duct acid secretion_Homo sapiens_hsa04966	0.55792011
72	Carbon metabolism_Homo sapiens_hsa01200	0.55562535
73	Sulfur relay system_Homo sapiens_hsa04122	0.55258905
74	Pyruvate metabolism_Homo sapiens_hsa00620	0.54299895
75	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.53376191
76	Selenocompound metabolism_Homo sapiens_hsa00450	0.53185733
77	Tryptophan metabolism_Homo sapiens_hsa00380	0.51949581
78	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.51759149
79	Caffeine metabolism_Homo sapiens_hsa00232	0.48910161
80	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.45123821
81	Folate biosynthesis_Homo sapiens_hsa00790	0.43942634
82	Legionellosis_Homo sapiens_hsa05134	0.43072623
83	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.43045142
84	Cardiac muscle contraction_Homo sapiens_hsa04260	0.41903084
85	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.41171063
86	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.40139168
87	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.38864782
88	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.36607818
89	Cell cycle_Homo sapiens_hsa04110	0.35277556
90	Linoleic acid metabolism_Homo sapiens_hsa00591	0.33836120
91	Chemical carcinogenesis_Homo sapiens_hsa05204	0.33541854
92	p53 signaling pathway_Homo sapiens_hsa04115	0.33234660
93	Phagosome_Homo sapiens_hsa04145	0.32583015
94	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.31031361
95	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.30341654
96	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.29783608
97	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.26129223
98	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.24067131
99	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.23285084
100	Olfactory transduction_Homo sapiens_hsa04740	0.19963330

ACTG1P20

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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