ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	response to gravity (GO:0009629)	8.23362032
2	DNA deamination (GO:0045006)	5.09282422
3	protein deneddylation (GO:0000338)	4.88752555
4	cullin deneddylation (GO:0010388)	4.86596688
5	regulation of skeletal muscle contraction (GO:0014819)	4.43095713
6	proteasome assembly (GO:0043248)	4.37158198
7	regulation of cellular amino acid metabolic process (GO:0006521)	4.14398162
8	actin-myosin filament sliding (GO:0033275)	4.12421091
9	muscle filament sliding (GO:0030049)	4.12421091
10	skeletal muscle adaptation (GO:0043501)	4.00197325
11	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.84644781
12	striated muscle atrophy (GO:0014891)	3.78173285
13	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	3.76907373
14	Arp2/3 complex-mediated actin nucleation (GO:0034314)	3.72075849
15	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	3.70611108
16	adenosine metabolic process (GO:0046085)	3.69449620
17	skeletal muscle tissue regeneration (GO:0043403)	3.67741250
18	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	3.64367190
19	cytidine deamination (GO:0009972)	3.64346539
20	cytidine metabolic process (GO:0046087)	3.64346539
21	cytidine catabolic process (GO:0006216)	3.64346539
22	protein K6-linked ubiquitination (GO:0085020)	3.62733574
23	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	3.61824756
24	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.58296614
25	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.58296614
26	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	3.57964515
27	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	3.57964515
28	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	3.57964515
29	positive regulation of mitochondrial calcium ion concentration (GO:0051561)	3.56346638
30	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	3.55887114
31	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	3.55887114
32	positive regulation of T cell mediated cytotoxicity (GO:0001916)	3.55107849
33	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:	3.53801987
34	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.53801594
35	negative regulation of muscle hypertrophy (GO:0014741)	3.51867364
36	protein neddylation (GO:0045116)	3.50910625
37	negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)	3.46841225
38	platelet dense granule organization (GO:0060155)	3.45026027
39	signal transduction involved in DNA integrity checkpoint (GO:0072401)	3.38762645
40	signal transduction involved in DNA damage checkpoint (GO:0072422)	3.38762645
41	regulation of T cell mediated cytotoxicity (GO:0001914)	3.38077125
42	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	3.36708230
43	negative regulation of ligase activity (GO:0051352)	3.36708230
44	antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)	3.34689969
45	signal transduction involved in cell cycle checkpoint (GO:0072395)	3.34621764
46	ATP synthesis coupled proton transport (GO:0015986)	3.33398536
47	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.33398536
48	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	3.31903373
49	regulation of immunoglobulin secretion (GO:0051023)	3.30028983
50	actin nucleation (GO:0045010)	3.28643254
51	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.28116811
52	actin-mediated cell contraction (GO:0070252)	3.27791692
53	muscle atrophy (GO:0014889)	3.26801516
54	negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)	3.25991795
55	sequestering of actin monomers (GO:0042989)	3.21290954
56	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.20632592
57	response to interferon-beta (GO:0035456)	3.14737370
58	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	3.09494543
59	antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)	3.07775384
60	pyrimidine ribonucleoside catabolic process (GO:0046133)	3.07396584
61	positive regulation of prostaglandin secretion (GO:0032308)	3.05893166
62	regulation of isotype switching to IgG isotypes (GO:0048302)	3.04806740
63	regulation of cellular amine metabolic process (GO:0033238)	3.04585444
64	response to muscle activity (GO:0014850)	3.03155030
65	response to testosterone (GO:0033574)	3.02668111
66	retina homeostasis (GO:0001895)	3.02660961
67	cellular response to interleukin-15 (GO:0071350)	3.02059282
68	protein-cofactor linkage (GO:0018065)	2.99557405
69	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	2.99182220
70	xenobiotic catabolic process (GO:0042178)	2.95201638
71	positive regulation of defense response to virus by host (GO:0002230)	2.92764726
72	signal peptide processing (GO:0006465)	2.90310918
73	regulation of chronic inflammatory response (GO:0002676)	2.89568205
74	positive regulation of ligase activity (GO:0051351)	2.89498055
75	DNA damage response, signal transduction by p53 class mediator (GO:0030330)	2.84905468
76	mannosylation (GO:0097502)	2.79065002
77	positive regulation of cell cycle arrest (GO:0071158)	2.78514611
78	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.76645820
79	mitochondrial calcium ion homeostasis (GO:0051560)	2.76599401
80	protein complex biogenesis (GO:0070271)	2.74957463
81	cellular response to interferon-beta (GO:0035458)	2.72817305
82	negative regulation of calcium ion transport into cytosol (GO:0010523)	2.67180878
83	regulation of prostaglandin secretion (GO:0032306)	2.66815157
84	rRNA modification (GO:0000154)	2.66360524
85	amino acid salvage (GO:0043102)	2.65673309
86	L-methionine salvage (GO:0071267)	2.65673309
87	L-methionine biosynthetic process (GO:0071265)	2.65673309
88	positive regulation of leukocyte mediated cytotoxicity (GO:0001912)	2.64375672
89	chaperone-mediated protein transport (GO:0072321)	2.64375409
90	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	2.61842980
91	positive regulation of actin filament depolymerization (GO:0030836)	2.61691458
92	regulation of leukocyte mediated cytotoxicity (GO:0001910)	2.61041113
93	protein polyglutamylation (GO:0018095)	2.60912507
94	protein maturation by protein folding (GO:0022417)	2.58307801
95	branched-chain amino acid catabolic process (GO:0009083)	2.57423900
96	base-excision repair, AP site formation (GO:0006285)	2.57098231
97	detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)	2.54766042
98	mast cell degranulation (GO:0043303)	2.52628018
99	mast cell activation involved in immune response (GO:0002279)	2.52628018
100	NADH dehydrogenase complex assembly (GO:0010257)	2.50968225

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.70543023
2	VDR_22108803_ChIP-Seq_LS180_Human	4.14332313
3	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	4.10407412
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.00024638
5	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.69903887
6	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.31404391
7	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.17141533
8	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.95044982
9	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.92434464
10	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	2.81511080
11	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.69620557
12	VDR_23849224_ChIP-Seq_CD4+_Human	2.69199119
13	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.68928521
14	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.66451980
15	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.58300253
16	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.53815169
17	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.46923533
18	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.39850806
19	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.32749753
20	ELK1_19687146_ChIP-ChIP_HELA_Human	2.20531047
21	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	2.14644128
22	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.07074669
23	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.04109594
24	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.01695607
25	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.95402014
26	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.94850720
27	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.92039968
28	TAF15_26573619_Chip-Seq_HEK293_Human	1.91253950
29	FOXP3_21729870_ChIP-Seq_TREG_Human	1.84103963
30	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.78274239
31	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.72814994
32	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.68201913
33	MYB_26560356_Chip-Seq_TH2_Human	1.66326558
34	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.59930912
35	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.54921266
36	ZNF274_21170338_ChIP-Seq_K562_Hela	1.54756143
37	GATA3_26560356_Chip-Seq_TH2_Human	1.51709107
38	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.51515618
39	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.50578937
40	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.50217785
41	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.49676514
42	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.46778034
43	AR_20517297_ChIP-Seq_VCAP_Human	1.44354372
44	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.43313739
45	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.40467133
46	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.39856614
47	CIITA_25753668_ChIP-Seq_RAJI_Human	1.36520648
48	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.35075908
49	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.33231707
50	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.32421716
51	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.32068367
52	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.30615786
53	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.30169115
54	MYC_18940864_ChIP-ChIP_HL60_Human	1.27072286
55	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	1.26411016
56	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.25648113
57	DCP1A_22483619_ChIP-Seq_HELA_Human	1.25345405
58	GABP_19822575_ChIP-Seq_HepG2_Human	1.23605964
59	ATF3_23680149_ChIP-Seq_GBM1-GSC_Human	1.20115946
60	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.16736216
61	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.14780225
62	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.13787318
63	TP53_22573176_ChIP-Seq_HFKS_Human	1.10953706
64	SPI1_23547873_ChIP-Seq_NB4_Human	1.09072889
65	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.09069057
66	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.07427667
67	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	1.06804199
68	RUNX_20019798_ChIP-Seq_JUKART_Human	1.06777158
69	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.06743743
70	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.05739583
71	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.05650897
72	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.05459145
73	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.04334069
74	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.02952997
75	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.02094635
76	ERG_20517297_ChIP-Seq_VCAP_Human	1.00533740
77	MYC_19829295_ChIP-Seq_ESCs_Human	0.99777807
78	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.99307706
79	RUNX1_17652178_ChIP-ChIP_JURKAT_Human	0.98954328
80	ZFP57_27257070_Chip-Seq_ESCs_Mouse	0.96837658
81	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	0.95463520
82	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	0.95363689
83	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.95167808
84	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.95167808
85	MEIS1_20887958_ChIP-Seq_HPC-7_Mouse	0.92871671
86	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.90952419
87	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.89866444
88	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.89316407
89	NANOG_20526341_ChIP-Seq_ESCs_Human	0.88089418
90	GATA3_27048872_Chip-Seq_THYMUS_Human	0.86519333
91	BCL6_27268052_Chip-Seq_Bcells_Human	0.86329571
92	MYB_26560356_Chip-Seq_TH1_Human	0.84189828
93	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	0.84066185
94	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	0.83962393
95	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.83405114
96	SALL4_22934838_ChIP-ChIP_CD34+_Human	0.82839646
97	E2F4_17652178_ChIP-ChIP_JURKAT_Human	0.82491360
98	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.82427164
99	NANOG_19829295_ChIP-Seq_ESCs_Human	0.81984623
100	SOX2_19829295_ChIP-Seq_ESCs_Human	0.81984623

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005671_abnormal_response_to	3.64655587
2	MP0001835_abnormal_antigen_presentation	3.41398881
3	MP0004147_increased_porphyrin_level	3.30347389
4	MP0004145_abnormal_muscle_electrophysio	3.11050647
5	MP0000685_abnormal_immune_system	2.66273066
6	MP0003724_increased_susceptibility_to	2.46931150
7	MP0000372_irregular_coat_pigmentation	2.41557475
8	MP0000747_muscle_weakness	2.33461313
9	MP0002166_altered_tumor_susceptibility	2.29617484
10	MP0005387_immune_system_phenotype	2.24017480
11	MP0001790_abnormal_immune_system	2.24017480
12	MP0000749_muscle_degeneration	2.23908170
13	MP0008875_abnormal_xenobiotic_pharmacok	2.20958043
14	MP0002102_abnormal_ear_morphology	2.14099432
15	MP0005000_abnormal_immune_tolerance	2.03387564
16	MP0005645_abnormal_hypothalamus_physiol	2.03300920
17	MP0002148_abnormal_hypersensitivity_rea	2.03268577
18	MP0003646_muscle_fatigue	2.01207394
19	MP0004036_abnormal_muscle_relaxation	2.00389353
20	MP0001800_abnormal_humoral_immune	2.00354322
21	MP0003436_decreased_susceptibility_to	1.98311501
22	MP0009785_altered_susceptibility_to	1.92275669
23	MP0002723_abnormal_immune_serum	1.91346306
24	MP0002736_abnormal_nociception_after	1.87190265
25	MP0003763_abnormal_thymus_physiology	1.78346777
26	MP0001853_heart_inflammation	1.77498999
27	MP0005083_abnormal_biliary_tract	1.73356326
28	MP0002006_tumorigenesis	1.70762590
29	MP0003786_premature_aging	1.70246262
30	MP0008872_abnormal_physiological_respon	1.67186934
31	MP0006036_abnormal_mitochondrial_physio	1.65078645
32	MP0003195_calcinosis	1.63391602
33	MP0005084_abnormal_gallbladder_morpholo	1.60725625
34	MP0002452_abnormal_antigen_presenting	1.60458006
35	MP0000465_gastrointestinal_hemorrhage	1.56348598
36	MP0006072_abnormal_retinal_apoptosis	1.53624210
37	MP0001968_abnormal_touch/_nociception	1.53583895
38	MP0002420_abnormal_adaptive_immunity	1.50458388
39	MP0001819_abnormal_immune_cell	1.49838330
40	MP0001873_stomach_inflammation	1.45296668
41	MP0003950_abnormal_plasma_membrane	1.44790489
42	MP0001243_abnormal_dermal_layer	1.44247259
43	MP0001905_abnormal_dopamine_level	1.41702685
44	MP0003191_abnormal_cellular_cholesterol	1.41041148
45	MP0003806_abnormal_nucleotide_metabolis	1.38015738
46	MP0002837_dystrophic_cardiac_calcinosis	1.36017610
47	MP0002638_abnormal_pupillary_reflex	1.35863179
48	MP0009333_abnormal_splenocyte_physiolog	1.35855765
49	MP0002106_abnormal_muscle_physiology	1.31343599
50	MP0002269_muscular_atrophy	1.30670748
51	MP0009764_decreased_sensitivity_to	1.30510761
52	MP0002876_abnormal_thyroid_physiology	1.28993658
53	MP0005025_abnormal_response_to	1.23413246
54	MP0001533_abnormal_skeleton_physiology	1.23343807
55	MP0000751_myopathy	1.22978277
56	MP0002095_abnormal_skin_pigmentation	1.20630192
57	MP0005620_abnormal_muscle_contractility	1.19091544
58	MP0002419_abnormal_innate_immunity	1.17397534
59	MP0002405_respiratory_system_inflammati	1.15335553
60	MP0006054_spinal_hemorrhage	1.14957226
61	MP0000689_abnormal_spleen_morphology	1.12830022
62	MP0003638_abnormal_response/metabolism_	1.11883598
63	MP0005075_abnormal_melanosome_morpholog	1.07264816
64	MP0002822_catalepsy	1.06943772
65	MP0004947_skin_inflammation	1.06736249
66	MP0001845_abnormal_inflammatory_respons	1.06359460
67	MP0002138_abnormal_hepatobiliary_system	1.06274573
68	MP0006035_abnormal_mitochondrial_morpho	1.04021980
69	MP0002398_abnormal_bone_marrow	1.03977457
70	MP0002722_abnormal_immune_system	1.02788944
71	MP0000716_abnormal_immune_system	1.02724438
72	MP0005464_abnormal_platelet_physiology	1.02488308
73	MP0005167_abnormal_blood-brain_barrier	1.02180921
74	MP0000759_abnormal_skeletal_muscle	1.02081271
75	MP0002254_reproductive_system_inflammat	1.01863821
76	MP0010155_abnormal_intestine_physiology	1.01164672
77	MP0005165_increased_susceptibility_to	1.00476548
78	MP0003866_abnormal_defecation	0.99760379
79	MP0003718_maternal_effect	0.97885727
80	MP0003045_fibrosis	0.96394571
81	MP0005253_abnormal_eye_physiology	0.96201179
82	MP0002933_joint_inflammation	0.94111392
83	MP0008058_abnormal_DNA_repair	0.92267960
84	MP0008775_abnormal_heart_ventricle	0.90297787
85	MP0008469_abnormal_protein_level	0.89736238
86	MP0005636_abnormal_mineral_homeostasis	0.89631921
87	MP0001879_abnormal_lymphatic_vessel	0.88385412
88	MP0005369_muscle_phenotype	0.87166220
89	MP0000703_abnormal_thymus_morphology	0.86782774
90	MP0008789_abnormal_olfactory_epithelium	0.86347346
91	MP0001542_abnormal_bone_strength	0.84597585
92	MP0002277_abnormal_respiratory_mucosa	0.84205960
93	MP0002429_abnormal_blood_cell	0.84195189
94	MP0000750_abnormal_muscle_regeneration	0.82697137
95	MP0004484_altered_response_of	0.81450161
96	MP0005551_abnormal_eye_electrophysiolog	0.81329055
97	MP0004142_abnormal_muscle_tone	0.80310642
98	MP0001529_abnormal_vocalization	0.77200378
99	MP0005646_abnormal_pituitary_gland	0.74718602
100	MP0000427_abnormal_hair_cycle	0.74018008

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Palpebral edema (HP:0100540)	4.40182414
2	Elevated erythrocyte sedimentation rate (HP:0003565)	4.12627476
3	IgG deficiency (HP:0004315)	4.03599306
4	Nemaline bodies (HP:0003798)	3.87094207
5	3-Methylglutaconic aciduria (HP:0003535)	3.56475159
6	Mitochondrial inheritance (HP:0001427)	3.55566715
7	Absent phalangeal crease (HP:0006109)	3.48729047
8	Hepatocellular necrosis (HP:0001404)	3.41673725
9	Increased CSF lactate (HP:0002490)	3.36755743
10	Distal arthrogryposis (HP:0005684)	3.36474512
11	Acute necrotizing encephalopathy (HP:0006965)	3.28922955
12	Hepatic necrosis (HP:0002605)	3.27676403
13	Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)	3.17672062
14	Lipid accumulation in hepatocytes (HP:0006561)	3.16574795
15	Muscle fiber inclusion bodies (HP:0100299)	3.14375913
16	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	3.09494932
17	Abnormality of alanine metabolism (HP:0010916)	3.09494932
18	Hyperalaninemia (HP:0003348)	3.09494932
19	Increased hepatocellular lipid droplets (HP:0006565)	3.08476743
20	Ulnar deviation of the wrist (HP:0003049)	2.90621467
21	Abnormal mitochondria in muscle tissue (HP:0008316)	2.89402518
22	Increased serum lactate (HP:0002151)	2.85731942
23	Abnormal finger flexion creases (HP:0006143)	2.82352497
24	Increased IgM level (HP:0003496)	2.82034177
25	Acute encephalopathy (HP:0006846)	2.79847438
26	Exertional dyspnea (HP:0002875)	2.78520572
27	Exercise-induced myalgia (HP:0003738)	2.77048669
28	Round ear (HP:0100830)	2.70706261
29	Type I transferrin isoform profile (HP:0003642)	2.68919555
30	Renal Fanconi syndrome (HP:0001994)	2.67359496
31	Progressive macrocephaly (HP:0004481)	2.66451941
32	Stomatitis (HP:0010280)	2.63377651
33	Exercise-induced muscle cramps (HP:0003710)	2.63368136
34	Progressive microcephaly (HP:0000253)	2.62053694
35	Lactic acidosis (HP:0003128)	2.51331458
36	Conical tooth (HP:0000698)	2.51295665
37	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.50210697
38	Abnormal protein glycosylation (HP:0012346)	2.48696230
39	Abnormal glycosylation (HP:0012345)	2.48696230
40	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.48696230
41	Abnormal protein N-linked glycosylation (HP:0012347)	2.48696230
42	Increased serum pyruvate (HP:0003542)	2.48347127
43	Myoglobinuria (HP:0002913)	2.47018275
44	Abnormality of the prostate (HP:0008775)	2.43909809
45	Severe combined immunodeficiency (HP:0004430)	2.39934746
46	Periorbital edema (HP:0100539)	2.34306156
47	Exercise intolerance (HP:0003546)	2.32411222
48	Congenital, generalized hypertrichosis (HP:0004540)	2.32236962
49	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.28129952
50	Methylmalonic aciduria (HP:0012120)	2.27393080
51	Facial edema (HP:0000282)	2.27014452
52	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.25633040
53	Rhabdomyolysis (HP:0003201)	2.25312908
54	Type 2 muscle fiber atrophy (HP:0003554)	2.25112659
55	Increased intramyocellular lipid droplets (HP:0012240)	2.23147742
56	Congenital stationary night blindness (HP:0007642)	2.21008637
57	Cerebral edema (HP:0002181)	2.16546266
58	Optic disc pallor (HP:0000543)	2.15506684
59	Renal cortical cysts (HP:0000803)	2.13223240
60	Reduced subcutaneous adipose tissue (HP:0003758)	2.10679310
61	Abolished electroretinogram (ERG) (HP:0000550)	2.10521441
62	Prostate neoplasm (HP:0100787)	2.09575849
63	Opisthotonus (HP:0002179)	2.08819619
64	Abnormality of glycolysis (HP:0004366)	2.07750049
65	Fatigue (HP:0012378)	2.07538820
66	Muscle fiber atrophy (HP:0100295)	2.06077263
67	Hypoproteinemia (HP:0003075)	2.03482394
68	Increased muscle lipid content (HP:0009058)	2.02417048
69	Cholecystitis (HP:0001082)	2.01950908
70	Abnormal gallbladder physiology (HP:0012438)	2.01950908
71	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.01434827
72	Deformed tarsal bones (HP:0008119)	2.00084265
73	Respiratory failure (HP:0002878)	1.98088706
74	Paralysis (HP:0003470)	1.95003555
75	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.94699964
76	Dicarboxylic aciduria (HP:0003215)	1.94699964
77	Chronic diarrhea (HP:0002028)	1.94206399
78	Abnormality of T cells (HP:0002843)	1.93539286
79	Methylmalonic acidemia (HP:0002912)	1.92434828
80	Neuroendocrine neoplasm (HP:0100634)	1.92374035
81	Hepatosplenomegaly (HP:0001433)	1.92121603
82	Cerebral hypomyelination (HP:0006808)	1.90425923
83	Lethargy (HP:0001254)	1.88529642
84	IgM deficiency (HP:0002850)	1.85982770
85	Brittle hair (HP:0002299)	1.83143538
86	Mask-like facies (HP:0000298)	1.81661228
87	Metabolic acidosis (HP:0001942)	1.81389585
88	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.80625187
89	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.80625187
90	Abnormality of T cell physiology (HP:0011840)	1.80330092
91	Calcaneovalgus deformity (HP:0001848)	1.80255808
92	Fibular aplasia (HP:0002990)	1.79831637
93	Cerebral hemorrhage (HP:0001342)	1.78324061
94	CNS demyelination (HP:0007305)	1.76685106
95	Poor speech (HP:0002465)	1.74679311
96	Joint swelling (HP:0001386)	1.73482626
97	Constricted visual fields (HP:0001133)	1.73346399
98	Aplastic anemia (HP:0001915)	1.72785574
99	Oligomenorrhea (HP:0000876)	1.72466308
100	Abnormal rod and cone electroretinograms (HP:0008323)	1.72285243

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TESK2	4.29897726
2	VRK2	3.98933422
3	TLK1	3.28483910
4	TESK1	3.18533597
5	TXK	3.02012351
6	MAP4K2	3.01616835
7	LIMK1	2.95032338
8	TAOK3	2.52023898
9	PHKG2	2.49011274
10	PHKG1	2.49011274
11	BCKDK	2.42942996
12	ZAK	2.42327920
13	VRK1	2.13623500
14	MST4	2.03569556
15	KDR	1.98683444
16	TIE1	1.92281660
17	NUAK1	1.91528568
18	MAP3K12	1.78459598
19	NEK1	1.63666814
20	MAP3K14	1.62432877
21	MAPKAPK3	1.62212383
22	DAPK1	1.62169874
23	OBSCN	1.43526258
24	SRPK1	1.42205461
25	BUB1	1.38061136
26	WNK4	1.37955798
27	PDK2	1.24510824
28	IKBKB	1.21591862
29	ADRBK2	1.19771036
30	TBK1	1.19110040
31	IKBKE	1.18925180
32	CSNK1G3	1.11707464
33	EIF2AK3	1.09008037
34	FES	1.06540030
35	EIF2AK2	1.05978344
36	CCNB1	1.03054646
37	CSNK1A1L	1.02860909
38	GRK1	1.01353161
39	MYLK	0.99301492
40	OXSR1	0.93897309
41	TEC	0.92849534
42	TAF1	0.90214505
43	MAP2K2	0.88624858
44	STK39	0.86671747
45	MAPK13	0.84879288
46	CSNK1G1	0.84044635
47	NME2	0.83687728
48	BMPR2	0.82763738
49	SCYL2	0.82020241
50	CAMKK2	0.81802499
51	CSNK1G2	0.80914198
52	TRIM28	0.80914125
53	RPS6KA5	0.80352049
54	JAK3	0.77610842
55	CDK8	0.76631002
56	PTK2B	0.76509796
57	TSSK6	0.75055852
58	PIK3CG	0.71729849
59	GRK6	0.70796612
60	MAP2K7	0.69545843
61	PIM2	0.68503961
62	AURKA	0.66912816
63	LMTK2	0.66556934
64	STK16	0.57876659
65	MAPKAPK5	0.57129420
66	ERBB3	0.56677049
67	PLK3	0.56525956
68	GRK5	0.55137295
69	ITK	0.52707289
70	SYK	0.52171165
71	SIK3	0.49344792
72	KIT	0.46859054
73	MUSK	0.46384703
74	DAPK3	0.45401899
75	DYRK2	0.44803622
76	MAP4K1	0.44561059
77	DAPK2	0.43266360
78	PRKCQ	0.43098026
79	INSRR	0.42497743
80	ILK	0.42125616
81	CSF1R	0.41075811
82	ARAF	0.41030805
83	IGF1R	0.39482985
84	BCR	0.38730861
85	LCK	0.37492945
86	ADRBK1	0.36491729
87	PBK	0.35898008
88	CSK	0.35483824
89	EIF2AK1	0.35393630
90	TRPM7	0.35232264
91	ABL2	0.35076712
92	LYN	0.34326886
93	CAMK2G	0.30521424
94	CHUK	0.30460405
95	MAPKAPK2	0.29582559
96	ATR	0.27725308
97	ABL1	0.27679983
98	GRK7	0.24807271
99	EPHA2	0.23933958
100	WNK3	0.23438329

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	5.41224210
2	Oxidative phosphorylation_Homo sapiens_hsa00190	2.80304111
3	Asthma_Homo sapiens_hsa05310	2.75339495
4	Allograft rejection_Homo sapiens_hsa05330	2.61434867
5	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.55203612
6	Parkinsons disease_Homo sapiens_hsa05012	2.51734322
7	Protein export_Homo sapiens_hsa03060	2.50650082
8	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.42553120
9	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	2.28727085
10	Primary immunodeficiency_Homo sapiens_hsa05340	2.19872010
11	Antigen processing and presentation_Homo sapiens_hsa04612	2.00094383
12	Graft-versus-host disease_Homo sapiens_hsa05332	1.99010356
13	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.95251686
14	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.93862772
15	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.88175461
16	Fatty acid elongation_Homo sapiens_hsa00062	1.88163637
17	Type I diabetes mellitus_Homo sapiens_hsa04940	1.66258157
18	RNA polymerase_Homo sapiens_hsa03020	1.65093159
19	Alzheimers disease_Homo sapiens_hsa05010	1.56074155
20	Regulation of autophagy_Homo sapiens_hsa04140	1.51822037
21	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.46173541
22	Huntingtons disease_Homo sapiens_hsa05016	1.44130274
23	Caffeine metabolism_Homo sapiens_hsa00232	1.39362879
24	Viral myocarditis_Homo sapiens_hsa05416	1.32982451
25	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.27809191
26	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.26608079
27	Rheumatoid arthritis_Homo sapiens_hsa05323	1.22855908
28	Nitrogen metabolism_Homo sapiens_hsa00910	1.15985199
29	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.12538636
30	NF-kappa B signaling pathway_Homo sapiens_hsa04064	1.10150834
31	RNA degradation_Homo sapiens_hsa03018	1.05359421
32	Peroxisome_Homo sapiens_hsa04146	1.01847573
33	Sulfur metabolism_Homo sapiens_hsa00920	0.98044323
34	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.96189609
35	Tryptophan metabolism_Homo sapiens_hsa00380	0.96109204
36	Phototransduction_Homo sapiens_hsa04744	0.94605688
37	Basal transcription factors_Homo sapiens_hsa03022	0.93966330
38	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.93875656
39	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.93777214
40	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.93651840
41	Cardiac muscle contraction_Homo sapiens_hsa04260	0.92484975
42	Collecting duct acid secretion_Homo sapiens_hsa04966	0.91791506
43	Purine metabolism_Homo sapiens_hsa00230	0.91396445
44	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.91225350
45	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.90525852
46	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.90200663
47	Glutathione metabolism_Homo sapiens_hsa00480	0.90037509
48	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.89561915
49	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.89407639
50	Propanoate metabolism_Homo sapiens_hsa00640	0.87958565
51	Base excision repair_Homo sapiens_hsa03410	0.87489755
52	Homologous recombination_Homo sapiens_hsa03440	0.87360455
53	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.85014250
54	Spliceosome_Homo sapiens_hsa03040	0.85011528
55	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.83342131
56	DNA replication_Homo sapiens_hsa03030	0.83017515
57	Shigellosis_Homo sapiens_hsa05131	0.82081611
58	Pyrimidine metabolism_Homo sapiens_hsa00240	0.81739410
59	Mismatch repair_Homo sapiens_hsa03430	0.80850514
60	Chemical carcinogenesis_Homo sapiens_hsa05204	0.75034339
61	Carbon metabolism_Homo sapiens_hsa01200	0.74698415
62	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.72970247
63	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.72575944
64	RNA transport_Homo sapiens_hsa03013	0.71782841
65	Pyruvate metabolism_Homo sapiens_hsa00620	0.71453452
66	One carbon pool by folate_Homo sapiens_hsa00670	0.70368903
67	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.67719926
68	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.64650816
69	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.61948697
70	Salivary secretion_Homo sapiens_hsa04970	0.61485916
71	Fanconi anemia pathway_Homo sapiens_hsa03460	0.59352276
72	Linoleic acid metabolism_Homo sapiens_hsa00591	0.59216608
73	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.57746535
74	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.56525934
75	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.55134409
76	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.54474194
77	Nucleotide excision repair_Homo sapiens_hsa03420	0.54281148
78	Measles_Homo sapiens_hsa05162	0.54055357
79	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.52456926
80	Ribosome_Homo sapiens_hsa03010	0.51703182
81	Metabolic pathways_Homo sapiens_hsa01100	0.50999928
82	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.50782813
83	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.50704824
84	Legionellosis_Homo sapiens_hsa05134	0.50565362
85	Pentose phosphate pathway_Homo sapiens_hsa00030	0.49327165
86	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.48960772
87	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.47978027
88	Vibrio cholerae infection_Homo sapiens_hsa05110	0.47663939
89	Herpes simplex infection_Homo sapiens_hsa05168	0.46680736
90	Arginine and proline metabolism_Homo sapiens_hsa00330	0.44563286
91	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.41857604
92	Tight junction_Homo sapiens_hsa04530	0.38333215
93	Circadian rhythm_Homo sapiens_hsa04710	0.38241496
94	Butanoate metabolism_Homo sapiens_hsa00650	0.35744691
95	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.35598049
96	Olfactory transduction_Homo sapiens_hsa04740	0.35225185
97	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.34961868
98	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.29845568
99	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.29324550
100	beta-Alanine metabolism_Homo sapiens_hsa00410	0.26585726

ACTG1P21

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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