ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	histone H2A acetylation (GO:0043968)	5.16125937
2	DNA deamination (GO:0045006)	4.88982370
3	negative regulation of heart rate (GO:0010459)	4.63644006
4	behavioral response to nicotine (GO:0035095)	4.56749924
5	urate metabolic process (GO:0046415)	4.42335920
6	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	4.41301948
7	sleep (GO:0030431)	4.25961171
8	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	4.23268330
9	platelet dense granule organization (GO:0060155)	4.18147056
10	piRNA metabolic process (GO:0034587)	3.97283167
11	phosphate ion transport (GO:0006817)	3.74489693
12	cytidine metabolic process (GO:0046087)	3.59720636
13	cytidine catabolic process (GO:0006216)	3.59720636
14	cytidine deamination (GO:0009972)	3.59720636
15	tachykinin receptor signaling pathway (GO:0007217)	3.48314486
16	adenosine metabolic process (GO:0046085)	3.48048026
17	positive regulation of T cell cytokine production (GO:0002726)	3.42648348
18	positive regulation of alpha-beta T cell proliferation (GO:0046641)	3.40881058
19	regulation of hippo signaling (GO:0035330)	3.39605673
20	regulation of natural killer cell differentiation (GO:0032823)	3.27410245
21	peptidyl-tyrosine autophosphorylation (GO:0038083)	3.23823938
22	pyrimidine ribonucleoside catabolic process (GO:0046133)	3.22555284
23	detection of light stimulus involved in sensory perception (GO:0050962)	3.22377437
24	detection of light stimulus involved in visual perception (GO:0050908)	3.22377437
25	positive regulation of uterine smooth muscle contraction (GO:0070474)	3.17561244
26	positive regulation of mitochondrial fission (GO:0090141)	3.16643629
27	proteasome assembly (GO:0043248)	3.14603527
28	iron-sulfur cluster assembly (GO:0016226)	3.09653187
29	metallo-sulfur cluster assembly (GO:0031163)	3.09653187
30	dopamine transport (GO:0015872)	3.05913060
31	negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)	3.03284971
32	cellular response to interleukin-15 (GO:0071350)	2.97120685
33	positive regulation of T-helper 1 type immune response (GO:0002827)	2.96130271
34	sequestering of actin monomers (GO:0042989)	2.91546067
35	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.90692006
36	regulation of mitotic spindle checkpoint (GO:1903504)	2.90692006
37	regulation of alpha-beta T cell proliferation (GO:0046640)	2.87811257
38	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.87544831
39	water-soluble vitamin biosynthetic process (GO:0042364)	2.87322681
40	positive regulation of action potential (GO:0045760)	2.86042800
41	aminoglycoside antibiotic metabolic process (GO:0030647)	2.85338133
42	DNA methylation involved in gamete generation (GO:0043046)	2.84788275
43	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.79913809
44	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.79913809
45	anterograde synaptic vesicle transport (GO:0048490)	2.79850541
46	negative regulation of telomere maintenance (GO:0032205)	2.78508162
47	regulation of immunoglobulin secretion (GO:0051023)	2.78289970
48	fucose catabolic process (GO:0019317)	2.77294845
49	L-fucose metabolic process (GO:0042354)	2.77294845
50	L-fucose catabolic process (GO:0042355)	2.77294845
51	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	2.75121831
52	base-excision repair, AP site formation (GO:0006285)	2.74875739
53	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	2.71296389
54	cullin deneddylation (GO:0010388)	2.69872235
55	pyrimidine dimer repair (GO:0006290)	2.67398898
56	adaptation of signaling pathway (GO:0023058)	2.63957685
57	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.61947021
58	isotype switching (GO:0045190)	2.61947021
59	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.61947021
60	regulation of T-helper 1 type immune response (GO:0002825)	2.58974858
61	negative regulation of JAK-STAT cascade (GO:0046426)	2.56961497
62	protein-cofactor linkage (GO:0018065)	2.56336772
63	protein K6-linked ubiquitination (GO:0085020)	2.55975412
64	methionine biosynthetic process (GO:0009086)	2.55677483
65	rRNA methylation (GO:0031167)	2.54324776
66	positive regulation of T cell mediated cytotoxicity (GO:0001916)	2.53489691
67	regulation of dopamine metabolic process (GO:0042053)	2.51495196
68	regulation of catecholamine metabolic process (GO:0042069)	2.51495196
69	protein deneddylation (GO:0000338)	2.50566590
70	organelle disassembly (GO:1903008)	2.49945967
71	regulation of action potential (GO:0098900)	2.49511391
72	mannosylation (GO:0097502)	2.49409683
73	pseudouridine synthesis (GO:0001522)	2.49395274
74	head development (GO:0060322)	2.48699978
75	regulation of cellular amino acid metabolic process (GO:0006521)	2.47985031
76	protein localization to cilium (GO:0061512)	2.47846018
77	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.46947851
78	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.46947851
79	NADH dehydrogenase complex assembly (GO:0010257)	2.46947851
80	regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003339	2.44884062
81	positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)	2.44227701
82	rRNA modification (GO:0000154)	2.43936506
83	negative regulation of mast cell activation (GO:0033004)	2.41873286
84	photoreceptor cell development (GO:0042461)	2.41639421
85	response to interleukin-15 (GO:0070672)	2.40403583
86	indole-containing compound metabolic process (GO:0042430)	2.40308399
87	glycerophospholipid catabolic process (GO:0046475)	2.39512416
88	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.39464905
89	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.38360732
90	pentose metabolic process (GO:0019321)	2.38187243
91	regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)	2.35402376
92	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.34377910
93	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.34377910
94	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.34377910
95	regulation of memory T cell differentiation (GO:0043380)	2.34272072
96	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.34110132
97	regulation of mitochondrial fission (GO:0090140)	2.32911611
98	regulation of B cell receptor signaling pathway (GO:0050855)	2.32564087
99	response to pheromone (GO:0019236)	2.32038284
100	positive regulation of defense response to virus by host (GO:0002230)	2.31907611

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GATA1_22025678_ChIP-Seq_K562_Human	5.35760327
2	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	3.99433336
3	ZNF274_21170338_ChIP-Seq_K562_Hela	3.89624256
4	VDR_22108803_ChIP-Seq_LS180_Human	3.88238835
5	IRF8_22096565_ChIP-ChIP_GC-B_Human	3.24206661
6	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.07730727
7	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.98534178
8	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.62193792
9	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.55451422
10	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.45510707
11	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.44696312
12	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.31676049
13	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	2.26022067
14	VDR_23849224_ChIP-Seq_CD4+_Human	2.22138886
15	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.02043370
16	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.97136593
17	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.93708883
18	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.84067636
19	EZH2_22144423_ChIP-Seq_EOC_Human	1.79952066
20	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.79453997
21	RUNX_20019798_ChIP-Seq_JUKART_Human	1.78623965
22	MYC_18940864_ChIP-ChIP_HL60_Human	1.77183551
23	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.70996562
24	GBX2_23144817_ChIP-Seq_PC3_Human	1.70859608
25	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.69153487
26	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.65675000
27	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.65009280
28	ELK1_19687146_ChIP-ChIP_HELA_Human	1.62785348
29	GATA3_26560356_Chip-Seq_TH2_Human	1.56813117
30	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.56068569
31	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.54175777
32	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.53664781
33	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.53116382
34	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.52607779
35	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.45888986
36	ER_23166858_ChIP-Seq_MCF-7_Human	1.45374381
37	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.45002575
38	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.43467729
39	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.40563553
40	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.39317957
41	FUS_26573619_Chip-Seq_HEK293_Human	1.38744322
42	EWS_26573619_Chip-Seq_HEK293_Human	1.38686649
43	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.38144453
44	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.37515170
45	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.36756919
46	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.36550390
47	NCOR_22424771_ChIP-Seq_293T_Human	1.36487815
48	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.33548095
49	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.33536370
50	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.31870326
51	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.30940089
52	IRF1_19129219_ChIP-ChIP_H3396_Human	1.30401645
53	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.28156358
54	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.26232990
55	SOX2_19829295_ChIP-Seq_ESCs_Human	1.24777558
56	NANOG_19829295_ChIP-Seq_ESCs_Human	1.24777558
57	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.24558448
58	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.24347992
59	FOXP3_21729870_ChIP-Seq_TREG_Human	1.24121070
60	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.21278005
61	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.20567663
62	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.20442850
63	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.20442850
64	AR_20517297_ChIP-Seq_VCAP_Human	1.17754738
65	TP53_22573176_ChIP-Seq_HFKS_Human	1.17533482
66	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.14054275
67	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.12036391
68	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.11397255
69	P300_19829295_ChIP-Seq_ESCs_Human	1.10532885
70	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.09888427
71	HOXB7_26014856_ChIP-Seq_BT474_Human	1.09722752
72	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.08686133
73	TCF4_22108803_ChIP-Seq_LS180_Human	1.07273972
74	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.06878365
75	MYB_26560356_Chip-Seq_TH2_Human	1.05960978
76	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.05693588
77	FOXH1_21741376_ChIP-Seq_ESCs_Human	1.03772201
78	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.03663621
79	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.02027634
80	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.01869218
81	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.00216019
82	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.00192996
83	OCT4_20526341_ChIP-Seq_ESCs_Human	0.97567470
84	BCAT_22108803_ChIP-Seq_LS180_Human	0.95728407
85	IKZF1_21737484_ChIP-ChIP_HCT116_Human	0.95346674
86	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.93468151
87	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.92425417
88	BP1_19119308_ChIP-ChIP_Hs578T_Human	0.92348505
89	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.90840447
90	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.90376140
91	ERA_21632823_ChIP-Seq_H3396_Human	0.89579024
92	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.89295567
93	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.89158071
94	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.88082832
95	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.87194480
96	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.87071514
97	IGF1R_20145208_ChIP-Seq_DFB_Human	0.86815268
98	GATA3_27048872_Chip-Seq_THYMUS_Human	0.86414354
99	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.86285073
100	NANOG_20526341_ChIP-Seq_ESCs_Human	0.84901762

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005671_abnormal_response_to	3.76525624
2	MP0006072_abnormal_retinal_apoptosis	3.07487400
3	MP0002102_abnormal_ear_morphology	2.72423298
4	MP0008877_abnormal_DNA_methylation	2.66421934
5	MP0003763_abnormal_thymus_physiology	2.64396592
6	MP0005551_abnormal_eye_electrophysiolog	2.39298086
7	MP0005645_abnormal_hypothalamus_physiol	2.34295162
8	MP0004147_increased_porphyrin_level	2.31328519
9	MP0003878_abnormal_ear_physiology	2.17510993
10	MP0005377_hearing/vestibular/ear_phenot	2.17510993
11	MP0005253_abnormal_eye_physiology	2.13147866
12	MP0001835_abnormal_antigen_presentation	2.13011024
13	MP0002138_abnormal_hepatobiliary_system	2.10801296
14	MP0000372_irregular_coat_pigmentation	2.09066398
15	MP0000465_gastrointestinal_hemorrhage	1.91085003
16	MP0003011_delayed_dark_adaptation	1.87619834
17	MP0003195_calcinosis	1.80805498
18	MP0008872_abnormal_physiological_respon	1.80130254
19	MP0001800_abnormal_humoral_immune	1.70841966
20	MP0001545_abnormal_hematopoietic_system	1.65689510
21	MP0005397_hematopoietic_system_phenotyp	1.65689510
22	MP0009785_altered_susceptibility_to	1.64814641
23	MP0006035_abnormal_mitochondrial_morpho	1.63240070
24	MP0005000_abnormal_immune_tolerance	1.63015017
25	MP0002148_abnormal_hypersensitivity_rea	1.61893834
26	MP0006036_abnormal_mitochondrial_physio	1.61557799
27	MP0001486_abnormal_startle_reflex	1.60301866
28	MP0003806_abnormal_nucleotide_metabolis	1.59104803
29	MP0001501_abnormal_sleep_pattern	1.58448152
30	MP0003724_increased_susceptibility_to	1.58446724
31	MP0004215_abnormal_myocardial_fiber	1.57898401
32	MP0005167_abnormal_blood-brain_barrier	1.57562020
33	MP0004145_abnormal_muscle_electrophysio	1.56307108
34	MP0008875_abnormal_xenobiotic_pharmacok	1.52370955
35	MP0001986_abnormal_taste_sensitivity	1.47526287
36	MP0002332_abnormal_exercise_endurance	1.44009768
37	MP0002160_abnormal_reproductive_system	1.43043067
38	MP0000685_abnormal_immune_system	1.39475193
39	MP0005387_immune_system_phenotype	1.38911783
40	MP0001790_abnormal_immune_system	1.38911783
41	MP0002723_abnormal_immune_serum	1.37697149
42	MP0009764_decreased_sensitivity_to	1.36349227
43	MP0006276_abnormal_autonomic_nervous	1.33963675
44	MP0009333_abnormal_splenocyte_physiolog	1.32944294
45	MP0002736_abnormal_nociception_after	1.32080729
46	MP0005389_reproductive_system_phenotype	1.31258279
47	MP0002452_abnormal_antigen_presenting	1.31217279
48	MP0003045_fibrosis	1.26080862
49	MP0002006_tumorigenesis	1.26059860
50	MP0009046_muscle_twitch	1.24572282
51	MP0001819_abnormal_immune_cell	1.24076895
52	MP0002420_abnormal_adaptive_immunity	1.23637900
53	MP0003646_muscle_fatigue	1.20679879
54	MP0002735_abnormal_chemical_nociception	1.19388898
55	MP0002822_catalepsy	1.17380719
56	MP0009745_abnormal_behavioral_response	1.17315596
57	MP0002272_abnormal_nervous_system	1.16608502
58	MP0001764_abnormal_homeostasis	1.14515282
59	MP0002166_altered_tumor_susceptibility	1.13284529
60	MP0002733_abnormal_thermal_nociception	1.12542277
61	MP0003693_abnormal_embryo_hatching	1.11780408
62	MP0004142_abnormal_muscle_tone	1.09312739
63	MP0008775_abnormal_heart_ventricle	1.08699428
64	MP0005464_abnormal_platelet_physiology	1.06347666
65	MP0002638_abnormal_pupillary_reflex	1.05882715
66	MP0003252_abnormal_bile_duct	1.05872645
67	MP0002837_dystrophic_cardiac_calcinosis	1.05064869
68	MP0003137_abnormal_impulse_conducting	1.04445191
69	MP0005025_abnormal_response_to	1.04358170
70	MP0004019_abnormal_vitamin_homeostasis	1.04009906
71	MP0001968_abnormal_touch/_nociception	1.02843700
72	MP0005075_abnormal_melanosome_morpholog	1.02818353
73	MP0001873_stomach_inflammation	1.02020272
74	MP0000516_abnormal_urinary_system	0.94967530
75	MP0005367_renal/urinary_system_phenotyp	0.94967530
76	MP0005646_abnormal_pituitary_gland	0.93938749
77	MP0002398_abnormal_bone_marrow	0.93505859
78	MP0001845_abnormal_inflammatory_respons	0.92230203
79	MP0001970_abnormal_pain_threshold	0.90840770
80	MP0001905_abnormal_dopamine_level	0.90633044
81	MP0002909_abnormal_adrenal_gland	0.90042462
82	MP0004510_myositis	0.89949616
83	MP0001984_abnormal_olfaction	0.89791124
84	MP0001529_abnormal_vocalization	0.87964011
85	MP0000689_abnormal_spleen_morphology	0.86470717
86	MP0009765_abnormal_xenobiotic_induced	0.84049500
87	MP0001485_abnormal_pinna_reflex	0.82684588
88	MP0000015_abnormal_ear_pigmentation	0.82424915
89	MP0000716_abnormal_immune_system	0.82121022
90	MP0003866_abnormal_defecation	0.80218786
91	MP0002229_neurodegeneration	0.80082886
92	MP0005410_abnormal_fertilization	0.80034518
93	MP0010386_abnormal_urinary_bladder	0.78831675
94	MP0001919_abnormal_reproductive_system	0.78630164
95	MP0002572_abnormal_emotion/affect_behav	0.78068144
96	MP0004085_abnormal_heartbeat	0.77949880
97	MP0008058_abnormal_DNA_repair	0.77454010
98	MP0005332_abnormal_amino_acid	0.76684475
99	MP0004885_abnormal_endolymph	0.74087250
100	MP0003635_abnormal_synaptic_transmissio	0.73578048

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pendular nystagmus (HP:0012043)	5.11553236
2	Generalized aminoaciduria (HP:0002909)	4.69321954
3	Congenital stationary night blindness (HP:0007642)	4.16482641
4	Stomatitis (HP:0010280)	3.99810346
5	IgG deficiency (HP:0004315)	3.50335509
6	Pancreatic cysts (HP:0001737)	3.48241954
7	Abolished electroretinogram (ERG) (HP:0000550)	3.42857181
8	3-Methylglutaconic aciduria (HP:0003535)	3.42617617
9	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.34615243
10	True hermaphroditism (HP:0010459)	3.11531739
11	Attenuation of retinal blood vessels (HP:0007843)	3.03114441
12	Elevated erythrocyte sedimentation rate (HP:0003565)	3.02759163
13	Type II lissencephaly (HP:0007260)	3.02657433
14	Hepatic necrosis (HP:0002605)	2.99978245
15	Decreased central vision (HP:0007663)	2.92801442
16	Keratoconus (HP:0000563)	2.92330247
17	Increased corneal curvature (HP:0100692)	2.92330247
18	Abnormal rod and cone electroretinograms (HP:0008323)	2.90908810
19	Hepatocellular necrosis (HP:0001404)	2.89497191
20	Retinal dysplasia (HP:0007973)	2.86277577
21	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.81971198
22	Severe visual impairment (HP:0001141)	2.76287929
23	Increased IgM level (HP:0003496)	2.69783167
24	Renal cortical cysts (HP:0000803)	2.63598171
25	Pancreatic fibrosis (HP:0100732)	2.60011316
26	Abnormality of the labia minora (HP:0012880)	2.57650982
27	Proximal tubulopathy (HP:0000114)	2.56196105
28	Lissencephaly (HP:0001339)	2.53073650
29	Mitochondrial inheritance (HP:0001427)	2.52468516
30	Congenital, generalized hypertrichosis (HP:0004540)	2.47678385
31	Degeneration of anterior horn cells (HP:0002398)	2.28373675
32	Abnormality of the anterior horn cell (HP:0006802)	2.28373675
33	Parakeratosis (HP:0001036)	2.24308296
34	Dry hair (HP:0011359)	2.21831006
35	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.21791736
36	Clumsiness (HP:0002312)	2.20905194
37	Increased CSF lactate (HP:0002490)	2.19207863
38	Abnormality of the renal cortex (HP:0011035)	2.15984366
39	Increased serum lactate (HP:0002151)	2.15980119
40	Hypokalemic alkalosis (HP:0001949)	2.14101699
41	Tongue fasciculations (HP:0001308)	2.12719081
42	Sclerocornea (HP:0000647)	2.12218648
43	Prostate neoplasm (HP:0100787)	2.10856111
44	Type I transferrin isoform profile (HP:0003642)	2.09588067
45	Abnormality of T cell physiology (HP:0011840)	2.09295986
46	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.08141798
47	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.08141798
48	Stomach cancer (HP:0012126)	2.06693969
49	Abnormality of midbrain morphology (HP:0002418)	2.06179541
50	Molar tooth sign on MRI (HP:0002419)	2.06179541
51	Aplasia/hypoplasia of the uterus (HP:0008684)	2.05733801
52	Amniotic constriction ring (HP:0009775)	2.05564417
53	Abnormality of placental membranes (HP:0011409)	2.05564417
54	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.04190159
55	Abnormality of urine glucose concentration (HP:0011016)	2.04091861
56	Glycosuria (HP:0003076)	2.04091861
57	Acute necrotizing encephalopathy (HP:0006965)	2.03669639
58	Panhypogammaglobulinemia (HP:0003139)	2.01372092
59	Abnormal mitochondria in muscle tissue (HP:0008316)	1.99949789
60	Pachygyria (HP:0001302)	1.99670255
61	Medial flaring of the eyebrow (HP:0010747)	1.98998249
62	Abnormality of the fovea (HP:0000493)	1.97813244
63	Neonatal respiratory distress (HP:0002643)	1.97205337
64	Acute encephalopathy (HP:0006846)	1.95458536
65	Abnormality of T cells (HP:0002843)	1.94595550
66	Abnormality of alanine metabolism (HP:0010916)	1.94336233
67	Hyperalaninemia (HP:0003348)	1.94336233
68	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.94336233
69	Cystic liver disease (HP:0006706)	1.93443691
70	Delayed CNS myelination (HP:0002188)	1.91957389
71	Hypomagnesemia (HP:0002917)	1.90309723
72	Severe combined immunodeficiency (HP:0004430)	1.90267288
73	Constricted visual fields (HP:0001133)	1.88398792
74	Inability to walk (HP:0002540)	1.87030852
75	Hypothermia (HP:0002045)	1.86249274
76	Abnormality of methionine metabolism (HP:0010901)	1.86163059
77	Lactic acidosis (HP:0003128)	1.83769546
78	Abnormality of the renal collecting system (HP:0004742)	1.82072200
79	Progressive microcephaly (HP:0000253)	1.81141600
80	Homocystinuria (HP:0002156)	1.79997128
81	Abnormality of homocysteine metabolism (HP:0010919)	1.79997128
82	Bony spicule pigmentary retinopathy (HP:0007737)	1.79631128
83	Conical tooth (HP:0000698)	1.77935339
84	Chronic diarrhea (HP:0002028)	1.76752499
85	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.76271714
86	Abnormal biliary tract physiology (HP:0012439)	1.75731923
87	Bile duct proliferation (HP:0001408)	1.75731923
88	Recurrent cutaneous fungal infections (HP:0011370)	1.74985451
89	Chronic mucocutaneous candidiasis (HP:0002728)	1.74985451
90	Agitation (HP:0000713)	1.73718421
91	Myokymia (HP:0002411)	1.73508784
92	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.73350370
93	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.73274419
94	Abnormal protein N-linked glycosylation (HP:0012347)	1.73274419
95	Abnormal protein glycosylation (HP:0012346)	1.73274419
96	Abnormal glycosylation (HP:0012345)	1.73274419
97	Muscle fibrillation (HP:0010546)	1.72881158
98	Abnormality of the prostate (HP:0008775)	1.72121518
99	Chronic hepatic failure (HP:0100626)	1.71472509
100	Abnormality of serum amino acid levels (HP:0003112)	1.71357115

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TAOK3	5.02914334
2	MAP4K2	4.73719250
3	TXK	4.14757264
4	ZAK	2.49254364
5	PINK1	2.48412679
6	TRIM28	2.40324039
7	MST4	2.35890658
8	TLK1	2.14726822
9	ADRBK2	2.05437580
10	MAP3K12	2.03548747
11	BCKDK	2.03490206
12	FRK	1.96249926
13	NUAK1	1.93166368
14	TIE1	1.88626701
15	TESK2	1.86966351
16	MAP4K1	1.82829845
17	BMPR1B	1.73528261
18	VRK2	1.70113117
19	GRK1	1.49253932
20	CDK19	1.44628551
21	KDR	1.38010815
22	CSNK1G3	1.35342242
23	SRPK1	1.33960917
24	OXSR1	1.26980437
25	MAPKAPK3	1.25636807
26	FES	1.21507420
27	STK39	1.20268723
28	TEC	1.19453601
29	EIF2AK3	1.19273028
30	GRK6	1.16393663
31	DAPK1	1.15759489
32	CSNK1G2	1.12985160
33	EPHA3	1.12875536
34	MYLK	1.12199379
35	DYRK2	1.10419386
36	SYK	1.05032831
37	IKBKB	1.03120762
38	MUSK	1.02277900
39	WNK4	0.99321664
40	MAPK13	0.97717336
41	CSNK1G1	0.97170864
42	RIPK4	0.97000341
43	CSNK1A1L	0.96607635
44	BCR	0.96570602
45	STK38L	0.95172540
46	MAP2K7	0.92137170
47	CDK8	0.90352091
48	GRK5	0.87780036
49	CCNB1	0.87450057
50	ITK	0.86037170
51	TSSK6	0.85907276
52	VRK1	0.81707045
53	PHKG1	0.80307425
54	PHKG2	0.80307425
55	JAK3	0.77035273
56	SIK3	0.75313234
57	BUB1	0.72666990
58	STK16	0.72531614
59	BMPR2	0.71774490
60	TBK1	0.69474174
61	TESK1	0.68940612
62	LYN	0.67803078
63	BLK	0.66540375
64	WNK3	0.66372228
65	AURKA	0.65530586
66	MAP3K4	0.64784766
67	BTK	0.64174572
68	IRAK1	0.62305122
69	LIMK1	0.60208219
70	PAK3	0.58275568
71	EIF2AK1	0.55834857
72	FER	0.54022647
73	LCK	0.53658478
74	GRK7	0.51057632
75	EIF2AK2	0.50606310
76	IKBKE	0.50552644
77	ERBB3	0.50533464
78	KIT	0.49671160
79	MARK1	0.48525951
80	INSRR	0.47771611
81	DAPK2	0.47177493
82	RPS6KA5	0.46174653
83	PIM2	0.45216540
84	PLK3	0.45109208
85	IGF1R	0.44265146
86	PRKCE	0.43244627
87	TNK2	0.41123082
88	MAPK4	0.40135434
89	RPS6KA4	0.39381767
90	MAP2K6	0.39301842
91	PIM1	0.39167294
92	CSNK1A1	0.38519451
93	ILK	0.37920500
94	NEK1	0.37008020
95	MAP3K5	0.35917332
96	PRKCQ	0.35414598
97	PRKCG	0.34757577
98	PRKACA	0.34521180
99	MAP2K2	0.34021398
100	MATK	0.32146591

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	3.32745931
2	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.63105598
3	Phototransduction_Homo sapiens_hsa04744	2.54722873
4	Graft-versus-host disease_Homo sapiens_hsa05332	2.43399407
5	Primary immunodeficiency_Homo sapiens_hsa05340	2.28129287
6	Sulfur metabolism_Homo sapiens_hsa00920	2.20007148
7	Asthma_Homo sapiens_hsa05310	2.16364225
8	Allograft rejection_Homo sapiens_hsa05330	2.10947712
9	Oxidative phosphorylation_Homo sapiens_hsa00190	2.07152194
10	Selenocompound metabolism_Homo sapiens_hsa00450	2.04313505
11	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.99688193
12	Parkinsons disease_Homo sapiens_hsa05012	1.80062310
13	Nitrogen metabolism_Homo sapiens_hsa00910	1.67330658
14	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.64866567
15	Renin-angiotensin system_Homo sapiens_hsa04614	1.61557950
16	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.58205824
17	Nicotine addiction_Homo sapiens_hsa05033	1.56250765
18	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.55986774
19	Type I diabetes mellitus_Homo sapiens_hsa04940	1.53909355
20	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.49831685
21	Antigen processing and presentation_Homo sapiens_hsa04612	1.47383551
22	RNA polymerase_Homo sapiens_hsa03020	1.46323049
23	Linoleic acid metabolism_Homo sapiens_hsa00591	1.44426167
24	Caffeine metabolism_Homo sapiens_hsa00232	1.41785316
25	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.37060435
26	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.36401772
27	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.30813059
28	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.30665369
29	Protein export_Homo sapiens_hsa03060	1.30445671
30	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.27155369
31	Retinol metabolism_Homo sapiens_hsa00830	1.25712053
32	Butanoate metabolism_Homo sapiens_hsa00650	1.21020511
33	Fatty acid elongation_Homo sapiens_hsa00062	1.16434107
34	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.15166962
35	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.12820970
36	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.12070013
37	Taste transduction_Homo sapiens_hsa04742	1.11849473
38	Rheumatoid arthritis_Homo sapiens_hsa05323	1.11091252
39	Chemical carcinogenesis_Homo sapiens_hsa05204	1.09068073
40	One carbon pool by folate_Homo sapiens_hsa00670	1.07237695
41	Homologous recombination_Homo sapiens_hsa03440	1.06303184
42	Viral myocarditis_Homo sapiens_hsa05416	1.05958172
43	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.04678679
44	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.04599640
45	RNA degradation_Homo sapiens_hsa03018	1.03626550
46	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.03276207
47	Basal transcription factors_Homo sapiens_hsa03022	1.01962197
48	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.01711620
49	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.01005985
50	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.00126332
51	Morphine addiction_Homo sapiens_hsa05032	0.97908762
52	Alzheimers disease_Homo sapiens_hsa05010	0.95382702
53	Propanoate metabolism_Homo sapiens_hsa00640	0.94870439
54	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.94286900
55	Sulfur relay system_Homo sapiens_hsa04122	0.93302467
56	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.91274178
57	Peroxisome_Homo sapiens_hsa04146	0.91094777
58	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.90837895
59	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.87940277
60	Huntingtons disease_Homo sapiens_hsa05016	0.87221815
61	Cardiac muscle contraction_Homo sapiens_hsa04260	0.86879029
62	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.86387431
63	Collecting duct acid secretion_Homo sapiens_hsa04966	0.84615034
64	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.83741144
65	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.77735144
66	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.77041025
67	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.76043899
68	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.74778743
69	Ether lipid metabolism_Homo sapiens_hsa00565	0.74039622
70	Regulation of autophagy_Homo sapiens_hsa04140	0.74025174
71	GABAergic synapse_Homo sapiens_hsa04727	0.72177771
72	Base excision repair_Homo sapiens_hsa03410	0.70960593
73	Pyrimidine metabolism_Homo sapiens_hsa00240	0.70657816
74	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.67303649
75	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.66879568
76	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.64839011
77	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.64783166
78	Purine metabolism_Homo sapiens_hsa00230	0.64782979
79	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.63354071
80	ABC transporters_Homo sapiens_hsa02010	0.62796581
81	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.62495109
82	Fatty acid metabolism_Homo sapiens_hsa01212	0.62089866
83	Olfactory transduction_Homo sapiens_hsa04740	0.62085185
84	Tryptophan metabolism_Homo sapiens_hsa00380	0.60682689
85	Non-homologous end-joining_Homo sapiens_hsa03450	0.57996785
86	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.57718425
87	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.57267639
88	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.55615793
89	Salivary secretion_Homo sapiens_hsa04970	0.54598809
90	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.51160636
91	Spliceosome_Homo sapiens_hsa03040	0.50799337
92	Metabolic pathways_Homo sapiens_hsa01100	0.49055891
93	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.48882872
94	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.48161441
95	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.47520105
96	Glycerolipid metabolism_Homo sapiens_hsa00561	0.45544265
97	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.38601914
98	Circadian entrainment_Homo sapiens_hsa04713	0.38234783
99	Fanconi anemia pathway_Homo sapiens_hsa03460	0.38082178
100	Steroid biosynthesis_Homo sapiens_hsa00100	0.37815490

ACTG1P23

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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