ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	7.62380254
2	cytidine deamination (GO:0009972)	5.93788518
3	cytidine metabolic process (GO:0046087)	5.93788518
4	cytidine catabolic process (GO:0006216)	5.93788518
5	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	5.82295539
6	pyrimidine ribonucleoside catabolic process (GO:0046133)	5.13144090
7	regulation of regulatory T cell differentiation (GO:0045589)	4.71732967
8	cellular response to interleukin-15 (GO:0071350)	4.71383605
9	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	4.61269997
10	regulation of isotype switching to IgG isotypes (GO:0048302)	4.60747427
11	protein deneddylation (GO:0000338)	4.30238468
12	protein neddylation (GO:0045116)	4.30124571
13	regulation of immunoglobulin secretion (GO:0051023)	4.29756658
14	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	3.96452022
15	positive regulation of defense response to virus by host (GO:0002230)	3.84667881
16	response to interleukin-15 (GO:0070672)	3.84584641
17	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.79256791
18	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.79256791
19	proteasome assembly (GO:0043248)	3.69840600
20	positive regulation of isotype switching (GO:0045830)	3.67997780
21	preassembly of GPI anchor in ER membrane (GO:0016254)	3.64357905
22	sequestering of actin monomers (GO:0042989)	3.64036242
23	positive regulation of DNA recombination (GO:0045911)	3.50250568
24	platelet dense granule organization (GO:0060155)	3.49715373
25	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.45975622
26	water-soluble vitamin biosynthetic process (GO:0042364)	3.43464785
27	negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)	3.43119193
28	negative regulation of T-helper cell differentiation (GO:0045623)	3.43119193
29	cullin deneddylation (GO:0010388)	3.38251220
30	negative regulation of telomere maintenance (GO:0032205)	3.33978054
31	rRNA catabolic process (GO:0016075)	3.33583527
32	regulation of defense response to virus by host (GO:0050691)	3.28336437
33	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.28313628
34	NADH dehydrogenase complex assembly (GO:0010257)	3.28313628
35	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.28313628
36	chaperone-mediated protein transport (GO:0072321)	3.22972489
37	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	3.21530786
38	Arp2/3 complex-mediated actin nucleation (GO:0034314)	3.17700143
39	protein complex biogenesis (GO:0070271)	3.17268600
40	negative T cell selection (GO:0043383)	3.15507956
41	L-methionine salvage (GO:0071267)	3.15211876
42	L-methionine biosynthetic process (GO:0071265)	3.15211876
43	amino acid salvage (GO:0043102)	3.15211876
44	regulation of memory T cell differentiation (GO:0043380)	3.13872797
45	regulation of cellular amino acid metabolic process (GO:0006521)	3.08610493
46	regulation of chronic inflammatory response (GO:0002676)	3.03584286
47	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.93749676
48	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.92346845
49	mitochondrial respiratory chain complex assembly (GO:0033108)	2.89322440
50	negative regulation of cell killing (GO:0031342)	2.86488692
51	negative regulation of leukocyte mediated cytotoxicity (GO:0001911)	2.86488692
52	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.86310188
53	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	2.84232057
54	positive regulation of immunoglobulin production (GO:0002639)	2.82383106
55	positive regulation of T cell differentiation in thymus (GO:0033089)	2.82228926
56	respiratory chain complex IV assembly (GO:0008535)	2.79920624
57	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.79712272
58	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.78219707
59	positive regulation of natural killer cell mediated immunity (GO:0002717)	2.77767160
60	actin nucleation (GO:0045010)	2.76548959
61	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.76518636
62	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.76518636
63	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.76518636
64	mannosylation (GO:0097502)	2.76493852
65	protein-cofactor linkage (GO:0018065)	2.75082167
66	negative regulation of alpha-beta T cell differentiation (GO:0046639)	2.74208637
67	S-adenosylmethionine metabolic process (GO:0046500)	2.73508824
68	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.73437315
69	ATP synthesis coupled proton transport (GO:0015986)	2.73437315
70	positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)	2.72035487
71	C-terminal protein lipidation (GO:0006501)	2.70222344
72	positive regulation of alpha-beta T cell proliferation (GO:0046641)	2.69942097
73	GPI anchor metabolic process (GO:0006505)	2.69684610
74	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.69320293
75	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.69320293
76	regulation of leukocyte mediated cytotoxicity (GO:0001910)	2.68999900
77	negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)	2.68901768
78	negative thymic T cell selection (GO:0045060)	2.66572923
79	GPI anchor biosynthetic process (GO:0006506)	2.66535994
80	positive regulation of B cell mediated immunity (GO:0002714)	2.64215289
81	positive regulation of immunoglobulin mediated immune response (GO:0002891)	2.64215289
82	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.63095896
83	regulation of T cell mediated cytotoxicity (GO:0001914)	2.62790095
84	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.61872035
85	C-terminal protein amino acid modification (GO:0018410)	2.59130444
86	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.58553334
87	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.58553334
88	pyrimidine nucleoside catabolic process (GO:0046135)	2.58464383
89	negative regulation of T cell apoptotic process (GO:0070233)	2.58438104
90	positive regulation of leukocyte mediated cytotoxicity (GO:0001912)	2.58344914
91	DNA catabolic process, exonucleolytic (GO:0000738)	2.57405067
92	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.57378696
93	negative regulation of ligase activity (GO:0051352)	2.57242673
94	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.57242673
95	base-excision repair, AP site formation (GO:0006285)	2.55286197
96	viral mRNA export from host cell nucleus (GO:0046784)	2.54752067
97	DNA dealkylation (GO:0035510)	2.54020113
98	negative regulation of lymphocyte apoptotic process (GO:0070229)	2.53689216
99	response to misfolded protein (GO:0051788)	2.53675882
100	isotype switching (GO:0045190)	2.53520142

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	4.43540973
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.40298177
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.16998374
4	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.51155943
5	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.46735554
6	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.39023806
7	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.14023971
8	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.99357424
9	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.92298416
10	VDR_23849224_ChIP-Seq_CD4+_Human	2.91025887
11	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.76207247
12	ZNF274_21170338_ChIP-Seq_K562_Hela	2.67285968
13	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.57783228
14	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.47313674
15	FOXP3_21729870_ChIP-Seq_TREG_Human	2.45432056
16	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.36433196
17	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.35774960
18	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	2.30246958
19	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	2.30002926
20	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	2.28989251
21	ELK1_19687146_ChIP-ChIP_HELA_Human	2.24962232
22	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.22158296
23	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.15495398
24	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	2.10041830
25	VDR_22108803_ChIP-Seq_LS180_Human	1.99200006
26	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.90409347
27	MYC_18940864_ChIP-ChIP_HL60_Human	1.87008534
28	GATA3_26560356_Chip-Seq_TH2_Human	1.79863442
29	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.78013577
30	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.68690092
31	GABP_19822575_ChIP-Seq_HepG2_Human	1.68280780
32	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.66655878
33	IGF1R_20145208_ChIP-Seq_DFB_Human	1.66518072
34	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.58300690
35	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.57751849
36	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.56011903
37	MYB_26560356_Chip-Seq_TH2_Human	1.53383880
38	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.53292884
39	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.50129528
40	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.50023847
41	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.48858510
42	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.48075639
43	CIITA_25753668_ChIP-Seq_RAJI_Human	1.47121276
44	IRF1_19129219_ChIP-ChIP_H3396_Human	1.41195099
45	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.40295489
46	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.39098066
47	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.38483293
48	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.37918824
49	TP53_22573176_ChIP-Seq_HFKS_Human	1.36447386
50	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.35404901
51	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.35226961
52	DCP1A_22483619_ChIP-Seq_HELA_Human	1.33565161
53	RUNX_20019798_ChIP-Seq_JUKART_Human	1.31385120
54	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.29567077
55	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.27334564
56	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.27125553
57	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.25365995
58	AR_20517297_ChIP-Seq_VCAP_Human	1.22374604
59	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.21402811
60	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.21209616
61	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.20503701
62	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.16140283
63	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.15087164
64	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.14368363
65	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.14288118
66	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.13978317
67	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.13798398
68	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.13798398
69	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.13692693
70	GATA3_27048872_Chip-Seq_THYMUS_Human	1.13668506
71	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.13007975
72	NANOG_20526341_ChIP-Seq_ESCs_Human	1.12005377
73	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.11408232
74	BCL6_27268052_Chip-Seq_Bcells_Human	1.10279440
75	TAF15_26573619_Chip-Seq_HEK293_Human	1.09633082
76	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.09627497
77	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.09505473
78	EWS_26573619_Chip-Seq_HEK293_Human	1.06547195
79	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.06314325
80	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.06180586
81	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.03988449
82	ERA_21632823_ChIP-Seq_H3396_Human	1.03297927
83	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.03213466
84	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.03043085
85	GATA3_26560356_Chip-Seq_TH1_Human	1.01442770
86	GATA2_20887958_ChIP-Seq_HPC-7_Mouse	0.99254084
87	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.99060895
88	P300_27268052_Chip-Seq_Bcells_Human	0.96974885
89	TAF2_19829295_ChIP-Seq_ESCs_Human	0.95212080
90	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	0.92462665
91	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.92035809
92	ERG_20517297_ChIP-Seq_VCAP_Human	0.90987111
93	MYC_19030024_ChIP-ChIP_MESCs_Mouse	0.89803491
94	MYC_19829295_ChIP-Seq_ESCs_Human	0.89681947
95	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.88545819
96	OCT4_20526341_ChIP-Seq_ESCs_Human	0.87190373
97	E2F1_20622854_ChIP-Seq_HELA_Human	0.86942209
98	HOXB7_26014856_ChIP-Seq_BT474_Human	0.84674989
99	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.84478264
100	SPI1_23547873_ChIP-Seq_NB4_Human	0.83580493

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005671_abnormal_response_to	4.71220364
2	MP0004145_abnormal_muscle_electrophysio	3.42687859
3	MP0002822_catalepsy	3.26209341
4	MP0001835_abnormal_antigen_presentation	3.06265635
5	MP0002102_abnormal_ear_morphology	2.83721194
6	MP0008875_abnormal_xenobiotic_pharmacok	2.72857058
7	MP0003011_delayed_dark_adaptation	2.62138604
8	MP0005645_abnormal_hypothalamus_physiol	2.60123621
9	MP0001853_heart_inflammation	2.50082162
10	MP0002148_abnormal_hypersensitivity_rea	2.41411134
11	MP0000465_gastrointestinal_hemorrhage	2.38594633
12	MP0003786_premature_aging	2.18054426
13	MP0001529_abnormal_vocalization	2.12108338
14	MP0004147_increased_porphyrin_level	2.02999678
15	MP0003693_abnormal_embryo_hatching	1.98796024
16	MP0008872_abnormal_physiological_respon	1.98738795
17	MP0003724_increased_susceptibility_to	1.94000555
18	MP0003763_abnormal_thymus_physiology	1.89852355
19	MP0003806_abnormal_nucleotide_metabolis	1.79071559
20	MP0006082_CNS_inflammation	1.77179787
21	MP0005000_abnormal_immune_tolerance	1.70909573
22	MP0003195_calcinosis	1.68949507
23	MP0003866_abnormal_defecation	1.65759664
24	MP0005085_abnormal_gallbladder_physiolo	1.63227724
25	MP0005167_abnormal_blood-brain_barrier	1.62264575
26	MP0001800_abnormal_humoral_immune	1.62221468
27	MP0006072_abnormal_retinal_apoptosis	1.60673432
28	MP0002277_abnormal_respiratory_mucosa	1.57841196
29	MP0002723_abnormal_immune_serum	1.56387535
30	MP0002166_altered_tumor_susceptibility	1.55315789
31	MP0008775_abnormal_heart_ventricle	1.52532316
32	MP0002420_abnormal_adaptive_immunity	1.52083346
33	MP0008789_abnormal_olfactory_epithelium	1.51291693
34	MP0001819_abnormal_immune_cell	1.50689499
35	MP0009785_altered_susceptibility_to	1.49891376
36	MP0005253_abnormal_eye_physiology	1.45335354
37	MP0005551_abnormal_eye_electrophysiolog	1.41382894
38	MP0006036_abnormal_mitochondrial_physio	1.37664316
39	MP0002837_dystrophic_cardiac_calcinosis	1.36647828
40	MP0008058_abnormal_DNA_repair	1.36614160
41	MP0002452_abnormal_antigen_presenting	1.36187342
42	MP0008877_abnormal_DNA_methylation	1.34302381
43	MP0000372_irregular_coat_pigmentation	1.33365063
44	MP0000685_abnormal_immune_system	1.29139444
45	MP0005025_abnormal_response_to	1.27284131
46	MP0001873_stomach_inflammation	1.26695884
47	MP0002933_joint_inflammation	1.25340727
48	MP0001905_abnormal_dopamine_level	1.25179154
49	MP0001986_abnormal_taste_sensitivity	1.23856470
50	MP0005387_immune_system_phenotype	1.22429506
51	MP0001790_abnormal_immune_system	1.22429506
52	MP0002006_tumorigenesis	1.21436972
53	MP0002398_abnormal_bone_marrow	1.18146429
54	MP0005084_abnormal_gallbladder_morpholo	1.17373571
55	MP0003646_muscle_fatigue	1.16470246
56	MP0000716_abnormal_immune_system	1.16204438
57	MP0000689_abnormal_spleen_morphology	1.15261791
58	MP0001348_abnormal_lacrimal_gland	1.11847155
59	MP0000013_abnormal_adipose_tissue	1.09104258
60	MP0004142_abnormal_muscle_tone	1.08324992
61	MP0010368_abnormal_lymphatic_system	1.06532142
62	MP0002736_abnormal_nociception_after	1.05127051
63	MP0005499_abnormal_olfactory_system	1.04294069
64	MP0005394_taste/olfaction_phenotype	1.04294069
65	MP0001845_abnormal_inflammatory_respons	1.03313886
66	MP0010155_abnormal_intestine_physiology	1.00218923
67	MP0002429_abnormal_blood_cell	0.98224285
68	MP0009764_decreased_sensitivity_to	0.97653817
69	MP0002722_abnormal_immune_system	0.91478085
70	MP0008995_early_reproductive_senescence	0.91307759
71	MP0001727_abnormal_embryo_implantation	0.90623580
72	MP0000015_abnormal_ear_pigmentation	0.89285231
73	MP0003111_abnormal_nucleus_morphology	0.89220489
74	MP0003137_abnormal_impulse_conducting	0.88425060
75	MP0004215_abnormal_myocardial_fiber	0.87237258
76	MP0001919_abnormal_reproductive_system	0.86226769
77	MP0005410_abnormal_fertilization	0.84980986
78	MP0010094_abnormal_chromosome_stability	0.83784626
79	MP0006276_abnormal_autonomic_nervous	0.81338975
80	MP0003186_abnormal_redox_activity	0.81059601
81	MP0005075_abnormal_melanosome_morpholog	0.80555156
82	MP0006035_abnormal_mitochondrial_morpho	0.80416712
83	MP0000703_abnormal_thymus_morphology	0.79797411
84	MP0001765_abnormal_ion_homeostasis	0.78109929
85	MP0002095_abnormal_skin_pigmentation	0.77562064
86	MP0003045_fibrosis	0.77110959
87	MP0002876_abnormal_thyroid_physiology	0.77020675
88	MP0005165_increased_susceptibility_to	0.76211575
89	MP0002138_abnormal_hepatobiliary_system	0.75766533
90	MP0010329_abnormal_lipoprotein_level	0.75492979
91	MP0002019_abnormal_tumor_incidence	0.72585571
92	MP0001968_abnormal_touch/_nociception	0.72425315
93	MP0005464_abnormal_platelet_physiology	0.71364665
94	MP0001243_abnormal_dermal_layer	0.70120615
95	MP0001984_abnormal_olfaction	0.68778557
96	MP0009333_abnormal_splenocyte_physiolog	0.68484908
97	MP0003718_maternal_effect	0.65955240
98	MP0005636_abnormal_mineral_homeostasis	0.65681935
99	MP0005646_abnormal_pituitary_gland	0.65008410
100	MP0004957_abnormal_blastocyst_morpholog	0.63720155

Predicted human phenotypes

Rank	Gene Set	Z-score
1	IgG deficiency (HP:0004315)	4.83004044
2	Elevated erythrocyte sedimentation rate (HP:0003565)	4.15630838
3	Severe combined immunodeficiency (HP:0004430)	4.04823390
4	Aplastic anemia (HP:0001915)	3.81775263
5	Increased hepatocellular lipid droplets (HP:0006565)	3.53169311
6	Lipid accumulation in hepatocytes (HP:0006561)	3.50333582
7	Renal cortical cysts (HP:0000803)	3.49743263
8	T lymphocytopenia (HP:0005403)	3.36843576
9	Abnormality of T cell number (HP:0011839)	3.34532062
10	3-Methylglutaconic aciduria (HP:0003535)	3.24152298
11	Methylmalonic acidemia (HP:0002912)	3.15788297
12	Thyroiditis (HP:0100646)	3.14725110
13	Combined immunodeficiency (HP:0005387)	3.12452201
14	Stomatitis (HP:0010280)	3.08356162
15	Abnormality of eosinophils (HP:0001879)	3.03033219
16	Increased CSF lactate (HP:0002490)	3.02755562
17	Mitochondrial inheritance (HP:0001427)	3.02077232
18	Progressive microcephaly (HP:0000253)	2.96433575
19	Renal Fanconi syndrome (HP:0001994)	2.96185836
20	Increased intramyocellular lipid droplets (HP:0012240)	2.95194559
21	Hepatocellular necrosis (HP:0001404)	2.92279256
22	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.86995580
23	Abnormality of alanine metabolism (HP:0010916)	2.86995580
24	Hyperalaninemia (HP:0003348)	2.86995580
25	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.85869484
26	Abolished electroretinogram (ERG) (HP:0000550)	2.83842635
27	Increased serum lactate (HP:0002151)	2.81318694
28	Abnormality of T cells (HP:0002843)	2.77536466
29	Methylmalonic aciduria (HP:0012120)	2.76566428
30	Increased IgM level (HP:0003496)	2.75341491
31	Hepatic necrosis (HP:0002605)	2.74642126
32	Increased muscle lipid content (HP:0009058)	2.70971230
33	Acute necrotizing encephalopathy (HP:0006965)	2.65715977
34	Type 2 muscle fiber atrophy (HP:0003554)	2.59556902
35	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.58964984
36	Abnormality of B cell number (HP:0010975)	2.58741572
37	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.55923807
38	Abnormal protein glycosylation (HP:0012346)	2.49923126
39	Abnormal glycosylation (HP:0012345)	2.49923126
40	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.49923126
41	Abnormal protein N-linked glycosylation (HP:0012347)	2.49923126
42	Attenuation of retinal blood vessels (HP:0007843)	2.49891940
43	Abnormal delayed hypersensitivity skin test (HP:0002963)	2.48349157
44	Decreased central vision (HP:0007663)	2.45074408
45	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.43897997
46	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.43897997
47	Lactic acidosis (HP:0003128)	2.42477159
48	Abnormal mitochondria in muscle tissue (HP:0008316)	2.42149746
49	Muscle fiber atrophy (HP:0100295)	2.42006181
50	Panhypogammaglobulinemia (HP:0003139)	2.35698611
51	Asplenia (HP:0001746)	2.35346186
52	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.34167653
53	Type I transferrin isoform profile (HP:0003642)	2.33792926
54	Exertional dyspnea (HP:0002875)	2.33649699
55	Cutaneous melanoma (HP:0012056)	2.33094018
56	Acute encephalopathy (HP:0006846)	2.30957611
57	Abnormality of T cell physiology (HP:0011840)	2.29157540
58	Degeneration of anterior horn cells (HP:0002398)	2.28912234
59	Abnormality of the anterior horn cell (HP:0006802)	2.28912234
60	Congenital stationary night blindness (HP:0007642)	2.27900327
61	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.27512482
62	Dicarboxylic aciduria (HP:0003215)	2.27512482
63	Reduced antithrombin III activity (HP:0001976)	2.21069679
64	Eosinophilia (HP:0001880)	2.20070248
65	Hypoproteinemia (HP:0003075)	2.17901142
66	Abnormality of the renal cortex (HP:0011035)	2.16694570
67	Pancreatic cysts (HP:0001737)	2.15622291
68	B lymphocytopenia (HP:0010976)	2.13130855
69	Tongue fasciculations (HP:0001308)	2.10134418
70	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.09618151
71	Granulocytopenia (HP:0001913)	2.08305019
72	Short tibia (HP:0005736)	2.06111709
73	Cerebral edema (HP:0002181)	2.05834571
74	Progressive macrocephaly (HP:0004481)	2.05715867
75	Anhidrosis (HP:0000970)	2.04183028
76	Acute hepatic failure (HP:0006554)	2.02414976
77	Abnormality of dental color (HP:0011073)	1.99664681
78	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.99659618
79	CNS demyelination (HP:0007305)	1.96291202
80	Abnormality of the prostate (HP:0008775)	1.95982246
81	Oral leukoplakia (HP:0002745)	1.95975133
82	Myositis (HP:0100614)	1.95865460
83	Stomach cancer (HP:0012126)	1.94558589
84	Pancytopenia (HP:0001876)	1.92015259
85	Pustule (HP:0200039)	1.90313575
86	Optic disc pallor (HP:0000543)	1.89435836
87	Abnormality of midbrain morphology (HP:0002418)	1.88240525
88	Molar tooth sign on MRI (HP:0002419)	1.88240525
89	Nephronophthisis (HP:0000090)	1.88134679
90	Neutropenia (HP:0001875)	1.86546971
91	Abnormality of vitamin B metabolism (HP:0004340)	1.84225261
92	Pancreatic fibrosis (HP:0100732)	1.83626929
93	Pulmonary fibrosis (HP:0002206)	1.83309068
94	IgM deficiency (HP:0002850)	1.83150196
95	Prostate neoplasm (HP:0100787)	1.83003391
96	True hermaphroditism (HP:0010459)	1.82214016
97	Lethargy (HP:0001254)	1.82142552
98	Pendular nystagmus (HP:0012043)	1.78586194
99	Exercise intolerance (HP:0003546)	1.77983390
100	Hyperglycinuria (HP:0003108)	1.77823725

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TESK2	4.73039647
2	MAP4K2	4.09041117
3	TXK	3.68266089
4	TLK1	3.54815626
5	ZAK	3.42508041
6	TIE1	3.24181028
7	BCKDK	3.17639273
8	MUSK	3.09777138
9	VRK2	2.99512618
10	MST4	2.57816618
11	KDR	2.53813393
12	NUAK1	2.40325215
13	GRK1	2.16591272
14	BUB1	2.06387333
15	VRK1	1.80228186
16	TAOK3	1.74317113
17	BMPR1B	1.74201787
18	GRK6	1.44722851
19	ADRBK2	1.43049971
20	WNK3	1.40161839
21	TBK1	1.35595991
22	CSNK1G3	1.23819273
23	LIMK1	1.18488358
24	SRPK1	1.16050386
25	MYLK	1.15827082
26	MAP3K12	1.13871503
27	STK16	1.13024963
28	TESK1	1.12249298
29	CSNK1A1L	1.11504163
30	NEK1	1.08033245
31	ITK	1.05578348
32	PINK1	1.05327780
33	TRIM28	1.00993674
34	MAP4K1	0.99089330
35	DAPK1	0.98185040
36	CSNK1G2	0.97436095
37	TEC	0.96053085
38	IKBKB	0.92636221
39	MATK	0.90559922
40	FES	0.90206736
41	KIT	0.89817122
42	SYK	0.87324944
43	CSNK1G1	0.86998206
44	PBK	0.84995218
45	JAK1	0.84120684
46	MAPK13	0.81853878
47	MAPKAPK3	0.81193829
48	EPHA3	0.75560188
49	EIF2AK1	0.72400908
50	WNK4	0.71888846
51	BLK	0.71275747
52	EIF2AK3	0.70870601
53	BCR	0.70757037
54	ATR	0.64855235
55	ACVR1B	0.64624619
56	GRK5	0.61461526
57	PLK2	0.59964576
58	MAP2K2	0.59861724
59	LCK	0.56480848
60	IKBKE	0.56224833
61	DYRK2	0.54305443
62	RPS6KA5	0.53922495
63	PLK3	0.52375268
64	LYN	0.51822934
65	FRK	0.51609352
66	EIF2AK2	0.50133377
67	INSRR	0.49951337
68	PRKCQ	0.49504228
69	CCNB1	0.49399413
70	IGF1R	0.48788459
71	AURKA	0.48101209
72	GRK7	0.46495673
73	STK39	0.46225206
74	BTK	0.45371726
75	OXSR1	0.43687397
76	CSK	0.42274732
77	RPS6KA4	0.41376311
78	CDK8	0.40773866
79	PRKCE	0.39829150
80	MAP3K14	0.39810036
81	TAF1	0.38149432
82	TGFBR1	0.37372726
83	OBSCN	0.36789407
84	PDK2	0.36343206
85	STK38L	0.35656538
86	PIM1	0.35022045
87	FER	0.34868269
88	PASK	0.33751067
89	TYK2	0.32973857
90	ERBB3	0.31826541
91	LATS1	0.31801088
92	PAK3	0.31497142
93	STK10	0.30843044
94	BMPR2	0.29513840
95	ZAP70	0.29338061
96	PLK1	0.29287920
97	IRAK1	0.27907380
98	AURKB	0.27465103
99	PIK3CA	0.25833968
100	HCK	0.25737293

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	3.98298615
2	Primary immunodeficiency_Homo sapiens_hsa05340	3.87066854
3	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.70399009
4	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.62248074
5	Oxidative phosphorylation_Homo sapiens_hsa00190	2.51931573
6	Asthma_Homo sapiens_hsa05310	2.37246056
7	Allograft rejection_Homo sapiens_hsa05330	2.32764196
8	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.29206753
9	Protein export_Homo sapiens_hsa03060	2.26808270
10	Parkinsons disease_Homo sapiens_hsa05012	2.20939065
11	Sulfur metabolism_Homo sapiens_hsa00920	1.98028479
12	Non-homologous end-joining_Homo sapiens_hsa03450	1.88036770
13	Graft-versus-host disease_Homo sapiens_hsa05332	1.85908665
14	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.77161983
15	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.69375079
16	Basal transcription factors_Homo sapiens_hsa03022	1.65657229
17	RNA polymerase_Homo sapiens_hsa03020	1.59554198
18	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.58190957
19	RNA degradation_Homo sapiens_hsa03018	1.58175661
20	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.54496131
21	Base excision repair_Homo sapiens_hsa03410	1.52080654
22	Propanoate metabolism_Homo sapiens_hsa00640	1.50620801
23	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.47848875
24	Fanconi anemia pathway_Homo sapiens_hsa03460	1.44594121
25	Type I diabetes mellitus_Homo sapiens_hsa04940	1.37207205
26	Antigen processing and presentation_Homo sapiens_hsa04612	1.34648948
27	Peroxisome_Homo sapiens_hsa04146	1.34381149
28	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.26675147
29	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.25836036
30	One carbon pool by folate_Homo sapiens_hsa00670	1.24073925
31	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.24050884
32	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	1.20600636
33	Phototransduction_Homo sapiens_hsa04744	1.19861382
34	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.19588939
35	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.19580504
36	Alzheimers disease_Homo sapiens_hsa05010	1.17614670
37	Huntingtons disease_Homo sapiens_hsa05016	1.16974907
38	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.14984094
39	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.09952935
40	Fatty acid elongation_Homo sapiens_hsa00062	1.04238363
41	Rheumatoid arthritis_Homo sapiens_hsa05323	1.04128318
42	Nucleotide excision repair_Homo sapiens_hsa03420	1.03383473
43	Pyrimidine metabolism_Homo sapiens_hsa00240	1.02935540
44	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.02420448
45	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.97180474
46	Regulation of autophagy_Homo sapiens_hsa04140	0.93749962
47	RNA transport_Homo sapiens_hsa03013	0.92652429
48	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.90370441
49	Linoleic acid metabolism_Homo sapiens_hsa00591	0.89125729
50	Homologous recombination_Homo sapiens_hsa03440	0.88401992
51	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.86526673
52	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.86082931
53	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.85201889
54	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.84876708
55	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.81500077
56	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.81380632
57	Purine metabolism_Homo sapiens_hsa00230	0.80505502
58	Spliceosome_Homo sapiens_hsa03040	0.79652273
59	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.79282252
60	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.76660083
61	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.76234936
62	Butanoate metabolism_Homo sapiens_hsa00650	0.75025977
63	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.73760645
64	Retinol metabolism_Homo sapiens_hsa00830	0.72264886
65	Pyruvate metabolism_Homo sapiens_hsa00620	0.69866353
66	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.68980263
67	Viral myocarditis_Homo sapiens_hsa05416	0.68888399
68	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.68099003
69	Tryptophan metabolism_Homo sapiens_hsa00380	0.67561249
70	Mismatch repair_Homo sapiens_hsa03430	0.65423490
71	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.65160341
72	Cardiac muscle contraction_Homo sapiens_hsa04260	0.63662303
73	Metabolic pathways_Homo sapiens_hsa01100	0.63417965
74	Taste transduction_Homo sapiens_hsa04742	0.60316616
75	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.60277333
76	Chemical carcinogenesis_Homo sapiens_hsa05204	0.58880187
77	Caffeine metabolism_Homo sapiens_hsa00232	0.58388324
78	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.54616662
79	DNA replication_Homo sapiens_hsa03030	0.53471126
80	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.52568450
81	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.51779115
82	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.51246541
83	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.50962739
84	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.50294919
85	Carbon metabolism_Homo sapiens_hsa01200	0.49697131
86	Steroid biosynthesis_Homo sapiens_hsa00100	0.48433201
87	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.47385252
88	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.46724387
89	Collecting duct acid secretion_Homo sapiens_hsa04966	0.46309105
90	Glutathione metabolism_Homo sapiens_hsa00480	0.45969532
91	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.45509590
92	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.44883009
93	Ribosome_Homo sapiens_hsa03010	0.44743163
94	Selenocompound metabolism_Homo sapiens_hsa00450	0.44037332
95	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.43644296
96	Renin-angiotensin system_Homo sapiens_hsa04614	0.43617357
97	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.43020720
98	Fatty acid metabolism_Homo sapiens_hsa01212	0.41731122
99	Fatty acid degradation_Homo sapiens_hsa00071	0.39558403
100	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.38267894

ACTG1P24

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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